pinecone/core-2020-05-10-deduplication huggingface dataset:
Centrality dependence of inclusive J/$\psi$ production in p-Pb
  collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV

We present a measurement of inclusive J/$\psi$ production in p-Pb collisions
at $\sqrt{s_{\rm NN}}$ = 5.02 TeV as a function of the centrality of the
collision, as estimated from the energy deposited in the Zero Degree
Calorimeters. The measurement is performed with the ALICE detector down to zero
transverse momentum, $p_{\rm T}$, in the backward ($-4.46 < y_{\rm cms} <
-2.96$) and forward ($2.03 < y_{\rm cms} < 3.53$) rapidity intervals in the
dimuon decay channel and in the mid-rapidity region ($-1.37 < y_{\rm cms} <
0.43$) in the dielectron decay channel. The backward and forward rapidity
intervals correspond to the Pb-going and p-going direction, respectively. The
$p_{\rm T}$-differential J/$\psi$ production cross section at backward and
forward rapidity is measured for several centrality classes, together with the
corresponding average $p_{\rm T}$ and $p^2_{\rm T}$ values. The nuclear
modification factor, $Q_{\rm pPb}$, is presented as a function of centrality
for the three rapidity intervals, and, additionally, at backward and forward
rapidity, as a function of $p_{\rm T}$ for several centrality classes. At mid-
and forward rapidity, the J/$\psi$ yield is suppressed up to 40% compared to
that in pp interactions scaled by the number of binary collisions. The degree
of suppression increases towards central p-Pb collisions at forward rapidity,
and with decreasing $p_{\rm T}$ of the J/$\psi$. At backward rapidity, the
$Q_{\rm pPb}$ is compatible with unity within the total uncertainties, with an
increasing trend from peripheral to central p-Pb collisions.Comment: 29 pages, 6 captioned figures, 4 tables, authors from page 23,
  published version, figures at
  http://aliceinfo.cern.ch/ArtSubmission/node/168
Laser irradiation-induced alpha to delta phase transformation in Bi_2O_3 ceramics and nanowires

The α-Bi_2O_3 to σ- Bi_2O_3  phase transformation has been locally induced by laser irradiation in ceramic samples and single-crystal nanowires of this oxide. The threshold power densities necessary to induce this transformation, as well as the corresponding transformation kinetics and its temporal stability, have been investigated in both kinds of samples by micro-Raman spectroscopy. The appearance of the delta phase was also monitored by spatially resolved photoluminescence spectroscopy. An emission band peaked near 1.67 eV, not observed in α-Bi_2O_3, is tentatively attributed to to σ- Bi_2O_3  near band gap transitions
Breaks in thin and thick disks of edge-on galaxies imaged in the Spitzer survey of stellar structure in galaxies (S^4G)

Breaks in the radial luminosity profiles of galaxies have until now been mostly studied averaged over disks. Here, we study separately breaks in thin and thick disks in 70 edge-on galaxies using imaging from the Spitzer Survey of Stellar Structure in Galaxies. We built luminosity profiles of the thin and thick disks parallel to midplanes and we found that thin disks often truncate (77%). Thick disks truncate less often (31%), but when they do, their break radius is comparable with that in the thin disk. This suggests either two different truncation mechanisms—one of dynamical origin affecting both disks simultaneously and another one only affecting the thin disk—or a single mechanism that creates a truncation in one disk or in both depending on some galaxy property. Thin disks apparently antitruncate in around 40% of galaxies. However, in many cases, these antitruncations are an artifact caused by the superposition of a thin disk and a thick disk, with the latter having a longer scale length. We estimate the real thin disk antitruncation fraction to be less than 15%. We found that the ratio of the thick and thin stellar disk mass is roughly constant (0.2 < M_T /M_t < 0.7) for circular velocities ν_c > 120 km s^–1, but becomes much larger at smaller velocities. We hypothesize that this is due to a combination of a high efficiency of supernova feedback and a slower dynamical evolution in lower-mass galaxies causing stellar thin disks to be younger and less massive than in higher-mass galaxies
Extensive MIS 3 glaciation in southernmost Patagonia revealed by cosmogenic nuclide dating of outwash sediments

