pinecone/core-2020-05-10-deduplication huggingface dataset:
Substrate-modulated thermal fluctuations affect long-range allosteric signaling in protein homodimers : exemplified in CAP.

The role of conformational dynamics in allosteric signaling of proteins is increasingly recognized as an important and subtle aspect of this ubiquitous phenomenon. Cooperative binding is commonly observed in proteins with twofold symmetry that bind two identical ligands. We construct a coarse-grained model of an allosteric coupled dimer and show how the signal can be propagated between the distant binding sites via change in slow global vibrational modes alone. We demonstrate that modulation on substrate binding of as few as 5–10 slow modes can give rise to cooperativity observed in biological systems and that the type of cooperativity is given by change of interaction between the two monomers upon ligand binding. To illustrate the application of the model, we apply it to a challenging test case: the catabolite activator protein (CAP). CAP displays negative cooperativity upon association with two identical ligands. The conformation of CAP is not affected by the binding, but its vibrational spectrum undergoes a strong modification. Intriguingly, the first binding enhances thermal fluctuations, yet the second quenches them. We show that this counterintuitive behavior is, in fact, necessary for an optimal anticooperative system, and captured within a well-defined region of the model's parameter space. From analyzing the experimental results, we conclude that fast local modes take an active part in the allostery of CAP, coupled to the more-global slow modes. By including them into the model, we elucidate the role of the modes on different timescales. We conclude that such dynamic control of allostery in homodimers may be a general phenomenon and that our model framework can be used for extended interpretation of thermodynamic parameters in other systems
Suicidal Behavior and Psychological Distress in University Students: A 12-Nation Study. Archives of Suicide Research

This study investigated the prevalence of suicidal behavior and psychological distress in university students across 12 nations. A total of 5572 university students from 12 countries were surveyed about suicide ideation, suicide attempts and psychological distress by means of a self-administered questionnaire. Almost 29% of the samples reported having contemplated suicide and 7% reported attempting suicide. Of the total sample, 51.1% scored above the General Health Questionnaire-12 ≥ 3 cut-off point, 41.6% above the GHQ-12 ≥ 4 cut-off point, and 33.8% scored above the GHQ-12 ≥ 5 cut-off point. While odds of suicide ideation were elevated in Austria and the UK, reduced ORs were detected for China, Italy, Saudi Arabia, Tunisia, and Turkey. Similarly, while odds of suicide attempt were high in Jordan, Palestine, Saudi Arabia, and to some extent in Turkey, reduced ORs were observed for Austria, China, Italy, Japan and the USA. Elevated ORs for psychological distress were seen in Japan, Jordan, Palestine, Saudi Arabia, Tunisia and Turkey but reduced ORs were noted in Austria, China, Iran, Italy and the USA. Psychological distress was strongly associated with reports of suicide ideation and attempts. Suicide ideation, suicide attempt and psychological distress are common in university students but their rates vary depending on the sociocultural context. Due attention should be devoted to the mental health needs of young adults enrolled in higher educational institutions and more cross-cultural research is warranted to better understand the etiology of the observed intersocietal variations in suicidal behavior and psychological distress
Measurement of the muon charge asymmetry in inclusive $pp \rightarrow W
  + X$ production at $\sqrt{s} = 7$ TeV at CMS and an improved determination of
  light parton distribution functions

Measurements of the muon charge asymmetry in inclusive $pp \rightarrow WX$
production at $\sqrt{s}=7$ TeV are presented. The data sample corresponds to an
integrated luminosity of 4.7 $\mathrm{fb^{-1}}$ recorded with the CMS detector
at the LHC. With a sample of more than twenty million $W \rightarrow \mu\nu$
events, the statistical precision is greatly improved in comparison to previous
measurements. These new results provide additional constraints on the parton
distribution functions of the proton in the range of the Bjorken scaling
variable $x$ from $10^{-3}$ to $10^{-1}$. These measurements are used together
with the cross sections for inclusive deep inelastic ep scattering at HERA in a
next-to-leading-order QCD analysis.Comment: 6 pages, 11 figures. Proceedings of the 37th International Conference
  on High Energy Physics, ICHEP 201
Corrigendum to "Flavour Covariant Transport Equations: an Application to
  Resonant Leptogenesis"

We amend the incorrect discussion in Nucl. Phys. B 886 (2014) 569 [1]
concerning the numerical examples considered there. In particular, we discuss
the viability of minimal radiative models of Resonant Leptogenesis and prove
that no asymmetry can be generated at $\mathcal{O}(h^4)$ in these scenarios. We
present a minimal modification of the model considered in [1], where
electroweak-scale right-handed Majorana neutrinos can easily accommodate both
successful leptogenesis and observable signatures at Lepton Number and Flavour
Violation experiments. The importance of the fully flavour-covariant rate
equations, as developed in [1], for describing accurately the generation of the
lepton asymmetry is reconfirmed.Comment: 10 pages, 4 figures; journal versio
On analytical study of holographic superconductors with Born-Infeld
  electrodynamics

