pinecone/core-2020-05-10-deduplication huggingface dataset:
Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment

SummaryBackgroundHigh blood pressure, blood glucose, serum cholesterol, and BMI are risk factors for cardiovascular diseases and some of these factors also increase the risk of chronic kidney disease and diabetes. We estimated mortality from cardiovascular diseases, chronic kidney disease, and diabetes that was attributable to these four cardiometabolic risk factors for all countries and regions from 1980 to 2010.MethodsWe used data for exposure to risk factors by country, age group, and sex from pooled analyses of population-based health surveys. We obtained relative risks for the effects of risk factors on cause-specific mortality from meta-analyses of large prospective studies. We calculated the population attributable fractions for each risk factor alone, and for the combination of all risk factors, accounting for multicausality and for mediation of the effects of BMI by the other three risks. We calculated attributable deaths by multiplying the cause-specific population attributable fractions by the number of disease-specific deaths. We obtained cause-specific mortality from the Global Burden of Diseases, Injuries, and Risk Factors 2010 Study. We propagated the uncertainties of all the inputs to the final estimates.FindingsIn 2010, high blood pressure was the leading risk factor for deaths due to cardiovascular diseases, chronic kidney disease, and diabetes in every region, causing more than 40% of worldwide deaths from these diseases; high BMI and glucose were each responsible for about 15% of deaths, and high cholesterol for more than 10%. After accounting for multicausality, 63% (10·8 million deaths, 95% CI 10·1–11·5) of deaths from these diseases in 2010 were attributable to the combined effect of these four metabolic risk factors, compared with 67% (7·1 million deaths, 6·6–7·6) in 1980. The mortality burden of high BMI and glucose nearly doubled from 1980 to 2010. At the country level, age-standardised death rates from these diseases attributable to the combined effects of these four risk factors surpassed 925 deaths per 100 000 for men in Belarus, Kazakhstan, and Mongolia, but were less than 130 deaths per 100 000 for women and less than 200 for men in some high-income countries including Australia, Canada, France, Japan, the Netherlands, Singapore, South Korea, and Spain.InterpretationThe salient features of the cardiometabolic disease and risk factor epidemic at the beginning of the 21st century are high blood pressure and an increasing effect of obesity and diabetes. The mortality burden of cardiometabolic risk factors has shifted from high-income to low-income and middle-income countries. Lowering cardiometabolic risks through dietary, behavioural, and pharmacological interventions should be a part of the global response to non-communicable diseases.FundingUK Medical Research Council, US National Institutes of Health
Graphical Verification of a Spatial Logic for the π-calculus

AbstractThe paper introduces a novel approach to the verification of spatial properties for finite π-calculus specifications. The mechanism is based on a recently proposed graphical encoding for mobile calculi: Each process is mapped into a (ranked) graph, such that the denotation is fully abstract with respect to the usual structural congruence (i.e., two processes are equivalent exactly when the corresponding encodings yield the same graph). Spatial properties for reasoning about the behavior and the structure of π-calculus processes are then expressed in a logic introduced by Caires, and they are verified on the graphical encoding of a process, rather than on its textual representation. More precisely, the graphical presentation allows for providing a simple and easy to implement verification algorithm based on the graphical encoding (returning true if and only if a given process verifies a given spatial formula)
Signal Integration by the IκB Protein Pickle Shapes Drosophila Innate Host Defense

SummaryPattern recognition receptors are activated following infection and trigger transcriptional programs important for host defense. Tight regulation of NF-κB activation is critical to avoid detrimental and misbalanced responses. We describe Pickle, a Drosophila nuclear IκB that integrates signaling inputs from both the Imd and Toll pathways by skewing the transcriptional output of the NF-κB dimer repertoire. Pickle interacts with the NF-κB protein Relish and the histone deacetylase dHDAC1, selectively repressing Relish homodimers while leaving other NF-κB dimer combinations unscathed. Pickle’s ability to selectively inhibit Relish homodimer activity contributes to proper host immunity and organismal health. Although loss of pickle results in hyper-induction of Relish target genes and improved host resistance to pathogenic bacteria in the short term, chronic inactivation of pickle causes loss of immune tolerance and shortened lifespan. Pickle therefore allows balanced immune responses that protect from pathogenic microbes while permitting the establishment of beneficial commensal host-microbe relationships
The neural bases of the pseudohomophone effect: Phonological constraints on lexico-semantic access in reading

