pinecone/core-2020-05-10-deduplication huggingface dataset:
When will cyclogenesis commence given a favorable tropical environment?

The article of record as published may be located at http://dx.doi.org/10.1016/j.piutam.2015.06.010A numerical diagnosis of tropical cyclogenesis in a quiescent, rotating environment is presented to suggest an answer to the
above question. Our research approach employs near-cloud-resolving numerical simulations to quantitatively analyze helical selforganization
of moist-convective atmospheric turbulence. The simulations permit a diagnosis of cyclogenesis when the primary
and secondary circulations in a forming hurricane vortex become linked by special convective coherent structures – Vortical Hot
Towers (VHTs). The VHTs are argued to be intrinsic elements of the turbulent vortex dynamo in the tropical atmosphere of the
Earth. It is discussed how the generated linkage makes the nascent vortex an integral helical system, supporting a positive
feedback between the circulations. The feedback is sustained by only modest fluxes of latent heat from the underlying ocean,
convective instability and vortical convection. The feedback indicates a release of potential energy that is converted into kinetic
energy of developing large-scale helical vortex. Energy exchange between the primary and secondary circulation and their further
mutual intensification is inferred from the numerical experiments.This work was supported by the Russian Academy of Sciences (OEMMPU Program 12-T-1-1008), and the U.S. National Science Foundation under grant ATM-0733380
Path integral Monte Carlo calculation of momentum distribution in solid He-4

We perform calculations of the momentum distribution n(k) in solid 4He by means of path integral Monte Carlo methods.We see that, in perfect crystals, n(k)does not depend on temperature T and that is different from the classical Gaussian\ud
shape of the Maxwell-Boltzmann distribution, even though these discrepancies decrease\ud
when the density of the system increases. In crystals presenting vacancies, we see that for T ≥ 0.75 K, n(k) presents the same behavior as in the perfect crystal, but,\ud
at lower T , it presents a peak when k→0.Peer ReviewedPostprint (author’s final draft
Changing climate and nutrient transfers:Evidence from high temporal resolution concentration-flow dynamics in headwater catchments

We hypothesise that climate change, together with intensive agricultural systems, will increase the transfer of pollutants from land to water and impact on stream health. This study builds, for the first time, an integrated assessment of nutrient transfers, bringing together a) high-frequency data from the outlets of two surface water-dominated, headwater (~10 km2) agricultural catchments, b) event-by-event analysis of nutrient transfers, c) concentration duration curves for comparison with EU Water Framework Directive water quality targets, d) event analysis of location-specific, sub-daily rainfall projections (UKCP, 2009), and e) a linear model relating storm rainfall to phosphorus load. These components, in combination, bring innovation and new insight into the estimation of future phosphorus transfers, which was not available from individual components. The data demonstrated two features of particular concern for climate change impacts. Firstly, the bulk of the suspended sediment and total phosphorus (TP) load (greater than 90% and 80% respectively) was transferred during the highest discharge events. The linear model of rainfall-driven TP transfers estimated that, with the projected increase in winter rainfall (+8% to +17% in the catchments by 2050s), annual event loads might increase by around 9% on average, if agricultural practices remain unchanged. Secondly, events following dry periods of several weeks, particularly in summer, were responsible for high concentrations of phosphorus, but relatively low loads. The high concentrations, associated with low flow, could become more frequent or last longer in the future, with a corresponding increase in the length of time that threshold concentrations (e.g. for water quality status) are exceeded. The results suggest that in order to build resilience in stream health and help mitigate potential increases in diffuse agricultural water pollution due to climate change, land management practices should target controllable risk factors, such as soil nutrient status, soil condition and crop cover
Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer.

