pinecone/core-2020-05-10-deduplication huggingface dataset:
Spatial and temporal seasonal trends in coastal upwelling off Northwest Africa, 1981–2012

AbstractSeasonal coastal upwelling was analyzed along the NW African coastline (11–35°N) from 1981 to 2012. Upwelling magnitudes are calculated by wind speed indices, sea-surface temperature indices and inferred from meteorological station, sea-surface height and vertical water column transport data. A permanent annual upwelling regime is documented across 21–35°N and a seasonal regime across 12–19°N, in accordance with the climatology of previous studies. Upwelling regions were split into three zones: (1) the Mauritania–Senegalese upwelling zone (12–19°N), (2) the strong permanent annual upwelling zone (21–26°N) and (3) the weak permanent upwelling zone (26–35°N). We find compelling evidence in our various indices for the Bakun upwelling intensification hypothesis due to a significant coastal summer wind speed increase, resulting in an increase in upwelling-favorable wind speeds north of 20°N and an increase in downwelling-favorable winds south of 20°N. The North Atlantic Oscillation plays a leading role in modifying interannual variability during the other seasons (autumn–spring), with its influence dominating in winter. The East Atlantic pattern shows a strong correlation with upwelling during spring, while El Niño Southern Oscillation and Atlantic Multi-decadal Oscillation teleconnections were not found. A disagreement between observationally-based wind speed products and reanalysis-derived data is explored. A modification to the Bakun upwelling intensification hypothesis for NW Africa is presented, which accounts for the latitudinal divide in summer wind regimes
Brain structural, functional, and cognitive correlates of recent versus remote autobiographical memories in amnestic Mild Cognitive Impairment

AbstractDeficits in autobiographical memory appear earlier for recent than for remote life periods over the course of Alzheimer's disease (AD). The present study aims to further our understanding of this graded effect by investigating the cognitive and neural substrates of recent versus remote autobiographical memories in patients with amnestic Mild Cognitive Impairment (aMCI) thanks to an autobiographical fluency task. 20 aMCI patients and 25 Healthy elderly Controls (HC) underwent neuropsychological tests assessing remote (20-to-30 years old) and recent (the ten last years) autobiographical memory as well as episodic and semantic memory, executive function and global cognition. All patients also had a structural MRI and an FDG-PET scan. Correlations were assessed between each autobiographical memory score and the other tests as well as grey matter volume and metabolism. Within the aMCI, performances for the remote period correlated with personal semantic memory and episodic memory retrieval whereas performances for the recent period only correlated with episodic memory retrieval. Neuroimaging analyses revealed significant correlations between performances for the remote period and temporal pole and temporo-parietal cortex volumes and anterior cingulate gyrus metabolism, while performances for the recent period correlated with hippocampal volume and posterior cingulate, medial prefrontal and hippocampus metabolism. The brain regions related with the retrieval of events from the recent period showed greater atrophy/hypometabolism in aMCI patients compared to HC than those involved in remote memories. Recall of recent memories essentially relies on episodic memory processes and brain network while remote memories also involve other processes such as semantic memory. This is consistent with the semanticization of memories with time and may explain the better resistance of remote memory in AD
The phase structure of the Polyakov–quark–meson model beyond mean field

AbstractThe Polyakov-extended quark–meson model (PQM) is investigated beyond mean-field. This represents an important step towards a fully dynamical QCD computation. Both the quantum fluctuations to the matter sector and the back-reaction of the matter fluctuations to the QCD Yang–Mills sector are included. Results on the chiral and confinement–deconfinement crossover/phase transition lines and the location of a possible critical endpoint are presented. Moreover, thermodynamic quantities such as the pressure and the quark density are discussed
Measuring segregation using patterns of daily travel behavior: A social interaction based model of exposure

