pinecone/core-2020-05-10-deduplication huggingface dataset:
Identification of a new locus at 16q12 associated with time-to-asthma onset

International audienceBackground: Asthma is a heterogeneous disease in which age-of-onset plays an important role.Objective: We sought to identify the genetic variants associated with time-to-asthma onset.Methods: We conducted a large-scale meta-analysis of nine genome-wide association studies of time-to-asthma onset (total of 5,462 asthmatics with a broad range of age-of-asthma onset and 8,424 controls of European ancestry) performed using survival analysis techniques.Results: We detected five regions associated with time-to-asthma onset at genome-wide significant level (P<5x10-8). We evidenced a new locus in 16q12 region (near cylindromatosis turban tumor syndrome gene (CYLD)) and confirmed four asthma risk regions: 2q12 (IL1RL1), 6p21 (HLA-DQA1), 9p24 (IL33) and 17q12-q21 (ZPBP2-GSDMA). Conditional analyses identified two distinct signals at 9p24 (both upstream of IL33) and at 17q12-q21 (near ZPBP2 and within GSDMA). These seven distinct loci explained together 6.0% of the variance in time-to-asthma onset. In addition, we showed that genetic variants at 9p24 and 17q12-q21 were strongly associated with an earlier onset of childhood asthma (P≤0.002) whereas 16q12 SNP was associated with a later asthma onset (P=0.04). A high burden of disease risk alleles at these loci was associated with earlier age-of-asthma onset (4 years versus 9-12 years, P=10-4).Conclusion: The new susceptibility region for time-to-asthma onset at 16q12 harbors variants that correlate with the expression of CYLD and NOD2 (nucleotide-binding oligomerization domain 2), two strong candidates for asthma. This study demonstrates that incorporating the variability of age-of-asthma onset in asthma modeling is a helpful approach in the search for disease susceptibility genes
Measurement of dijet production with a veto on additional central jet activity in pp collisions at root s=7 TeV using the ATLAS detector

A measurement of jet activity in the rapidity interval bounded by a dijet system is presented. Events are vetoed if a jet with transverse momentum greater than 20 GeV is found between the two boundary jets. The fraction of dijet events that survive the jet veto is presented for boundary jets that are separated by up to six units of rapidity and with mean transverse momentum 50 < <(p)over bar>T < 500 GeV. The mean multiplicity of jets above the veto scale in the rapidity interval bounded by the dijet system is also presented as an alternative method for quantifying perturbative QCD emission. The data are compared to a next-to-leading order plus parton shower prediction from the POWHEG-BOX, an all-order resummation using the HEJ calculation and the PYTHIA, HERWIG++ and ALPGEN event generators. The measurement was performed using pp collisions at root s = 7 TeV using data recorded by the ATLAS detector in 2010
Measurement of the branching fractions of Ds+→η'X and Ds+→η'ρ+ in e+e-→Ds+Ds-

Çetin, Serkant Ali (Dogus Author)We study Ds+ decays to final states involving the η' with a 482 pb-1 data sample collected at s=4.009 GeV with the BESIII detector at the BEPCII collider. We measure the branching fractions B(Ds+→η'X)=(8.8±1.8±0.5)% and B(Ds+→η'ρ+)=(5.8±1.4±0.4)% where the first uncertainty is statistical and the second is systematic. In addition, we estimate an upper limit on the non-resonant branching ratio B(Ds+→η'π+π0)<5.1% at the 90% confidence level. Our results are consistent with CLEO's recent measurements and help to resolve the disagreement between the theoretical prediction and CLEO's previous measurement of B(Ds+→η'ρ+)
Near-infrared interferometric observation of the Herbig Ae star HD144432
  with VLTI/AMBER

