pinecone/core-2020-05-10-deduplication huggingface dataset:
Coupling Interval Variability Differentiates Ventricular Ectopic Complexes Arising in the Aortic Sinus of Valsalva and Great Cardiac Vein From Other Sources

Objectives
The objective of this study was to determine whether premature ventricular contractions (PVCs) arising from the aortic sinuses of Valsalva (SOV) and great cardiac vein (GCV) have coupling interval (CI) characteristics that differentiate them from other ectopic foci.

Background
PVCs occur at relatively fixed CI from the preceding normal QRS complex in most patients. However, we observed patients with PVCs originating in unusual areas (SOV and GCV) in whom the PVC CI was highly variable. We hypothesized that PVCs from these areas occur seemingly randomly because of the lack of electrotonic effects of the surrounding myocardium.

Methods
Seventy-three consecutive patients referred for PVC ablation were assessed. Twelve consecutive PVC CIs were recorded. The ΔCI (maximum – minimum CI) was measured.

Results
We studied 73 patients (age 50 ± 16 years, 47% male). The PVC origin was right ventricular (RV) in 29 (40%), left ventricular (LV) in 17 (23%), SOV in 21 (29%), and GCV in 6 (8%). There was a significant difference between the mean ΔCI of RV/LV PVCs compared with SOV/GCV PVCs (33 ± 15 ms vs. 116 ± 52 ms, p < 0.0001). A ΔCI of >60 ms demonstrated a sensitivity of 89%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 94%. Cardiac events were more common in the SOV/GCV group versus the RV/LV group (7 of 27 [26%] vs. 2 of 46 [4%], p < 0.02).

Conclusions
ΔCI is more pronounced in PVCs originating from the SOV or GCV. A ΔCI of 60 ms helps discriminate the origin of PVCs before diagnostic electrophysiological study and may be associated with increased frequency of cardiac events
High temperature structural and magnetic properties of cobalt nanorods

International audienceWe present in this paper the structural and magnetic properties of high aspect ratio Co nanoparticles (~10) at high temperatures (up to 623 K) using in-situ X ray diffraction (XRD) and SQUID characterizations. We show that the anisotropic shapes, the structural and texture properties are preserved up to 500 K. The coercivity can be modelled by µ0HC = 2(KMC + Kshape)/MS with KMC the magnetocrystalline anisotropy constant, Kshape the shape anisotropy constant and MS the saturation magnetization. HC decreases linearly when the temperature is increased due to the loss of the Co magnetocrystalline anisotropy contribution. At 500K, 50% of the room temperature coercivity is preserved corresponding to the shape anisotropy contribution only. We show that the coercivity drop is reversible in the range 300 - 500 K in good agreement with the absence of particle alteration. Above 525 K, the magnetic properties are irreversibly altered either by sintering or by oxidation
Horizontal rotation signals detected by "G-Pisa" ring laser for the
  Mw=9.0, March 2011, Japan earthquake

We report the observation of the ground rotation induced by the Mw=9.0, 11th
of March 2011, Japan earthquake. The rotation measurements have been conducted
with a ring laser gyroscope operating in a vertical plane, thus detecting
rotations around the horizontal axis. Comparison of ground rotations with
vertical accelerations from a co-located force-balance accelerometer shows
excellent ring laser coupling at periods longer than 100s. Under the plane wave
assumption, we derive a theoretical relationship between horizontal rotation
and vertical acceleration for Rayleigh waves. Due to the oblique mounting of
the gyroscope with respect to the wave direction-of-arrival, apparent
velocities derived from the acceleration / rotation rate ratio are expected to
be always larger than, or equal to the true wave propagation velocity. This
hypothesis is confirmed through comparison with fundamental-mode, Rayleigh wave
phase velocities predicted for a standard Earth model.Comment: Accepted for publication in Journal of Seismolog
Transient energy growth for the Lamb–Oseen vortex

The transient evolution of infinitesimal disturbances which optimally induce algebraic growth in the Lamb-Oseen (gaussian) vortex is studied using a direct-adjoint technique. This optimal perturbation analysis reveals that the Lamb-Oseen vortex allows for intense amplification of kinetic energy for 2D and 3D perturbations of azimuthal wavenumber m = 1. In both cases, the disturbances experiencing the most growth initially take the form of concentrated spirals at the outer periphery of the vortex which rapidly excite bending waves within the vortex core. In the limit of large wavelengths, the optimal perturbation leads to arbitrarily large growths via an original scenario combining the Orr mechanism with vortex induction
The exposure of the hybrid detector of the Pierre Auger Observatory

