pinecone/core-2020-05-10-deduplication huggingface dataset:
Search for very–high–energy y–ray emission from galactic globular clusters with H.E.S.S

Context. Globular clusters (GCs) are established emitters of high-energy (HE, 100MeV < E < 100 GeV) γ-ray radiation which could originate
from the cumulative emission of the numerous millisecond pulsars (msPSRs) in the clusters’ cores or from inverse Compton (IC) scattering of
relativistic leptons accelerated in the GC environment. These stellar clusters could also constitute a new class of sources in the very-high-energy
(VHE, E > 100 GeV) γ-ray regime, judging from the recent detection of a signal from the direction of Terzan 5 with the H.E.S.S. telescope array.
Aims. To search for VHE γ-ray sources associated with other GCs, and to put constraints on leptonic emission models, we systematically analyzed
the observations towards 15 GCs taken with the H.E.S.S. array of imaging atmospheric Cherenkov telescopes.
Methods. We searched for point-like and extended VHE γ-ray emission from each GC in our sample and also performed a stacking analysis
combining the data from all GCs to investigate the hypothesis of a population of faint emitters. Assuming IC emission as the origin of the VHE
γ-ray signal from the direction of Terzan 5, we calculated the expected γ-ray flux from each of the 15 GCs, based on their number of millisecond
pulsars, their optical brightness and the energy density of background photon fields.
Results. We did not detect significant VHE γ-ray emission from any of the 15 GCs in either of the two analyses. Given the uncertainties related to
the parameter determinations, the obtained flux upper limits allow to rule out the simple IC/msPSR scaling model for NGC6388 and NGC7078.
The upper limits derived from the stacking analyses are factors between 2 and 50 below the flux predicted by the simple leptonic scaling model,
depending on the assumed source extent and the dominant target photon fields. Therefore, Terzan 5 still remains exceptional among all GCs, as
the VHE γ-ray emission either arises from extra-ordinarily efficient leptonic processes, or from a recent catastrophic event, or is even unrelated to
the GC itself.http://www.aanda.org/index.php?option=com_toc&url=/articles/aa/abs/2013/03/contents/contents.htmlhttp://www.aanda.org/http://dx.doi.org/ 10.1051/0004-6361/20122071
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium.

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.OBJECTIVE: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes.\ud
METHODS: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence's of ROA before and after standardization in nine cohort studies. This procedure could only be performed in cohort studies and standardization of SOA definitions was not feasible at this moment.\ud
RESULTS: In this consortium, all studies with SOA phenotypes (knee, hip and hand) used a different definition and/or assessment of OA status. For knee-, hip- and hand ROA five, four and seven different definitions were used, respectively. Different hip ROA definitions do lead to different association results. For example, we showed in the RSI that hip OA defined as "at least definite joint space narrowing (JSN) and one definite osteophyte" was not associated with gender (P =0.22), but defined as "at least one definite osteophyte" was significantly associated with gender (P=3×10(-9)). Therefore, a standardization process was undertaken for ROA definitions. Before standardization a wide range of ROA prevalence's was observed in the nine cohorts studied. After standardization the range in prevalence of knee- and hip ROA was small.\ud
CONCLUSION: Phenotype definitions influence the prevalence of OA and association with clinical variables. ROA phenotypes within the TREAT-OA consortium were standardized to reduce heterogeneity and improve power in future genetics studies
Design and synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N′-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) pyrrole hybrid derivatives : discovery of potent antitubercular agents effective against multidrug-resistant mycobacteria.

