pinecone/core-2020-05-10-deduplication huggingface dataset:
Pharmacological Inhibition of CB1Cannabinoid Receptor Protects Against Doxorubicin-Induced Cardiotoxicity

ObjectivesWe aimed to explore the effects of pharmacologic inhibition of cannabinoid-1 (CB1) receptor in in vivo and in vitro models of doxorubicin (DOX)-induced cardiotoxicity.BackgroundDoxorubicin is one of the most potent antitumor agents available; however, its clinical use is limited because of the risk of severe cardiotoxicity. Endocannabinoids mediate cardiodepressive effects through CB1receptors in various pathophysiological conditions, and these effects can be reversed by CB1antagonists.MethodsLeft ventricular function was measured by Millar pressure-volume system. Apoptosis markers, CB1/CB2receptor expression, and endocannabinoid levels were determined by immunohistochemistry, Western blot, reverse transcription-polymerase chain reaction, real-time polymerase chain reaction, flow cytometry, fluorescent microscopy, and liquid chromatography/in-line mass spectrometry techniques.ResultsFive days after the administration of a single dose of DOX (20 mg/kg intraperitoneally) to mice, left ventricular systolic pressure, maximum first derivative of ventricular pressure with respect to time (+dP/dt), stroke work, ejection fraction, cardiac output, and load-independent indexes of contractility (end-systolic pressure–volume relation, preload-recruitable stroke work, dP/dt–end-diastolic volume relation) were significantly depressed, and the myocardial level of the endocannabinoid anandamide (but not CB1/CB2receptor expression) was elevated compared with vehicle-treated control mice. Treatment with the CB1antagonists rimonabant or AM281 markedly improved cardiac dysfunction and reduced DOX-induced apoptosis in the myocardium. Doxorubicin also decreased cell viability and induced apoptosis in the H9c2 myocardial cell line measured by flow cytometry and fluorescent microscopy, which were prevented by the preincubation of the cells with either CB1antagonist, but not with CB1and CB2agonists and CB2antagonists.ConclusionsThese data suggest that CB1antagonists may represent a new cardioprotective strategy against DOX-induced cardiotoxicity
Singularities on the boundary of the stability domain near 1:1-resonance

AbstractWe study the linear differential equation x˙=Lx in 1:1-resonance. That is, x∈R4 and L is 4×4 matrix with a semi-simple double pair of imaginary eigenvalues (iβ,−iβ,iβ,−iβ). We wish to find all perturbations of this linear system such that the perturbed system is stable. Since linear differential equations are in one-to-one correspondence with linear maps we translate this problem to gl(4,R). In this setting our aim is to determine the stability domain and the singularities of its boundary. The dimension of gl(4,R) is 16, therefore we first reduce the dimension as far as possible. Here we use a versal unfolding of L, i.e. a transverse section of the orbit of L under the adjoint action of Gl(4,R). Repeating a similar procedure in the versal unfolding we are able to reduce the dimension to 4. A 3-sphere in this 4-dimensional space contains all information about the neighborhood of L in gl(4,R). Considering the 3-sphere as two 3-discs glued smoothly along their common boundary we find that the boundary of the stability domain is contained in two right conoids, one in each 3-disc. The singularities of this surface are transverse self-intersections, Whitney umbrellas and an intersection of self-intersections where the surface has a self-tangency. A Whitney stratification of the 3-sphere such that the eigenvalue configurations of corresponding matrices are constant on strata allows us to describe the neighborhood of L and in particular identify the stability domain
Mechanics of Polyropylene-Seed-Coat-Fibres Composites AndPolyropylene –Wood Fibres Composites-A Comparative Study

AbstractForestry by-products have potential applications as components of wood composites. Replacement of conventional pine radiata wood-fibres by the fibres from the seeds (SCF) of the by-products, require determining and optimizing the mechanical properties to producing highest quality products. Response to mechanical stress is an important aspect to consider towards partial or full replacement of the wood-fibres by SCFs. In the present study the critical strain energy release rate, and the fracture toughness are derived from the published data. The present work uses rules of mixture to derive the mechanical and the physical properties of the SCF and relates the performance of the composites of the wood-fibres and the SCF to chemical composition, dispersion, weight and Vf of the fibres. We have also derived the Gc, the critical strain energy release rate, KIC, the fracture toughness of the composites
Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function

