pinecone/core-2020-05-10-deduplication huggingface dataset:
Mapping dynamical properties of cortical microcircuits using robotized TMS and EEG: Towards functional cytoarchitectonics

International audienceBrain dynamics at rest depend on the large-scale interactions between oscillating cortical microcircuits arranged into macrocolumns. Cytoarchitectonic studies have shown that the structure of those microcircuits differs between cortical regions, but very little is known about interregional differences of their intrinsic dynamics at a macro-scale in human. We developed here a new method aiming at mapping the dynamical properties of cortical microcircuits non-invasively using the coupling between robotized transcranial magnetic stimulation and elec-troencephalography. We recorded the responses evoked by the stimulation of 18 cortical targets largely covering the accessible neocortex in 22 healthy volunteers. Specific data processing methods were developed to map the local source activity of each cortical target, which showed interregional differences with very good interhemi-spheric reproducibility. Functional signatures of cortical microcircuits were further studied using spatio-temporal decomposition of local source activities in order to highlight principal brain modes. The identified brain modes revealed that cortical areas with similar intrinsic dynamical properties could be distributed either locally or not, with a spatial signature that was somewhat reminiscent of resting state networks. Our results provide the proof of concept of " functional cytoarchitectonics " , that would guide the parcellation of the human cortex using not only its cytoarchitecture but also its intrinsic responses to local perturbations. This opens new avenues for brain modelling and physiopathology readouts
Transfluthrin indoor air concentration and inhalation exposure during application of electric vaporizers

International audienceDifferent household insecticide applications via two electric vaporizers emitting transfluthrin were realized in a full-scale experimental room under controlled air exchange rate conditions. On-line high-time resolved measurements of the gas-phase concentrations of the active substance during and immediately after the spreading periods were performed with a High Sensitivity Proton-Transfer-Reaction Mass Spectrometer (HS-PTR-MS). Experimental and modelled data from the ConsExpo 4.0 software were also compared to evaluate the sources of differences. Different application scenarios were also compared. Averaged inhaled concentrations over 1h, 1week, and 5months were estimated to be 8.3, 1.8, and 1.8μg.m(-3), respectively. Corresponding margins of exposures range from 1000 to 10,000, claiming for the absence of effect. Dermal and dust ingestion pathways, although roughly estimated, seems being non-negligible. This claims for a more in-depth integrated risk assessment
Ab initio calculation of effective work functions for a TiN/HfO(2)/SiO(2)/Si transistor stack

International audienceClose Ab initio techniques are used to calculate the effective work function (Weff) of a TiN/HfO2/SiO2/Si stack representing a metal-oxide-semiconductor (MOS) transistor gate taking into account first order many body effects. The required band offsets were calculated at each interface varying its composition. Finally, the transitivity of local density approximation (LDA) calculated bulk band lineups were used and completed by many body perturbation theory (MBPT) bulk corrections for the terminating materials (Si and TiN) of the MOS stack. With these corrections the ab initio calculations predict a Weff of a TiN metal gate on HfO2 to be close to 5.0 eV
First detection of a diamagnetic cavity at comet 67P/Churyumov-Gerasimenko

International audienceContext: The Rosetta magnetometer RPC-MAG has been exploring the plasma environment of comet 67P/Churyumov-Gerasimenko since August 2014. The first months were dominated by low-frequency waves which evolved into more complex features. However, at the end of July 2015, close to perihelion, the magnetometer detected a region that did not contain any magnetic field at all.Aims: These signatures match the appearance of a diamagnetic cavity as was observed at comet 1P/Halley in 1986. The cavity here is more extended than previously predicted by models and features unusual magnetic field configurations, which need to be explainedMethods: The onboard magnetometer data were analyzed in detail and used to estimate the outgassing rate. A minimum variance analysis was used to determine boundary normals.Results. Our analysis of the data acquired by the Rosetta Plasma Consortium instrumentation confirms the existence of a diamagnetic cavity. The size is larger than predicted by simulations, however. One possible explanation are instabilities that are propagating along the cavity boundary and possibly a low magnetic pressure in the solar wind. This conclusion is supported by a change in sign of the Sun-pointing component of the magnetic field. Evidence also indicates that the cavity boundary is moving with variable velocities ranging from 230−500 m/s
TtcA a new tRNA-thioltransferase with an Fe-S cluster