AbstractRecent advances in transportation geography demonstrate the ability to compute a metropolitan scale metric of social interaction opportunities based on the time-geographic concept of joint accessibility. The method we put forward in this article decomposes the social interaction potential (SIP) metric into interactions within and between social groups, such as people of different race, income level, and occupation. This provides a novel metric of exposure, one of the fundamental spatial dimensions of segregation. In particular, the SIP metric is disaggregated into measures of inter-group and intra-group exposure. While activity spaces have been used to measure exposure in the geographic literature, these approaches do not adequately represent the dynamic nature of the target populations. We make the next step by representing both the source and target population groups by space–time prisms, thus more accurately representing spatial and temporal dynamics and constraints. Additionally, decomposition of the SIP metric means that each of the group-wise components of the SIP metric can be represented at zones of residence, workplace, and specific origin–destination pairs. Consequently, the spatial variation in segregation can be explored and hotspots of segregation and integration potential can be identified. The proposed approach is demonstrated for synthetic cities with different population distributions and daily commute flow characteristics, as well as for a case study of the Detroit–Warren–Livonia MSA
Polymorphous low-grade adenocarcinoma of the upper lip: 11 cases of an uncommon diagnosis

ObjectiveThe aim of this case study was to describe an international case series of polymorphous low-grade adenocarcinoma (PLGA) affecting the upper lip.Material and MethodsOver a 30-year-period, the files of five pathology services were reviewed for PLGA affecting the upper lip. Hematoxylin and eosin–stained slides were reviewed by three oral and maxillofacial pathologists, and microscopic features were described. Clinical data were retrieved from patients' medical records.ResultsThe review identified 11 cases of upper lip PLGAs, with a complete set of clinical data available for 5 cases. There was a male predominance (1.2:1), and the mean age was 58.7 years. Most cases presented as small asymptomatic swellings that resembled benign tumors. All patients underwent surgery, and no recurrences or metastases were reported in the 8 cases from which follow-up data were available. Microscopically, the typical polymorphic architectural arrangement of PLGA was seen in all cases, with lobular, trabecular, papillary, and cribriform patterns identified. Perineural invasion, normal gland entrapment, Indian filing, and concentric growth were frequently identified.ConclusionPLGA must be included in the list of differential diagnoses of tumors affecting the upper lip because of its similar clinical presentation to benign entities. The follow-up data available from 8 of 11 cases suggest that these tumors follow a low-grade clinical course, similar to the majority of palatal cases of PLGA
Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain — Interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis

AbstractThe purpose of this study was to relate central inflammation to autonomic activity (heart rate variability (HRV)) in patients with rheumatoid arthritis (RA) and fibromyalgia (FM). RA patients had reduced parasympathetic activity and FM patients had increased sympathetic activity compared to healthy controls. Comparisons between RA and FM showed higher cerebrospinal fluid (CSF) interleukin (IL)-1β inversely correlated to parasympathetic activity in RA. The FM patients had higher concentrations of CSF IL-8, IL-1Ra, IL-4 and IL-10, but none of these cytokines correlated with HRV. In conclusion, we found different profiles of central cytokines, i.e., elevated IL-1β in inflammatory pain (RA) and elevated IL-8 in dysfunctional pain (FM)
Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse

SummaryNeuronal nitric oxide synthase (nNOS) is broadly expressed in the brain and associated with synaptic plasticity through NMDAR-mediated calcium influx. However, its physiological activation and the mechanisms by which nitric oxide (NO) influences synaptic transmission have proved elusive. Here, we exploit the unique input-specificity of the calyx of Held to characterize NO modulation at this glutamatergic synapse in the auditory pathway. NO is generated in an activity-dependent manner by MNTB principal neurons receiving a calyceal synaptic input. It acts in the target neuron and adjacent inactive neurons to modulate excitability and synaptic efficacy, inhibiting postsynaptic Kv3 potassium currents (via phosphorylation), reducing EPSCs and so increasing action potential duration and reducing transmission fidelity. We conclude that NO serves as a volume transmitter and slow dynamic modulator, integrating spontaneous and evoked neuronal firing, thereby providing an index of global activity and regulating information transmission across a population of active and inactive neurons
A review and analysis of renewable energy curtailment schemes and Principles of Access: Transitioning towards business as usual

