pinecone/core-2020-05-10-deduplication huggingface dataset:
Uncovering key patterns in self-harm in adolescents: Sequence analysis using the Card Sort Task for Self-harm (CaTS)

AbstractBackgroundSelf-harm is a significant clinical issue in adolescence. There is little research on the interplay of key factors in the months, weeks, days and hours leading to self-harm. We developed the Card Sort Task for Self-harm (CaTS) to investigate the pattern of thoughts, feelings, events and behaviours leading to self-harm.MethodsForty-five young people (aged 13–21 years) with recent repeated self-harm completed the CaTS to describe their first ever/most recent self-harm episode. Lag sequential analysis determined significant transitions in factors leading to self-harm (presented in state transition diagrams).ResultsA significant sequential structure to the card sequences produced was observed demonstrating similarities and important differences in antecedents to first and most recent self-harm. Life-events were distal in the self-harm pathway and more heterogeneous. Of significant clinical concern was that the wish to die and hopelessness emerged as important antecedents in the most recent episode. First ever self-harm was associated with feeling better afterward, but this disappeared for the most recent episode.LimitationsLarger sample sizes are necessary to examine longer chains of sequences and differences in genders, age and type of self-harm. The sample was self-selected with 53% having experience of living in care.ConclusionsThe CaTs offers a systematic approach to understanding the dynamic interplay of factors that lead to self-harm in young people. It offers a method to target key points for intervention in the self-harm pathway. Crucially the factors most proximal to self-harm (negative emotions, impulsivity and access to means) are modifiable with existing clinical interventions
Incoherent majorities: The McGarvey problem in judgement aggregation

AbstractJudgement aggregation is a model of social choice where the space of social alternatives is the set of consistent truth-valuations (‘judgements’) on a family of logically interconnected propositions. It is well known that propositionwise majority voting can yield logically inconsistent judgements. We show that, for a variety of spaces, propositionwise majority voting can yield any possible judgement. By considering the geometry of sub-polytopes of the Hamming cube, we also estimate the number of voters required to achieve all possible judgements. These results generalize the classic results of McGarvey (1953) [13] and Stearns (1959) [22]
Transverse activity of kaons and deconfinement phase transition in nucleus–nucleus collisions

AbstractWe found that the experimental results on transverse mass spectrum of kaons produced in central Pb+Pb (Au+Au) collisions show an anomalous dependence on the colliding energy. The inverse slope of the spectrum increases with the energy in the low (AGS) and high (RHIC) energy domains, whereas it remains constant in the intermediate (SPS) energy range. We argue that this anomaly is probably caused by the modification of the equation of state in the transition region between confined and deconfined matter. This observation may be considered as a new signal, in addition to the previously reported anomalies in the pion and strangeness production, of the onset of deconfinement located in the low SPS energy domain
Experimental constraints on the ω–nucleus real potential

AbstractIn a search for ω mesic states, the production of ω-mesons in coincidence with forward going protons has been studied in photon induced reactions on 12C for incident photon energies of 1250–3100 MeV. The π0γ pairs from decays of bound or quasi-free ω-mesons have been measured with the CBELSA/TAPS detector system in coincidence with protons registered in the MiniTAPS forward array. Structures in the total energy distribution of the π0γ pairs, which would indicate the population and decay of bound ω 11B states, are not observed. The π0γ cross section of 0.3 nb MeV−1 sr−1 observed in the bound state energy regime between −100 and 0 MeV may be accounted for by yield leaking into the bound state regime because of the large in-medium width of the ω-meson. A comparison of the measured total energy distribution with calculations suggests the real part V0 of the ω 11B potential to be small and only weakly attractive with V0(ρ=ρ0)=−15±35(stat)±20(syst) MeV in contrast to some theoretical predictions of attractive potentials with a depth of 100–150 MeV
Preparation and sintering behaviour of La5.4WO12−δ asymmetric membranes with optimised microstructure for hydrogen separation

