pinecone/core-2020-05-10-deduplication huggingface dataset:
Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response.

Type I interferons (IFN-I) are essential antiviral cytokines produced upon microbial infection. IFN-I elicits this activity through the upregulation of hundreds of IFN-I-stimulated genes (ISGs). The full breadth of ISG induction demands activation of a number of cellular factors including the IκB kinase epsilon (IKKε). However, the mechanism of IKKε activation upon IFN receptor signaling has remained elusive. Here we show that TRIM6, a member of the E3-ubiquitin ligase tripartite motif (TRIM) family of proteins, interacted with IKKε and promoted induction of IKKε-dependent ISGs. TRIM6 and the E2-ubiquitin conjugase UbE2K cooperated in the synthesis of unanchored K48-linked polyubiquitin chains, which activated IKKε for subsequent STAT1 phosphorylation. Our work attributes a previously unrecognized activating role of K48-linked unanchored polyubiquitin chains in kinase activation and identifies the UbE2K-TRIM6-ubiquitin axis as critical for IFN signaling and antiviral response
Micro-abrasion resistance of thermochemically treated steels in aqueous solutions : mechanisms, maps, materials selection

The area of micro-abrasion is an interesting and relatively recent area in tribo-testing methodologies, where small particles of less than
10 mm are employed between interacting surfaces. It is topical for a number of reasons; its direct relation to the mechanisms of the wear
process in bio-tribological applications, ease in conducting tests and the good repeatability of the test results. It has widespread
applications in conditions used in the space and offshore industries to bio-engineering for artificial joints and implants.
There have been many recent studies on the micro-abrasion performance of materials, ranging from work basic metals to nanostructured
coatings. However, no significant work is reported on the micro-abrasion resistance of thermochemically treated steels.
Hence, this paper looks at the performance of two thermochemically treated steels, Tenifer bath nitride stainless steel (T-SS) and
vanadized carbon steel (V-CS) in such conditions with reference to the stainless steel (SS) by varying the applied load and sliding
distance.
The results indicated that T-SS demonstrates exceptionally poor resistance to micro-abrasion. It was observed that the heat treatment
process and properties of the hardened layer (hardness and thickness) are extremely important in determining the micro-abrasion
resistance of such steels. Finally, the results were used to develop micro-abrasion mechanism and wastage maps, which can be used to
optimize the surface treated materials for micro-abrasion resistance.Material Science Department of Faculty of Mechanical Engineering
Naval Architecture, University of Zagreb, Croatia
Color texture discrimination using the principal geodesic distance on a multivariate generalized Gaussian manifold

We present a new texture discrimination method for textured color images in the wavelet domain. In each wavelet subband, the correlation between the color bands is modeled by a multivariate generalized Gaussian distribution with fixed shape parameter (Gaussian, Laplacian). On the corresponding Riemannian manifold, the shape of texture clusters is characterized by means of principal geodesic analysis, specifically by the principal geodesic along which the cluster exhibits its largest variance. Then, the similarity of a texture to a class is defined in terms of the Rao geodesic distance on the manifold from the texture's distribution to its projection on the principal geodesic of that class. This similarity measure is used in a classification scheme, referred to as principal geodesic classification (PGC). It is shown to perform significantly better than several other classifiers
Direct photon production in Pb–Pb collisions at √sNN=2.76TeV

Direct photon production at mid-rapidity in Pb–Pb collisions at √sNN=2.76TeVwas studied in the transverse momentum range 0.9 <pT<14GeV/c. Photons were detected with the highly segmented electromagnetic calorimeter PHOS and via conversions in the ALICE detector material with the e+e−pair reconstructed in the central tracking system. The results of the two methods were combined and direct photon spectra were measured for the 0–20%, 20–40%, and 40–80% centrality classes. For all three classes, agreement was found with perturbative QCD calculations for pT5GeV/c. Direct photon spectra down to pT≈1GeV/ccould be extracted for the 20–40% and 0–20% centrality classes. The significance of the direct photon signal for 0.9<pT<2.1GeV/cis 2.6σfor the 0–20% class. The spectrum in this pTrange and centrality class can be described by an exponential with an inverse slope parameter of (297±12stat±41syst)MeV. State-of-the-art models for photon production in heavy-ion collisions agree with the data within uncertainties
Search for microscopic black holes in pp collisions at √ s = 7 TeV