Impaired ectodysplasin A (EDA) receptor (EDAR) signaling affects ectodermally derived structures including teeth, hair follicles, and cutaneous glands. The X-linked hypohidrotic ectodermal dysplasia (XLHED), resulting from EDA deficiency, can be rescued with lifelong benefits in animal models by stimulation of ectodermal appendage development with EDAR agonists. Treatments initiated later in the developmental period restore progressively fewer of the affected structures. It is unknown whether EDAR stimulation in adults with XLHED might have beneficial effects. In adult Eda mutant mice treated for several weeks with agonist anti-EDAR antibodies, we find that sebaceous gland size and function can be restored to wild-type levels. This effect is maintained upon chronic treatment but reverses slowly upon cessation of treatment. Sebaceous glands in all skin regions respond to treatment, although to varying degrees, and this is accompanied in both Eda mutant and wild-type mice by sebum secretion to levels higher than those observed in untreated controls. Edar is expressed at the periphery of the glands, suggesting a direct homeostatic effect of Edar stimulation on the sebaceous gland. Sebaceous gland size and sebum production may serve as biomarkers for EDAR stimulation, and EDAR agonists may improve skin dryness and eczema frequently observed in XLHED
Near-threshold measurement of the 4He(γ,n) reaction

AbstractA near-threshold 4He(γ,n) cross-section measurement has been performed at MAX-lab. Tagged photons from 23<Eγ<42 MeV were directed toward a liquid 4He target, and neutrons were detected by time-of-flight in two liquid-scintillator arrays. Seven-point angular distributions were measured for eight photon energies. The results are compared to experimental data measured at comparable energies and Recoil-Corrected Continuum Shell Model, Resonating Group Method, and recent Hyperspherical-Harmonic Expansion calculations. The angle-integrated cross-section data are peaked at a photon energy of about 28 MeV, in disagreement with the value recommended by Calarco, Berman, and Donnelly in 1983
Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation

SummaryModifications on histones or on DNA recruit proteins that regulate chromatin function. Here, we use nucleosomes methylated on DNA and on histone H3 in an affinity assay, in conjunction with a SILAC-based proteomic analysis, to identify “crosstalk” between these two distinct classes of modification. Our analysis reveals proteins whose binding to nucleosomes is regulated by methylation of CpGs, H3K4, H3K9, and H3K27 or a combination thereof. We identify the origin recognition complex (ORC), including LRWD1 as a subunit, to be a methylation-sensitive nucleosome interactor that is recruited cooperatively by DNA and histone methylation. Other interactors, such as the lysine demethylase Fbxl11/KDM2A, recognize nucleosomes methylated on histones, but their recruitment is disrupted by DNA methylation. These data establish SILAC nucleosome affinity purifications (SNAP) as a tool for studying the dynamics between different chromatin modifications and provide a modification binding “profile” for proteins regulated by DNA and histone methylation
Equivalence of polynomials under automorphisms of K[x,y]

AbstractLet K[x,y] be the algebra of polynomials in two variables over an arbitrary field K. We show that if the maximum of the x- and y-degrees of a given polynomial p(x,y) cannot be decreased by a single triangular or linear automorphism of K[x,y], then it cannot be decreased by any automorphism of K[x,y]. If K is an algebraically closed constructible field, this result yields an algorithm for deciding whether or not two polynomials p,q∈K[x,y] are equivalent under an automorphism of K[x,y].We also show that if there is an automorphism of K[x,y] taking p to q, then it is “almost” unique. More precisely: if an automorphism α of K[x,y] is not conjugate to a triangular or linear automorphism, then any polynomial invariant (or even semiinvariant) under α is a constant
Direct and Long-Range Action of a Wingless Morphogen Gradient