International audienceTtcA catalyzes the post-transcriptional thiolation of cytosine 32 in some tRNAs. The enzyme from Es-cherichia coli was homologously overexpressed in E. coli. The purified enzyme is a dimer containing an iron–sulfur cluster and displays activity in in vitro assays. The type and properties of the cluster were investigated using a combination of UV-visible absorption , EPR and M ¨ ossbauer spectroscopy, as well as by site-directed mutagenesis. These studies demonstrated that the TtcA enzyme contains a redox-active and oxygen-sensitive [4Fe-4S] cluster, chelated by only three cysteine residues and absolutely essential for activity. TtcA is unique tRNA-thiolating enzyme using an iron–sulfur cluster for catalyzing a non-redox reaction
Circulant temporal encoding for video retrieval and temporal alignment

International audienceWe address the problem of specific video event retrieval. Given a query video of a specific event, e.g., a concert of Madonna, the goal is to retrieve other videos of the same event that temporally overlap with the query. Our approach encodes the frame descriptors of a video to jointly represent their appearance and temporal order. It exploits the properties of circulant matrices to efficiently compare the videos in the frequency domain. This offers a significant gain in complexity and accurately localizes the matching parts of videos. The descriptors can be compressed in the frequency domain with a product quantizer adapted to complex numbers. In this case, video retrieval is performed without decompressing the descriptors. We also consider the temporal alignment of a set of videos. We exploit the matching confidence and an estimate of the temporal offset computed for all pairs of videos by our retrieval approach. Our robust algorithm aligns the videos on a global timeline by maximizing the set of temporally consistent matches.  The global temporal alignment enables synchronous playback of the videos of a given scene
Construction and test of a 1×1 m2 Micromegas chamber for sampling hadron calorimetry at future lepton colliders

Equipe MicromegasSampling calorimeters can be finely segmented and used to detect showers with high spatial resolution. This imaging power can be exploited at future linear collider experiments where the measurement of jet energy by a Particle flow method requires optimal use of tracking and calorimeter information. Gaseous detectors can achieve high granularity and a hadron sampling calorimeter using Micromegas chambers as active elements is considered in this paper. Compared to traditional detectors using wires or resistive plates, Micromegas is free of space charge effects and could therefore show superior calorimetric performance. To test this concept, a prototype of 1×1 m2 equipped with 9216 readout pads of 1×1 cm2 has been built. Its technical and basic operational characteristics are reported
Flavour physics and CP violation

It is well known that the study of flavour physics and CP violation is very important to critically test the Standard Model and to look for possible signature of new physics beyond it. The observation of CP violation in kaon system in 1964 has ignited a lot of experimental and theoretical efforts to understand its origin and to look for CP violation effects in other systems besides the neutral kaons. The two B-factories BABAR and BELLE, along with other experiments, in the last decade or so made studies in flavour physics and CP violation a very interesting one. In this article we discuss the status and prospectives of the flavour physics associated with the strange, charm and bottom sectors of the Standard Model. The important results in kaon sector will be briefly discussed. Recently, mixing in the charm system has been observed, which was being pursued for quite some time without any success. The smallness of the mixing parameters in the charm system is due to the hierarchical structure of the CKM matrix. Interestingly, so far we have not found CP violation in the charm system but in the future, with more dedicated experiments at charm threshold, the situation could change. Many interesting observations have been made in the case of bottom mesons and some of them show some kind of deviations from that of the Standard Model expectations which are mainly associated with the b → s flavour changing neutral current transitions. It is long believed that the B s system could be the harbinger of new physics since it is a system in which both bottom and strange quarks are the constituents. Recently, D0 and CDF announced their result for the B s mixing which is claimed to be the first possible new physics signature in the flavour sector. We plan to touch upon all important issues pointing out both theoretical and experimental developments and future prospects in this review article
Electron acceleration by surface plasma waves in the interaction between femtosecond laser pulses and sharp-edged overdense plasmas

