pinecone/core-2020-05-10-deduplication huggingface dataset:
Stratified medicine for mental disorders

AbstractThere is recognition that biomedical research into the causes of mental disorders and their treatment needs to adopt new approaches to research. Novel biomedical techniques have advanced our understanding of how the brain develops and is shaped by behaviour and environment. This has led to the advent of stratified medicine, which translates advances in basic research by targeting aetiological mechanisms underlying mental disorder. The resulting increase in diagnostic precision and targeted treatments may provide a window of opportunity to address the large public health burden, and individual suffering associated with mental disorders.While mental health and mental disorders have significant representation in the “health, demographic change and wellbeing” challenge identified in Horizon 2020, the framework programme for research and innovation of the European Commission (2014–2020), and in national funding agencies, clear advice on a potential strategy for mental health research investment is needed. The development of such a strategy is supported by the EC-funded “Roadmap for Mental Health Research” (ROAMER) which will provide recommendations for a European mental health research strategy integrating the areas of biomedicine, psychology, public health well being, research integration and structuring, and stakeholder participation. Leading experts on biomedical research on mental disorders have provided an assessment of the state of the art in core psychopathological domains, including arousal and stress regulation, affect, cognition social processes, comorbidity and pharmacotherapy. They have identified major advances and promising methods and pointed out gaps to be addressed in order to achieve the promise of a stratified medicine for mental disorders
An oncologist׳s friend: How Xenopus contributes to cancer research

AbstractOne of the most striking features of the Xenopus system is the versatility in providing a unique range of both in vitro and in vivo models that are rapid, accessible and easily manipulated. Here we present an overview of the diverse contribution that Xenopus has made to advance our understanding of tumour biology and behaviour; a contribution that goes beyond the traditional view of Xenopus as a developmental model organism. From the utility of the egg and oocyte extract system to the use of whole embryos as developmental or induced tumour models, the Xenopus system has been fundamental to investigation of cell cycle mechanisms, cell metabolism, cell signalling and cell behaviour, and has allowed an increasing appreciation of the parallels between early development and the pathogenesis of tumour progression and metastasis. Although not the prototypical oncological model system, we propose that Xenopus is an adaptable and multifunctional tool in the oncologist׳s arsenal
Paule-Mandel estimators for network meta-analysis with random inconsistency effects

Network meta-analysis is used to simultaneously compare multiple treatments in a single analysis. However, network meta-analyses may exhibit inconsistency, where direct and different forms of indirect evidence are not in agreement with each other, even after allowing for between-study heterogeneity. Models for network meta-analysis with random inconsistency effects have the dual aim of allowing for inconsistencies and estimating average treatment effects across the whole network. To date, two classical estimation methods for fitting this type of model have been developed: a method of moments that extends DerSimonian and Laird's univariate method and maximum likelihood estimation. However, the Paule and Mandel estimator is another recommended classical estimation method for univariate meta-analysis. In this paper, we extend the Paule and Mandel method so that it can be used to fit models for network meta-analysis with random inconsistency effects. We apply all three estimation methods to a variety of examples that have been used previously and we also examine a challenging new dataset that is highly heterogenous. We perform a simulation study based on this new example. We find that the proposed Paule and Mandel method performs satisfactorily and generally better than the previously proposed method of moments because it provides more accurate inferences. Furthermore, the Paule and Mandel method possesses some advantages over likelihood-based methods because it is both semiparametric and requires no convergence diagnostics. Although restricted maximum likelihood estimation remains the gold standard, the proposed methodology is a fully viable alternative to this and other estimation methods
A survey of irradiated pillars, globules, and jets in the Carina nebula

