pinecone/core-2020-05-10-deduplication huggingface dataset:
Age-related patterns of vigorous-intensity physical activity in youth : the International Children's Accelerometry database

Physical activity declines during youth but most evidence reports on combined moderate and vigorous-intensity physical activity. We investigated how vigorous-intensity activity varies with age. Cross-sectional data from 24,025 participants (5.0-18.0 y; from 20 studies in 10 countries obtained 2008-2010) providing ≥ 1 day accelerometer data (International Children's Accelerometry Database (ICAD)). Linear regression was used to investigate age-related patterns in vigorous-intensity activity; models included age (exposure), adjustments for monitor wear-time and study. Moderate-intensity activity was examined for comparison. Interactions were used to investigate whether the age/vigorous-activity association differed by sex, weight status, ethnicity, maternal education and region. A 6.9% (95% CI 6.2, 7.5) relative reduction in mean vigorous-intensity activity with every year of age was observed; for moderate activity the relative reduction was 6.0% (5.6%, 6.4%). The age-related decrease in vigorous-intensity activity remained after adjustment for moderate activity. A larger age-related decrease in vigorous activity was observed for girls (- 10.7%) versus boys (- 2.9%), non-white (- 12.9% to - 9.4%) versus white individuals (- 6.1%), lowest maternal education (high school (- 2.0%)) versus college/university (ns) and for overweight/obese (- 6.1%) versus healthy-weight participants (- 8.1%). In addition to larger annual decreases in vigorous-intensity activity, overweight/obese individuals, girls and North Americans had comparatively lower average vigorous-intensity activity at 5.0-5.9 y. Age-related declines in vigorous-intensity activity during youth appear relatively greater than those of moderate activity. However, due to a higher baseline, absolute moderate-intensity activity decreases more than vigorous. Overweight/obese individuals, girls, and North Americans appear especially in need of vigorous-intensity activity promotion due to low levels at 5.0-5.9 y and larger negative annual differences
The prevalence of comorbidities in COPD patients, and their impact on health status and COPD symptoms in primary care patients : a protocol for an UNLOCK study from the IPCRG

Funding The IPCRG provided funding for this research project as an UNLOCK Group study for which the funding was obtained through an unrestricted grant by Novartis AG, Basel, Switzerland. Novartis has no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This study will include data from the Optimum Patient Care Research Database, and is undertaken in collaboration with Optimum Patient Care and the Respiratory Effectiveness Group, which will provide the data for this initiative without charge to the UNLOCK Group.Peer reviewedPublisher PD
Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination.

Inherited retinal dystrophies (iRDs) are a group of genetically and clinically heterogeneous conditions resulting from mutations in over 250 genes. Here, homozygosity mapping and whole-exome sequencing (WES) in a consanguineous family revealed a homozygous missense mutation, c.973C&gt;T (p.His325Tyr), in RCBTB1. In affected individuals, it was found to segregate with retinitis pigmentosa (RP), goiter, primary ovarian insufficiency, and mild intellectual disability. Subsequent analysis of WES data in different cohorts uncovered four additional homozygous missense mutations in five unrelated families in whom iRD segregates with or without syndromic features. Ocular phenotypes ranged from typical RP starting in the second decade to chorioretinal dystrophy with a later age of onset. The five missense mutations affect highly conserved residues either in the sixth repeat of the RCC1 domain or in the BTB1 domain. A founder haplotype was identified for mutation c.919G&gt;A (p.Val307Met), occurring in two families of Mediterranean origin. We showed ubiquitous mRNA expression of RCBTB1 and demonstrated predominant RCBTB1 localization in human inner retina. RCBTB1 was very recently shown to be involved in ubiquitination, more specifically as a CUL3 substrate adaptor. Therefore, the effect on different components of the CUL3 and NFE2L2 (NRF2) pathway was assessed in affected individuals' lymphocytes, revealing decreased mRNA expression of NFE2L2 and several NFE2L2 target genes. In conclusion, our study puts forward mutations in RCBTB1 as a cause of autosomal-recessive non-syndromic and syndromic iRD. Finally, our data support a role for impaired ubiquitination in the pathogenetic mechanism of RCBTB1 mutations
Structural and spectroscopic characterisation of a heme peroxidase from sorghum

