pinecone/core-2020-05-10-deduplication huggingface dataset:
Statistical properties of subgroups of free groups

International audienceThe usual way to investigate the statistical properties of finitely generated subgroups of free groups, and of finite presentations of groups, is based on the so-called word-based distribution: subgroups are generated (finite presentations are determined) by randomly chosen k-tuples of reduced words, whose maximal length is allowed to tend to infinity. In this paper we adopt a different, though equally natural point of view: we investigate the statistical properties of the same objects, but with respect to the so-called graph-based distribution, recently introduced by Bassino, Nicaud and Weil. Here, subgroups (and finite presentations) are determined by randomly chosen Stallings graphs whose number of vertices tends to infinity. Our results show that these two distributions behave quite differently from each other, shedding a new light on which properties of finitely generated subgroups can be considered frequent or rare. For example, we show that malnormal subgroups of a free group are negligible in the graph-based distribution, while they are exponentially generic in the word-based distribution. Quite surprisingly, a random finite presentation generically presents the trivial group in this new distribution, while in the classical one it is known to generically present an infinite hyperbolic group
Hemodynamic-informed parcellation of fMRI data in a Joint Detection Estimation framework

International audienceIdentifying brain hemodynamics in event-related functional MRI (fMRI) data is a crucial issue to disentangle the vascular response from the neuronal activity in the BOLD signal. This question is usually addressed by estimating the so-called Hemodynamic Response Function (HRF). Voxelwise or region-/parcelwise inference schemes have been proposed to achieve this goal but so far all known contributions commit to pre-specified spatial supports for the hemodynamic territories by defining these supports either as individual voxels or a priori fixed brain parcels. In this paper, we introduce a Joint Parcellation-Detection-Estimation (JPDE) procedure that incorporates an adaptive parcel identification step based upon local hemodynamic properties. Efficient inference of both evoked activity, HRF shapes and supports is then achieved using variational approximations. Validation on synthetic and real fMRI data demonstrate the JPDE performance over standard detection estimation schemes and suggest it as a new brain exploration tool
Evolution of deformation and recrystallization textures in high-purity Ni and the Ni-5 at. pct W alloy

An attempt has been made to study the evolution of texture in high-purity Ni and Ni-5 at. pct W alloy prepared by the powder metallurgy route followed by heavy cold rolling (∼95 pct deformation) and recrystallization. The deformation textures of the two materials are of typical pure metal or Cu-type texture. Cube-oriented ({001} {100}) regions are present in the deformed state as long thin bands, elongated in the rolling direction (RD). These bands are characterized by a high orientation gradient inside, which is a result of the rotation of the cube-oriented cells around the RD toward the RD-rotated cube ({013} {100}). Low-temperature annealing produces a weak cube texture along with the {013} {100} component, with the latter being much stronger in high-purity Ni than in the Ni-W alloy. At higher temperatures, the cube texture is strengthened considerably in the Ni-W alloy; however, the cube volume fraction in high-purity Ni is significantly lower because of the retention of the {013} {100} component. The difference in the relative strengths of the cube, and the {013} {100} components in the two materials is evident from the beginning of recrystallization in which more {013} {100} -oriented grains than near cube grains form in high-purity Ni. The preferential nucleation of the near cube and the {013} {100} grains in these materials seems to be a result of the high orientation gradients associated with the cube bands that offer a favorable environment for early nucleation
Induction therapy with cetuximab plus docetaxel, cisplatin, and 5-fluorouracil (ETPF) in patients with resectable nonmetastatic stage III or IV squamous cell carcinoma of the oropharynx. A GERCOR phase II ECHO-07 study

