pinecone/core-2020-05-10-deduplication huggingface dataset:
Centrality dependence of charged particle production at large transverse momentum in Pb–Pb collisions at sNN=2.76 TeV

AbstractThe inclusive transverse momentum (pT) distributions of primary charged particles are measured in the pseudo-rapidity range |η|<0.8 as a function of event centrality in Pb–Pb collisions at sNN=2.76 TeV with ALICE at the LHC. The data are presented in the pT range 0.15<pT<50 GeV/c for nine centrality intervals from 70–80% to 0–5%. The results in Pb–Pb are presented in terms of the nuclear modification factor RAA using a pp reference spectrum measured at the same collision energy. We observe that the suppression of high-pT particles strongly depends on event centrality. The yield is most suppressed in central collisions (0–5%) with RAA≈0.13 at pT=6–7 GeV/c. Above pT=7 GeV/c, there is a significant rise in the nuclear modification factor, which reaches RAA≈0.4 for pT>30 GeV/c. In peripheral collisions (70–80%), only moderate suppression (RAA=0.6–0.7) and a weak pT dependence is observed. The measured nuclear modification factors are compared to other measurements and model calculations
RbAp46/48LIN-53 Is Required for Holocentromere Assembly in Caenorhabditis elegans

SummaryCentromeres, the specialized chromosomal regions for recruiting kinetochores and directing chromosome segregation, are epigenetically marked by a centromeric histone H3 variant, CENP-A. To maintain centromere identity through cell cycles, CENP-A diluted during DNA replication is replenished. The licensing factor M18BP1KNL-2 is known to recruit CENP-A to holocentromeres. Here, we show that RbAp46/48LIN-53, a conserved histone chaperone, is required for CENP-AHCP-3 localization in holocentric Caenorhabditis elegans. Indeed, RbAp46/48LIN-53 and CENP-AHCP-3 localizations are interdependent. RbAp46/48LIN-53 localizes to the centromere during metaphase in a CENP-AHCP-3- and M18BP1KNL-2-dependent manner, suggesting CENP-AHCP-3 loading may occur before anaphase. RbAp46/48LIN-53 does not function at the centromere through histone acetylation, H3K27 trimethylation, or its known chromatin-modifying complexes. RbAp46/48LIN-53 may function independently to escort CENP-AHCP-3 for holocentromere assembly but is dispensable for other kinetochore protein recruitment. Nonetheless, depletion of RbAp46/48LIN-53 leads to anaphase bridges and chromosome missegregation. This study unravels the holocentromere assembly hierarchy and its conservation with monocentromeres
Search for narrow high-mass resonances in proton–proton collisions at s=8 TeV decaying to a Z and a Higgs boson

AbstractA search for a narrow, high-mass resonance decaying into Z and Higgs (H) bosons is presented. The final state studied consists of a merged jet pair and a τ pair resulting from the decays of Z and H bosons, respectively. The analysis is based on a data sample of proton–proton collisions at a center-of-mass energy of 8 TeV, collected with the CMS experiment in 2012, and corresponding to an integrated luminosity of 19.7 fb−1. In the resonance mass range of interest, which extends from 0.8 to 2.5 TeV, the Z and H bosons are produced with large momenta, which implies that the final products of the two quarks or the two τ leptons must be detected within a small angular interval. From a combination of all possible decay modes of the τ leptons, production cross sections in a range between 0.9 and 27.8 fb are excluded at 95% confidence level, depending on the resonance mass
Angular distributions in J/ψ→pp¯π0(η) decays

AbstractThe differential decay rates of the processes J/ψ→pp¯π0 and J/ψ→pp¯η close to the pp¯ threshold are calculated with the help of the NN¯ optical potential. The same calculations are made for the decays of ψ(2S). We use the potential which has been suggested to fit the cross sections of NN¯ scattering together with NN¯ and six pion production in e+e− annihilation close to the pp¯ threshold. The pp¯ invariant mass spectrum is in agreement with the available experimental data. The anisotropy of the angular distributions, which appears due to the tensor forces in the NN¯ interaction, is predicted close to the pp¯ threshold. This anisotropy is large enough to be investigated experimentally. Such measurements would allow one to check the accuracy of the model of NN¯ interaction
Acute COPD exacerbation: 3 T MRI evaluation of pulmonary regional perfusion – Preliminary experience

