pinecone/core-2020-05-10-deduplication huggingface dataset:
Pairing in fermion systems with unequal masses: Nonperturbative renormalisation group approach

AbstractThe application of the nonperturbative renormalisation group approach to a system with two fermion species is studied. Assuming a simple ansatz for the effective action with effective bosons, describing pairing effects we derive a set of approximate flow equations for the effective coupling including boson and fermionic fluctuations. The case of two fermions with different masses but coinciding Fermi surfaces is considered. The phase transition to a phase with broken symmetry is found at a critical value of the running scale. The large mass difference is found to disfavour the formation of pairs. The mean-field results are recovered if the effects of boson loops are omitted. While the boson fluctuation effects were found to be negligible for large values of pFa they become increasingly important with decreasing pFa thus making the mean field description less accurate
Defining an 2-disparity Measure to Check and Improve the Geometric Accuracy of Non-interpolating Curved High-order Meshes

AbstractWe define an 2-disparity measure between curved high-order meshes and parameterized manifolds in terms of an 2 norm. The main application of the proposed definition is to measure and improve the distance between a curved high-order mesh and a target parameterized curve or surface. The approach allows considering meshes with the nodes on top of the curve or surface (interpolative), or floating freely in the physical space (non-interpolative). To compute the disparity measure, the average of the squared point-wise differences is minimized in terms of the nodal coordinates of an auxiliary parametric high-order mesh. To improve the accuracy of approximating the target manifold with a non-interpolating curved high-order mesh, we minimize the square of the disparity measure expressed both in terms of the nodal coordinates of the physical and parametric curved high-order meshes. The proposed objective functions are continuously differentiable and thus, we are able to use minimization algorithms that require the first or the second derivatives of the objective function. Finally, we present several examples that show that the proposed methodology generates high-order approximations of the target manifold with optimal convergence rates for the geometric accuracy even when non-uniform parameterizations of the manifolds are prescribed. Accordingly, we can generate coarse curved high-order meshes significantly more accurate than finer low-order meshes that feature the same resolution
Eosinophilic colitis in infants

AbstractObjectiveto review the literature for clinical data on infants with allergic or eosinophilic colitis.Data sourceMEDLINE search of all indexes was performed using the words “colitis or proctocolitis and eosinophilic” or “colitis or proctocolitis and allergic” between 1966 and February of 2013. All articles that described patients’ characteristics were selected.Data synthesisa total of 770 articles were identified, of which 32 met the inclusion criteria. The 32 articles included a total of 314 infants. According to the available information, 61.6% of infants were male and 78.6% were younger than 6 months. Of the 314 patients, 49.0% were fed exclusively breast milk, 44.2% received cow's milk protein, and 6.8% received soy protein. Diarrheal stools were described in 28.3% of patients. Eosinophilia was found in 43.8% (115/263) of infants. Colonic or rectal biopsy showed infiltration by eosinophils (between 5 and 25 per high-power field) in 89.3% (236/264) of patients. Most patients showed improvement with the removal of the protein in cow's milk from their diet or the mother's diet. Allergy challenge tests with cow's milk protein were cited by 12 of the 32 articles (66 patients).Conclusionseosinophilic colitis occurs predominantly in the first six months of life and in males. Allergy to cow's milk was considered the main cause of eosinophilic colitis. Exclusion of cow's milk from the diet of the lactating mother or from the infant's diet is generally an effective therapeutic measure
Membrane-perturbing properties of three peptides corresponding to the ectodomain of hepatitis C virus E2 envelope protein