We study the sub-AU-scale circumstellar environment of the Herbig Ae star
HD144432 with near-infrared (NIR) VLTI/AMBER observations to investigate the
structure of its inner dust disk. The interferometric observations were carried
out with the AMBER instrument in the H and K band. We interpret the measured H-
and K-band visibilities, the near- and mid-infrared visibilities from the
literature, and the SED of HD144432 by using geometric ring models and
ring-shaped temperature-gradient disk models with power-law temperature
distributions. We derived a K-band ring-fit radius of 0.17 \pm 0.01 AU and an
H-band radius of 0.18 \pm 0.01 AU (for a distance of 145 pc). This measured
K-band radius of \sim0.17 AU lies in the range between the dust sublimation
radius of \sim0.13 AU (predicted for a dust sublimation temperature of 1500 K
and gray dust) and the prediction of models including backwarming (\sim0.27
AU). We found that an additional extended halo component is required in both
the geometric and temperature-gradient modeling. In the best temperature-
gradient model, the disk consists of two components. The inner part of the disk
is a thin ring with an inner radius of \sim0.21 AU, a temperature of \sim1600
K, and a ring thickness \sim0.02 AU. The outer part extends from \sim1 AU to
\sim10 AU with an inner temperature of \sim400 K. We find that the disk is
nearly face-on with an inclination angle of < 28 degree. Our
temperature-gradient modeling suggests that the NIR excess is dominated by
emission from a narrow, bright rim located at the dust sublimation radius,
while an extended halo component contributes \sim6% to the total flux at 2
{\mu}m. The MIR model emission has a two-component structure with \sim20% flux
from the inner ring and the rest from the outer part. This two-component
structure suggests a disk gap, which is possibly caused by the shadow of a
puffed-up inner rim.Comment: 7 pages, 5 figures, accepted by A&
Freeze-out radii extracted from three-pion cumulantsin pp, p–Pb andPb–Pb collisions at the LHC

International audienceIn high-energy collisions, the spatio-temporal size of the particle production region can be measured using the Bose–Einstein correlations of identical bosons at low relative momentum. The source radii are typically extracted using two-pion correlations, and characterize the system at the last stage of interaction, called kinetic freeze-out. In low-multiplicity collisions, unlike in high-multiplicity collisions, two-pion correlations are substantially altered by background correlations, e.g. mini-jets. Such correlations can be suppressed using three-pion cumulant correlations. We present the first measurements of the size of the system at freeze-out extracted from three-pion cumulant correlations in pp, p–Pb and Pb–Pb collisions at the LHC with ALICE. At similar multiplicity, the invariant radii extracted in p–Pb collisions are found to be 5–15% larger than those in pp, while those in Pb–Pb are 35–55% larger than those in p–Pb. Our measurements disfavor models which incorporate substantially stronger collective expansion in p–Pb as compared to pp collisions at similar multiplicity. (http://creativecommons.org/licenses/by/3.0/). Funded by SCOAP 3
Polarized cosmic microwave background map recovery   with sparse component separation

We used the Healpix software (Gorski et al. 2005) and the iSAP software (http://www.cosmostat.org/software/isap/)International audienceThe polarization modes of the cosmological microwave background are an invaluable source of information for cosmology and a unique window to probe the energy scale of inflation. Extracting this information from microwave surveys requires distinguishing between foreground emissions and the cosmological signal, which means solving a component separation problem. Component separation techniques have been widely studied for the recovery of cosmic microwave background (CMB) temperature anisotropies, but very rarely for the polarization modes. In this case, most component separation techniques make use of second-order statistics to distinguish between the various components. More recent methods, which instead emphasize the sparsity of the components in the wavelet domain, have been shown to provide low-foreground, full-sky estimates of the CMB temperature anisotropies. Building on sparsity, we here introduce a new component separation technique dubbed the polarized generalized morphological component analysis (PolGMCA), which refines previous work to specifically work on the estimation of the polarized CMB maps: i) it benefits from a recently introduced sparsity-based mechanism to cope with partially correlated components; ii) it builds upon estimator aggregation techniques to further yield a better noise contamination/non-Gaussian foreground residual trade-off. The PolGMCA algorithm is evaluated on simulations of full-sky polarized microwave sky simulations using the Planck Sky Model (PSM). The simulations show that the proposed method achieves a precise recovery of the CMB map in polarization with low-noise and foreground contamination residuals. It provides improvements over standard methods, especially on the Galactic center, where estimating the CMB is challenging
Large scale IRAM 30 m CO-observations  in the giant molecular cloud complex W43

