pinecone/core-2020-05-10-deduplication huggingface dataset:
Observable neutron–antineutron oscillations in seesaw models of neutrino mass

AbstractWe show that in a large class of supersymmetric models with spontaneously broken B–L symmetry, neutron–antineutron oscillations occur at an observable level even though the scale of B–L breaking is very high, vB–L∼2×1016 GeV, as suggested by gauge coupling unification and neutrino masses. We illustrate this phenomenon in the context of a recently proposed class of seesaw models that solves the strong CP problem and the SUSY phase problem using parity symmetry. We obtain an upper limit on N–N̄ oscillation time in these models, τN–N̄⩽109–1010 s. This suggests that a modest improvement in the current limit on τN–N̄ of 0.86×108 s will either lead to the discovery of N–N̄ oscillations, or will considerably restrict the allowed parameter space of an interesting class of neutrino mass models
Non-intact families and diverging educational destinies: A decomposition analysis for Germany, Italy, the United Kingdom and the United States

AbstractWe examine whether the presence of non-intact families in society is related to increased inequality in educational attainment according to social background, as suggested by the ‘diverging destinies’ thesis. We analyze four countries, Germany, Italy, the United Kingdom, and the United States, that differ in the prevalence of non-intact families and in the strength of the negative association between growing up in a non-intact family and children's educational attainment. We use a Blinder-Oaxaca decomposition approach to calculate a ‘counterfactual’ estimate of differences in educational attainment between socioeconomically advantaged and disadvantaged children in the hypothetical absence of non-intact families. Contrary to the diverging destinies thesis, we find little differences between actual and ‘counterfactual’ levels of inequality in educational attainment in all four countries. Whereas growing-up in a non-intact family affects the individual chances of educational attainment, the overall contribution of non-intact families to aggregate levels of social background inequality appears minimal
Standardized F1 – A consistent measure of strength of modulation of visual responses to sine-wave drifting gratings

AbstractThe magnitude of spike-responses of neurons in the mammalian visual system to sine-wave luminance-contrast-modulated drifting gratings is modulated by the temporal frequency of the stimulation. However, there are serious problems with consistency and reliability of the traditionally used methods of assessment of strength of such modulation. Here we propose an intuitive and simple tool for assessment of the strength of modulations in the form of standardized F1 index, zF1. We define zF1 as the ratio of the difference between the F1 (component of amplitude spectrum of the spike-response at temporal frequency of stimulation) and the mean value of spectrum amplitudes to standard deviation along all frequencies in the spectrum. In order to assess the validity of this measure, we have: (1) examined behavior of zF1 using spike-responses to optimized drifting gratings of single neurons recorded from four ‘visual’ structures (area V1 of primary visual cortex, superior colliculus, suprageniculate nucleus and caudate nucleus) in the brain of commonly used visual mammal – domestic cat; (2) compared the behavior of zF1 with that of classical statistics commonly employed in the analysis of steady-state responses; (3) tested the zF1 index on simulated spike-trains generated with threshold-linear model. Our analyses indicate that zF1 is resistant to distortions due to the low spike count in responses and therefore can be particularly useful in the case of recordings from neurons with low firing rates and/or low net mean responses. While most V1 and a half of caudate neurons exhibit high zF1 indices, the majorities of collicular and suprageniculate neurons exhibit low zF1 indices. We conclude that despite the general shortcomings of measuring strength of modulation inherent in the linear system approach, zF1 can serve as a sensitive and easy to interpret tool for detection of modulation and assessment of its strength in responses of visual neurons
Rapidity asymmetry in high-energy d+A collisions

AbstractIn contrast to the recent prediction of high pT hadron suppression within the parton saturation model, it is shown that multiple parton scattering suffered by the projectile will enhance high pT hadron spectra in d+A collisions relative to a superposition of binary p+p collisions at RHIC. A stronger enhancement in the forward rapidity region of the projectile is also predicted, resulting in a unique rapidity asymmetry of the hadron spectra at high pT. The shape of the rapidity asymmetry should be reversed for low pT hadrons that are dominated by soft and coherent interactions which suppress hadron spectra in the projectile rapidity region. The phenomenon at the LHC energies is shown to be qualitatively different because of parton shadowing
Experiences of hearing voices: analysis of a novel phenomenological survey