AbstractWe investigated phonological processing in normal readers to answer the question to what extent phonological recoding is active during silent reading and if or how it guides lexico-semantic access. We addressed this issue by looking at pseudohomophone and baseword frequency effects in lexical decisions with event-related functional magnetic resonance imaging (fMRI). The results revealed greater activation in response to pseudohomophones than for well-controlled pseudowords in the left inferior/superior frontal and middle temporal cortex, left insula, and left superior parietal lobule. Furthermore, we observed a baseword frequency effect for pseudohomophones (e.g., FEAL) but not for pseudowords (e.g., FEEP). This baseword frequency effect was qualified by activation differences in bilateral angular and left supramarginal, and bilateral middle temporal gyri for pseudohomophones with low- compared to high-frequency basewords. We propose that lexical decisions to pseudohomophones involves phonology-driven lexico-semantic activation of their basewords and that this is converging neuroimaging evidence for automatically activated phonological representations during silent reading in experienced readers
Dynamically generated 1+ heavy mesons

AbstractBy using a heavy chiral unitary approach, we study the S wave interactions between heavy vector meson and light pseudoscalar meson. By searching for poles of the unitary scattering amplitudes in the appropriate Riemann sheets, several 1+ heavy states are found. In particular, a D∗K bound state with a mass of 2.462±0.010 GeV which should be associated with the recently observed Ds1(2460) state is obtained. In the same way, a B∗K¯ bound state (Bs1) with mass of 5.778±0.007 GeV in the bottom sector is predicted. The spectra of the dynamically generated D1 and B1 states in the I=1/2 channel are also calculated. One broad state and one narrow state are found in both the charmed and bottom sectors. The coupling constants and decay widths of the predicted states are further investigated
Energies, group-invariant kernels and numerical integration on compact manifolds

AbstractThe purpose of this paper is to derive quadrature estimates on compact, homogeneous manifolds embedded in Euclidean spaces, via energy functionals associated with a class of group-invariant kernels which are generalizations of zonal kernels on the spheres or radial kernels in euclidean spaces. Our results apply, in particular, to weighted Riesz kernels defined on spheres and certain projective spaces. Our energy functionals describe both uniform and perturbed uniform distribution of quadrature point sets
Exact cosmological solutions of f(R) theories via Hojman symmetry

AbstractNowadays, f(R) theory has been one of the leading modified gravity theories to explain the current accelerated expansion of the universe, without invoking dark energy. It is of interest to find the exact cosmological solutions of f(R) theories. Besides other methods, symmetry has been proved as a powerful tool to find exact solutions. On the other hand, symmetry might hint the deep physical structure of a theory, and hence considering symmetry is also well motivated. As is well known, Noether symmetry has been extensively used in physics. Recently, the so-called Hojman symmetry was also considered in the literature. Hojman symmetry directly deals with the equations of motion, rather than Lagrangian or Hamiltonian, unlike Noether symmetry. In this work, we consider Hojman symmetry in f(R) theories in both the metric and Palatini formalisms, and find the corresponding exact cosmological solutions of f(R) theories via Hojman symmetry. There exist some new solutions significantly different from the ones obtained by using Noether symmetry in f(R) theories. To our knowledge, they also have not been found previously in the literature. This work confirms that Hojman symmetry can bring new features to cosmology and gravity theories
Status of the Gribov–Pontecorvo solution to the solar neutrino problem