SummaryObjectivesTo compare pulmonary perfusion parameters by means of dynamic perfusion magnetic resonance in patients affected by chronic obstructive pulmonary disease (COPD), during and after acute exacerbation.MethodsFifteen patients were successfully evaluated with perfusional MRI during an acute exacerbation of COPD and upon clinical stabilization. Inclusion criteria were a PaCO2 > 45 mmHg and respiratory acidosis (arterial blood pH < 7.35) at admittance.ResultsIn the acute phase a reduction of pulmonary blood flow (PBF) and pulmonary blood volume (PBV), and a significant prolonging of the mean transit time (MTT) and time to peak (TTP) were observed in all patients. In the stabilization phase a significant increase of PBF and PBV and a significant reduction of MTT and TTP were observed in 6 patients; no significant variations were observed in the other 9 patients.Conclusion3D time-resolved contrast-enhanced MRI allows quantitative evaluation of pulmonary regional perfusion in patients affected by COPD, identifying patients in which perfusion defects are resolved in the clinical-stabilization phase.This technique might allow the identification of patients in whom vasospasm may be the main responsible of pulmonary hypoperfusion during acute COPD exacerbation, with potential advantages on the clinical management of these patients
New methods for investigating slag heaps: Integrating geoprospection, excavation and quantitative methods at Meroe, Sudan

AbstractThis paper describes a multifaceted approach to the investigation of iron slag heaps, focusing on one of the slag heaps at the Royal City of Meroe in Sudan. This study marries together geoprospection data (gradiometry and electrical resistivity transects), topographic data and quantitative excavation data, to provide an analysis and comparison of the total volume, slag component and slag composition of a slag-heap. Significantly, the results demonstrate the limitations of using a topographic only model, but also demonstrate how volumetric modelling must be integrated within quantitative characterisation of slag-heap composition. In this case, quantitative sampling of the slag deposits revealed the composition of the slag assemblage was dominated by a newly defined category of slag which has major implications for reconstructing iron technologies in the Meroitic civilisation. This research highlights the dangers of applying simplistic models and basic investigative strategies to iron slag heaps and furthers the debate on applying volumetric modelling and excavation sampling to unexcavated areas of the finite and important resource of archaeometallurgical deposit sequences
Remarks on the pion–nucleon σ-term

AbstractThe pion–nucleon σ-term can be stringently constrained by the combination of analyticity, unitarity, and crossing symmetry with phenomenological information on the pion–nucleon scattering lengths. Recently, lattice calculations at the physical point have been reported that find lower values by about 3σ with respect to the phenomenological determination. We point out that a lattice measurement of the pion–nucleon scattering lengths could help resolve the situation by testing the values extracted from spectroscopy measurements in pionic atoms
Exceptional collections, and the Néron–Severi lattice for surfaces

AbstractWe work out properties of smooth projective varieties X over a (not necessarily algebraically closed) field k that admit collections of objects in the bounded derived category of coherent sheaves Db(X) that are either full exceptional, or numerically exceptional of maximal length. Our main result gives a necessary and sufficient condition on the Néron–Severi lattice for a smooth projective surface S with χ(OS)=1 to admit a numerically exceptional collection of maximal length, consisting of line-bundles. As a consequence we determine exactly which complex surfaces with pg=q=0 admit a numerically exceptional collection of maximal length. Another consequence is that a minimal geometrically rational surface with a numerically exceptional collection of maximal length is rational
In situ rolling circle amplification detection of Crimean Congo hemorrhagic fever virus (CCHFV) complementary and viral RNA

