pinecone/core-2020-05-10-deduplication huggingface dataset:
Pion, kaon, proton and anti-proton transverse momentum distributions from p+p and d+Au collisions at sNN=200 GeV

AbstractIdentified mid-rapidity particle spectra of π±, K±, and p(p¯) from 200 GeV p+p and d+Au collisions are reported. A time-of-flight detector based on multi-gap resistive plate chamber technology is used for particle identification. The particle-species dependence of the Cronin effect is observed to be significantly smaller than that at lower energies. The ratio of the nuclear modification factor (RdAu) between protons (p+p¯) and charged hadrons (h) in the transverse momentum range 1.2<pT<3.0 GeV/c is measured to be 1.19±0.05(stat)±0.03(syst) in minimum-bias collisions and shows little centrality dependence. The yield ratio of (p+p¯)/h in minimum-bias d+Au collisions is found to be a factor of 2 lower than that in Au+Au collisions, indicating that the Cronin effect alone is not enough to account for the relative baryon enhancement observed in heavy ion collisions at RHIC
A universal Lagrangian for massive Yang–Mills theories without residual Higgs bosons

AbstractA universal Lagrangian that defines various four-dimensional massive Yang–Mills theories without residual Higgs bosons is presented. Each of the theories is characterized by a constant k contained in the Lagrangian. When k=0, the Lagrangian reduces to the one that defines the topologically massive Yang–Mills theory. When k=1, the Lagrangian reduces to the one that defines the gauged Freedman–Townsend model. New massive Yang–Mills theories are obtained by choosing real numbers other than 0 and 1 to be the constant k
The Protein Interaction Landscape of the Human CMGC Kinase Group

SummaryCellular information processing via reversible protein phosphorylation requires tight control of the localization, activity, and substrate specificity of protein kinases, which to a large extent is accomplished by complex formation with other proteins. Despite their critical role in cellular regulation and pathogenesis, protein interaction information is available for only a subset of the 518 human protein kinases. Here we present a global proteomic analysis of complexes of the human CMGC kinase group. In addition to subgroup-specific functional enrichment and modularity, the identified 652 high-confidence kinase-protein interactions provide a specific biochemical context for many poorly studied CMGC kinases. Furthermore, the analysis revealed a kinase-kinase subnetwork and candidate substrates for CMGC kinases. Finally, the presented interaction proteome uncovered a large set of interactions with proteins genetically linked to a range of human diseases, including cancer, suggesting additional routes for analyzing the role of CMGC kinases in controlling human disease pathways
Mixed Artin–Tate motives over number rings

AbstractThis paper studies Artin–Tate motives over bases S⊂Spec OF, for a number field F. As a subcategory of motives over S, the triangulated category of Artin–Tate motives DATM(S) is generated by motives ϕ∗1(n), where ϕ is any finite map. After establishing the stability of these subcategories under pullback and pushforward along open and closed immersions, a motivic t-structure is constructed. Exactness properties of these functors familiar from perverse sheaves are shown to hold in this context. The cohomological dimension of mixed Artin–Tate motives (MATM(S)) is two, and there is an equivalence DATM(S)≅Db(MATM(S))
Bernstein equiconvergence and Fejér-type theorems for general rational Fourier series

AbstractLet w(θ) be a positive weight function on the interval [−π,π] and associate the positive-definite inner product on the unit circle of the complex plane by〈F,G〉w=12π∫−ππF(eiθ)G(eiθ)w(θ)dθ.For a sequence of points {αk}k=1∞ included in a compact subset of the open unit disk, we consider the orthogonal rational functions (ORF) {φk}k=0∞ that are obtained by orthogonalization of the sequence {1,z/π1,z2/π2,…} where πk(z)=∏j=1k(1−ᾱjz), with respect to this inner product. In this paper we prove that sn(z)−Sn(z) tends to zero in |z|⩽1 if n tends to ∞, where sn is the nth partial sum of the expansion of a bounded analytic function F in terms of the ORF {φk}k=0∞ and Sn is the nth partial sum of the ordinary power series expansion of F. The main condition on the weight is that it satisfies a Dini–Lipschitz condition and that it is bounded away from zero. This generalizes a theorem given by Szegő in the polynomial case, that is when all αk=0. As an important consequence we find that under the above conditions on the weight w and the points {αk}k=1∞, the Cesàro means of the series sn converge uniformly to the function F in |z|⩽1 if the boundary function f(θ)≔F(eiθ) is continuous on [0,2π]. This can be seen as a generalization of Fejér's Theorem
Photonic curing of sol–gel derived HfO2 dielectrics for organic field-effect transistors