AbstractWe discuss the status of the Gribov–Pontecorvo (GP) solution to the solar neutrino problem. This solution naturally appears in bimaximal neutrino mixing and reduces the solar and atmospheric neutrino problems to vacuum oscillations of three active neutrinos. The GP solution predicts an energy-independent suppression of the solar neutrino flux. It is disfavoured by the rate of the Homestake detector, but its statistical significance greatly improves, when the chlorine rate and the boron neutrino flux are slightly rescaled, and when the Super-Kamiokande neutrino spectrum is included in the analysis. Our results show that rescaling of the chlorine signal by only 10% is sufficient for the GP solution to exist, if the boron–neutrino flux is taken 10–20% lower than the SSM prediction. The regions allowed for the GP solution in the parameter space are found and observational signatures of this solution are discussed
Differential neuroprotection by A1 receptor activation and A2A receptor inhibition following pilocarpine-induced status epilepticus

AbstractAiming at a better understanding of the role of A2A in temporal lobe epilepsy (TLE), we characterized the effects of the A2A antagonist SCH58261 (7-(2-phenylethyl)-5-amino-2(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine) on seizures and neuroprotection in the pilocarpine model. The effects of SCH58261 were further analyzed in combination with the A1 agonist R-Pia (R(−)-N6-(2)-phenylisopropyl adenosine). Eight groups were studied: pilocarpine (Pilo), SCH+Pilo, R-Pia+Pilo, R-Pia+SCH+Pilo, Saline, SCH+Saline, R-Pia+Saline, and R-Pia+SCH+Saline. The administration of SCH58261, R-Pia, and R-Pia+SCH58261 prior to pilocarpine increased the latency to SE, and decreased either the incidence of or rate of mortality from SE compared with controls. Administration of R-Pia and R-Pia+SCH58261 prior to pilocarpine reduced the number of Fluoro-Jade B-stained cells in the hippocampus and piriform cortex when compared with control. This study showed that pretreatment with R-Pia and SCH58261 reduces seizure occurrence, although only R-Pia has neuroprotective properties. Further studies are needed to clarify the neuroprotective role of A2A in TLE
The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy

Contains fulltext :
                  173051.pdf (publisher's version ) (Open Access)Major depression, currently the world's primary cause of disability, leads to profound personal suffering and increased risk of suicide. Unfortunately, the success of antidepressant treatment varies amongst individuals and can take weeks to months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for the most severely depressed and when standard treatments fail, produces a more rapid response and remains the most effective intervention for severe depression. Exploring the neurobiological effects of ECT is thus an ideal approach to better understand the mechanisms of successful therapeutic response. Though several recent neuroimaging studies show structural and functional changes associated with ECT, not all brain changes associate with clinical outcome. Larger studies that can address individual differences in clinical and treatment parameters may better target biological factors relating to or predictive of ECT-related therapeutic response. We have thus formed the Global ECT-MRI Research Collaboration (GEMRIC) that aims to combine longitudinal neuroimaging as well as clinical, behavioral and other physiological data across multiple independent sites. Here, we summarize the ECT sample characteristics from currently participating sites, and the common data-repository and standardized image analysis pipeline developed for this initiative. This includes data harmonization across sites and MRI platforms, and a method for obtaining unbiased estimates of structural change based on longitudinal measurements with serial MRI scans. The optimized analysis pipeline, together with the large and heterogeneous combined GEMRIC dataset, will provide new opportunities to elucidate the mechanisms of ECT response and the factors mediating and predictive of clinical outcomes, which may ultimately lead to more effective personalized treatment approaches
A Harmonized Dataset on Global Educational Attainment between 1970 and 2060 – An Analytical Window into Recent Trends and Future Prospects in Human Capital Development

We hereby present a dataset produced at the Wittgenstein Centre (WIC) containing comprehensive time series on educational attainment and mean years of schooling (MYS). The dataset is split by 5-year age groups and sex for 171 countries and covers the period between 1970 and 2010. It also contains projections of educational attainment to 2060 based on several scenarios of demographic and educational development. The dataset is constructed around collected and harmonized empirical census and survey data sets for the projection base year. The paper presents the principles and methodology associated with the reconstruction and the projection, and how it differs from several previous exercises. It also proposes a closer look at the diffusion of education in world regions and how the existing gaps in terms of generation, gender, and geography have been evolving in the last 40 years
Mandatory infectious diseases consultation for MRSA bacteremia is associated with reduced mortality.

