pinecone/core-2020-05-10-deduplication huggingface dataset:
Essential basic and emergency obstetric and newborn care: From education and training to service delivery and quality of care

AbstractApproximately 15% of expected births worldwide will result in life-threatening complications during pregnancy, delivery, or the postpartum period. Providers skilled in emergency obstetric and newborn care (EmONC) services are essential, particularly in countries with a high burden of maternal and newborn mortality. Jhpiego and its consortia partners have implemented three global programs to build provider capacity to provide comprehensive EmONC services to women and newborns in these resource-poor settings. Providers have been educated to deliver high-impact maternal and newborn health interventions, such as prevention and treatment of postpartum hemorrhage and pre-eclampsia/eclampsia and management of birth asphyxia, within the broader context of quality health services. This article describes Jhpiego’s programming efforts within the framework of the basic and expanded signal functions that serve as indicators of high-quality basic and emergency care services. Lessons learned include the importance of health facility strengthening, competency-based provider education, global leadership, and strong government ownership and coordination as essential precursors to scale-up of high impact evidence-based maternal and newborn interventions in low-resource settings
The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

SummaryHIV-2 is less pathogenic for humans than HIV-1 and might provide partial cross-protection from HIV-1-induced pathology. Although both viruses replicate in the T cells of infected patients, only HIV-2 replicates efficiently in dendritic cells (DCs) and activates innate immune pathways. How HIV is sensed in DC is unknown. Capsid-mutated HIV-2 revealed that sensing by the host requires viral cDNA synthesis, but not nuclear entry or genome integration. The HIV-1 capsid prevented viral cDNA sensing up to integration, allowing the virus to escape innate recognition. In contrast, DCs sensed capsid-mutated HIV-1 and enhanced stimulation of T cells in the absence of productive infection. Finally, we found that DC sensing of HIV-1 and HIV-2 required the DNA sensor cGAS. Thus, the HIV capsid is a determinant of innate sensing of the viral cDNA by cGAS in dendritic cells. This pathway might potentially be harnessed to develop effective vaccines against HIV-1
Kählerian effective potentials for Chern–Simons-matter theories

AbstractIn this paper, we will calculate the effective potential for a theory of multiple M2-branes. As the theory of multiple M2-branes can be described by a Chern–Simons-matter theory, this will be done by calculating the Kählerian effective potential for a Chern–Simons-matter theory. This calculation will be performed in N=1 superspace formalism. We will initially study an Abelian Chern–Simons-matter theory, and then generalize those results to the full non-Abelian Chern–Simons-matter theory. We will obtain explicit expressions for the superpropagators for this theory. These superpropagators will be used to calculate the one-loop effective potential
Association between participation in outdoor play and sport at 10years old with physical activity in adulthood

AbstractObjectiveThis study aimed to investigate whether active outdoor play and/or sports at age 10 is associated with sport/physical activity at 32year follow-up using a birth cohort study.MethodsData were from the 1970 British Cohort Study, a longitudinal observational study. The present paper included data from the age 10years and age 42years surveys. At age 10 the participant's mother provided information regarding how often their child played sports, and played outside on streets, parks or playgrounds. At age 42 participants reported frequency of participation in physical activities and sports. Associations between participation in sport/active outdoor play at age 10years and adult sport/physical activity were investigated using adjusted (gender, fathers socio-occupational class, child's BMI, father's BMI, self-rated health at age 42, assessment of own weight at age 42, participant's education) Cox regression.ResultsFinal adjusted Cox regression models showed that participants (n=6458) who often participated in sports at age 10 were significantly more likely to participate in sport/physical activity at age 42 (RR 1.10; 95% CI 1.01 to 1.19). Active outdoor play at age 10 was not associated with participation in sport/physical activity at age 42 (RR 0.99; 95% CI 0.91 to 1.07).ConclusionChildhood activity interventions might best achieve lasting change by promoting engagement in sport rather than active outdoor play
Global well-posedness for the micropolar fluid system in critical Besov spaces

AbstractWe prove the global well-posedness for the 3-D micropolar fluid system in the critical Besov spaces by making a suitable transformation of the solutions and using the Fourier localization method, especially combined with a new Lp estimate for the Green matrix to the linear system of the transformed equation. This result allows to construct global solutions for a class of highly oscillating initial data of Cannoneʼs type. Meanwhile, we analyze the long-time behavior of the solutions and get some decay estimates
A new noncommutative product on the fuzzy two-sphere corresponding to the unitary representation of SU(2) and the Seiberg–Witten map