A cationic class III peroxidase from Sorghum bicolor was purified to homogeneity. The enzyme contains a high-spin heme, as evidenced by UV-visible spectroscopy and EPR. Steady state oxidation of guaiacol was demonstrated and the enzyme was shown to have higher activity in the presence of calcium ions. A Fe(III)/Fe(II) reduction potential of -266 mV vs NHE was determined. Stopped-flow experiments with H2O2 showed formation of a typical peroxidase Compound I species, which converts to Compound II in the presence of calcium. A crystal structure of the enzyme is reported, the first for a sorghum peroxidase. The structure reveals an active site that is analogous to those for other class I heme peroxidase, and a substrate binding site (assigned as arising from binding of indole-3-acetic acid) at the γ-heme edge. Metal binding sites are observed in the structure on the distal (assigned as a Na(+) ion) and proximal (assigned as a Ca(2+)) sides of the heme, which is consistent with the Ca(2+)-dependence of the steady state and pre-steady state kinetics. It is probably the case that the structural integrity (and, thus, the catalytic activity) of the sorghum enzyme is dependent on metal ion incorporation at these positions.Peer-reviewedPublisher Versio
Search for supersymmetry at √s = 8 TeV in final states with jets and two same-sign leptons or three leptons with the ATLAS detector

A search for strongly produced supersymmetric particles is conducted using signatures involving multiple energetic jets and either two isolated leptons (e or μ) with the same electric charge, or at least three isolated leptons. The search also utilises jets originating from b-quarks, missing transverse momentum and other observables to extend its sensitivity. The analysis uses a data sample corresponding to a total integrated luminosity of 20.3 fb[superscript −1] of √s = 8 TeV proton-proton collisions recorded with the ATLAS detector at the Large Hadron Collider in 2012. No deviation from the Standard Model expectation is observed. New or significantly improved exclusion limits are set on a wide variety of supersymmetric models in which the lightest squark can be of the first, second or third generations, and in which R-parity can be conserved or violated.United States. Dept. of EnergyNational Science Foundation (U.S.)Brookhaven National Laborator
First evidence for the annihilation decay mode B+ → D+ s φ

Abstract: Evidence for the hadronic annihilation decay mode B[superscript +] → D[superscript +][subscript s] φ is found with greater than 3σ significance. The branching fraction and CP asymmetry are measured to be B(B[superscript +] → D[superscript +][subscript s] φ) = 1.87 +1.25
−0.73 (stat) ± 0.19 (syst) ± 0.32 (norm)  × 10[superscript −6], A[subscript CP] (B[superscript +] → D[superscript +][subscript s] φ) = −0.01 ± 0.41 (stat) ± 0.03 (syst). The last uncertainty on B(B[superscript +] → D[superscript +][subscript s] φ) is from the branching fractions of the B[superscript +]→ D[superscript +][subscript s] [bar over D][superscript 0]
normalization mode and intermediate resonance decays. Upper limits are also set for the branching fractions of the related decay modes B
[superscript +][subscript (c)] → D[superscript +][subscript (s)]K[superscript ∗0], B[superscript +][subscript (c)] → D[superscript +][subscript (s)][bar overK][superscript ∗0] and B[superscript +][subscript c] → D[superscript +][subscript s] φ, including the result B(B[superscript +] → D[superscript +]K[superscript ∗0]) < 1.8×10−6 at the 90% credibility level
A measurement of the ratio of the W and Z cross sections with exactly one associated jet in pp collisions at root s = 7 TeV with ATLAS

