pinecone/core-2020-05-10-deduplication huggingface dataset:
Characteristics of patients with haematological and breast cancer (1996–2009) who died of heart failure-related causes after cancer therapy

Aims: To describe the characteristics and time to death of patients with breast or haematological cancer who died of heart failure (HF) after cancer therapy. Patients with an index admission for HF who died of HF-related causes (IAHF) and those with no index admission for HF who died of HF-related causes (NIAHF) were compared. Methods and results: We performed a linked data analysis of cancer registry, death registry, and hospital administration records (n = 15 987). Index HF admission must have occurred after cancer diagnosis. Of the 4894 patients who were deceased (30.6% of cohort), 734 died of HF-related causes (50.1% female) of which 279 (38.0%) had at least one IAHF (41.9% female) post-cancer diagnosis. Median age was 71 years [interquartile range (IQR) 62–78] for IAHF and 66 years (IQR 56–74) for NIAHF. There were fewer chemotherapy separations for IAHF patients (median = 4, IQR 2–9) compared with NIAHF patients (median = 6, IQR 2–12). Of the IAHF patients, 71% had died within 1 year of the index HF admission. There was no significant difference in HF-related mortality in IAHF patients compared with NIAHF (HR, 1.10, 95% CI, 0.94–1.29, P = 0.225). Conclusions: The profile of IAHF patients who died of HF-related causes after cancer treatment matched the current profile of HF in the general population (over half were aged ≥70 years). However, NIAHF were younger (62% were aged ≤69 years), female patients with breast cancer that died of HF-related causes before hospital admission for HF-related causes—a group that may have been undiagnosed or undertreated until death
Discovery of VHE emission towards the Carina arm region with the HESS telescope array: HESSJ1018-589

The Carina arm region, containing the supernova remnant SNR G284.3–1.8, the high-energy (HE; E > 100 MeV) binary 1FGL J1018.6–5856 and the energetic pulsar PSR J1016–5857 and its nebula, has been observed with the H.E.S.S. telescope array. The observational coverage of the region in very-high-energy (VHE; E > 0.1 TeV) γ-rays benefits from deep exposure (40 h) of the neighboring open cluster Westerlund 2. The observations have revealed a new extended region of VHE γ-ray emission. The new VHE source HESS J1018–589 shows a bright, point-like emission region positionally coincident with SNR G284.3–1.8 and 1FGL J1018.6–5856 and a diffuse extension towards the direction of PSR J1016–5857. A soft (Γ = 2.7 ± 0.5stat) photon index, with a differential flux at 1 TeV of N0 = (4.2 ± 1.1) × 10-13 TeV-1 cm-2 s-1 is found for the point-like source, whereas the total emission region including the diffuse emission region is well fit by a power-law function with spectral index Γ = 2.9 ± 0.4stat and differential flux at 1 TeV of N0 = (6.8 ± 1.6) × 10-13 TeV-1 cm-2 s-1. This H.E.S.S. detection motivated follow-up X-ray observations with the XMM-Newton satellite to investigate the origin of the VHE emission. The analysis of the XMM-Newton data resulted in the discovery of a bright, non-thermal point-like source (XMMU J101855.4–58564) with a photon index of Γ = 1.65 ± 0.08 in the center of SNR G284.3–1.8, and a thermal, extended emission region coincident with its bright northern filament. The characteristics of this thermal emission are used to estimate the plasma density in the region as n ≈ 0.5 cm-3 (2.9 kpc/d)2. The position of XMMU J101855.4–58564 is compatible with the position reported by the Fermi-LAT collaboration for the binary system 1FGL J1018.6–5856 and the variable Swift XRT source identified with it. The new X-ray data are used alongside archival multi-wavelength data to investigate the relationship between the VHE γ-ray emission from HESS J1018–589 and the various potential counterparts in the Carina arm region.Peer-reviewedPublisher Version11209
Parametric representation of open quantum systems and cross-over from quantum to classical environment.\ud