AbstractWe obtain a new explicit expression for the noncommutative (star) product on the fuzzy two-sphere which yields a unitary representation. This is done by constructing a star product, ★λ, for an arbitrary representation of SU(2) which depends on a continuous parameter λ and searching for the values of λ which give unitary representations. We will find two series of values: λ=λ(A)j=1/(2j) and λ=λ(B)j=−1/(2j+2), where j is the spin of the representation of SU(2). At λ=λ(A)j the new star product ★λ has poles. To avoid the singularity the functions on the sphere must be spherical harmonics of order ℓ⩽2j and then ★λ reduces to the star product ★ obtained by Pres̆najder [hep-th/9912050]. The star product at λ=λ(B)j, to be denoted by •, is new. In this case the functions on the fuzzy sphere do not need to be spherical harmonics of order ℓ⩽2j. The star product ★λ has no singularity for negative values of λ and we can move from one representation λ=λ(B)j to another λ=λ(B)j′ smoothly on the negative λ line. Because in this case there is no cutoff on the order of spherical harmonics, the degrees of freedom of the gauge fields on the fuzzy sphere coincide with those on the commutative sphere. Therefore, although the field theory on the fuzzy sphere is a system with finite degrees of freedom, we can expect the existence of the Seiberg–Witten map between the noncommutative and commutative descriptions of the gauge theory on the sphere. We will derive the first few terms of the Seiberg–Witten map for the U(1) gauge theory on the fuzzy sphere by using power expansion around the commutative point λ=0
Erdős–Ko–Rado theorems for simplicial complexes

AbstractA recent framework for generalizing the Erdős–Ko–Rado theorem, due to Holroyd, Spencer, and Talbot, defines the Erdős–Ko–Rado property for a graph in terms of the graph's independent sets. Since the family of all independent sets of a graph forms a simplicial complex, it is natural to further generalize the Erdős–Ko–Rado property to an arbitrary simplicial complex. An advantage of working in simplicial complexes is the availability of algebraic shifting, a powerful shifting (compression) technique, which we use to verify a conjecture of Holroyd and Talbot in the case of sequentially Cohen–Macaulay near-cones
Targeted Suppression of EVI1 Oncogene Expression by Sequence-Specific Pyrrole-Imidazole Polyamide

SummaryHuman ectopic viral integration site 1 (EVI1) is an oncogenic transcription factor known to play a critical role in many aggressive forms of cancer. Its selective modulation is thought to alter the cancer-specific gene regulatory networks. Pyrrole-imidazole polyamides (PIPs) are a class of small DNA binders that can be designed to target any destined DNA sequence. Herein, we report a sequence-specific pyrrole-imidazole polyamide, PIP1, which can target specific base pairs of the REL/ELK1 binding site in the EVI1 minimal promoter. The designed PIP1 significantly inhibited EVI1 in MDA-MB-231 cells. Whole-transcriptome analysis confirmed that PIP1 affected a fraction of EVI1-mediated gene regulation. In vitro assays suggested that this polyamide can also effectively inhibit breast cancer cell migration. Taken together, these results suggest that EVI1-targeted PIP1 is an effective transcriptional regulator in cancer cells
Hybrid Coronary Revascularization Promising, But Yet to Take Off

AbstractHybrid coronary revascularization (HCR) combines arterial coronary artery bypass surgery (most commonly minimally invasive) and percutaneous coronary intervention in the treatment of a particular subset of multivessel coronary artery disease. It was first introduced in the mid-1990s, and aspired to bring together the “best of both worlds”: the excellent patency rates and survival benefits associated with the durable left internal mammary artery graft to the left anterior descending artery alongside the good patency rates of drug-eluting stents, which outlive saphenous vein grafts to non–left anterior descending vessels. Although in theory this is a very attractive revascularization strategy, several years later, only one small randomized controlled trial comparing HCR with coronary artery bypass grafting has recently emerged in the medical literature, raising concerns regarding HCR’s role and generalizability. In the current review, we discuss HCR’s rationale, the current evidence behind it, its limitations and procedural challenges
Reconciling Planck with the local value of H0 in extended parameter space

AbstractThe recent determination of the local value of the Hubble constant by Riess et al., 2016 (hereafter R16) is now 3.3 sigma higher than the value derived from the most recent CMB anisotropy data provided by the Planck satellite in a ΛCDM model. Here we perform a combined analysis of the Planck and R16 results in an extended parameter space, varying simultaneously 12 cosmological parameters instead of the usual 6. We find that a phantom-like dark energy component, with effective equation of state w=−1.29−0.12+0.15 at 68% c.l. can solve the current tension between the Planck dataset and the R16 prior in an extended ΛCDM scenario. On the other hand, the neutrino effective number is fully compatible with standard expectations. This result is confirmed when including cosmic shear data from the CFHTLenS survey and CMB lensing constraints from Planck. However, when BAO measurements are included we find that some of the tension with R16 remains, as also is the case when we include the supernova type Ia luminosity distances from the JLA catalog
A search for excited neutrinos in e−p collisions at HERA