AbstractIn the last decade, the EU has driven forward the development and connection of renewable power sources across Europe. This has changed the way in which distribution networks operate, moving from a passive system, to a more active system where generation and demand are located closer together with system states being more complex and variable. Increased penetration of renewable generation into distribution networks is presenting a number of challenges to Distribution Network Operators (DNOs) including the provision of network access in capacity constrained networks. The introduction of Active Network Management (ANM) is enabling an increase in renewable generation connections through enhanced network access in otherwise ‘full’ networks.This paper presents a way in which DNOs might move towards Business as Usual (BAU) arrangements for ANM schemes. It is necessary to determine the curtailment arrangements, or Principles of Access (PoA), and from this estimate generation access under ANM and the flow of services and money for different scenarios. In this paper, a comprehensive literature review, detailed case study evaluation on early ANM schemes, quantitative curtailment assessment for different PoA and a qualitative analysis of business models for different ANM PoA is presented in turn with conclusions drawn from these three approaches
Diversity and internationalisation in interprofessional education

AbstractThis position paper considers the perspectives regarding introducing diversity and internationalisation to the interprofessional education (IPE) curriculum. While this step may seem to be an onerous task in the challenging area of delivering quality IPE, the author seeks to demonstrate that the diversification of topics, disciplines and geographical locations can provide valuable student learning. By challenging the notion that IPE focusses on health-related topics alone and by broadening students' education, attributes can be developed that enhance employability and address global issues for a skilled workforce capable of delivering complex care. The paper highlights interprofessional educational initiatives developed by the author that includes the introduction of such topics as arts and humanities and public protection, as well as diversification of such disciplines as hospitality management, graphic design and the police. The international initiatives included collaborations between students and staff from Scotland, Japan and Australia. The importance of promoting diversity in the interprofessional curriculum for health and social care students concurs with the strategies from the World Health Organisation's global workforce alliance and professional bodies, such as the Higher Education Academy (UK).This paper encourages educators to engage with these strategies to acquire international perspectives on professional disciplines, thereby enabling students and faculty to develop a deeper understanding of other countries and cultures. IPE educators can develop curricula to include such initiatives and ensure that tomorrow's workforce has the necessary knowledge and skills to become global professionals. By adopting these transferable initiatives, educators can develop similar interventions appropriate for different cultural contexts
Measuring the Higgs-bottom coupling in weak boson fusion

AbstractWe study Higgs production through weak boson fusion with subsequent decay to bottom quarks. By combining jet substructure techniques and matrix element methods in different limits we motivate this channel as a probe of the bottom-Yukawa interactions in the boosted regime. In particular we ameliorate the “no-go” results of cut-and-count analyses in this channel. After applying a data-driven reconstruction approach we find that the Higgs-bottom coupling can be limited to 0.82<yb/ybSM<1.14 with 600 fb−1
Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model

SummaryDuchenne muscular dystrophy (DMD) remains an intractable genetic disease. Althogh there are several animal models of DMD, there is no human cell model that carries patient-specific DYSTROPHIN mutations. Here, we present a human DMD model using human induced pluripotent stem cells (hiPSCs). Our model reveals concordant disease-related phenotypes with patient-dependent variation, which are partially reversed by genetic and pharmacological approaches. Our “chemical-compound-based” strategy successfully directs hiPSCs into expandable myoblasts, which exhibit a myogenic transcriptional program, forming striated contractile myofibers and participating in muscle regeneration in vivo. DMD-hiPSC-derived myoblasts show disease-related phenotypes with patient-to-patient variability, including aberrant expression of inflammation or immune-response genes and collagens, increased BMP/TGFβ signaling, and reduced fusion competence. Furthermore, by genetic correction and pharmacological “dual-SMAD” inhibition, the DMD-hiPSC-derived myoblasts and genetically corrected isogenic myoblasts form “rescued” multi-nucleated myotubes. In conclusion, our findings demonstrate the feasibility of establishing a human “DMD-in-a-dish” model using hiPSC-based disease modeling
Multiple transition states and roaming in ion–molecule reactions: A phase space perspective