PMCID: PMC3542622Failure to efficiently induce apoptosis contributes to cisplatin resistance in non-small-cell lung cancer (NSCLC). Although BCL-2-associated X protein (BAX) and BCL-2 antagonist killer (BAK) are critical regulators of the mitochondrial apoptosis pathway, their requirement has not been robustly established in relation to cisplatin. Here, we show that cisplatin can efficiently bypass mitochondrial apoptosis block caused by loss of BAX and BAK, via activation of the extrinsic death receptor pathway in some model cell lines. Apoptosis resistance following cisplatin can only be observed when both extrinsic and intrinsic pathways are blocked, consistent with redundancy between mitochondrial and death receptor pathways in cisplatin-induced apoptosis. In H460 NSCLC cells, caspase-8 cleavage was shown to be induced by cisplatin and is dependent on death receptor 4, death receptor 5, Fas-associated protein with death domain, acid sphingomyelinase and ceramide synthesis. In contrast, cisplatin-resistant cells fail to activate caspase-8 via this pathway despite conserving sensitivity to death ligand-driven activation. Accordingly, caspase-8 activation block acquired during cisplatin resistance, can be bypassed by death receptor agonism.Peer-reviewedPublisher Versio
Do banks really monitor? : Evidence from CEO succession decisions

The authors are grateful to Dick Davies, Paul Draper, Robert Faff, David Hillier, Ike Mathur (the editor), Katrin Migliorati, Krishna Paudyal, our anonymous reviewer, and to seminar participants at the 2nd International Conference of the Financial Engineering and Banking Society (London) and 2013 Midwest Finance Association Annual Meeting (Chicago) for helpful comments on earlier versions of this work. We also thank Martin Kemmitt for helpful research assistance on this project. All errors remain our own.Peer reviewedPostprin
Dynamic modelling reveals the separable contributions to achieving correct spindle orientation in a noisy system

The mechanisms by which the mammalian mitotic spindle is guided to a predefined orientation through microtubule-cortex interactions have recently received considerable interest, but there has been no dynamic model that describes spindle movements towards the preferred axis in human cells. Here, we develop a dynamic model based on stochastic activity of cues anisotropically positioned around the cortex of the mitotic cell and we show that the mitotic spindle does not reach equilibrium prior to chromosome segregation. Our model successfully captures the characteristic experimental behaviour of noisy spindle rotation dynamics in human epithelial cells, including a weak underlying bias in the direction of rotation, suppression of motion close to the alignment axis, and the effect of the aspect ratio of the interphase cell shape in defining the final alignment axis. We predict that the force exerted per cue has a value which minimizes the deviation of the spindle from the predefined axis. The model has allowed us to systematically explore the parameter space around experimentally relevant configurations, and predict the mechanistic function of a number of established regulators of spindle orientation, highlighting how physical modelling of a noisy system can lead to functional biological understanding. We provide key insights into measurable parameters in live-cells that can help distinguish between mechanisms of microtubule and cortical-cue interactions that jointly control the final orientation of the spindle.This work was supported by Cancer Research UKThis is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.bpj.2015.08.01
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension

Recent studies have demonstrated that the expression of sphingosine kinase 1, the enzyme that catalyses formation of the bioactive lipid, sphingosine 1-phosphate, is increased in lungs from patients with pulmonary arterial hypertension. In addition, Sk1-/- mice are protected from hypoxic-induced pulmonary arterial hypertension. Therefore, we assessed the effect of the sphingosine kinase 1 selective inhibitor, PF-543 and a sphingosine kinase 1/ceramide synthase inhibitor, RB-005 on pulmonary and cardiac remodeling in a mouse hypoxic model of pulmonary arterial hypertension. Administration of the potent sphingosine kinase 1 inhibitor, PF-543 in a mouse hypoxic model of pulmonary hypertension had no effect on vascular remodeling but reduced right ventricular hypertrophy. The latter was associated with a significant reduction in cardiomyocyte death. The protection involves a reduction in the expression of p53 (that promotes cardiomyocyte death) and an increase in the expression of anti-oxidant nuclear factor (erythroid-derived 2)-like 2 (Nrf-2). In contrast, RB-005 lacked effects on right ventricular hypertrophy, suggesting that SK1 inhibition might be nullified by concurrent inhibition of ceramide synthase. Therefore, our findings with PF-543 suggest an important role for SK1 in the development of hypertrophy in PAH
Search for the lepton-flavour violating decay $D^0 \to e^\pm\mu^\mp$