International audienceWe aim to fully describe the distribution and location of dense molecular clouds in the giant molecular cloud complex W43. It was previously identified as one of the most massive star-forming regions in our Galaxy. To trace the moderately dense molecular clouds in the W43 region, we initiated W43-HERO, a large program using the IRAM 30 m telescope, which covers a wide dynamic range of scales from 0.3 to 140 pc. We obtained on-the-fly-maps in 13CO (2–1) and C18O (2–1) with a high spectral resolution of 0.1 km s-1 and a spatial resolution of 12′′. These maps cover an area of ~1.5 square degrees and include the two main clouds of W43 and the lower density gas surrounding them. A comparison to Galactic models and previous distance calculations confirms the location of W43 near the tangential point of the Scutum arm at approximately 6 kpc from the Sun. The resulting intensity cubes of the observed region are separated into subcubes, which are centered on single clouds and then analyzed in detail. The optical depth, excitation temperature, and H2 column density maps are derived out of the 13CO and C18O data. These results are then compared to those derived from Herschel dust maps. The mass of a typical cloud is several 104   M⊙ while the total mass in the dense molecular gas (>102 cm-3) in W43 is found to be ~1.9 × 106   M⊙. Probability distribution functions obtained from column density maps derived from molecular line data and Herschel imaging show a log-normal distribution for low column densities and a power-law tail for high densities. A flatter slope for the molecular line data probability distribution function may imply that those selectively show the gravitationally collapsing gas
Modelling weathering processes at the catchment scale: The WITCH numerical model

International audienceA numerical model of chemical weathering in soil horizons and underlying bedrock (WITCH) has been coupled to a numerical model of water and carbon cycles in forest ecosystems (ASPECTS) to simulate the concentration of major species within the soil horizons and the stream of the Strengbach granitic watershed, located in the Vosges Mountains (France). For the first time, simulations of solute con- centrations in soil layers and in the catchment river have been performed on a seasonal basis. The model is able to reproduce the con- centrations of most major species within the soil horizons, as well as catching the first-order seasonal fluctuations of aqueous calcium, magnesium and silica concentrations. However, the WITCH model underestimates concentrations of Mg2+ and silica at the spring of the catchment stream, and significantly underestimates Ca2+ concentration. The deficit in calculated calcium can be compensated for by dis- solution of trace apatite disseminated in the bedrock. However, the resulting increased Ca2+ release yields important smectite precipi- tation in the deepest model layer (in contact with the bedrock) and subsequent removal of large amount of silica and magnesium from solution. In contrast, the model accurately accounts for the concentrations of major species (Ca, Mg and silica) measured in the catchment stream when precipitation of clay minerals is not allowed. The model underestimation of Mg2+ and H4SiO4 concentrations when precipitation of well crystallized smectites is allowed strongly suggests that precipitation of well crystallized clay minerals is over- estimated and that more soluble poorly crystallized and amorphous materials may be forming. In agreement with observations on other watersheds draining granitic rocks, this study indicates that highly soluble trace calcic phases control the aqueous calcium budget in the Strengbach watershed
Search for baryon number violation in top quark decays

A search for baryon number violation (BNV) in top-quark decays is performed using pp collisions produced by the LHC at View the MathML source. The top-quark decay considered in this search results in one light lepton (muon or electron), two jets, but no neutrino in the final state. Data used for the analysis were collected by the CMS detector and correspond to an integrated luminosity of 19.5 fb−1. The event selection is optimized for top quarks produced in pairs, with one undergoing the BNV decay and the other the standard model hadronic decay to three jets. No significant excess of events over the expected yield from standard model processes is observed. The upper limits at 95% confidence level on the branching fraction of the BNV top-quark decay are calculated to be 0.0016 and 0.0017 for the muon and the electron channels, respectively. Assuming lepton universality, an upper limit of 0.0015 results from the combination of the two channels. These limits are the first that have been obtained on a BNV process involving the top quark
Correlations between jets and charged particles in PbPb and pp collisions at sqrt(s_NN) = 2.76 TeV

