pinecone/core-2020-05-10-deduplication huggingface dataset:
Identifying jumps in financial assets: A comparison between nonparametric jump tests

We perform a comprehensive Monte Carlo comparison between nine alternative procedures available in the literature to detect jumps in financial assets using high-frequency data. We evaluate size and power properties of the procedures under alternative sampling frequencies, persistence in volatility, jump size and intensity, and degree of contamination with microstructure noise. The overall best performance is shown by the Andersen, Bollerslev, and Dobrev (2007) and Lee and Mykland (2008) intraday procedures (ABD-LM), provided the price process is not very volatile. We propose two extensions to the existing battery of tests. The first regards the finite sample improvements based on simulated critical values for the ABD-LM procedure. The second regards a procedure that combines frequencies and tests able to reduce the number of spurious jumps. Finally, we report an empirical analysis using real high frequency data on five stocks listed in the New York Stock Exchange
Snake states and their symmetries in graphene

Snake states are open trajectories for charged particles propagating in two
dimensions under the influence of a spatially varying perpendicular magnetic
field. In the quantum limit they are protected edge modes that separate
topologically inequivalent ground states and can also occur when the particle
density rather than the field is made nonuniform. We examine the correspondence
of snake trajectories in single-layer graphene in the quantum limit for two
families of domain walls: (a) a uniform doped carrier density in an
antisymmetric field profile and (b) antisymmetric carrier distribution in a
uniform field. These families support different internal symmetries but the
same pattern of boundary and interface currents. We demonstrate that these
physically different situations are gauge equivalent when rewritten in a Nambu
doubled formulation of the two limiting problems. Using gauge transformations
in particle-hole space to connect these problems, we map the protected
interfacial modes to the Bogoliubov quasiparticles of an interfacial
one-dimensional p-wave paired state. A variational model is introduced to
interpret the interfacial solutions of both domain wall problems
A wavelet analysis of CMB time ordered data: application to Archeops

submitted to A & A Figures in jpg format For a full postcript vesion of the paper, please contact the authorsWe present an alternative analysis of CMB time ordered data (TOD) using a wavelet-based representation of the data time-frequency plane. We demonstrate that the wavelet transform decorrelates $1/f$-type Gaussian stationary noise and permits a simple and functional description of locally stationary processes. In particular, this makes possible the generalization of the classical algorithms of map making and CMB power spectrum estimation to the case of locally stationary 1/f type noise. As an example, we present a wavelet based algorithm for the destriping of CMB-like maps. In addition, we describe a wavelet-based analysis of the Archeops data including time-frequency visualization, wavelet destriping and filtering of the TOD. These filtered data was used to produce polarized maps of Galactic dust diffuse emission. Finally, we describe the modeling of the non-stationarity on the Archeops noise for the estimation of the CMB power spectrum
Role of proton irradiation and relative air humidity on iron corrosion

ACE, Journal of Nuclear MaterialsInternational audienceThis paper presents a study of the effects of proton irradiation on iron corrosion. Since it is known that in humid atmospheres, iron corrosion is enhanced by the double influence of air and humidity, we studied the iron corrosion under irradiation with a 45% relative humidity. Three proton beam intensities (5, 10 and 20 nA) were used. To characterise the corrosion layer, we used ion beam methods (Rutherford Backscattering Spectrometry (RBS), Elastic Recoil Detection Analysis (ERDA)) and X-ray Diffraction (XRD) analysis. The corrosion kinetics are plotted for each proton flux. A diffusion model of the oxidant species is proposed, taking into account the fact that the flux through the surface is dependent on the kinetic factor K. This model provides evidence for the dependence of the diffusion coefficient, D, and the kinetic factor, K, on the proton beam intensity. Comparison of the values for D with the diffusion coefficients for thermal oxygen diffusion in iron at 300 K suggests an enhancement due to irradiation of 6 orders of magnitude
Axial magnetic anomalies over slow-spreading ridge segments: insights from numerical 3-D thermal and physical modelling

