pinecone/core-2020-05-10-deduplication huggingface dataset:
Expression of transient receptor potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart

AbstractThe atrial volume receptor reflex arc serves to regulate plasma volume. Atrial volume receptors located in the endocardium of the atrial wall undergo mechanical deformation as blood is returned to the atria of the heart. The mechanosensitive channel(s) responsible for regulating plasma volume remain to be determined. Here we report that the TRP channel family members TRPC1 and TRPV4 were expressed in sensory nerve endings in the atrial endocardium. Furthermore, TRPC1 and TRPV4 were coincident with the nerve ending vesicle marker synaptophysin. Calcitonin gene-related peptide was exclusively confined to the myo- and epicardium of the atria. The small conductance Ca2+-activated K+ channels (SK2 and SK4) were also present, however there was no relationship between SK and TRP channels. SK2 channels were expressed in nerves in the epicardium, while SK4 channels were in some regions of the endocardium but appeared to be present in epithelial cells rather than sensory endings. In conclusion, we have provided the first evidence for TRPC1 and TRPV4 channels as potential contributors to mechanosensation in the atrial volume receptors
Search for high mass dilepton resonances in pp collisions at s=7 TeV with the ATLAS experiment

AbstractThis Letter presents a search for high mass e+e− or μ+μ− resonances in pp collisions at s=7 TeV at the LHC. The data were recorded by the ATLAS experiment during 2010 and correspond to a total integrated luminosity of ∼40 pb−1. No statistically significant excess above the Standard Model expectation is observed in the search region of dilepton invariant mass above 110 GeV. Upper limits at the 95% confidence level are set on the cross section times branching ratio of Z′ resonances decaying to dielectrons and dimuons as a function of the resonance mass. A lower mass limit of 1.048 TeV on the Sequential Standard Model Z′ boson is derived, as well as mass limits on Z⁎ and E6-motivated Z′ models
Stable chromium isotopic composition of meteorites and metal–silicate experiments: Implications for fractionation during core formation

AbstractWe present new mass independent and mass dependent Cr isotope compositions for meteorites measured by double spike thermal ionisation mass spectrometry. Small differences in both mass independent 53Cr and 54Cr relative to the Bulk Silicate Earth are reported and are very similar to previously published values. Carbonaceous chondrites are characterised by an excess in 54Cr compared to ordinary and enstatite chondrites which make mass independent Cr isotopes a useful tool for distinguishing between meteoritic groups. Mass dependent stable Cr isotope compositions for the same samples are also reported. Carbonaceous and ordinary chondrites are identical within uncertainty with average δ53Cr values of −0.118±0.040‰ and −0.143±0.074‰ respectively. The heaviest isotope compositions are recorded by an enstatite chondrite and a CO carbonaceous chondrite, both of which have relatively reduced chemical compositions implying some stable Cr isotope fractionation related to redox processes in the circumstellar disk. The average δ53Cr values for chondrites are within error of the estimate for the Bulk Silicate Earth (BSE) also determined by double spiking. The lack of isotopic difference between chondritic material and the BSE provides evidence that Cr isotopes were not fractionated during core formation on Earth. A series of high-pressure experiments was also carried out to investigate stable Cr isotope fractionation between metal and silicate and no demonstrable fractionation was observed, consistent with our meteorites data. Mass dependent Cr isotope data for achondrites suggest that Cr isotopes are fractionated during magmatic differentiation and therefore further work is required to constrain the Cr isotopic compositions of the mantles of Vesta and Mars
You have e-mail, what happens next? Tracking the eyes for genre

AbstractThis paper reports on an approach to the analysis of form (layout and formatting) during genre recognition recorded using eye tracking. The researchers focused on eight different types of e-mail, such as calls for papers, newsletters and spam, which were chosen to represent different genres. The study involved the collection of oculographic behavior data based on the scanpath duration and scanpath length based metric, to highlight the ways in which people view the features of genres. We found that genre analysis based on purpose and form (layout features, etc.) was an effective means of identifying the characteristics of these e-mails.The research, carried out on a group of 24 participants, highlighted their interaction and interpretation of the e-mail texts and the visual cues or features perceived. In addition, the ocular strategies of scanning and skimming, they employed for the processing of the texts by block, genre and representation were evaluated
Nuclear shadowing in neutrino–nucleus deeply inelastic scattering