The quark-gluon plasma is studied via medium-induced changes to correlations between jets and charged particles in PbPb collisions compared to pp reference data. This analysis uses data sets from PbPb and pp collisions with integrated luminosities of 166 μb−1 and 5.3 pb−1, respectively, collected at sNN−−−√=2.76 TeV. The angular distributions of charged particles are studied as a function of relative pseudorapidity (Δη) and relative azimuthal angle (Δϕ) with respect to reconstructed jet directions. Charged particles are correlated with all jets with transverse momentum (p T) above 120 GeV, and with the leading and subleading jets (the highest and second-highest in p T, respectively) in a selection of back-to-back dijet events. Modifications in PbPb data relative to pp reference data are characterized as a function of PbPb collision centrality and charged particle p T. A centrality-dependent excess of low-p T particles is present for all jets studied, and is most pronounced in the most central events. This excess of low-p T particles follows a Gaussian-like distribution around the jet axis, and extends to large relative angles of Δη ≈ 1 and Δϕ ≈ 1
FIRST NuSTAR OBSERVATIONS of MRK 501 WITHIN A RADIO to TeV MULTI-INSTRUMENT CAMPAIGN

We report on simultaneous broadband observations of the TeV-emitting blazar Markarian 501 between 2013 April 1 and August 10, including the first detailed characterization of the synchrotron peak with Swift and NuSTAR. During the campaign, the nearby BL Lac object was observed in both a quiescent and an elevated state. The broadband campaign includes observations with NuSTAR, MAGIC, VERITAS, the Fermi Large Area Telescope, Swift X-ray Telescope and UV Optical Telescope, various ground-based optical instruments, including the GASP-WEBT program, as well as radio observations by OVRO, Metsähovi, and the F-Gamma consortium. Some of the MAGIC observations were affected by a sand layer from the Saharan desert, and had to be corrected using event-by-event corrections derived with a Light Detection and Ranging (LIDAR) facility. This is the first time that LIDAR information is used to produce a physics result with Cherenkov Telescope data taken during adverse atmospheric conditions, and hence sets a precedent for the current and future ground-based gamma-ray instruments. The NuSTAR instrument provides unprecedented sensitivity in hard X-rays, showing the source to display a spectral energy distribution (SED) between 3 and 79 keV consistent with a log-parabolic spectrum and hard X-ray variability on hour timescales. None (of the four extended NuSTAR observations) show evidence of the onset of inverse-Compton emission at hard X-ray energies. We apply a single-zone equilibrium synchrotron self-Compton (SSC) model to five simultaneous broadband SEDs. We find that the SSC model can reproduce the observed broadband states through a decrease in the magnetic field strength coinciding with an increase in the luminosity and hardness of the relativistic leptons responsible for the high-energy emission
Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy.

Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease caused by an abnormal expansion of a tandem CAG repeat in exon 1 of the androgen receptor (AR) gene that results in an abnormally long polyglutamine tract (polyQ) in the AR protein. As a result, the mutant AR (ARpolyQ) misfolds, forming cytoplasmic and nuclear aggregates in the affected neurons. Neurotoxicity only appears to be associated with the formation of nuclear aggregates. Thus, improved ARpolyQ cytoplasmic clearance, which indirectly decreases ARpolyQ nuclear accumulation, has beneficial effects on affected motoneurons. In addition, increased ARpolyQ clearance contributes to maintenance of motoneuron proteostasis and viability, preventing the blockage of the proteasome and autophagy pathways that might play a role in the neuropathy in SBMA. The expression of heat shock protein B8 (HspB8), a member of the small heat shock protein family, is highly induced in surviving motoneurons of patients affected by motoneuron diseases, where it seems to participate in the stress response aimed at cell protection. We report here that HspB8 facilitates the autophagic removal of misfolded aggregating species of ARpolyQ. In addition, though HspB8 does not influence p62 and LC3 (two key autophagic molecules) expression, it does prevent p62 bodies formation, and restores the normal autophagic flux in these cells. Interestingly, trehalose, a well-known autophagy stimulator, induces HspB8 expression, suggesting that HspB8 might act as one of the molecular mediators of the proautophagic activity of trehalose. Collectively, these data support the hypothesis that treatments aimed at restoring a normal autophagic flux that result in the more efficient clearance of mutant ARpolyQ might produce beneficial effects in SBMA patients
Selective glucocorticoid receptor modulation : new directions with non-steroidal scaffolds

