pinecone/core-2020-05-10-deduplication huggingface dataset:
Innate immune humoral factors, C1q and factor H, with differential pattern recognition properties, alter macrophage response to carbon nanotubes

AbstractInteraction between the complement system and carbon nanotubes (CNTs) can modify their intended biomedical applications. Pristine and derivatised CNTs can activate complement primarily via the classical pathway which enhances uptake of CNTs and suppresses pro-inflammatory response by immune cells. Here, we report that the interaction of C1q, the classical pathway recognition molecule, with CNTs involves charge pattern and classical pathway activation that is partly inhibited by factor H, a complement regulator. C1q and its globular modules, but not factor H, enhanced uptake of CNTs by macrophages and modulated the pro-inflammatory immune response. Thus, soluble complement factors can interact differentially with CNTs and alter the immune response even without complement activation. Coating CNTs with recombinant C1q globular heads offers a novel way of controlling classical pathway activation in nanotherapeutics. Surprisingly, the globular heads also enhance clearance by phagocytes and down-regulate inflammation, suggesting unexpected complexity in receptor interaction.From the Clinical EditorCarbon nanotubes (CNTs) maybe useful in the clinical setting as targeting drug carriers. However, it is also well known that they can interact and activate the complement system, which may have a negative impact on the applicability of CNTs. In this study, the authors functionalized multi-walled CNT (MWNT), and investigated the interaction with the complement pathway. These studies are important so as to gain further understanding of the underlying mechanism in preparation for future use of CNTs in the clinical setting
Completion of G-spectra and stable maps between classifying spaces

AbstractWe prove structural theorems for computing the completion of a G-spectrum at the augmentation ideal of the Burnside ring of a finite group G. First we show that a G-spectrum can be replaced by a spectrum obtained by allowing only isotropy groups of prime power order without changing the homotopy type of the completion. We then show that this completion can be computed as a homotopy colimit of completions of spectra obtained by further restricting isotropy to one prime at a time, and that these completions can be computed in terms of completion at a prime.As an application, we show that the spectrum of stable maps from BG to the classifying space of a compact Lie group K splits non-equivariantly as a wedge sum of p-completed suspension spectra of classifying spaces of certain subquotients of G×K. In particular this describes the dual of BG
Surveillance of antimicrobial resistance in Lebanese hospitals: retrospective nationwide compiled data

SummaryAntimicrobial resistance is closely linked to antimicrobial use and is a growing concern worldwide. Antimicrobial resistance increases healthcare costs substantially in many countries, including Lebanon. National data from Lebanon have, in the most part, been limited to a few academic hospitals. The Lebanese Society of Infectious Diseases conducted a retrospective study to better describe the antimicrobial susceptibility patterns of bacterial isolates in Lebanon. Data were based on records retrieved from the bacteriology laboratories of 16 different Lebanese hospitals between January 2011 and December 2013. The susceptibility results of a total 20684 Gram-positive and 55594 Gram-negative bacteria were analyzed. The prevalence rate of methicillin-resistant Staphylococcus aureus was 27.6% and of vancomycin-resistant Enterococcus spp was 1%. Streptococcus pneumoniae had susceptibilities of 46% to oxacillin, 63% to erythromycin, and 98% to levofloxacin. Streptococcus pyogenes had susceptibilities of 94% to erythromycin and 95% to clindamycin. The mean ampicillin susceptibility of Haemophilus influenzae, Salmonella spp, and Shigella spp isolates was 79%, 81.3%, and 62.2%, respectively. The extended-spectrum beta-lactamase production rate for Escherichia coli was 32.3% and for Klebsiella spp was 29.2%. Acinetobacter spp showed high resistance to most antimicrobials, with low resistance to colistin (17.1%). Pseudomonas spp susceptibilities to piperacillin–tazobactam and imipenem were lower than 80% (79.7% and 72.8%, respectively). This study provides population-specific data that are valuable in guiding antimicrobial use in Lebanon and neighbouring countries and will help in the establishment of a surveillance system for antimicrobial resistance following the implementation of a nationwide standardization of laboratory methods and data entry
Planck 2015 results: III. LFI systematic uncertainties