SummaryBackgroundAuditory hallucinations—or voices—are a common feature of many psychiatric disorders and are also experienced by individuals with no psychiatric history. Understanding of the variation in subjective experiences of hallucination is central to psychiatry, yet systematic empirical research on the phenomenology of auditory hallucinations remains scarce. We aimed to record a detailed and diverse collection of experiences, in the words of the people who hear voices themselves.MethodsWe made a 13 item questionnaire available online for 3 months. To elicit phenomenologically rich data, we designed a combination of open-ended and closed-ended questions, which drew on service-user perspectives and approaches from phenomenological psychiatry, psychology, and medical humanities. We invited people aged 16–84 years with experience of voice-hearing to take part via an advertisement circulated through clinical networks, hearing voices groups, and other mental health forums. We combined qualitative and quantitative methods, and used inductive thematic analysis to code the data and χ2 tests to test additional associations of selected codes.FindingsBetween Sept 9 and Nov 29, 2013, 153 participants completed the study. Most participants described hearing multiple voices (124 [81%] of 153 individuals) with characterful qualities (106 [69%] individuals). Less than half of the participants reported hearing literally auditory voices—70 (46%) individuals reported either thought-like or mixed experiences. 101 (66%) participants reported bodily sensations while they heard voices, and these sensations were significantly associated with experiences of abusive or violent voices (p=0·024). Although fear, anxiety, depression, and stress were often associated with voices, 48 (31%) participants reported positive emotions and 49 (32%) reported neutral emotions. Our statistical analysis showed that mixed voices were more likely to have changed over time (p=0·030), be internally located (p=0·010), and be conversational in nature (p=0·010).InterpretationThis study is, to our knowledge, the largest mixed-methods investigation of auditory hallucination phenomenology so far. Our survey was completed by a diverse sample of people who hear voices with various diagnoses and clinical histories. Our findings both overlap with past large-sample investigations of auditory hallucination and suggest potentially important new findings about the association between acoustic perception and thought, somatic and multisensorial features of auditory hallucinations, and the link between auditory hallucinations and characterological entities.FundingWellcome Trust
150years of macronutrient change in unfertilized UK ecosystems: Observations vs simulations

AbstractUnderstanding changes in plant-soil C, N and P using data alone is difficult due to the linkages between carbon, nitrogen and phosphorus cycles (C, N and P), and multiple changing long-term drivers (e.g. climate, land-use, and atmospheric N deposition). Hence, dynamic models are a vital tool for disentangling these drivers, helping us understand the dominant processes and drivers and predict future change. However, it is essential that models are tested against data if their outputs are to be concluded upon with confidence. Here, a simulation of C, N and P cycles using the N14CP model was compared with time-series observations of C, N and P in soils and biomass from the Rothamsted Research long-term experiments spanning 150years, providing an unprecedented temporal integrated test of such a model. N14CP reproduced broad trends in soil organic matter (SOM) C, N and P, vegetation biomass and N and P leaching. Subsequently, the model was used to decouple the effects of land management and elevated nitrogen deposition in these experiments. Elevated N deposition over the last 150years is shown to have increased net primary productivity (NPP) 4.5-fold and total carbon sequestration 5-fold at the Geescroft Wilderness experiment, which was re-wilded to woodland in 1886. In contrast, the model predicts that for cropped grassland conditions at the Park Grass site, elevated N deposition has very little effect on SOM, as increases in NPP are diverted from the soil. More broadly, these results suggest that N deposition is likely to have had a large effect on SOM and NPP in northern temperate and boreal semi-natural grasslands and forests. However, in cropped and grazed systems in the same region, whilst NPP may have been supported in part by elevated N deposition, declines in SOM may not have been appreciably counteracted by increased N availability
Kinetics and Mechanics of Two-Dimensional Interactions between T Cell Receptors and Different Activating Ligands