International audienceInduction TPF regimen is a standard treatment option for squamous cell carcinoma (SCC) of the oropharynx. The efficacy and safety of adding cetuximab to induction TPF (ETPF) therapy was evaluated. Patients with nonmetastatic resectable stage III/IV SCC of the oropharynx were treated with weekly cetuximab followed the same day by docetaxel and cisplatin and by a continuous infusion of 5-fluorouracil on days 1-5 (every 3 weeks, 3 cycles). The primary endpoint was clinical and radiological complete response (crCR) of primary tumor at 3 months. Secondary endpoints were crCR rates, overall response, pathological CR, progression-free survival, overall survival, and safety. Forty-two patients were enrolled, and 41 received ETPF. The all nine planned cetuximab doses and the full three doses of planned chemotherapy were completed in 31 (76%) and 36 (88%) patients, respectively. Twelve (29%) patients required dose reduction. The crCR of primary tumor at the completion of therapy was observed in nine (22%) patients. ETPF was associated with a tumor objective response rate (ORR) of 58%. The most frequent grade 3–4 toxicities were as follows: nonfebrile neutropenia (39%), febrile neutropenia (19%), diarrhea (10%), and stomatitis (12%). Eighteen (44%) patients experienced acne-like skin reactions of any grade. One toxic death occurred secondary to chemotherapy-induced colitis with colonic perforation. This phase II study reports an interesting response rate for ETPF in patients with moderately advanced SCC of the oropharynx. The schedule of ETPF evaluated in this study cannot be recommended at this dosage
Large time monotonicity of solutions of reaction-diffusion equations in $R^N$

International audienceIn this paper, we consider nonnegative solutions of spatially heterogeneous Fisher-KPP type reaction-diffusion equations in the whole space. Under some assumptions on the initial conditions, including in particular the case of compactly supported initial conditions, we show that, above any arbitrary positive value, the solution is increasing in time at large times. Furthermore, in the one-dimensional case, we prove that, if the equation is homogeneous outside a bounded interval and the reaction is linear around the zero state, then the solution is time-increasing in the whole line at large times. The question of the monotonicity in time is motivated by a medical imagery issue.Dans cet article nous étudions les solutions positives d'équations de réaction diffusion dans l'espace entier. Sous certaines conditions sur la donnée initiale, nous démontrons que, au dessus d'une certaine valeur arbitrairement petite, la solution est croissante en temps pour des temps assez grands
Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins.
 : 
Key Residues of SK3 Channel for Selective Toxin Recognition

International audiencePotassium channel functions are often deciphered by using selective and potent scorpion toxins. Among these toxins, only a limited subset is capable of selectively blocking small conductance Ca(2+)-activated K(+) (SK) channels. The structural bases of this selective SK channel recognition remain unclear. In this work, we demonstrate the key role of the electric charges of two conserved arginine residues (Arg-485 and Arg-489) from the SK3 channel outer vestibule in the selective recognition by the SK3-blocking BmP05 toxin. Indeed, individually substituting these residues with histidyl or lysyl (maintaining the positive electric charge partially or fully), although decreasing BmP05 affinity, still preserved the toxin sensitivity profile of the SK3 channel (as evidenced by the lack of recognition by many other types of potassium channel-sensitive charybdotoxin). In contrast, when Arg-485 or Arg-489 of the SK3 channel was mutated to an acidic (Glu) or alcoholic (Ser) amino acid residue, the channel lost its sensitivity to BmP05 and became susceptible to the "new" blocking activity by charybdotoxin. In addition to these SK3 channel basic residues important for sensitivity, two acidic residues, Asp-492 and Asp-518, also located in the SK3 channel outer vestibule, were identified as being critical for toxin affinity. Furthermore, molecular modeling data indicate the existence of a compact SK3 channel turret conformation (like a peptide screener), where the basic rings of Arg-485 and Arg-489 are stabilized by strong ionic interactions with Asp-492 and Asp-518. In conclusion, the unique properties of Arg-485 and Arg-489 (spatial orientations and molecular interactions) in the SK3 channel account for its toxin sensitivity profile
Uncertainty quantification for functional dependent random variables

International audienceThis paper proposes a new methodology to quantify the uncertainties associated to multiple dependent functional random variables, linked to a quantity of interest, called the covariate. The proposed methodology is composed of two main steps. First, the functional random variables are decomposed on a functional basis. The decomposition basis is computed by the proposed Simultaneous Partial Least Squares algorithm which enables to decompose simultaneously all the functional variables. Second, the joint probability density function of the coefficients of the decomposition associated to the functional variables is modelled by a Gaussian mixture model. A new method to estimate the parameters of the Gaussian mixture model based on a Lasso penalization algorithm is proposed. This algorithm enables to estimate sparse covariance matrices, in order to reduce the number of model parameters to be estimated. Several criteria are proposed to assess the efficiency of the methodology. Finally, its performance is shown on an analytical example and on a nuclear reliability test case
Role of isospin in the nuclear liquid-gas phase transition