AbstractLa5.4WO12−δ (LaWO) is a promising membrane candidate for a variety of H2-related applications due to its appreciable levels of mixed proton–electron conduction and its stability in moist reducing atmospheres at elevated temperatures. Governed by Wagner theory, the H2 permeation performance of a membrane can be enhanced by reducing its thickness. Therefore, the present work deals with preparing LaWO supported membranes with reduced thickness and optimised microstructure. Combining a dense membrane with a porous supporting layer is associated with mismatched sintering rates, which ultimately lead to bending effects. Therefore, the sintering behaviour of both the dense membrane and the porous substrate must be carefully adjusted to each other. For this purpose, single and co-fired membrane and substrate layers were produced by tape casting. Sintering experiments were carried out with an optical dilatometer. The shrinkage and microstructural evolution of the layers were evaluated in terms of the anisotropic shrinkage forces and the membrane rigidness counteracting the substrate shrinkage. The results were used to develop asymmetric LaWO membranes with optimal microstructure. High membrane density was combined with a substrate porosity of ~30% and minimised bending (40µm). The LaWO membrane–substrate assembly displayed a He leakage of 10−5hPadm³cm−2s−1, which is a value that satisfies further practical demands
The reaction pd→(pp)n at high momentum transfer and short-range NN properties

AbstractA recent cross section measurement of the deuteron breakup reaction pd→(pp)(0°)+n(180°), in the GeV region in a kinematics similar to backward pd elastic scattering, strongly contradicts predictions of a pd→dp model based on the one-nucleon exchange, single pN scattering and Δ excitation mechanisms, and on the wave functions of the Reid soft core and Paris NN potentials. We show within the same model that for the CD Bonn NN potential there is qualitative agreement with the data. It is attributed to a reduction of the one-nucleon exchange at energies above 1 GeV and an increase of the Δ(1232)-isobar contribution, both related to the short-range properties of the wave functions generated by this potential
Influence of the Axial Ligand on the Cationic Properties of the Chlorophyll Pair in Photosystem II from Thermosynechococcus vulcanus

AbstractInfluence of the axial ligand of PD1 chlorophyll (D1-His-198) on the Em of monomer chlorophylls PD1 and PD2, and the PD1•+/PD2•+ charge ratio was investigated by theoretical calculations using the PSII crystal structure of Thermosynechococcus vulcanus analyzed at 1.9-Å resolution. It was found that the Em(PD1)/Em(PD2) values and PD1•+/PD2•+ ratio remained unchanged upon D1-H198Q mutation. However, Em(PD1) was increased in the D1-H198A mutant, resulting in a more even distribution of the positive charge over PD1/PD2. Introduction of a water molecule as an axial ligand resulted in equal Em values and PD1•+/PD2•+ ratios between the mutant and wild-type, thus confirming the presence of the water ligand in the mutant
The nucleon's octet axial-charge gA(8) with chiral corrections

AbstractThe value of the nucleon's flavour-singlet axial-charge extracted from polarised deep inelastic scattering is sensitive to the value of the octet axial-charge gA(8) which is usually taken from an analysis of hyperon β-decays within the framework of SU(3) symmetry, namely 0.58±0.03. Using the Cloudy Bag model we find that the value of gA(8) is reduced by as much as 20% below the usual phenomenological value. This increases the value of the flavour-singlet axial-charge (gA(0)|inv) derived from deep inelastic data and significantly reduces the difference between it and gA(8)
Oxo-phytodienoic acid (OPDA) is formed on fatty acids esterified to galactolipids after tissue disruption in Arabidopsis thaliana

AbstractBiotic and abiotic stress induces the formation of galactolipids esterified with the phytohormones 12-oxo-phytodienoic acid (OPDA) and dinor-oxo-phytodienoic acid (dnOPDA) in Arabidopsis thaliana. The biosynthetic pathways of free (dn)OPDA is well described, but it is unclear how they are incorporated into galactolipids. We herein show that (dn)OPDA containing lipids are formed rapidly after disruption of cellular integrity in leaf tissue. Five minutes after freeze-thawing, 60–70% of the trienoic acids esterified to chloroplast galactolipids are converted to (dn)OPDA. Stable isotope labeling with 18O-water provides strong evidence for that the fatty acids remain attached to galactolipids during the enzymatic conversion to (dn)OPDA
Hearing voices in the resting brain: A review of intrinsic functional connectivity research on auditory verbal hallucinations