AbstractAn efficient way to reduce the supply voltages of organic field-effect transistors is the use of high-k inorganic materials. In order to allow high throughput during fabrication, solution-based processes for realizing inorganic dielectrics by using sol–gel procedures have become attractive in recent years. However, this procedure typically involves extended high-temperature annealing steps to achieve high-quality insulating layers which hampers fast fabrication and is incompatible to be carried out on low-temperature organic substrates. In this work, the use of a photonic curing technique is presented for the annealing of sol–gel derived hafnium oxide (HfO2) dielectrics within a few seconds. The investigations demonstrate the reduction of the leakage current density of more than 3 orders of magnitude after the photonic curing process reaching only slightly higher values as obtained with dielectric films formed from highly sophisticated atomic layer deposition. Moreover, capacitance measurements reveal a dielectric constant of 26 indicating bulk-like properties. Furthermore, organic transistors based on photonically cured HfO2 sol–gel dielectrics are fabricated and characterized operating at low voltages (<2V), low subthreshold swing (110mV/decade) and charge carrier mobilities of 1cm2/Vs using a semiconducting liquid-crystal polymer
Protein-Induced Membrane Curvature Alters Local Membrane Tension

AbstractAdsorption of proteins onto membranes can alter the local membrane curvature. This phenomenon has been observed in biological processes such as endocytosis, tubulation, and vesiculation. However, it is not clear how the local surface properties of the membrane, such as membrane tension, change in response to protein adsorption. In this article, we show that the partial differential equations arising from classical elastic model of lipid membranes, which account for simultaneous changes in shape and membrane tension due to protein adsorption in a local region, cannot be solved for nonaxisymmetric geometries using straightforward numerical techniques; instead, a viscous-elastic formulation is necessary to fully describe the system. Therefore, we develop a viscous-elastic model for inhomogeneous membranes of the Helfrich type. Using the newly available viscous-elastic model, we find that the lipids flow to accommodate changes in membrane curvature during protein adsorption. We show that, at the end of protein adsorption process, the system sustains a residual local tension to balance the difference between the actual mean curvature and the imposed spontaneous curvature. We also show that this change in membrane tension can have a functional impact such as altered response to pulling forces in the presence of proteins
The tectonic and metallogenic framework of Myanmar : a Tethyan mineral system

NJG acknowledges the Oxford University Fell Fund (Ref. DGD07260) and Highland Metals Pte Ltd. for financial support. Analytical support at NIGL was funded through NIGFSC grant IP-1554-0515.Myanmar is perhaps one of the world's most prospective but least explored minerals jurisdictions, containing important known deposits of tin, tungsten, copper, gold, zinc, lead, nickel, silver, jade and gemstones. A scarcity of recent geological mapping available in published form, coupled with an unfavourable political climate, has resulted in the fact that although characterized by several world-class deposits, the nation's mineral resource sector is underdeveloped. As well as representing a potential new search space for a range of commodities, many of Myanmar's known existing mineral deposits remain highly prospective. Myanmar lies at a crucial geologic juncture, immediately south of the Eastern Himalayan Syntaxis, however it remains geologically enigmatic. Its Mesozoic-Recent geological history is dominated by several orogenic events representing the closing of the Tethys Ocean. We present new zircon U-Pb age data related to several styles of mineralization within Myanmar. We outline a tectonic model for Myanmar from the Late Cretaceous onwards, and document nine major mineralization styles representing a range of commodities found within the country. We propose a metallogenetic model that places the genesis of many of these metallotects within the framework of the subduction and suturing of Neo-Tethys and the subsequent Himalayan Orogeny. Temporal overlap of favourable conditions for the formation of particular deposit types during orogenic progression permits the genesis of differing metallotects during the same orogenic event. We suggest the evolution of these favourable conditions and resulting genesis of much of Myanmar's mineral deposits, represents a single, evolving, mineral system: the subduction and suturing of Neo-Tethys.PostprintPeer reviewe
All AdS(7) solutions of type II supergravity

