pinecone/core-2020-05-10-deduplication huggingface dataset:
DADA: Data Assimilation for the Detection and Attribution of weather- and climate-related events

International audienceWe describe a new approach that allows for systematic causal attribution of weather and climate-related events, in near-real time. The method is designed so as to facilitate its implementation at meteorological centers by relying on data and methods that are routinely available when numerically forecasting the weather. We thus show that causal attribution can be obtained as a by-product of data assimilation procedures run on a daily basis to update numerical weather prediction (NWP) models with new atmospheric observations; hence, the proposed methodology can take advantage of the powerful computational and observational capacity of weather forecasting centers. We explain the theoretical rationale of this approach and sketch the most prominent features of a "data assimilation-based detection and attribution" (DADA) procedure. The proposal is illustrated in the context of the classical three-variable Lorenz model with additional forcing. The paper concludes by raising several theoretical and practical questions that need to be addressed to make the proposal operational within NWP centers
RORC1 Regulates Tumor-Promoting "Emergency" Granulo-Monocytopoiesis

Cancer-driven granulo-monocytopoiesis stimulates expansion of tumor promoting myeloid populations, mostly myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs). We identified subsets of MDSCs and TAMs based on the expression of retinoic-acid-related orphan receptor (RORC1/RORγ) in human and mouse tumor bearers. RORC1 orchestrates myelopoiesis by suppressing negative (Socs3 and Bcl3) and promoting positive (C/EBPβ) regulators of granulopoiesis, as well as the key transcriptional mediators of myeloid progenitor commitment and differentiation to the monocytic/macrophage lineage (IRF8 and PU.1). RORC1 supported tumor-promoting innate immunity by protecting MDSCs from apoptosis, mediating TAM differentiation and M2 polarization, and limiting tumor infiltration by mature neutrophils. Accordingly, ablation of RORC1 in the hematopoietic compartment prevented cancer-driven myelopoiesis, resulting in inhibition of tumor growth and metastasis. Strauss et al. show that RORC1 orchestrates myelopoiesis and supports tumor-promoting innate immunity. Importantly, ablation of RORC1 in the myeloid compartment inhibits tumor growth and metastasis, suggesting a cancer therapeutic approach
Search for a standard model-like Higgs boson in the mu+ mu- and e+ e- decay channels at the LHC

A search is presented for a standard model-like Higgs boson decaying to the μ+μ−μ+μ− or e+e−e+e− final states based on proton–proton collisions recorded by the CMS experiment at the CERN LHC. The data correspond to integrated luminosities of 5.0 fb−1 at a centre-of-mass energy of 7 TeV and 19.7 fb−1 at 8 TeV for the μ+μ−μ+μ− search, and of 19.7 fb−1 at 8 TeV for the e+e−e+e− search. Upper limits on the production cross section times branching fraction at the 95% confidence level are reported for Higgs boson masses in the range from 120 to 150 GeV. For a Higgs boson with a mass of 125 GeV decaying to μ+μ−μ+μ−, the observed (expected) upper limit on the production rate is found to be 7.4 (View the MathML source6.5−1.9+2.8) times the standard model value. This corresponds to an upper limit on the branching fraction of 0.0016. Similarly, for e+e−e+e−, an upper limit of 0.0019 is placed on the branching fraction, which is ≈3.7×105≈3.7×105 times the standard model value. These results, together with recent evidence of the 125 GeV boson coupling to τ-leptons with a larger branching fraction consistent with the standard model, confirm that the leptonic couplings of the new boson are not flavour-universal
Constraints on the Higgs boson width from off-shell production and decay to Z-boson pairs

Constraints are presented on the total width of the recently discovered Higgs boson, ΓHΓH, using its relative on-shell and off-shell production and decay rates to a pair of Z bosons, where one Z boson decays to an electron or muon pair, and the other to an electron, muon, or neutrino pair. The analysis is based on the data collected by the CMS experiment at the LHC in 2011 and 2012, corresponding to integrated luminosities of 5.1 fb−15.1 fb−1 at a center-of-mass energy View the MathML sources=7 TeV and 19.7 fb−119.7 fb−1 at View the MathML sources=8 TeV. A simultaneous maximum likelihood fit to the measured kinematic distributions near the resonance peak and above the Z-boson pair production threshold leads to an upper limit on the Higgs boson width of ΓH<22 MeVΓH<22 MeV at a 95% confidence level, which is 5.4 times the expected value in the standard model at the measured mass of mH=125.6 GeVmH=125.6 GeV
Competition on fast track: an analysis of the first competitive\ud
market for HSR services