AbstractIn the framework of the collinear factorized pQCD approach we calculate the small-xB process-dependent nuclear modification to the structure functions measured in neutrino–nucleus deeply inelastic scattering. We include both heavy quark mass corrections (M2/Q2) and resummed nuclear-enhanced dynamical power corrections in the quantity (ξ2/Q2)(A1/3−1) with ξ2 evaluated to leading order in αs. Our formalism predicts a measurable difference in the shadowing pattern of the structure functions F2A(xB,Q2) and F3A(xB,Q2) and a significant low- and moderate-Q2 modification of the QCD sum rules. We also comment on the relevance of our results to the NuTeV extraction of sin2θW
Caenorhabditis elegans HUS-1 Is a DNA Damage Checkpoint Protein Required for Genome Stability and EGL-1-Mediated Apoptosis

AbstractBackground: The inability to efficiently repair DNA damage or remove cells with severely damaged genomes has been linked to several human cancers. Studies in yeasts and mammals have identified several genes that are required for proper activation of cell cycle checkpoints following various types of DNA damage. However, in metazoans, DNA damage can induce apoptosis as well. How DNA damage activates the apoptotic machinery is not fully understood.Results: We demonstrate here that the Caenorhabditis elegans gene hus-1 is required for DNA damage-induced cell cycle arrest and apoptosis. Following DNA damage, HUS-1 relocalizes and forms distinct foci that overlap with chromatin. Relocalization does not require the novel checkpoint protein RAD-5; rather, relocalization appears more frequently in rad-5 mutants, suggesting that RAD-5 plays a role in repair. HUS-1 is required for genome stability, as demonstrated by increased frequency of spontaneous mutations, chromosome nondisjunction, and telomere shortening. Finally, we show that DNA damage increases expression of the proapoptotic gene egl-1, a response that requires hus-1 and the p53 homolog cep-1.Conclusions: Our findings suggest that the RAD-5 checkpoint protein is not required for HUS-1 to relocalize following DNA damage. Furthermore, our studies reveal a new function of HUS-1 in the prevention of telomere shortening and mortalization of germ cells. DNA damage-induced germ cell death is abrogated in hus-1 mutants, in part, due to the inability of these mutants to activate egl-1 transcription in a cep-1/p53-dependent manner. Thus, HUS-1 is required for p53-dependent activation of a BH3 domain protein in C. elegans
The riddle of polarization in B→VV transitions

AbstractMeasurements of polarization fractions in B→VV transitions, with V a light vector meson, show that the longitudinal amplitude dominates in B0→ρ+ρ−, B+→ρ+ρ0, and B+→ρ0K*+ decays and not in the penguin induced decays B0→ϕK*0, B+→ϕK*+. We study the effect of rescattering mediated by charmed resonances, finding that in B→ϕK* it can be responsible of the suppression of the longitudinal amplitude. For the decay B→ρK* we find that the longitudinal fraction cannot be too large without invoking new effects
Changing climate and nutrient transfers: Evidence from high temporal resolution concentration-flow dynamics in headwater catchments