AbstractWingless (Wg), a founding member of the Wingless/Int-1 (Wnt) family of secreted proteins, acts as a short-range inducer and as a long-range organizer during Drosophila development. Here, we determine the consequences of ectopically expressing (i) a wild-type form of Wg, (ii) a membrane-tethered form of Wg, and (iii) a constitutively active form of the cytosolic protein Armadillo (Arm), which normally acts to transduce Wg, and we compare them with the effects of removing endogenous Wg or Arm activity. Our results indicate that wild-type Wg acts at long range, up-regulating the transcription of particular target genes as a function of concentration and distance from secreting cells. In contrast, tethered Wg and Arm have only short-range or autonomous effects, respectively, on the transcription of these genes. We interpret these findings as evidence that Wg can act directly and at long range as a gradient morphogen during normal development
The production and decay of the top partner T in the left–right twin Higgs model at the ILC and CLIC

AbstractThe left–right twin Higgs model (LRTHM) predicts the existence of the top partner T. In this work, we make a systematic investigation for the single and pair production of this top partner T through the processes: e+e−→tT¯+Tt¯ and TT¯, the neutral scalar (the SM-like Higgs boson h or neutral pseudoscalar boson ϕ0) associate productions e+e−→tT¯h+Tt¯h, TT¯h, tT¯ϕ0+Tt¯ϕ0 and TT¯ϕ0. From the numerical evaluations for the production cross sections and relevant phenomenological analysis we find that (a) the production rates of these processes, in the reasonable parameter space, can reach the level of several or tens of femtobarns; (b) for some cases, the peak value of the resonance production cross section can be enhanced significantly and reaches to the level of pb; (c) the subsequent decay of T→ϕ+b→tb¯b may generate typical phenomenological features rather different from the signals from other new physics models beyond the standard model (SM); and (d) since the relevant SM background is generally not large, some signals of the top partner T predicted by the LRTHM may be detectable in the future ILC and CLIC experiments
Probing the CP nature of the Higgs boson at linear colliders with τ spin correlations; the case of mixed scalar–pseudoscalar couplings

AbstractThe prospects for the measurement of the pseudoscalar admixture in the hττ coupling to a Standard Model Higgs boson of 120 GeV mass are discussed in a quantitative manner for e+e− collisions of 350 GeV centre-of-mass energy. Specific angular distributions in the h→τ+τ−, τ±→ρ±ν̄τ(ντ) decay chain can be used to probe mixing angles of scalar–pseudoscalar hττ couplings. In the discussion of the feasibility of the method, assumptions on the properties of a future detector for an e+e− linear collider such as TESLA are used. The Standard Model Higgsstrahlung production process is taken as an example. For the expected performance of a typical linear collider set-up, the sensitivity of a measurement of the scalar–pseudoscalar mixing angle turned out to be 6°. It will be straightforward to apply our results to estimate the sensitivity of a measurement, in cases another scenario of the Higgs boson sector (Standard Model or not) is chosen by nature. The experimental error of the method is expected to be limited by the statistics
Exclusive processes in electron–ion collisions

AbstractThe exclusive processes in electron–ion (eA) interactions are an important tool to investigate the QCD dynamics at high energies as they are in general driven by the gluon content of the target which is strongly subject to parton saturation effects. In this Letter we compute the cross sections for the exclusive vector meson production as well as the deeply virtual Compton scattering (DVCS) relying on the color dipole approach and considering the numerical solution of the Balitsky–Kovchegov equation including running coupling corrections (rcBK). The production cross sections obtained with the rcBK solution and bCGC parametrization are very similar, the former being slightly larger
Niemann–Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway

AbstractThe link between cholesterol and Alzheimer's disease has recently been revealed in Niemann–Pick type C disease. We found that NPC1−/− cells show decreased expression of APP at the cell surface and increased processing of APP through the β-secretase pathway resulting in increased C99, sAPPβ and intracellular Aβ40 levels. This effect is dependent on increased cholesterol levels, since cholesterol depletion reversed cell surface APP expression and lowered Aβ/C99 levels in NPC1−/− cells to the levels observed in wt cells. Finding that overexpression of C99, a direct γ-secretase substrate, does not lead to increased intracellular Aβ levels in NPC1−/− cells vs. CHOwt suggests that the effect on intracellular Aβ upon cholesterol accumulation in NPC1−/− cells is not due to increased APP cleavage by γ-secretase. Our results indicate that cholesterol may modulate APP processing indirectly by modulating APP expression at the cell surface and thus its cleavage by β-secretase
Male-on-male sexual assault: victim, offender and offence characteristics