We present wide-field, deep narrowband H2, Brγ, Hα, [S ii], [O iii], and broadband I- and K-band images of the Carina star formation region. The new images provide a large-scale overview of all the H2 and Brγ emission present in over a square degree centered on this signature star-forming complex. By comparing these images with archival Hubble Space Telescope and Spitzer images we observe how intense UV radiation from O and B stars affects star formation in molecular clouds. We use the images to locate new candidate outflows and identify the principal shock waves and irradiated interfaces within dozens of distinct areas of star-forming activity. Shocked molecular gas in jets traces the parts of the flow that are most shielded from the intense UV radiation. Combining the H2 and optical images gives a more complete view of the jets, which are sometimes only visible in H2. The Carina region hosts several compact young clusters, and the gas within these clusters is affected by radiation from both the cluster stars and the massive stars nearby. The Carina Nebula is ideal for studying the physics of young H ii regions and photodissociation region (PDR), as it contains multiple examples of walls and irradiated pillars at various stages of development. Some of the pillars have detached from their host molecular clouds to form proplyds. Fluorescent H2 outlines the interfaces between the ionized and molecular gas, and after removing continuum, we detect spatial offsets between the Brγ and H2 emission along the irradiated interfaces. These spatial offsets can be used to test current models of PDRs once synthetic maps of these lines become available
A-Wardp?? :
                    Effective hierarchical clustering using the Minkowski metric and a fast k-means initialisation

This document is the Accepted Manuscript version of the following article: Renato Cordeiro de Amorin, Vladimir Makrenkov, and Boris Mirkin, 'A-Wardp??: Effective hierarchical clustering using the Minkowski metric and a fast k-means initialisation', Information Services, Vol. 370-371, November 2016, pp. 343-354. The version of record is available online at doi: https://doi.org/10.1016/j.ins.2016.07.076.In this paper we make two novel contributions to hierarchical clustering. First, we introduce an anomalous pattern initialisation method for hierarchical clustering algorithms, called A-Ward, capable of substantially reducing the time they take to converge. This method generates an initial partition with a sufficiently large number of clusters. This allows the cluster merging process to start from this partition rather than from a trivial partition composed solely of singletons. Our second contribution is an extension of the Ward and Wardp algorithms to the situation where the feature weight exponent can differ from the exponent of the Minkowski distance. This new method, called A-Wardp??, is able to generate a much wider variety of clustering solutions. We also demonstrate that its parameters can be estimated reasonably well by using a cluster validity index. We perform numerous experiments using data sets with two types of noise, insertion of noise features and blurring within-cluster values of some features. These experiments allow us to conclude: (i) our anomalous pattern initialisation method does indeed reduce the time a hierarchical clustering algorithm takes to complete, without negatively impacting its cluster recovery ability; (ii) A-Wardp?? provides better cluster recovery than both Ward and Wardp
Förster resonance energy transfer, absorption and emission spectra in multichromophoric systems. III. Exact stochastic path integral evaluation

A numerically exact path integral treatment of the absorption and emission spectra of open quantum systems is presented that requires only the straightforward solution of a stochastic differential equation. The approach converges rapidly enabling the calculation of spectra of large excitonic systems across the complete range of system parameters and for arbitrary bath spectral densities. With the numerically exact absorption and emission operators, one can also immediately compute energy transfer rates using the multi-chromophoric Förster resonant energy transfer formalism. Benchmark calculations on the emission spectra of two level systems are presented demonstrating the efficacy of the stochastic approach. This is followed by calculations of the energy transfer rates between two weakly coupled dimer systems as a function of temperature and system-bath coupling strength. It is shown that the recently developed hybrid cumulant expansion (see Paper II) is the only perturbative method capable of generating uniformly reliable energy transfer rates and emission spectra across a broad range of system parameters.National Science Foundation (U.S.) (Grant CHE-1112825)United States. Dept. of Energy. Center for Excitonics (Award DE-SC0001088
Five Blood Pressure Loci Identified by an Updated Genome-Wide Linkage Scan: Meta-Analysis of the Family Blood Pressure Program