The timing and extent of former glacial advances can demonstrate leads and lags during periods of climatic change and their forcing, but this requires robust glacial chronologies. In parts of southernmost Patagonia, dating pre-global Last Glacial Maximum (gLGM) ice limits has proven difficult due to post-deposition processes affecting the build-up of cosmogenic nuclides in moraine boulders. Here we provide ages for the Río Cullen and San Sebastián glacial limits of the former Bahía Inútil–San Sebastián (BI-SSb) ice lobe on Tierra del Fuego (53–54°S), previously hypothesised to represent advances during Marine Isotope Stages (MIS) 12 and 10, respectively. Our approach uses cosmogenic 10Be and 26Al exposure dating, but targets glacial outwash associated with these limits and uses depth-profiles and surface cobble samples, thereby accounting for surface deflation and inheritance. The data reveal that the limits formed more recently than previously thought, giving ages of 45.6 ka for the Río Cullen, and 30.1 ka for the San Sebastián limits. These dates indicate extensive glaciation in southern Patagonia during MIS 3, prior to the well-constrained, but much less extensive MIS 2 (gLGM) limit. This suggests the pattern of ice advances in the region was different to northern Patagonia, with the terrestrial limits relating to the last glacial cycle, rather than progressively less extensive glaciations over hundreds of thousands of years. However, the dates are consistent with MIS 3 glaciation elsewhere in the southern mid-latitudes, and the combination of cooler summers and warmer winters with increased precipitation, may have caused extensive glaciation prior to the gLGM.\u
ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD<sup>+</sup>depletion

© 2014 The Authors. ARTD1 (PARP1) is a key enzyme involved in DNA repair through the synthesis of poly(ADP-ribose) (PAR) in response to strand breaks, and it plays an important role in cell death following excessive DNA damage. ARTD1-induced cell death is associated with NAD+depletion and ATP loss; however, the molecular mechanism of ARTD1-mediated energy collapse remains elusive. Using real-time metabolic measurements, we compared the effects of ARTD1 activation and direct NAD+depletion. We found that ARTD1-mediated PAR synthesis, but not direct NAD+depletion, resulted in a block to glycolysis and ATP loss. We then established a proteomics-based PAR interactome after DNA damage and identified hexokinase 1 (HK1) as a PAR binding protein. HK1 activity is suppressed following nuclear ARTD1 activation and binding by PAR. These findings help explain how prolonged activation of ARTD1 triggers energy collapse and cell death, revealing insight into the importance of nucleus-to-mitochondria communication via ARTD1 activation
Study of $\Upsilon$ production and cold nuclear matter effects in pPb collisions at $\sqrt{s_{NN}}=5~\mathrm{TeV}$

Production of $\Upsilon$ mesons in proton-lead collisions at a nucleon-nucleon centre-of-mass energy $\sqrt{s_{NN}}=5 \mathrm{TeV}$ is studied with the LHCb detector. The analysis is based on a data sample corresponding to an integrated luminosity of $1.6 \mathrm{nb}^{-1}$. The $\Upsilon$ mesons of transverse momenta up to $15 \mathrm{GeV}/c$ are reconstructed in the dimuon decay mode. The rapidity coverage in the centre-of-mass system is $1.5<y<$4.0 (forward region) and $-5.0<y<$-2.5 (backward region). The forward-backward production ratio and the nuclear modification factor for $\Upsilon(1S)$ mesons are determined. The data are compatible with the predictions for a suppression of $\Upsilon(1S)$ production with respect to proton-proton collisions in the forward region, and an enhancement in the backward region. The suppression is found to be smaller than in the case of prompt $J/\psi$ mesons
The physiological user’s response as a clue to assess visual variables effectiveness