AbstractResting state networks (RSNs) are thought to reflect the intrinsic functional connectivity of brain regions. Alterations to RSNs have been proposed to underpin various kinds of psychopathology, including the occurrence of auditory verbal hallucinations (AVH). This review outlines the main hypotheses linking AVH and the resting state, and assesses the evidence for alterations to intrinsic connectivity provided by studies of resting fMRI in AVH. The influence of hallucinations during data acquisition, medication confounds, and movement are also considered. Despite a large variety of analytic methods and designs being deployed, it is possible to conclude that resting connectivity in the left temporal lobe in general and left superior temporal gyrus in particular are disrupted in AVH. There is also preliminary evidence of atypical connectivity in the default mode network and its interaction with other RSNs. Recommendations for future research include the adoption of a common analysis protocol to allow for more overlapping datasets and replication of intrinsic functional connectivity alterations
Hyperfine mixing in electromagnetic decay of doubly heavy bc baryons

AbstractWe investigate the role of hyperfine mixing in the electromagnetic decay of ground state doubly heavy bc baryons. As in the case of a previous calculation on b→c semileptonic decays of doubly heavy baryons, we find large corrections to the electromagnetic decay widths due to this mixing. Contrary to the weak case just mentioned, we find here that one cannot use electromagnetic width relations obtained in the infinite heavy quark mass limit to experimentally extract information on the admixtures in a model independent way
Trends in chemotherapy for elderly patients with advanced non-small-cell lung cancer

SummaryBackgroundIn approximately the year 2000, the results of a number of important studies of non-small-cell lung cancer (NSCLC) were published.MethodsBetween July 1992 and December 2003, 223 patients with NSCLC aged ≥70 years received chemotherapy alone as their initial treatment at the National Cancer Center Hospital East. These patients were divided into 2 groups: those that began treatment between 1992 and 1999 (group A) and between 2000 and 2003 (group B). The details of chemotherapy regimens and outcomes were compared.ResultsIn group A, 83% of patients received platinum-based chemotherapy, two-thirds of these regimens comprised platinum plus second-generation combination chemotherapy. In contrast, although 55% of patients received platinum-based chemotherapy in group B, 41% of patients received non-platinum-based chemotherapy. Among patients in group B, performance status was significantly associated with the selection of platinum-based or non-platinum-based chemotherapy; age was marginally associated with this selection. Median survival time (MST), 1-year survival rate, and 2-year survival rate were 6.7 months, 14%, and 7%, respectively, in group A, and 8.1 months, 35%, and 20% in group B (p=0.0109). Multivariate analysis revealed that clinical stage and administration of salvage chemotherapy were independent prognostic factors.ConclusionsIn and after the year 2000, chemotherapy regimens changed greatly and survival of elderly patients significantly improved in our institute, and this improvement appears to be attributable mostly to the effect of salvage chemotherapy. These results suggest that even elderly patients should be offered salvage chemotherapy regardless of age, if possible
Disruption of TNF-α/TNFR1 Function in Resident Skin Cells Impairs Host Immune Response against Cutaneous Vaccinia Virus Infection

One strategy adopted by vaccinia virus (VV) to evade the host immune system is to encode homologs of TNF receptors (TNFRs) that block TNF-α function. The response to VV skin infection under conditions of TNF-α deficiency, however, has not been reported. We found that TNFR1-/- mice developed larger primary lesions, numerous satellite lesions, and higher skin virus levels after VV scarification. Following their recovery, VV-scarified TNFR1-/- mice were fully protected against challenge with a lethal intranasal dose of VV, suggesting these mice had developed an effective memory immune response. A functional systemic immune response was further demonstrated by enhanced production of VV-specific IFN-γ and VV-specific CD8+ T cells in spleens and draining lymph nodes. Interestingly, bone marrow (BM)–reconstitution studies using wild-type (WT) BM in TNFR1-/- host mice, but not TNFR1-/- BM in WT host mice, reproduced the original results seen in TNFR1-/- mice, indicating that TNFR1 deficiency in resident skin cells, rather than hematopoietic cells, accounts for the impaired cutaneous immune response. Our data suggest that lack of TNFR1 leads to a skin-specific immune deficiency, and that resident skin cells have a crucial role in mediating an optimal immune defense to VV cutaneous infection via TNF-α/TNFR1 signaling
CityPro; An Integrated City-protection Collaborative Platform

