pinecone/core-2020-05-10-deduplication huggingface dataset:
Effectiveness of telaprevir or boceprevir in treatment-experienced patients with HCV genotype 1 infection and cirrhosis.
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Triple therapy in HCV genotype 1 cirrhotics

International audienceBACKGROUND & AIMS: We investigated the effectiveness of the protease inhibitors peginterferon and ribavirin in treatment-experienced patients with hepatitis C virus (HCV) genotype 1 infection and cirrhosis. METHODS: In the Compassionate Use of Protease Inhibitors in Viral C Cirrhosis study, 511 patients with HCV genotype 1 infection and compensated cirrhosis who did not respond to a prior course of peginterferon and ribavirin (44.3% relapsers or patients with viral breakthrough, 44.8% partial responders, and 8.0% null responders) were given either telaprevir (n = 299) or boceprevir (n = 212) for 48 weeks. We assessed percentages of patients with sustained viral responses 12 weeks after therapy and safety. This observational study did not allow for direct comparison of the 2 regimens. RESULTS: Among patients given telaprevir, 74.2% of relapsers, 40.0% of partial responders, and 19.4% of null responders achieved SVR12. Among those given boceprevir, 53.9% of relapsers, 38.3% of partial responders, and none of the null responders achieved SVR12. In multivariate analysis, factors associated with SVR12 included prior response to treatment response, no lead-in phase, HCV subtype 1b (vs 1a), and baseline platelet count greater than 100,000/mm(3). Severe adverse events occurred in 49.9% of cases, including liver decompensation, severe infections in 10.4%, and death in 2.2%. In multivariate analysis, baseline serum albumin level less than 35 g/L and baseline platelet counts of 100,000/mm(3) or less predicted severe side effects or death. CONCLUSIONS: Relatively high percentages of real-life, treatment-experienced patients with HCV genotype 1 infection and cirrhosis respond to the combination of peginterferon and ribavirin with telaprevir or boceprevir. However, side effects are frequent and often severe. Baseline levels of albumin and platelet counts can be used to guide treatment decisions. ClinicalTrials.gov number: NCT01514890
Mignon: A Fast Decentralized Content Consumption Estimation in Large-Scale Distributed Systems

International audienceAlthough many fully decentralized content distribution systems have been proposed, they often lack key capabilities that make them difficult to deploy and use in practice. In this paper, we look at the particular problem of content consumption prediction, a crucial mechanism in many such systems. We propose a novel, fully decentralized protocol that uses the tags attached by users to on-line content, and exploits the properties of self-organizing kNN overlays to rapidly estimate the potential of a particular content without explicit aggregation
New insights into pb5, the receptor binding protein of bacteriophage T5, and its interaction with its Escherichia coli receptor FhuA

International audienceThe majority of bacterial viruses are bacteriophages bearing a tail that serves to recognise the bacterial surface and deliver the genome into the host cell. Infection is initiated by the irreversible interaction between the viral receptor binding protein (RBP) and a receptor at the surface of the bacterium. This interaction results ultimately in the phage DNA release in the host cytoplasm. Phage T5 infects Escher-ichia coli after binding of its RBP pb5 to the outer membrane ferrichrome transporter FhuA. Here, we have studied the complex formed by pb5 and FhuA by a variety of biophysical and biochemical techniques. We show that unlike RBPs of known structures, pb5 probably folds as a unique domain fulfilling both functions of binding to the host receptor and interaction with the rest of the phage. Pb5 likely binds to the domain occluding the b-barrel of FhuA as well as to external loops of the barrel. Furthermore, upon binding to FhuA, pb5 undergoes conformational changes, at the secondary and tertiary structure level that would be the key to the transmission of the signal through the tail to the capsid, triggering DNA release. This is the first structural information regarding the binding of a RBP to a proteic receptor. Ó 2012 Elsevier Masson SAS. All rights reserved
Governing Energy Consumption in Hadoop through CPU Frequency Scaling: an Analysis