AbstractBased on the predicted capacity to interact with membranes at the interface, we have found three regions in the ectodomain of the hepatitis C virus envelope glycoprotein E2 (430–449, 543–560 and 603–624) with the ability to destabilize membranes. Three peptides corresponding to the sequence of these regions have been synthesized and their interaction with liposomes have been characterized. The three peptides were able to insert deeply into the hydrophobic core of negatively charged phospholipids as stated by fluorescence depolarization of the probe 1,6-diphenyl-1,3,5-hexatriene. Peptides E2430–449 and E2603–624 were able to induce aggregation of phosphatidylglycerol vesicles in a concentration-dependent manner both at neutral and acidic pH while peptide E2543–560 did not induce any increase of optical density at 360 nm in the concentration range studied. The three peptides induced lipid mixing and the release of the internal contents in a dose-dependent manner when acidic phospholipids were used. Fourier transformed infrared spectroscopy indicated that the peptides adopted mainly a β-sheet conformation which is not modified by the presence of acidic phospholipids. Taken together, our results point out to the involvement of these three regions in the fusion mechanism of HCV at the plasma membrane level
Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a reactive metabolite generated through cytochromes P450. Depending of their nature and their severity, the mitochondrial alterations are able to induce mild to fulminant hepatic cytolysis and steatosis (lipid accumulation), which can have different clinical and pathological features. Microvesicular steatosis, a potentially severe liver lesion usually associated with liver failure and profound hypoglycemia, is due to a major inhibition of mitochondrial fatty acid oxidation (FAO). Macrovacuolar steatosis, a relatively benign liver lesion in the short term, can be induced not only by a moderate reduction of mitochondrial FAO but also by an increased hepatic de novo lipid synthesis and a decreased secretion of VLDL-associated triglycerides. Moreover, recent investigations suggest that some drugs could favor lipid deposition in the liver through primary alterations of white adipose tissue (WAT) homeostasis. If the treatment is not interrupted, steatosis can evolve toward steatohepatitis, which is characterized not only by lipid accumulation but also by necroinflammation and fibrosis. Although the mechanisms involved in this aggravation are not fully characterized, it appears that overproduction of reactive oxygen species by the damaged mitochondria could play a salient role. Numerous factors could favor drug-induced mitochondrial and metabolic toxicity, such as the structure of the parent molecule, genetic predispositions (in particular those involving mitochondrial enzymes), alcohol intoxication, hepatitis virus C infection, and obesity. In obese and diabetic patients, some drugs may induce acute liver injury more frequently while others may worsen the pre-existent steatosis (or steatohepatitis)
Simulation of High Precision Process Control for Set-up Dominant Processes

AbstractThe main focus of this paper is to use discrete-event simulation models, to test the robustness of two process control methods against processes with different statistical distributions. The two methods under scrutiny are the Small-Batch  & R chart and the Set-Up Process Algorithm (SUPA). These have been developed for ‘setup dominant processes’, were the major source of product variation is detected between batches. Minimizing this type of variation is critical to ensure spare parts produced at a later date will fit in operating assemblies, maintaining a Through-life Engineering Service. This paper shows their suitability to industry
‘Snorkel’ sea lice barrier technology reduces sea lice loads on harvest-sized Atlantic salmon with minimal welfare impacts

AbstractThe infestation of farmed Atlantic salmon (Salmo salar) by ectoparasitic sea lice (Lepeophtheirus salmonis) presents a need for new approaches to parasite control. One option is the use of ‘snorkel’ sea lice barrier technology, which restricts salmon from accessing the surface except via a vertical chamber impermeable to sea lice larvae. This prevents the salmon from swimming at the depths where infective sea lice are most abundant. Before snorkels can be implemented in commercial sea-cages, knowledge is required about their effects on salmon welfare and growth. Here, we installed snorkels of 4m depth into three 12×12×12m3 cages, and recorded the lice infestation of stocked fish along with their growth, behaviour, and snout and fin condition over a 12-week period. Three standard sea-cages were utilised for comparison, and all six cages were stocked with ~3500 salmon (2.3±0.6kg). After 3, 6, 9, and 12weeks, fish in snorkel cages had 65, 24, 43, and 56% lower lice levels than in standard cages, respectively. Salmon in both snorkel and standard cages grew similarly well and we detected little or no adverse effects on fish mortality or welfare. The results indicate that snorkel sea-cage barrier technology provides a promising new tool in parasite management in salmon aquaculture.Statement of relevanceThe ectoparasitic sea louse (L. salmonis) is the key obstacle for further expansion of industrial on-growing of salmon in sea-cages in Norway and Scotland. There is therefore high demand from both the industry and the governments for new environmental friendly technologies that reduce the sea louse problem. Here we demonstrate that snorkel sea cages can be used to control lice loads under the problematic autumn months for high valued slaughter ready salmon without significant adverse effects on fish welfare and fish growth. This study is therefore highly relevant for the Aquaculture journal
Search for t→ch at e+e− linear colliders

AbstractWe study the rare top-quark decay t→ch, where h is a generic Higgs boson, at a linear collider. If kinematically accessible, all models contain this decay at some level due to quark flavor mixing. Some models, such as Model III of the two-Higgs doublet model, have a tree-level top–charm–Higgs coupling, and the branching ratio is close to 0.5%. Others, such as the MSSM, have a coupling induced at one-loop, and can have a branching ratio in the range of 10−5–5×10−4. We find that a linear collider of s=500 GeV and a luminosity of 500 fb−1 will begin to be sensitive to this range of the coupling
Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle

BackgroundThe mechanism underlying nonsevere and severe asthma remains unclear, although it is commonly associated with increased airway smooth muscle (ASM) mass. Long noncoding RNAs (lncRNAs) are known to be important in regulating healthy primary airway smooth muscle cells (ASMCs), whereas changed expression has been observed in CD8 T cells from patients with severe asthma.MethodsPrimary ASMCs were isolated from healthy subjects (n = 9) and patients classified as having nonsevere (n = 9) or severe (n = 9) asthma. ASMCs were exposed to dexamethasone and FCS. mRNA and lncRNA expression was measured by using a microarray and quantitative real-time PCR. Bioinformatic analysis was used to examine relevant biological pathways. Finally, the lncRNA plasmacytoma variant translocation 1 (PVT1) was inhibited by transfection of primary ASMCs with small interfering RNAs, and the effect on ASMC phenotype was examined.ResultsThe mRNA expression profile was significantly different between patient groups after exposure to dexamethasone and FCS, and these were associated with biological pathways that might be relevant to the pathogenesis of asthma, including cellular proliferation and pathways associated with glucocorticoid activity. We also observed a significant change in lncRNA expression, yet the expression of only one lncRNA (PVT1) is decreased in patients with corticosteroid-sensitive nonsevere asthma and increased in patients with corticosteroid-insensitive severe asthma. Subsequent targeting studies demonstrated the importance of this lncRNA in controlling both proliferation and IL-6 release in ASMCs from patients with severe asthma.ConclusionslncRNAs are associated with the aberrant phenotype observed in ASMCs from asthmatic patients. Targeting PVT1 might be effective in reducing airway remodeling in asthmatic patients
Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

SummaryOn the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset
U(1) effective confinement theory from SU(2) restricted gauge theory via the Julia–Toulouse approach

AbstractWe derive a U(1) effective theory of color confinement by applying the so-called Julia–Toulouse approach for defects condensation to the SU(2) restricted gauge theory defined by means of the Cho decomposition of the non-abelian connection. Cho's geometric construction naturally displays the topological degrees of freedom of the theory and can be used to put the Yang–Mills action into an abelianized form under certain conditions. On the other hand, the use of the Julia–Toulouse prescription to deal with the monopole condensation leads to an effective action describing the phase whose dynamics is dominated by the magnetic condensate. The effective theory we found describes the interaction between external electric currents displaying a short-range Yukawa interaction plus a linear confinement term that governs the long distance physics
Fock model and Segal–Bargmann transform for minimal representations of Hermitian Lie groups

AbstractFor any Hermitian Lie group G of tube type we construct a Fock model of its minimal representation. The Fock space is defined on the minimal nilpotent KC-orbit X in pC and the L2-inner product involves a K-Bessel function as density. Here K⊆G is a maximal compact subgroup and gC=kC+pC is a complexified Cartan decomposition. In this realization the space of k-finite vectors consists of holomorphic polynomials on X. The reproducing kernel of the Fock space is calculated explicitly in terms of an I-Bessel function. We further find an explicit formula of a generalized Segal–Bargmann transform which intertwines the Schrödinger and Fock model. Its kernel involves the same I-Bessel function. Using the Segal–Bargmann transform we also determine the integral kernel of the unitary inversion operator in the Schrödinger model which is given by a J-Bessel function
Reduced IL-7 Responsiveness Defined by Signal Transducer and Activator of Transcription 5 Phosphorylation in T Cells May Be a Marker for Increased Risk of Developing Cytomegalovirus Disease in Patients after Hematopoietic Stem Cell Transplantation

AbstractCytomegalovirus (CMV) reactivation may lead to CMV disease associated with high morbidity and mortality in patients after hematopoietic stem cell transplantation (HSCT); the identification of clinically relevant markers may aid in the identification of patients at increased risk for developing CMV-associated complications. We evaluated the phosphorylation of signal transducer and activator of transcription 5 (STAT5) in CD4+ T cells, CD8+ T cells, and TCRγδ T cells in response to stimulation with IL-7 or IL-2 after HSCT by analyzing blood samples taken monthly 1 to 6 months after HSCT. Patients were monitored weekly with a quantitative PCR from the time of engraftment for CMV viral load in whole blood until at least day 100 after HSCT. We identified a correlation between clinical outcome regarding CMV replication and the ability to respond to IL-7 and IL-2 defined by STAT5 phosphorylation (pSTAT5). Patients with recurrent or prolonged CMV replications had significantly lower pSTAT5 upon stimulation of T cells with either IL-7 or IL-2 at time points 1 through 3 than those without CMV replication (P < .05). This was also found after stimulation of CD8+ T cells at time point 2 (P < .05). We conclude that reduced responses to IL-7, reflected by pSTAT5, may represent a clinically relevant functional biomarker for individuals at increased risk for CMV reactivation; our data may also aid in designing better strategies to improve anti-CMV immune responses without increasing the risk of developing graft-versus-host disease
Fréchet derivative for light-like Wilson loops

