pinecone/core-2020-05-10-deduplication huggingface dataset:
Apoptotic markers in cultured fibroblasts correlate with brain metabolites and regional brain volume in antipsychotic-naive first-episode schizophrenia and healthy controls

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                  152783.pdf (publisher's version ) (Open Access)Cultured fibroblasts from first-episode schizophrenia patients (FES) have shown increased susceptibility to apoptosis, which may be related to glutamate dysfunction and progressive neuroanatomical changes. Here we determine whether apoptotic markers obtained from cultured fibroblasts in FES and controls correlate with changes in brain glutamate and N-acetylaspartate (NAA) and regional brain volumes. Eleven antipsychotic-naive FES and seven age- and gender-matched controls underwent 3-Tesla magnetic resonance imaging scanning. Glutamate plus glutamine (Glx) and NAA levels were measured in the anterior cingulate (AC) and the left thalamus (LT). Hallmarks of apoptotic susceptibility (caspase-3-baseline activity, phosphatidylserine externalization and chromatin condensation) were measured in fibroblast cultures obtained from skin biopsies after inducing apoptosis with staurosporine (STS) at doses of 0.25 and 0.5 muM. Apoptotic biomarkers were correlated to brain metabolites and regional brain volume. FES and controls showed a negative correlation in the AC between Glx levels and percentages of cells with condensed chromatin (CC) after both apoptosis inductions (STS 0.5 muM: r = -0.90; P = 0.001; STS 0.25 muM: r = -0.73; P = 0.003), and between NAA and cells with CC (STS 0.5 muM induction r = -0.76; P = 0.002; STS 0.25 muM r = -0.62; P = 0.01). In addition, we found a negative correlation between percentages of cells with CC and regional brain volume in the right supratemporal cortex and post-central region (STS 0.25 and 0.5 muM; P < 0.05 family-wise error corrected (FWEc)). We reveal for the first time that peripheral markers of apoptotic susceptibility may correlate with brain metabolites, Glx and NAA, and regional brain volume in FES and controls, which is consistent with the neuroprogressive theories around the onset of the schizophrenia illness
Introducing Relational Work in Facebook and Discussion Boards

This paper functions as the introduction to the special issue on ‘relational work in Facebook and discussion boards’. We position our research endeavors within interpersonal pragmatics (see Locher and Graham 2010), by reviewing literature on politeness, impoliteness and relational work in the context of computer-mediated communication. Foregrounding the relational aspect of language, we are particularly interested in establishing the connections between politeness, face and linguistic identity construction. We then position the four papers that form this special issue within this field of research. Two papers contribute to the study of relational work on discussion boards (Kleinke and Boes; Haugh, Chang and Kádár) and two deal with practices on Facebook (Theodoropoulou; Bolander and Locher).published_or_final_versio
Measurement of the w(+/-)z production cross section and limits on anomalous triple gauge couplings in proton-proton collisions at root s=7 TeV with the ATLAS detector

This Letter presents a measurement of W(+/-)Z production in 1.02 fb(-1) of pp collision data at root s = 7 TeV collected by the ATLAS experiment in 2011. Doubly leptonic decay events are selected with electrons, muons and missing transverse momentum in the final state. In total 71 candidates are observed, with a background expectation of 12.1 +/- 1.4(stat.)(-2.0)(+4.1)(syst.) events. The total cross section for W(+/-)Z production for Z/gamma* masses within the range 66 GeV to 116 GeV is determined to be sigma(tot)(WZ) = 20.5(-2.8)(+3.1)(stat.)(-1.3)(+1.4)(syst)(-0.8)(+0.9)(lumi.) pb, which is consistent with the Standard Model expectation of 17.3(0.8)(+1.3) pb. Limits on anomalous triple gauge boson couplings are extracted
An overview of cardiac morphogenesis.

International audienceAccurate knowledge of normal cardiac development is essential for properly understanding the morphogenesis of congenital cardiac malformations that represent the most common congenital anomaly in newborns. The heart is the first organ to function during embryonic development and is fully formed at 8 weeks of gestation. Recent studies stemming from molecular genetics have allowed specification of the role of cellular precursors in the field of heart development. In this article we review the different steps of heart development, focusing on the processes of alignment and septation. We also show, as often as possible, the links between abnormalities of cardiac development and the main congenital heart defects. The development of animal models has permitted the unraveling of many mechanisms that potentially lead to cardiac malformations. A next step towards a better knowledge of cardiac development could be multiscale cardiac modelling
Spatially resolved physical conditions of molecular gas and potential star formation tracers in M 83, revealed by the Herschel SPIRE FTS

