pinecone/core-2020-05-10-deduplication huggingface dataset:
The secreted protein C1QL1 and its receptor BAI3 control the synaptic connectivity of excitatory inputs converging on cerebellar Purkinje cells
 : 
C1QL1/BAI3 and neuronal connectivity

International audiencePrecise patterns of connectivity are established by different types of afferents on a given target neuron, leading to well-defined and non-overlapping synaptic territories. What regulates the specific characteristics of each type of synapse, in terms of number, morphology and subcellular localization, remains to be understood. Here we show that the signaling pathway formed by the secreted complement C1Q-related protein C1QL1 and its receptor, the adhesion-GPCR Brain Angiogenesis Inhibitor 3 (BAI3), control the stereotyped pattern of connectivity established by excitatory afferents on cerebellar Purkinje cells. The BAI3 receptor modulates synaptogenesis of both parallel fiber and climbing fiber afferents. The restricted and timely expression of its ligand C1QL1 in inferior olivary neurons ensures the establishment of the proper synaptic territory for climbing fibers. Given the broad expression of C1QL and BAI proteins in the developing mouse brain, our study reveals a general mechanism contributing to the formation of a functional brain
From Nerode's congruence to Suffix Automata with mismatches

International audienceIn this paper we focus on the minimal deterministic finite automaton S k that recognizes the set of suffixes of a word w up to k errors. As first results we give a characterization of the Nerode's right-invariant congruence that is associated with S_k. This result generalizes the classical characterization described in [5]. As second result we present an algorithm that makes use of S_k to accept in an efficient way the language of all suffixes of w up to k errors in every window of size r of a text, where r is the repetition index of w. Moreover, we give some experimental results on some well-known words, like prefixes of Fibonacci and Thue-Morse words. Finally, we state a conjecture and an open problem on the size and the construction of the suffix automaton with mismatches
The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct atomic force microscopy visualization of variant chromatin.

International audienceChromatin organization and dynamics is studied at scales ranging from single nucleosome to nucleosomal array by using a unique combination of biochemical assays, single molecule imaging technique, and numerical modeling. We show that a subtle modification in the nucleosome structure induced by the histone variant H2A.Bbd drastically modifies the higher order organization of the nucleosomal arrays. Importantly, as directly visualized by atomic force microscopy, conventional H2A nucleosomal arrays exhibit specific local organization, in contrast to H2A.Bbd arrays, which show "beads on a string" structure. The combination of systematic image analysis and theoretical modeling allows a quantitative description relating the observed gross structural changes of the arrays to their local organization. Our results suggest strongly that higher-order organization of H1-free nucleosomal arrays is determined mainly by the fluctuation properties of individual nucleosomes. Moreover, numerical simulations suggest the existence of attractive interactions between nucleosomes to provide the degree of compaction observed for conventional chromatin fibers
Heavy quark energy loss and D-Mesons at RHIC and LHC energies

We obtain the radiative energy loss of a heavy quark in a deconfined medium
due to radiation of gluons off them using a recently derived generalised gluon
emission spectrum. We find that the heavy flavour loses energy almost in a
similar fashion like light quarks through this process. With this, we further
analyse the nuclear modification factor for D-meson at LHC and RHIC energies.
In particular, the obtained result is found to be in close agreement with the
most recent data from ALICE collaboration at 2.76 ATeV Pb-Pb collisions. We
also discuss the nuclear modification factor due to the collisional energy
loss. Furthermore, the result of non-photonic single electron from the decay of
both D and B mesons is compared with the RHIC data at 200 AGeV Au-Au
collisions, which is also in close agreement.Comment: Non-photonic single electron results included, title changed a bit,
  version accepted in Phys. Lett.
Probing Orientational Order of MHC Class I Protein and Lipids in Cell Membranes by Fluorescence Polarization-Resolved Microscopy Imaging

International audienceSteady-state polarization-resolved fluorescence imaging is used to analyze the molecular orientational order behavior of rigidly labeled major histocompatibility complex class I (MHC I) proteins and lipid probes in cell membranes of living cells. These fluorescent probes report the orientational properties of proteins and their surrounding lipid environment. We present a statistical study of the molecular orientational order, modeled as the width of the angular distribution of the molecules, for the proteins in the cell endomembrane and plasma membrane, as well as for the lipid probes in the plasma membrane. We apply this methodology on cells after treatments affecting the actin and microtubule networks. We find in particular opposite orientational order changes of proteins and lipid probes in the plasma membrane as a response to the cytoskeleton disruption. This suggests that MHC I orientational order is governed by its interaction with the cytoskeleton, whereas the plasma membrane lipid order is governed by the local cell membrane morphology
Evidence for several dipolar quasi-invariants in liquid crystals