The paper deals with the introduction of Bertin’s visual variables in an ATC context. The ranking of the efficiency of these variables has been experimentally verified by Cleveland, however, no studies highlight the physiological correlates of this ranking. We analyzed behavioral, physiological and subjective data recorded on 7 healthy subjects facing a visual comparison task witch involve 5 selected visual characterizations (angle, text, surface, framed rectangles and luminosity). Results showed that the observed accuracy was coherent with Mackinlay ranking of visual variables. Psychophysiological and subjective\ud
measurements are also discussed
N270 sensitivity to conﬂict strength and working memory: a combined ERP and sLORETA study

The event-related potential N270 component is known to be an electrophysiological marker of the supramodal\ud
conﬂict processing. However little is know about the factors that may modulate its amplitude. In particular, among all studies that have investigated the N270, little or no control of the conﬂict strength and of the load in working memory have been done leaving a lack in the understanding of this component. We designed a spatial audiovisual conﬂict task with simultaneous target and cross-modal distractor to evaluate the N270 sensitivity to the conﬂict strength (i.e.,visual target with auditory distractor or auditory target with visual distractor) and the load in working memory (goal task maintenance with frequent change in the target modality). In a ﬁrst session, participants had to focus on one modality for the target position to be considered (left-hand or right-hand) while the distractor could be at the same side (compatible) or at opposite side (incompatible). In a second session, we used the same set of stimuli as in the ﬁrst session with an additional distinct auditory signal that clued the participants to frequently switch between the\ud
auditory and the visual targets. We found that (1) reaction times and N270 amplitudes for conﬂicting situations were\ud
larger within the auditory target condition compared to the visual one, (2) the increase in target maintenance e ﬀ ort led to equivalent increase of both reaction times and N270 amplitudes within all conditions and (3) the right dorsolateral prefrontal cortex current density was higher for both conﬂicting and active maintenance of the target situations. These results provide new evidence that the N270 component is an electrophysiological marker of the supramodal conﬂict processing that is sensitive to the conﬂict strength and that conﬂict processing and active maintenance of the task goal are two functions of a common executive attention system
Collapse of the low temperature insulating state in Cr-doped V2O3 thin films

We have grown epitaxial Cr-doped V2O3 thin films with Cr concentrations between 0% and 20% on (0001)-Al2O3 by oxygen-assisted molecular beam epitaxy. For the highly doped samples (>3%), a regular and monotonous increase of the resistance with decreasing temperature is measured. Strikingly, in the low doping samples (between 1% and 3%), a collapse of the insulating state is observed with a reduction of the low temperature resistivity by up to 5 orders of magnitude. A vacuum annealing at high temperature of the films recovers the low temperature insulating state for doping levels below 3% and increases the room temperature resistivity towards the values of Cr-doped V2O3 single crystals. It is well-know that oxygen excess stabilizes a metallic state in V2O3 single crystals. Hence, we propose that Cr doping promotes oxygen excess in our films during deposition, leading to the collapse of the low temperature insulating state at low Cr concentrations. These results suggest that slightly Cr-doped V2O3 films can be interesting candidates for field effect devices.status: publishe
On the oscillation of species

We describe a new class of BPS objects called magnetubes: their supersymmetry is determined by their magnetic charges, while their electric charges can oscillate freely between different species. We show how to incorporate these objects into microstate geometries and create BPS solutions in which the charge densities rotate through different U(1) species as one moves around a circle within the microstate geometry. Our solutions have the same “time-like” supersymmetry as five-dimensional, three-charge black holes but, in various parts of the solution, the supersymmetry takes the “null” form that is normally associated with magnetic charges. It is this property that enables the species oscillation of magnetubes to be compatible with supersymmetry. We give an example in which the species oscillate non-trivially around a circle within a microstate geometry, and yet the energy-momentum tensor and metric are completely independent of this circle: only the amplitude of the oscillation influences the metric
Coulomb branch and the moduli space of instantons