International audienceWe investigate the physical properties of the molecular and ionized gas, and their relationship to the star formation and dust properties in M 83, based on submillimeter imaging spectroscopy from within the central 3.5′ (~4 kpc in diameter) around the starburst nucleus. The observations use the Fourier Transform Spectrometer (FTS) of the Spectral and Photometric Imaging REceiver (SPIRE) onboard the Herschel Space Observatory. The newly observed spectral lines include [CI]  370 μm, [CI]  609 μm, [NII]  205 μm, and CO transitions from J = 4−3 to J = 13−12. Combined with previously observed J = 1−0 to J = 3−2 transitions, the CO spectral line energy distributions are translated to spatially resolved physical parameters, column density of CO, N(CO), and molecular gas thermal pressure, Pth, with a non-local thermal equilibrium (non-LTE) radiative transfer model, RADEX. Our results show that there is a relationship between the spatially resolved intensities of [NII]  205 μm and the surface density of the star formation rate (SFR), ΣSFR. This relation, when compared to integrated properties of ultra-luminous infrared galaxies (ULIRGs), exhibits a different slope, because the [NII]  205 μm distribution is more extended than the SFR. The spatially resolved [CI]  370 μm, on the other hand, shows a generally linear relationship with ΣSFR and can potentially be a good SFR tracer. Compared with the dust properties derived from broad-band images, we find a positive trend between the emissivity of CO in the J = 1−0 transition with the average intensity of interstellar radiation field (ISRF), ⟨ U ⟩. This trend implies a decrease in the CO-to-H2 conversion factor, XCO, when ⟨ U ⟩ increases. We estimate the gas-to-dust mass ratios to be 77 ± 33 within the central 2 kpc and 93 ± 19 within the central 4 kpc of M 83, which implies a Galactic dust-to-metal mass ratio within the observed region of M 83. The estimated gas-depletion time for the M 83 nucleus is 1.13 ± 0.6 Gyr, which is shorter than the values for nearby spiral galaxies found in the literature (~2.35 Gyr), most likely due to the young nuclear starbursts. A linear relationship between Pth and the radiation pressure generated by ⟨ U ⟩, Prad, is found to be Pth ≈ 30 Prad, which signals that the ISRF alone is insufficient to sustain the observed CO transitions. The spatial distribution of Pth reveals a pressure gradient, which coincides with the observed propagationof starburst activities and the alignment of (possibly background) radio sources. We discover that the off-centered (from the optical nucleus) peak of the molecular gas volume density coincides well with a minimum in the relative aromatic feature strength, indicating a possible destruction of their carriers. We conclude that the observed CO transitions are most likely associated with mechanical heating processes that are directly or indirectly related to very recent nuclear starbursts
Pair-vibrational states in the presence of neutron-proton pairing

7 pages, 3 tables, 1 figure, accepted for publication in Physics Letters BPair vibrations are studied for a Hamiltonian with neutron-neutron, proton-proton and neutron-proton pairing. The spectrum is found to be rich in strongly correlated, low-lying excited states. Changing theratio of diagonal to off-diagonal pairing matrix elements is found to have a large impact on the excited-state spectrum. The variational configuration interaction (VCI) method, used to calculate the excitation spectrum, is found to be in very good agreement with exact solutions for systems with large degeneracies having equal $T=0$ and $T=1$ pairing strengths
Continuously varying coupled transmission lines applied to design band-pass filters

International audienceThis article presents a technique to analyze and optimize Continuously Varying Transmission Lines (CVTL's), used to design microwave band-pass filters in planar technology. For millimeters waves, radiation losses can increase quickly, especially for sharp discontinuities in planar circuits. In this approach, rather than taking account of this effect in a full-wave analysis, we generate structures without discontinuities. Moreover, the line shape is optimized to reduce spurious responses out of the band-pass. For several filters, measurements are compared with simulation results
Multifocal Ectopic Purkinje-Related Premature Contractions: A New SCN5A-Related Cardiac Channelopathy.
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MEPPC: a new SCN5A-related cardiac channelopathy

International audienceOBJECTIVES: The aim of this study was to describe a new familial cardiac phenotype and to elucidate the electrophysiological mechanism responsible for the disease. BACKGROUND: Mutations in several genes encoding ion channels, especially SCN5A, have emerged as the basis for a variety of inherited cardiac arrhythmias. METHODS: Three unrelated families comprising 21 individuals affected by multifocal ectopic Purkinje-related premature contractions (MEPPC) characterized by narrow junctional and rare sinus beats competing with numerous premature ventricular contractions with right and/or left bundle branch block patterns were identified. RESULTS: Dilated cardiomyopathy was identified in 6 patients, atrial arrhythmias were detected in 9 patients, and sudden death was reported in 5 individuals. Invasive electrophysiological studies demonstrated that premature ventricular complexes originated from the Purkinje tissue. Hydroquinidine treatment dramatically decreased the number of premature ventricular complexes. It normalized the contractile function in 2 patients. All the affected subjects carried the c.665G>A transition in the SCN5A gene. Patch-clamp studies of resulting p.Arg222Gln (R222Q) Nav1.5 revealed a net gain of function of the sodium channel, leading, in silico, to incomplete repolarization in Purkinje cells responsible for premature ventricular action potentials. In vitro and in silico studies recapitulated the normalization of the ventricular action potentials in the presence of quinidine. CONCLUSIONS: A new SCN5A-related cardiac syndrome, MEPPC, was identified. The SCN5A mutation leads to a gain of function of the sodium channel responsible for hyperexcitability of the fascicular-Purkinje system. The MEPPC syndrome is responsive to hydroquinidine
Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb–Pb collisions at √sNN = 2.76 TeV