International audienceThe relativistic acceleration of electrons by the field of surface plasma waves created in the interaction between ultrashort high-intensity laser pulses with sharp-edged overdense plasmas has been investigated. It is shown that the initial phase of the wave experienced by the electrons play a leading part by yielding a well-defined peaked structure in the energy distribution function. This study suggests that resonant excitation of surface plasma waves could result in quasi-monokinetic energetic electron bunches. When the space charge field becomes too strong, this mechanism can evolve toward a true absorption process of the surface wave energy via an enhanced ''vacuum heating'' mechanism generalized to the case of surface plasma waves
Godunov type scheme for the linear wave equation with Coriolis source term

International audienceWe propose a method to explain the behavior of the Godunov finite volume scheme applied to the linear wave equation with Coriolis source term at low Froude number. In particular, we use the Hodge decomposition and we study the properties of the modified equation associated to the Godunov scheme. Based on the structure of the discrete kernel of the linear operator discretized by using the Godunov scheme, we clearly explain the inaccuracy of the classical Godunov scheme at low Froude number and we introduce the way to modify it to recover a good accuracy
Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease.
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IgA retrotranscytosis in celiac disease

International audienceCeliac disease (CD) is an enteropathy resulting from an abnormal immune response to gluten-derived peptides in genetically susceptible individuals. This immune response is initiated by intestinal transport of intact peptide 31-49 (p31-49) and 33-mer gliadin peptides through an unknown mechanism. We show that the transferrin receptor CD71 is responsible for apical to basal retrotranscytosis of gliadin peptides, a process during which p31-49 and 33-mer peptides are protected from degradation. In patients with active CD, CD71 is overexpressed in the intestinal epithelium and colocalizes with immunoglobulin (Ig) A. Intestinal transport of intact p31-49 and 33-mer peptides was blocked by polymeric and secretory IgA (SIgA) and by soluble CD71 receptors, pointing to a role of SIgA-gliadin complexes in this abnormal intestinal transport. This retrotranscytosis of SIgA-gliadin complexes may promote the entry of harmful gliadin peptides into the intestinal mucosa, thereby triggering an immune response and perpetuating intestinal inflammation. Our findings strongly implicate CD71 in the pathogenesis of CD
Vortex cycles at the inner edges of dead zones  in protoplanetary disks

International audienceContext. In protoplanetary disks, the inner boundary between the turbulent and laminar regions is a promising site for planet formation because solids may become trapped at the interface itself or in vortices generated by the Rossby wave instability. The disk thermodynamics and the turbulent dynamics at that location are entwined because of the importance of turbulent dissipation to thermal ionization and, conversely, of thermal ionization to turbulence. However, most previous work has neglected this dynamical coupling and have thus missed a crucial element of the physics in this region.Aims. In this paper, we aim to determine how the interplay between ionization and turbulence affects the formation and evolution of vortices at the interface between the active and the dead zones.Methods. Using the Godunov code RAMSES, we performed a 3D magnetohydrodynamic global numerical simulation of a cylindrical model of an MRI-turbulent protoplanetary disk, including thermodynamical effects and a temperature-dependant resistivity. The comparison with an analogous 2D viscous simulation was extensively used to help identify the relevant physical processes and the disk’s long-term evolution.Results. We find that a vortex forms at the interface as a result of Rossby wave instability, migrates inward, and penetrates the active zone where it is destroyed by turbulent motions. Subsequently, a new vortex emerges a few tens of orbits later at the interface, and the new vortex migrates inward too. The sequence repeats itself, resulting in cycles of vortex formation, migration, and disruption. This surprising behaviour is successfully reproduced using two different codes. We characterize this vortex life cycle and discuss its implications for planet formation at the dead-active interface. Our results also call for a better understanding of vortex migration in complex thermodynamical environments.Conclusions. Our simulations highlight the importance of thermodynamical processes for the vortex evolution at the dead zone inner edge
Biogeochemistry of fatty acids in a river-dominated Mediterranean ecosystem (Rhône River prodelta, Gulf of Lions, France): Origins and diagenesis