We present the current accounting of systematic effect uncertainties for the Low Frequency Instrument (LFI) that are relevant to the 2015 release of the Planck cosmological results, showing the robustness and consistency of our data set, especially for polarization analysis. We use two complementary approaches: (i) simulations based on measured data and physical models of the known systematic effects; and (ii) analysis of difference maps containing the same sky signal ("null-maps"). The LFI temperature data are limited by instrumental noise. At large angular scales the systematic effects are below the cosmic microwave background (CMB) temperature power spectrum by several orders of magnitude. In polarization the systematic uncertainties are dominated by calibration uncertainties and compete with the CMB E-modes in the multipole range 10-20. Based on our model of all known systematic effects, we show that these effects introduce a slight bias of around 0.2σ on the reionization optical depth derived from the 70GHz EE spectrum using the 30 and 353GHz channels as foreground templates. At 30GHz the systematic effects are smaller than the Galactic foreground at all scales in temperature and polarization, which allows us to consider this channel as a reliable template of synchrotron emission. We assess the residual uncertainties due to LFI effects on CMB maps and power spectra after component separation and show that these effects are smaller than the CMB amplitude at all scales. We also assess the impact on non-Gaussianity studies and find it to be negligible. Some residuals still appear in null maps from particular sky survey pairs, particularly at 30 GHz, suggesting possible straylight contamination due to an imperfect knowledge of the beam far sidelobes
Measurement of the X(3872) production cross section via decays to J/ψπ+π− in pp collisions at √s = 7 TeV

The production of the X(3872) is studied in pp collisions at √s = 7TeV, using decays to J/ψπ+π−, where the J/ψ decays to two muons. The data were recorded by the CMS experiment and correspond to an integrated luminosity of 4.8fb−1. The measurements are performed in a kinematic range in which the X(3872) candidates have a transverse momentum 10 < pT < 50GeV and rapidity |y| < 1.2. The ratio of the X(3872) and ψ (2S) cross sections times their branching fractions into J/ψπ+π− is measured as a function of pT. In addition, the fraction of X(3872) originating from B decays is determined. From these measurements the prompt X(3872) differential cross section times branching fraction as a function of pT is extracted. The π+π− mass spectrum of the J/ψπ+π− system in the X(3872) decays is also investigated. © 2013, Springer Verlag. All rights reserved.The Scientific and Technical Research Council of Turkey, and Turkish Atomic Energy Authorit
Economic ordering and payment policies under progressive payment schemes and time-value of money

Trade credits have received considerable attention in recent years and have become one of the most important sources of short-term funding for many companies. The paper at hand studies the optimal ordering and payment policies of a buyer assuming that the supplier offers a progressive interest scheme. The contribution to the literature is twofold. First, the different financial conditions of the companies involved are taken into account by assuming that the credit interest rate of the buyer may, but not necessarily has to, exceed the interest rate charged by the supplier. In addition, the time-value of money is considered in this scenario which is relevant when trade credit terms are valid for a long period of time and payment flows need to be evaluated by their net present value to ensure long-term profitability. The models proposed enable decision makers to improve ordering and payment decisions and the results reveal that taking into account the temporal allocation of payments, the prevailing interest relation influences replenishment policies significantly
QCD corrections to longitudinal spin asymmetries in W±-boson production at RHIC

The polarized antiquark distributions in the proton can be measured by studying spin asymmetries in vector boson production in longitudinally polarized proton–proton collisions. The STAR and PHENIX experiments at BNL RHIC have reported first observations of single spin asymmetries in W± production most recently. We compute the QCD corrections to single and double spin asymmetries, taking account of the leptonic decay of the W± boson and of restrictions on the kinematical acceptance of the detectors. The QCD corrections have only a small impact on the asymmetries, such that a reliable extraction of the polarized antiquark distributions can be envisaged once more precise measurements are made
Functional approaches to lifespan development - Editorial