This paper gives an overview of the dual effects of the opening, in Italy, of the new HSR line with a single operator (between 2005-2012) and the effects of a new operator entering the HSR market (2012-onward), on supply, demand and prices, thus inferring the effects of competition in this typically monopolistic market. The analyses are based on source data (laws and regulations, business plans, timetables, prices) as well as ad hoc extensive surveys, such as on-board counts on the HSR and intercity trains, retrospect surveys, and RP/SP interviews. In addition, an integrated modeling system has been developed to forecast the effects of competing titnetables/services/prices in terms of different HSR operators, competing modes (air/auto/railways), services (1st class/2nd class, etc.) and newly generated trips
Corticosteroid status influences the volume of the rat cingulate cortex: a magnetic resonance imaging study

Imbalances in the corticosteroid milieu result in reductions in hippocampal volume in humans and experimental rodents. The
functional correlates of these changes include deficits in cognitive performance and regulation of the hypothalamic–pituitary–adre-
nal axis. Since other limbic structures which are intricately connected with the hippocampal formation, also play an important role in behavioural and neuroendocrine functions, we here used magnetic resonance imaging (MRI) to analyse how two of these areas, the anterior cingulate and retrosplenial cortex, respond to chronic alterations of adrenocortical status: hypocortisolism (induced by adrenalectomy, ADX), normocortisolism (ADX with low-dose corticosterone replacement), and hypercortisolism (ADX with high-
dose dexamethasone supplementation). Hypercortisolism was associated with a significant reduction in the volume (absolute and normalized) of the left anterior cingulate gyrus as measured by MRI and confirmed using classical histological methods; a similar trend was observed in the right anterior cingulate region. In contrast, hypercortisolism did not influence the volume of the adjacent
retrosplenial cortex. The volumes of the anterior cingulate gyrus and retrosplenial cortex were unaffected by the absence of adre-nocortical hormones. These findings are the first to suggest that corticosteroid influences on the structure of the limbic system extend beyond the hippocampal formation, i.e., to fronto-limbic areas also
Searches for heavy long-lived charged particles with the ATLAS detector in proton--proton collisions at s√ = 8 TeV

Searches for heavy long-lived charged particles are performed using a data sample of 19.8 fb−1 from proton--proton collisions at a centre-of-mass energy of s√ = 8 TeV collected by the ATLAS detector at the Large Hadron Collider. No excess is observed above the estimated background and limits are placed on the mass of long-lived particles in various supersymmetric models. Long-lived tau sleptons in models with gauge-mediated symmetry breaking are excluded up to masses between 440 and 385 GeV for tan(beta) between 10 and 50, with a 290 GeV limit in the case where only direct tau slepton production is considered. In the context of simplified LeptoSUSY models, where sleptons are stable and have a mass of 300 GeV, squark and gluino masses are excluded up to a mass of 1500 and 1360 GeV, respectively. Directly produced charginos, in simplified models where they are nearly degenerate to the lightest neutralino, are excluded up to a mass of 620 GeV. R-hadrons, composites containing a gluino, bottom squark or top squark, are excluded up to a mass of 1270, 845 and 900 GeV, respectively, using the full detector; and up to a mass of 1260, 835 and 870 GeV using an approach disregarding information from the muon spectrometer.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT and NSRF, Greece; ISF, MINERVA, GIF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW and NCN, Poland; GRICES and FCT, Portugal; MNE/IFA, Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America
A globin domain in a neuronal transmembrane receptor of Caenorhabditis elegans and Ascaris suum: molecular modeling and functional properties