Unlike male-on-female sexual assaults, little is known about the nature of male-on-male sexual assault, especially in terms of victim, offender and offence characteristics. The present paper systematically reviews the limited research into male-on-male sexual offences in order to ascertain the current state of knowledge with regards to these issues. An extensive search resulted in the identification of 15 empirical studies, with a total of 5,112 cases of male-on-male sexual assaults, for inclusion in the analyses. Findings revealed that, in the main, both victims and offenders of this type of offence tend to be young and heterosexual. Offenders tend to act alone during the assault and to be previously acquainted with the victim. Most male-on-male sexual assaults are violent in nature, taking place in either the victim's or the offender's home. Victims are subjected to various sexual acts, with anal penetration being the most frequent, and victims are frequently forced to perform oral sex on the offender. The implications of these findings, as well as limitations of the reviewed studies and directions for future research, are discussed
Ad-Creativity, Internal Consumer Response, and\ud
Purchase Intention: An Evaluation upon Ardiles\ud
“Flash Mom” TV Ad

This research aim to analyse the effects Ad-creativity, Internal\ud
Consumer Response, and Purchase Intention as an evaluation upon\ud
Ardiles’ “Flash Mom” TV ad. The research used 100 housewives as the\ud
sample respondents. The respondents were chosen when they were taking\ud
their children to go to some primary schools in Surabaya. Each of them\ud
were shown the ardiles’ advertisement entitled “flash mom” twice and then\ud
they were asked to answer the questionare. The research variable Ad-\ud
Creativity as the independent variable consist of Divergence dimention\ud
which is measured by five indicators and Relevance dimention which is\ud
measured by three indicators. Internal Consumer Response as the\ud
mediation variable consist of cognitive and affective response dimentions,\ud
which each of them is measured by three indicators. Three indicators\ud
measure the Purchase Intention as the dependent variable. This research\ud
use Partial Least Square (PLS) as the quantitative analysis tool. The results\ud
prove that there are positive effect from Ad-Creativity to Internal\ud
Consumer Response, there are positive effect on Internal Consumer\ud
Response to Purchase Intention, and there are positive effect on Ad-\ud
Creativity to Purchase Intention
Consistent dust and gas models for protoplanetary disks: II. Chemical
  networks and rates

Aims. We define a small and large chemical network which can be used for the
quantitative simultaneous analysis of molecular emission from the near-IR to
the submm. We revise reactions of excited molecular hydrogen, which are not
included in UMIST, to provide a homogeneous database for future applications.
Methods. We use the thermo-chemical disk modeling code ProDiMo and a standard T
Tauri disk model to evaluate the impact of various chemical networks, reaction
rate databases and sets of adsorption energies on a large sample of chemical
species and emerging line fluxes from the near-IR to the submm wavelength
range. Results. We find large differences in the masses and radial distribution
of ice reservoirs when considering freeze-out on bare or polar ice coated
grains. Most strongly the ammonia ice mass and the location of the snow line
(water) change. As a consequence molecules associated to the ice lines such as
N2H+ change their emitting region; none of the line fluxes in the sample
considered here changes by more than 25% except CO isotopologues, CN and N2H+
lines. The three-body reaction N+H2+M plays a key role in the formation of
water in the outer disk. Besides that, differences between the UMIST 2006 and
2012 database change line fluxes in the sample considered here by less than a
factor 2 (a subset of low excitation CO and fine structure lines stays even
within 25%); exceptions are OH, CN, HCN, HCO+ and N2H+ lines. However,
different networks such as OSU and KIDA 2011 lead to pronounced differences in
the chemistry inside 100 au and thus affect emission lines from high excitation
CO, OH and CN lines. H2 is easily excited at the disk surface and
state-to-state reactions enhance the abundance of CH+ and to a lesser extent
HCO+. For sub-mm lines of HCN, N2H+ and HCO+, a more complex larger network is
recommended. ABBREVIATEDComment: accepted for publication in A&
Search for direct top squark pair production in events with a Higgs or Z boson, and missing transverse momentum in √s=13 TeV pp collisions with the ATLAS detector