International audienceThe axial magnetic anomaly amplitude along Mid-Atlantic Ridge segments is systematically twice as high at segment ends compared with segment centres. Various processes have been proposed to account for such observations, either directly or indirectly related to the thermal structure of the segments: (1) shallower Curie isotherm at segment centres, (2) higher Fe-Ti content at segment ends, (3) serpentinized peridotites at segment ends or (4) a combination of these processes. In this paper the contribution of each of these processes to the axial magnetic anomaly amplitude is quantitatively evaluated by achieving a 3-D numerical modelling of the magnetization distribution and a magnetic anomaly over a medium-sized, 50 km long segment. The magnetization distribution depends on the thermal structure and thermal evolution of the lithosphere. The thermal structure is calculated considering the presence of a permanent hot zone beneath the segment centre. The 'best-fitting' thermal structure is determined by adjusting the parameters (shape, size, depth, etc.) of this hot zone, to fit the modelled geophysical outputs (Mantle Bouguer anomaly, maximum earthquake depths and crustal thickness) to the observations. Both the thermoremanent magnetization, acquired during the thermal evolution, and the induced magnetization, which depends on the present thermal structure, are modelled. The resulting magnetic anomalies are then computed and compared with the observed ones. This modelling exercise suggests that, in the case of aligned and slightly offset segments, a combination of higher Fe-Ti content and the presence of serpentinized peridotites at segment ends will produce the observed higher axial magnetic anomaly amplitudes over the segment ends. In the case of greater offsets, the presence of serpentinized peridotites at segment ends is sufficient to account for the observations
In Antisynthetase Syndrome, ACPA Are Associated With Severe and Erosive Arthritis: An Overlapping Rheumatoid Arthritis and Antisynthetase Syndrome

International audienceAbstract: Anticitrullinated peptide/protein antibodies (ACPA), which are highly specific for rheumatoid arthritis (RA), may be found in some patients with other systemic autoimmune diseases. The clinical significance of ACPA in patients with antisynthetase syndrome (ASS), a systemic disease characterized by the association of myositis, interstitial lung disease, polyarthralgia, and/or polyarthritis, has not yet been evaluated with regard to phenotype, prognosis, and response to treatment. ACPA-positive ASS patients were first identified among a French multicenter registry of patients with ASS. Additionally, all French rheumatology and internal medicine practitioners registered on the Club Rhumatismes et Inflammation web site were asked to report their observations of ASS patients with ACPA. The 17 collected patients were retrospectively studied using a standardized questionnaire and compared with 34 unselected ACPA-negative ASS patients in a case–control study. All ACPA-positive ASS patients suffered from arthritis versus 41% in the control group (P < 0.0001). The number of swollen joints was significantly higher (7.0 ± 5.0 vs 2.9 ± 3.9, P < 0.005), with a distribution resembling that of RA. Radiographic damages were also more frequent in ACPA-positive ASS patients (87% vs 11%, P < 0.0001). Aside from a significantly higher transfer factor for carbon monoxide in ACPA–ASS patients, lung, muscle, and skin involvements had similar incidences, patterns, and severity in both groups. Although Nonbiologic treatments were similarly used in both groups, ACPA-positive patients received biologics more frequently (59% vs 12%, P < 0.0008), mostly due to refractory arthritis (n = 9). Eight patients received anti-Cluster of differentiation 20 (CD20) monoclonal antibodies (mAbs) with good efficacy and tolerance, whereas 2 of the 5 patients treated with antitumor necrosis factor drugs had worsened myositis and/or interstitial lung disease. After a >7-year mean follow-up, extra-articular outcomes and survival were not different. ACPA-positive ASS patients showed an overlapping RA–ASS syndrome, were at high risk of refractory erosive arthritis, and might experience ASS flare when treated with antitumor necrosis factor drugs. In contrast, other biologics such as anti-CD20 mAb were effective in this context, without worsening systemic involvements
New Late Neolithic (c. 7000–5000 BC) archeointensity data from Syria. Reconstructing 9000years of archeomagnetic field intensity variations in the Middle East

International audienceWe present new archeomagnetic intensity data from two Late Neolithic archeological sites (Tell Halula and Tell Masaïkh) in Syria. These data, from 24 groups of potsherds encompassing 15 different time levels, are obtained using the Triaxe experimental protocol, which takes into account both the thermoremanent magnetization anisotropy and cooling rate effects on intensity determinations. They allow us to recover the geomagnetic intensity variations in the Middle East, between ∼7000 BC and ∼5000 BC, i.e. during the so-called pre-Halaf, proto-Halaf, Halaf and Halaf-Ubaid Transitional cultural phases. The data are compared with previous archeointensity results of similar ages from Northern Iraq (Yarim Tepe II and Tell Sotto) and Bulgaria. We find that previous dating of the Iraqi material was in error. When corrected, all northern Mesopotamian data show a relatively good consistency and also reasonably match with the Bulgarian archeointensity dataset. Using a compilation of available data, we construct a geomagnetic field intensity variation curve for the Middle East encompassing the past 9000 years, which makes it presently the longest known regional archeomagnetic intensity record. We further use this compilation to constrain variations in dipole field moment over most of the Holocene. In particular, we discuss the possibility that a significant dipole moment maximum occurred during the third millennium BC, which cannot easily be identified in available time-varying global geomagnetic field reconstructions
Pro-oxidant/antioxidant balance controls pancreatic β-cell differentiation through the ERK1/2 pathway