The moduli space of instantons on ℂ 2 for any simple gauge group is studied using the Coulomb branch of N = 4 $$ \mathcal{N}=4 $$ gauge theories in three dimensions. For a given simple group G , the Hilbert series of such an instanton moduli space is computed from the Coulomb branch of the quiver given by the over-extended Dynkin diagram of G . The computation includes the cases of non-simply-laced gauge groups G , complementing the ADHM constructions which are not available for exceptional gauge groups. Even though the Lagrangian description for non-simply laced Dynkin diagrams is not currently known, the prescription for computing the Coulomb branch Hilbert series of such diagrams is very simple. For instanton numbers one and two, the results are in agreement with previous works. New results and general features for the moduli spaces of three and higher instanton numbers are reported and discussed in detail
In vitro and in vivo efficacy of edelfosine-loaded lipid nanoparticles against glioma

Edelfosine is the prototype molecule of a family of anticancer drugs collectively known as synthetic alkyl-lysophospholipids. This drug holds promise as a selective antitumor agent, and a number of preclinical assays are in progress. In this study, we observe the accumulation of edelfosine in brain tissue after its oral administration in Compritol (R) and Precirol (R) lipid nanoparticles (LN). The high accumulation of edelfosine in brain was due to the inhibition of P-glycoprotein by Tween (R) 80, as verified using a P-glycoprotein drug interaction assay. Moreover, these LN were tested in vitro against the C6 glioma cell line, which was later employed to establish an in vivo xenograft mouse model of glioma. In vitro studies revealed that edelfosine-loaded LN induced an antiproliferative effect in C6 glioma cell line. In addition, in vivo oral administration of drug-loaded LN in NMRI nude mice bearing a C6 glioma xenograft tumor induced a highly significant reduction in tumor growth (p<0.01) 14 days after the beginning of the treatment. Our results showed that Tween (R) 80 coated Compritol (R) and Precirol (R) LN can effectively inhibit the growth of C6 glioma cells in vitro and suggest that edelfosine-loaded LN represent an attractive option for the enhancement of antitumor activity on brain tumors in vivo.Caja Navarra Foundation, Ibercaja, the Government of Navarra, Department of Health (“Ortiz de Landázuri” fellowship, ref: 63/09), the Spanish Ministry of Science and Innovation (SAF2007-61261, SAF2008-02251, SAF2010-15547, PCT-090100-2007-27, RD06/0020/1037 from Red Temática de Investigación Cooperativa en Cáncer, Instituto de Salud Carlos III, cofunded by the Fondo Europeo de Desarrollo Regional of the European Union) and University of Navarra (FUN). Ander Estella-Hermoso de Mendoza is supported by a research grant from the Department of Education of the Basque Government (BFI06.37).Peer Reviewe
The renin-angiotensin system is modulated by swimming training depending on the age of spontaneously hypertensive rats

Aim: To investigate the effects of swimming training on the renin-angiotensin system (RAS) during the development of hypertensive disease.Main methods: Male spontaneously hypertensive rats (SHR) were randomized into: sedentary young (SY), trained young (TV), sedentary adult (SA), and trained adult (TA) groups. Swimming was performed 5 times/wk/8wks.Key findings: Trained young and adult rats showed both decreased systolic and mean blood pressure, and bradycardia after the training protocol. the left ventricular hypertrophy (LVH) was observed only in the TA group (12.7%), but there was no increase on the collagen volume fraction. Regarding the components of the RAS, TV showed lower activity and gene expression of angiotensinogen (AGT) compared to SY. the TA group showed lower activity of circulatory RAS components, such as decreased serum ACE activity and plasma renin activity compared to SA. However, depending on the age, although there were marked differences in the modulation of the RAS by training, both trained groups showed a reduction in circulating angiotensin II levels which may explain the lower blood pressure in both groups after swimming training.Significance: Swimming training regulates the RAS differently in adult and young SHR rats. Decreased local cardiac RAS may have prevented the LVH exercise-induced in the TV group. Both groups decreased serum angiotensin II content, which may, at least in part, contribute to the lowering blood pressure effect of exercise training. (C) 2011 Elsevier Inc. All rights reserved.Univ São Paulo, Sch Phys Educ & Sport, Biochem Lab, BR-05508900 São Paulo, BrazilUniv São Paulo Med Sch, Heart Inst InCor, Hypertens Unit, São Paulo, SP, BrazilUniversidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, SP, BrazilUniv São Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, SP, BrazilWeb of Scienc
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis
Measurements of fiducial and differential cross sections for Higgs boson production in the diphoton decay channel at s√=8TeV with ATLAS

Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of TeV. The analysis is performed in the H -&gt; gamma gamma decay channel using 20.3 fb(-1) of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assuming that the width of the resonance is much smaller than the experimental resolution. The signal yields are corrected for the effects of detector inefficiency and resolution. The pp -&gt; H -&gt; gamma gamma fiducial cross section is measured to be 43.2 +/- 9.4(stat.) (-aEuro parts per thousand 2.9) (+ 3.2) (syst.) +/- 1.2(lumi)fb for a Higgs boson of mass 125.4GeV decaying to two isolated photons that have transverse momentum greater than 35% and 25% of the diphoton invariant mass and each with absolute pseudorapidity less than 2.37. Four additional fiducial cross sections and two cross-section limits are presented in phase space regions that test the theoretical modelling of different Higgs boson production mechanisms, or are sensitive to physics beyond the Standard Model. Differential cross sections are also presented, as a function of variables related to the diphoton kinematics and the jet activity produced in the Higgs boson events. The observed spectra are statistically limited but broadly in line with the theoretical expectations.<p>ATLAS Collaboration, for complete list of authors see http://dx.doi.org/10.1007/JHEP09(2014)112</p
Metabolic effects of TiO₂ nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes

The long-term health risks of nanoparticles remain poorly understood, which is a serious concern given their prevalence in the environment from increased industrial and domestic use. The extent to which such compounds contribute to cellular toxicity is unclear, and although it is known that induction of oxidative stress pathways is associated with this process, the proteins and the metabolic pathways involved with nanoparticle-mediated oxidative stress and toxicity are largely unknown. To investigate this problem further, the effect of TiO[subscript 2] on the HaCaT human keratinocyte cell line was examined. The data show that although TiO[subscript 2] does not affect cell cycle phase distribution, nor cell death, these nanoparticles have a considerable and rapid effect on mitochondrial function. Metabolic analysis was performed to identify 268 metabolites of the specific pathways involved and 85 biochemical metabolites were found to be significantly altered, many of which are known to be associated with the cellular stress response. Importantly, the uptake of nanoparticles into the cultured cells was restricted to phagosomes, TiO[subscript 2] nanoparticles did not enter into the nucleus or any other cytoplasmic organelle. No other morphological changes were detected after 24-h exposure consistent with a specific role of mitochondria in this response.Peer-reviewedPublisher Versio
Reductive group schemes, the Greenberg functor, and associated algebraic groups.

Let AA be an Artinian local ring with algebraically closed residue field kk, and let View the MathML sourceG be an affine smooth group scheme over AA. The Greenberg functor FF associates to View the MathML sourceG a linear algebraic group View the MathML sourceG≔(FG)(k) over kk, such that View the MathML sourceG≅G(A). We prove that if View the MathML sourceG is a reductive group scheme over AA, and View the MathML sourceT is a maximal torus of View the MathML sourceG, then TT is a Cartan subgroup of GG, and every Cartan subgroup of GG is obtained uniquely in this way. Moreover, we prove that if View the MathML sourceG is reductive and View the MathML sourceP is a parabolic subgroup of View the MathML sourceG, then PP is a self-normalising subgroup of GG, and if View the MathML sourceB and View the MathML sourceB′ are two Borel subgroups of View the MathML sourceG, then the corresponding subgroups BB and B′B′ are conjugate in GG
A robust, fine pitch probe card.

A new type of probe card is described which consists of inclined nickel cantilevers formed on top of a three dimensional PDMS layer. A prototype card has been built with an in-line pitch of 23 μm. The presence of a PDMS layer beneath the cantilevers creates mechanically robust probes. The probes can apply up to 100 mN contact force and be deflected up to 40 μm without\ud
damage. Typical contact resistances of less than 5 Ω against gold and 15 Ω against copper are reported. The leakage current between adjacent probes is less than 1 nA measured at 100 V