Journal of High Energy Physics 2012.4 (2012): 061 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMA search for microscopic black holes in pp collisions at a center-of-mass energy of 7TeV is presented. The data sample corresponds to an integrated luminosity of 4.7 fb1 recorded by the CMS experiment at the LHC in 2011. Events with large total transverse energy have been analyzed for the presence of multiple energetic jets, leptons, and photons, which are typical signals of evaporating semiclassical and quantum black holes, and string balls. Agreement with the expected standard model backgrounds, which are dominated by QCD multijet production, has been observed for various combined multiplicities of jets and other reconstructed objects in the final state. Model-independent limits are set on new physics processes producing high-multiplicity, energetic final states. In addition, new model-specific indicative limits are set excluding semiclassical and quantum black holes with masses below 3.8 to 5.3TeV and string balls with masses below 4.6 to 4.8TeV . The analysis has a substantially increased sensitivity compared to previous searche
Measurement of the differential cross-sections of inclusive, prompt and non-prompt J/psi production in proton-proton collisions at sqrt(s) = 7 TeV

The inclusive J/psi production cross-section and fraction of J/psi mesons produced in B-hadron decays are measured in proton proton collisions at root s = 7 TeV with the ATLAS detector at the LHC, as a function of the transverse momentum and rapidity of the J/psi, using 2.3 pb(-1) of integrated luminosity. The cross-section is measured from a minimum P(T) of 1 GeV to a maximum of 70 GeV and for rapidities within vertical bar y vertical bar < 2.4 giving the widest reach of any measurement of J/psi production to date. The differential production cross-sections of prompt and non-prompt J/psi are separately determined and are compared to Colour Singlet NNLO*, Colour Evaporation Model, and FONLL predictions
Gauss Legendre - Gauss Jacobi quadrature rules over a Tetrahedral region

This paper presents a Gaussian quadrature method for the evaluation of the triple integral I = â«â«â«/T f (x, y, z) dxdydz, where f (x, y, z) is an analytic function in x, y, z and T refers to the standard tetrahedral region:(x, y, z) | 0 â¤ x, y, z â¤1, x + y + z â¤1 in three space (x, y, z). Mathematical transformation from (x, y, z) space to (u, v, w) space maps the standard tetrahedron T in (x, y, z) space to a standard 1-cube: (u,v,w) / 0 â¤ u, v, w â¤1 in (u, v, w) space. Then we use the product of Gauss-Legendre and Gauss-Jacobi weight coefficients and abscissas to arrive at an efficient quadrature rule over the standard tetrahedral region T. We have then demonstrated the application of the derived quadrature rules by considering the evaluation of some typical triple integrals over the region T
Polymorphic phase transformation of Degussa P25 TiO2 by the chelation of diaminopyridine on TiO6 2- octahedron: Correlation of anatase to rutile phase ratio on the photocatalytic activity

A series of nitrogen-doped Degussa P25 photocatalysts were synthesized successfully by grinding and calcination method using 2,6-diaminopyridine (DAP) as a nitrogen precursor. The prepared samples were characterized by various analytical methods. The phase contents of anatase and rutile in the Degussa P25 powders have been altered by simply changing the proportion of DAP. A mechanism involving chelated DAP molecule on TiO6 2- octahedron is discussed. The enhanced activity is attributed to synergistic effect in the two phase solid material. Due to the low activation barrier, the effective inter particle electron transfer between the two polymorphs is quite efficient only when they are in close proximity with similar crystallite sizes. The transfer of electrons from the rutile phase to lattice/electron trapping sites of anatase and also to the Ti3+-Vo defect level created by the dopant favors effective charge separation and enhance the photocatalytic activity under solar illumination. Â© 2013 Elsevier B.V. Â© 2013 Elsevier B.V. All rights reserved
Near-IR imaging towards a puzzling YSO precessing jet

