pinecone/core-2020-05-10-deduplication huggingface dataset:
A multiplex microsatellite set for non-invasive genotyping and sexing of the osprey (Pandion haliaetus).

The online version of this article (doi:10.1007/s12686-015-0497-4) contains supplementary material, which is available to authorized users.During the 1950s and 1970s the osprey (Pandion haliaetus) experienced a dramatic population crash and remains of conservation concern in several parts of the world. We isolated 37 microsatellite loci and assessed these in ospreys sampled in the UK and Norway (using mouth swabs/feathers). From 26 loci variable in four ospreys, we selected 13, combined these into two multiplex-PCR sets and included a sex-typing marker. Additional markers confirmed sexes. In 17 ospreys, feather-sampled in central Norway, we found 3-10 alleles per locus. The 13 loci are autosomal (heterozygotes were present in both sexes) and observed heterozygosities ranged from 0.24 to 0.94. The combined probability of identity for the 13 loci was 8.0 × 10(-12). These microsatellite loci will be useful for genetic monitoring, parentage analysis and population genetic studies of the osprey.This study was funded by the Natural Environment Research Council, UK, coauthors institutions, an Erasmus Internship (TS) and the County administration in Nord-Trøndelag, Norway.Peer-reviewedPublisher Versio
African-European contacts in the Kongo kingdom (sixteenth-eighteenth centuries) : new archaeological insights from Ngongo Mbata (lower Congo, DRC)

Ngongo Mbata, the main and most affluent center of the Kongo kingdom’s
Mbata province in the seventeenth century, is well known from the historical sources, but 
virtually unexplored in archaeological publications. Ngongo Mbata is unique in that it
hosted a monumental stone building about which the historical record remains silent. This
makes it particularly challenging from the point of view of historical archaeology. In this
paper historical data, unpublished excavation results from the 1930s and our own
fieldwork undertaken in 2012–13 are brought together, to tell a new story of early
African-European contacts in the interior of West Central Africa.http://link.springer.com/journal/107612016-09-30hb201
Inverse barocaloric effects in ferroelectric BaTiO3 ceramics

We use calorimetry to identify pressure-driven isothermal entropy changes in ceramic samples of the prototypical ferroelectric BaTiO3. Near the structural phase transitions at ~400 K (cubic-tetragonal) and ~280 K (tetragonal-orthorhombic), the inverse barocaloric response differs in sign and magnitude from the corresponding conventional electrocaloric response. The differences in sign arise due to the decrease in unit-cell volume on heating through the transitions, whereas the differences in magnitude arise due to the large volumetric thermal expansion on either side of the transitions.Peer ReviewedPostprint (published version
Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells

SummaryVα24 invariant natural killer T (iNKT) cells are a subset of T lymphocytes implicated in the regulation of broad immune responses. They recognize lipid antigens presented by CD1d on antigen-presenting cells and induce both innate and adaptive immune responses, which enhance effective immunity against cancer. Conversely, reduced iNKT cell numbers and function have been observed in many patients with cancer. To recover these numbers, we reprogrammed human iNKT cells to pluripotency and then re-differentiated them into regenerated iNKT cells in vitro through an IL-7/IL-15-based optimized cytokine combination. The re-differentiated iNKT cells showed proliferation and IFN-γ production in response to α-galactosylceramide, induced dendritic cell maturation and downstream activation of both cytotoxic T lymphocytes and NK cells, and exhibited NKG2D- and DNAM-1-mediated NK cell-like cytotoxicity against cancer cell lines. The immunological features of re-differentiated iNKT cells and their unlimited availability from induced pluripotent stem cells offer a potentially effective immunotherapy against cancer
Solar Powered Heat Storage for Injera Baking in Ethiopia