To appear in Nuclear Physics AWe study the thermodynamics of asymmetric nuclear matter using a mean field approximation with a Skyrme effective interaction, in order to establish its phase diagram and more particularly the influence of isospin on the order of the transition. A new statistical method is introduced to study the thermodynamics of a multifluid system, keeping only one density fixed the others being replaced by their intensive conjugated variables. In this ensemble phase coexistence reduces to a simple one dimensional Maxwell construction. For a fixed temperature under a critical value, a coexistence line is obtained in the plane of neutron and proton chemical potentials. Along this line the grand potential presents a discontinuous slope showing that the transition is first order except at the two ending points where it becomes second order. This result is not in contradiction with the already reported occurrence of a continuous transformation when a constant proton fraction is imposed. Indeed, the proton fraction being an order parameter in asymmetric matter, the constraint can only be fulfilled by gradual phase mixing along the first-order phase transition line leading to a continuous pressure
Seismic vulnerability assessment to slight damage based on experimental modal parameters

International audienceThe aim of this paper is to adjust behaviour models for each class of structure for vulnerability assessment by using ambient vibration. A simple model based on frequencies, mode shapes and damping, taken from ambient vibrations, allows computation of the response of the structures and comparison of inter-storey drifts with the limits found in the literature for the slight damage grade, considered here as the limit of elastic behaviour. Two complete methodologies for building fragility curves are proposed: (1) using a multi-degree of freedom system including higher modes and full seismic ground motion, (2) using a single-degree of freedom model considering the fundamental mode f0 of the structure and ground motion displacement response spectra SD(f0). These two methods were applied to the city of Grenoble, where 60 buildings were studied. Fragility curves for slight damage were derived for the various masonry and reinforced concrete classes of buildings. A site-specific earthquake scenario, taking into account local site conditions, was considered, corresponding to an ML=5.5 earthquake at a distance of 15km. The results show the benefits of using experimental models to reduce variability of the slight damage fragility curve. Moreover, by introducing the experimental modal model of the buildings, it is possible to improve seismic risk assessment at an overall scale (the city) or a local scale (the building) for the first damage grade (slight damage). This level of damage, of great interest for moderate seismic prone regions, may contribute to the seismic loss assessment
Fe(II)-Na(I)-Ca(II) cation exchange on montmorillonite in chloride medium: Evidence for preferential clay adsorption of chloride - Metal ion pairs in seawater.

International audienceFe(II)-Ca(II), Fe(II)-Na(I), and Fe(II)-Ca(II)-Na(I) exchange experiments on montmorillonite were performed in chloride background. These experiments show the possible sorption of Fe2+ and FeCl+ ion pairs in exchange site positions, a result confirmed with 77 K 57Fe Mössbauer experiments. The sorption data were modeled and the cation exchange selectivity for Fe(II) were found to be nearly equal to that of Ca(II). Vanselow selectivity coefficients, for Na-Fe2+ and Na-FeCl+ reactions, were found to be equal to 0.4 (0.5 for Ca2+) and 2.3 (2.5 for CaCl+) respectively. High affinity of montmorillonite for chloride ion pairs seems to be a common mechanism as first stated by Sposito et al., (Soil Sci. Soc. Am. J. 47, 51-56, 1983a), and should have implications e.g., on the chemistry of suspended particles in seawater. Exchange selectivity coefficients derived from this study and others were used to model experimental data on river water and seawater equilibrated particles. The agreement between simulations and experimental data is very good. The simulation shows the predominance of monovalent ion (Na+ and chloride ion pairs) sorption on clay particles in seawater. This sorption of monovalent ions leads to the dispersion of particles in seawater and to the extension of a ldquoplumerdquo of particles spreading away from river deltas, such as that of the River Amazon
Effect of the thermal gradient variation through geological time on basin modeling; a case study: The Paris basin.