At present there are many studies concerning jets towards low-mass young
stellar objects, while equivalent studies towards massive or intermediate-mass
young stellar objects are scarce. In a previous study, we found highly
misaligned molecular outflows towards the infrared point source IRS. Using
near-IR data acquired with Gemini-NIRI at the JHKs-broad-bands and narrow-bands
centered at the emission lines of [FeII], H2 1-0 S(1), H2 2-1 S(1), Br-gamma,
and CO 2-0 (bh), we studied the circumstellar environment of IRS with an
angular resolution between 0.35" and 0.45". The emission in the
JHKs-broad-bands shows, with great detail, the presence of a cone-like shape
nebula extending to the north/northeast of the point source, which appears to
be attached to it by a jet-like structure. In the three bands the nebula is
resolved in a twisted-shaped feature composed by two arc-like features and a
bow shock-like structure seen mainly in the Ks-band, which strongly suggests
the presence of a precessing jet. An analysis of proper motions based on our
Gemini observations and UKIDSS data gives additional support to the precession
scenario. We are presenting one of the best resolved cone-like nebula likely
related to a precessing jet up to date. The analysis of the observed
near-infrared lines shows that the H2 is collisionally excited, and the
spatially coincidence of the [FeII] and H2 emissions in the closer arc-like
feature suggests that this region is affected by a J-shock. The second arc-like
feature presents H2 emission without [FeII] which suggests the presence of a
nondisociative C-shock or a less energetic J-shock. The H2 1-0 S(1) continuum
subtracted image, reveals several knots and filaments at a larger spatial scale
around IRS, in perfect matching with the distribution of the red and
blueshifted molecular outflows discovered in our previous work.Comment: Accepted to be published in A&A (August 3, 2016
Search for high-mass Z-gamma resonances in e+e-gamma and mu+mu-gamma
  final states in proton-proton collisions at sqrt(s) = 8 and 13 TeV

This paper describes the search for a high-mass narrow-width scalar particle
decaying into a Z boson and a photon. The analysis is performed using
proton-proton collision data recorded with the CMS detector at the LHC at
center-of-mass energies of 8 and 13 TeV, corresponding to integrated
luminosities of 19.7 and 2.7 inverse femtobarns, respectively. The Z bosons are
reconstructed from opposite-sign electron or muon pairs. No statistically
significant deviation from the standard model predictions has been found in the
200-2000 GeV mass range. Upper limits at 95% confidence level have been derived
on the product of the scalar particle production cross section and the
branching fraction of the Z decaying into electrons or muons, which range from
280 to 20 fb for resonance masses between 200 and 2000 GeV.Comment: Replaced with the published version. Added the journal reference and
  DOI. All the figures and tables can be found at
  http://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-16-021/index.htm
MiNDSTEp differential photometry of the gravitationally lensed quasars
  WFI2033-4723 and HE0047-1756: Microlensing and a new time delay

We present V and R photometry of the gravitationally lensed quasars
WFI2033-4723 and HE0047-1756. The data were taken by the MiNDSTEp collaboration
with the 1.54 m Danish telescope at the ESO La Silla observatory from 2008 to
2012. Differential photometry has been carried out using the image subtraction
method as implemented in the HOTPAnTS package, additionally using GALFIT for
quasar photometry. The quasar WFI2033-4723 showed brightness variations of
order 0.5 mag in V and R during the campaign. The two lensed components of
quasar HE0047-1756 varied by 0.2-0.3 mag within five years. We provide, for the
first time, an estimate of the time delay of component B with respect to A of
$\Delta t= 7.6\pm1.8$ days for this object. We also find evidence for a secular
evolution of the magnitude difference between components A and B in both
filters, which we explain as due to a long-duration microlensing event. Finally
we find that both quasars WFI2033-4723 and HE0047-1756 become bluer when
brighter, which is consistent with previous studies.Comment: 16 pages, 15 figures, 10 tables. Accepted for publication in A&
Predictive regularity representations in violation detection and auditory stream segregation: from conceptual to computational models.