International audienceMajor rivers transfer high loads of continental particulate organic matter to deltaic environments, where the impact on the biogeochemistry and productivity of coastal sediments depends on the sources and lability of these inputs. Our aims are to provide new insights into the reactivity of riverine inputs in coastal environments and to delineate the parameters controlling their fate in these dynamic systems. Sediment cores were collected from a Mediterranean deltaic system (the Rhône prodelta and its adjacent shelf) during a period of moderate river discharge (Spring 2007) and analyzed for their fatty acid composition. Sediment properties were also described using biochemical bulk analyses (organic carbon and lipids), granulometry and profiles of redox potential. Based on the bulk compositional changes and hierarchical clustering of the fatty acid biomarkers, we determined the principal sources of organic matter and their spatial distribution. Fatty acids were primarily of continental origin in the prodelta, shifting to a higher contribution from marine sources in the shelf area. Fatty acids derived from both continental and marine sources were efficiently degraded in the sediments by microbial decay processes in the upper oxic layer. Degradation rate constants calculated from the down-core decreases in concentrations indicate that fatty acid degradation was enhanced in sediments influenced by the Rhône River. The most important parameters affecting fatty acid preservation were the inherent stability of individual molecular components and their physical association with mineral matrices, the source and freshness of the inputs, and the depositional environment (redox condition, accumulation rates)
[C ii] absorption and emission in the diffuse interstellar medium across the Galactic Plane

International audienceIonized carbon is the main gas-phase reservoir of carbon in the neutral diffuse interstellar medium and its 158 µm fine structure transition [C ii] is the most important cooling line of the diffuse interstellar medium (ISM). We combine [C ii] absorption and emission spectroscopy to gain an improved understanding of physical conditions in the different phases of the ISM.. We present high resolution [C ii] spectra obtained with the Herschel/HIFI instrument towards bright dust continuum sources regions in the Galactic plane, probing simultaneously the diffuse gas along the line of sight and the background high-mass star forming regions. These data are complemented by single pointings in the 492 and 809 GHz fine structure lines of atomic carbon and by medium spectral resolution spectral maps of the fine structure lines of atomic oxygen at 63 and 145 µm with Herschel/PACS. We show that the presence of foreground absorption may completely cancel the emission from the background source in medium spectral resolution PACS data and that high spectral resolution spectra are needed to interpret the [C ii] and [O i] emission and the [C ii]/FIR ratio. This phenomenon may explain part of the [C ii]/FIR deficit seen in external luminous infrared galaxies where the bright emission from the nuclear regions may be partially canceled by absorption from diffuse gas in the foreground. The C + and C excitation in the diffuse gas is consistent with a median pressure of ∼ 5900 K cm −3 for a mean kinetic temperature of ∼ 100 K. A few higher pressure regions are detected along the lines of sight, as emission features in both fine structure lines of atomic carbon. The knowledge of the gas density allows us to determine the filling factor of the absorbing gas along the selected lines of sight. The derived median value of the filling factor is 2.4 %, in good agreement with the properties of the Galactic Cold Neutral Medium. The mean excitation temperature is used to derive the average cooling due to C + in the Galactic plane : 9.5 × 10 −26 ergs −1 H −1 . Along the observed lines of sight, the gas phase carbon abundance does not exhibit a strong gradient as a function of Galacto-centric radius and has a weighted average of C/H = 1.5 ± 0.4 × 10 −4
Sulfur and oxygen isotope tracing in zero valent iron based Insitu remediation system for metal contaminants