AbstractA search for first generation excited neutrinos is performed using the full e−p data sample collected by the H1 experiment at HERA at a centre-of-mass energy of 319 GeV, corresponding to a total luminosity of 184 pb−1. The electroweak decays of excited neutrinos ν∗→νγ, ν∗→νZ and ν∗→eW with subsequent hadronic or leptonic decays of the W and Z bosons are considered. No evidence for excited neutrino production is found. Mass dependent exclusion limits on ν∗ production cross sections and on the ratio of the coupling to the compositeness scale f/Λ are derived within gauge mediated models. A limit on f/Λ, independent of the relative couplings to the SU(2) and U(1) gauge bosons, is also determined. These limits extend the excluded region to higher masses than has been possible in previous excited neutrino searches
Splitting mass spectra and muon g−2 in Higgs-anomaly mediation

AbstractWe propose a scenario where only the Higgs multiplets have direct couplings to a supersymmetry (SUSY) breaking sector. The standard model matter multiplets as well as the gauge multiples are sequestered from the SUSY breaking sector; therefore, their masses arise via anomaly mediation at the high energy scale with a gravitino mass of ∼100TeV. Due to renormalization group running effects from the Higgs soft masses, the masses of the third generation sfermions become O(10)TeV at the low energy scale, while the first and second generation sfermion masses are O(0.1-1)TeV, avoiding the tachyonic slepton problem and flavor changing neutral current problem. With the splitting mass spectrum, the muon g−2 anomaly is explained consistently with the observed Higgs boson mass of 125 GeV. Moreover, the third generation Yukawa couplings are expected to be unified in some regions
Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III–IV linker

AbstractResurgent sodium currents likely play a role in modulating neuronal excitability. Here we studied whether protein kinase C (PKC) activation can increase resurgent currents produced by the human sodium channel hNav1.7. We found that a PKC agonist significantly enhanced hNav1.7-mediated resurgent currents and this was prevented by PKC antagonists. The enhancing effects were replicated by two phosphorylation-mimicking mutations and were prevented by a phosphorylation-deficient mutation at a conserved PKC phosphorylation site (Serine 1479). Our results suggest that PKC can increase sodium resurgent currents through phosphorylation of a conserved Serine residue located in the domain III–IV linker of sodium channels
Building SO10-models with D4 symmetry

AbstractUsing characters of finite group representations and monodromy of matter curves in F-GUT, we complete partial results in literature by building SO10 models with dihedral D4 discrete symmetry. We first revisit the S4-and S3-models from the discrete group character view; then we extend the construction to D4. We find that there are three types of SO10×D4 models depending on the ways the S4-triplets break down in terms of irreducible D4-representations: (α) as 1+,−⊕1+,−⊕1−,+; or (β)1+,+⊕1+,−⊕1−,−; or also (γ) 1+,−⊕20,0. Superpotentials and other features are also given
Banking Services in Terms of Changing Environment: The Case of Мacedonia

AbstractThe aim of this paper is to elaborate the impact of the changing environment on the services that the banking sector is providing. The trends in the international banking will be analyzed also from the perspective of the banking activities on Macedonian banks. Speaking of changes, there are two tendencies that can be determined in the international banking: 1) increased competition that influence on the banking products and pricing, 2) technology improvements that affects the distribution channels of selling and the operating cost on the banking activities. Increased competition and sharing the same target market along with other financial institutions affects the banks’ market share and prices of their products. In developed economies there is a trend of suppression of banks from certain market segments and reducing their market share. This trend is mostly expressed in USA and is less pronounced in EU. Also rapid technology development and penetration of Internet in everyday life doesn’t leave immune nor the banking sector. The technological improvements affect the banking industry through introduction of new products, increasing efficiency in terms of operating costs and developing new distribution channels. Banks are forced to adapt their products to a new generation that is coming and who grew up in the Internet Age. The biggest changes have been made in terms of payment methods by allowing transactions to be made 24hours a day from anywhere. The development of technology also affects on the improvement of data bases which enable better assessment of credit risk to individual products and customers. Banks along with other financial institutions are joining in collecting and sharing of customer data that enables better assessment of the credit risk
Study of ψ(3770) decaying to baryon anti-baryon pairs