In M-theory, the only AdS(7) supersymmetric solutions are AdS(7) x S-4 and its orbifolds. In this paper, we find and classify new supersymmetric solutions of the type AdS(7) x M-3 in type II supergravity. While in IIB none exist, in IIA with Romans mass (which does not lift to M-theory) there are many new ones. We use a pure spinor approach reminiscent of generalized complex geometry. Without the need for any Ansatz, the system determines uniquely the form of the metric and fluxes, up to solving a system of ODEs. Namely, the metric on M-3 is that of an S-2 fibered over an interval; this is consistent with the Sp(1) R-symmetry of the holographically dual (1,0) theory. By including D8 brane sources, one can numerically obtain regular solutions, where topologically M-3 congruent to S-3
Search for dark matter produced with an energetic jet or a hadronically decaying W or Z boson at sqrt(s) = 13 TeV

A search for dark matter particles is performed using events with large missing transverse momentum, at least one energetic jet, and no leptons, in proton-proton collisions at  s√=13s=13 TeV collected with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 12.9 fb−1. The search includes events with jets from the hadronic decays of a W or Z boson. The data are found to be in agreement with the predicted background contributions from standard model processes. The results are presented in terms of simplified models in which dark matter particles are produced through interactions involving a vector, axial-vector, scalar, or pseudoscalar mediator. Vector and axial-vector mediator particles with masses up to 1.95 TeV, and scalar and pseudoscalar mediator particles with masses up to 100 and 430 GeV respectively, are excluded at 95% confidence level. The results are also interpreted in terms of the invisible decays of the Higgs boson, yielding an observed (expected) 95% confidence level upper limit of 0.44 (0.56) on the corresponding branching fraction. The results of this search provide the strongest constraints on the dark matter pair production cross section through vector and axial-vector mediators at a particle collider. When compared to the direct detection experiments, the limits obtained from this search provide stronger constraints for dark matter masses less than 5, 9, and 550 GeV, assuming vector, scalar, and axial-vector mediators, respectively. The search yields stronger constraints for dark matter masses less than 200 GeV, assuming a pseudoscalar mediator, when compared to the indirect detection results from Fermi-LAT
Cultural and gender convergence in adolescent drunkenness: evidence from 23 European and North American countries.

OBJECTIVE: To investigate time-trend changes in the frequency of drunkenness among European and North American adolescents. DESIGN: Cross-sectional surveys in the 1997/1998 and 2005/2006 Health Behaviour in School-Aged Children Study (HBSC). SETTING: High schools in 23 countries. PARTICIPANTS: A sample of 77 586 adolescents aged 15 years was analyzed by means of hierarchical linear modeling. MAIN OUTCOME MEASURE: The frequency of drunkenness. RESULTS: We observed a significant increase of about 40% in the mean frequency of drunkenness in all 7 participating Eastern European countries. This increase was evident among both genders, but most consistently among girls. Meanwhile, it declined in 13 of 16 Western countries, about 25% on average. Declines in Western countries were particularly notable among boys and in North America, Scandinavia, the United Kingdom, and Ireland. Despite this gender convergence, with few exceptions (Greenland, Norway, United Kingdom) boys continued to have a higher frequency of drunkenness in 2005/2006 than girls. CONCLUSIONS: The confirmed cultural convergence implies that adoption and implementation of evidence-based measures to mitigate the frequency of adolescent drunkenness such as tax increases and restricting alcohol access and advertisement should get the same priority in Eastern European countries as in Western countries. Policy measures that might facilitate decreases in drunkenness such as server training and the promotion of alcohol-free leisure-time activities should be reinforced in Western countries. The gender convergence implies that prevention policy should be less exclusively focused on male adolescents
Student's experiences with traditional bullying and cyberbullying : findings from a Romanian sample