Background A preliminary genome-wide linkage analysis of blood pressure in the Family Blood Pressure Program (FBPP) was reported previously. We harnessed the power and ethnic diversity of the final pooled FBPP dataset to identify novel loci for blood pressure thereby enhancing localization of genes containing less common variants with large effects on blood pressure levels and hypertension. Methods We performed one overall and 4 race-specific meta-analyses of genome-wide blood pressure linkage scans using data on 4,226African-American, 2,154 Asian, 4,229 Caucasian, and 2,435 Mexican- American participants (total N = 13,044). Variance components models were fit to measured (raw) blood pressure levels and two types of antihypertensive medication adjusted blood pressure phenotypes within each of 10 subgroups defined by race and network. A modified Fisher's method was used to combine the P values for each linkage marker across the 10 subgroups. Results Five quantitative trait loci (QTLs) were detected on chromosomes 6p22.3, 8q23.1, 20q13.12, 21q21.1, and 21q21.3 based on significant linkage evidence (defined by logarithm of odds (lod) score ≥3) in at least one meta-analysis and lod scores ≥1 in at least 2 subgroups defined by network and race. The chromosome 8q23.1 locus was supported by Asian-, Caucasian-, and Mexican-American-specific meta-analyses. Conclusions The new QTLs reported justify new candidate gene studies. They may help support results from genome-wide association studies (GWAS) that fall in these QTL regions but fail to achieve the genome-wide significance. American Journal of Hypertension advance online publication 9 December 2010;doi:10.1038/ajh.2010.23
Novel syntactic foams made of ceramic hollow micro-spheres and starch - theory, structure and properties

Novel syntactic foams made of starch and ceramic hollow micro-spheres were developed. Foams of four different micro-sphere size groups were manufactured with either pre- or post-mould gelatinisation process. Compressive failure behaviour and mechanical properties were evaluated. Not\ud
much difference in failure behaviour or in mechanical properties between the two processes (pre- and post-mould gel) was found. Compressive failure of all syntactic foams was of shear on plane inclined 45° to compressive loading direction. Compressive strength and modulus of syntactic foams were found to be dependant mainly on binder content but mostly independent of micro-sphere size. Some conditions of relativity arising from properties of constituents leading to the rule of mixtures relationships for compressive strength and to understanding of compressive/transitional failure behaviour were developed. The developed relationships based on the rule of mixtures were partially verified
Quasi Score is more efficient than Corrected Score in a general nonlinear measurement error model

We compare two consistent estimators of the parameter vector beta of a general exponential family measurement error model with respect to their relative efficiency. The quasi score (QS) estimator uses the distribution of the regressor, the corrected score (CS) estimator does not make use of this distribution and is therefore more robust. However, if the regressor distribution is known, QS is asymptotically more efficient than CS. In some cases it is, in fact, even strictly more efficient, in the sense that the difference of the asymptotic covariance matrices of CS and QS is positive definite.
Dimension-six matrix elements for meson mixing and lifetimes from sum
  rules

The hadronic matrix elements of dimension-six $\Delta F=0,2$ operators are
crucial inputs for the theory predictions of mixing observables and lifetime
ratios in the $B$ and $D$ system. We determine them using HQET sum rules for
three-point correlators. The results of the required three-loop computation of
the correlators and the one-loop computation of the QCD-HQET matching are given
in analytic form. For mixing matrix elements we find very good agreement with
recent lattice results and comparable theoretical uncertainties. For lifetime
matrix elements we present the first ever determination in the $D$ meson sector
and the first determination of $\Delta B=0$ matrix elements with uncertainties
under control - superseeding preliminary lattice studies stemming from 2001 and
earlier. With our state-of-the-art determination of the bag parameters we
predict: $\tau(B^+)/\tau(B_d^0) = 1.082_{-0.026}^{+0.022}$,
$\tau(B_s^0)/\tau(B_d^0) = 0.9994\pm0.0025$, $\tau(D^+)/\tau(D^0) =
2.7_{-0.8}^{+0.7}$ and the mixing-observables in the $B_s$ and $B_d$ system, in
good agreement with the most recent experimental averages.Comment: 46 pages, 9 figures, Journal version. Fixed typo in fig 7 legend,
  made explicit certain factors of N_c C_
Planck intermediate results IX. Detection of the Galactic haze with Planck