AbstractEthiopia with a population of about 85 million meets 96% of its energy needs with bio-mass, charcoal, wood, animal dung and plant residues. More than 50% of this energy goes entirely on baking Injera. Injera the national food of the country demands 180-220°C to be well cooked. In this article; Injera baking with solar energy on off-focus system, status of electric powered stove and the potential for solar powered stoves is discussed. The research and development of solar thermal for household energy consumption has not been well developed and adopted. One reason for this is that the system can only be used outdoor and at time of sun shine. In addition to the off-focus solar thermal application this paper discussed the integration of solar thermal with heat storage for a sustainable future use. The prototype for direct steam based baking was developed and tested in Mekelle University (Ethiopia) and Phase change material based heat storage prototype was developed and tested at NTNU. Both experiments showed the possibility of solar energy for Injera baking and its sustainability by including latent heat storage. This research gave hope to break the bottleneck related with on- focus solar cookers
Probing the quark–gluon interaction with hadrons

AbstractWe present a unified picture of mesons and baryons in the Dyson–Schwinger/Bethe–Salpeter approach, wherein the quark–gluon and quark–(anti)quark interactions follow from a systematic truncation of the QCD effective action and include all its tensor structures. The masses of some of the ground-state mesons and baryons are found to be in reasonable agreement with the expectations of a ‘quark-core calculation’, suggesting a partial insensitivity to the details of the quark–gluon interaction. However, discrepancies remain in the meson sector, and for excited baryons, that suggest higher order corrections are relevant and should be investigated following the methods outlined herein
κ-deformed covariant quantum phase spaces as Hopf algebroids

AbstractWe consider the general D=4 (10+10)-dimensional κ-deformed quantum phase space as given by Heisenberg double H of D=4 κ-deformed Poincaré–Hopf algebra H. The standard (4+4)-dimensional κ-deformed covariant quantum phase space spanned by κ-deformed Minkowski coordinates and commuting momenta generators (xˆμ,pˆμ) is obtained as the subalgebra of H. We study further the property that Heisenberg double defines particular quantum spaces with Hopf algebroid structure. We calculate by using purely algebraic methods the explicit Hopf algebroid structure of standard κ-deformed quantum covariant phase space in Majid–Ruegg bicrossproduct basis. The coproducts for Hopf algebroids are not unique, determined modulo the coproduct gauge freedom. Finally we consider the interpretation of the algebraic description of quantum phase spaces as Hopf algebroids
Predicting microbial water quality with models: Over-arching questions for managing risk in agricultural catchments

AbstractThe application of models to predict concentrations of faecal indicator organisms (FIOs) in environmental systems plays an important role for guiding decision-making associated with the management of microbial water quality. In recent years there has been an increasing demand by policy-makers for models to help inform FIO dynamics in order to prioritise efforts for environmental and human-health protection. However, given the limited evidence-base on which FIO models are built relative to other agricultural pollutants (e.g. nutrients) it is imperative that the end-user expectations of FIO models are appropriately managed. In response, this commentary highlights four over-arching questions associated with: (i) model purpose; (ii) modelling approach; (iii) data availability; and (iv) model application, that must be considered as part of good practice prior to the deployment of any modelling approach to predict FIO behaviour in catchment systems. A series of short and longer-term research priorities are proposed in response to these questions in order to promote better model deployment in the field of catchment microbial dynamics
A recombinant fusion protein containing a spider toxin specific for the insect voltage-gated sodium ion channel shows oral toxicity towards insects of different orders