International audienceWith increasingly inexpensive storage and growing processing power, the cloud has rapidly become the environment of choice to store and analyze data for a variety of applications. Most large-scale data computations in the cloud heavily rely on the MapReduce paradigm and on its Hadoop implementation. Nevertheless, this exponential growth in popularity has significantly impacted power consumption in cloud infrastructures. In this paper, we focus on MapReduce processing and we investigate the impact of dynamically scaling the frequency of compute nodes on the performance and energy consumption of a Hadoop cluster. To this end, a series of experiments are conducted to explore the implications of Dynamic Voltage and Frequency Scaling (DVFS) settings on power consumption in Hadoop clusters. By enabling various existing DVFS governors (i.e., performance, powersave, ondemand, conservative and userspace) in a Hadoop cluster, we observe significant variation in performance and power consumption across different applications: the different DVFS settings are only sub-optimal for several representative MapReduce applications. Furthermore, our results reveal that the current CPU governors do not exactly reflect their design goal and may even become ineffective to manage the power consumption in Hadoop clusters. This study aims at providing a clearer understanding of the interplay between performance and power management in Hadoop clusters and therefore offers useful insight into designing power-aware techniques for Hadoop systems
Ion track grafting: A way of producing low-cost and highly proton conductive membranes for fuel cell applications

International audienceKeywords: Ion track grafting Radiografting Swift heavy ions Proton conductivity Polymer electrolyte membrane Proton exchange membrane fuel cell a b s t r a c t Proton conductive individual channels through a poly(vinyl di-fluoride) PVDF matrix have been designed using the ion track grafting technique. The styrene molecules were radiografted and further sulfonated leading to sulfonated polystyrene (PSSA) domains within PVDF. The grafting process all along the cylindrical ion tracks creates after functionalisation privileged paths perpendicular to the membrane plane for proton conduction from the anode to the cathode when used in fuel cells. Such ion track grafted PVDF-g-PSSA membranes have low gas permeation properties against H 2 and O 2. A degree of grafting (Y w) of 140% was chosen to ensure a perfect coverage of PSSA onto PVDF-g-PSSA surface minimizing interfacial ohmic losses with the active layers of the Membrane Electrolyte Assembly (MEA). A three-day fuel cell test has been performed feeding the cell with pure H 2 and O 2 , at the anode and cathode side respectively. Temperature has been progressively increased from 50 to 80 • C. Polarisation curves and Elec-trochemical Impedance Spectroscopy (EIS) at different current densities were used to evaluate the MEA performance. From these last measurements, it has been possible to determine the resistance of the MEA during the fuel cell tests and, thus the membrane conductivity. The proton conductivities of such membranes estimated during fuel cell tests range from 50 mS cm −1 to 80 mS cm −1 depending on the operating conditions. These values are close to that of perfluorosulfonated membrane such as Nafion ® in similar conditions
Engineered inorganic core/shell nanoparticles

International audienceIt has been for a long time recognized that nanoparticles are of great scientific interest as they are effectively a bridge between bulk materials and atomic structures. At first, size effects occurring in single elements have been studied. More recently, progress in chemical and physical synthesis routes permitted the preparation of more complex structures. Such structures take advantages of new adjustable parameters including stoichiometry, chemical ordering, shape and segregation opening new fields with tailored materials for biology, mechanics, optics magnetism, chemistry catalysis, solar cells and microelectronics. Among them, core/shell structures are a particular class of nanoparticles made with an inorganic core and one or several inorganic shell layer(s). In earlier work, the shell was merely used as a protective coating for the core. More recently, it has been shown that it is possible to tune the physical properties in a larger range than that of each material taken separately. The goal of the present review is to discuss the basic properties of the different types of core/shell nanoparticles including a large variety of heterostructures. We restrict ourselves on all inorganic (on inorganic/inorganic) core/shell structures. In the light of recent developments, the applications of inorganic core/shell particles are found in many fields including biology, chemistry, physics and engineering. In addition to a representative overview of the properties, general concepts based on solid state physics are considered for material selection and for identifying criteria linking the core/shell structure and its resulting properties. Chemical and physical routes for the synthesis and specific methods for the study of core/shell nanoparticle are briefly discussed
Stress and expression of cyclooxygenases (cox1, cox2a, cox2b) and intestinal eicosanoids, in Atlantic salmon, Salmo salar.