The behavior of most physical systems is affected by their natural surroundings. A quantum system with an environment is referred to as open, and its study varies according to the classical or quantum description adopted for the environment. We propose an approach to open quantum systems that allows us to follow the cross-over from quantum to classical environments; to achieve this, we devise an exact parametric representation of the principal system, based on generalized coherent states for the environment. The method is applied to the Graphic Heisenberg star with frustration, where the quantum character of the environment varies with the couplings entering the Hamiltonian H. We find that when the star is in an eigenstate of H, the central spin behaves as if it were in an effective magnetic field, pointing in the direction set by the environmental coherent-state angle variables Graphic, and broadened according to their quantum probability distribution. Such distribution is independent of φ, whereas as a function of θ is seen to get narrower as the quantum character of the environment is reduced, collapsing into a Dirac-δ function in the classical limit. In such limit, because φ is left undetermined, the Von Neumann entropy of the central spin remains finite; in fact, it is equal to the entanglement of the original fully quantum model, a result that establishes a relation between this latter quantity and the Berry phase characterizing the dynamics of the central spin in the effective magnetic field
Pseudodifferential operator calculus for generalized Q-rank 1 locally symmetric spaces, I.

This article was published in the Journal of Functional Analysis [© Elsevier Inc.]. It is published as an Open Archive article under an Elsevier User Licence, details are available at:http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseThis paper is the first of two papers constructing a calculus of pseudodifferential operators suitable for doing analysis on QQ-rank 1 locally symmetric spaces and Riemannian manifolds generalizing these. This generalization is the interior of a manifold with boundary, where the boundary has the structure of a tower of fibre bundles. The class of operators we consider on such a space includes those arising naturally from metrics which degenerate to various orders at the boundary, in directions given by the tower of fibrations. As well as QQ-rank 1 locally symmetric spaces, examples include Ricci-flat metrics on the complement of a divisor in a smooth variety constructed by Tian and Yau. In this first part of the calculus construction, parametrices are found for “fully elliptic differential a-operators,” which are uniformly elliptic operators on these manifolds that satisfy an additional invertibility condition at infinity. In the second part we will consider operators that do not satisfy this condition
Anti-phase synchronization and symmetry-breaking bifurcation of impulsively coupled oscillators.

This paper studies the synchronization in two mechanical oscillators coupled by impacts which can be considered as a class of state-dependent impulsively coupled oscillators. The two identical oscillators are harmonically excited in a counter phase, and the synchronous (anti-phase synchronization) and the asynchronous motions are considered. One- and two-parameter bifurcations of the system have been studied by varying the amplitude and the frequency of external excitation. Numerical simulations show that the system could exhibit complex phenomena, including symmetry and asymmetry periodic solutions, quasi-periodic solutions and chaotic solutions. In particular, the regimes in anti-phase synchronization are identified, and it is found that the symmetry-breaking bifurcation plays an important role in the transition from synchronous to asynchronous motion.National Natural Science Foundation of China (Grant nos. 11402224, 11202180, 61273106 and 11171290), the Natural Science Foundation of Jiangsu Province of China (Grant no. BK20151295), the Qin Lan Project of the Jiangsu Higher Education Institutions of China, and the Jiangsu Overseas Research and Training Program for University Prominent Young and Middle-aged Teachers and Presidents
Search for supersymmetry in events with soft leptons, low jet
  multiplicity, and missing transverse momentum in proton-proton collisions at
  sqrt(s) = 8 TeV