AbstractCrimean Congo hemorrhagic fever virus (CCHFV) is a human pathogen that causes a severe disease with high fatality rate for which there is currently no specific treatment. Knowledge regarding its replication cycle is also highly limited. In this study we developed an in situ technique for studying the different stages during the replication of CCHFV. By integrating reverse transcription, padlock probes, and rolling circle amplification, we were able to detect and differentiate between viral RNA (vRNA) and complementary RNA (cRNA) molecules, and to detect viral protein within the same cell. These data demonstrate that CCHFV nucleocapsid protein (NP) is detectable already at 6hours post infection in vRNA- and cRNA-positive cells. Confocal microscopy showed that cRNA is enriched and co-localized to a large extent with NP in the perinuclear area, while vRNA has a more random distribution in the cytoplasm with only some co-localize with NP. However, vRNA and cRNA did not appear to co-localize directly
Covert visual search within and beyond the effective oculomotor range

AbstractCovert spatial attention is tightly coupled to the eye-movement system, but the precise nature of this coupling remains contentious. Recent research has argued that covert attention and overt eye-movements many share a common biological limit, such that covert exogenous orienting of attention is limited to stimuli that fall within the range of possible eye movements (the effective oculomotor range: EOMR). However, this conclusion is based on a single experimental paradigm: The Posner cueing task. Here, we examine the extent to which covert spatial attention is limited to the EOMR in visual search. Exogenous attention was assessed using a feature search task and endogenous attention assessed using a conjunction search task. The tasks were performed monocularly with the dominant eye in the frontal position or abducted by 40°. In the abducted position stimuli in the temporal hemispace could be seen, but could not become the goal of a saccadic eye-movement (i.e. they were beyond the EOMR). In contrast, stimuli in the nasal hemifield remained within the EOMR. We observed a significant effect of eye-abduction on feature search, such that search was slower when targets appeared beyond the EOMR. In contrast, eye-abduction had no effect on search times during conjunction search. Set size did not interact with target location or eye-position. It is concluded that optimal covert orienting of exogenous attention in visual search is restricted to locations within the effective oculomotor range
The emerging case for axion dark matter

AbstractDark matter axions form a rethermalizing Bose–Einstein condensate. This provides an opportunity to distinguish axions from other forms of dark matter on observational grounds. I show that if the dark matter is axions, tidal torque theory predicts a specific structure for the phase space distribution of the halos of isolated disk galaxies, such as the Milky Way. This phase space structure is precisely that of the caustic ring model, for which observational support had been found earlier. The other dark matter candidates predict a different phase space structure for galactic halos
Inactivation of the HR6B Ubiquitin-Conjugating DNA Repair Enzyme in Mice Causes Male Sterility Associated with Chromatin Modification

AbstractThe ubiquitin-conjugating yeast enzyme RAD6 and its human homologs hHR6A and hHR6B are implicated in postreplication repair and damage-induced mutagenesis. The yeast protein is also required for sporulation and may modulate chromatin structure via histone ubiquitination. We report the phenotype of the first animal mutant in the ubiquitin pathway: inactivation of the hHR6B-homologous gene in mice causes male infertility. Derailment of spermatogenesis becomes overt during the postmeiotic condensation of chromatin in spermatids. These findings provide a parallel between yeast sporulation and mammalian spermatogenesis and strongly implicate hHR6-dependent ubiquitination in chromatin remodeling. Since heterozygous male mice and even knockout female mice are completely normal and fertile and thus able to transmit the defect, similar hHR6B mutations may cause male infertility in man
Reconstruction of changes in the Weddell Sea sector of the Antarctic Ice Sheet since the Last Glacial Maximum