A search for direct top squark pair production resulting in events with either a same-flavour opposite-sign dilepton pair with invariant mass compatible with a Z boson or a pair of jets compatible with a Standard Model (SM) Higgs boson (h) is presented. Requirements on the missing transverse momentum, together with additional selections on leptons, jets, jets identified as originating from b-quarks are imposed to target the other decay products of the top squark pair. The analysis is performed using proton-proton collision data at s√=13 TeV collected with the ATLAS detector at the LHC in 2015–2016, corresponding to an integrated luminosity of 36.1 fb−1. No excess is observed in the data with respect to the SM predictions. The results are interpreted in two sets of models. In the first set, direct production of pairs of lighter top squarks (t~1) with long decay chains involving Z or Higgs bosons is considered. The second set includes direct pair production of the heavier top squark pairs (t~2) decaying via t~2→Zt~1 or t~2→ht~1. The results exclude at 95% confidence level t~2 and t~1 masses up to about 800 GeV, extending the exclusion region of supersymmetric parameter space covered by previous LHC searches
The nature and distribution of flowing features in a weakly karstified porous limestone aquifer\ud

The nature and distribution of flowing features in boreholes in an area of approximately 400 km2 in a weakly karstic porous limestone aquifer (the Chalk) was investigated using single borehole dilution tests (SBDTs) and borehole imaging. One-hundred and twenty flowing features identified from SBDTs in 24 boreholes have densities which decrease from ∼0.3 m−1 near the water table to ∼0.07 m−1 at depths of more than 40 m below the water table; the average density is 0.20 m−1. There is some evidence of regional lithological control and borehole imaging of three boreholes indicated that most flowing features are associated with marls, hardgrounds and flints that may be developed at a more local scale.\ud
\ud
Borehole imaging also demonstrated that many flowing features are solutionally enlarged fractures, suggesting that even in carbonate aquifers where surface karst is developed on only a small scale, groundwater flow is still strongly influenced by dissolution. Fully connected solutional pathways can occur over 100s, sometimes 1000s of metres. However, conduits, tubules and fissures may not always be individually persistent along a flowpath, instead being connected together and also connected to unmodified fractures to create a relatively dense network of voids with variable apertures (<0.1 cm to >15 cm). Groundwater therefore moves along flowpaths made up of voids with varying shape and character. Local solutional development of fractures at significant depths below the surface suggests that mixing corrosion and in situ sources of acidity may contribute to solutional enhancement of fractures.\ud
\ud
The study demonstrates that single borehole dilution testing is a useful method of obtaining a large dataset of flowing features at catchment-regional scales. The Chalk is a carbonate aquifer with small-scale surface karst development and this study raises the question of whether other carbonate aquifers with small-scale surface karst have similar characteristics, and what hydrological role small-scale dissolutional features play in highly karstic aquifers
Observation of a new boson with mass near 125 GeV in pp collisions at √=7 and 8 TeV

A detailed description is reported of the analysis used by the CMS Collaboration in the search for the standard model Higgs boson in pp collisions at the LHC, which led to the observation of a new boson. The data sample corresponds to integrated luminosities up to 5.1 fb-1 at √=7 TeV, and up to 5.3 fb-1 at √ s=8 TeV. The results for five Higgs boson decay modes γγ, ZZ, WW, ττ, and bb, which show a combined local significance of 5 standard deviations near 125 GeV, are reviewed. A fit to the invariant mass of the two high resolution channels, γγ and ZZ → 4ℓ, gives a mass estimate of 125.3 ± 0.4 (stat.) ± 0.5 (syst.) GeV. The measurements are interpreted in the context of the standard model Lagrangian for the scalar Higgs field interacting with fermions and vector bosons. The measured values of the corresponding couplings are compared to the standard model predictions. The hypothesis of custodial symmetry is tested through the measurement of the ratio of the couplings to the W and Z bosons. All the results are consistent, within their uncertainties, with the expectations for a standard model Higgs boson. [Figure not available: see fulltext.] © 2013 CERN for the benefit of the CMS collaboration.The Scientific and Technical Research Council of Turkey, and Turkish Atomic Energy Authorit