Results are presented from a search for supersymmetric particles in scenarios
with a compressed mass spectrum. The data sample corresponds to 19.7 inverse
femtobarns of proton-proton collisions recorded by the CMS experiment at
sqrt(s) = 8 TeV. The search targets top squark pair production in scenarios
with mass differences Delta m = m(top squark) - m(neutralino) below the W-boson
mass and with top-squark decays in the four-body mode (top squark to b l nu
neutralino), where the neutralino is assumed to be the lightest supersymmetric
particle (LSP). The signature includes a high transverse momentum (pt) jet
associated with initial-state radiation, one or two low-pt leptons, and
significant missing transverse energy. The event yields observed in data are
consistent with the expected background contributions from standard model
processes. Limits are set on the cross section for top squark pair production
as a function of the top squark and LSP masses. Assuming a 100% branching
fraction for the four-body decay mode, top-squark masses below 316 GeV are
excluded for Delta m = 25 GeV at 95% CL. The dilepton data are also interpreted
under the assumption of chargino-neutralino production, with subsequent decays
to sleptons or sneutrinos. Assuming a difference between the common lightest
chargino/next lightest neutralino mass and the LSP mass of 20 GeV and a
tau-enriched decay scenario, masses in the range m(chargino) < 307 GeV are
excluded at 95% CL.Comment: Replaced with published version. Added the journal reference and DOI.
  All figures and tables can be found at
  http://cms-results.web.cern.ch/cms-results/public-results/publications/SUS-14-021/index.htm
The role of flavon cross couplings in leptonic flavour mixing

In models with discrete flavour symmetries, flavons are critical to realise
specific flavour structures. Leptonic flavour mixing originates from the
misalignment of flavon vacuum expectation values which respect different
residual symmetries in the charged lepton and neutrino sectors. Flavon cross
couplings are usually forbidden, in order to protect these symmetries. Contrary
to this approach, we show that cross couplings can play a key role and give
raise to necessary corrections to flavour-mixing patterns, including a non-zero
value for the reactor angle and CP violation. For definiteness, we present two
models based on $A_4$. In the first model, all flavons are assumed to be real
or pseudo-real, with 7 real degrees of freedom in the flavon sector in total. A
sizable reactor angle associated with nearly maximal CP violation is achieved,
and, as both originate from the same cross coupling, a sum rule results with a
precise prediction for the value of the Dirac CP-violating phase. In the second
model, the flavons are taken to be complex scalars, which can be connected with
supersymmetric models and multi-Higgs models. The complexity properties of
flavons provide new sources for generating the reactor angle. Models in this
new approach introduce very few degrees of freedom beyond the Standard Model
and can be more economical than those in the framework of extra dimension or
supersymmetry.Comment: 21 pages, 3 figures, typo corrected, published in JHE
The two-loop electroweak bosonic corrections to $\sin^2\theta_{\rm
  eff}^{\rm b}$

The prediction of the effective electroweak mixing angle $\sin^2\theta_{\rm
eff}^{\rm b}$ in the Standard Model at two-loop accuracy has now been completed
by the first calculation of the bosonic two-loop corrections to the $Z{\bar
b}b$ vertex. Numerical predictions are presented in the form of a fitting
formula as function of $M_Z, M_W, M_H, m_t$ and $\Delta{\alpha}$, ${\alpha_{\rm
s}}$. For central input values, we obtain a relative correction of
$\Delta\kappa_{\rm b}^{(\alpha^2,\rm bos)} = -0.9855 \times 10^{-4}$, amounting
to about a quarter of the fermionic corrections, and corresponding to
$\sin^2\theta_{\rm eff}^{\rm b} = 0.232704$. The integration of the
corresponding two-loop vertex Feynman integrals with up to three dimensionless
parameters in Minkowskian kinematics has been performed with two approaches:
(i) Sector decomposition, implemented in the packages FIESTA 3 and SecDec 3,
and (ii) Mellin-Barnes representations, implemented in AMBRE 3/MB and the new
package MBnumerics.Comment: 14 pp; v2: some explanations and Tab.2 added, version published in
  PL
Prevalence of refractive error in Europe: the European Eye Epidemiology (E3) Consortium