AbstractWe hypothesise that climate change, together with intensive agricultural systems, will increase the transfer of pollutants from land to water and impact on stream health. This study builds, for the first time, an integrated assessment of nutrient transfers, bringing together a) high-frequency data from the outlets of two surface water-dominated, headwater (~10km2) agricultural catchments, b) event-by-event analysis of nutrient transfers, c) concentration duration curves for comparison with EU Water Framework Directive water quality targets, d) event analysis of location-specific, sub-daily rainfall projections (UKCP, 2009), and e) a linear model relating storm rainfall to phosphorus load. These components, in combination, bring innovation and new insight into the estimation of future phosphorus transfers, which was not available from individual components. The data demonstrated two features of particular concern for climate change impacts. Firstly, the bulk of the suspended sediment and total phosphorus (TP) load (greater than 90% and 80% respectively) was transferred during the highest discharge events. The linear model of rainfall-driven TP transfers estimated that, with the projected increase in winter rainfall (+8% to +17% in the catchments by 2050s), annual event loads might increase by around 9% on average, if agricultural practices remain unchanged. Secondly, events following dry periods of several weeks, particularly in summer, were responsible for high concentrations of phosphorus, but relatively low loads. The high concentrations, associated with low flow, could become more frequent or last longer in the future, with a corresponding increase in the length of time that threshold concentrations (e.g. for water quality status) are exceeded. The results suggest that in order to build resilience in stream health and help mitigate potential increases in diffuse agricultural water pollution due to climate change, land management practices should target controllable risk factors, such as soil nutrient status, soil condition and crop cover
Phase transitions for the topological de Sitter spaces and Schwarzschild–de Sitter black hole

AbstractWe study whether the Hawking–Page phase transition may occur in topological de Sitter spaces (TdS) and Schwarzschild–de Sitter black hole (SdS). We show that at the critical temperature T=T1, TdS with hyperbolic cosmological horizon can make the Hawking–Page transition from the zero mass de Sitter space to TdS. It is also shown that there is no Hawking–Page transition for TdS with Ricci-flat and spherical horizons, when the zero mass de Sitter space is taken as the thermal background. Also we find that the SdS undergoes a different phase transition at T=0 which the Nariai black hole is formed. Finally we connect our results to the dS/CFT correspondence
Geometric ergodicity of a bead–spring pair with stochastic Stokes forcing

AbstractWe consider a simple model for the fluctuating hydrodynamics of a flexible polymer in a dilute solution, demonstrating geometric ergodicity for a pair of particles that interact with each other through a nonlinear spring potential while being advected by a stochastic Stokes fluid velocity field. This is a generalization of previous models which have used linear spring forces as well as white-in-time fluid velocity fields.We follow previous work combining control theoretic arguments, Lyapunov functions, and hypo-elliptic diffusion theory to prove exponential convergence via a Harris chain argument. In addition we allow the possibility of excluding certain “bad” sets in phase space in which the assumptions are violated but from which the system leaves with a controllable probability. This allows for the treatment of singular drifts, such as those derived from the Lennard-Jones potential, which is a novel feature of this work
Universally finite gravitational and gauge theories

AbstractIt is well known that standard gauge theories are renormalizable in D=4 while Einstein gravity is renormalizable in D=2. This is where the research in the field of two derivatives theories is currently standing. We hereby present a class of weakly non-local higher derivative gravitational and gauge theories universally consistent at quantum level in any spacetime dimension. These theories are unitary (ghost-free) and perturbatively renormalizable. Moreover, we can always find a simple extension of these theories that is super-renormalizable or finite at quantum level in even and odd spacetime dimensions. Finally, we propose a super-renormalizable or finite theory for gravity coupled to matter laying the groundwork for a “finite standard model of particle physics” and/or a grand unified theory of all fundamental interactions
Wellbeing in the aftermath of floods

AbstractThe interactions between flood events, their aftermath, and recovery leading to health and wellbeing outcomes for individuals are complex, and the pathways and mechanisms through which wellbeing is affected are often hidden and remain under-researched. This study analyses the diverse processes that explain changes in wellbeing for those experiencing flooding. It identifies key pathways to wellbeing outcomes that concern perceptions of lack of agency, dislocation from home, and disrupted futures inducing negative impacts, with offsetting positive effects through community networks and interactions. The mixed method study is based on data from repeated qualitative semi-structured interviews (n=60) and a structured survey (n=1000) with individuals that experienced flooding directly during winter 2013/14 in two UK regions. The results show for the first time the diversity and intersection of pathways to wellbeing outcomes in the aftermath of floods. The findings suggest that enhanced public health planning and interventions could focus on the precise practices and mechanisms that intersect to produce anxiety, stress, and their amelioration at individual and community levels
Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs

SummaryDefects in articular cartilage ultimately result in loss of joint function. Repairing cartilage defects requires cell sources. We developed an approach to generate scaffoldless hyaline cartilage from human induced pluripotent stem cells (hiPSCs). We initially generated an hiPSC line that specifically expressed GFP in cartilage when teratoma was formed. We optimized the culture conditions and found BMP2, transforming growth factor β1 (TGF-β1), and GDF5 critical for GFP expression and thus chondrogenic differentiation of the hiPSCs. The subsequent use of scaffoldless suspension culture contributed to purification, producing homogenous cartilaginous particles. Subcutaneous transplantation of the hiPSC-derived particles generated hyaline cartilage that expressed type II collagen, but not type I collagen, in immunodeficiency mice. Transplantation of the particles into joint surface defects in immunodeficiency rats and immunosuppressed mini-pigs indicated that neocartilage survived and had potential for integration into native cartilage. The immunodeficiency mice and rats suffered from neither tumors nor ectopic tissue formation. The hiPSC-derived cartilaginous particles constitute a viable cell source for regenerating cartilage defects
The spectrum of Ds mesons from lattice QCD

AbstractThe spectrum of orbitally excited Ds mesons is computed in the continuum limit of quenched lattice QCD. The results are consistent with the interpretation that the narrow resonance in the Dsπ0 channel discovered by the BaBar Collaboration is a JP=0+ cs̄ meson. Furthermore, within statistical errors, the 1+–1− and the 0+–0− mass splittings are equal, in agreement with the chiral multiplet structure predicted by heavy hadron chiral effective theory. On our coarsest lattice we present results from the first study of orbitally excited Ds mesons with two flavors of dynamical quarks, with mass slightly larger than the strange quark mass. These results are consistent with the quenched data
Measurement of electrons from beauty hadron decays in pp collisions at s=7 TeV

AbstractThe production cross section of electrons from semileptonic decays of beauty hadrons was measured at mid-rapidity (|y|<0.8) in the transverse momentum range 1<pT<8 GeV/c with the ALICE experiment at the CERN LHC in pp collisions at a center of mass energy s=7 TeV using an integrated luminosity of 2.2 nb−1. Electrons from beauty hadron decays were selected based on the displacement of the decay vertex from the collision vertex. A perturbative QCD calculation agrees with the measurement within uncertainties. The data were extrapolated to the full phase space to determine the total cross section for the production of beauty quark–antiquark pairs
Separability and Killing tensors in Kerr–Taub-NUT–de Sitter metrics in higher dimensions

AbstractA generalisation of the four-dimensional Kerr–de Sitter metrics to include a NUT charge is well known, and is included within a class of metrics obtained by Plebanski. In this Letter, we study a related class of Kerr–Taub-NUT–de Sitter metrics in arbitrary dimensions D⩾6, which contain three non-trivial continuous parameters, namely the mass, the NUT charge, and a (single) angular momentum. We demonstrate the separability of the Hamilton–Jacobi and wave equations, we construct a closely-related rank-2 Stäckel–Killing tensor, and we show how the metrics can be written in a double Kerr–Schild form. Our results encompass the case of the Kerr–de Sitter metrics in arbitrary dimension, with all but one rotation parameter vanishing. Finally, we consider the real Euclidean-signature continuations of the metrics, and show how in a limit they give rise to certain recently-obtained complete non-singular compact Einstein manifolds
Genome sequences of six Phytophthora species associated with forests in New Zealand

AbstractIn New Zealand there has been a long association of Phytophthora diseases in forests, nurseries, remnant plantings and horticultural crops. However, new Phytophthora diseases of trees have recently emerged. Genome sequencing has been performed for 12 Phytophthora isolates, from six species: Phytophthora pluvialis, Phytophthora kernoviae, Phytophthora cinnamomi, Phytophthora agathidicida, Phytophthora multivora and Phytophthora taxon Totara. These sequences will enable comparative analyses to identify potential virulence strategies and ultimately facilitate better control strategies. This Whole Genome Shotgun data have been deposited in DDBJ/ENA/GenBank under the accession numbers LGTT00000000, LGTU00000000, JPWV00000000, JPWU00000000, LGSK00000000, LGSJ00000000, LGTR00000000, LGTS00000000, LGSM00000000, LGSL00000000, LGSO00000000, and LGSN00000000
Structure–activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S