International audienceDuring embryogenesis, the intrauterine milieu affects cell proliferation, differentiation, and function by modifying gene expression in susceptible cells, such as the pancreatic β-cells. In this limited energy environment, mitochondrial dysfunction can lead to overproduction of reactive oxygen species (ROS) and to a decline in β-cell function. In opposition to this toxicity, ROS are also required for insulin secretion. Here we investigated the role of ROS in β-cell development. Surprisingly, decreasing ROS production in vivo reduced β-cell differentiation. Moreover, in cultures of pancreatic explants, progenitors were highly sensitive to ROS stimulation and responded by generating β-cells. ROS enhanced β-cell differentiation through modulation of ERK1/2 signaling. Gene transfer and pharmacological manipulations, which diminish cellular ROS levels, also interfered with normal β-cell differentiation. This study highlights the role of the redox balance on β-cell development and provides information that will be useful for improving β-cell production from embryonic stem cells, a step in cell therapy for diabetes
ANOVA decomposition of conditional Gaussian processes for sensitivity analysis with dependent inputs

International audienceComplex computer codes are widely used in science to model physical systems. Sensitivity analysis aims to measure the contributions of the inputs on the code output variability. An efficient tool to perform such analysis are the variance-based methods which have been recently investigated in the framework of dependent inputs. One of their issue is that they require a large number of runs for the complex simulators. To handle it, a Gaussian process regression model may be used to approximate the complex code. In this work, we propose to decompose a Gaussian process into a high dimensional representation. This leads to the definition of a variance-based sensitivity measure well tailored for non-independent inputs. We give a methodology to estimate these indices and to quantify their uncertainty. Finally, the approach is illustrated on toy functions and on a river flood model
Biomarkers of atherosclerosis and the potential of MRI for the diagnosis of vulnerable plaque.

Atherosclerosis is a chronic inflammatory vascular disease. As it is an inflammation process, many cellular and molecular events are involved at each step of the progression of atherosclerosis from an early fatty streak lesion to a highly dangerous rupture-prone plaque. Magnetic resonance imaging (MRI) is a well-established diagnostic tool for many kinds of chronic inflammation in various systems and organs, and recent improvements in spatial resolution and contrast strategies make it a promising technique for the characterization of inflammatory vessel walls. The first part of this review will briefly introduce the main cellular and molecular processes involved in atherosclerotic lesions; the second part will focus on the use of high-resolution MRI and present-generation contrast agents for plaque characterization; and the third part will present some recent and ongoing cellular and molecular MRI studies of atherosclerosis
Developing a Knowledge Management System Using an Ontological Approach in Global Organization

Part 6: Decision Making and Knowledge ManagementInternational audienceThis paper introduces an ontology-based knowledge model for knowledge management. This model can facilitate knowledge discovery that provides users with insight for decision making. The users requiring the insight normally play different roles with different requirements in an organization. To meet the requirements, insights are created by purposely aggregated transactional data. This involves a semantic data integration process. In this paper, we present a knowledge management system which is capable of representing knowledge requirements in a domain context and enabling the semantic data integration through ontology modeling. The knowledge domain context of United Bible Societies is used to illustrate the features of the knowledge management capabilities
The 'physical prophet' and the powers of the imagination. Part I
 : 
a case-study on prophecy, vapours and the imagination (1685 -1710)

published article: http://www.sciencedirect.com/science/article/pii/S1369848604000652International audienceI argue that the imagination was a crucial concept for the understanding of marvellous phenomena, divination and magic in general. Exploring a debate on prophecy at the turn of the seventeenth century, I show that four explanatory categories (God, demons, nature and fraud) were consistently evoked and I elucidate the role of the imagination in each of them. I introduce the term 'floating concept' to conceptualise the different understandings of the imagination and animal spirits in different discourses. I underpin my argument with a broader and less known discussion of the imagination. I argue that theories of the imagination, and particularly of the powers of the imagination, acquired negative associations and became linked with illicit magic in the Renaissance. Furthermore, I show that the relation between both animal spirits and imagination, and the power of the latter over external bodies, points to the importance of a 'history of vapours' and this suggests an adjustment to Hutchison's argument on occult qualities in mechanical philosophy. The accompanying paper (Vermeir, 2005) gives more evidence of these claims and elaborates on the relation between the natural and the moral
Travel and activity time allocation: An empirical comparison between eight cities in Europe

International audienceA study of daily time allocation to travel and out-of-home activity is conducted across eight European cities over three countries: France (Lyon, Grenoble, Strasbourg and Rennes), Switzerland (Geneva, Bern and Zurich) and Belgium (Brussels), based on individual travel survey data collected between 1997 and 2006. The effects of socio-demographic, spatial context, transport availability and city-specific variables are investigated thanks to the Cox proportional hazard model. The results indicate that socio-demographic characteristics and city (or country) specific effect play a major role while residential density and proximity to high level road or public transport networks have a very limited impact on time budgets for travel and out-of-home activities
Couple-centred testing and counselling for HIV serodiscordant heterosexual couples in sub-saharan Africa