The ratio of production cross sections of the W and Z bosons with exactly one associated jet is presented as a function of jet transverse momentum threshold. The measurement has been designed to maximise cancellation of experimental and theoretical uncertainties, and is reported both within a particle-level kinematic range corresponding to the detector acceptance and as a total cross-section ratio. Results are obtained with the ATLAS detector at the LHC in pp collisions at a centre-of-mass energy of 7 TeV using an integrated luminosity of 33 pb⁻¹. The results are compared with perturbative leading-order, leading-log, and next-to-leading-order QCD predictions, and are found to agree within experimental and theoretical uncertainties. The ratio is measured for events with a single jet with pτ > 30 GeV to be 8.73 ± 0.30(stat) ± 0.40(syst) in the electron channel, and 8.49 ± 0.23(stat) ± 0.33(syst) in the muon channel.G. Aad ... P. Jackson ... L. Lee ... A. Petridis ... N. Soni ... M.J. White ... et al. (ATLAS Collaboration
Search for heavy resonances decaying to a Z boson and a photon in pp collisions at √s=13 TeV with the ATLAS detector

This Letter presents a search for new resonances with mass larger than 250 GeV, decaying to a Z boson and a photon. The dataset consists of an integrated luminosity of 3.2 fb−1 of pp   collisions collected at √s=13 with the ATLAS detector at the Large Hadron Collider. The Z   bosons are identified through their decays either to charged, light, lepton pairs (e+e−e+e−, μ+μ−μ+μ−) or to hadrons. The data are found to be consistent with the expected background in the whole mass range investigated and upper limits are set on the production cross section times decay branching ratio to Zγ of a narrow scalar boson with mass between 250 GeV and 2.75 TeV
A critical perspective on second-order empathy in understanding psychopathology : phenomenology and ethics

The centenary of Karl Jaspers’ General Psychopathology was recognised
in 2013 with the publication of a volume of essays dedicated to his work
(edited by Stanghellini and Fuchs). Leading phenomenological-psychopathologists
and philosophers of psychiatry examined Jaspers notion of empathic understanding
and his declaration that certain schizophrenic phenomena are ‘un-understandable’.
The consensus reached by the authors was that Jaspers operated with a narrow
conception of phenomenology and empathy and that schizophrenic phenomena can
be understood through what they variously called second-order and radical empathy.
This article offers a critical examination of the second-order empathic stance
along phenomenological and ethical lines. It asks: (1) Is second-order empathy
(phenomenologically) possible? (2) Is the second-order empathic stance an ethically
acceptable attitude towards persons diagnosed with schizophrenia? I argue that
second-order empathy is an incoherent method that cannot be realised. Further, the
attitude promoted by this method is ethically problematic insofar as the emphasis
placed on radical otherness disinvests persons diagnosed with schizophrenia from a
fair chance to participate in the public construction of their identity and, hence, to
redress traditional symbolic injustices.National Research Foundation (UID: 91245)http://link.springer.com/journal/110172016-04-30hb201
Echolucent or predominantly echolucent femoral plaques predict early restenosis after eversion carotid endarterectomy

ObjectiveAlthough the association between vulnerable lesions and cardiovascular events is well established, little is known about their relationship to postsurgery restenosis. To address this issue, we initiated a prospective, nonrandomized study to examine the femoral plaques on both sides in patients who were undergoing eversion carotid endarterectomy (CEA) and were longitudinally followed-up for early restenosis development.MethodsThe final analysis enrolled 321 patients (189 women) with a median age of 67.0 years (interquartile range, 59.0-73.0 years), who underwent eversion CEA (2005 to 2007). Using duplex ultrasound scanning, we evaluated 321 common femoral atherosclerotic lesions on the day before CEA. A quantitative scale was used to grade the size of plaques as grade 1, one or more small plaques (<20 mm2); grade 2, moderate to large plaques; and grade 3, plaques giving flow disturbances. The plaque morphology in terms of echogenicity was graded as echolucent, 1; predominantly echolucent, 2; predominantly echogenic, 3; echogenic 4; or calcified, 5. The plaque surface was categorized as smooth, irregular, or ulcerated. The patients underwent carotid duplex ultrasound imaging at 6 weeks and at 6, 12, and 24 months after CEA. Mann-Whitney U test, χ2 test, and multivariate logistic regression were used for statistical evaluation.ResultsInternal carotid artery restenosis of ≥50% was detected in 33 patients (10.28%) in the operated region. Neither the size (grade 1, P = .793; grade 2, P = .540; grade 3, P = .395) nor the surface characteristics of the femoral plaques (smooth, P = .278; irregular, P = .281; ulcerated, P = .934) were significantly different between the patients with and without carotid restenosis. Echolucent-predominantly echolucent femoral lesions were an independent predictor of recurrent carotid stenosis (adjusted odds ratio, 5.63; 95% confidence interval, 2.14-10.89; P < .001).ConclusionUltrasound evaluation of femoral plaque morphology before CEA can be useful for identifying patients at higher risk for carotid restenosis
A highly sensitive mean-reverting process in finance and the Euler–Maruyama approximations