The field of cyberbullying is relatively new and there is no universal consensus on its definition, measurement and intervention. Authors agree that bullying has entered into the digital domain and professionals require the skills to help identify and prevent these behaviours. Ninety two students were surveyed to determine their experience with different types of bullying behaviors (face-to-face, cyberbullying or both), as bully, victim or witness. Our objective was to explore the association between those types of bullying and anxiety. The results suggest a significant association between face-to-face bullying and anxiety. Similarly, there was significant association between experiencing both types of bullying and anxiety. Further studies are required with larger and more diverse samples in order to verify current findings and to test for additional associations
Automation of one-loop QCD computations

We present the complete automation of the computation of one-loop QCD corrections, including UV renormalization, to an arbitrary scattering process in the Standard Model. This is achieved by embedding the OPP integrand reduction technique, as implemented in CutTools, into the MadGraph framework. By interfacing the tool so constructed, which we dub MadLoop, with MadFKS, the fully automatic computation of any infrared-safe observable at the next-to-leading order in QCD is attained. We demonstrate the flexibility and the reach of our method by calculating the production rates for a variety of processes at the 7 TeV LHC
ZD1839 (Gefitinib, 'Iressa'), an epidermal growth factor receptor-tyrosine kinase inhibitor, enhances the anti-cancer effects of TRAIL in human esophageal squamous cell carcinoma

The EGF (epidermal growth factor) receptor-tyrosine kinase inhibitor ZD1839 (Gefitinib, 'Iressa') blocks the cell signaling pathways involved in cell proliferation, survival, and angiogenesis in various cancer cells. TNF-related death apoptosis inducing ligand (TRAIL) acts as an anticancer agent. We investigated the antitumor effects of ZD1839 alone or in combination with TRAIL against human esophageal squamous cell cancer (ESCC) lines. Although all ESCC cells expressed EGF receptor at a protein level, the effect of ZD1839 on cell growth did not correlate with the level of EGFR expression and phosphorylation of EGF receptor protein in ESCC lines. ZD1839 caused a dose-dependent growth arrest at G0–G1 phase associated with increased p27 expression. As TE8 cells are resistant to TRAIL, we tested whether ZD1839 combined with TRAIL induced apoptosis of TE8 cells via the inhibition of EGF receptor signaling by ZD1839. ZD1839 inhibited the phosphorylation of Akt, and enhanced TRAIL-induced apoptosis via activation of caspase-3 and caspase-9, and inactivation of Bcl-xL. Our results indicated that ZD1839 has anti-cancer properties against human esophageal cancer cells. ZD1839 also augmented the anti-cancer activity of TRAIL, even in TRAIL-resistant tumors. These results suggest that treatment with ZD1839 and TRAIL may have potential in the treatment of ESCC patients
Searches for the Z gamma decay mode of the Higgs boson and for new high-mass resonances in pp collisions at root s=13 TeV with the ATLAS detector

This article presents searches for the Zγ decay of the Higgs boson and for narrow high-mass resonances decaying to Zγ, exploiting Z boson decays to pairs of electrons or muons. The data analysis uses 36.1 fb−1 of pp collisions at s√=13 recorded by the ATLAS detector at the CERN Large Hadron Collider. The data are found to be consistent with the expected Standard Model background. The observed (expected — assuming Standard Model pp → H → Zγ production and decay) upper limit on the production cross section times the branching ratio for pp → H → Zγ is 6.6. (5.2) times the Standard Model prediction at the 95% confidence level for a Higgs boson mass of 125.09 GeV. In addition, upper limits are set on the production cross section times the branching ratio as a function of the mass of a narrow resonance between 250 GeV and 2.4 TeV, assuming spin-0 resonances produced via gluon-gluon fusion, and spin-2 resonances produced via gluon-gluon or quark-antiquark initial states. For high-mass spin-0 resonances, the observed (expected) limits vary between 88 fb (61 fb) and 2.8 fb (2.7 fb) for the mass range from 250 GeV to 2.4 TeV at the 95% confidence level
Design and characterisation of advanced pseudo-ductile unidirectional thin-ply carbon/epoxy-glass/epoxy hybrid composites