A search for the lepton-flavour violating decay $D^0 \to e^\pm \mu^\mp$ is
made with a dataset corresponding to an integrated luminosity of 3.0 fb$^{-1}$
of proton-proton collisions at centre-of-mass energies of $7$ TeV and $8$ TeV,
collected by the LHCb experiment. Candidate $D^0$ mesons are selected using the
decay $D^{*+} \to D^0 \pi^+$ and the $D^0 \to e^\pm \mu^\mp$ branching fraction
is measured using the decay mode $D^0 \to K^-\pi^+$ as a normalisation channel.
No significant excess of $D^0 \to e^\pm \mu^\mp$ candidates over the expected
background is seen, and a limit is set on the branching fraction,
$\mathcal{B}(D^0 \to e^\pm \mu^\mp) < 1.3 \times 10^{-8}$, at 90 % confidence
level. This is an order of magnitude lower than the previous limit and it
further constrains the parameter space in some leptoquark models and in
supersymmetric models with R-parity violation.Comment: All figures and tables, along with any supplementary material and
  additional information, are available at
  https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2015-048.htm
The Spin-dependent Structure Function of the Proton $g_{1}^p$ and a Test of the Bjorken Sum Rule

The inclusive double-spin asymmetry, $A_{1}^{p}$, has been measured at COMPASS in deepinelastic polarised muon scattering off a large polarised NH3 target. The data, collected in the year 2007, cover the range Q2 > 1 (GeV/c)^2, 0.004 < x < 0.7 and improve the statistical precision of g_{1}^{p}(x) by a factor of two in the region x < 0.02. The new proton asymmetries are combined with those previously published for the deuteron to extract the non-singlet spin-dependent structure function g_1^NS(x,Q2). The isovector quark density, Delta_q_3(x,Q2), is evaluated from a NLO QCD fit of g_1^NS. The first moment of Delta_q3 is in good agreement with the value predicted by the Bjorken sum rule and corresponds to a ratio of the axial and vector coupling constants g_A/g_V = 1.28+-0.07(stat)+-0.10(syst).The inclusive double-spin asymmetry, A_1^p, has been measured at COMPASS in deepinelastic polarised muon scattering off a large polarised NH3 target. The data, collected in the year 2007, cover the range Q2 > 1 (GeV/c)^2, 0.004 < x < 0.7 and improve the statistical precision of g_1^p(x) by a factor of two in the region x < 0.02. The new proton asymmetries are combined with those previously published for the deuteron to extract the non-singlet spin-dependent structure function g_1^NS(x,Q2). The isovector quark density, Delta_q_3(x,Q2), is evaluated from a NLO QCD fit of g_1^NS. The first moment of Delta_q3 is in good agreement with the value predicted by the Bjorken sum rule and corresponds to a ratio of the axial and vector coupling constants g_A/g_V = 1.28+-0.07(stat)+-0.10(syst).The inclusive double-spin asymmetry, A1p , has been measured at COMPASS in deep-inelastic polarised muon scattering off a large polarised NH 3 target. The data, collected in the year 2007, cover the range Q2>1(GeV/c)2 , 0.004<x<0.7 and improve the statistical precision of g1p(x) by a factor of two in the region x<0.02 . The new proton asymmetries are combined with those previously published for the deuteron to extract the non-singlet spin-dependent structure function g1NS(x,Q2) . The isovector quark density, Δq3(x,Q2) , is evaluated from a NLO QCD fit of g1NS . The first moment of Δq3 is in good agreement with the value predicted by the Bjorken sum rule and corresponds to a ratio of the axial and vector coupling constants |gA/gV|=1.28±0.07(stat.)±0.10(syst.)
Search for baryon number violation in top-quark decays