OBJECTIVES: Although infectious disease (ID) consultation has been associated with lower mortality in Staphylococcus aureus bloodstream infections, it is still not mandatory in many centers. This study aimed at assessing the impact of ID consultation on diagnostic and therapeutic management of methicillin-resistant S. aureus (MRSA) bacteremia.
METHODS: Retrospective cohort study of all patients with MRSA bacteremia from 2001 to 2010. ID consultations were obtained on request between 2001 and 2006 and became mandatory since 2007.
RESULTS: 156 episodes of MRSA bacteremia were included, mostly from central venous catheter (32%) and skin and soft tissue (19%) infections. ID consultation coverage was 58% between 2001 and 2006 and 91% between 2007 and 2010. ID consultation was associated with more echocardiography (59% vs. 26%, p &lt; 0.01), vancomycin trough level measurements (99% vs. 77%, p &lt; 0.01), follow-up blood cultures (71% vs. 50%, p = 0.05), deep-seated infections (43% vs. 16%, p &lt; 0.01), more frequent infection source control (83% vs. 57%, p = 0.03), a longer duration of MRSA-active therapy (median and IQR: 17 days, 13-30, vs. 12, 3-14, p &lt; 0.01) and a 20% reduction in 7-day, 30-day and in-hospital mortality.
CONCLUSIONS: ID consultation was associated with a better management of patients with MRSA bacteremia and a reduced mortality
TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Deregulated cathepsin proteolysis occurs across numerous cancers, but in vivo substrates mediating tumorigenesis remain ill-defined. Applying 8-plex iTRAQ terminal amine isotopic labeling of substrates (TAILS), a systems-level N-terminome degradomics approach, we identified cathepsin B, H, L, S, and Z in vivo substrates and cleavage sites with the use of six different cathepsin knockout genotypes in the Rip1-Tag2 mouse model of pancreatic neuroendocrine tumorigenesis. Among 1,935 proteins and 1,114 N termini identified by TAILS, stable proteolytic products were identified in wild-type tumors compared with one or more different cathepsin knockouts (17%-44% of 139 cleavages). This suggests a lack of compensation at the substrate level by other cathepsins. The majority of neo-N termini (56%-83%) for all cathepsins was consistent with protein degradation. We validated substrates, including the glycolytic enzyme pyruvate kinase M2 associated with the Warburg effect, the ER chaperone GRP78, and the oncoprotein prothymosin-alpha. Thus, the identification of cathepsin substrates in tumorigenesis improves the understanding of cathepsin functions in normal physiology and cancer
Measurement of spin correlations in tt production using the matrix element method in the muon+jets final state in pp collisions at √s=8 TeV

The consistency of the spin correlation strength in top quark pair production with the standard model (SM) prediction is tested in the muon+jets final state. The events are selected from pp collisions, collected by the CMS detector, at a centre-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 19.7 fb-1. The data are compared with the expectation for the spin correlation predicted by the SM and with the expectation of no correlation. Using a template fit method, the fraction of events that show SM spin correlations is measured to be 0.72±0.08(stat)+0.15 -0.13(syst), representing the most precise measurement of this quantity in the muon+jets final state to date.The Scientific and Technical Research Council of Turkey, and Turkish Atomic Energy Authorit
Cost-effectiveness of community-based screening and treatment
                for chronic hepatitis B in The Gambia: an economic modelling
                analysis.

