pinecone/core-2020-05-10-deduplication huggingface dataset:
Cognitive Behavioral Therapy with Daily Mindfulness Training: a Case Report of Comorbid Binge Eating and Bipolar Disorders

International audienceBinge eating and mood disorders are highly comorbid, but psychological therapies solely target on one or the other. The current clinical case report aims to describe one application of cognitive behavioral therapy (CBT) with mindfulness training for binge eating and bipolar disorders. Treatment in a 49-year-old female consisted of 12 weekly individual CBT sessions with daily mindfulness training. Progress in treatment was assessed and monitored every four weeks via validated eating behavior, depression, anxiety, impulsivity, and motivation towards therapy measures. The patient reported increased eating and cognitive impulsivity, decreased number of binge episodes, and increased psychological flexibility. Due to mood alteration, the results showed a negative association between depressive symptoms and motivational regulation. Daily mindfulness training, including psychoeducation and a positive therapeutic alliance, can be applied to obese patients with psychiatric disorders underlying their eating disorders
Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective french research axed on tolerance of biotherapies registry.

International audienceOBJECTIVE: Tuberculosis (TB) is associated with anti-tumor necrosis factor (anti-TNF) monoclonal antibody (mAb) therapy, but whether this association is drug-specific remains a concern. Our objective was to describe cases of TB associated with anti-TNF mAb therapy, identify risk factors, and estimate the incidence. METHODS: We conducted an incidence study and a case-control analysis to investigate the risk of newly diagnosed TB associated with the use of anti-TNF agents. As part of the French Research Axed on Tolerance of Biotherapies (RATIO) registry, for 3 years we collected cases of TB among French patients receiving anti-TNF mAb therapy for any indication; for each case, 2 patients treated with anti-TNF agents served as control subjects. RESULTS: We collected 69 cases of TB in patients treated for rheumatoid arthritis (n = 40), spondylarthritides (n = 18), inflammatory colitis (n = 9), psoriasis (n = 1) and Behçet's disease (n = 1) with infliximab (n = 36), adalimumab (n = 28), and etanercept (n = 5). None of the patients had received correct chemoprophylactic treatment. The sex- and age-adjusted incidence rate of TB was 116.7 per 100,000 patient-years. The standardized incidence ratio (SIR) was 12.2 (95% confidence interval [95% CI] 9.7-15.5) and was higher for therapy with infliximab and adalimumab than for therapy with etanercept (SIR 18.6 [95% CI 13.4-25.8] and SIR 29.3 [95% CI 20.3-42.4] versus SIR 1.8 [95% CI 0.7-4.3], respectively). In the case-control analysis, exposure to infliximab or adalimumab versus etanercept was an independent risk factor for TB (odds ratio [OR] 13.3 [95% CI 2.6-69.0] and OR 17.1 [95% CI 3.6-80.6], respectively). Other risk factors were age, the first year of anti-TNF mAb treatment, and being born in an endemic area. CONCLUSION: The risk of TB is higher for patients receiving anti-TNF mAb therapy than for those receiving soluble TNF receptor therapy. The increased risk with early anti-TNF treatment and the absence of correct chemoprophylactic treatment favor the reactivation of latent TB
Cognitive ability and the effect of strategic uncertainty

International audienceHow is one's cognitive ability related to the way one responds to strategic uncertainty? We address this question by conducting a set of experiments in simple 2 × 2 dominance solvable coordination games. Our experiments involve two main treatments: one in which two human subjects interact, and another in which one human subject interacts with a computer program whose behavior is known. By making the behavior of the computer perfectly predictable, the latter treatment eliminates strategic uncertainty. We find that subjects with higher cognitive ability are more sensitive to strategic uncertainty than those with lower cognitive ability
Maxisets for model selection

35 pagesInternational audienceWe address the statistical issue of determining the maximal spaces (maxisets) where model selection procedures attain a given rate of convergence. By considering first general dictionaries, then orthonormal bases, we characterize these maxisets in terms of approximation spaces. These results are illustrated by classical choices of wavele model collections. For each of them, the maxisets are described in terms of functional spaces. We take a special case of the issue of calculability and measure the induced loss of performance in terms of maxisets
Multicentre study using strain delay index for predicting response to cardiac resynchronization therapy (MUSIC study).
 : 
Strain Delay Index and Response to CRT