Prostaglandin H synthetases (cyclooxygenases) catalyze the initial reactions leading to prostanoids in animals. They form interesting links between diet and fish physiology as the type and nature of eicosanoids are affected by dietary lipid sources. Their expression is likely to be affected by tissues and environmental conditions leading to altered amount and ratio of eicosanoids. These mechanisms are, however, poorly understood in fish. In the present study, Atlantic salmon Salmo salar L. (1,000 g, 10°C, seawater) were subjected to acute chasing stress. Liver, kidney, spleen, gill, muscle, midgut and hindgut were extracted before and 1 h post-stress and analyzed for mRNA expression of cox1, cox2a and cox2b. Intestinal samples were further sampled over 24 h for both cox expression and analysis of 15 eicosanoids and isoprostanes of the n-3 and n-6 series. Results show a highly variable but consecutively expression of cox1, cox2a and cox2b in most of the tissues analyzed. Low levels were only found for cox2a in liver and cox2b in liver and kidney. The study reveals the general trend that cox1 is about 10 times the level of cox2b, which again is about 10 times the level of cox2a. Cox2b shows the highest level of expression in the gills indicating a possible higher requirement for this protein in gills. Imposing stress to the fish induces a temporal increase in the expression of cox2a in the midgut, while the gene expression of the other genes is not affected in any of the tissues analyzed. There is, however, a general tendency to increased expression of both cox2 genes that merits further studies. Stress had a profound effect on the intestinal eicosanoid content which showed a general decrease in midgut sections after stress that persisted for at least 24 h
Pharmacokinetics and pharmacodynamics of tacrolimus in liver transplant recipients: inside the white blood cells

International audienceObjectivesDespite improvements in patient management and extensive use of therapeutic drug monitoring (TDM), the rate of acute cellular rejection (ACR) remains high in patients treated with tacrolimus (TAC). Moreover, some patients experienced ACR while their whole-blood (WB) concentrations were maintained within the therapeutic range meaning that TDM in WB misrepresents the drug effect. Thus, monitoring TAC directly inside of its effect compartment (intracellular concentrations) or monitoring directly the inhibitory effect on the target protein (calcineurin activity) could be more relevant. The aim of the present study was to explore, in 10 de novo liver transplant recipients, the relationship between TAC whole-blood concentrations, TAC intracellular concentrations and TAC-induced intracellular calcineurin inhibition at day 1 and day 7 after treatment initiation.Design and methodsProspective monocentric observational pharmacokinetic (WB and intracellular concentrations)–pharmacodynamic (calcineurin activity) study.ResultsFull intracellular TAC pharmacokinetic as well as calcineurin activity steady-state profiles is presented in the study. The main result of this study is the lack of relationship between TAC pharmacokinetics (WB and leukocytes) and calcineurin activity in leukocytes at day 1 and day 7 after the graft implantation.ConclusionsDrug monitoring of TAC intracellular concentrations and determination of the calcineurin activity are among future potential biomarkers of acute rejection in transplant recipients. A better knowledge of the relationship between TAC whole blood and intracellular concentrations and calcineurin activity appears necessary before planning clinical trials to evaluate their potential interest as predictive biomarkers
Dynamic voltage scaling under EDF revisited