Novel pyrroles have been designed, synthesized, and evaluated against mycobacterial strains. The pyrroles have originally been designed as hybrids of the antitubercular drugs BM212 (1) and SQ109 (2), which showed common chemical features with very similar topological distribution. A perfect superposition of the structures of 1 and 2 revealed by computational studies suggested the introduction of bulky substituents at the terminal portion of the pyrrole C3 side chain and the removal of the C5 aryl moiety. Five compounds showed high activity toward Mycobacterium tuberculosis, while 9b and 9c were highly active also against multidrug-resistant clinical isolates. Compound 9c showed low eukaryotic cell toxicity, turning out to be an excellent lead candidate for preclinical trials. In addition, four compounds showed potent inhibition (comparable to that of verapamil) toward the whole-cell drug efflux pump activity of mycobacteria, thus turning out to be promising multidrug-resistance-reversing agents
Cytotoxic responses to 405 nm light exposure in mammalian and bacterial cells : involvement of reactive oxygen species

Light at wavelength 405 nm is an effective bactericide. Previous studies showed that exposing mammalian cells to 405 nm light at 36 J/cm2 (a bactericidal dose) had no significant effect on normal cell function, although at higher doses (54 J/cm2), mammalian cell death became evident. This research demonstrates that mammalian and bacterial cell toxicity induced by 405 nm light exposure is accompanied by reactive oxygen species production, as detected by generation of fluorescence from 6-carboxy-2’,7’- dichlorodihydrofluorescein diacetate. As indicators of the resulting oxidative stress in mammalian cells, a decrease in intracellular reduced glutathione content and a corresponding increase in the efflux of oxidised glutathione was observed from 405 nm light treated cells. The mammalian cells were significantly protected from dying at 54 J/cm2 in the presence of catalase, which detoxifies H2O2. Bacterial cells were significantly protected by sodium pyruvate (H2O2 scavenger) and by a combination of free radical scavengers (sodium pyruvate, dimethyl thiourea (OH scavenger) and catalase) at 162 and 324 J/cm2. Results herefore suggested that the cytotoxic mechanism of 405 nm light in mammalian cells and bacteria could be oxidative stress involving predominantly H2O2 generation, with other ROS contributing to the damage
PAT-based design of agrochemical co-crystallization processes : a case-study for the selective crystallization of 1:1 and 3:2 co-crystals of p-toluenesulfonamide/triphenylphosphine oxide

In this study, the selective crystallization and characterization of the stoichiometric forms of the p-toluenesulfonamide/triphenylphosphine oxide (p-TSA-TPPO) co-crystal system in acetonitrile (MeCN) is demonstrated using batch and semi-batch crystallizers. In the batch study, both 1:1 and 3:2 p-TSA-TPPO were successfully isolated as pure forms. However, process variability was observed in a few experimental runs. To address the batch process variability issue, a control strategy was implemented using temperature cycling, aided by in situ process analytical technologies (PAT) to convert from 3:2 to 1:1 p-TSA-TPPO. In the semi-batch co-crystallization studies, the two molecular co-formers, p-TSA and TPPO, were dissolved in MeCN and pumped separately to the crystallizer. Changing the flow rates of the respective active ingredients allowed control over the co-crystallization outcome, and presents as a promising opportunity for development of a continuous co-crystallization process
Modelling arbitrarily shaped and tightly focused laser pulses in
  electromagnetic codes

Investigation of laser matter interaction with electromagnetic codes requires
to implement sources for the electromagnetic fields. A way to do so is to
prescribe the fields at the numerical box boundaries in order to achieve the
desired fields inside the numerical box. Here we show that the often used
paraxial approximation can lead to unexpected field profiles with strong impact
on the laser matter interaction results. We propose an efficient numerical
algorithm to compute the required laser boundary conditions consistent with the
Maxwell's equations for arbitrarily shaped, tightly focused laser pulses
Measurement of the properties of the $\Xi_b^{*0}$ baryon