International audienceThe Pierre Auger Observatory is a detector for ultra-high energy cosmic rays. It consists of a surface array to measure secondary particles at ground level and a fluorescence detector to measure the development of air showers in the atmosphere above the array. The "hybrid" detection mode combines the information from the two subsystems. We describe the determination of the hybrid exposure for events observed by the fluorescence telescopes in coincidence with at least one water-Cherenkov detector of the surface array. A detailed knowledge of the time dependence of the detection operations is crucial for an accurate evaluation of the exposure. We discuss the relevance of monitoring data collected during operations, such as the status of the fluorescence detector, background light and atmospheric conditions, that are used in both simulation and reconstruction
MOMP from Campylobacter jejuni Is a Trimer of 18-Stranded β-Barrel Monomers with a Ca(2+) Ion Bound at the Constriction Zone

The Gram-negative organism Campylobacter jejuni is the major cause of food poisoning. Unlike Escherichia coli, which has two major porins, OmpC and OmpF, C. jejuni has one, termed major outer membrane protein (MOMP) through which nutrients and antibiotics transit. We report the 2.1-Å crystal structure of C. jejuni MOMP expressed in E. coli and a lower resolution but otherwise identical structure purified directly from C. jejuni. The 2.1-Å resolution structure of recombinant MOMP showed that although the protein has timeric arrangement similar to OmpC, it is an 18-stranded, not 16-stranded, β-barrel. The structure has identified a Ca 2 + bound at the constriction zone, which is functionally significant as suggested by molecular dynamics and single-channel experiments. The water-filled channel of MOMP has a narrow constriction zone, and single- molecule studies show a monomeric conductivity of 0.7 ± 0.2 nS and a trimeric conductance of 2.2 ± 0.2 nS. The ion neutralizes negative charges at the constriction zone, reducing the transverse electric field and reversing ion selectivity. Modeling of the transit of ciprofloxacin, an antibiotic of choice for treating Campylobacter infection, through the pore of MOMP reveals a trajectory that is dependent upon the presence metal ion
Two-loop QCD corrections to massless quark-gluon scattering.

We present the  virtual QCD corrections to the scattering process of massless quark  due to the interference of tree and two-loop amplitudes and to the self-interference of one-loop amplitudes. We work in conventional dimensional regularisation and our results are renormalised in the  scheme. The structure of the infrared divergences agrees with that predicted by Catani while expressions for the finite remainder are given for the  and the qg→qg () scattering processes in terms of logarithms and polylogarithms that are real in the physical region. These results, together with those previously obtained for quark–quark scattering, are important ingredients in the next-to-next-to-leading order contribution to inclusive jet production at hadron colliders. \ud
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Health trends of the ageing population in Sweden : association of mortality reductions with morbidity and quality of life improvements

Since the beginning of the 19th century, and particularly after the 1950s, life expectancy of the
elderly in all developed countries, including Sweden, has increased substantially, posing the
question whether the health of the ageing population has also been improving over time. The
aim of this PhD thesis was to investigate morbidity occurrence among the elderly in Sweden,
attempting to answer the question of whether their overall health and quality of life has been
improving over time in parallel with mortality reductions. Analysis was conducted using data
from the national registers (studies I to III), combined in study IV with data from the Stockholm
Public Health Cohort.




In Studies I and II, the time from age 60 until the first and subsequent morbidity, measured using
hospital admissions of any cause as a proxy, was estimated for the years between 1995 and
2010; it was then associated with the change over time in the remaining life expectancy at the
age of 60. Postponement to higher ages for both mortality and first and subsequent morbidity
was observed, for both men and women, and for most ages.




In Study III, morbidity from hip fractures, which is a prominent disease among the elderly in
Sweden, has been estimated. In addition, survival after the disease and the lifetime risk of the
disease, have been measured. Incidence of hip fractures decreased over time for both men and
women up to the age of 94, while no real improvements have been observed for survival after
the first hip fracture or for the lifetime risk.




In addition to administrative information from registers about hospital admissions, which does
not necessarily capture individuals’ full disease panorama, the health-related quality of life
(HRQoL) of individuals was used in study IV to determine whether a hospitalization could
indicate the onset of a period of life for the elderly lived with compromised health. Results
revealed that only one hospitalization had no long-term consequences on the quality of life;
multiple ones, however, did lead to severe morbidity and quality of life reductions.