AbstractRecombinant fusion protein technology allows specific insecticidal protein and peptide toxins to display activity in orally-delivered biopesticides. The spider venom peptide δ-amaurobitoxin-PI1a, which targets insect voltage-gated sodium channels, was fused to the “carrier” snowdrop lectin (GNA) to confer oral toxicity.The toxin itself (PI1a) and an amaurobitoxin/GNA fusion protein (PI1a/GNA) were produced using the yeast Pichia pastoris as expression host. Although both proteins caused mortality when injected into cabbage moth (Mamestra brassicae) larvae, the PI1a/GNA fusion was approximately 6 times as effective as recombinant PI1a on a molar basis. PI1a alone was not orally active against cabbage moth larvae, but a single 30 μg dose of the PI1a/GNA fusion protein caused 100% larval mortality within 6 days when fed to 3rd instar larvae, and caused significant reductions in survival, growth and feeding in 4th – 6th instar larvae. Transport of fusion protein from gut contents to the haemolymph of cabbage moth larvae, and binding to the nerve chord, was shown by Western blotting. The PI1a/GNA fusion protein also caused mortality when delivered orally to dipteran (Musca domestica; housefly) and hemipteran (Acyrthosiphon pisum; pea aphid) insects, making it a promising candidate for development as a biopesticide
Human and mouse homologs of the Saccharomyces cerevisiaeRAD54 DNA repair gene: evidence for functional conservation

AbstractBackground: Homologous recombination is of eminent importance both in germ cells, to generate genetic diversity during meiosis, and in somatic cells, to safeguard DNA from genotoxic damage. The genetically well-defined RAD52 pathway is required for these processes in the yeast Saccharomyces cerevisiae. Genes similar to those in the RAD52 group have been identified in mammals. It is not known whether this conservation of primary sequence extends to conservation of function.Results Here we report the isolation of cDNAs encoding a human and a mouse homolog of RAD54. The human (hHR54) and mouse (mHR54) proteins were 48% identical to Rad54 and belonged to the SNF2/SWI2 family, which is characterized by amino-acid motifs found in DNA-dependent ATPases. The hHR54 gene was mapped to chromosome 1p32, and the hHR54 protein was located in the nucleus. We found that the levels of hHR54 mRNA increased in late G1 phase, as has been found for RAD54 mRNA. The level of mHR54 mRNA was elevated in organs of germ cell and lymphoid development and increased mHR54 expression correlated with the meiotic phase of spermatogenesis. The hHR54 cDNA could partially complement the methyl methanesulfonate-sensitive phenotype of S. cerevisiaerad54Δ cells.Conclusion The tissue-specific expression of mHR54 is consistent with a role for the gene in recombination. The complementation experiments show that the DNA repair function of Rad54 is conserved from yeast to humans. Our findings underscore the fundamental importance of DNA repair pathways: even though they are complex and involve multiple proteins, they seem to be functionally conserved throughout the eukaryotic kingdom
Hydrogen lines in LAMOST low-resolution spectra of RR Lyrae stars

AbstractThe LAMOST pilot survey has produced a data release containing over 600,000 stellar spectra. By cross-checking with a large time series photometric database of RR Lyrae stars in high Galactic latitude regions, we found a total number of 157 RR Lyrae stars that have been observed with LAMOST. In this sample, we successfully captured three RR Lyrae stars in the fast expansion phase, all of them showing hypersonic shock wave features in the Balmer line region. We fit the shape of Hα line region and determine that the emission feature seen within the broadened Hα absorption line suggests hypersonic relative motion in the atmospheres of these three objects. With a further LAMOST survey of millions of stars, we plan to capture a large sample of RR Lyrae stars in their hypersonic expansion phase, and therefore provide a large database for the study of the internal structure and the pulsation mechanism of RR Lyrae stars
Isometry theorem for the Segal–Bargmann transform on a noncompact symmetric space of the complex type

AbstractWe consider the Segal–Bargmann transform on a noncompact symmetric space of the complex type. We establish isometry and surjectivity theorems for the transform, in a form as parallel as possible to the results in the dual compact case. The isometry theorem involves integration over a tube of radius R in the complexification, followed by analytic continuation with respect to R. A cancellation of singularities allows the relevant integral to have a nonsingular extension to large R, even though the function being integrated has singularities
Tag–probe labeling methods for live-cell imaging of membrane proteins