International audienceAIMS: Strain delay index (SDI) allows quantification of the wasted contraction or gain of myocardial contractility expected after cardiac resynchronization therapy (CRT). The present multicentre prospective study aimed to assess the accuracy of the SDI in predicting responses to CRT in real-life patients with wide and narrow (<130 ms) QRS complexes. METHODS AND RESULTS: Implantation of a CRT device was performed in 235 heart failure patients and echocardiography data were analysable in 80% (n= 189) of patients (age 65 ± 12 years, left ventricular ejection fraction = 26 ± 8%, 63 ischaemic, 51 with narrow QRS complexes). Mechanical dyssynchrony before CRT was quantified by the 12-segment standard deviation of peak longitudinal strain by speckle tracking (12SD-ε, 12 standard deviation of time to peak strain by speckle tracking), and SDI, defined as the sum of difference between end-systolic and peak-ε across the 16 segments. Response to CRT was defined as an end-systolic volume reduction (ESVR) at 6 months >15%. After CRT, ESVR>15% was observed in 60% (n= 114/189) of patients, and was greater in non-ischaemic (68 vs. 44%, P= 0.003) and wide QRS patients (65 vs. 49%, P= 0.04). Correlation between 12SD-ε and ESVR was poor (r = 0.18, P= 0.01). In contrast, SDI correlated with reverse remodelling (r = 0.61, P< 0.0001 for all) in both wide and narrow QRS patients and ischaemic and non-ischaemic patients. Decrease in SDI after CRT was greater in responders and correlated with ESVR. Finally, SDI > 25% identified responders to CRT (positive and negative predictive value of 80 and 84%, respectively) with 6% inter-observer variability. CONCLUSION: The present multicentre study suggests that SDI may identify responders to CRT in ischaemic and non-ischaemic patients
Track of fluid paleocirculation in dolomite host rock at regional scale by the Anisotropy of Magnetic Susceptibility (AMS): An example from Aptian carbonates of La Florida (Northern Spain)

International audienceThe present study aims to apply the AMS method (Anisotropy of Magnetic Susceptibility) at a regional scale to track the fluid circulation direction that has produced an iron metasomatism within pre-existing dolomite host rock. The Urgonian formations hosting the Zn-Pb mineralizations in La Florida (Cantabria, northern Spain) have been taken as target for this purpose. Sampling was carried out, in addition to ferroan dolomite host rock enclosing the Zn-Pb mineralizations, in dolomite host rock and limestone to make the comparison possible between magnetic signals from mineralized rocks, where fluid circulation occurred, and their surrounding formations. AMS study was coupled with petrofabric analysis carried out by texture goniometry, Scanning Electron Microscopy (SEM) observations and also Shape Preferred Orientation (SPO) statistics. SEM observations of ferroan dolomite host rock illustrate both bright and dark grey ribbons corresponding respectively to Fe enriched and pure dolomites. SPO statistics applied on four images from ferroan dolomite host rock give a well defined orientation of ribbons related to the intermediate axis of magnetic susceptibility K2. For AMS data, two magnetic fabrics are observed. The first one is observed in ferroan dolomite host rock and characterised by a prolate ellipsoid of magnetic susceptibility with a vertical magnetic lineation. The magnetic susceptibility carrier is Fe-rich dolomite. These features are probably acquired during metasomatic fluid circulations. In Fe-rich dolomite host rock, ‹c› axes are vertical. As a rule, (0001) planes (i.e. planes perpendicular to ‹c› axes) are isotropic with respect to crystallographic properties. So, the magnetic anisotropy measured in this plane should reflect crystallographic modification due to fluid circulation. This is confirmed by the texture observed using the SEM. Consequently, AMS results show a dominant NE-SW elongation interpreted as the global circulation direction and a NW-SE secondary elongation that we have considered as sinuosities of the fluid trajectory. The second type of magnetic fabric is essentially observed in the limestone and characterised by an oblate form of the ellipsoid of magnetic susceptibility, a horizontal magnetic foliation and mixed magnetic susceptibility carriers. It is interpreted as a sedimentary fabric
Random monitoring in financing relationships

