pinecone/core-2020-05-10-deduplication huggingface dataset:
Assembling models of embryo development: Image analysis and the construction of digital atlases

Digital atlases of animal development provide a quantitative description of morphogenesis, opening the path toward processes modeling. Prototypic atlases offer a data integration framework where to gather information from cohorts of individuals with phenotypic variability. Relevant information for further theoretical reconstruction includes measurements in time and space for cell behaviors and gene expression. The latter as well as data integration in a prototypic model, rely on image processing strategies. Developing the tools to integrate and analyze biological multidimensional data are highly relevant for assessing chemical toxicity or performing drugs preclinical testing. This article surveys some of the most prominent efforts to assemble these prototypes, categorizes them according to salient criteria and discusses the key questions in the field and the future challenges toward the reconstruction of multiscale dynamics in model organisms
Density and viscosity measurements of aqueous amines at high pressures: DEA-water, DMAE-water and TEA-water mixtures

Producción CientíficaIn this paper, density and viscosity measurements at pressures up to 140 MPa are presented in a temperatura range from (293.15 to 393.15) K for diethanolamine (DEA) + water, triethanolamine (TEA) + wáter and 2-dimethylaminoethanol (DMAE) + water in amine weight concentrations from 10% to 40%. Densities were measured using a vibrating tube densimeter (Anton Paar DMA HPM) with an expanded uncertainty (k = 2) less than ±0.7 kg m 3. Viscosity measurements were obtained using a falling body viscometer which was calibrated with water and dodecane. The viscosity expanded uncertainty (k = 2) ranges from ±2.5% for the highest viscosity to ±3.2% for the lowest.2019/05/052019Regional Government of Castilla y León through the Project VA295U1
Sensitivity Analysis of a Nonlinear Obstacle Plate Problem

We analyse the sensitivity of the solution of a nonlinear obstacle plate problem, with respect to small perturbations of the middle plane of the plate. This analysis, which generalizes the results of Rao and Sokolowski 1987, Rockafeller 1989 for the linear case, is done by application of an abstract variational result Levy 1999, where the sensitivity of parameterized variational inequalities in Banach spaces, without uniqueness of solution, is quantified in terms of a generalized derivative, that is the proto-derivative. We prove that the hypotheses required by this abstract sensitivity result are verified for the nonlinear obstacle plate problem. Namely, the constraint set defined by the obstacle is polyhedric and the mapping involved in the definition of the plate problem, considered as a function of the middle plane of the plate, is semi-differentiable. The verification of these two conditions enable to conclude that the sensitivity is characterized by the proto-derivative of the solution mapping associated with the nonlinear obstacle plate problem, in terms of the solution of a variational inequality.PRAXIS/PCEX/C/MAT/38/96 \Variational Models and Optimization", and Sapiens Proj99,
No. 34471 \Nonlinear Partial Di erential Equations and Interfaces Problems" of the Ministry of Science and Technology of
Portuga
The relevance of seed size in modulating leaf physiology and early plant performance in two tree species

he size of seeds and the microsite of seed dispersal may affect the early establishment of seedlings through different physiological processes. Here, we examined the effects of seed size and light availability on seedling growth and survival, and whether such effects were mediated by water use efficiency. Acorns of Quercus petraea and the more drought-tolerant Quercus pyrenaica were sowed within and around a tree canopy gap in a sub-Mediterranean forest stand. We monitored seedling emergence and measured predawn leaf water potential (Ψpd), leaf nitrogen per unit area (Na), leaf mass per area, leaf carbon isotope composition (δ13C) and plant growth at the end of the first summer. Survival was measured on the next year. Path analysis revealed a consistent pattern in both species of higher δ13C as Ψpd decreased and higher δ13C as seedlings emerged later in the season, indicating an increase in 13C as the growing season is shorter and drier. There was a direct positive effect of seed size on δ13C in Q. petraea that was absent in Q. pyrenaica. Leaf δ13C had no effect on growth but the probability of surviving until the second year was higher for those seedlings of Q. pyrenaica that had lower δ13C on the first year. In conclusion, leaf δ13C is affected by seed size, seedling emergence time and the availability of light and water, however, leaf δ13C is irrelevant for first year growth, which is directly dependent on the amount of seed reserves
Resummations and non-perturbative corrections