AbstractInstead of using reconstituted proteoliposomes, in situ investigations of membrane proteins in living cell membranes are important because the heterogeneous and dynamic nature of biomembranes significantly affects their behavior. Protein-specific labeling is a key technique for the detection of a target protein by fluorescence measurements, particularly fluorescence microscopy. However, conventional genetic fusion with fluorescent proteins has several shortcomings. Post-translational labeling methods using a genetically encodable tag and synthetic probes targeting to the tag can overcome these limitations. This review summarizes emerging tag–probe techniques for labeling specific membrane proteins and their applications, including endocytotic internalization, partitioning to specific membrane domains, interprotein interactions, and conformational changes
Sociodemographic predictors of latent class membership of problematic and disordered gamblers

AbstractThis paper reports a series of analyses examining the predictors of gambling subtypes identified from a latent class analysis of problem gambling assessment data, pooled from four health and gambling surveys conducted in Britain between 2007 and 2012. Previous analyses have indicated that gambling assessments have a consistent three class structure showing quantitative and potentially qualitative differences. Bringing this data together is useful for studying more severe problem gamblers, where the small number of respondents has been a chronic limitation of gambling prevalence research. Predictors were drawn from sociodemographic indicators and engagement with other legal addictive behaviours, namely smoking and alcohol consumption. The pooled data was entered into a multinomial logistic regression model in which class membership was regressed along a series of demographic variables and survey year, based on previous analyses of gambling prevalence data. The results identified multiple demographic differences (age, general health, SES, being single, membership of ethnic minority groups) between the non-problem and two classes endorsing some problem gambling indicators. Although these two groups tended to share a sociodemographic profile, the odds of being male, British Asian and a smoker increased between the three groups in line with problem gambling severity. Being widowed was also found to be associated with the most severe gambling class. A number of associations were also observed with other addictive behaviours. However these should be taken as indicative as these were limited subsamples of a single dataset. These findings identify specific groups in which gambling problems are more prevalent, and highlight the importance of the interaction between acute and determinant aspects of impulsivity, suggesting that a more complex account of impulsivity should be considered than is currently present in the gambling literature
f0(1710) production in exclusive B decays

AbstractProduction of f0(1710), a theoretical endeavor of pure scalar glueball state, is studied in detail from exclusive rare B decay within the framework of perturbative QCD. The branching fraction for B±→K∗±f0(1710)→K∗±(KK¯) is estimated to be about 8×10−6, while for B±→K±f0(1710)→K±(KK¯) it is smaller by roughly an order of magnitude. With the accumulation of almost 1 billion BB¯ pairs from the BaBar and Belle experiments to date, hunting for a scalar glueball via these rare decay modes should be attainable
Substance use in young adults with ADHD: Comorbidity and symptoms of inattention and hyperactivity/impulsivity

AbstractYoung adults with attention deficit hyperactivity disorder (ADHD) are at high risk of substance use (SU). The aims of the current study were: 1) to examine the use of alcohol, tobacco, marijuana and other illegal drugs by adults with and without ADHD; 2) to compare the oppositional, conduct, anxiety, depression, sleep and antisocial personality symptoms of ADHD adults with SU and ADHD adults without SU; 3) to examine the ability of ADHD symptoms and conduct problems to predict SU. A total of 93 young adults, 43 without ADHD and 50 with a childhood diagnosis of ADHD, who were part of the Spanish sample of the Multicenter ADHD Genetics (IMAGE) study, collaborated in a follow-up evaluation 10.1 years later. ADHD participants were divided into two groups based on the presence or absence of SU. Statistically significant differences were found between young adults with and without ADHD in their use of tobacco, marijuana and alcohol. A statistically significant association was also shown between externalization problems and a greater risk of SU. Conduct problems, to a greater degree than ADHD symptoms, affect SU in ADHD adults
B-type lamins in health and disease