Using precise full-sky observations from Planck, and applying several methods of component separation, we identify and characterise the emission from the Galactic "haze" at microwave wavelengths. The haze is a distinct component of diffuse Galactic emission, roughly centered on the Galactic centre, and extends to | b | ~ 35-50° in Galactic latitude and | l | ~ 15-20° in longitude. By combining the Planck data with observations from the Wilkinson Microwave Anisotropy Probe, we were able to determine the spectrum of this emission to high accuracy, unhindered by the strong systematic biases present in previous analyses. The derived spectrum is consistent with power-law emission with a spectral index of -2.56 ± 0.05, thus excluding free-free emission as the source and instead favouring hard-spectrum synchrotron radiation from an electron population with a spectrum (number density per energy) dN/dE ∝ E-2.1. At Galactic latitudes | b | < 30°, the microwave haze morphology is consistent with that of the Fermi gamma-ray "haze" or "bubbles", while at b ~ -50° we have identified an edge in the microwave haze that is spatially coincident with the edge in the gamma-ray bubbles. Taken together, this indicates that we have a multi-wavelength view of a distinct component of our Galaxy. Given both the very hard spectrum and the extended nature of the emission, it is highly unlikely that the haze electrons result from supernova shocks in the Galactic disk. Instead, a new astrophysical mechanism for cosmic-ray acceleration in the inner Galaxy is implied. © 2013 ESO
Design of novel bioactive materials through organic modification of calcium silicate

Bioactive ceramics have attractive feature for bone repair such as direct bone-bonding in the body. However their clinical application is limited to low loaded portions due to their inappropriate mechanical performances such as higher brittleness and lower flexibility than natural bone. The essential condition for artificial materials to show bioactivity is formation of bone-like apatite on their surfaces in body environment. This apatite formation is triggered by silanol (Si–OH) group on the material surfaces and release of Ca2+. These findings bring us an idea that novel bioactive materials with high flexibility can be designed by organic modification of calcium silicate. We synthesized organic–inorganic hybrids from organic polymers including 2-hydroxyethylmethacrylate (HEMA), starch and alginate by modification with alkoxysilane and calcium chloride. The hybrids formed apatite on their surfaces in simulated body fluid (SBF, Kokubo solution). Such a modification was also effective for providing conventional polymethylmethacrylate (PMMA)-based bone cement with bioactivity.IX Conference and Exhibition of the European Ceramic Society: June 19-23, 2005, Portorož, Sloveni
Scientific rationale and international obligations for protection of active hydrothermal vent ecosystems from deep-sea mining

Highlights\ud
\ud
•    Active hydrothermal vent ecosystems are extremely rare.\ud
•    Vent ecosystems are recognized as vulnerable by international organizations.\ud
•    Mineral resources at active vents would not contribute significantly to the global metal supply.\ud
•    Effective networks that protect representative active vents cannot be ensured.\ud
•    A prohibition on mining active vents is consistent with obligations for conservation.\ud
\ud
Abstract\ud
\ud
There is increasing interest in mining minerals on the seabed, including seafloor massive sulfide deposits that form at hydrothermal vents. The International Seabed Authority is currently drafting a Mining Code, including environmental regulations, for polymetallic sulfides and other mineral exploitation on the seabed in the area beyond national jurisdictions. This paper summarizes 1) the ecological vulnerability of active vent ecosystems and aspects of this vulnerability that remain subject to conjecture, 2) evidence for limited mineral resource opportunity at active vents, 3) non-extractive values of active vent ecosystems, 4) precedents and international obligations for protection of hydrothermal vents, and 5) obligations of the International Seabed Authority under the UN Convention on the Law of the Sea for protection of the marine environment from the impacts of mining. Heterogeneity of active vent ecosystems makes it extremely challenging to identify “representative” systems for any regional, area-based management approach to conservation. Protection of active vent ecosystems from mining impacts (direct and indirect) would set aside only a small fraction of the international seabed and its mineral resources, would contribute to international obligations for marine conservation, would have non-extractive benefits, and would be a precautionary approach
The incidence rate of prostate cancer in Saudi Arabia: an observational descriptive epidemiological analysis of data from the Saudi Cancer Registry 2001-2008