Based on the Sturm-Liouville eigenvalue problem, Banerjee \emph{et al.}
proposed a perturbative approach to analytically investigate the properties of
the ($2+1$)-dimensional superconductor with Born-Infeld electrodynamics [Phys.
Rev. D {\bf 87}, 104001 (2013)]. By introducing an iterative procedure, we will
further improve the analytical results and the consistency with the numerical
findings, and can easily extend the analytical study to the higher-dimensional
superconductor with Born-Infeld electrodynamics. We observe that the higher
Born-Infeld corrections make it harder for the condensation to form but do not
affect the critical phenomena of the system. Our analytical results can be used
to back up the numerical computations for the holographic superconductors with
various condensates in Born-Infeld electrodynamics.Comment: 13 pages, 4 tables, accepted for publication in Phys. Lett.
Crustal growth during island arc accretion and transcurrent deformation, Natal Metamorphic Province, South Africa: New isotopic constraints

The Natal Metamorphic Province consists of, from north to south, the Tugela, Mzumbe, and Margate Terranes. These were accreted to the southeastern margin of the Kaapvaal Craton in the late Mesoproterozoic, and followed by intrusion of a large suite of A-type granitoid bodies. New U–Pb data from zircon, titanite, and monazite further constrains the temporal framework of these geological events.\ud
\ud
The Tugela and Mzumbe Terranes record protracted magmatism in an island arc complex from ∼1200 Ma to 1160 Ma, followed by the accretion of these terranes onto the southern margin of the Kaapvaal Craton at ∼1150 Ma. Arc magmatism in the Margate Terrane continued until ∼1120 Ma and was followed by extension and bimodal volcanism immediately prior to accretion to the Kaapvaal/Mzumbe continental margin at ∼1090 Ma. This accretion was accompanied by high-pressure and high-temperature metamorphism, juxtaposition of the Mzumbe and Margate Terranes along the Melville Thrust, and the formation of a number of syntectonic intrusive units derived from melting of the pre-existing arc crust. After accretion, extensional collapse is evidenced by the intrusion of mafic/ultramafic and alkaline intermediate magmatic suites at ∼1085 Ma, resulting from mafic underplating and/or lower crustal delamination. Nd and Hf isotopic data imply the magmatic rocks of the Natal Metamorphic Province were derived from relatively juvenile continental crust, initially generated by island arc magmatism and subsequently reworked during the accretion event(s). The combined Kaapvaal-NMP region (the southern margin of the enlarged Kalahari Craton) then experienced extensive sinistral transcurrent deformation centred along a series of discrete steep shear zones that are found from the Kaapvaal cratonic margin to the southernmost portion of the Natal Metamorphic Province. This deformation is accompanied by low-pressure, (ultra)high-temperature metamorphism, isobaric cooling, and intrusion of the voluminous A-type Oribi Gorge Suite porphyritic granites and charnockites throughout the Mzumbe and Margate Terranes
Adaptive mutation with fitness and allele distribution correlation for genetic algorithms

Copyright @ 2006 ACMIn this paper, a new gene based adaptive mutation scheme is proposed for genetic algorithms (GAs), where the information on gene based fitness statistics and on gene based allele distribution statistics are correlated to explicitly adapt the mutation probability for each gene locus over time. A convergence control mechanism is combined with the proposed mutation scheme to maintain sufficient diversity in the population. Experiments are carried out to compare the proposed mutation scheme to traditional mutation and two advanced adaptive mutation schemes on a set of optimization problems. The experimental results show that the proposed mutation scheme e ciently improves GA's performance
Search for a very light NMSSM Higgs boson produced in decays of the 125 GeV scalar boson and decaying into tau leptons in pp collisions at sqrt(s) = 8 TeV

A search for a very light Higgs boson decaying into a pair of tau leptons is presented within the framework of the next-to-minimal supersymmetric standard model. This search is based on a data set corresponding to an integrated luminosity of 19.7 inverse femtobarns of proton-proton collisions collected by the CMS experiment at a centre-of-mass energy of 8 TeV. The signal is defined by the production of either of the two lightest scalars, h[1] or h[2], via gluon-gluon fusion and subsequent decay into a pair of the lightest Higgs bosons, a[1] or h[1]. The h[1] or h[2] boson is identified with the observed state at a mass of 125 GeV. The analysis searches for decays of the a[1] (h[1]) states into pairs of tau leptons and covers a mass range for the a[1] (h[1]) boson of 4 to 8 GeV. The search reveals no significant excess in data above standard model background expectations, and an upper limit is set on the signal production cross section times branching fraction as a function of the a[1] (h[1]) boson mass. The 95% confidence level limit ranges from 4.5 pb at m(a[1]) (m(h[1])) = 8 GeV to 10.3 pb at m(a[1]) (m(h[1])) = 5 GeV
Crop manuring and intensive land management by Europe’s first farmers