AbstractIt's a big challenge to deal with security in a city. Technology advancements are influencing our life, cities are evolving, and modern cities are referring more and more to digital technologies. Currently, a huge amount of standalone independent-systems operate in the city, their goal is to satisfy some business activities, e.g. banking, customs, hospitals, etc. Data collected by these systems represents, if integrated, a key element in any decision making process. This paper presents a, working, smart collaborative platform to integrate multiple systems to serve the surveillance activities in a city or country. It consists of a collaborative surveillance system, called CityPro. The architecture that we propose is a future vision to protect people and monitor public infrastructures, such as bridges, roads, buildings, etc.; it is designed to deal with and/or prevent abnormal activities like terrorist attacks. CityPro is expected to operate in live-mode by using (intended to use) city adapted IT-infrastructures. At the end of this paper, a typical case study is given, and challenges and future works are also discussed
Down-hole heavy crude oil upgrading by CAPRI: Effect of hydrogen and methane gases upon upgrading and coke formation

AbstractHeavy oil and bitumen resources will need to be exploited to supplement depleting conventional oils worldwide as they gradually approach their peak production in the forthcoming decades. However, the physico-chemical characteristics of heavy oil and bitumen include high density, low distillates fraction, high viscosity, and high hetero-atom content which make extraction difficult and relatively expensive. The Toe-to-Heel Air Injection (THAI) and ‘add-on’ Catalytic upgrading process in situ (CAPRI) were specifically developed for the recovery and upgrading of heavy oil and bitumen. In this study, the effects of reaction gas media used in THAI–CAPRI were investigated, in particular the effects of using hydrogen, methane, nitrogen, and a blended gas mixture to simulate THAI combustion gases with Co–Mo/γ-Al2O3 catalyst at a reaction temperature of 425°C, pressure 10bar, and gas-to-oil ratio 50mLmL−1. Ex situ regeneration of the spent catalyst by thermal oxidation of the asphaltenes and coke deposits was also investigated. It was found that the average changes in API gravity of the produced oil were 4° using hydrogen, 3° with methane, 2.9° with THAI gas, and 2.7° with nitrogen above the value of 14° API gravity for the feed oil. The viscosity reduction and conversion of hydrocarbons with boiling point 343°C+ into lower boiling distillable fractions followed the same trend as the API gravity. The percentage loss in specific surface areas as a result of coke deposition in the different reaction gases were as follows: 57.2% for hydrogen, 68% for methane, and 96% for nitrogen relative to the surface area of the fresh catalyst of 214.4m2g−1. It was found that the spent catalyst contained 6 and 3wt.% less coke after six hours operation when using hydrogen and methane reaction gases respectively compared to 23.5wt.% coke content in a nitrogen atmosphere. Also, 48.5% of the catalyst specific surface area was recovered after oxidative regeneration
Easy mammalian expression and crystallography of maltose-binding protein-fused human proteins

AbstractWe present a strategy to obtain milligrams of highly post-translationally modified eukaryotic proteins, transiently expressed in mammalian cells as rigid or cleavable fusions with a mammalianized version of bacterial maltose-binding protein (mMBP). This variant was engineered to combine mutations that enhance MBP solubility and affinity purification, as well as provide crystal-packing interactions for increased crystallizability. Using this cell type-independent approach, we could increase the expression of secreted and intracellular human proteins up to 200-fold. By molecular replacement with MBP, we readily determined five novel high-resolution structures of rigid fusions of targets that otherwise defied crystallization
Realism, skill, and incentives: Current and future trends in investment management and investment performance