We consider a generalization of the Borel resummation, which turns out to be equivalent to the standard Borel resummation. We apply it to the simplest large N duality between the pure Chern-Simons theory and the topological string on the resolved conifold, and obtain a simple integral formula for the free energy. Expanding this integral representation around the large radius point at finite string coupling g s , we find that it includes not only the M-theoretic resummation à la Gopakumar and Vafa, but also a non-perturbative correction in g s . Remarkably, the obtained non-perturbative correction is in perfect agreement with a proposal for membrane instanton corrections in arXiv:​1306.​1734. Various other examples are also presented
On-chip III-V monolithic integration of heralded single photon sources and beamsplitters

We demonstrate a monolithic III-V photonic circuit combining a heralded single photon source with a beamsplitter, at room temperature and telecom wavelength. Pulsed parametric down- conversion in an AlGaAs waveguide generates counterpropagating photons, one of which is used to herald the injection of its twin into the beamsplitter. We use this configuration to implement an integrated Hanbury-Brown and Twiss experiment, yielding a heralded second-order correlation g ð 2 Þ her ð 0 Þ¼ 0 : 10 6 0 : 02 that confirms single-photon operation. The demonstrated generation and manipulation of quantum states on a single III-V semiconductor chip opens promising avenues towards real-world applications in quantum information
Brout-Englert-Higgs mechanism for accelerating observers

In this work we consider the spontaneous symmetry breaking of the electroweak SU(2)_(L) × U(1)_(Y) gauge group into U(1)_(em) taking place in the Standard Model of particle physics as seen from the point of view of an accelerating observer. According to the Unruh effect, that observer detects the Minkowski vacuum as a thermal bath at a temperature proportional to the proper acceleration a. Then we show that (in a certain large N limit) when the acceleration is bigger than the critical value a_(c) = 4πv (where v is the Higgs vacuum expectation value), the electroweak SU(2)L × U(1)_(Y) gauge symmetry is restored and all elementary particles become massless. In addition, even observers with a  ˂ a_(c) can see this symmetry restoration in the region close to the Rindler horizon
Content of health status reports of people seeking assisted suicide: a qualitative analysis

Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)Two right-to-die organisations offer assisted suicide in Switzerland. The specific legal situation allows assistance to Swiss and foreign citizens. Both organisations require a report of the person's health status before considering assistance. This qualitative study explored these reports filed to legal authorities after the deaths of individuals in the area of Zurich. Health status reports in the legal medical dossiers of the deceased were analysed using content analysis and Grounded Theory. From 421 cases of assisted suicide (2001-2004), 350 reports on health status were filed. Many cases contained diagnosis lists only. Other reports had more elaborate reports revealing that some physicians were aware about the patient's death wish and the intention to solicit assisted suicide. Physicians' attitudes ranged from neutral to rather depreciative. Few physicians openly referred the patient to the organisations and supported the patient's request by highlighting a history of suffering as well as reporting understanding and agreement with the patient's wish to hasten death. In the health status reports five categories could be identified. Some files revealed that physicians were aware of the death wish. The knowledge and recognition of the patient's death wish varied from no apparent awareness to strongly supportive. This variety might be due to difficulties to discuss the death wish with patients, but might also reflect the challenge to avoid legal prosecution in the country of origin. To require comparable health status reports as requirements for the right-to-die organisations might be difficult to pursue
Substituting a copper atom modifies the melting of aluminum clusters