A search for baryon number violation (BNV) in top-quark decays is performed using pp collisions produced by the LHC at √s = 8 TeV. The top-quark decay considered in this search results in one light lepton (muon or electron), two jets, but no neutrino in the final state. Data used for the analysis were collected by the CMS detector and correspond to an integrated luminosity of 19.5 fb−1. The event selection is optimized for top quarks produced in pairs, with one undergoing the BNV decay and the other the standard model hadronic decay to three jets. No significant excess of events over the expected yield from standard model processes is observed. The upper limits at 95% confidence level on the branching fraction of the BNV top-quark decay are calculated to be 0.0016 and 0.0017 for the muon and the electron channels, respectively. Assuming lepton universality, an upper limit of 0.0015 results from the combination of the two channels. These limits are the first that have been obtained on a BNV process involving the top quark
Analytical approach to neuromarketing as a business strategy

The aim of this paper is to analyze the theoretical and methodological approaches to the study of neuro- marketing for designing business strategies. The initial question is based on incorporating advances in neuro-marketing to the field of strategic direction. The research method used is to review the literature to study this phenomenon. The main conclusion is that neuro-marketing allows us to know the customer's reactions in terms of brain activation without the need to appeal to the report of his conscious experience. In consequence the firms will be able to develop capacities and valuable resources to create focal strategies
Enhanced Graph Rewriting Systems for Complex Software Domain

International audienceMethodologies for correct by construction reconfigurations can efficiently solve consistency issues in dynamic software architecture. Graph-based models are appropriate for designing such architectures and methods. At the same time, they may be unfit to characterize a system from a non functional perspective. This stems from efficiency and applicability limitations in handling time-varying characteristics and their related dependencies. In order to lift these restrictions, an extension to graph rewriting systems is proposed herein. The suitability of this approach, as well as the restraints of currently available ones, are illustrated, analysed and experimentally evaluated with reference to a concrete example. This investigation demonstrates that the conceived solution can: (i) express any kind of algebraic dependencies between evolving requirements and properties; (ii) significantly ameliorate the efficiency and scalability of system modifications with respect to classic methodologies; (iii) provide an efficient access to attribute values; (iv) be fruitfully exploited in software management systems; (v) guarantee theoretical properties of a grammar, like its termination
Enhancements to the it GW space-time method

We describe the following new features which significantly enhance the power of the recently developed real-space imaginary-time GW scheme (Rieger et al., Comp. Phys. Commun. 117, 211 (1999)) for the calculation of self-energies and related quantities of solids: (i) to fit the smoothly decaying time/energy tails of the dynamically screened Coulomb interaction and other quantities to model functions, treating only the remaining time/energy region close to zero numerically and performing the Fourier transformation from time to energy and vice versa by a combination of analytic integration of the tails and Gauss-Legendre quadrature of the remaining part and (ii) to accelerate the convergence of the band sum in the calculation of the Green's function by replacing higher unoccupied eigenstates by free electron states (plane waves). These improvements make the calculation of larger systems (surfaces, clusters, defects etc.) accessible
Implementation of Operators via Filter Banks; Hardy Wavelets and Autocorrelation Shell

International audienceWe consider implementation of operators via filter banks in the framework of the Mul-tiresolution Analysis. Our method is particularly efficient for convolution operators. Although our method of applying operators to functions may be used with any wavelet basis with a sufficient number of vanishing moments, we distinguish two particular settings, namely, orthogonal bases, and the autocorrelation shell. We apply our method to evaluate the Hilbert transform of signals and derive a fast algorithm capable of achieving any given accuracy. We consider the case where the wavelet is the autocorrelation function of another wavelet associated with an orthonormal basis and where our method provides a fast algorithm for the computation of the modulus and the phase of signals. Moreover, the resulting wavelet may be viewed as being (approximately, but with any given accuracy) in the Hardy space H 2 (IR)
Equational characterization of Boolean function classes