To estimate the prevalence of refractive error in adults across Europe. Refractive data (mean spherical equivalent) collected between 1990 and 2013 from fifteen population-based cohort and cross-sectional studies of the European Eye Epidemiology (E3) Consortium were combined in a random effects meta-analysis stratified by 5-year age intervals and gender. Participants were excluded if they were identified as having had cataract surgery, retinal detachment, refractive surgery or other factors that might influence refraction. Estimates of refractive error prevalence were obtained including the following classifications: myopia ≤−0.75 diopters (D), high myopia ≤−6D, hyperopia ≥1D and astigmatism ≥1D. Meta-analysis of refractive error was performed for 61,946 individuals from fifteen studies with median age ranging from 44 to 81 and minimal ethnic variation (98 % European ancestry). The age-standardised prevalences (using the 2010 European Standard Population, limited to those ≥25 and <90 years old) were: myopia 30.6 % [95 % confidence interval (CI) 30.4–30.9], high myopia 2.7 % (95 % CI 2.69–2.73), hyperopia 25.2 % (95 % CI 25.0–25.4) and astigmatism 23.9 % (95 % CI 23.7–24.1). Age-specific estimates revealed a high prevalence of myopia in younger participants [47.2 % (CI 41.8–52.5) in 25–29 years-olds]. Refractive error affects just over a half of European adults. The greatest burden of refractive error is due to myopia, with high prevalence rates in young adults. Using the 2010 European population estimates, we estimate there are 227.2 million people with myopia across Europe
Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion
The novel μ-opioid receptor antagonist GSK1521498 decreases both alcohol seeking and drinking: evidence from a new preclinical model of alcohol seeking

Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction. To develop an effective translational animal model that illuminates this interaction, daily seeking responses, maintained by alcohol-associated conditioned stimuli (CSs), need to be dissociated from alcohol drinking behavior. For this, we established a procedure whereby alcohol seeking maintained by alcohol-associated CSs is followed by a period during which rats have the opportunity to drink alcohol. This cue-controlled alcohol-seeking procedure was used to compare the effects of naltrexone and GSK1521498, a novel selective μ-opioid receptor antagonist, on both voluntary alcohol-intake and alcohol-seeking behaviors. Rederived alcohol-preferring, alcohol-nonpreferring, and high-alcohol-drinking replicate 1 line of rats (Indiana University) first received 18 sessions of 24 h home cage access to 10% alcohol and water under a 2-bottle choice procedure. They were trained subsequently to respond instrumentally for access to 15% alcohol under a second-order schedule of reinforcement, in which a prolonged period of alcohol-seeking behavior was maintained by contingent presentations of an alcohol-associated CS acting as a conditioned reinforcer. This seeking period was terminated by 20 min of free alcohol drinking access that achieved significant blood alcohol concentrations. The influence of pretreatment with either naltrexone (0.1−1−3 mg/kg) or GSK1521498 (0.1–1–3 mg/kg) before instrumental sessions was measured on both seeking and drinking behaviors, as well as on drinking in the 2-bottle choice procedure. Naltrexone and GSK1521498 dose-dependently reduced both cue-controlled alcohol seeking and alcohol intake in the instrumental context as well as alcohol intake in the choice procedure. However, GSK1521498 showed significantly greater effectiveness than naltrexone, supporting its potential use for promoting abstinence and preventing relapse in alcohol addiction
Specific anchoring modes of two distinct dystrophin rod sub-domains interacting in phospholipid Langmuir films studied by atomic force microscopy and PM-IRRAS.