AbstractFor over two decades, B-type lamins were thought to have roles in fundamental processes including correct assembly of nuclear envelopes, DNA replication, transcription and cell survival. Recent studies have questioned these roles and have instead emphasised the role of these proteins in tissue building and tissue integrity, particularly in tissues devoid of A-type lamins. Other studies have suggested that the expression of B-type lamins in somatic cells influences the rate of entry into states of cellular senescence. In humans duplication of the LMNB1 gene (encoding lamin B1) causes an adult onset neurodegenerative disorder, termed autosomal dominant leukodystrophy, whilst very recently, LMNB1 has been implicated as a susceptibility gene in neural tube defects. This is consistent with studies in mice that reveal a critical role for B-type lamins in neuronal migration and brain development. In this review, I will consider how different model systems have contributed to our understanding of the functions of B-type lamins and which of those functions are critical for human health and disease
LHC constraints on the Lee–Wick Higgs sector

AbstractWe determine constraints on the Lee–Wick Higgs sector obtained from the full LHC Higgs boson data set. We determine the current lower bound on the heavy neutral Lee–Wick scalar, as well as projected bounds at a 14 TeV LHC with 300 and 3000 inverse femtobarns of integrated luminosity. We point out that the first sign of new physics in this model may be the observation of a deviation from standard model expectations of the lighter neutral Higgs signal strengths corresponding to production via gluon–gluon fusion and decay to either tau or Z pairs. The signal strength of the latter is greater than the standard model expectation, unlike most extensions of the standard model
Cumulative incidence of entry into out-of-home care: Changes over time in Denmark and England

AbstractPolicies and thresholds vary for placing children into out-of-home care (OHC) at different ages. Evidence is lacking that quantifies the risk of entering OHC by age, and how this varies over time and between countries. We determined the age-specific cumulative incidence of ever entering OHC during childhood in Denmark and in eight local authorities in England. We used administrative data for any form of OHC (except respite care) provided by children's social services in Denmark and England from 1992 to 2008. Using life tables and national population estimates, we calculated the cumulative incidence of entry into OHC by year of age for cohorts born in 1992–1994 through to 2006–2008. The cumulative incidence of entry into OHC decreased over time in Denmark and increased in England at all ages. Cumulative incidence of OHC in the first year of life was similar in Denmark and England for infants born in 1992–1994 (Denmark 2.83/1,000, England 2.89/1,000), but infants born in 2007–2008 were nearly three times as likely to enter OHC before their first birthday in England (4.50/1,000) than in Denmark (1.61/1,000). Entry into OHC during adolescence was more common in Denmark than in England so that by 16 years old the cumulative incidence of ever entering OHC during childhood was twice as high in Denmark (33.83/1,000) as in England (15.62/1,000). Diverging trends over time in the use of OHC in Denmark and England are likely to reflect changing policies in the two countries
Pure gravity mediation and spontaneous B–L breaking from strong dynamics

AbstractIn pure gravity mediation (PGM), the most minimal scheme for the mediation of supersymmetry (SUSY) breaking to the visible sector, soft masses for the standard model gauginos are generated at one loop rather than via direct couplings to the SUSY-breaking field. In any concrete implementation of PGM, the SUSY-breaking field is therefore required to carry nonzero charge under some global or local symmetry. As we point out in this note, a prime candidate for such a symmetry might be B–L, the Abelian gauge symmetry associated with the difference between baryon number B and lepton number L. The F-term of the SUSY-breaking field then not only breaks SUSY, but also B–L, which relates the respective spontaneous breaking of SUSY and B–L at a fundamental level. As a particularly interesting consequence, we find that the heavy Majorana neutrino mass scale ends up being tied to the gravitino mass, ΛN∼m3/2. Assuming nonthermal leptogenesis to be responsible for the generation of the baryon asymmetry of the universe, this connection may then explain why SUSY necessarily needs to be broken at a rather high energy scale, so that m3/2≳1000 TeV in accord with the concept of PGM. We illustrate our idea by means of a minimal model of dynamical SUSY breaking, in which B–L is identified as a weakly gauged flavor symmetry. We also discuss the effect of the B–L gauge dynamics on the superparticle mass spectrum as well as the resulting constraints on the parameter space of our model. In particular, we comment on the role of the B–L D-term