AbstractEmpirical studies show that the most successful continuous-time models of the short-term rate in capturing the dynamics are those that allow the volatility of interest changes to be highly sensitive to the level of the rate. However, from the mathematics, the high sensitivity to the level implies that the coefficients do not satisfy the linear growth condition, so we can not examine its properties by traditional techniques. This paper overcomes the mathematical difficulties due to the nonlinear growth and examines its analytical properties and the convergence of numerical solutions in probability. The convergence result can be used to justify the method within Monte Carlo simulations that compute the expected payoff of financial products. For illustration, we apply our results compute the value of a bond with interest rate given by the highly sensitive mean-reverting process as well as the value of a single barrier call option with the asset price governed by this process
CD45RO+ Memory T Lymphocytes — a Candidate Marker for TNM-Immunoscore in Squamous Non–Small Cell Lung Cancer

AbstractTumor-infiltrating lymphocytes (TILs) are vital in limiting cancer progression and may supplement the TNM classification. CD45RO+ memory TILs show major prognostic impact in various malignancies but have not been extensively explored in non–small cell lung cancer (NSCLC). In this study, we aimed to evaluate their potential in a NSCLC TNM-Immunoscore. Tissue microarrays were constructed from tumor tissue samples from two cohorts including in total 536 patients (University Hospital of North Norway, n = 285; Nordland Hospital, n = 251) with primary resected stage I to IIIA NSCLC. The density of CD45RO+ and CD8+ TILs in tumor epithelial and stromal compartments of the tumors was evaluated by immunohistochemistry. In univariate analyses, intraepithelial CD45RO+ TIL density (T-CD45RO) was a significant prognostic factor for disease-specific survival (P = .007), limited to the squamous cell carcinoma (SCC) histology subgroup (P < .001), where it was significant in both cohorts (University Hospital of North Norway, P = .003; Nordland Hospital, P = .022). Combining T-CD45RO and stromal CD8+ TIL density (S-CD8) increased the prognostic impact in SCC (P < .001) and showed a significant impact within all pathological stages (I, P = .025; II, P < .001; III, P = .001). In the multivariate analysis, T-CD45RO was an independent positive prognostic factor for SCC (hazard ratio 2.65, 95% confidence interval 1.64-4.28, P < .001), and in combination with S-CD8, the prognostic impact increased vastly (high + high versus low + low: hazard ratio 6.50, 95% confidence interval 3.54-11.91, P < .001). In conclusion, T-CD45RO was an independent prognostic factor for SCC NSCLC. When combined with S-CD8, the prognostic impact increased and was significant within each pathological stage. We propose CD45RO as a candidate marker for TNM-Immunoscore in SCC NSCLC
Evidence of exposure to Rickettsia felis in Australian patients

AbstractRickettsia felis is an emerging zoonosis, causing flea-borne spotted fever (FBSF). Serological diagnosis is typically confounded by cross-reactivity with typhus group rickettsiae and prior to the development of specific serological methods, cases of FBSF in Australia were misdiagnosed.Patient sera tested between August 2010 and December 2013 and known to be seropositive to R. typhi by immunofluorescence antibody testing (IFAT) were subsequently retested against R. felis using an R. felis-specific IFAT. Sera of 49 patients were of a sufficient quality to be included in re-analysis. A classification of FBSF and murine typhus (MT) was attributed to fourteen and seven patients respectively, based on a minimum four-fold higher antibody titre to R. felis than to R. typhi and vice versa. Twenty-eight patients were classified as indeterminate for either R. felis or R. typhi (antibody titres within two-fold of one another).Historically, it is likely that Australian patients clinically ill with FBSF were misdiagnosed. It is important that medical practitioners consider FBSF as part of their differential diagnoses, and obtain relevant history with regard to patient's exposure to domestic pets and their fleas. Australian microbiology diagnostic laboratories should include serological testing for R. felis as part of the diagnostic panel for febrile diseases. Veterinarians are encouraged to increase their awareness of this emerging zoonosis and advocate flea control in pets
An exactly solvable supersymmetric spin chain of BCN type