We perform a search for near-threshold $\Xi_b^0$ resonances decaying to
$\Xi_b^- \pi^+$ in a sample of proton-proton collision data corresponding to an
integrated luminosity of 3 fb$^{-1}$ collected by the LHCb experiment. We
observe one resonant state, with the following properties:
  \begin{eqnarray*}
  m(\Xi_b^{*0}) - m(\Xi_b^-) - m(\pi^+) &=& 15.727 \pm 0.068 \, (\mathrm{stat})
\pm 0.023 \, (\mathrm{syst}) \, \mathrm{MeV}/c^2,
  \Gamma(\Xi_b^{*0}) &=& 0.90 \pm 0.16 \, (\mathrm{stat}) \pm 0.08 \,
(\mathrm{syst}) \, \mathrm{MeV}
  .
  \end{eqnarray*} This confirms the previous observation by the CMS
collaboration. The state is consistent with the $J^P=3/2^+$ $\Xi_b^{*0}$
resonance expected in the quark model. This is the most precise determination
of the mass and the first measurement of the natural width of this state. We
have also measured the ratio
  \begin{align*} \frac{\sigma(pp \to \Xi_b^{*0} X){\cal{B}}(\Xi_b^{*0} \to
\Xi_b^- \pi^+)}{\sigma(pp \to \Xi_b^- X)}
  = 0.28 \pm 0.03 \, (\mathrm{stat}) \pm 0.01 \, (\mathrm{syst}) . \end{align*}Comment: 19 pages, 5 figures. All figures and tables, along with any
  supplementary material and additional information, are available at
  https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-010.htm
A single-mode external cavity diode laser using an intra-cavity atomic
  Faraday filter with short-term linewidth $<400$ kHz and long-term stability
  of $<1$ MHz

We report on the development of a diode laser system - the `Faraday laser' -
using an atomic Faraday filter as the frequency-selective element. In contrast
to typical external-cavity diode laser systems which offer tunable output
frequency but require additional control systems in order to achieve a stable
output frequency, our system only lases at a single frequency, set by the peak
transmission frequency of the internal atomic Farady filter. Our system has
both short-term and long-term stability of less than 1~MHz, which is less than
the natural linewidth of alkali-atomic D-lines, making similar systems suitable
for use as a `turn-key' solution for laser cooling experiments
Search for high-mass new phenomena in the dilepton final state using
  proton-proton collisions at $\sqrt{s}=13$ TeV with the ATLAS detector

A search is conducted for both resonant and non-resonant high-mass new
phenomena in dielectron and dimuon final states. The search uses 3.2 fb$^{-1}$
of proton-proton collision data, collected at $\sqrt{s} = 13$ TeV by the ATLAS
experiment at the LHC in 2015. The dilepton invariant mass is used as the
discriminating variable. No significant deviation from the Standard Model
prediction is observed; therefore limits are set on the signal model parameters
of interest at 95% credibility level. Upper limits are set on the cross-section
times branching ratio for resonances decaying to dileptons, and the limits are
converted into lower limits on the resonance mass, ranging between 2.74 TeV and
3.36 TeV, depending on the model. Lower limits on the $\ell\ell qq$ contact
interaction scale are set between 16.7 TeV and 25.2 TeV, also depending on the
model.Comment: 18 pages plus author list + cover pages (35 pages total), 4 figures,
  4 tables, published by Phys. Lett. B. All figures, including auxiliary
  figures, are available at
  https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/EXOT-2015-0
Speeding up systems biology simulations of biochemical pathways using condor

This is the accepted version of the following article: Speeding up Systems Biology Simulations of Biochemical Pathways using Condor". Concurrency and Computation: Practice and Experience Volume 26, Issue 17, pages 2727–2742, 10 December 2014 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/cpe.3161/abstractSystems biology is a scientific field that uses computational modelling to study biological and biochemical systems. The simulation and analysis of models of these systems typically explore behaviour over a wide range of parameter values; as such, they are usually characterised by the need for nontrivial amounts of computing power. Grid computing provides access to such computational resources. In previous research, we created the grid-enabled biochemical networks simulation environment to attempt to speed up system biology simulations over a grid (the UK National Grid Service and ScotGrid). Following on from this work, we have created the simulation modelling of the epidermal growth factor receptor microtubule-associated protein kinase pathway utility, a standalone simulation tool dedicated to the modelling and analysis of the epidermal growth factor receptor microtubule-associated protein kinase pathway. This builds on experiences from biochemical networks simulation environment by decoupling the simulation modelling elements from the Grid middleware. This new utility enables us to interface with different grid technologies. This paper therefore describes the new SIMAP utility and an empirical investigation of its performance when deployed over a desktop grid based on the high throughput computing middleware Condor. We present our results based on a case study with a model of the mammalian ErbB signalling pathway, a pathway strongly linked to cance
Fusion of 40Ca + 96Zr revisited: transfer couplings and hindrance far below the barrier