Many studies investigated the thermal modeling of the Paris basin for petroleum interests during the 1970s. Most of the softwares developed by oil companies or research centers were based on the assumption of a constant thermal gradient. In order to take into consideration the variation of the thermal gradient during basin evolution, we developed the TherMO's Visual Basic 1D program. We applied our model to twenty boreholes located along a cross-section roughly running EW over 150 km in the center of the Paris basin. The numerical results were calibrated with organic matter maturity data. TherMO's simulates the amount of heat provided to the sedimentary organic matter. The heat parameter simulated shows lateral variation along the cross-section. It decreases from Rambouillet to Trou Aux Loups boreholes (87–66 mW/m2) at about 100 km more to the east whereas the heat flux value simulated is 73 mW/m2 in St. Loup borehole. The mean thermal gradient calculated for liassic horizons at 87 My for the Rambouillet well is 50.4 °C/km. This value is similar to previously published results. By integrating the calculation of the thermal gradients and conductivities related to the burial of each stratigraphic sequence, our approach points out variations in the thermal regimes the sedimentary organic matter (SOM) has been subjected to through geological time
Synthesis of Ni-poor NiO nanoparticles for p-DSSC applications

International audienceTo improve the performances of p-Dye Sensitized Solar Cell (p-DSSC) for the future, the synthesis of modified p-type nickel oxide semiconductor, commonly used as photocathode in such devices, was initiated with Ni3O2(OH)4 as precursor. This specific nickel oxyhydroxide was first characterized by X-ray photo-electron spectroscopy and magnetic susceptibility measurements. Then its thermal decomposition was thoroughly studied in order to control the particles size of the as-prepared NiO nanopowders. Low temperature decomposition in air of this precursor allows the formation of Ni1-xO nanoparticles with a large amount of Ni vacancies and specific surface areas up to 250 m2.g-1. Its ammonolysis at 250°C leads to nanostructured N-doped NiO (NiO:N) materials
Liquid-phase and multiphase hydrodehalogenation of halobenzenes over Pd/C: Reaction selectivity and inhibition/promotion effects by the quaternary sa

Hydrodehalogenation of iodo-, bromo-, and chlorobenzene on 5% Pd/C is studied in an ethanolic base solution and in the aqueous base–isooctane system at 50 ◦C and atmospheric pressure of hydrogen. Rates and selectivity of competitive and separate reactions of different halides and the effects due to the quaternary ammonium salt, Aliquat 336, are discussed. The reactivity of halides follows the order PhCl ≈ PhBr > PhI in the biphasic system. Aliquat 336 promotes hydrodechlorination, but inhibits hydrodebromination and hydrodeiodination.\ud
The rate inhibition in the reaction of PhI is connected to formation of the iodide-substituted ammonium salt, which holds inside Pd/C and reinforces poisoning by I−, while the presence of the excess of Aliquat 336 prevents inhibition. In competitive experiments, the phenyl halides react selectively one after another according to the order of their adsorption on Pd: PhI, PhBr, PhCl, where hydrodechlorination and hydrodebromination are slowed down by the iodide anion formed in hydrodeiodination
Evidence of a bacterial carbonate coating on plaster samples subjected to the Calcite Bioconcept biomineralization technique

International audienceDegradation of historical buildings is mainly due to the intrusion of water which is the main vector of pollutants. Different types of surface treatment have been proposed to avoid or limit this effect. One alternative to chemical treatments is the use of the carbonatogenesis property of some bacteria. This bacterial production has been evidenced on concrete and on limestone samples in an aqueous environment. However, the carbonate production was measured indirectly and the experimental protocol was far from real conditions of use. In this paper, with the same protocol as an industrial one, and using a surface selective investigation method, grazing incidence X-ray diffraction, we show the structural and morphological evolution of the carbonate coating produced on model plaster samples. This substrate was chosen in order to unambiguously detect the bacterial carbonate production
Formation of graphene oxide nano-disks by electrochemical oxidation of HOPG