The original publication is available at www.springerlink.comInternational audienceBasic algorithms have been proposed in the field of low-power (Yao, F., et al. in Proceedings of lEEE annual foundations of computer science, pp. 374–382, 1995) which compute the minimum energy-schedule for a set of non-recurrent tasks (or jobs) scheduled under EDF on a dynamically variable voltage processor. In this study, we propose improvements upon existing algorithms with lower average and worst-case complexities. They are based on a new EDF feasibility test that helps to identify the “critical intervals”. The complexity of this feasibility test depends on structural characteristics of the set of jobs. More precisely, it depends on how tasks are included one in the other. The first step of the algorithm is to construct the Hasse diagram of the set of tasks where the partial order is defined by the inclusion relation on the tasks. Then, the algorithm constructs the shortest path in a geometrical representation at each level of the Hasse diagram. The optimal processor speed is chosen according to the maximal slope of each path
A new method for indirect mass measurements using the integral charge asymmetry at the LHC

International audienceProcesses producing a charged final state at the LHC most often have a positive or null integral charge asymmetry. We propose a novel method for an indirect measurement of the mass of these final states based upon the process integral charge asymmetry. We present this method in three stages. Firstly, the theoretical prediction of the integral charge asymmetry and its related uncertainties are studied through parton level cross sections calculations. Secondly, the experimental extraction of the integral charge asymmetry of a given signal, in the presence of some background, is performed using particle level simulations. Process dependent templates enable to convert the measured integral charge asymmetry into an estimated mass of the charged final state. Thirdly, a combination of the experimental and the theoretical uncertainties determines the full uncertainty of the indirect mass measurement. This new method applies to all charged current processes at the LHC. In this article, we demonstrate its effectiveness at extracting the mass of the W boson, as a first step, and the sum of the masses of a chargino and a neutralino in case these supersymmetric particles are produced by pair, as a second step
A flash flood hazard assessment in dry valleys (northern France) by cellular automata modelling

International audienceThis paper presents an application of a cellular automaton-based runoff model (RUICELLS) to a series of small dry valleys in the Seine-Maritime department, northern France, to better assess their susceptibility to flash flood. These muddy floods shortly follow high rainfall (50–100 mm in less than 6 h) and occur in very small areas (\20 km 2). A surge generally rushes down through the main valley just a few minutes after rains have peaked. Previous events (n = 69, in the period 1983–2005) have occasionally threatened human lives and have caused significant damage to property and infrastructure. Nonetheless , given the variation among the valleys and the infrequency of events, these floods have not been numerous enough to permit a statistical analysis. Instead, we numerically simulate the possible future flash floods using RUICELLS, a cellular automaton model driven by a set of three deterministic hydrological rules. Simulations have been conducted for 148 basins, each subject to 16 different rainfall scenarios (2.368 simulations in total) to (1) estimate the peak flow discharges (Q), the specific peak flows (Q s), and the lag times (T) of the flash floods and (2) detect the critical rainfall intensities that would trigger warnings and increased vigilance. Our simulations indicate that the number of basins susceptible to flash flooding greatly increases with the higher rainfall intensity, the distribution of sensitive crops (sugar beet, corn, maize, and flax) and the basin morphology. Several small basins could also induce by convergence a bigger flood in the downstream humid valleys. The location of the highest simulated discharges is aligned with observed events, and this comparison provides an evaluation of the modelling performance and of the credibility of the results
Interoperable atlases of the human brain

International audienceThe last two decades have seen an unprecedented development of human brain mapping approaches at various spatial and temporal scales. Together, these have provided a large fundus of information on many different as-pects of the human brain including micro-and macrostructural segregation, regional specialization of function, connectivity, and temporal dynamics. Atlases are central in order to integrate such diverse information in a topo-graphically meaningful way. It is noteworthy, that the brain mapping field has been developed along several major lines such as structure vs. function, postmortem vs. in vivo, individual features of the brain vs. population-based aspects, or slow vs. fast dynamics. In order to understand human brain organization, however, it seems inevitable that these different lines are integrated and combined into a multimodal human brain model. To this aim, we held a workshop to determine the constraints of a multi-modal human brain model that are needed to enable (i) an integration of different spatial and temporal scales and data modalities into a common reference system, and (ii) efficient data exchange and analysis. As detailed in this report, to arrive at fully interoperable atlases of the human brain will still require much work at the frontiers of data acquisition, analysis, and represen-tation. Among them, the latter may provide the most challenging task, in particular when it comes to representing features of vastly different scales of space, time and abstraction. The potential benefits of such endeavor, however, clearly outweigh the problems, as only such kind of multi-modal human brain atlas may provide a starting point from which the complex relationships between structure, function, and connectivity may be explored
A new method to predict meteor showers. I. Description of the model