In a closed quantum system of N dipole coupled spins with magnetic quantum number I, there are (2I +1)N constants of motion, however, the possibility of observing such quasi-invariants (QIs) in solid-like spin systems in Nuclear Magnetic Resonance (NMR) is not a strictly exact prediction. The aim of this work is to provide experimental evidence of several QIs, in the proton NMR of small spin clusters, besides those already known Zeeman, and dipolar orders (strong and weak). We  explore the spin states prepared with the Jeener-Broekaert pulse sequence by analyzing the timedomain signals yielded by this sequence as a function of the preparation times, in a variety of dipolar  networks, solids and liquid crystals. We observe that the signals can be explained with two dipolar QIs only within a range of short preparation times. At longer times liquid crystal signals show an echo-like behaviour. We study their multiple quantum coherence content on a basis orthogonal to the z-basis and see that such states involve a signiﬁcant number of correlated spins. Then we show that the NMR signals within the whole preparation time-scale can only be reconstructed by  assuming the occurrence of multiple QIs which we experimentally isolate.Fil: Bonin, Claudio Julio. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; ArgentinaFil: González, C. E.. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Física "Enrique Gaviola"; ArgentinaFil: Segnorile, Hector Hugo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Física "Enrique Gaviola"; ArgentinaFil: Zamar, Ricardo César. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Física "Enrique Gaviola"; Argentin
Distributed approximation of open-channel flow routing accounting for backwater effects

International audienceIn this article, we propose a new model, called LBLR for Linear Backwater Lag-and-Route, which approximates the Saint-Venant equations linearized around a non-uniform flow in a finite channel (with a downstream boundary condition). A classical frequency approach is used to build the distributed Saint-Venant transfer function providing the discharge at any point in the channel in the Laplace domain with respect to the upstream discharge. The moment matching method is used to match a second-order-with- delay model on the theoretical distributed Saint-Venant transfer function. Model parameters are then expressed analytically as functions of the pool characteristics. The proposed model efficiently accounts for the effects of downstream boundary condition on the channel dynamics
Locating a weak change using diffuse waves: Theoretical approach and inversion procedure

International audienceWe describe a time-resolved monitoring technique for heterogeneous media. Our approach is based on the spatial variations of the cross-coherence of diffuse waves acquired at fixed positions but at different dates. The technique applies to all kind of waves, provided that waveforms can be acquired with a sampling frequency much larger than the wave frequency. To locate and characterize a weak change that occurred between successive acquisitions, we use a maximum likelihood approach combined with a diffusive propagation model. We characterize this technique, locating a weak change using diffuse waves, called LOCADIFF, with the aid of numerical simulations. In several illustrative examples, we show that the change can be located with a precision of a few wavelengths and that its effective scattering cross-section can be retrieved. We investigate how the accuracy and precision of the method depends on the number of source-receiver pairs, on the time window used to compute the cross-correlation and on the errors in the propagation model. Applications can be found in nondestructive testing, seismology, radar, and sonar location
Enhanced tonic GABAA inhibition in typical absence epilepsy

The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired gamma-aminobutyric acid (GABA)-ergic inhibition remains an attractive hypothesis. In contrast, we show here that extrasynaptic GABA(A) receptor-dependent 'tonic' inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures. Increased tonic inhibition is due to compromised GABA uptake by the GABA transporter GAT-1 in the genetic models tested, and GAT-1 is crucial in governing seizure genesis. Extrasynaptic GABA(A) receptors are a requirement for seizures in two of the best characterized models of absence epilepsy, and the selective activation of thalamic extrasynaptic GABA(A) receptors is sufficient to elicit both electrographic and behavioral correlates of seizures in normal rats. These results identify an apparently common cellular pathology in typical absence seizures that may have epileptogenic importance and highlight potential therapeutic targets for the treatment of absence epilepsy
A refined Jensen's inequality in Hilbert spaces and empirical approximations