AbstractTo study the decays of ψ(3770) going to baryon anti-baryon pairs (BB¯), all available experiments of measuring the cross sections of e+e−→BB¯ at center-of-mass energy ranging from 3.0 GeV to 3.9 GeV are combined. To relate the baryon octets, a model based on the SU(3) flavor symmetry is used and the SU(3) breaking effects are also considered. Assuming the electric and magnetic form factors are equal (|GE|=|GM|), a global fit including the interference between the QED process and the resonant process is performed. The branching fraction of ψ(3770)→BB¯ is determined to be (2.4±0.8±0.3)×10−5, (1.7±0.6±0.1)×10−5, (4.5±0.9±0.1)×10−5, (4.5±0.9±0.1)×10−5, (2.0±0.7±0.1)×10−5, and (2.0±0.7±0.1)×10−5 for B=p,Λ,Σ+,Σ0,Ξ− and Ξ0, respectively, where the first uncertainty is from the global fit and the second uncertainty is the systematic uncertainty due to the assumption |GE|=|GM|. They are at least one order of magnitude larger than a simple scaling of the branching fraction of J/ψ/ψ(3686)→BB¯
The thermal width of heavy quarkonia moving in quark–gluon plasma

AbstractThe velocity dependence of the thermal width of heavy quarkonia traveling with respect to the quark–gluon plasma is calculated up to the NLO in perturbative QCD. At the LO, the width decreases with increasing speed, whereas at the NLO it increases with a magnitude approximately proportional to the expectation value of the relative velocity between the quarkonium and a parton in thermal equilibrium. Such an asymptotic behavior is due to the NLO dissociation cross section converging to a nonvanishing value in the high energy limit
One-loop weak corrections to the bb̄ cross section at TeV energy hadron colliders

AbstractWe investigate one-loop weak corrections to the production cross section of two b-jets at Tevatron and Large Hadron Collider (LHC). We establish that they are small at inclusive level but dominant in exclusive observables that have a non-trivial dependence on the helicity structure of the hard subprocesses. Such effects can serve as a test of the Standard Model (SM) and, conversely, they should be taken into account in future experimental analyses aiming at extracting possible signals of new physics
Combination of searches for WW, WZ, and ZZ resonances in pp collisions at s=8 TeV with the ATLAS detector

AbstractThe ATLAS experiment at the CERN Large Hadron Collider has performed searches for new, heavy bosons decaying to WW, WZ and ZZ final states in multiple decay channels using 20.3 fb−1 of pp collision data at s=8 TeV. In the current study, the results of these searches are combined to provide a more stringent test of models predicting heavy resonances with couplings to vector bosons. Direct searches for a charged diboson resonance decaying to WZ in the ℓνℓ′ℓ′ (ℓ=μ,e), ℓℓqq¯, ℓνqq¯ and fully hadronic final states are combined and upper limits on the rate of production times branching ratio to the WZ bosons are compared with predictions of an extended gauge model with a heavy W′ boson. In addition, direct searches for a neutral diboson resonance decaying to WW and ZZ in the ℓℓqq¯, ℓνqq¯, and fully hadronic final states are combined and upper limits on the rate of production times branching ratio to the WW and ZZ bosons are compared with predictions for a heavy, spin-2 graviton in an extended Randall–Sundrum model where the Standard Model fields are allowed to propagate in the bulk of the extra dimension
Vector-like pairs and Brill–Noether theory

AbstractHow likely is it that there are particles in a vector-like pair of representations in low-energy spectrum, when neither symmetry nor anomaly consideration motivates their presence? We address this question in the context of supersymmetric and geometric phase compactification of F-theory and Heterotic dual. Quantisation of the number of generations (or net chiralities in more general term) is also discussed along the way. Self-dual nature of the fourth cohomology of Calabi–Yau fourfolds is essential for the latter issue, while we employ Brill–Noether theory to set upper bounds on the number ℓ of vector-like pairs of chiral multiplets in the SU(5)GUT (5+5¯) representations. For typical topological choices of geometry for F-theory compactification for SU(5) unification, the range of 0≤ℓ≲4 for perturbative unification is not in immediate conflict with what is already understood about F-theory compactification at this moment
A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production

SummaryAbnormal accumulation of β-secretase (BACE1) in dystrophic neurites and presynaptic β-amyloid (Aβ) production contribute to Alzheimer's disease pathogenesis. Little, however, is known about BACE1 sorting and dynamic transport in neurons. We investigated BACE1 trafficking in hippocampal neurons using live-cell imaging and selective labeling. We report that transport vesicles containing internalized BACE1 in dendrites undergo exclusive retrograde transport toward the soma, whereas they undergo bidirectional transport in axons. Unidirectional dendritic transport requires Eps15-homology-domain-containing (EHD) 1 and 3 protein function. Furthermore, loss of EHD function compromises dynamic axonal transport and overall BACE1 levels in axons. EHD1/3 colocalize with BACE1 and APP β-C-terminal fragments in hippocampal mossy fiber terminals, and their depletion in neurons significantly attenuates Aβ levels. These results demonstrate unidirectional endocytic transport of a dendritic cargo and reveal a role for EHD proteins in neuronal BACE1 transcytosis and Aβ production, processes that are highly relevant for Alzheimer’s disease