The sub-barrier fusion excitation function of 40Ca+96Zr has been measured down to cross sections 2.4micro b, i.e. two orders of magnitude smaller than obtained in a previous experiment, where the sub-barrier fusion of this system was found to be greatly enhanced with respect to 40Ca + 90Zr, and the need of coupling to transfer channels was suggested relying on coupled-channels calculations. The purpose of this work has been to investigate the behavior of 40Ca + 96Zr fusion far below the barrier, thereby disentangling the elusive interplay of effects due to inelastic couplings, transfer couplings and, possibly, the appearance of the fusion hindrance. The smooth trend of the excitation function has been found to continue, and the logarithmic slope increases very slowly. No indication of hindrance shows up, and a comparison with 48Ca + 96Zr is illuminating in this respect. A new CC analysis of the complete excitation function has been performed, including explicitly one- and two-nucleon Q >0 transfer channels. Such transfer couplings bring significant cross section enhancements, even at the level of a few micro b. Locating the hindrance threshold, if any, in 40Ca + 96Zr would require challenging measurements of cross sections in the sub-micro b range
A Linear Program For Holistic Matching : Assessment on Schema Matching Benchmark

International audienceSchema matching is a key task in several applications such as data  integration and ontology engineering. All application fields require the matching  of several schemes also known as "holistic matching", but the difficulty of the  problem spawned much more attention to pairwise schema matching rather than  the latter. In this paper, we propose a new approach for holistic matching. We  suggest modelling the problem with some techniques borrowed from the combinatorial  optimization field. We propose a linear program, named LP4HM, which  extends the maximum-weighted graph matching problem with different linear  constraints. The latter encompass matching setup constraints, especially cardinality  and threshold constraints; and schema structural constraints, especially superclass/subclass  and coherence constraints. The matching quality of LP4HM is  evaluated on a recent benchmark dedicated to assessing schema matching tools.  Experimentations show competitive results compared to other tools, in particular  for recall and HSR quality measure
O-(β-hydroxyethyl)rutosides determination by micellar flow injection (FI) spectrofluorimetry

A simple, eco friendly, sensitive and economic flow injection spectrofluorimetric method was developed for the determination of O-(β-hydroxyethyl)rutosides. The procedure was based on the use of an anionic surfactant such as sodium dodecyl sulfate to provide an appreciable O-(β-  hydroxyethyl)rutosides fluorescence enhancement, increasing considerably the sensitivity of detection. All the variables affecting the fluorescence intensity were studied and optimized. The flow rate was 5 mL/min with detection at 450 nm (after excitation at 346 nm). A linear correlation between drug amount and peak area was established for O-(β-hydroxyethyl)rutosides in the range of 0.01 - 200 μg/mL with a detection limit of 0.001 μg/mL (s/n = 3). Validation processes were performed by  recovering studies with satisfactory results. The new methodology can be employed for the routine analysis of O-(β-hydroxyethyl)rutosides in bulks as well as in commercial formulations.Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Fisica; ArgentinaFil: Peralta, Cecilia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentin
Large Randall-Sundrum II Black Holes

Using a novel numerical spectral method, we have constructed an AdS_5-CFT_4
solution to the Einstein equation with a negative cosmological constant Lambda
that is asymptotically conformal to the Schwarzschild metric. This method is
independent of the Ricci-DeTurck-flow method used by Figueras, Lucietti, and
Wiseman. We have perturbed the solution to get large static black hole
solutions to the Randall-Sundrum II (RSII) braneworld model. Our solution
agrees closely with that of Figueras et al. and also allows us to deduce the
new results that to first order in 1/(-Lambda M^2), the Hawking temperature and
entropy of an RSII static black hole have the same values as the Schwarzschild
metric with the same mass, but the horizon area is increased by about
4.7/(-Lambda).Comment: 6 pages, 1 figure, revtex4-
Lax matrix solution of c = 1 conformal field theory