Most of lifespan research focuses on age-related changes and plasticity as early markers of decline or performance improve- ments achieved through training interventions. This special issue on functional approaches to lifespan development focuses on age-related stabilization in complex functions such as cognitive and motor performance and well-being on the levels of brain and behavior. One central question focuses on what elements have to change for individually important outcomes to remain stable in old age, putting the many experimental studies on the plasticity of elementary processes in the context of the recognition that aging individuals most often successfully manage their development and maintain high levels of functioning. Aging research will profit from understanding the processes and potentials of lifespan developmental stabilization
Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones

The conditions that permit the interaction of immediate-early proteins of murine cytornegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the regulatory major immediate-early protein, interacts with DNA and dissociates at salt concentrations between 0.3 and 0.6 M NaCl. pp76, a cleavage product of pp89, and additional minor ie1 proteins eluted already at low ionic strength. Cellular DNA-binding factors were required for association of pp89 with DNA. These factors were identified as core histones. Chromatography of IE proteins on histone-Sepharose in the absence of DNA revealed a high-binding affinity that was resistant to 2 M NaCl. These results suggest that pp89 has no direct DNA-binding activity. A role for an amino acid sequence homology in the N-terminal region of pp89 with histone H2B in the pp89-histone-DNA Interaction is discussed.
Eleven-dimensional origin of string/string duality: a one-loop test

Membrane/ fivebrane duality in D = 11 implies Type IIA string/Type IIA fivebrane duality in D = 10, which in turn implies Type HA string/heterotic string duality in D = 6. To test the conjecture, we reproduce the corrections to the 3-form field equations of the D = 10 Type IIA string (a mixture of tree-level and one-loop effects) starting from the Chern-Simons corrections to the 7-form Bianchi identities of the D = 11 fivebrane (a purely tree-level effect). K3 compactification of the latter then yields the familiar gauge and Lorentz Chem-Simons corrections to 3-form Bianchi identities of the heterotic string. We note that the absence of a dilaton in the D = 11 theory allows us to fix both the gravitational constant and the fivebrane tension in terms of the membrane tension. We also comment on an apparent conflict between fundamental and solitonic heterotic strings and on the puzzle of a fivebrane origin of S-duality
Search for new physics in the monophoton final state in proton-proton collisions at $\sqrt{s}$ = 13 TeV

A search is conducted for new physics in a final state containing a photon and missing transverse momentum in proton-proton collisions at $\sqrt{s}$ = 13 TeV. The data collected by the CMS experiment at the CERN LHC correspond to an integrated luminosity of 12.9 $fb^{−1}$. No deviations are observed relative to the predictions of the standard model. The results are interpreted as exclusion limits on the dark matter production cross sections and parameters in models containing extra spatial dimensions. Improved limits are set with respect to previous searches using the monophoton final state. In particular, the limits on the extra dimension model parameters are the most stringent to date in this channel
Search for supersymmetry in events with at least one photon, missing transverse momentum, and large transverse event activity in proton-proton collisions at √s = 13 TeV

A search for physics beyond the standard model in final states with at least one photon, large transverse momentum imbalance, and large total transverse event activity is presented. Such topologies can be produced in gauge-mediated supersymmetry models in which pair-produced gluinos or squarks decay to photons and gravitinos via short-lived neutralinos. The data sample corresponds to an integrated luminosity of 35.9 fb[superscript −1] of proton-proton collisions at s√=13 TeV recorded by the CMS experiment at the LHC in 2016. No significant excess of events above the expected standard model background is observed. The data are interpreted in simplified models of gluino and squark pair production, in which gluinos or squarks decay via neutralinos to photons. Gluino masses of up to 1.50-2.00 TeV and squark masses up to 1.30-1.65 TeV are excluded at 95% confidence level, depending on the neutralino mass and branching fraction. Keywords: Hadron-Hadron scattering (experiments); Supersymmetry; Photon productio
The H I supershell GS 118+01-44 and its role in the interstellar medium