International audienceThis paper examines a financier's optimal monitoring intensity in a multi-period financing relationship.We identify conditions under which the financier should sometimes misidentify the quality of an entrepreneur. Such an imperfect evaluation technology affects action choices by bad entrepreneurs. We first characterize the optimal monitoring intensity and show that it is one in which the investor monitors entrepreneurs randomly. Random monitoring in the first stage of a relationship induces bad entrepreneurs to reveal their intrinsic types. Second, because random monitoring reduces the share of bad entrepreneurs in the subsequent periods, we show that the financier can therefore realize substantial gains
Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: Association with subtype, body-mass index, severity and age of onset.

Anorexia nervosa (AN) affects 0.3% of young girls with a mortality of 6%/decade and is strongly familial with genetic factors. Ghrelin is an upstream regulator of the orexigenic peptides NPY and AgRP and acts as a natural antagonist to leptin's effects on NPY/AgRP-expressing neurons, resulting in an increase in feeding and body weight. Obestatin which counteracts ghrelin action on feeding is derived from the same propeptide than ghrelin. BDNF has been involved in body weight regulation and its Val66Met polymorphism associated with AN. We therefore re-investigated the association between AN and the Leu72Met and Gln90Leu polymorphisms of the prepro-ghrelin/obestatin gene, the Ala67Thr polymorphism of AgRP and the Val66Met polymorphism of BDNF taking into account clinical subtypes (restrictive-ANR-and bingeing/purging-ANB-subtypes). Family trios study of these 4 single nucleotide polymorphisms were performed in 114 probands with AN and both their parents recruited in two specialized French centres. A transmission disequilibrium was observed for the Leu72Met SNP of the preproghrelin gene and for the Ala67Thr SNP of the AgRP gene. When stratified by clinical subtype, these two polymorphisms were preferentially transmitted for the trios with a bingeing/purging proband. An excess of transmission of the Gln90Leu72 preproghrelin/obestatin haplotype in patients with AN was observed. These results do not provide evidence for a preferential transmission of the 66Met allele of BDNF but support the hypothesis that ghrelin and AGRP polymorphisms confers susceptibility to AN. Further simultaneous analysis of genetic variants of the biological determinants of energy metabolism and feeding behaviour in very large populations should contribute to the understanding of the high degree of heritability of eating disorders and to the description of pathophysiological patterns leading to life-threatening conditions in a highly redundant system
Helium behaviour in implanted boron carbide

International audienceWhen boron carbide is used as a neutron absorber in nuclear power plants, large quantities of helium are produced. To simulate the gas behaviour, helium implantations were carried out in boron carbide. The samples were then annealed up to 1500 °C in order to observe the influence of temperature and duration of annealing. The determination of the helium diffusion coefficient was carried out using the 3 He(d,p) 4 He nuclear reaction (NRA method). From the evolution of the width of implanted 3 He helium profiles (fluence 1 Â 10 15 /cm 2 , 3 MeV corresponding to a maximum helium concentration of about 10 20 /cm 3) as a function of annealing temperatures, an Arrhenius diagram was plotted and an apparent diffusion coefficient was deduced (E a = 0.52 ± 0.11 eV/atom). The dynamic of helium clusters was observed by transmission electron microscopy (TEM) of samples implanted with 1.5 Â 10 16 /cm 2 , 2.8 to 3 MeV 4 He ions, leading to an implanted slab about 1 mm wide with a maximum helium concentration of about 10 21 /cm 3. After annealing at 900 °C and 1100 °C, small (5–20 nm) flat oriented bubbles appeared in the grain, then at the grain boundaries. At 1500 °C, due to long-range diffusion, intra-granular bubbles were no longer observed; helium segregates at the grain boundaries, either as bubbles or inducing grain boundaries opening
Kinetics and mechanism of reaction between water vapor, carbon monoxide and a chromia-forming nickel base alloy