AbstractA new series of organotelluranes were synthesized and investigated, and the structure–activity relationships in cysteine proteases inhibition were determinated. It was possible to identify the relevance of structural components linked to the reactivity of these compounds as inhibitors. For example, dibromo-organotelluranes showed to be more reactive than dichloro-organotelluranes towards cysteine cathepsins V and S. Besides, no remarkable enantio-selectivity was verified. In general the achiral organotelluranes were more reactive than the chiral congeners against cysteine cathepsins V and S. A reactivity order for organochalcogenanes and cysteine cathepsins was proposed after the comparison of the inhibitory potencies of organotelluranes with the related organoselenanes
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents

AbstractCurrent drugs against human African trypanosomiasis (HAT) suffer from several serious drawbacks. The search for novel, effective, brain permeable, safe, and inexpensive antitrypanosomal compounds is therefore an urgent need. We have recently reported that the 4-aminoquinoline derivative huprine Y, developed in our group as an anticholinesterasic agent, exhibits a submicromolar potency against Trypanosoma brucei and that its homo- and hetero-dimerization can result in to up to three-fold increased potency and selectivity. As an alternative strategy towards more potent smaller molecule anti-HAT agents, we have explored the introduction of ω-cyanoalkyl, ω-aminoalkyl, or ω-guanidinoalkyl chains at the primary amino group of huprine or the simplified 4-aminoquinoline analogue tacrine. Here, we describe the evaluation of a small in-house library and a second generation of newly synthesized derivatives, which has led to the identification of 13 side chain modified 4-aminoquinoline derivatives with submicromolar potencies against T. brucei. Among these compounds, the guanidinononyltacrine analogue 15e exhibits a 5-fold increased antitrypanosomal potency, 10-fold increased selectivity, and 100-fold decreased anticholinesterasic activity relative to the parent huprine Y. Its biological profile, lower molecular weight relative to dimeric compounds, reduced lipophilicity, and ease of synthesis, make it an interesting anti-HAT lead, amenable to further optimization to eliminate its remaining anticholinesterasic activity
Depressed mantle discontinuities beneath Iceland: Evidence of a garnet controlled 660 km discontinuity?

AbstractThe presence of a mantle plume beneath Iceland has long been hypothesised to explain its high volumes of crustal volcanism. Practical constraints in seismic tomography mean that thin, slow velocity anomalies representative of a mantle plume signature are difficult to image. However it is possible to infer the presence of temperature anomalies at depth from the effect they have on phase transitions in surrounding mantle material. Phase changes in the olivine component of mantle rocks are thought to be responsible for global mantle seismic discontinuities at 410 and 660 km depth, though exact depths are dependent on surrounding temperature conditions. This study uses P to S seismic wave conversions at mantle discontinuities to investigate variation in topography allowing inference of temperature anomalies within the transition zone. We employ a large data set from a wide range of seismic stations across the North Atlantic region and a dense network in Iceland, including over 100 stations run by the University of Cambridge. Data are used to create over 6000 receiver functions. These are converted from time to depth including 3D corrections for variations in crustal thickness and upper mantle velocity heterogeneities, and then stacked based on common conversion points. We find that both the 410 and 660 km discontinuities are depressed under Iceland compared to normal depths in the surrounding region. The depression of 30 km observed on the 410 km discontinuity could be artificially deepened by un-modelled slow anomalies in the correcting velocity model. Adding a slow velocity conduit of −1.44% reduces the depression to 18 km; in this scenario both the velocity reduction and discontinuity topography reflect a temperature anomaly of 210 K. We find that much larger velocity reductions would be required to remove all depression on the 660 km discontinuity, and therefore correlated discontinuity depressions appear to be a robust feature of the data. While it is not possible to definitively rule out the possibility of uncorrected velocity anomalies causing the observed correlated topography we show that this is unlikely. Instead our preferred interpretation is that the 660 km discontinuity is controlled by a garnet phase transition described by a positive Clapeyron slope, such that depression of the 660 is representative of a hot anomaly at depth