AbstractWe review the recent trends in investment management and performance research and highlight the fields expected to develop further in the future. The trend to adapt the classic CAPM and factor models seems likely to continue, with the drive for realistic factors, which best proxy the drivers of investment performance, playing a key role. The search for skill, based on enhanced benchmarks, is also a developing area, with new concepts of identification and verification at the fore. The availability of more qualitative data has allowed corporate finance themes such as agency conflict and incentives to be explored. These are some of the areas where we have seen major developments in recent years and where we expect to see continuing development
Preoperative predictive factors of aneurysmal regression using the reporting standards for endovascular aortic aneurysm repair

BackgroundAneurysmal regression is a reliable marker for long-lasting success after endovascular aneurysm repair (EVAR). The aim of this study was to identify the preoperative factors that can predictably lead to aneurysmal sac regression after EVAR, according to the reporting standards of the Society for Vascular Surgery and the International Society of Cardiovascular Surgery (SVS/ISCVS).MethodsFrom 199 patients treated by EVAR between 2000 and 2009, 164 completed computed tomography angiographies and duplex scan follow-up images were available. All computed tomography angiographies for enrolled patients in this retrospective study were analyzed with Endosize software (Therenva, Rennes, France) to provide spatially correct 3-dimensional data in accordance with SVS/ISCVS recommendations. Anatomic parameters were graded according to the relevant severity grades. A severity score was calculated at the aortic neck, the abdominal aortic aneurysm, and the iliac arteries. Clinical and demographic factors were studied. Patients with aneurysmal regression >5 mm were assigned to group A (mean age, 71.4 ± 8.9 years) and the others to group B (76.3 ± 8.3 years).ResultsAneurysmal regression occurred in 66 patients (40.2%; group A). Univariate analyses showed smaller severity scores at the aortic neck (P = .02) and the iliac arteries (P = .002) in group A and calcifications and thrombus were less significant at the aortic neck (P = .003 and P = .02) and at the iliac arteries (P = .001 and P = .02), and inferior mesenteric artery patency was less frequent (68.2% vs 82.7%, P = .04). Two multivariate analyses were done: one considered the scores and the other the variables included in the scores. In the first, the patients of group A were younger (P = .002) and aortic neck calcifications were less significant (P = .007). In the second, group A patients were younger (P < .001) and the aortic neck scores were smaller (P = .04). There was no difference between the two groups in the type of implanted endoprosthesis or in the follow-up (group A: 46.4 ± 24 months; group B: 47.2 ± 22 months; P = .35).ConclusionsIn this study, the young age of the patients and their aortic neck quality, in particular the absence of neck calcification, appear to have been the main factors affecting aneurysm shrinkage, such that they represent a target population for the improvement of EVAR results
A triadic framework for collaborative consumption (CC): Motives, activities\ud
and resources & capabilities of actors

Collaborative consumption (CC) is an increasingly prevalent form of exchange. CC occurs within a triangle of\ud
actors: a platform provider (e.g., Uber), a peer service provider (e.g., an Uber driver) and a customer. The\ud
platform provider's main role is matchmaking, so that a customer can access assets of a peer service provider.\ud
This paper has three objectives. First, this article identifies three criteria to delineate CC from related constructs\ud
such as access-based consumption, sharing or renting. Second, it introduces a literature-based framework\ud
explicating the roles of the actors in the CC triangle along three dimensions: motives, activities and resources and\ud
capabilities. Third, it highlights areas for further research, such as the dynamics of CC, context-dependent\ud
motives and the emergence of professional (peer) service providers
Brief Report: Just-in-Time Visual Supports to Children with Autism via the Apple Watch:® A Pilot Feasibility Study

Using augmented input might be an effective means for supplementing spoken language for children with autism who have difficulties following spoken directives. This study aimed to (a) explore whether JIT-delivered scene cues (photos, video clips) via the Apple Watch® enable children with autism to carry out directives they were unable to implement with speech alone, and (b) test the feasibility of the Apple Watch® (with a focus on display size). Results indicated that the hierarchical JIT supports enabled five children with autism to carry out the majority of directives. Hence, the relatively small display size of the Apple Watch does not seem to hinder children with autism to glean critical information from visual supports