International audienceThe kinetic aspects of the competitive reaction of CO and H<sub>2</sub>O in the formation of chromia layer on a nickel base alloy at high temperature were studied by thermogravimetry combined to gas phase chromatography. It was shown that competitive adsorption occurred between both molecules and that whatever PCO/PH<sub>2</sub>O ratio, CO mainly reacted in the first instants of oxidation and H<sub>2</sub>O became the main long-term oxidant species. After an interfacial and diffusion mixed kinetic regime, the long-term oxidation rate was parabolic and did not depend on the water vapor content in the gas phase. The oxidation kinetics was well described by considering that the rate limiting step was the outwards diffusion of interstitial chromium cations in the oxide layer
High-resolution sedimentary record of the last deglaciation from a high-altitude lake in Ethiopia

International audienceSedimentological and geochemical studies conducted on a 15.82-m long core collected from Lake Garba Guracha (Ethiopia) associated with a precise AMS-14C time-scale document a unique record of the sedimentary processes linked to the progressive retreat of a high-altitude glacier in the Bale Mountains since 17,000 yr cal BP. Lake sedimentation is interpreted as the result of discharges of meltwater and glaciogenic sediment which progressively filled the accommodation space generated by glacier retreat within the basin. Monogenic sediment originated from glacial erosion of the trachytic tuff forming the cirque floor. Ice melting ended progressively between 12,600 and 11,800 cal BP, as suggested by the decrease in sedimentation energy followed by a sharp change in sedimentary facies. From 11,800 cal BP, the lake reached its maximum development and clastic input was replaced by organic-rich sedimentation. This relates to a major increase of lake productivity, which lasted up to 4500 cal BP. From this period, a lowering in productivity reflects the widespread dryness which occurred throughout the East African tropics
Phase Transitions in Finite Systems using Information Theory

International audience(abridged) In this paper, we present the issues we consider as essential as far as the statistical mechanics of finite systems is concerned. In particular, we emphasis our present understanding of phase transitions in the framework of information theory. Information theory provides a thermodynamically-consistent treatment of finite, open, transient and expanding systems which are difficult problems in approaches using standard statistical ensembles. As an example, we analyze is the problem of boundary conditions, which in the framework of information theory must also be treated statistically. We recall that out of the thermodynamical limit the different ensembles are not equivalent and in particular they may lead to dramatically different equation of states, in the region of a first order phase transition. We recall the recent progresses achieved in the understanding of first-order phase transition in finite systems: the equivalence between the Yang-Lee theorem and the occurrence of bimodalities in the intensive ensemble and the presence of inverted curvatures of the thermodynamic potential of the associated extensive ensemble
Mistral and Tramontane wind speed and wind direction patterns in regional climate simulations

International audienceThe Mistral and Tramontane are important wind phenomena that occur over southern France and the northwestern Mediterranean Sea. Both winds travel through constricting valleys before flowing out towards the Mediterranean Sea. The Mistral and Tramontane are thus interesting phenomena, and represent an opportunity to study channeling effects, as well as the interactions between the atmosphere and land/ocean surfaces. This study investigates Mistral and Tramontane simulations using five regional climate models with grid spacing of about 50 km and smaller. All simulations are driven by ERA-Interim reanalysis data. Spatial patterns of surface wind, as well as wind development and error propagation along the wind tracks from inland France to offshore during Mistral and Tramontane events, are presented and discussed. To disentangle the results from large-scale error sources in Mistral and Tramontane simulations, only days with well simulated large-scale sea level pressure field patterns are evaluated. Comparisons with the observations show that the large-scale pressure patterns are well simulated by the considered models, but the orographic modifications to the wind systems are not well simulated by the coarse-grid simulations (with a grid spacing of about 50 km), and are reproduced slightly better by the higher resolution simulations. On days with Mistral and/or Tramontane events, most simulations underestimate (by 13 % on average) the wind speed over the Mediterranean Sea. This effect is strongest at the lateral borders of the main flow—the flow width is underestimated. All simulations of this study show a clockwise wind direction bias over the sea during Mistral and Tramontane events. Simulations with smaller grid spacing show smaller biases than their coarse-grid counterparts
Stable isotope characterization of pedogenic and lacustrine carbonates from the Chinese Tian Shan: constraints on the Mesozoic - Lower Cenozoic palaeo-environmental evolution