The centrality dependence of the charged-particle pseudorapidity density measured with ALICE in Pb–Pb collisions at √sNN = 2.76 TeV over a broad pseudorapidity range is presented. This Letter extends the previous results reported by ALICE to more peripheral collisions. No strong change of the overall shape of charged-particle pseudorapidity density distributions with centrality is observed, and when normalised to the number of participating nucleons in the collisions, the evolution over pseudorapidity with centrality is likewise small. The broad pseudorapidity range (−3.5 < η < 5) allows precise estimates of the total number of produced charged particles which we find to range from 162 ± 22(syst.) to 17170 ± 770(syst.) in 80–90% and 0–5% central collisions, respectively. The total charged-particle multiplicity is seen to approximately scale with the number of participating nucleons in the collision. This suggests that hard contributions to the charged-particle multiplicity are limited. The results are compared to models which describe dNch/dη at mid-rapidity in the most central Pb–Pb collisions and it is found that these models do not capture all features of the distributions
Marginal Activity Access Cost (MAAC): a new indicator for\ud
sustainable Land Use/Transport (LUT) planning

The paper presents the 'Marginal Activity Access Cost', an accessibility indicator providing estimation in monetary terms of the impacts on mobility and on the environment of locating a single new activity in a specific zone of the urban area. In the first part of this paper, the new indicator is presented and compared to other accessibility indicators proposed in literature. In the second part, the MAAC is validated through an application to the urban area of Rome. The paper concludes with brief remarks on using the proposed accessibility indicator as index of performance for sustainable spatial planning
Fps1p channel is the mediator of the major part of glycerol passive diffusion in Saccharomyces cerevisiae : artefacts and re-definitions

Glycerol has been shown to cross Saccharomyces cerevisiae plasma membrane (1) through a H+/symport detected in cells grown on non-fermentable carbon sources, (2) by passive diffusion and (3) through the constitutive Fps1p channel. This has been named a facilitator, for mediating glycerol low affinity transport of the facilitated diffusion type. We present experimental evidence that this kinetics is an artefact created by glycerol kinase activity. Instead, the channel is shown to mediate the major part of glycerol passive diffusion. Nevertheless, Fps1p major role in vivo has been previously shown to be the control of glycerol export under osmotic stress or in reaction to turgor changes. Overexpressing FPS1 caused an increase in H+/symport V_max. Moreover, yfl054c and fps1 mutants were equally affected by exogenously added ethanol, being the correspondent passive diffusion stimulated. This is, to our knowledge, the first time that a phenotype can be attributed to the functioning of YFL054c gene. Glycerol passive diffusion is thus apparently channel mediated. This is discussed according to glycerol chemical properties, which contradict the widely spread concept of glycerol lipossoluble nature. The discussion considers the multiple roles that glycerol intracellular levels and its pathway regulation might play as a central key to metabolism control.EC contract PL 950161 from BIOTECH - Cell Factories Program
Project management success in health: the need of additional research in public health projects

PROJMAN 2014 - International Conference on Project MANagement, Procedia TechnologyThe research about the factors that are linked to project management performance and project management success,
has been developed for several years, so the literature about this subject is relatively extensive. After a
literature review about project success factors, it was found that the current research effort is mainly focused on
information technology, engineering and software development projects, not yet on public health projects. Public
health projects have a different focus, are concerned on providing conditions in which people can be healthy, and are
essential for populations’ welfare. Their distinctive attributes justify the need of research towards the development
of a specific model of success factors, to support top management and project managers in planning and operational
management. A model of success factors would help in the identification, control and minimization of issues that
increase the likelihood of going in the wrong direction and strengthen those that create value or increase the
probability of going successfully. It would also be useful as a tool for prediction and diagnosis in evaluating
objectively and gradually minimize the probability of project failure, and thus assist in improving the project
performance. This article presents a brief literature review on project management success and points out the need of
additional research for public health projects in this area
Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s√=8 TeV with the ATLAS detector

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider (LHC) are reported. The search is based on proton-proton collision data at a centre-of-mass energy s√=8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb−1. No significant excess above the Standard Model expectation is observed. Limits are set on the parameters of a minimal universal extra dimensions model, excluding a compactification radius of 1/Rc=950 GeV for a cut-off scale times radius (ΛRc) of approximately 30, as well as on sparticle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT and NSRF, Greece; RGC, Hong Kong SAR, China; ISF, MINERVA, GIF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW and NCN, Poland; GRICES and FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America
Amalgamations of factorizations of complete equipartite graphs.