AbstractWe provide a dynamical interpretation of the recently identified ‘roaming’ mechanism for molecular dissociation reactions in terms of geometrical structures in phase space. These are NHIMs (Normally Hyperbolic Invariant Manifolds) and their stable/unstable manifolds that define transition states for ion–molecule association or dissociation reactions. The associated dividing surfaces rigorously define a roaming region of phase space, in which both reactive and non reactive trajectories can be trapped for arbitrarily long times
The univalent Bloch–Landau constant, harmonic symmetry and conformal glueing

AbstractBy modifying a domain first suggested by Ruth Goodman in 1945 and by exploiting the explicit solution by Fedorov of the Pólya–Chebotarev problem in the case of four symmetrically placed points, an improved upper bound for the univalent Bloch–Landau constant is obtained. The domain that leads to this improved bound takes the form of a disk from which some arcs are removed in such a way that the resulting simply connected domain is harmonically symmetric in each arc with respect to the origin. The existence of domains of this type is established using techniques from conformal welding, and some general properties of harmonically symmetric arcs in this setting are established
Electric dipole induced by gravity in fat branes

AbstractIn the fat brane model, also known as the split fermion model, it is assumed that leptons and baryons live in different hypersurfaces of a thick brane in order to explain the proton stability without invoking any symmetry. It turns out that, in the presence of a gravity source M, particles will see different four-dimensional (4D) geometries and hence, from the point of view of 4D-observers, the equivalence principle will be violated. As a consequence, we show that a hydrogen atom in the gravitational field of M will acquire a radial electric dipole. This effect is regulated by the Hamiltonian Hd=−μA⋅δr, which is the gravitational analog of the Stark Hamiltonian, where the electric field is replaced by the tidal acceleration A due to the split of fermions in the brane and the atomic reduced mass μ substitutes the electric charge
Generalized Zee–Babu model with 750 GeV diphoton resonance

AbstractWe propose a generalized Zee–Babu model with a global U(1) B–L symmetry, in which we classify the model in terms of the number of the hypercharge N/2 of the isospin doublet exotic charged fermions. Corresponding to each of the number of N, we need to introduce some multiply charged bosons in order to make the exotic fields decay into the standard model fields. We also discuss the muon anomalous magnetic moment and the diphoton excess depending on N, and we show what kind of models are in favor of these phenomenologies
Measurement of the production of neighbouring jets in lead–lead collisions at sNN=2.76 TeV with the ATLAS detector

AbstractThis Letter presents measurements of correlated production of nearby jets in Pb+Pb collisions at sNN=2.76 TeV using the ATLAS detector at the Large Hadron Collider. The measurement was performed using 0.14 nb−1 of data recorded in 2011. The production of correlated jet pairs was quantified using the rate, RΔR, of “neighbouring” jets that accompany “test” jets within a given range of angular distance, ΔR, in the pseudorapidity–azimuthal angle plane. The jets were measured in the ATLAS calorimeter and were reconstructed using the anti-kt algorithm with radius parameters d=0.2, 0.3, and 0.4. RΔR was measured in different Pb+Pb collision centrality bins, characterized by the total transverse energy measured in the forward calorimeters. A centrality dependence of RΔR is observed for all three jet radii with RΔR found to be lower in central collisions than in peripheral collisions. The ratios formed by the RΔR values in different centrality bins and the values in the 40–80% centrality bin are presented
Simplified models of dark matter with a long-lived co-annihilation partner.