When HOPG (highly oriented pyrolytic graphite) was electrochemically oxidized in alkali
	solution, STM observation showed that graphite oxide with homo-sized disks 15 nm in diameter and
	0.5 nm in thickness was formed dispersively on the HOPG surface. With an increase in the anodic
	charge, the number of the disks enhanced, and covered finally the HOPG surface without overlap at the
	maximum coverage,70%. The projected area of the disks was proportional to the anodic charge when
	the charge was small. The disks were hydrophilic. The double layer capacitance of the oxidized HOPG
	increased slightly with the anodic charge, implying that the disks should be an electrical insulator. The
	fully disk-coated HOPG did not block the diffusion-controlled current of the redox species. The layer of
	the disks must be porous for ions or solutions. The formation of the uniform size may be ascribed to
	the difference between the density of graphite oxide and that of the basal plane of graphite. The
	formation of nano-disks and their properties are inconsistent with such an image of intercalation that
	ions are inserted into layers of graphenes of HOPG
Is there an association between women's consultations with a massage therapist and health-related quality of life? Analyses of 1800 women aged 56-61 years.

BACKGROUND: The use of complementary and alternative medicine (CAM) is commonplace in Australia with massage being a popular CAM modality. METHODS: This is a sub-study from the Australian Longitudinal Study on Women's Health (ALSWH). A total of 2120 mid-age (56-61 year old) women who consulted a CAM practitioner were invited to participate in this study. The Short-Form (SF-36) questionnaire was used to measure women's health-related quality of life. RESULTS: A total of 1800 women returned the questionnaire generating a response rate of 85.0%. Overall, 912 (50.7%) women visited a massage therapist in the previous 12 months. Women with lower quality of life scores in terms of bodily pain (p = 0.012) and/or emotional health (p = 0.029) were more likely to consult a massage therapist than those with higher scores. CONCLUSION: The implications of these associations are important for informing healthcare providers in providing effective and coordinated care for patients with pain and mood symptoms
A Self-Organized ECM-Mimetic Model Based on an Amphiphilic Multiblock Silk-Elastin-Like co-Recombinamer with a Concomitant Dual Physical Gelation Process

Although significant progress has been made in the area of injectable hydrogels for biomedical applications and model cell niches, further improvements are still needed, especially in terms of mechanical performance, stability, and biomimicry of the native fibrillar architecture found in the extracellular matrix (ECM). This work focuses on the design and production of a silk-elastin-based injectable multiblock corecombinamer that spontaneously forms a stable physical nanofibrillar hydrogel under physiological conditions. That differs from previously reported silk-elastin-like polymers on a major content and predominance of the elastin-like part, as well as a more complex structure and behavior of such a part of the molecule, which is aimed to obtain well-defined hydrogels. Rheological and DSC experiments showed that this system displays a coordinated and concomitant dual gelation mechanism. In a first stage, a rapid, thermally driven gelation of the corecombinamer solution takes place once the system reaches body temperature due to the thermal responsiveness of the elastin-like (EL) parts and the amphiphilic multiblock design of the corecombinamer. A bridged micellar structure is the dominant microscopic feature of this stage, as demonstrated by AFM and TEM. Completion of the initial stage triggers the second, which is comprised of a stabilization, reinforcement, and microstructuring of the gel. FTIR analysis shows that these events involve the formation of β-sheets around the silk motifs. The emergence of such β-sheet structures leads to the spontaneous self-organization of the gel into the final fibrous structure. Despite the absence of biological cues, here we set the basis of the minimal structure that is able to display such a set of physical properties and undergo microscopic transformation from a solution to a fibrous hydrogel. The results point to the potential of this system as a basis for the development of injectable fibrillar biomaterial platforms toward a fully functional, biomimetic, artificial extracellular matrix, and cell niches.Este trabajo forma parte de Proyectos de Investigación financiados por la Comisión Europea a través del Fondo Europeo de Desarrollo Regional (ERDF), por el del MINECO (MAT2013-41723-R, MAT2013- 42473-R, PRI-PIBAR-2011-1403 y MAT2012-38043), la Junta de Castilla y León (VA049A11, VA152A12 y VA155A12) y el Instituto de Salud Carlos III bajo el Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León