Let f : (sic) -> R be a convex mapping and (sic) a Hilbert space. In this paper we prove the following refinement of Jensen's inequality: E(f vertical bar X is an element of A) >= E(f vertical bar X is an element of B) for every A, B such that E(f vertical bar X is an element of A) >= E(f vertical bar X is an element of B) and B subset of A. Expectation 5 of Hilbert-space-valued random elements are defined by means of the Pettis integrals. Our result generalizes a result of [S. Karlin, A. Novikoff, Generalized convex inequalities, Pacific J. Math. 13 (1963) 1251-1279], who derived it for (sic) = R. The inverse implication is also true if P is an absolutely continuous probability measure. A convexity criterion based on the Jensen-type inequalities follows and we study its asymptotic accuracy when the empirical distribution function based on an n-dimensional sample approximates the unknown distribution function. Some statistical applications are addressed, such as nonparametric estimation and testing for convex regression functions or other functionals. (C) 2008 Elsevier Inc. All rights reserved
Periodic solutions for completely resonant nonlinear wave equations with Dirichlet boundary conditions

We consider the nonlinear string equation with Dirichlet boundary conditions utt–uxx=(u), with (u)=u3+O(u5) odd and analytic, 0, and we construct small amplitude periodic solutions with frequency  for a large Lebesgue measure set of  close to 1. This extends previous results where only a zero-measure set of frequencies could be treated (the ones for which no small divisors appear). The proof is based on combining the Lyapunov-Schmidt decomposition, which leads to two separate sets of equations dealing with the resonant and non-resonant Fourier components, respectively the Q and the P equations, with resummation techniques of divergent powers series, allowing us to control the small divisors problem. The main difficulty with respect to the nonlinear wave equations utt–uxx+Mu=(u), M0, is that not only the P equation but also the Q equation is infinite-dimensional
Combined search for the standard model Higgs boson using up to 4.9 fb(-1) of pp collision data at root s=7 TeV with the ATLAS detector at the LHC

A combined search for the Standard Model Higgs boson with the ATLAS experiment at the LHC using datasets corresponding to integrated luminosities from 1.04 fb^(−1) to 4.9 fb^(−1) of pp collisions collected at sqrt(s) = 7 TeV is presented. The Higgs boson mass ranges 112.9–115.5 GeV, 131–238 GeV and 251–466 GeV are excluded at the 95% confidence level (CL), while the range 124–519 GeV is expected to be excluded in the absence of a signal. An excess of events is observed around m(H) ∼ 126 GeV with a local significance of 3.5 standard deviations (σ). The local significances of H →γγ, H → Z Z(∗) →l+ l− l'+ l'− and H →WW(∗) →l+ ν l'− bar(ν) , the three most sensitive channels in this mass range, are 2.8σ, 2.1σ and 1.4σ, respectively. The global probability for the background to produce such a fluctuation anywhere in the explored Higgs boson mass range 110–600 GeV is estimated to be ∼ 1.4% or, equivalently, 2.2σ
Effect of freeze-thaw cycles on the hydraulic conductivity of a compacted clayey silt and influence of the compaction energy

Compacted clay layers are often used in impervious barrier systems to prevent the migration of water and pollutants. Environmental factors, acting during or after the clay deposition, may affect the layer integrity and induce a variation of hydraulic conductivity over time. The aim of the present research is to assess this variation when induced by freeze–thaw cycles. The paper summarizes some results of tests performed on a series of clayey silt samples, reconstituted at various levels of compaction energy and subjected to cyclic freezing according to a controlled and repeatable procedure, set to reproduce the natural environmental conditions. The hydraulic conductivity is evaluated directly from a flexible wall permeameter and indirectly from oedometric tests. The results show the consequences of cyclic freezing in relation to the compaction level and lead to insights into the development of fracture networks responsible for the increase in hydraulic conductivity
The dark matter distribution in the spiral NGC 3198 out to 0.22 R-vir

Aims. We use recent very extended HI kinematics (out to 48 kpc) along with previous H alpha kinematics of the spiral galaxy NGC 3198 in order to derive its distribution of dark matter (DM). 
Methods. First, we used a chi-square method to model the rotation curve (RC) of this galaxy in terms of different profiles of its DM distribution: the universal RC (URC) mass model (stellar disk + Burkert halo + gaseous disk), the NFW mass model (stellar disk + NFW halo + gaseous disk) and the baryon Lambda CDM mass model (stellar disk + NFW halo modified by baryonic physics + gaseous disk). Second, to derive the DM halo density distribution, we applied a new method that does not require a global and often uncertain mass modelling. 
Results. While according to the standard method, both URC and NFW mass models can account for the RC, the new method instead leads to a density profile that is sharply disagrees with the dark halo density distribution predicted within the Lambda cold dark matter (Lambda CDM) scenario. We find that the effects of baryonic physics modify the original Lambda CDM halo densities in such a way that the resulting profile is more compatible with the DM density of NGC 3198 derived using our new method. However, at large distances, r similar to 25 kpc, also this modified baryon Lambda CDM halo profile appears to create a tension with the derived DM halo density
History of quaternion and Clifford-fourier transforms and wavelets