The spread of farming from western Asia to Europe had profound long-term social and ecological impacts, but identification of the specific nature of Neolithic land management practices and the dietary contribution of early crops has been problematic. Here, we present previously undescribed stable isotope determinations of charred cereals and pulses from 13 Neolithic sites across Europe
(dating ca. 5900–2400 cal B.C.), which show that early farmers used livestock manure and water management to enhance crop yields.
Intensive manuring inextricably linked plant cultivation and animal herding and contributed to the remarkable resilience of these combined practices across diverse climatic zones. Critically, our findings suggest that commonly applied paleodietary interpretations
of human and herbivore δ15N values have systematically
underestimated the contribution of crop-derived protein to early farmer diets.status: publishe
Electric dipole induced by gravity in fat branes

In the fat brane model, also known as the split fermion model, it is assumed that leptons and baryons live in different hypersurfaces of a thick brane in order to explain the proton stability without invoking any symmetry. It turns out that, in the presence of a gravity source M , particles will see different four-dimensional (4D) geometries and hence, from the point of view of 4D-observers, the equivalence principle will be violated. As a consequence, we show that a hydrogen atom in the gravitational field of M will acquire a radial electric dipole. This effect is regulated by the Hamiltonian <math altimg="si1.gif" xmlns="http://www.w3.org/1998/Math/MathML"><msub><mrow><mi>H</mi></mrow><mrow><mi>d</mi></mrow></msub><mo>=</mo><mo>−</mo><mi>μ</mi><mi mathvariant="bold">A</mi><mo>⋅</mo><mrow><mi>δr</mi></mrow></math> , which is the gravitational analog of the Stark Hamiltonian, where the electric field is replaced by the tidal acceleration A due to the split of fermions in the brane and the atomic reduced mass μ substitutes the electric charge
Experimental constraints on the ω –nucleus real potential

In a search for ω mesic states, the production of ω -mesons in coincidence with forward going protons has been studied in photon induced reactions on 12 C for incident photon energies of 1250–3100 MeV. The π0γ pairs from decays of bound or quasi-free ω -mesons have been measured with the CBELSA/TAPS detector system in coincidence with protons registered in the MiniTAPS forward array. Structures in the total energy distribution of the π0γ pairs, which would indicate the population and decay of bound ω 11 B states, are not observed. The π0γ cross section of 0.3 nb MeV −1  sr −1 observed in the bound state energy regime between −100 and 0 MeV may be accounted for by yield leaking into the bound state regime because of the large in-medium width of the ω -meson. A comparison of the measured total energy distribution with calculations suggests the real part V0 of the ω 11 B potential to be small and only weakly attractive with V0(ρ=ρ0)=−15±35(stat)±20(syst) MeV in contrast to some theoretical predictions of attractive potentials with a depth of 100–150 MeV
Building a Stückelberg portal

We construct explicit string theory models realizing the recently proposed “Stückelberg Portal” scenario, a framework for building Z ′ mediation models without the need to introduce unwanted exotic matter charged under the Standard Model. This scenario can be viewed purely field-theoretically, although it is particularly well motivated from string theory. By analyzing carefully the Stückelberg couplings between the Abelian gauge bosons and the RR axions, we construct the first global intersecting brane models which extend the Standard Model with a genuine hidden sector, to which it is nonetheless connected via U(1) mass mixings. Utilizing the explicit models we construct, we discuss some broad phenomenological properties and experimental implications of this scenario such as Z − Z ′ mixings, dark matter stability and relic density, and supersymmetry mediation. With an appropriate confining hidden sector, our setup also provides a minimal realization of the hidden valley scenario. We further explore the possibility of obtaining small Z ′ masses from a large ensemble of U(1) bosons. Related to the Stückelberg portal are two mechanisms that connect the visible and the hidden sectors, namely mediation by non-perturbative operators and the hidden photon scenario, on which we briefly comment
Search for a light charged Higgs boson in top quark decays in pp collisions at √s=7 TeV