Cataloged from PDF version of article.Several noteworthy classes of Boolean functions can be characterized by algebraic identities (e.g. the class of positive functions consists of all functions f satisfying the identity f(x) V f(y) V f(x V y) = f(x V y)). We give algebraic identities for several of the most frequently analyzed classes of Boolean functions (including Horn, quadratic, supermodular, and submodular functions) and proceed then to the general question of which classes of Boolean functions can be characterized by algebraic identities. We answer this question for function classes closed under addition of inessential (irrelevant) variables. Nearly all classes of interest have this property. We show that a class with this property has a characterization by algebraic identities if and only if the class is closed under the operation of variable identification. Moreover, a single identity suffices to characterize a class if and only if the number of minimal forbidden identification minors is finite. Finally, we consider characterizations by general first-order sentences, rather than just identities. We show that a class of Boolean functions can be described by an appropriate set of such first-order sentences if and only if it is closed under permutation of variables. © 2000 Elsevier Science B.V. All rights reserved
A search for high-mass resonances decaying to τ+τ− in pp collisions at s√=7 TeV with the ATLAS detector

This Letter presents a search for high-mass resonances decaying into τ+τ− final states using proton–proton collisions at View the MathML source produced by the Large Hadron Collider. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 4.6 fb−1. No statistically significant excess above the Standard Model expectation is observed; 95% credibility upper limits are set on the cross section times branching fraction of Z′ resonances decaying into τ+τ− pairs as a function of the resonance mass. As a result, Z′ bosons of the Sequential Standard Model with masses less than 1.40 TeV are excluded at 95% credibility.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET and ERC, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT, Greece; ISF, MINERVA, GIF, DIP and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America
The impact of persuasive messages on IAT performance is moderated by source attractiveness and likeability

In two studies, participants read persuasive messages introduced by an attractive (Study 1) or likeable (Study 2) source before completing measures of implicit and explicit evaluations. The persuasive messages were in favor of an unfamiliar brand of facial soap (Study 1) and the implementation of comprehensive examinations at the participants' university (Study 2). Results showed that persuasive messages had a stronger impact on an Implicit Association Test when the source was high in attractiveness or likeability (Study 1 and Study 2); responses on an Affect Misattribution Procedure, though in the predicted direction, were not significantly impacted by a source high in likeability (Study 2). These findings parallel those of numerous studies that, however, have looked almost exclusively at persuasion of explicit evaluations. They confirm that implicit evaluations can be changed through direct persuasive appeals and provide new information about the conditions under which persuasion of implicit evaluations can be found
ANALYTICAL FORMULAE OF MOLECULAR ION ABUNDANCES AND THE N2H+ RING IN PROTOPLANETARY DISKS

We investigate the chemistry of ion molecules in protoplanetary disks, motivated by the detection of the N2H+ ring around TW Hya. While the ring inner radius coincides with the CO snow line, it is not apparent why N2H+ is abundant outside the CO snow line in spite of the similar sublimation temperatures of CO and N2. Using the full gas-grain network model, we reproduced the N2H+ ring in a disk model with millimeter grains. The chemical conversion of CO and N2 to less volatile species (sink effect hereinafter) is found to affect the N2H+ distribution. Since the efficiency of the sink depends on various parameters such as activation barriers of grain-surface reactions, which are not well constrained, we also constructed the no-sink model; the total (gas and ice) CO and N2 abundances are set constant, and their gaseous abundances are given by the balance between adsorption and desorption. Abundances of molecular ions in the no-sink model are calculated by analytical formulae, which are derived by analyzing the full-network model. The N2H+ ring is reproduced by the no-sink model, as well. The 2D (R-Z) distribution of N2H+, however, is different among the full-network model and no-sink model. The column density of N2H+ in the no-sink model depends sensitively on the desorption rate of CO and N2 and the cosmic-ray flux. We also found that N2H+ abundance can peak at the temperature slightly below the CO sublimation, even if the desorption energies of CO and N2 are the same