Predictive accounts of perception have received increasing attention in the past 20 years. Detecting violations of auditory regularities, as reflected by the Mismatch Negativity (MMN) auditory event-related potential, is amongst the phenomena seamlessly fitting this approach. Largely based on the MMN literature, we propose a psychological conceptual framework called the Auditory Event Representation System (AERS), which is based on the assumption that auditory regularity violation detection and the formation of auditory perceptual objects are based on the same predictive regularity representations. Based on this notion, a computational model of auditory stream segregation, called CHAINS, has been developed. In CHAINS, the auditory sensory event representation of each incoming sound is considered for being the continuation of likely combinations of the preceding sounds in the sequence, thus providing alternative interpretations of the auditory input. Detecting repeating patterns allows predicting upcoming sound events, thus providing a test and potential support for the corresponding interpretation. Alternative interpretations continuously compete for perceptual dominance. In this paper, we briefly describe AERS and deduce some general constraints from this conceptual model. We then go on to illustrate how these constraints are computationally specified in CHAINS
Cavity ring‑up spectroscopy for dissipative and dispersive sensing in a whispering gallery mode resonator

In whispering gallery mode resonator sensing applications, the conventional way to detect a change in the parameter to be measured is by observing the steady-state transmission spectrum through the coupling waveguide. Alternatively, sensing based on cavity ring-up spectroscopy, i.e. CRUS, can be achieved transiently. In this work, we investigate CRUS using coupled mode equations and find analytical solutions with a large spectral broadening approximation of the input pulse. The relationships between the frequency detuning, coupling gap and ring-up peak height are determined and experimentally verified using an ultrahigh Q-factor silica microsphere. This work shows that distinctive dispersive and dissipative transient sensing can be realised by simply measuring the peak height of the CRUS signal, which may improve the data collection rate
Uncomfortable Truths – Teamworking under Lean in the UK.

yesThis article responds to a recent contribution to this journal. Procter and Radnor (2014) provide an account of teamworking in the UK Civil Service, specifically Her Majesty’s Revenue and Customs (HMRC), which focuses on the relationship between recently implemented lean work organisation and teams and teamworking. This intervention is prompted by criticism of the present authors’ published research into lean in the same locus (e.g. Carter et al, 2011a; 2011b; 2013a; 2013b). Procter and Radnor claim, without foundation we argue, that our work is ‘one-sided’ and that theirs delivers a ‘more nuanced’ analysis of lean in this government department - and it follows - of the lean phenomenon more generally. Our riposte critiques their article on several grounds. Firstly, it suffers from problems of logic and construction, conceptual confusion and definitional imprecision. Methodological difficulties and inconsistent evidence contribute additionally to analytical weakness. Included in our response are empirical findings on teamworking at HMRC, which challenge Procter and Radnor’s evidential basis and further reveal the shortcomings of their interpretation
System-based proteomic and metabonomic analysis of the Df(16)A(+/-) mouse identifies potential miR-185 targets and molecular pathway alterations