We report the structural and biochemical characterization of GLB-33, a putative neuropeptide receptor that is exclusively expressed in the nervous system of the nematode Caenorhabditis elegans. This unique chimeric protein is composed of a 7-transmembrane domain (7TM), GLB-33 7TM, typical of a G-protein-coupled receptor, and of a globin domain (GD), GLB-33 GD. Comprehensive sequence similarity searches in the genome of the parasitic nematode, Ascaris suum, revealed a chimeric protein that is similar to a Phe-Met-Arg-Phe-amide neuropeptide receptor. The three-dimensional structures of the separate domains of both species and of the full-length proteins were modeled. The 7TM domains of both proteins appeared very similar, but the globin domain of the A. suum receptor surprisingly seemed to lack several helices, suggesting a novel truncated globin fold. The globin domain of C. elegans GLB-33, however, was very similar to a genuine myoglobin-type molecule. Spectroscopic analysis of the recombinant GLB-33 GD showed that the heme is pentacoordinate when ferrous and in the hydroxide-ligated form when ferric, even at neutral pH. Flash-photolysis experiments showed overall fast biphasic CO rebinding kinetics. In its ferrous deoxy form, GLB-33 GD is capable of reversibly binding O-2 with a very high affinity and of reducing nitrite to nitric oxide faster than other globins. Collectively, these properties suggest that the globin domain of GLB-33 may serve as a highly sensitive oxygen sensor and/or as a nitrite reductase. Both properties are potentially able to modulate the neuropeptide sensitivity of the neuronal transmembrane receptor
Search for new phenomena in events with a photon and missing transverse momentum in pp collisions at s√=13 TeV with the ATLAS detector

Results of a search for new phenomena in events with an energetic photon and large missing transverse momentum with the ATLAS experiment at the Large Hadron Collider are reported. The data were collected in proton-proton collisions at a centre-of-mass energy of 13 TeV and correspond to an integrated luminosity of 3.2 fb−1. The observed data are in agreement with the Standard Model expectations. Exclusion limits are presented in models of new phenomena including pair production of dark matter candidates or large extra spatial dimensions. In a simplified model of dark matter and an axial-vector mediator, the search excludes mediator masses below 710 GeV for dark matter candidate masses below 150 GeV. In an effective theory of dark matter production, values of the suppression scale M∗ up to 570 GeV are excluded and the effect of truncation for various coupling values is reported. For the ADD large extra spatial dimension model the search places more stringent limits than earlier searches in the same event topology, excluding MD up to about 2.3 (2.8) TeV for two (six) additional spatial dimensions; the limits are reduced by 20-40% depending on the number of additional spatial dimensions when applying a truncation procedure
Search for anomalous tt̄ production in the highly-boosted all-hadronic final stat

Journal of High Energy Physics 2012.9 (2012): 029 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMA search is presented for a massive particle, generically referred to as a Z', decaying into a tt̄ pair. The search focuses on Z' resonances that are sufficiently massive to produce highly Lorentz-boosted top quarks, which yield collimated decay products that are partially or fully merged into single jets. The analysis uses new methods to analyze jet substructure, providing suppression of the non-top multijet backgrounds. The analysis is based on a data sample of proton-proton collisions at a center-of-mass energy of 7 TeV, corresponding to an integrated luminosity of 5 fb -1. Upper limits in the range of 1 pb are set on the product of the production cross section and branching fraction for a topcolor Z' modeled for several widths, as well as for a Randall-Sundrum Kaluza-Klein gluon. In addition, the result contrain any enhancement in tt̄ production beyond expectations of the standard mode for tt invariant mass larger than 1TeV/c
Measurement of the prompt J/ψ and ψ(2S) polarizations in pp collisions at √s=7 TeV

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMThe polarizations of prompt J/ψ and ψ(2S) mesons are measured in proton–proton collisions at √s =7 TeV, using a dimuon data sample collected by the CMS experiment at the LHC, corresponding to an integrated luminosity of 4.9 fb−1. The prompt J/ψ and ψ(2S) polarization parameters λϑ, λφ, and λϑφ, as well as the frame-invariant quantity λ, are measured from the dimuon decay angular distributions in three different polarization frames. The J/ψ results are obtained in the transverse momentum range 14<pT<70 GeV, in the rapidity intervals |y|<0.6 and 0.6<|y|<1.2. The corresponding ψ(2S) results cover 14<pT<50 GeV and include a third rapidity bin, 1.2<|y|<1.5. No evidence of large polarizations is seen in these kinematic regions, which extend much beyond those previously exploredIn addition, we gratefully acknowledge the computing centres and personnel of the Worldwide LHC Computing Grid for delivering so effectively the computing infrastructure essential to our analyses. Finally, we acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies: BMWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MEYS (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); MoER, SF0690030s09 and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Republic of Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); MSI (New Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MON, RosAtom, RAS and RFBR (Russia); MSTD (Serbia); SEIDI and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); ThEPCenter, IPST and NSTDA (Thailand); TUBITAK and TAEK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (USA). Individuals have received support from the Marie-Curie programme and the European Research Council and EPLANET (European Union); the Leventis Foundation; the A.P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans lʼIndustrie et dans lʼAgriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the Ministry of Education, Youth and Sports (MEYS) of Czech Republic; the Council of Science and Industrial Research, India; the Compagnia di San Paolo (Torino); the HOMING PLUS programme of Foundation for Polish Science, cofinanced by EU, Regional Development Fund; and the Thalis and Aristeia programmes cofinanced by EU-ESF and the Greek NSR
Search for a heavy Standard Model Higgs boson in the channel H→ZZ→ℓ+ℓ-qq̄ using the ATLAS detector