The original publication is available in Astronomy & Astrophysics at www.aanda.org.International audienceObservations of meteor showers allow us to constrain several cometary parameter and to retrieve useful parameters on cometary dust grains, for instance the dust size distribution index s. In this first paper, we describe a new model to compute the time and level of a meteor shower whose parent body is a known periodic comet. The aim of our work was to use all the available knowledge on cometary dust to avoid most of the "a priori" hypotheses of previous meteoroid stream models. The ejection velocity is based on a hydrodynamic model. Because of the large amount of particles released by the comet, it is impossible to compute the orbits of all of them. Instead, we link each computed particle with the real number of meteoroids ejected in the same conditions, through a "dirty snowball" cometary model calibrated with the [A f ρ] parameter. We used a massive numerical integration for all the particles without hypotheses about size distribution. The time of maximum is evaluated from the position of the nodes of impacting meteoroids. The model allows us to compute ephemerides of meteors showers and the spatial density of meteors streams, from which a ZHR can be estimated. At the end a fit of our predictions with observations allows us to compute the dust size distribution index. We used 2002 and 2003 leonid meteor showers to illustrate our method. The application of our model to the Leonid meteor shower from 1833 to 2100 is given in Paper II
Dynamic aspects of cerium dioxide sintering: HT-ESEM study of grain growth and pore elimination

International audienceSintering of CeO2 is studied in situ by high temperature scanning environmental microscopy (HT-ESEM) at T = 1400 °C. The morphological modifications of a single grains population are recorded for 6 h. Kinetic parameters are extracted from image series. The local grain growth determined from the single population studied in situ is compared to the general grain growth obtained by classical ex situ technique. Using HT-ESEM for sintering study is validated. The grain boundary velocities range between 0 and 5 μm h−1, with a mean value of about 1 μm h−1. The migration of the intragranular surface pores is described. Their velocities range between 0.4 and 1.2 μm h−1 and depend on pore diameters: the smaller the pore, the faster the pore velocity. The time required to fill a pore that arises at the sample surface is determined as a function of pore diameter. The time for pore elimination dependence with the pore diameters is also established
Holocene land-use evolution and associated soil erosion in the French Prealps inferred from Lake Paladru sediments and archaeological evidences

International audienceA source-to-sink multi-proxy approach has been performed within Lake Paladru (492 m a.s.l., French Prealps) catchment and a six-meter long sediment sequence retrieved from the central lacustrine basin. The combination of minerogenic signal, specific organic markers of autochthonous and allochthonous supply and archaeological data allows the reconstruction of a continuous record of past human disturbances. Over the last 10000 years, the lacustrine sedimentation was dominated by autochthonous carbonates and the watershed was mostly forest-covered. However, seven phases of higher accumulation rate, soil erosion, algal productivity and landscape disturbances have been identified and dated from 8400-7900, 6000-4800, 4500-3200, 2700-2050 cal BP as well as AD 350-850, AD 1250-1850 and after AD 1970. Before 5200 cal BP, soil erosion is interpreted as resulting from climatic deterioration phases toward cooler and wetter conditions. During the Mid-Late Holocene period, erosion fluxes and landscape disturbances are always associated with prehistorical and historical human activities and amplified by climatic oscillations. Such changes in human land-used led to increasing minerogenic supply and nutrients loading that affected lacustrine trophic levels, especially during the last 1600 years. In addition, organic and molecular markers document previously unknown human settlements around Lake Paladru during the Bronze and the Iron Ages