To conclude, morbidity among the elderly in Sweden seems to have been postponed to higher
ages over the years, in parallel with survival improvements observed during the same period.
However, individuals have not become more fragile, since the occurrence of subsequent
morbidity events has also been prolonged. Lifestyle changes and the increasingly beneficial role
preventive medicine plays for individuals’ health, which could be leading to the reduction of the
incidence of prominent diseases for the elderly such as cardiovascular conditions and hip
fractures, could explain such health improvements over time
Evaluation of Phyllanthus polyphyllus L. Extract and its Active Constituent as a Source of Antifungal, Anti-Aflatoxigenic, and Antioxidant Activities

The present investigation was carried out to evaluate the antifungal activities of Phyllanthus polyphyllus L. leaf extract, to isolate its active constituent 4-o-methyl gallic acid (4-o-MGA), and to determine the antioxidant and antiaflatoxigenic properties. The bioassay-guided fractionation of methanol extract led to the isolation of active compound 4-o-methylgallic acid. The methanol extract showed the highest amount of phenolic content (290 mg GAE/g dry extract), which indicated the involvement of phenolic compounds in the radical scavenging activity observed by the methanol extract. The antioxidant capacity of 4-o-MGA was greater than the standard butylated hydroxytoluene, followed by methanol extract. The concentration-dependent growth inhibitory activity was observed against the tested fungi, in which the field fungi were susceptible, while the storage fungi were found to be more resistant including aflatoxigenic A. flavus. A correlation was observed between fungal biomass and aflatoxin production in control and treatment, there was a decrease in biomass of A. flavus and aflatoxin production with increasing concentration. The aflatoxin production was completely inhibited in vitro by methanol extract at 1 mg/mL and 4-o-MGA at 2 mg/mL, but the mycelial growth was not inhibited completely. The inhibition of aflatoxin production was relatively higher than the mycelial growth inhibition of A. flavus, such behaviors might have been determined by the presence of hydrolysable tannin 4-o-MGA in the extract, which is known to inhibit the aflatoxin biosynthesis. The significant antioxidant and aflatoxin inhibitory activities of P. polyphyllus could be exploited for its application in preventing oxidative deterioration and fungal spoilage of food product
Zeolite-Y encapsulated VO[2-(2′hydroxyphenyl)benzimidazole] complex: investigation of its catalytic activity towards oxidation of organic substrates

Zeolite-Y encapsulated VO(IV)2-(2′-hydroxyphenyl)benzimidazole (ohpbmzl) was synthesized by flexible ligand approach and characterized using various physico-chemical techniques such as elemental analysis, XRD, inductively coupled plasma-atomic emission, fourier transform infrared spectroscopy, UV–vis-diffuse reflectance and electron paramagnetic resonance spectroscopy, thermogravimetric analysis, BET surface area and cyclic voltammetry (CV). Based on the results a square pyramidal structure was suggested for the encapsulated complex. Shift in UV absorbance to higher wavelength and variations in the redox potential values compared to the non-encapsulated complex in CV confirmed the successful encapsulation of the complex in the zeolite matrix. The catalytic efficacy was investigated towards oxidation of phenol, styrene, cyclohexane and ethyl benzene in acetonitrile using H2O2 as oxidant. Influence of reaction parameters like catalyst and substrate concentration, substrate/H2O2 molar ratio, and temperature were investigated to optimize the reaction conditions for maximum substrate conversion and selectivity towards desired products using the encapsulated complex. The catalytic activity was compared with vanadyl exchanged zeolite-Y (VO-Y) and non-encapsulated complex. The encapsulated complex retained its stability up to 3 runs as confirmed by recycling studies. Mechanistic pathways were proposed for all the probe reactions
Top-quark loop corrections in Z+jet and Z+2 jet production

The sophistication of current predictions for $Z+$jet production at hadron
colliders necessitates a re-evaluation of any approximations inherent in the
theoretical calculations. In this paper we address one such issue, the
inclusion of mass effects in top-quark loops. We ameliorate an existing
calculation of $Z+1$~jet and $Z+2$~jet production by presenting exact analytic
formulae for amplitudes containing top-quark loops that enter at
next-to-leading order in QCD. Although approximations based on an expansion in
powers of $1/m_t^2$ can lead to poor high-energy behavior, an exact treatment
of top-quark loops demonstrates that their effect is small and has limited
phenomenological interest.Comment: 33 pages, 9 figure
Roth's solvability criteria for the matrix equations ${AX-\widehat
  XB=C}$ and ${X-A\widehat{X}B=C}$ over the skew field of quaternions with an
  involutive automorphism $q\mapsto \hat q$