AbstractThe Weddell Sea sector is one of the main formation sites for Antarctic Bottom Water and an outlet for about one fifth of Antarctica's continental ice volume. Over the last few decades, studies on glacial–geological records in this sector have provided conflicting reconstructions of changes in ice-sheet extent and ice-sheet thickness since the Last Glacial Maximum (LGM at ca 23–19 calibrated kiloyears before present, cal ka BP). Terrestrial geomorphological records and exposure ages obtained from rocks in the hinterland of the Weddell Sea, ice-sheet thickness constraints from ice cores and some radiocarbon dates on offshore sediments were interpreted to indicate no significant ice thickening and locally restricted grounding-line advance at the LGM. Other marine geological and geophysical studies concluded that subglacial bedforms mapped on the Weddell Sea continental shelf, subglacial deposits and sediments over-compacted by overriding ice recovered in cores, and the few available radiocarbon ages from marine sediments are consistent with major ice-sheet advance at the LGM. Reflecting the geological interpretations, different ice-sheet models have reconstructed conflicting LGM ice-sheet configurations for the Weddell Sea sector. Consequently, the estimated contributions of ice-sheet build-up in the Weddell Sea sector to the LGM sea-level low-stand of ∼130 m vary considerably.In this paper, we summarise and review the geological records of past ice-sheet margins and past ice-sheet elevations in the Weddell Sea sector. We compile marine and terrestrial chronological data constraining former ice-sheet size, thereby highlighting different levels of certainty, and present two alternative scenarios of the LGM ice-sheet configuration, including time-slice reconstructions for post-LGM grounding-line retreat. Moreover, we discuss consistencies and possible reasons for inconsistencies between the various reconstructions and propose objectives for future research. The aim of our study is to provide two alternative interpretations of glacial–geological datasets on Antarctic Ice-Sheet History for the Weddell Sea sector, which can be utilised to test and improve numerical ice-sheet models
Greenhouse gas emissions per unit of value added (“GEVA”) — A corporate guide to voluntary climate action

AbstractHow much must I reduce my greenhouse gas (GHG) emissions if I want to do my fair share to contribute towards the global effort to keep global warming below a 2°C rise in average temperature over preindustrial times? This paper suggests an answer for nations and corporations that want to move ahead of legislation on a voluntary basis.If all nations reduce their “GHG emissions per unit of GDP” by 5% per year, global GHG emissions will be 50% lower in 2050 than in 2010 as long as the global economy continues to grow at its historical rate of 3.5% per year. The suggested 5% per year decline can be translated into a corporate resolution to reduce corporate “GHG emissions per unit of value added” (GEVA) by 5% per year.If all corporations cut their GEVA by 5% per year, the same global result will be achieved. The suggested 5% per year decline can be used as a guideline for responsible action on a voluntary basis. The guideline is unlikely to be made mandatory soon, but compulsory publication of the necessary emissions and productivity data by nations and corporations could help civil society highlight top performers
The ρ-meson longitudinal leading-twist distribution amplitude

AbstractIn the present paper, we suggest a convenient model for the vector ρ-meson longitudinal leading-twist distribution amplitude ϕ2;ρ‖, whose distribution is controlled by a single parameter B2;ρ‖. By choosing proper chiral current in the correlator, we obtain new light-cone sum rules (LCSR) for the B→ρ TFFs A1, A2 and V, in which the δ1-order ϕ2;ρ‖ provides dominant contributions. Then we make a detailed discussion on the ϕ2;ρ‖ properties via those B→ρ TFFs. A proper choice of B2;ρ‖ can make all the TFFs agree with the lattice QCD predictions. A prediction of |Vub| has also been presented by using the extrapolated TFFs, which indicates that a larger B2;ρ‖ leads to a larger |Vub|. To compare with the BABAR data on |Vub|, the longitudinal leading-twist DA ϕ2;ρ‖ prefers a doubly-humped behavior
Looking below the surface: The cultural ecosystem service values of UK marine protected areas (MPAs)

AbstractRecreational users appreciate the UK marine environment for its cultural ecosystem services (CES) and their use and non-use values. UK Governments are currently establishing a network of marine protected areas (MPAs) informed by ecological data and socio-economic evidence. Evidence on CES values is needed, but only limited data have been available. We present a case study from the UK National Ecosystem Assessment (NEA) follow-on phase that elicited divers’ and anglers’ willingness to pay (WTP) for potential MPAs. The case study is an innovative combination of a travel-cost based choice experiment and an attribute-based contingent valuation method. Our study design allowed us to understand the marine users’ preferences from both a user and a stewardship perspective. Following the UK NEA’s place-based CES framework, we characterised marine CES as environmental spaces that might be protected, with features including the underwater seascape, and iconic and non-iconic species. Our survey highlighted the importance of CES to divers and anglers. A wide variety of marine spaces influenced user-WTP, while stewardship-WTP was most influenced by management restrictions, species protection, and attitudes towards marine conservation. An understanding of key stakeholders’ CES values can inform a more holistic and sustainable approach to marine management, especially for decisions involving trade-offs between marine protection and opportunity costs of the blue economy
A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire

SummaryMany infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memory T cells impact the repertoire of T cells responding to new antigens is still largely unknown. We demonstrate that even a minimum epitope overlap between infections strongly increases the activation threshold and narrows the diversity of T cells recruited in response to new antigens. Thus, minimal cross-reactivity between infections can significantly impact the outcome of a subsequent immune response. Interestingly, we found that non-transferrable memory T cells are most effective in raising the activation threshold. Our findings have implications for designing vaccines and suggest that vaccines meant to target low-affinity T cells are less effective when they contain a strong CD8 T cell epitope that has previously been encountered
Limit on the production of a low-mass vector boson in e+e−→Uγ, U→e+e− with the KLOE experiment

AbstractThe existence of a new force beyond the Standard Model is compelling because it could explain several striking astrophysical observations which fail standard interpretations. We searched for the light vector mediator of this dark force, the U boson, with the KLOE detector at the DAΦNE e+e− collider. Using an integrated luminosity of 1.54 fb−1, we studied the process e+e−→Uγ, with U→e+e−, using radiative return to search for a resonant peak in the dielectron invariant-mass distribution. We did not find evidence for a signal, and set a 90% CL upper limit on the mixing strength between the Standard Model photon and the dark photon, ε2, at 10−6–10−4 in the 5–520 MeV/c2 mass range
Competitive advantage in public sector organizations : explaining the public good/sustainable competitive advantage paradox

Resource based views of the firm and in particular Kay’s (1995) model of sustainable competitive advantage have been used to advance an understanding of differences in the competitive advantage of private sector firms. We extend the analysis to a public sector firm where its major purpose includes engaging in public good by giving away its knowledge base and services. The case highlights the paradox that many public sector organisations face in simultaneously pursuing public good and sustainable competitive advantage. While Kay’s model is applicable for understanding intergovernmental agency competition, we find it necessary to incorporate Resource Dependency Theory to address the paradox. Implications for theory and practice are provided
The 2008 floods in Queensland: a case study of vulnerability, resilience and adaptive capacity

This report on the 2008 Floods in Queensland: Charleville and Mackay forms part of a series of studies/reports commissioned by NCCARF that look at historical extreme weather events, their impacts and subsequent adaptations. These studies examine particular events – primarily extremes – and seek to explore prior vulnerabilities and resilience, the character and management of the event, subsequent adaptation, and the effects on present-day vulnerability.\ud
The reports should inform thinking about adapting to climate change, i.e. capacity to adapt, barriers to adaptation, and translating capacity into action. While it is recognised that the comparison is not and never can be exact, the overarching goal is to better understand the\ud
requirements of successful adaptation to future climate change
A Multi-Agent based Configuration Process for Mass Customization

Large product variety in mass customization involves a high internal complexity level inside a companyís operations, as well as a high external complexity level from a customerís perspective. In order to reach a competitive advantage through mass customization, it is necessary to cope with both problems. This is done within the scope of variety formation and variety steering tasks: Variety formation supports customers during the configuration task according to their preferences and knowledge, variety steering tasks internally deal with finding the customizerís optimal offer. Driven by this economic background, we present a comprehensive multi-agent based design for a configuration process in this paper. It is identified as a suitable solution approach integrating both perspectives. The mass customized products are assumed to be based on a
modular architecture and each module variant is associated with an autonomous rational agent. Agents must compete with each other in order to join product variants which suit real customersí requirements. The negotiation process is based on a market mechanism supported by the target costing concept and a Dutch auction.