High incidence of second basal cell skin cancers

We considered the risk of second basal cell cancers (BCC) of the skin using a population-based series of 1,868 BCC collected between 1976 and 1985 in the Swiss Cantons of Vaud and Neuchatel, and followed-up to the end of 2003. Overall, 507 second BCC were observed versus 59.98 expected, corresponding to a standardized incidence ratio (SIR) of 8.45 (95% CI: 7.73-9.22). The SIRs were similar in men and women in subsequent calendar periods, but tended to decline with advancing age at diagnosis of first BCC, from 13.98 below age 50 to 7.13 at age 70 or over. Consequently, the rate of first BCC increased to 30-fold between 7/100,000 at age 30-39 and 200/100,000 at age 70-79, but the rate of second BCC increased only about 3-fold between 31/1,000 at age 30-39 and 110/1,000 at age 70-79. The cumulative risk of second BCC was 11% at 5 years, 21% at 10 years and 40% at 20 years. This study indicates that the relative (but not the absolute) risk of second BCC is greater at younger age and declines with advancing age, and is therefore compatible with an excess baseline risk in a population of susceptible individuals. [Ed.]]]></dc:description>
   <dc:subject>Carcinoma, Basal Cell ;  Neoplasms, Second Primary ;  Skin Neoplasms</dc:subject>
</oai_dc:dc>
  </metadata>
</record>
<record xmlns="http://www.openarchives.org/OAI/2.0/">
  <header>
    <identifier>oai:serval.unil.ch:BIB_AF1638511ACD</identifier>
    <datestamp>2018-08-26T01:22:18Z</datestamp>
    <setSpec>openaire</setSpec>
    <setSpec>documents</setSpec>
    <setSpec>urnserval</setSpec>
  </header>
  <metadata>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
   <dc:identifier>https://serval.unil.ch/notice/serval:BIB_AF1638511ACD</dc:identifier>
   <dc:title>Neural correlates of motor abilities in 6 year old children born very preterm</dc:title>
   <dc:creator>MASMEJAN, S.</dc:creator>
   <dc:publisher>Université de Lausanne, Faculté de biologie et médecine</dc:publisher>
   <dc:type>info:eu-repo/semantics/masterThesis</dc:type>
   <dc:type>masterthesis</dc:type>
   <dc:date>2015</dc:date>
   <dc:description><![CDATA[Children born very preterm are at risk of neurodevelopment disabilities, among them developmental coordination disorders (DCD). The aim of this study was to evaluate the association of motor scores obtained through a validates and standardized test, and brain metrics, in a cohort of very preterm infants assessed at the age of 6 years. Our study includes 29 children born between 2001 and 2003 at the University Hospital of Lausanne. Neonatal data, clinical motor development test results, and euro-imaging data were collected. The following neonatal data were correlated to development scores: sex, birthweight, in utero growth restriction and multiple pregnancy. There was mainly a strong and significant association of cortical thickness in the orbital and frontal lobes with adaptive motor tasks. Frontal lobe is involved in the executive control of behavior with premotor areas. Occipital lobe includes several areas responsible for visual functions. Regression analysis showed no significant association of segmentation or cortical areas with motor scores. In conclusion these preliminary results suggest that there is an association between visual processing and motor development, and that early intervention on this could be considered in the management of development coordination disorder