Deletions on chromosome 22q11.2 are a strong genetic risk factor for development of schizophrenia and cognitive dysfunction. We employed shotgun liquid chromatography-mass spectrometry (LC-MS) proteomic and metabonomic profiling approaches on prefrontal cortex (PFC) and hippocampal (HPC) tissue from Df(16)A(+/-) mice, a model of the 22q11.2 deletion syndrome. Proteomic results were compared with previous transcriptomic profiling studies of the same brain regions. The aim was to investigate how the combined effect of the 22q11.2 deletion and the corresponding miRNA dysregulation affects the cell biology at the systems level. The proteomic brain profiling analysis revealed PFC and HPC changes in various molecular pathways associated with chromatin remodelling and RNA transcription, indicative of an epigenetic component of the 22q11.2DS. Further, alterations in glycolysis/gluconeogenesis, mitochondrial function and lipid biosynthesis were identified. Metabonomic profiling substantiated the proteomic findings by identifying changes in 22q11.2 deletion syndrome (22q11.2DS)-related pathways, such as changes in ceramide phosphoethanolamines, sphingomyelin, carnitines, tyrosine derivates and panthothenic acid. The proteomic findings were confirmed using selected reaction monitoring mass spectrometry, validating decreased levels of several proteins encoded on 22q11.2, increased levels of the computationally predicted putative miR-185 targets UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT1) and kinesin heavy chain isoform 5A and alterations in the non-miR-185 targets serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, neurofilament light chain and vesicular glutamate transporter 1. Furthermore, alterations in the proteins associated with mammalian target of rapamycin signalling were detected in the PFC and with glutamatergic signalling in the hippocampus. Based on the proteomic and metabonomic findings, we were able to develop a schematic model summarizing the most prominent molecular network findings in the Df(16)A(+/-) mouse. Interestingly, the implicated pathways can be linked to one of the most consistent and strongest proteomic candidates, (OGT1), which is a predicted miR-185 target. Our results provide novel insights into system-biological mechanisms associated with the 22q11DS, which may be linked to cognitive dysfunction and an increased risk to develop schizophrenia. Further investigation of these pathways could help to identify novel drug targets for the treatment of schizophrenia.Molecular Psychiatry advance online publication, 22 March 2016; doi:10.1038/mp.2016.27
First-Line Afatinib versus Chemotherapy in Patients with Non–Small Cell Lung Cancer and Common Epidermal Growth Factor Receptor Gene Mutations and Brain Metastases

INTRODUCTION: Metastatic spread to the brain is common in patients with non-small cell lung cancer (NSCLC), but these patients are generally excluded from prospective clinical trials. The studies, phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations (LUX-Lung 3) and a randomized, open-label, phase III study of BIBW 2992 versus chemotherapy as first-line treatment for patients with stage IIIB or IV adenocarcinoma of the lung harbouring an EGFR activating mutation (LUX-Lung 6) investigated first-line afatinib versus platinum-based chemotherapy in epidermal growth factor receptor gene (EGFR) mutation-positive patients with NSCLC and included patients with brain metastases; prespecified subgroup analyses are assessed in this article. METHODS: For both LUX-Lung 3 and LUX-Lung 6, prespecified subgroup analyses of progression-free survival (PFS), overall survival, and objective response rate were undertaken in patients with asymptomatic brain metastases at baseline (n = 35 and n = 46, respectively). Post hoc analyses of clinical outcomes was undertaken in the combined data set (n = 81). RESULTS: In both studies, there was a trend toward improved PFS with afatinib versus chemotherapy in patients with brain metastases (LUX-Lung 3: 11.1 versus 5.4 months, hazard ratio [HR] = 0.54, p = 0.1378; LUX-Lung 6: 8.2 versus 4.7 months, HR = 0.47, p = 0.1060). The magnitude of PFS improvement with afatinib was similar to that observed in patients without brain metastases. In combined analysis, PFS was significantly improved with afatinib versus with chemotherapy in patients with brain metastases (8.2 versus 5.4 months; HR, 0.50; p = 0.0297). Afatinib significantly improved the objective response rate versus chemotherapy in patients with brain metastases. Safety findings were consistent with previous reports. CONCLUSIONS: These findings lend support to the clinical activity of afatinib in EGFR mutation-positive patients with NSCLC and asymptomatic brain metastases