Let t be a positive integer, and let L=(l1,…,lt) and K=(k1,…,kt) be collections of nonnegative integers. A graph has a (t,K,L) factorization if it can be represented as the edge-disjoint union of factors F1,…,Ft where, for 1it, Fi is ki-regular and at least li-edge-connected. In this paper we consider (t,K,L)-factorizations of complete equipartite graphs. First we show precisely when they exist. Then we solve two embedding problems: we show when a factorization of a complete σ-partite graph can be embedded in a (t,K,L)-factorization of a complete s-partite graph, σ<s, and also when a factorization of Ka,b can be embedded in a (t,K,L)-factorization of Kn,n, a,bn. Our proofs use the technique of amalgamations of graphs.Let t be a positive integer, and let L=(l1,…,lt) and K=(k1,…,kt) be collections of nonnegative integers. A graph has a (t,K,L) factorization if it can be represented as the edge-disjoint union of factors F1,…,Ft where, for 1it, Fi is ki-regular and at least li-edge-connected. In this paper we consider (t,K,L)-factorizations of complete equipartite graphs. First we show precisely when they exist. Then we solve two embedding problems: we show when a factorization of a complete σ-partite graph can be embedded in a (t,K,L)-factorization of a complete s-partite graph, σ<s, and also when a factorization of Ka,b can be embedded in a (t,K,L)-factorization of Kn,n, a,bn. Our proofs use the technique of amalgamations of graphs
Ceilings and Floors? Gender Wage Gaps by Education in Spain

Revised: 2006-11.-- Published as an article in: Journal of Population Economics, 2007, vol. 21 issue 3, pp. 751-776.This paper analyses the gender wage gaps by education throughout the wage distribution in Spain using individual data from the ECHP (1999). Quantile regressions are used to estimate the wage returns to the different characteristics at the more relevant percentiles and a suitable version of the Oaxaca-Blinder decomposition is then implemented to estimate the component of the gender gap not explained by different characteristics. Our main findings are twofold. First, in contrast with the steep pattern found for other countries, the flatter evolution of the gap found in Spain hides a composition effect when the sample is split by education. On the one hand, for the group with college/tertiary education, we find a higher unexplained gap at the top than at the bottom of the distribution, in accordance with the conventional glass ceiling hypothesis. On the other, for the group with lower education, the gap is much higher at the bottom than at the top of the distribution. We label this novel pattern as glass floors and argue that it is due to statistical discrimination exerted by employers in view of the low participation rate of women in this group. Such a hypothesis is confirmed when using the panel structure of the ECHP
Propagation of short period (10-40min) atmospheric gravity waves from troposphere to mesosphere over Gadanki, India

The Indian MST radar at Gadanki (13.5Â°N, 79.2Â°E) has been utilised to conduct a detailed study of the close coupling between the troposphere and the mesosphere through the vertically propagating atmospheric gravity waves. For this purpose two cases from a special campaign dedicated to the simultaneous measurement of the fluctuations in the UTLS (Upper Troposphere and Lower Stratosphere) and in the mesosphere during 2001 and one case from a follow up observation in 2002 have been investigated. By using both the FFT and wavelet techniques, the near simultaneous tropospheric and mesospheric data of radar return signal strengths and tropospheric wind fields are analysed. The signatures of relatively high frequency gravity waves with periods between ~10 and 40. min have been clearly traced as propagating waves from the tropospheric turbulent layer heights (~8-18. km) to the lower mesospheric heights (65-80. km). Significant peak correlation coefficients of 0.56 and 0.45 have been found between the SNR time series of pairs of troposphere and mesosphere levels indicating the propagation of high speed gravity waves. The time series of wavelet spectra determined for the tropospheric SNR/zonal winds and the mesospheric SNR show that the detectability of the gravity waves increases at mesospheric heights. It is shown that the continuous SNR values received from the mesosphere can be used as an effective parameter for studies featuring mesospheric wave dynamics. Based on the observed values of vertical wavelengths and wave amplitudes, the horizontal wavelengths, wave phase and group velocities have been estimated for different wave periods. These results have implications on monitoring of the ubiquitous atmospheric gravity waves generated mainly by the tropospheric weather system of the tropical region from their imprint on the mesospheric turbulence structures. Â© 2015 Elsevier Ltd