The development of hypercomplex Fourier transforms and wavelets has taken place in several different threads, reflected in the overview of the subject presented in this chapter. We present in Section 1 an overview of the development of quaternion Fourier transforms, then in Section 2 the development of Clifford Fourier transforms. Finally, since wavelets are a more recent development, and the distinction between their quaternion and Cliord algebra approach has been much less pronounced than in the case of Fourier transforms, Section 3 reviews the history of both quaternion and Clifford wavelets
Measurement of the t-channel single top-quark production cross section in pp collisions at √s=7 TeV with the ATLAS detector

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMWe report a measurement of the cross section of single top-quark production in the t-channel using 1.04 fb−1 of pp collision data at √ s = 7 TeV recorded with the ATLAS detector at the LHC. Selected events feature one electron or muon, missing transverse momentum, and two or three jets, exactly one of them identified as originating from a b quark. The cross section is measured by fitting the distribution of a multivariate discriminant constructed with a neural network, yielding σt = 83±4 (stat.) +20 −19 (syst.) pb, which is in good agreement with the prediction of the Standard Model. Using the ratio of the measured to the theoretically predicted cross section and assuming that the top-quark-related CKM matrix elements obey the relation |Vtb|>>|Vts|, |Vtd|, the coupling strength at the W-t-b vertex is determined to be |Vtb| = 1.13+0.14 −0.13. If it is assumed that |Vtb| ≤ 1 a lower limit of |Vtb| > 0.75 is obtained at the 95% confidence levelWe acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET and ERC, European Union; IN2P3–CNRS, CEA-DSM/IRFU, France; GNAS, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT, Greece; ISF, MINERVA, GIF, DIP and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN and the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway,
Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA) and in the Tier-2 facilities worldwid
Measurement of Wγ and Zγ production cross sections in pp collisions at s=7TeV and limits on anomalous triple gauge couplings with the ATLAS detector

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMThis Letter presents measurements of l±νγ and l+l−γ (l = e,μ) production in 1.02 fb−1 of pp collision data recorded at √ s = 7 TeV with the ATLAS detector at the LHC in the first half of 2011. Events dominated by Wγ and Zγ production with leptonic decays of the W and Z bosons are selected, and their production cross sections and kinematic properties are measured in several ranges of the photon transverse energy. The results are compared to Standard Model predictions and are used to determine limits on anomalous WWγ and Z Zγ /Zγγ couplingsWe acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET and ERC, European Union; IN2P3–CNRS, CEA-DSM/IRFU, France; GNAS, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT, Greece; ISF, MINERVA, GIF, DIP and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of Americ
Developing a fuzzy multicriteria decision-making model for selecting design-build operational variations

Many academic researchers have conducted studies on the selection of a design-build (DB) delivery method; however, there are few studies on the selection of DB operational variations, which pose challenges to many clients. The selection of a DB operational variation is a multicriteria decision-making process that requires clients to objectively evaluate the performance of each DB operational variation with reference to the selection criteria. This evaluation process is often characterized by subjectivity and uncertainty. To resolve this deficiency, the current investigation aimed to establish a fuzzy multicriteria decision-making (FMCDM) model for selecting the most suitable DB operational variation. A three-round Delphi questionnaire survey was conducted to identify the selection criteria and their relative importance. A fuzzy set theory approach, namely, the modified horizontal approach with the bisector error method, was applied to establish the fuzzy membership functions, which enables clients to perform quantitative calculations on the performance of each DB operational variation. The FMCDM was developed using the weighted-mean method to aggregate the overall performance of DB operational variations with regard to the selection criteria. The proposed FMCDM model enables clients to perform quantitative calculations in a fuzzy decision-making environment and provides a useful tool to cope with different project attributes.Department of Building and Real EstateAuthor name used in this publication: John F. Y. Yeung2011-2012 > Academic research: refereed > Publication in refereed journalpreprint_postprin