AbstractWe address the equations of motion for the light-like QCD Wilson exponentials defined in the generalized loop space. We attribute an important class of the infinitesimal shape variations of the rectangular light-like Wilson loops to the Fréchet derivative associated to a diffeomorphism in loop space what enables the derivation of the law of the classically conformal-invariant shape variations. We show explicitly that the Fréchet derivative coincides (at least in the leading perturbative order) with the area differential operator introduced in the previous works. We discuss interesting implications of this result which will allow one to relate the rapidity evolution and ultra-violet evolution of phenomenologically important quantum correlation functions (such as 3-dimensional parton distribution functions) and geometrical properties of the light-like cusped Wilson loops
Analogues containing the paramagnetic amino acid TOAC as substrates for angiotensin I-converting enzyme

AbstractThe angiotensin I-converting enzyme (ACE) converts the decapeptide angiotensin I (Ang I) into angiotensin II by releasing the C-terminal dipeptide. A novel approach combining enzymatic and electron paramagnetic resonance (EPR) studies was developed to determine the enzyme effect on Ang I containing the paramagnetic 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC) at positions 1, 3, 8, and 9. Biological assays indicated that TOAC1-Ang I maintained partly the Ang I activity, and that only this derivative and the TOAC3-Ang I were cleaved by ACE. Quenching of Tyr4 fluorescence by TOAC decreased with increasing distance between both residues, suggesting an overall partially extended structure. However, the local bend known to be imposed by the substituted diglycine TOAC is probably responsible for steric hindrance, not allowing the analogues containing TOAC at positions 8 and 9 to act as substrates. In some cases, although substrates and products differ by only two residues, the difference between their EPR spectral lineshapes allows monitoring the enzymatic reaction as a function of time
RuxNb1−xO2 catalyst for the oxygen evolution reaction in proton exchange membrane water electrolysers

AbstractBimetallic catalyst system of ruthenium oxide (RuO2) and niobium oxide (Nb2O5) was prepared using the Adams method and the hydrolysis method. Physical and electrochemical characterizations of the catalysts were studied using X-ray diffraction (XRD), Scanning electron microscopy (SEM), cyclic voltammogram (CV) and polarization measurements. Nb2O5 addition to RuO2 was found to increase the stability of RuO2. In Adams method the sodium nitrate was found to be forming complex with Nb2O5 at high temperature reaction. This makes Adams method unsuitable for the synthesis of RuO2–Nb2O5 bimetallic system. Hydrolysis method on other hand does not have this problem. But a proper mixture of two oxides was not obtained in hydrolysis method. A lower crystallite size for bimetallic system was obtained with Adams method compared to hydrolysis method. RuO2 prepared by Adams method had higher activity compared to the hydrolysis counterpart in electrolyzer operation with nafion membrane. A cell voltage of 1.62 V was obtained with RuO2 (A) at 1 A/cm2. A higher stability for Ru0.8Nb0.2O2(A) compared to RuO2(A) was observed in continuous cyclic voltammogram and electrolyzer cell test
Quantum periods of Calabi–Yau fourfolds

AbstractIn this work we study the quantum periods together with their Picard–Fuchs differential equations of Calabi–Yau fourfolds. In contrast to Calabi–Yau threefolds, we argue that the large volume points of Calabi–Yau fourfolds generically are regular singular points of the Picard–Fuchs operators of non-maximally unipotent monodromy. We demonstrate this property in explicit examples of Calabi–Yau fourfolds with a single Kähler modulus. For these examples we construct integral quantum periods and study their global properties in the quantum Kähler moduli space with the help of numerical analytic continuation techniques. Furthermore, we determine their genus zero Gromov–Witten invariants, their Klemm–Pandharipande meeting invariants, and their genus one BPS invariants. In our computations we emphasize the features attributed to the non-maximally unipotent monodromy property. For instance, it implies the existence of integral quantum periods that at large volume are purely worldsheet instanton generated. To verify our results, we also present intersection theory techniques to enumerate lines with a marked point on complete intersection Calabi–Yau fourfolds in Grassmannian varieties
On the long time behavior of non-autonomous Lotka–Volterra models with diffusion via the sub-supertrajectory method

AbstractIn this paper we study in detail the geometrical structure of global pullback and forwards attractors associated to non-autonomous Lotka–Volterra systems in all the three cases of competition, symbiosis or prey–predator. In particular, under some conditions on the parameters, we prove the existence of a unique nondegenerate global solution for these models, which attracts any other complete bounded trajectory. Thus, we generalize the existence of a unique strictly positive stable (stationary) solution from the autonomous case and we extend to Lotka–Volterra systems the result for scalar logistic equations. To this end we present the sub-supertrajectory tool as a generalization of the now classical sub-supersolution method. In particular, we also conclude pullback and forwards permanence for the above models