International audienceIn the present study, controlled laboratory column experiments were conducted to understand the biogeochemical changes during the microbial sulfate reduction. Sulfur and oxygen isotopes of sulfate were followed during sulfate reduction in zero valent iron incubated flow through columns at a constant temperature of 20 ± 1°C for 90 d. Sulfur isotope signatures show considerable variation during biological sulfate reduction in our columns in comparison to abiotic columns where no changes were observed. The magnitude of the enrichment in delta34S values ranged from 9.4 to 10.3‰ compared to initial value of 2.3‰, having total fractionation DELTAS between biotic and abiotic columns as much as 6.1‰. Sulfur isotope fractionation was directly proportional to the sulfate reduction rates in the columns. Oxygen isotopes in this experiment seem less sensitive to microbial activities and more likely to be influenced by isotopic exchange with ambient water. A linear relationship is observed between delta34S and delta18O in biotic conditions and we also highlight a good relationship between delta34S and sulfate reduction rate in biotic columns
Lithogeochemical, mineralogical analyses and oxygen-hydrogen isotopes of the Hercynian Koudiat Aïcha massive sulphide deposit, Morocco

International audienceKoudiat Aïcha is a Visean stratiform, volcanogenic massive sulphide (VMS) zinc-copper-lead deposit, situated northwest of Marrakech, within the Central Domain of the Jebilet massif of the Western Moroccan Meseta. The Central Domain is formed mainly of sedimentary (argillite, siltstone, sandstone, carbonate) and magmatic (gabbro and rhyodacite) rocks that host numerous massive sulphide deposits (e.g., Koudiat Aïcha, Kettara and Draa Sfar) in a thick grayish argillite sequence (rhythmic metapelite). The deposit is stratabound and consists of highly deformed, sheet-like lenses of massive sulphide located structurally on the eastern flank of a large anticline. Prior to metamorphism, the country rocks were subjected to hydrothermal alteration which is particularly pronounced in the immediate vicinity of the sulphide deposits where chloritization and sericitization are prevalent. Hydrothermal alteration extends into both the stratigraphic footwall and the stratigraphic hanging wall. The footwall lacks an obvious pipe zone (sulphide stringers or vent complex) beneath the sulphide mineralization, but is characterized by an increase in the modal proportion of Mg-chlorite and by the breakdown of feldspar and sericite. Chloritization, the most extensive and readily recognizable alteration useful in mineral exploration, is evident for more than 60 m above the subcropping sulphide deposits. The hanging wall rocks show a pervasive sericitization (over 30 m wide) and a weak chlorite alteration accompanied by disseminated nodules of pyrrhotite stretched parallel to the S1 foliation. Because chlorite and sericite are metamorphic minerals that also occur in unaltered rocks surrounding the sulphide deposits, abundant Mg-rich chlorite and the absence of feldspar in the footwall are used to distinguish hydrothermal alteration facies from metamorphic facies. The chlorite geothermometer reveals temperatures between 250 and 330 °C. Higher temperatures (up to 300 °C) are associated with chlorite located in and adjacent to sulphide mineralization, whereas lower temperatures correlate with distal chlorite in both the footwall and hanging wall rocks. Chemical trends in altered footwall rocks are shown by absolute mass gains for Fe2O3total, MnO and MgO, by absolute mass losses for CaO, K2O and Na2O, and by a moderate loss in SiO2. Oxygen and hydrogen isotope compositions of Koudiat Aïcha lithofacies (6.2-12.4‰ for oxygen and −51‰ to −36‰ for hydrogen) have also been used to determine the temperature and origin of metalliferous fluids. The couple plagioclase-amphibole of gabbros provides equilibrium temperatures between 310 and 380 °C and suggests that the heat source for the ore-forming fluid system may have been igneous. On the other hand, oxygen and hydrogen isotope ratios cluster between normal values for sedimentary and magmatic rocks, suggesting a magmatic-metamorphic origin for the ore fluid