The matrix equation $AX-XB=C$ has a solution if and only if the matrices
[A&C\\0&B] and [A &0\\0 & B] are similar. This criterion was proved over a
field by W.E. Roth (1952) and over the skew field of quaternions by Huang
Liping (1996). H.K. Wimmer (1988) obtained an analogous criterion for the
matrix equation $X-AXB=C$ over a field. We extend these criteria to the matrix
equations $AX-\widehat XB=C$ and $X-A\widehat XB=C$ over the skew field of
quaternions with a fixed involutive automorphism $q\mapsto \hat q$.Comment: 14 page
On a class of integrable systems of Monge-Amp\`ere type

We investigate a class of multi-dimensional two-component systems of
Monge-Amp\`ere type that can be viewed as generalisations of heavenly-type
equations appearing in self-dual Ricci-flat geometry. Based on the
Jordan-Kronecker theory of skew-symmetric matrix pencils, a classification of
normal forms of such systems is obtained. All two-component systems of
Monge-Amp\`ere type turn out to be integrable, and can be represented as the
commutativity conditions of parameter-dependent vector fields. Geometrically,
systems of Monge-Amp\`ere type are associated with linear sections of the
Grassmannians. This leads to an invariant differential-geometric
characterisation of the Monge-Amp\`ere property.Comment: arXiv admin note: text overlap with arXiv:1503.0227
Assessing Asthma Symptoms in Adolescents and Adults : Qualitative Research Supporting Development of the Asthma Daily Symptom Diary

We thank the members of the US Food and Drug Administration’s Qualification Review Team for their feedback during the development of the ADSD. Source of financial support: Funding for this research was provided by the following PRO Consortium member firms: Actelion; Amgen; AstraZeneca; Boehringer-Ingelheim; Forest Laboratories; Genentech; GlaxoSmithKline; Ironwood Pharmaceuticals; Janssen, Merck, Sharp & Dohme Corp.; Novartis; Pfizer; and Sanofi. In addition, Critical-Path Institute’s PRO Consortium is supported by Critical-Path Public-Private Partnerships (grant no. 1U18FD005320) from the US Food and Drug Administration.Peer reviewedPublisher PD
Evaluation of growth methods for the heteroepitaxy of non-polar (11-20) GaN on sapphire by MOVPE

Non-polar a-plane gallium nitride (GaN)  lms have been grown on r-plane (1102) sapphire by metal organic vapour
phase epitaxy (MOVPE). A total of  ve in-situ defect reduction techniques for a-plane GaN are compared, including
two variants with a low temperature GaN nucleation layer (LTNL) and three variants without LTNL, in which the high-
temperature growth of GaN is performed directly on the sapphire using various crystallite sizes. The material quality is
investigated by photoluminescence (PL), x-ray di raction, cathodoluminescence, atomic force and optical microscopy. It
is found that all layers are anisotropically strained with threading dislocation densities over 109 cm2. The PL spectrum
is typically dominated by emission from basal plane stacking faults. Overall, growth techniques without LTNL do not
yield any particular improvement and even result in the creation of new defects, ie. inversion domains, which are seldom
observed if a low temperature GaN nucleation layer is used. The best growth method uses a LTNL combined with a
single silicon nitride interlayer.This work is supported by the Engineering and Physical Sciences Research Council (United Kingdom) under EP/J003603/1 and EP/H0495331. The European Research Council has also provided  nancial support under the European Community's Seventh Framework Programme (FP7/2007-2013) / ERC grant agreement no 279361 (MACONS).This is the final published version, also available from Elsevier at: http://dx.doi.org/10.1016/j.jcrysgro.2014.09.00
Delineating the biosynthesis of gentamicin X2, the common precursor of the gentamicin C antibiotic complex.