Background This study presents descriptive epidemiological data related to prostate cancer cases diagnosed from 2001 to 2008 among Saudi men, including the frequency and percentage of cases, the crude incidence rate (CIR) and the age-standardised incidence rate (ASIR) adjusted by region and year of diagnosis. Methods This is a retrospective descriptive epidemiological analysis of all Saudi prostate cancer cases recorded in the Saudi Cancer Registry (SCR) between January 2001 and December 2008. Statistical analyses were conducted using descriptive statistics, the Poisson regression model, a simple linear regression model and analysis of variance with the Statistical Package for the Social Sciences version 20.0 (SPSS). Results A total of 1739 cases were registered in the SCR between January 2001 and December 2008. The eastern region of Saudi Arabia had the highest overall ASIR at 10.1 per 100,000 men, followed by Riyadh at 7.1 and Makkah at 5.2, while Jizan and Najran had the lowest average ASIRs at 1.4 and at 2.0, respectively. The Poisson regression model for the region of Jizan shows that the incidence rate ratio (IRR) was significantly higher (p < 0.001); for the regions of Riyadh at 3.43 times (95 CI, 3.13-3.73), followed by Makkah at 2.56 (95 CI, 2.38-2.74) and the eastern province at 1.93 (95 CI, 1.64-2.23). The annual prediction of the CIR of prostate cancer in Saudi Arabia could be defined by the equation 1.53 + (0.094 Ã� Years), and the prediction of the ASIR could be defined by the equation 2.98 + (0.182 Ã� Years). Conclusion There was a steady increase in the CIRs and ASIRs for prostate cancer between 2001 and 2008. The eastern region, Riyadh and Makkah had the highest overall ASIR in Saudi Arabia. Further effective screening programmes and active treatment measures are needed to control prostate cancer disease among Saudi men. Â© 2013 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd. All rights reserved
Ecological distribution conflicts as forces for sustainability : an overview and conceptual framework

Unidad de excelencia María de Maeztu MdM-2015-0552Centre: ICTA Digital object identifier for the 'European Research Council' (http://dx.doi.org/10.13039/501100000781) Digital object identifier for 'Horizon 2020' (http://dx.doi.org/10.13039/501100007601).Can ecological distribution conflicts turn into forces for sustainability? This overview paper addresses in a systematic conceptual manner the question of why, through whom, how, and when conflicts over the use of the environment may take an active role in shaping transitions toward sustainability. It presents a conceptual framework that schematically maps out the linkages between (a) patterns of (unsustainable) social metabolism, (b) the emergence of ecological distribution conflicts, (c) the rise of environmental justice movements, and (d) their potential contributions for sustainability transitions. The ways how these four processes can influence each other are multi-faceted and often not a foretold story. Yet, ecological distribution conflicts can have an important role for sustainability, because they relentlessly bring to light conflicting values over the environment as well as unsustainable resource uses affecting people and the planet. Environmental justice movements, born out of such conflicts, become key actors in politicizing such unsustainable resource uses, but moreover, they take sometimes also radical actions to stop them. By drawing on creative forms of mobilizations and diverse repertoires of action to effectively reduce unsustainabilities, they can turn from ‘victims’ of environmental injustices into ‘warriors’ for sustainability. But when will improvements in sustainability be lasting? By looking at the overall dynamics between the four processes, we aim to foster a more systematic understanding of the dynamics and roles of ecological distribution conflicts within sustainability processes