AbstractWe construct a new exactly solvable supersymmetric spin chain related to the BCN extended root system, which includes as a particular case the BCN version of the Polychronakos–Frahm spin chain. We also introduce a supersymmetric spin dynamical model of Calogero type which yields the new chain in the large coupling limit. This connection is exploited to derive two different closed-form expressions for the chain's partition function by means of Polychronakos's freezing trick. We establish a boson–fermion duality relation for the new chain's spectrum, which is in fact valid for a large class of (not necessarily integrable) spin chains of BCN type. The exact expressions for the partition function are also used to study the chain's spectrum as a whole, showing that the level density is normally distributed even for a moderately large number of particles. We also determine a simple analytic approximation to the distribution of normalized spacings between consecutive levels which fits the numerical data with remarkable accuracy. Our results provide further evidence that spin chains of Haldane–Shastry type are exceptional integrable models, in the sense that their spacings distribution is not Poissonian, as posited by the Berry–Tabor conjecture for “generic” quantum integrable systems
Analysing and modelling the performance of the HemeLB lattice-Boltzmann simulation environment

AbstractWe investigate the performance of the HemeLB lattice-Boltzmann simulator for cerebrovascular blood flow, aimed at providing timely and clinically relevant assistance to neurosurgeons. HemeLB is optimised for sparse geometries, supports interactive use, and scales well to 32,768 cores for problems with ∼81 million lattice sites. We obtain a maximum performance of 29.5 billion site updates per second, with only an 11% slowdown for highly sparse problems (5% fluid fraction). We present steering and visualisation performance measurements and provide a model which allows users to predict the performance, thereby determining how to run simulations with maximum accuracy within time constraints
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

SummaryObjectiveTo address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes.MethodsDescriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence’s of ROA before and after standardization in nine cohort studies. This procedure could only be performed in cohort studies and standardization of SOA definitions was not feasible at this moment.ResultsIn this consortium, all studies with SOA phenotypes (knee, hip and hand) used a different definition and/or assessment of OA status. For knee-, hip- and hand ROA five, four and seven different definitions were used, respectively. Different hip ROA definitions do lead to different association results. For example, we showed in the RSI that hip OA defined as “at least definite joint space narrowing (JSN) and one definite osteophyte” was not associated with gender (P =0.22), but defined as “at least one definite osteophyte” was significantly associated with gender (P=3×10−9). Therefore, a standardization process was undertaken for ROA definitions. Before standardization a wide range of ROA prevalence’s was observed in the nine cohorts studied. After standardization the range in prevalence of knee- and hip ROA was small.ConclusionPhenotype definitions influence the prevalence of OA and association with clinical variables. ROA phenotypes within the TREAT-OA consortium were standardized to reduce heterogeneity and improve power in future genetics studies
Measurement of D∗± meson production and F2c in deep-inelastic scattering at HERA

AbstractThe inclusive production of D∗±(2010) mesons in deep-inelastic scattering is studied with the H1 detector at HERA. In the kinematic region 1<Q2<100 GeV2 and 0.05<y<0.7 an e+p cross section for inclusive D∗± meson production of 8.50±0.42(stat.)+1.21−1.00(syst.) nb is measured in the visible range ptD∗>1.5 GeV and |ηD∗|<1.5. Single and double differential inclusive D∗± meson cross sections are compared to perturbative QCD calculations in two different evolution schemes. The charm contribution to the proton structure, F2c(x,Q2), is determined by extrapolating the visible charm cross section to the full phase space. This contribution is found to rise from about 10% at Q2=1.5 GeV2 to more than 25% at Q2=60 GeV2 corresponding to x values ranging from 5×10−5 to 3×10−3