International audienceDystrophin rod repeats 1-3 sub-domain binds to acidic phosphatidylserine in a small vesicle binding assay, while the repeats 20-24 sub-domain does not. In the present work, we studied the adsorption behaviour of both sub-domains at the air/liquid interface and at the air/lipid interface in a Langmuir trough in order to highlight differences in interfacial properties. The adsorption behaviour of the two proteins at the air/liquid interface shows that they display surface activity while maintaining their alpha-helical secondary structure as shown by PM-IRRAS. Strikingly, R20-24 needs to be highly hydrated even at the interface, while this is not the case for R1-3, indicating that the surface activity is dramatically higher for R1-3 than R20-24. Surface-pressure measurements, atomic force microscopy and PM-IRRAS are used in a Langmuir experiment with DOPC-DOPS monolayers at two different surface pressures, 20mN/m and 30mN/m. At the lower surface pressure, the proteins are adsorbed at the lipid film interface while maintaining its alpha-helical structure. After an increase of the surface pressure, R1-3 subsequently produces a stable film, while R20-24 induces a reorganization of the lipid film with a subsequent decrease of the surface pressure close to the initial value. AFM and PM-IRRAS show that R1-3 is present in high amounts at the interface, being arranged in clusters representing 3.3% of the surface at low pressure. By contrast, R20-24 is present at the interface in small amounts bound only by a few electrostatic residues to the lipid film while the major part of the molecule remains floating in the sub-phase. Then for R1-3, the electrostatic interaction between the proteins and the film is enhanced by hydrophobic interactions. At higher surface pressure, the number of protein clusters increases and becomes closer in both cases implying the electrostatic character of the binding. These results indicate that even if the repeats exhibit large structural similarities, their interfacial properties are highly contrasted by their differential anchor mode in the membrane. Our work provides strong support for distinct physiological roles for the spectrin-like repeats and may partly explain the effects of therapeutic replacement of dystrophin deficiency by minidystrophins
Planck Intermediate Results II: Comparison of Sunyaev-Zeldovich
  measurements from Planck and from the Arcminute Microkelvin Imager for 11
  galaxy clusters

A comparison is presented of Sunyaev-Zeldovich measurements for 11 galaxy
clusters as obtained by Planck and by the ground-based interferometer, the
Arcminute Microkelvin Imager. Assuming a universal spherically-symmetric
Generalised Navarro, Frenk & White (GNFW) model for the cluster gas pressure
profile, we jointly constrain the integrated Compton-Y parameter (Y_500) and
the scale radius (theta_500) of each cluster. Our resulting constraints in the
Y_500-theta_500 2D parameter space derived from the two instruments overlap
significantly for eight of the clusters, although, overall, there is a tendency
for AMI to find the Sunyaev-Zeldovich signal to be smaller in angular size and
fainter than Planck. Significant discrepancies exist for the three remaining
clusters in the sample, namely A1413, A1914, and the newly-discovered Planck
cluster PLCKESZ G139.59+24.18. The robustness of the analysis of both the
Planck and AMI data is demonstrated through the use of detailed simulations,
which also discount confusion from residual point (radio) sources and from
diffuse astrophysical foregrounds as possible explanations for the
discrepancies found. For a subset of our cluster sample, we have investigated
the dependence of our results on the assumed pressure profile by repeating the
analysis adopting the best-fitting GNFW profile shape which best matches X-ray
observations. Adopting the best-fitting profile shape from the X-ray data does
not, in general, resolve the discrepancies found in this subset of five
clusters. Though based on a small sample, our results suggest that the adopted
GNFW model may not be sufficiently flexible to describe clusters universally.Comment: update to metadata author list onl
AdS6 solutions of type II supergravity

Very few AdS6 × M 4 supersymmetric solutions are known: one in massive IIA, and two IIB solutions dual to it. The IIA solution is known to be unique; in this paper, we use the pure spinor approach to give a classification for IIB supergravity. We reduce the problem to two PDEs on a two-dimensional space Σ. M 4 is then a fibration of S 2 over Σ; the metric and fluxes are completely determined in terms of the solution to the PDEs. The results seem likely to accommodate near-horizon limits of (p, q)-fivebrane webs studied in the literature as a source of CFT5’s. We also show that there are no AdS6 solutions in eleven-dimensional supergravity
On Robust Solutions to Linear Least Squares Problems Affected by Data Uncertainty and Implementation Errors with Aplication to Stochastic Signal Modeling

Cataloged from PDF version of article.Engineering design problems, especially in signal and image processing, give rise to linear
least squares problems arising from discretization of some inverse problem. The associated
data are typically subject to error in these applications while the computed solution may only
be implemented up to limited accuracy digits, i.e., quantized. In the present paper, we advocate
the use of the robust counterpart approach of Ben-Tal and Nemirovski to address these
issues simultaneously. Approximate robust counterpart problems are derived, which leads to
semidefinite programming problems yielding stable solutions to overdetermined systems of
linear equations affected by both data uncertainty and implementation errors, as evidenced by
numerical examples from stochastic signal modeling.
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