We introduce a new set of simplified models to address the effects of 3-point interactions between the dark matter particle, its dark co-annihilation partner, and the Standard Model degree of freedom, which we take to be the tau lepton. The contributions from dark matter co-annihilation channels are highly relevant for a determination of the correct relic abundance. We investigate these effects as well as the discovery potential for dark matter co-annihilation partners at the LHC. A small mass splitting between the dark matter and its partner is preferred by the co-annihilation mechanism and suggests that the co-annihilation partners may be long-lived (stable or meta-stable) at collider scales. It is argued that such long-lived electrically charged particles can be looked for at the LHC in searches of anomalous charged tracks. This approach and the underlying models provide an alternative/complementarity to the mono-jet and multi-jet based dark matter searches widely used in the context of simplified models with the s-channel mediators. We consider four types of simplified models with different particle spins and coupling structures. Some of these models are manifestly gauge invariant and renormalizable, others would ultimately require a UV completion. These can be realised in terms of supersymmetric models in the neutralino-stau co-annihilation regime, as well as models with extra dimensions or composite models
ALMA reveals starburst-like interstellar medium conditions   in a compact star-forming galaxy at z ~ 2 using [CI] and CO.

We present ALMA detections of the [CI] 1–0, CO J = 3–2, and CO J = 4–3 emission lines, as well as the ALMA band 4 continuum for a compact star-forming galaxy (cSFG) at z = 2.225, 3D-HST GS30274. As is typical for cSFGs, this galaxy has a stellar mass of 1.89 ± 0.47 × 1011M⊙, with a star formation rate (SFR) of 214 ± 44 M⊙ yr-1 putting it on the star-forming “main-sequence”, but with an H-band effective radius of 2.5 kpc, making it much smaller than the bulk of “main-sequence” star-forming galaxies. The intensity ratio of the line detections yield an ISM density (~ 6 × 104 cm-3) and a UV-radiation field (~ 2 × 104G0), similar to the values in local starburst and ultra-luminous infrared galaxy environments. A starburst phase is consistent with the short depletion times (tH2,dep ≤ 140 Myr) we find in 3D-HST GS30274 using three different proxies for the H2 mass ([CI], CO, dust mass). This depletion time is significantly shorter than in more extended SFGs with similar stellar masses and SFRs. Moreover, the gas fraction of 3D-HST GS30274 is smaller than typically found in extended galaxies. We measure the CO and [CI] kinematics and find a FWHM line width of ~ 750 ± 41 km s-1. The CO and [CI] FWHM are consistent with a previously measured Hα FWHM for this source. The line widths are consistent with gravitational motions, suggesting we are seeing a compact molecular gas reservoir. A previous merger event, as suggested by the asymmetric light profile, may be responsible for the compact distribution of gas and has triggered a central starburst event. This event gives rise to the starburst-like ISM properties and short depletion times in 3D-HST GS30274. The centrally located and efficient star formation is quickly building up a dense core of stars, responsible for the compact distribution of stellar light in 3D-HST GS30274
Elemental and isotopic carbon and nitrogen records of organic matter accumulation in a Holocene permafrost peat sequence in the East European Russian Arctic

A peat deposit from the East European Russian Arctic, spanning nearly 10 000 years, was investigated to study soil organic matter degradation using analyses of bulk elemental and stable isotopic compositions and plant macrofossil remains. The peat accumulated initially in a wet fen that was transformed into a peat plateau bog following aggradation of permafrost in the late Holocene (∼2500 cal a BP). Total organic carbon and total nitrogen (N) concentrations are higher in the fen peat than in the moss‐dominated bog peat layers. Layers in the sequence that have lower concentrations of total hydrogen (H) are associated with degraded vascular plant residues. C/N and H/C atomic ratios indicate better preservation of organic matter in peat material dominated by bryophytes as opposed to vascular plants. The presence of permafrost in the peat plateau stage and water‐saturated conditions at the bottom of the fen stage appear to lead to better preservation of organic plant material. δ 15 N values suggest N isotopic fractionation was driven primarily by microbial decomposition whereas differences in δ 13 C values appear to reflect mainly changes in plant assemblages. Positive shifts in both δ 15 N and δ 13 C values coincide with a local change to drier conditions as a result of the onset of permafrost and frost heave of the peat surface. This pattern suggests that permafrost aggradation not only resulted in changes in vegetation but also aerated the underlying fen peat, which enhanced microbial denitrification, causing the observed  15 N‐enrichment. Copyright © 2012 John Wiley & Sons, Ltd