In Africa, a large proportion of HIV infections occur within stable relationships, either because of prior infection of one of the partners or because of infidelity. Hence, there is an urgent need to define strategies to improve HIV prevention in a conjugal context. HIV counselling and testing have largely been organised within individual and sex-specific services such as prevention of mother-to-child transmission of HIV programs for women, or STI consultations for men. This does not facilitate the communication around the HIV status of each couple member and the adoption of preventive behaviours within the couple. One of the potential strategies is a couple-centred approach to HIV counselling and testing. In this paper, we first describe the stakes of HIV prevention within serodiscordant heterosexual couples in sub-Saharan Africa. We then systematically reviewed all couple-centred initiatives for HIV counselling and testing that have been evaluated in the scientific literature since the early nineties. It appears that despite positive results, such couple-oriented programs have not been implemented at a large scale. In order to further stimulate and strengthen HIV prevention efforts, renewed and increased attention is urgently required to identify and promote adequate prevention messages and programmes to improve HIV prevention behaviours in conjugal contexts
Role of endoplasmic reticulum stress in drug-induced toxicity

International audienceDrug-induced toxicity is a key issue for public health because some side effects can be severe and life-threatening. These adverse effects can also be a major concern for the pharmaceutical companies since significant toxicity can lead to the interruption of clinical trials, or the withdrawal of the incriminated drugs from the market. Recent studies suggested that endoplasmic reticulum (ER) stress could be an important event involved in drug liability, in addition to other key mechanisms such as mitochondrial dysfunction and oxidative stress. Indeed, drug-induced ER stress could lead to several deleterious effects within cells and tissues including accumulation of lipids, cell death, cytolysis, and inflammation. After recalling important information regarding drug-induced adverse reactions and ER stress in diverse pathophysiological situations, this review summarizes the main data pertaining to drug-induced ER stress and its potential involvement in different adverse effects. Drugs presented in this review are for instance acetaminophen (APAP), arsenic trioxide and other anticancer drugs, diclofenac, and different antiretroviral compounds. We also included data on tunicamycin (an antibiotic not used in human medicine because of its toxicity) and thapsigargin (a toxic compound of the Mediterranean plant Thapsia garganica) since both molecules are commonly used as prototypical toxins to induce ER stress in cellular and animal model
A laterally coupled UV210 polymer racetrack micro-resonator for thermal tunability and glucose sensing capability

International audienceWe report and demonstrate the feasibility of a laterally coupled racetrack microresonator based on UV210 photoresist to act as a thermal and glucose sensor. The large thermo-optic coefficient and the detection principle based on the interaction of the evanescent field with different glucose concentrations demonstrate that this sensor displays high sensitivity on detection properties. Deep-UV lithography procedures allow us to develop a laterally coupled microresonator with submicrometer patterns. The thermo-optic response of the racetrack microresonator is interrogated by using a NiCr alloy tip positioned on the top of the device. Temperatures ranging between 19 and 33ºC yield a red shift of the resonant wavelength with a linear sensitivity of 220 pm ºC-1. Additionally, the thermal tunability is successively demonstrated by covering the resonator with DI water. A blue shift of the resonant wavelength is obtained with a linear sensitivity of 200 pm ºC-1. The resonance optical properties under this top cladding conditions lead a Q-factor of 4000 with a finesse of 5.7. Glucose homogeneous sensing capability is also experimentally demonstrated. Different concentrations of glucose solutions result in a red shift of the resonant wavelengths with a linear sensitivity of 280 pm/(mg/ml). Finally, these results validate the laterally coupled racetrack microresonator as an operative photonic component for integrated optical devices such as optical filters applied on telecommunication, or transducer components devoted to assess biochemical interactions
From algal polysaccharides to cyclodextrins to stabilize a urease inhibitor.

International audienceN-Butyl-phosphorotriamide (NBPT) is a fertilizer widely used for its urease inhibiting properties. Nevertheless, formulations currently commercialized are complex and do not avoid severe decrease of activity due to the low stability of the bioactive compound under acidic conditions. According to its structure, NPBT was thought to be able to interact with both polar additives, by its phosphoramide function, and hydrophobic ones, through its alkyl chain. In this context, and in order to simplify formulations of this bioactive compound, a panel of natural polysaccharides was studied, including starch, β-(1,3)-glucans, carraghenans and alginates. We also used cyclodextrins, characterized the most stable inclusion complex with α-cyclodextrin and evaluated the stability of NBPT thus protected against hydrolysis under acidic conditions