AbstractAdaptive immune responses are driven by interactions between T cell antigen receptors (TCRs) and complexes of peptide antigens (p) bound to Major Histocompatibility Complex proteins (MHC) on the surface of antigen-presenting cells. Many experiments support the hypothesis that T cell response is quantitatively and qualitatively dependent on the so-called strength of TCR/pMHC association. Most available data are correlations between binding parameters measured in solution (three-dimensional) and pMHC activation potency, suggesting that full lymphocyte activation required a minimal lifetime for TCR/pMHC interaction. However, recent reports suggest important discrepancies between the binding properties of ligand-receptor couples measured in solution (three-dimensional) and those measured using surface-bound molecules (two-dimensional). Other reports suggest that bond mechanical strength may be important in addition to kinetic parameters. Here, we used a laminar flow chamber to monitor at the single molecule level the two-dimensional interaction between a recombinant human TCR and eight pMHCs with variable potency. We found that 1), two-dimensional dissociation rates were comparable to three-dimensional parameters previously obtained with the same molecules; 2), no significant correlation was found between association rates and activating potency of pMHCs; 3), bond mechanical strength was partly independent of bond lifetime; and 4), a suitable combination of bond lifetime and bond strength displayed optimal correlation with activation efficiency. These results suggest possible refinements of contemporary models of signal generation by T cell receptors. In conclusion, we reported, for the first time to our knowledge, the two-dimensional binding properties of eight TCR/pMHC couples in a cell-free system with single bond resolution
Economics and Outcome After Hematopoietic Stem Cell Transplantation: A Retrospective Cohort Study

AbstractHematopoietic stem cell transplantation (HSCT) is a lifesaving expensive medical procedure. Hence, more transplants are performed in more affluent countries. The impact of economic factors on patient outcome is less defined. We analyzed retrospectively a defined cohort of 102,549 patients treated with an allogeneic (N=37,542; 37%) or autologous (N=65,007; 63%) HSCT. They were transplanted by one of 404 HSCT centers in 25 European countries between 1999 and 2006. We searched for associations between center-specific microeconomic or country-specific macroeconomic factors and outcome. Center patient-volume and center program-duration were significantly and systematically associated with improved survival after allogeneic HSCT (HR 0·87; 0·84–0·91 per 10 patients; p<0·0001; HR 0·90;0·85–0·90 per 10years; p<0·001) and autologous HSCT (HR 0·91;0·87–0·96 per 10 patients; p<0·001; HR 0·93;0·87–0·99 per 10years; p=0·02). The product of Health Care Expenditures by Gross National Income/capita was significantly associated in multivariate analysis with all endpoints (R2=18%; for relapse free survival) after allogeneic HSCT. Data indicate that country- and center-specific economic factors are associated with distinct, significant, systematic, and clinically relevant effects on survival after HSCT. They impact on center expertise in long-term disease and complication management. It is likely that these findings apply to other forms of complex treatments
c-function and central charge of the sine-Gordon model from the non-perturbative renormalization group flow

AbstractIn this paper we study the c-function of the sine-Gordon model taking explicitly into account the periodicity of the interaction potential. The integration of the c-function along trajectories of the non-perturbative renormalization group flow gives access to the central charges of the model in the fixed points. The results at vanishing frequency β2, where the periodicity does not play a role, are retrieved and the independence on the cutoff regulator for small frequencies is discussed. Our findings show that the central charge obtained integrating the trajectories starting from the repulsive low-frequencies fixed points (β2<8π) to the infra-red limit is in good quantitative agreement with the expected Δc=1 result. The behavior of the c-function in the other parts of the flow diagram is also discussed. Finally, we point out that including also higher harmonics in the renormalization group treatment at the level of local potential approximation is not sufficient to give reasonable results, even if the periodicity is taken into account. Rather, incorporating the wave-function renormalization (i.e. going beyond local potential approximation) is crucial to get sensible results even when a single frequency is used
Isomorphisms in pro-categories