International audienceIn the Mesozoic–Cenozoic continental deposits of the Tian Shan area, two main levels containing pedogenic carbonates have been identified on both the southern and northern foothills of the range: one in the Upper Jurassic series and one in the Upper Cretaceous–Lower Palaeocene series. In order to reconstruct the palaeoenvironmental and palaeotopographic characteristics of the Tian Shan area during these two periods, we measured the oxygen and carbon isotope composition of these pedogenic carbonates (calcrete and nodules). The stable isotope compositions are homogeneous: most δ18O values are between 21 and 25‰ and most δ13C values are between −4 and −6‰. No distinction can be made between the calcrete and nodule isotopic compositions. The constancy of isotopic values across the Tian Shan is evidence of a development of these calcification features in similar palaeoenvironmental conditions. The main inference is that no significant relief existed in that area at the Cretaceous−Palaeogene boundary, implying that most of the present relief developed later, during the Cenozoic. In addition to the pedogenic carbonates, few beds of limestones interstratified in the Jurassic series of the southern foothills display oxygen and carbon isotope compositions typical of lacustrine carbonates, ruling out brackish water incursion at that period in the regio
WAVELET REGULARIZATION OF A FOURIER-GALERKIN METHOD FOR SOLVING THE 2D INCOMPRESSIBLE EULER EQUATIONS

International audienceWe employ a Fourier-Galerkin method to solve the 2D incompressible Euler equations, and study several ways to regularize the solution by wavelet ﬁltering at each timestep. Real-valued orthogonal wavelets and complex-valued wavelets are considered, combined with either linear or non-linear ﬁltering. The results are compared with those obtained via classical viscous and hyperviscous regularization methods. Wavelet regularization using complex-valued wavelets performs as well in terms of L2 convergence rate to the reference solution. The compression rate for homogeneous 2D turbulence is around 3 for this method, suggesting that memory and CPU time could be reduced in an adaptive wavelet computation. Our results also suggest L2 convergence to the reference solution without any regularization, in contrast to what is obtained for the 1D Burgers equation
Structural development of the Lower Paleozoic belt of South China: Genesis of an intracontinental orogen

International audienceAn extensive structural study of Wuyishan and surrounding areas (South China) brings data on the structures formed prior to the Devonian unconformity, building the Lower Paleozoic belt. An Ordovician tectonic event was responsible for: (i) south-directed structures in the Wuyishan proper and its southern border, related to both thin and thick-skinned tectonics, accompanied by metamorphism and crustal thickening; (ii) north-directed structures to the west of Ganjiang Fault and north of Jiangshan-Shaoxing Fault, where only thin-skinned tectonics is visible. The southward deformation accommodating the shortening includes emplacement of thrust sheets, involving deep crustal material and some mantle peridotite, and likely repetition of continental material, both responsible for crustal thickening. The orogeny was due to the underthrusting of the southern part of the South China Block beneath the northern part of this block, closing the pre-existing Nanhua rift, created at around 850-800 Ma, and involving the rift sedimentary fill in the southward thrusting. The syn-metamorphic tectonic piling was followed by anatexis and granite emplacement at around 440-390 Ma. Our new U-Th-Pb EPMA monazite dating gives ages of 433 ± 9 Ma and 437 ± 5 Ma (Early Silurian) for the main anatectic event, and a younger age of 412 ± 5 Ma (Late Silurian-Early Devonian) for a late re-heating process. The Lower Paleozoic belt is an intracontinental orogen, without oceanic suture record. It shows some similarities with the Cenozoic European Pyrénées Chain, with a strong asymmetry
Anticipation of ETX Metric to manage Mobility in Ad Hoc Wireless Networks

International audienceWhen a node is moving in a wireless network, the routing metrics associated to its wireless links may reflect link quality degrada- tions and help the routing process to adapt its routes. Unfortunately, an important delay between the metric estimation and its inclusion in the routing process makes this approach inefficient. In this paper, we intro- duce an algorithm that predicts metric values a few seconds in advance, in order to compensate the delay involved by the link quality measurement and their dissemination by the routing protocol. We consider classical metrics, in particular ETX (Expected Transmission Count) and ETT (Expected Transmission Time), but we combine their computations to our prediction algorithm. Extensive simulations show the route enhance- ment as the Packet Delivery Ratio (PDR) is close to 1 in presence of mobility