Producción CientíficaHeat capacities have been measured for Al(n−1)Cu− clusters (n = 49–62) and compared with results for pure Aln+ clusters. Al(n−1)Cu− and Aln+ have the same number of atoms and the same number of valence electrons (excluding the copper d electrons). Both clusters show peaks in their heat capacities that can be attributed to melting transitions; however, substitution of an aluminum atom by a copper atom causes significant changes in the melting behavior. The sharp drop in the melting temperature that occurs between n = 55 and 56 for pure aluminum clusters does not occur for the Al(n−1)Cu− analogs. First-principles density-functional theory has been used to locate the global minimum energy structures of the doped clusters. The results show that the copper atom substitutes for an interior aluminum atom, preferably one with a local face-centered-cubic environment. Substitution does not substantially change the electronic or geometric structures of the host cluster unless there are several Aln+ isomers close to the ground state. The main structural effect is a contraction of the bond lengths around the copper impurity, which induces both a contraction of the whole cluster and a stress redistribution between the Al–Al bonds. The size dependence of the substitution energy is correlated with the change in the latent heat of melting on substitution
Cost optimization of singly and doubly reinforced concrete beams with EC2-2001

A model for the optimal design of rectangular reinforced concrete sections is presented considering the stress–strain diagrams described in EC2-2001 and MC90. The following expressions are developed: economic bending moment; optimal area of steel and optimal steel ratio between upper and lower steel. All the expressions are in nondimensional form. The present model is applied to four different classes of concrete described in MC90. It is concluded that in nondimensional form the equations are nearly coincident for both singly and doubly reinforcement. It is also concluded that the ultimate strain for concrete in the compression zone, ecm, lies between the strain for peak stress ec1 and the ultimate strain ecu. This result is relevant once that the maximum moment is obtained for this value, and not the value ecu, as defined in EC2-2001. Cost optimization is implemented in the code and compared with other optimum models based on the ultimate design of ACI.http://dx.doi.org/10.1007/s00158-005-0516-
Recursive n-gram hashing is pairwise independent, at best

Many applications use sequences of n consecutive symbols (n-grams). Hashing
these n-grams can be a performance bottleneck. For more speed, recursive hash
families compute hash values by updating previous values. We prove that
recursive hash families cannot be more than pairwise independent. While hashing
by irreducible polynomials is pairwise independent, our implementations either
run in time O(n) or use an exponential amount of memory. As a more scalable
alternative, we make hashing by cyclic polynomials pairwise independent by
ignoring n-1 bits. Experimentally, we show that hashing by cyclic polynomials
is is twice as fast as hashing by irreducible polynomials. We also show that
randomized Karp-Rabin hash families are not pairwise independent.Comment: See software at https://github.com/lemire/rollinghashcp
Existence of anisotropic spin fluctuations at low temperature in the normal phase of the superconducting ferromagnet UCoGe

Thermal conductivity measurements have been performed on the superconducting ferromagnet UCoGe down to very low temperature and under magnetic field. In addition to the electronic quasiparticle thermal conductivity, additional contributions to the thermal transport are detected: they are sensitive to the amplitude and direction of the magnetic field and at low temperature, they display a strong anisotropy with the heat current direction. We identify these contributions as arising from magnetic fluctuations. Detection of such fluctuations on the thermal transport in 3D weak ferromagnets is very rare if not unique and pledges for a strongly itinerant character of the magnetism of UCoGe
Toroidal Quadrupole Form Factor of the Deuteron

We calculate the toroidal quadrupole moment and form factor of the deuteron,
which violate time-reversal symmetry but conserve parity, at leading order in
two-flavor chiral effective field theory with perturbative pion exchange. We
take into account time-reversal and parity violation due to the QCD vacuum
angle combined with parity violation resulting from the weak interaction in the
Standard Model. We also consider time-reversal and parity violation that at the
quark-gluon level results from effective dimension-six operators originating
from physics beyond the Standard Model
Faster 64-bit universal hashing using carry-less multiplications