International audienceTo a correlation function in a two-dimensional conformal field theory with the central charge c = 1, we associate a matrix differential equation Ψ ′ = LΨ, where the Lax matrix L is a matrix square root of the energy-momentum tensor. Then local conformal symmetry implies that the differential equation is isomonodromic. This provides a justification for the recently observed relation between four-point conformal blocks and solutions of the Painlevé VI equation. This also provides a direct way to compute the three-point function of Runkel-Watts theory – the common c → 1 limit of Minimal Models and Liouville theory
Controling the number of focal elements

International audienceA basic belief assignment can have up to 2n focal elements, and combining them with a simple conjunctive operator will need O(22n ) opera- tions. This article proposes some techniques to limit the size of the focal sets of the bbas to be combined while preserving a large part of the information they carry. The first section revisits some well-known definitions with an algorithmic point of vue. The second section proposes a matrix way of building the least committed isopignistic, and extends it to some other bodies of evidence. The third section adapts the k-means algorithm for an unsupervized clustering of the focal elements of a given bba
Bronchoalveolar lavage causes decrease in PaO2, increase in (A-a) gradient value and bronchoconstriction in asthmatics.

Abstract\ud
The aims of this study were to (1) record the changes of (arterial oxygen partial pressure) PaO2, (arterial carbon dioxide partial pressure) PaCO2, (percentage saturation of haemoglobin with oxygen in arterial blood) SaO2 and alveolar-arterial (A-a) oxygen gradiant resulting from bronchoalveolar lavage (BAL) in asthmatic and normal subjects; (2) measure changes in forced expiratory volume in 1 s (FEV1), vital capacity forced (FVC) associated with BAL; and (3) assess possible predictive factors for the degree of hypoxaemia and impairment of spirometry resulting from BAL. Bronchoscopy and BAL (150 ml) were performed in 24 asthmatics and 15 healthy subjects. Serial arterial blood samples (radial artery) were obtained in all subjects: T1 and before T2 after local anaesthesia; T3 at end of bronchoscopy; T4 after BAL and 5 min, 15 min, 1 h, 2 h, 8 h and 24 h (T5-T10) after the procedure, FEV1 and FVC were measured immediately before and 5 min afer bronchoscopy. Baseline PaO2 was lower in asthmatics (10.2 +/- 0.8 kPa) than in healthy subjects (10.8 +/- 0.8). Both groups showed a significant decrease in PaO2, and a significant widening in (A-a) oxygen tension gradiant at T3-9, with respect to T1 (P < 0.05). PaO2 reached a significantly lower value in asthmatics (7.1 +/- 0.6 kPa) than in HS (7.7 +/- 0.5; P < 0.05). In asthmatics, FEV1, FVC and the ratio FEV1/FVC decreased significantly after BAL (P < 0.001). In healthy subjects, FEV1 and FVC decreased significantly (P < 0.001), whereas FEV1/FVC did not. The fall in FEV1 after BAL was significantly greater in asthmatics (32.4 +/- 10.0%) than in healthy subjects (17.7 +/- 4.6; P < 0.001). Severity of asthma, basline FEV1 or initial PaO2 did not predict the degree of hypoxaemia or the fall of FEV1. It is concluded that BAL causes more severe hypoxaemia and a greater decrease in FEV1 in asthmatics compared to healthy subjects, strongly supporting the recommendation of special caution and careful monitoring when BAL is undertaken in asthmatics
Search for new physics in events with same-sign dileptons and jets in pp collisions at sqrt(s) = 8 TeV

A search for new physics is performed based on events with jets and a pair of isolated, same-sign leptons. The results are obtained using a sample of proton-proton collision data collected by the CMS experiment at a centre-of-mass energy of 8 TeV at the LHC, corresponding to an integrated luminosity of 19.5 fb−1. In order to be sensitive to a wide variety of possible signals beyond the standard model, multiple search regions defined by the missing transverse energy, the hadronic energy, the number of jets and b-quark jets, and the transverse momenta of the leptons in the events are considered. No excess above the standard model background expectation is observed and constraints are set on a number of models for new physics, as well as on the same-sign top-quark pair and quadruple-top-quark production cross sections. Information on event selection efficiencies is also provided, so that the results can be used to confront an even broader class of new physics models