AbstractA morphism of a category which is simultaneously an epimorphism and a monomorphism is called a bimorphism. In (Dydak and Ruiz del Portal (Monomorphisms and epimorphisms in pro-categories, preprint)) we gave characterizations of monomorphisms (resp. epimorphisms) in arbitrary pro-categories, pro-C, where C has direct sums (resp. weak push-outs). In this paper, we introduce the notions of strong monomorphism and strong epimorphism. Part of their significance is that they are preserved by functors. These notions and their characterizations lead us to important classical properties and problems in shape and pro-homotopy. For instance, strong epimorphisms allow us to give a categorical point of view of uniform movability and to introduce a new kind of movability, the sequential movability. Strong monomorphisms are connected to a problem of K. Borsuk regarding a descending chain of retracts of ANRs. If f:X→Y is a bimorphism in the pointed shape category of topological spaces, we prove that f is a weak isomorphism and f is an isomorphism provided Y is sequentially movable and X or Y is the suspension of a topological space. If f:X→Y is a bimorphism in the pro-category pro-H0 (consisting of inverse systems in H0, the homotopy category of pointed connected CW complexes) we show that f is an isomorphism provided Y is sequentially movable
Voxel-based clustered imaging by multiparameter diffusion tensor images for glioma grading

AbstractGliomas are the most common intra-axial primary brain tumour; therefore, predicting glioma grade would influence therapeutic strategies. Although several methods based on single or multiple parameters from diagnostic images exist, a definitive method for pre-operatively determining glioma grade remains unknown. We aimed to develop an unsupervised method using multiple parameters from pre-operative diffusion tensor images for obtaining a clustered image that could enable visual grading of gliomas. Fourteen patients with low-grade gliomas and 19 with high-grade gliomas underwent diffusion tensor imaging and three-dimensional T1-weighted magnetic resonance imaging before tumour resection. Seven features including diffusion-weighted imaging, fractional anisotropy, first eigenvalue, second eigenvalue, third eigenvalue, mean diffusivity and raw T2 signal with no diffusion weighting, were extracted as multiple parameters from diffusion tensor imaging. We developed a two-level clustering approach for a self-organizing map followed by the K-means algorithm to enable unsupervised clustering of a large number of input vectors with the seven features for the whole brain. The vectors were grouped by the self-organizing map as protoclusters, which were classified into the smaller number of clusters by K-means to make a voxel-based diffusion tensor-based clustered image. Furthermore, we also determined if the diffusion tensor-based clustered image was really helpful for predicting pre-operative glioma grade in a supervised manner. The ratio of each class in the diffusion tensor-based clustered images was calculated from the regions of interest manually traced on the diffusion tensor imaging space, and the common logarithmic ratio scales were calculated. We then applied support vector machine as a classifier for distinguishing between low- and high-grade gliomas. Consequently, the sensitivity, specificity, accuracy and area under the curve of receiver operating characteristic curves from the 16-class diffusion tensor-based clustered images that showed the best performance for differentiating high- and low-grade gliomas were 0.848, 0.745, 0.804 and 0.912, respectively. Furthermore, the log-ratio value of each class of the 16-class diffusion tensor-based clustered images was compared between low- and high-grade gliomas, and the log-ratio values of classes 14, 15 and 16 in the high-grade gliomas were significantly higher than those in the low-grade gliomas (p < 0.005, p < 0.001 and p < 0.001, respectively). These classes comprised different patterns of the seven diffusion tensor imaging-based parameters. The results suggest that the multiple diffusion tensor imaging-based parameters from the voxel-based diffusion tensor-based clustered images can help differentiate between low- and high-grade gliomas
Study of inclusive J/ψ production in two-photon collisions at LEP II with the DELPHI detector