Glucocorticoids remain the frontline treatment for inflammatory disorders, yet represent a double-edged sword with beneficial therapeutic actions alongside adverse effects, mainly in metabolic regulation. Considerable efforts were made to improve this balance by attempting to amplify therapeutic beneficial anti-inflammatory actions and to minimize adverse metabolic actions. Most attention has focused on the development of novel compounds favoring the transrepressing actions of the glucocorticoid receptor, assumed to be important for anti-inflammatory actions, over the transactivating actions, assumed to underpin the undesirable actions. These compounds are classified as selective glucocorticoid receptor agonists (SEGRAs) or selective glucocorticoid receptor modulators (SEGRMs). The-latter-class is able to-modulate-the activity of a GR agonist and/or may not classically bind the glucocorticoid receptor ligand-binding pocket. SEGRAs and SEGRMs are collectively denominated SEGRAMs (selective glucocorticoid receptor agonists and modulators). Although this transrepression vs transactivation concept proved to be too simplistic, the developed SEGRAMs were helpful in elucidating various molecular actions of the glucocorticoid receptor, but have also raised many novel questions. We discuss lessons learned from recent mechanistic studies of selective glucocorticoid receptor modulators. This is approached by analyzing recent experimental insights in comparison with knowledge obtained using mutant GR research, thus clarifying the current view on the SEGRAM field. These insights also contribute to our understanding of the processes controlling glucocorticoid-mediated side effects as well as glucocorticoid resistance. Our perspective on non-steroidal SEGRAs and SEGRMs considers remaining opportunities to address research gaps in order to harness the potential for more safe and effective glucocorticoid receptor therapies
Eccentricity and elliptic flow in proton–proton collisions from parton evolution

It has been argued that high-multiplicity proton–proton collisions at the LHC may exhibit collective phenomena usually studied in the context of heavy-ion collisions, such as elliptic flow. We study this issue using DIPSY—a Monte Carlo event generator based on the QCD dipole model. We calculate the eccentricity of the transverse area defined by the spatial distribution of produced gluons. The resulting elliptic flow is estimated to be about 6%, comparable to the value in nucleus–nucleus collisions at RHIC and the LHC. Experimentally, elliptic flow is inferred from the azimuthal correlation between hadrons, which receives contributions from collective flow, and from various other effects referred to as “nonflow”. We discuss how to identify in experiments the signal of flow in the presence of large nonflow effects
Costs and outcomes of increasing access to bariatric surgery for obesity: cohort study and cost-effectiveness analysis using electronic health records

Objectives: To estimate costs and outcomes of increasing access to bariatric surgery (BS) in obese adults and in population sub-groups of gender, age, deprivation, comorbidity and obesity category.  Methods: Cohort study using primary care electronic health records, with linked hospital utilisation data, for 3,045 participants who received BS, and 247,537 participants who did not receive surgery. Epidemiological analyses informed a probabilistic Markov model to compare BS, including equal proportions with adjustable gastric banding, gastric bypass and sleeve gastrectomy, with standard non-surgical management of obesity. Outcomes were quality adjusted life years (QALYs) and net monetary benefits at a threshold of £30,000 per QALY. Results: In a UK population of 250,000 adults, there may be 7,163 people with morbid obesity including 1,406 with diabetes. The immediate cost of 1,000 bariatric surgical procedures is £9.16 million, with incremental discounted lifetime health care costs of £15.26 (95% range £15.18 to 15.36) million. Patient years with diabetes mellitus will decrease by 8,320 (8,123 to 8,502). Incremental quality adjusted life years (QALYs) will increase by 2,142 (2,032 to 2,256). The estimated cost per QALY gained is £7,129 (£6,775 to £7,506). Net monetary benefits will be £49.02 (£45.72 to £52.41) million. Estimates are similar for subgroups of gender, age and deprivation. BS remains cost-effective if the procedure is twice as costly, or if intervention effect declines over time. Conclusions: Diverse obese individuals have capacity to benefit from BS at acceptable cost. BS is not cost-saving but increased health-care costs are exceeded by health benefits to obese individuals