Aims. We carry out a multiwavelength study to characterize the H i  supershell designated GS 118+01−44, and to analyse its possible origin. Methods. A multiwavelength study has been carried out to study the supershell and its environs. We performed an analysis of the H i, CO, radio continuum, and infrared emission distributions. Results. The Canadian Galactic Plane Survey (CGPS) H i  data reveals that GS 118+01−44  is centred at (l,b) = (117°̣7, 1°̣4) with a systemic velocity of −44.3 km s-1. According to Galactic rotation models this structure is located at 3.0 ± 0.6 kpc from the Sun. There are several H ii  regions and three supernova remnants (SNRs) catalogued in the region. On the other hand, the analysis of the temperature spectral index distribution shows that in the region there is a predominance of non-thermal emission. Infrared emission shows that cool temperatures dominate the area of the supershell. Concerning the origin of the structure, we found that even though several OB stars belonging to Cas OB5 are located in the interior of GS 118+01−44, an analysis of the energy injected by these stars through their stellar winds indicates that they do not have sufficient energy to create GS 118+01−44. Therefore, an additional energy source is needed to explain the genesis of GS 118+01−44. On the other hand, the presence of several H ii  regions and young stellar object candidates in the edges of GS 118+01−44  shows that the region is still active in forming new stars.Fil: Suad, Laura Andrea. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomia; ArgentinaFil: Cichowolski, Silvina. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Noriega Crespo, A.. Space Telescope Science Institute; Estados UnidosFil: Arnal, Edmundo Marcelo. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomia; ArgentinaFil: Testori, Juan Carlos. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomia; ArgentinaFil: Flagey, N.. Space Telescope Science Institute; Estados Unido
Corrections and new developments in rigid earth nutation theory - III. Final tables "REN-2000" including crossed-nutation and spin-orbit coupling effects

We present here the new tables REN-2000 of the nutation for a rigid Earth model, starting from Hamiltonian theory, with a level of truncature at 0.1 mu as for individual coefficients instead of 5 mu as (Kinoshita & Souchay 1990). For this presentation to be achieved we first carry out the calculations of the second-order effects due to crossed-nutations and spin-orbit coupling, at the same level of truncation as above. This paper is the third and last one in the frame of the complete reconstruction of the theory of the rigid Earth nutation. It is the complementary part to previous studies concerning the luni-solar nutation involving indirect planetary effects (Souchay & Kinoshita 1996), and the influence of the second-order geopotential (J(3), J(4)) and of the direct planetary effect (Souchay & Kinoshita 1997). Quasi-diurnal and sub-diurnal nutations coming from the harmonics of degree 2, 3 and 4 of the geopotential are also included in REN-2000, their values being taken from Folgueira et al. (1998a,b). A presentation of the series REN-2000 is done at the end of the paper, with separated informations for each contribution
FCNC and CP Violation Observables in a SU(3)-flavoured MSSM

A non-Abelian flavour symmetry in a minimal supersymmetric standard model can
explain the flavour structures in the Yukawa couplings and simultaneously solve
the SUSY flavour problem. Similarly the SUSY CP problem can be solved if CP is
spontaneously broken in the flavour sector. In this work, we present an
explicit example of these statements with a SU(3) flavour symmetry and
spontaneous CP violation. In addition, we show that it is still possible to
find some significant deviation from the SM expectations as far as FCNC and CP
violation are concerned. We find that large contributions can be expected in
lepton flavour violating decays, as $\mu \to e \gamma$ and $\tau \to \mu
\gamma$, electric dipole moments, $d_e$ and $d_n$ and kaon CP violating
processes as $\epsilon_K$. Thus, these flavoured MSSM realizations are
phenomenologically sensitive to the experimental searches in the realm of
flavor and CP vioation physics.Comment: 56 pages, 12 figures; included new NLO contributions to nEDM from
  charged Higgs, relevant figures updated, and analysis of O(1) coefficients;
  added appendices and reference
PageRank Optimization by Edge Selection