Background: Despite the high burden of hepatitis B virus (HBV) infection in sub-Saharan Africa, absence of widespread screening and poor access to treatment leads to most people remaining undiagnosed until later stages of disease when prognosis is poor and treatment options are limited. We examined the cost-effectiveness of community-based screening and early treatment with antiviral therapy for HBV in The Gambia. Methods: In this economic evaluation, we combined a decision tree with a Markov state transition model to compare a screen and treat intervention consisting of adult community-based screening using a hepatitis B surface antigen (HBsAg) rapid test and subsequent HBV antiviral therapy versus current practice, in which there is an absence of publicly provided screening or treatment for HBV. We used data from the PROLIFICA study to parameterise epidemiological, primary screening, and cost information, and other model parameter inputs were obtained from a literature search. Outcome measures were cost per disability-adjusted life-year (DALY) averted; cost per life-year saved; and cost per quality-adjusted life-year (QALY) gained. We calculated the incremental cost-effectiveness ratios (ICERs) between current practice and the screen and treat intervention. Costs were assessed from a health provider perspective. Costs (expressed in 2013 US$) and health outcomes were discounted at 3% per year. Findings: In The Gambia, where the prevalence of HBsAg is 8·8% in people older than 30 years, adult screening and treatment for HBV has an incremental cost-effectiveness ratio (ICER) of $540 per DALY averted, $645 per life-year saved, and $511 per QALY gained, compared with current practice. These ICERs are in line with willingness-to-pay levels of one times the country's gross domestic product per capita ($487) per DALY averted, and remain robust over a wide range of epidemiological and cost parameter inputs. Interpretation: Adult community-based screening and treatment for HBV in The Gambia is likely to be a cost-effective intervention. Higher cost-effectiveness might be achievable with targeted facility-based screening, price reductions of drugs and diagnostics, and integration of HBV screening with other public health interventions
A Proposal for "Correction Values" for Winter Outdoor Design Temperatures

This study aims to find a correlation between winter and outdoor design temperature (WDT) and mass of the building envelope. The daily variations of the inside temperatures and heat fluxes of the walls under various climatic conditions and differant wall constructions have been calculated by a computer program based on the response factor technique, which uses variable outside air temperature and solar radiation and constant inside air temperature values as input climate data. The analysis of the relation between mass of the walls and inside surface heat fluxes resulted with the correction values for winter design temperature (WDTCV) depending on the mass of the wall and on the direction of facades for differant climatic zones
Distribution of future location vector and residual sum of squares for multivariate location-scale model with spherically contoured errors

The multivariate location-scale  model with a family of
  spherically contoured errors is considered for both realized and
future responses.
 The predictive distributions of the
future location vector (FLV) and future residual sum of squares
(FRSS) for the future responses are  obtained. Conditional on the
realized responses, the FLV follows a multivariate Student-t
distribution whose shape parameter  depends on the sample size and
the dimension of the location parameters of the model, and the
FRSS follows a scaled beta distribution. The   results obtained by
both the classical and Bayesian methods under uniform prior are
identical. This paper generalizes the results for location-scale
models with multivariate normal and Student-t models to a wider
family of spherically/ellipticcally contoured models
Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient.

Morphogen gradients control body pattern by differentially regulating cellular behavior. Here, we analyze the molecular events underlying the primary response to the Dpp/BMP morphogen in Drosophila. Throughout development, Dpp transduction causes the graded transcriptional downregulation of the brinker (brk) gene. We first provide significance for the brk expression gradient by showing that different Brk levels repress distinct combinations of wing genes expressed at different distances from Dpp-secreting cells. We then dissect the brk regulatory region and identify two separable elements with opposite properties, a constitutive enhancer and a Dpp morphogen-regulated silencer. Furthermore, we present genetic and biochemical evidence that the brk silencer serves as a direct target for a protein complex consisting of the Smad homologs Mad/Medea and the zinc finger protein Schnurri. Together, our results provide the molecular framework for a mechanism by which the extracellular Dpp/BMP morphogen establishes a finely tuned, graded read-out of transcriptional repression