Intel and AMD support the Carry-less Multiplication (CLMUL) instruction set
in their x64 processors. We use CLMUL to implement an almost universal 64-bit
hash family (CLHASH). We compare this new family with what might be the fastest
almost universal family on x64 processors (VHASH). We find that CLHASH is at
least 60% faster. We also compare CLHASH with a popular hash function designed
for speed (Google's CityHash). We find that CLHASH is 40% faster than CityHash
on inputs larger than 64 bytes and just as fast otherwise
Short-rib polydactyly and jeune syndromes are caused by mutations in WDR60

Short-rib polydactyly syndromes (SRPS I-V) are a group of lethal congenital disorders characterized by shortening of the ribs and long bones, polydactyly, and a range of extraskeletal phenotypes. A number of other disorders in this grouping, including Jeune and Ellis-van Creveld syndromes, have an overlapping but generally milder phenotype. Collectively, these short-rib dysplasias (with or without polydactyly) share a common underlying defect in primary cilium function and form a subset of the ciliopathy disease spectrum. By using whole-exome capture and massive parallel sequencing of DNA from an affected Australian individual with SRPS type III, we detected two novel heterozygous mutations in <i>WDR60</i>, a relatively uncharacterized gene. These mutations segregated appropriately in the unaffected parents and another affected family member, confirming compound heterozygosity, and both were predicted to have a damaging effect on the protein. Analysis of an additional 54 skeletal ciliopathy exomes identified compound heterozygous mutations in <i>WDR60</i> in a Spanish individual with Jeune syndrome of relatively mild presentation. Of note, these two families share one novel <i>WDR60</i> missense mutation, although haplotype analysis suggested no shared ancestry. We further show that WDR60 localizes at the base of the primary cilium in wild-type human chondrocytes, and analysis of fibroblasts from affected individuals revealed a defect in ciliogenesis and aberrant accumulation of the GLI2 transcription factor at the centrosome or basal body in the absence of an obvious axoneme. These findings show that <i>WDR60</i> mutations can cause skeletal ciliopathies and suggest a role for WDR60 in ciliogenesis
On the determination of the leptonic CP phase

The combination of data from long-baseline and reactor oscillation experiments leads to a preference of the leptonic CP phase δ CP in the range between π and 2π. We study the statistical significance of this hint by performing a Monte Carlo simulation of the relevant data. We find that the distribution of the standard test statistic used to derive confidence intervals for δ CP is highly non-Gaussian and depends on the unknown true values of θ 23 and the neutrino mass ordering. Values of δ CP around π/2 are disfavored at between 2σ and 3σ, depending on the unknown true values of θ 23 and the mass ordering. Typically the standard χ 2 approximation leads to over-coverage of the confidence intervals for δ CP . For the 2-dimensional confidence region in the ( δ CP , θ 23 ) plane the usual χ 2 approximation is better justified. The 2-dimensional region does not include the value δ CP = π/2 up to the 86.3% (89.2%) CL assuming a true normal (inverted) mass ordering. Furthermore, we study the sensitivity to δ CP and θ 23 of an increased exposure of the T2K experiment, roughly a factor 12 larger than the current exposure and including also anti-neutrino data. Also in this case deviations from Gaussianity may be significant, especially if the mass ordering is unknown
Surface and non-local effects for non-linear analysis of Timoshenko beams

In this paper, we present a non-local non-linear finite element formulation for the Timoshenko beam theory. The proposed formulation also takes into consideration the surface stress effects. Eringen׳s non-local differential model has been used to rewrite the non-local stress resultants in terms of non-local displacements. Geometric non-linearities are taken into account by using the Green–Lagrange strain tensor. A C0 beam element with three degrees of freedom has been developed. Numerical solutions are obtained by performing a non-linear analysis for bending and free vibration cases. Simply supported and clamped boundary conditions have been considered in the numerical examples. A parametric study has been performed to understand the effect of non-local parameter and surface stresses on deflection and vibration characteristics of the beam. The solutions are compared with the analytical solutions available in the literature. It has been shown that non-local effect does not exist in the nano-cantilever beam (Euler–Bernoulli beam) subjected to concentrated load at the end. However, there is a significant effect of non-local parameter on deflections for other load cases such as uniformly distributed load and sinusoidally distributed load (Cheng et al. (2015) [10]). In this work it has been shown that for a cantilever beam with concentrated load at free end, there is definitely a dependency on non-local parameter when Timoshenko beam theory is used. Also the effect of local and non-local boundary conditions has been demonstrated in this example. The example has also been worked out for other loading cases such as uniformly distributed force and sinusoidally varying force. The effect of the local or non-local boundary conditions on the end deflection in all these cases has also been brought out
Coalescing Cellular Automata