AbstractInclusive J/ψ production in photon–photon collisions has been observed at LEP II beam energies. A clear signal from the reaction γγ→J/ψ+X is seen. The number of observed N(J/ψ→μ+μ−) events is 36±7 for an integrated luminosity of 617 pb−1, yielding a cross-section of σ(J/ψ+X)=45±9(stat)±17(syst) pb. Based on a study of the event shapes of different types of γγ processes in the PYTHIA program, we conclude that (74±22)% of the observed J/ψ events are due to ‘resolved’ photons, the dominant contribution of which is most probably due to the gluon content of the photon
Modelling the enigmatic Late Pliocene Glacial Event — Marine Isotope Stage M2

AbstractThe Pliocene Epoch (5.2 to 2.58Ma) has often been targeted to investigate the nature of warm climates. However, climate records for the Pliocene exhibit significant variability and show intervals that apparently experienced a cooler than modern climate. Marine Isotope Stage (MIS) M2 (~3.3Ma) is a globally recognisable cooling event that disturbs an otherwise relatively (compared to present-day) warm background climate state. It remains unclear whether this event corresponds to significant ice sheet build-up in the Northern and Southern Hemisphere. Estimates of sea level for this interval vary, and range from modern values to estimates of 65m sea level fall with respect to present day. Here we implement plausible M2 ice sheet configurations into a coupled atmosphere–ocean climate model to test the hypothesis that larger-than-modern ice sheet configurations may have existed at M2. Climate model results are compared with proxy climate data available for M2 to assess the plausibility of each ice sheet configuration. Whilst the outcomes of our data/model comparisons are not in all cases straight forward to interpret, there is little indication that results from model simulations in which significant ice masses have been prescribed in the Northern Hemisphere are incompatible with proxy data from the North Atlantic, Northeast Arctic Russia, North Africa and the Southern Ocean. Therefore, our model results do not preclude the possibility of the existence of larger ice masses during M2 in the Northern or Southern Hemisphere. Specifically they are not able to discount the possibility of significant ice masses in the Northern Hemisphere during the M2 event, consistent with a global sea-level fall of between 40m and 60m. This study highlights the general need for more focused and coordinated data generation in the future to improve the coverage and consistency in proxy records for M2, which will allow these and future M2 sensitivity tests to be interrogated further
Space–time torsion contribution to quantum interference phases

AbstractThe field of neutron interferometry achieved one of its most significant successes with the detection of the influence of gravity in the quantum mechanical phase of a thermal neutron beam. From the latest experimental readouts in this context an intriguing discrepancy has been elicited. Indeed, theory and experiment dissent by one per cent, and though this fact could be a consequence of the mounting of the experimental device, it might also embody a difference between the way in which gravity behaves in classical and quantum mechanics. In this work the effects, upon the interference pattern, of space–time torsion will be analyzed heeding its coupling with the spin of the neutron beam. It will be proved that, even with this contribution, there is enough leeway for a further discussion of the validity of the equivalence principle in nonrelativistic quantum mechanics
Glucocorticoid influence on prognosis of idiopathic sudden sensorineural hearing loss

AbstractIntroductionIdiopathic Sudden Sensorineural Hearing Loss (ISSHL) is defined when a loss of at least 30dB occurs in over 3 continuous frequencies, in up to 72hours, of which etiology is not established, despite adequate investigation. Different types of treatment regimens have been proposed, but only glucocorticoids have shown some evidence of benefit in the literature.ObjectiveTo analyze whether the type of treatment or time of treatment with glucocorticoids have any influence on hearing recovery in ISSHL.MethodsObservational retrospective cohort study. One hundred twenty-seven patients with ISSHL, treated at outpatient clinics between the years 2000 and 2010, were studied. We evaluated the prognostic correlation of the type of treatment and time to treatment with glucocorticoids and ISSHL.ResultsThe absolute hearing gain and the relative hearing gain was as follows: 23.6dB and 37.2%. Complete recovery was observed in 15.7% of patients, significant recovery in 27.6% and recovery in 57.5%.ConclusionIn this study, there was no difference between the use and nonuse of glucocorti- coids in hearing improvement. However, when started within seven days after onset, the use of glucocorticoids was a factor of better prognosis