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMA search for a heavy Standard Model Higgs boson decaying via H → Z Z →ℓ+ℓ−qq, where ℓ= e,μ, is presented. The search is performed using a data set of pp collisions at √ s = 7 TeV, corresponding to an integrated luminosity of 1.04 fb−1 collected in 2011 by the ATLAS detector at the CERN LHC collider. No significant excess of events above the estimated background is found. Upper limits at 95% confidence level on the production cross section (relative to that expected from the Standard Model) of a Higgs boson with a mass in the range between 200 and 600 GeV are derived. Within this mass range, there is at present insufficient sensitivity to exclude a Standard Model Higgs boson. For a Higgs boson with a mass of 360 GeV, where the sensitivity is maximal, the observed and expected cross section upper limits are factors of 1.7 and 2.7, respectively, larger than the Standard Model predictionWe thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; ARTEMIS, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNAS, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT, Greece; ISF, MINERVA, GIF, DIP and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN and the ATLAS Tier- 1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NLT1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA) and in the Tier-2 facilities worldwid
The Aarhus statement : improving design and reporting of studies on early cancer diagnosis. \ud
\ud

Early diagnosis is a key factor in improving the outcomes of cancer patients. A greater understanding of the pre-diagnostic patient pathways is vital yet, at present, research in this field lacks consistent definitions and methods. As a consequence much early diagnosis research is difficult to interpret. A consensus group was formed with the aim of producing guidance and a checklist for early cancer-diagnosis researchers. A consensus conference approach combined with nominal group techniques was used. The work was supported by a systematic review of early diagnosis literature, focussing on existing instruments used to measure time points and intervals in early cancer-diagnosis research. A series of recommendations for definitions and methodological approaches is presented. This is complemented by a checklist that early diagnosis researchers can use when designing and conducting studies in this field. The Aarhus checklist is a resource for early cancer-diagnosis research that should promote greater precision and transparency in both definitions and methods. Further work will examine whether the checklist can be readily adopted by researchers, and feedback on the guidance will be used in future updates.\ud
\u
Newton method for symmetric quartic polynomial

We investigate the parameter plane of the Newton’s method applied to the family of quartic polynomials pa,b(z)=z4+az3+bz2+az+1,pa,b(z)=z4+az3+bz2+az+1, where a and b   are real parameters. We divide the parameter plane (a,b)∈R2(a,b)∈R2 into twelve open and connected regions where p, p′ and p′′ have simple roots. In each of these regions we focus on the study of the Newton’s operator acting on the Riemann sphere.The authors would like to thank N. Fagella and J. Canela for their useful comments during the preparation of this manuscript. The third author is partially supported by the Polish NCN grant decision DEC-2012/06/M/ST1/00168. The second and third authors are supported by the Spanish project MTM2014-52209-C2-2-P and the Catalan project CIRIT 2014-SGR555.The first and the last authors are supported by the Spanish project MTM2014-52016-C02-2-P and UJI project P1.1B20115-16
Muon-Electron Conversion in a Family Gauge Boson Model

We study the $\mu$-$e$ conversion in muonic atoms via an exchange of family
gauge boson (FGB) $A_{2}^{\ 1}$ in a $U(3)$ FGB model. Within the class of FGB
model, we consider three types of family-number assignments for quarks. We
evaluate the $\mu$-$e$ conversion rate for various target nuclei, and find that
next generation $\mu$-$e$ conversion search experiments can cover entire energy
scale of the model for all of types of the quark family-number assignments. We
show that the conversion rate in the model is so sensitive to up- and
down-quark mixing matrices, $U^{u}$ and $U^{d}$, where the CKM matrix is given
by $V_\text{CKM} = U^{u\dagger} U^d$. Precise measurements of conversion rates
for various target nuclei can identify not only the types of quark
family-number assignments, but also each quark mixing matrix individually.Comment: 14 pages, 3 figure