The importance of a node in a directed graph can be measured by its PageRank.
The PageRank of a node is used in a number of application contexts - including
ranking websites - and can be interpreted as the average portion of time spent
at the node by an infinite random walk. We consider the problem of maximizing
the PageRank of a node by selecting some of the edges from a set of edges that
are under our control. By applying results from Markov decision theory, we show
that an optimal solution to this problem can be found in polynomial time. Our
core solution results in a linear programming formulation, but we also provide
an alternative greedy algorithm, a variant of policy iteration, which runs in
polynomial time, as well. Finally, we show that, under the slight modification
for which we are given mutually exclusive pairs of edges, the problem of
PageRank optimization becomes NP-hard.Comment: 30 pages, 3 figure
Measurement of the D* Meson Production Cross Section and F_2^{ccbar}, at
  High Q^2, in ep Scattering at HERA

The inclusive production of D*(2010) mesons in deep-inelastic ep scattering
is measured in the kinematic region of photon virtuality 100 < Q^2 < 1000 GeV^2
and inelasticity 0.02 < y < 0.7. Single and double differential cross sections
for inclusive D* meson production are measured in the visible range defined by
|eta(D*)| < 1.5 and p_T(D*) > 1.5 GeV. The data were collected by the H1
experiment during the period from 2004 to 2007 and correspond to an integrated
luminosity of 351 pb^{-1}. The charm contribution, F_2^{ccbar}, to the proton
structure function F_2 is determined. The measurements are compared with QCD
predictions.Comment: 22 pages, 5 figure
A measurement of the transverse velocity of Q2237+0305

Determination of microlensing parameters in the gravitationally lensed quasar
Q2237+0305 from the statistics of high magnification events will require
monitoring for more than 100 years (Wambsganss, Paczynski & Schneider 1990).
However we show that the effective transverse velocity of the lensing galaxy
can be determined on a more realistic time-scale through consideration of the
distribution of light-curve derivatives. The 10 years of existing monitoring
data for Q2237+0305 are analysed. These data display strong evidence for
microlensing that is not associated with a high magnification event. An upper
limit of v < 500 km/sec is obtained for the galactic transverse velocity which
is smaller than previously assumed values. The analysis suggests that the
observed microlensing variation may be predominantly due to stellar proper
motions. The statistical significance of the results obtained from our method
will be increased by the addition of data points from current and future
monitoring campaigns. However reduced photometric errors will be more valuable
than an increased sampling rate.Comment: 16 pages, including 17 figures. Accepted for publication in M.N.R.A.
Structure, phase behavior and inhomogeneous fluid properties of binary
  dendrimer mixtures

The effective pair potentials between different kinds of dendrimers in
solution can be well approximated by appropriate Gaussian functions. We find
that in binary dendrimer mixtures the range and strength of the effective
interactions depend strongly upon the specific dendrimer architecture. We
consider two different types of dendrimer mixtures, employing the Gaussian
effective pair potentials, to determine the bulk fluid structure and phase
behavior. Using a simple mean field density functional theory (DFT) we find
good agreement between theory and simulation results for the bulk fluid
structure. Depending on the mixture, we find bulk fluid-fluid phase separation
(macro-phase separation) or micro-phase separation, i.e., a transition to a
state characterized by undamped periodic concentration fluctuations. We also
determine the inhomogeneous fluid structure for confinement in spherical
cavities. Again, we find good agreement between the DFT and simulation results.
For the dendrimer mixture exhibiting micro-phase separation, we observe rather
striking pattern formation under confinement.Comment: 8 pages, 10 figure