Gentamicin C complex is a mixture of aminoglycoside
antibiotics used worldwide to treat severe Gramnegative
bacterial infections. Despite its clinical
importance, the enzymology of its biosynthetic
pathway has remained obscure. We report here
insights into the four enzyme-catalyzed steps that
lead from the first-formed pseudotrisaccharide gentamicin
A2 to gentamicin X2, the last common intermediate
for all components of the C complex. We have
used both targeted mutations of individual genes
and reconstitution of portions of the pathway in vitro
to show that the secondary alcohol function at C-3"
of A2 is first converted to an amine, catalyzed by the
tandem operation of oxidoreductase GenD2 and
transaminase GenS2. The amine is then specifically
methylated by the S-adenosyl-L-methionine (SAM)-
dependent N-methyltransferase GenN to form gentamicin
A. Finally, C-methylation at C-4" to form
gentamicin X2 is catalyzed by the radical SAM-dependent
and cobalamin-dependent enzyme GenD1.This work was supported by a project grant from the Medical Research
Council, UK (G1001687) to P.F.L.; and by the 973 and 863 programs from
the Ministry of Science and Technology of China, National Science Foundation
of China, and the Translational Medical Research Fund of Wuhan University
School of Medicine to Y.S.; E.M. thanks the Gates Cambridge Trust for a
scholarship. We also gratefully acknowledge Dr. Xinzhou Yang, SouthCentral
University for Nationalities, for his assistance in separation of gentamicin
A2. We thank Dr. Andrew Truman (John Innes Institute) for helpful
discussions.This is the final published version. It was originally published in Chemistry and Biology, Volume 22, Issue 2, 19 February 2015, Pages 251–261, doi:10.1016/j.chembiol.2014.12.01
Prospective associations between sedentary time, sleep duration and adiposity in adolescents

Objective

The objective of this study was to investigate whether objectively measured sedentary time and sleep duration are associated with changes in adiposity from mid- to late adolescence.
Methods

Students (n = 504, 42% boys) were recruited from schools in Cambridgeshire, UK. At baseline (mean age 15.0 ± 0.3 years), sedentary time was objectively measured by ≥3 days of combined heart rate and movement sensing. Concurrently, sleep duration was measured by combined sensing in conjunction with self-reported bed times. Fat mass index (FMI; kg/m2) was estimated at baseline and follow-up (17.5 ± 0.3 years) by anthropometry and bioelectrical impedance. FMI change (ΔFMI) was calculated by subtracting the baseline from follow-up values. Linear regression models adjusted for basic demographics, moderate-to-vigorous physical activity (MVPA), and depressive symptoms were used to investigate associations of sedentary time and sleep duration (mutually adjusted for one another) with ΔFMI.
Results

FMI increased by 0.5 and 0.6 kg/m2 in boys and girls, respectively, but there was no association between sedentary time and ΔFMI in either gender (p ≥ 0.087), and no association between sleep duration and ΔFMI in girls (p ≥ 0.61). In boys, each additional hour of baseline sleep significantly reduced the ΔFMI by 0.13 kg/m2 (p = 0.049), but there was little evidence for this association after adjusting for MVPA and depressive symptoms (p = 0.15).
Conclusions

Sedentary time may not determine changes in adiposity from mid- to late adolescence, nor may sleep duration in girls. However, sleep length may be inversely associated with adiposity gain in boys, depending on whether the relationship is confounded or mediated by MVPA and depression.This work was supported by the Medical Research Council (Unit Programme number MC_UU_12015/3), the Wellcome Trust (grant 074296/Z/04/Z) and the British Heart Foundation (grant FS/12/58/29709 to KW).This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.sleep.2015.02.53
Search for direct slepton and gaugino production in final states with two leptons and missing transverse momentum with the ATLAS detector in pp collisions at √s = 7 TeV

A search for the electroweak pair production of charged sleptons and weak gauginos decaying into final states with two leptons is performed using 4.7 fb[superscript −1] of proton–proton collision data at √s = 7 TeV recorded with the ATLAS experiment at the Large Hadron Collider. No significant excesses are observed with respect to the prediction from Standard Model processes. In the scenario of direct slepton production, if the sleptons decay directly into the lightest neutralino, left-handed slepton masses between 85 and 195 GeV are excluded at 95% confidence level for a 20 GeV neutralino. Chargino masses between 110 and 340 GeV are excluded in the scenario of direct production of wino-like chargino pairs decaying into the lightest neutralino via an intermediate on-shell charged slepton for a 10 GeV neutralino. The results are also interpreted in the framework of the phenomenological minimal supersymmetric Standard Model.United States. Dept. of EnergyNational Science Foundation (U.S.)Brookhaven National Laborator