A comprehensive set of thin-ply pseudo-ductile unidirectional interlayer hybrid composite materials comprising S-glass and a variety of thin carbon prepregs was designed and characterised. Unique elastic-yielding-hardening type stress-strain responses similar to those of ductile metals were achieved through fragmentation and stable pull-out of the carbon layers, generating a range of initial moduli, pseudo-yield strains, plateau stresses and pseudo ductile strains for the various configurations. The typical failure modes of thin-ply hybrid composites were highlighted in four series of stress-strain graphs obtained for the same materials with different carbon layer thicknesses. The predicted failure modes agreed well with the experimental results and demonstrated the merit of our two step design framework based on (i) simple analytical criteria and (ii) novel damage mode maps
Estimation of a significance threshold for epigenome-wide association studies

Epigenome-wide association studies (EWAS) are designed to characterise population-level epigenetic differences across the genome and link them to disease. Most commonly, they assess DNA-methylation status at cytosine-guanine dinucleotide (CpG) sites, using platforms such as the Illumina 450k array that profile a subset of CpGs genome wide. An important challenge in the context of EWAS is determining a significance threshold for declaring a CpG site as differentially methylated, taking multiple testing into account. We used a permutation method to estimate a significance threshold specifically for the 450k array and a simulation extrapolation approach to estimate a genome-wide threshold. These methods were applied to five different EWAS datasets derived from a variety of populations and tissue types. We obtained an estimate of α=2.4×10-7 for the 450k array, and a genome-wide estimate of α=3.6×10-8. We further demonstrate the importance of these results by showing that previously recommended sample sizes for EWAS should be adjusted upwards, requiring samples between ∼10% and ∼20% larger in order to maintain type-1 errors at the desired leve
f-vectors of Minkowski additions of convex polytopes

The objective of this paper is to present two types of   results on Minkowski sums of convex polytopes. The first  is  about a special class of polytopes we call perfectly   centered and the combinatorial properties of the Minkowski   sum with their own dual. In particular, we have a   characterization of the face lattice of the sum in terms  of  the face lattice of a given perfectly centered  polytope.  Exact face counting formulas are then obtained  for  perfectly centered simplices and hypercubes. The  second  type of results concerns tight upper bounds for the  f- vectors of Minkowski sums of several polytopes
Dual Targeting of PDGFR alpha and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors

Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here, we employ an integrated molecular profiling and chemical biology approach to demonstrate that the receptor tyrosine kinases (RTKs) PDGFR alpha and FGFR1 are coactivated in MRT cells and that dual blockade of these receptors has synergistic efficacy. Inhibitor combinations targeting both receptors and the dual inhibitor ponatinib suppress the AKT and ERK1/2 pathways leading to apoptosis. MRT cells that have acquired resistance to the PDGFR alpha inhibitor pazopanib are susceptible to FGFR inhibitors. We show that PDGFR alpha levels are regulated by SMARCB1 expression, and assessment of clinical specimens documents the expression of both PDGFR alpha and FGFR1 in rhabdoid tumor patients. Our findings support a therapeutic approach in cancers with SWI/SNF deficiencies by exploiting RTK coactivation dependencies
Heterogeneous risk and time preferences

Assessing individuals’ time and risk preferences is crucial in domains such as health-related decisions (e.g., dieting, addictions), environmentally-friendly practices, and saving opportunities. We propose a new method to jointly elicit and estimate risk attitudes and intertemporal choices. We use a novel individual level estimation procedure based on a hierarchical Bayes methodology, which can integrate different functional forms for discounting and risk attitudes. This method provides individual level estimates, and allows us to explore the heterogeneity in the data. In addition, we report a negative correlation between risk and time preferences, implying that risk-seeking individuals are less patient and less willing to defer consumption