Open Access. This article is distributed under the terms of the Creative Commons Attribution License.-- Chatrchyan, S. et al.Results are presented on a search for a light charged Higgs boson that can be produced in the decay of the top quark to charged H and b quark and which, in turn, decays into tau and tau neutrino. The analysed data correspond to an integrated luminosity of about 2 inverse femtobarns recorded in proton-proton collisions at √s=7 TeV by the CMS experiment at the LHC. The search is sensitive to the decays of the top quark pairs t anti-t to charged Higgs W b anti-b and t anti-t to charged Higgs b anti-b. Various final states have been studied separately, all requiring presence of a tau lepton from charged Higgs decays, missing transverse energy, and multiple jets. Upper limits on the branching fraction B(t to charged Higgs b) in the range of 2-3% are established for charged Higgs boson masses between 80 and 160 GeV, under the assumption that B(charged Higgs to tau anti-tau) = 1.Acknowledge support from: FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); MoER, SF0690030s09 and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Republic of Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); MSI (New Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MON, RosAtom, RAS and RFBR (Russia); MSTD (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA). Individuals have received support from the Marie-Curie programme and the European Research Council (European Union); the Leventis Foundation; the A.P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the Council of Science and Industrial Research, India; and the HOMING PLUS programme of Foundation for Polish Science, cofinanced from European Union, Regional Development Fund.Peer reviewe
Turning the Analytic Gaze on “Us”:The Role of Authorities in the Alienation of Minorities

What leads to the alienation and political (dis)engagement of minority groups is a critical question for political psychologists. Recently, research has focused attention on one particular minority group – Muslims in the West – and on what promotes “anti-Western” attitudes and behavior. Typically, the research focus is on factors internal to the individuals or the minority communities concerned. However, we argue this overlooks the ways in which the perspective and practices of the majority group affect minority group members’ understandings of who they are and how they stand in relation to the majority. In this paper we examine the social-psychological processes through which authorities’ surveillance and intervention affects minority group members’ sense of themselves, their relationship to authorities and the wider community. In doing so, we discuss a number of hitherto neglected psychological processes that may contribute to alienation-namely, processes of misrecognition, disrespect, and humiliation. We draw on research conducted with British Muslims to illustrate our argument for widening our analytic focus to give a more dynamic account of alienation and (dis)engagement
Mortality after surgery in Europe: a 7 day cohort study.

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe.\ud
We did this 7 day cohort study between April 4 and April 11, 2011. We collected data describing consecutive patients aged 16 years and older undergoing inpatient non-cardiac surgery in 498 hospitals across 28 European nations. Patients were followed up for a maximum of 60 days. The primary endpoint was in-hospital mortality. Secondary outcome measures were duration of hospital stay and admission to critical care. We used χ(2) and Fisher's exact tests to compare categorical variables and the t test or the Mann-Whitney U test to compare continuous variables. Significance was set at p<0·05. We constructed multilevel logistic regression models to adjust for the differences in mortality rates between countries.\ud
We included 46,539 patients, of whom 1855 (4%) died before hospital discharge. 3599 (8%) patients were admitted to critical care after surgery with a median length of stay of 1·2 days (IQR 0·9-3·6). 1358 (73%) patients who died were not admitted to critical care at any stage after surgery. Crude mortality rates varied widely between countries (from 1·2% [95% CI 0·0-3·0] for Iceland to 21·5% [16·9-26·2] for Latvia). After adjustment for confounding variables, important differences remained between countries when compared with the UK, the country with the largest dataset (OR range from 0·44 [95% CI 0·19-1·05; p=0·06] for Finland to 6·92 [2·37-20·27; p=0·0004] for Poland).\ud
The mortality rate for patients undergoing inpatient non-cardiac surgery was higher than anticipated. Variations in mortality between countries suggest the need for national and international strategies to improve care for this group of patients
Search for heavy lepton resonances decaying to a Z boson and a lepton in pp collisions at roots=8 TeV with the ATLAS detector

A search for heavy leptons decaying to a Z boson and an electron or a muon is presented. The search is based on pp collision data taken at root s = 8TeV by the ATLAS experiment at the CERN Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb(-1). Three high-transverse-momentum electrons or muons are selected, with two of them required to be consistent with originating from a Z boson decay. No significant excess above Standard Model background predictions is observed, and 95% confidence level limits on the production cross section of high-mass trilepton resonances are derived. The results are interpreted in the context of vector-like lepton and type-III seesaw models. For the vector-like lepton model, most heavy lepton mass values in the range 114-176 GeV are excluded. For the type-III seesaw model, most mass values in the range 100-468 GeV are excluded.<p>ATLAS Collaboration, for complete list of authors see http://dx.doi.org/10.1007/JHEP09(2015)108</p><p>Funding: We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT and NSRF, Greece; RGC, Hong Kong SAR, China; ISF, MINERVA, GIF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW and NCN, Poland; GRICES and FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America.</p