We say that a Cellular Automata (CA) is coalescing when its execution on two distinct (random) initial configurations in the same asynchronous mode (the same cells are updated in each configuration at each time step) makes both configurations become identical after a reasonable time. We prove coalescence for two elementary rules and show that there exists infinitely many coalescing CA. We then conduct an experimental study on all elementary CA and show that some rules exhibit a phase transition, which belongs to the universality class of directed percolation
In-plane mechanics of soft architectured fibre-reinforced silicone rubber membranes

International audienceSilicone rubber membranes reinforced with architectured fibre networks were processed with a dedicated apparatus, allowing a control of the fibre content and orientation. The membranes were subjected to tensile loadings combined with continuous and discrete kinematical field measurements (DIC and particle tracking). These tests show that the mechanical behaviour of the membranes is hyperelastic at the first order. They highlight the influence of the fibre content and orientation on both the membrane in-plane deformation and stress levels. They also prove that for the considered fibrous architectures and mechanical loadings, the motion and deformation of fibres is an affine function of the macroscale transformation. These trends are fairly well described by the micromechanical model proposed recently in Bailly et al. (JMBBM, 2012). This result proves that these materials are very good candidates for new biomimetic membranes, e.g. to improve aortic analogues used for in vitro experiments, or existing textiles used for vascular (endo)prostheses
Recording of fast activity at the onset of partial seizures: Depth EEG vs. scalp EEG.

International audienceRapid discharges (25-80Hz), a characteristic EEG pattern often recorded at seizure onset in partial epilepsies, are often considered as electrophysiological signatures of the epileptogenic zone. While the recording of rapid discharges from intracranial electrodes has long been established, their observation from the scalp is challenging. The prevailing view is that rapid discharges cannot be seen clearly (or at all) in scalp EEG because they have low signal-to-noise ratio. To date, however, no studies have investigated the 'observability' of rapid discharges, i.e. under what conditions and to what extent they can be visible in recorded EEG signals. Here, we used a model-based approach to examine the impact of several factors (distance to sources, skull conductivity, source area, source synchrony, and background activity) on the observability of rapid discharges in simultaneously simulated depth EEG and scalp EEG signals. In our simulations, the rapid discharge was clearly present in depth EEG signals but mostly almost not visible in scalp EEG signals. We identified some of the factors that may limit the observability of the rapid discharge on the scalp. Notably, surrounding background activity was found to be the most critical factor. The findings are discussed in relation to the presurgical evaluation of epilepsy
Propagation of Large Uncertainty Sets in Orbital Dynamics by Automatic Domain Splitting

Current approaches to uncertainty propagation in astrodynamics mainly refer to linearized models or Monte Carlo simulations. Naive linear methods fail in nonlinear dynamics, whereas Monte Carlo simulations tend to be computationally intensive. Differential algebra has already proven to be an efficient compromise by replacing thousands of pointwise integrations of Monte Carlo runs with the fast evaluation of the arbitrary order Taylor expansion of the flow of the dynamics. However, the current implementation of the DA-based high-order uncertainty propagator fails when the non-linearities of the dynamics prohibit good convergence of the Taylor expansion in one or more directions. We solve this issue by introducing automatic domain splitting. During propagation, the polynomial expansion of the current state is split into two polynomials whenever its truncation error reaches a predefined threshold. The resulting set of polynomials accurately tracks uncertainties, even in highly nonlinear dynamics. The method is tested on the propagation of (99942) Apophis post-encounter motion