pinecone/core-2020-05-10-deduplication huggingface dataset:
Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria

Unobstructed vision requires a particular refractive index of the lens, a measure based on the organization of the structural proteins within the differentiated lens cells. To ensure an intact lens structure, homeostasis within the lens cells is indispensable. Alterations of the lens structure result in opacity and lead to cataract. Renal glucosuria is defined by elevated glucose level in the urine without hyperglycemia and without evidence of morphological renal anomalies. In a Swiss family with autosomal dominant juvenile cataract, microcornea, and renal glucosuria, we have identified a nonsense mutation in a member of the carboxylic acid transporter family SLC16. The underlying gene defect in SLC16A12 resides within a 3 cM region on chromosome 10q23.13 defined by linkage mapping of this phenotype. We found tissue-specific variability of SLC16A12 transcript levels in control samples, with high expression in the eye and kidney, the two organs affected by this syndrome. This report demonstrates biological relevance of this solute carrier. We hypothesize that SLC16A12 is important for lens and kidney homeostasis and discuss its potential role in age-related cataract
Polarization control in two-color above-threshold ionization of atomic helium

Two-color multiphoton ionization of atomic helium was investigated by combining extreme ultraviolet (XUV) radiation from the Free Electron Laser in Hamburg with an intense synchronized optical laser. In the photoelectron spectrum, lines associated with direct ionization and above-threshold ionization show strong variations of their amplitudes as a function of both the intensity of the optical dressing field and the relative orientation of the linear polarization vectors of the two fields. The polarization dependence provides direct insight into the symmetry of the outgoing electrons in above-threshold ionization. In the high field regime, the monochromaticity of the XUV radiation enables the unperturbed observation of nonlinear processes in the optical field
Optimisation of the enzyme-linked lectin assay for enhanced glycoprotein and glycoconjugate analysis

Lectin’s are proteins capable of recognising and binding to specific oligosaccharide tructures found on glycoproteins and other biomoloecules. As such they have found tility for glycoanalytical applications. One common difficulty encountered in the pplication of these proteins, particularly in multi-well plate assay formats known as Enzyme Linked Lectin Assays (ELLA’s), is in finding appropriate blocking solutions to prevent non-specific binding with plate surfaces. Many commonly used blocking agents contain carbohydrates and generate significant background signals in ELLA’s, limiting the utility of the assay.\ud
\ud
In this study we examined the suitability of a range of blocking reagents, including rotein based, synthetic and commercially available carbohydrate free blocking eagents, for ELLA applications. Each blocking reagent was assessed against a panel f 19 commercially available biotinylated lectins exhibiting diverse structures and arbohydrate specificities. We identified the synthetic polymer Polyvinyl Alcohol PVA) as the best global blocking agent for performing ELLA’s. We ultimately present n ELLA methodology facilitating broad spectrum lectin analysis of glycoconjugates nd extending the utility of the ELLA
Vertical composition fluctuations in (Ga,In)(N,As) quantum wells grown on vicinal (1 1 1) B GaAs

In this work, we present a detailed transmission electron microscopy analysis of the interfacial structure and composition uniformity of (Ga,In)(N,As) quantum wells grown by molecular beam epitaxy on vicinal GaAs(1 1 1)B substrates. Vertical composition fluctuations inside the (Ga,In)(N,As) quantum well are detected depending on the growth conditions, in particular the V/III flux ratio and the growth rate. This vertical composition fluctuation due to the phase separation tendency is in contrast to the (0 0 1) case, where the fluctuations proceed in the lateral direction. The specific character of the phase instabilities is discussed with respect to the spinodal decomposition of the (Ga,In)(N,As) alloy grown by step-flow on the misoriented (1 1 1)B substrates. The vertical composition fluctuations are explained by the formation of step bunches of alternating composition as a consequence of the different propagation velocity of steps with different atom terminations
Three-dimensional streaming flows driven by oscillatory boundary layers

Three-dimensional (3D) oscillatory boundary layers attached to deformable solid walls and free boundaries of general form are analyzed via matched asymptotic expansions, to obtain the time-averaged tangential velocities and tangential stresses, respectively, at the edge of the layers. These provide the appropriate boundary conditions that are to be used to calculate the streaming flow in the bulk, outside the boundary layers. The resulting formulae generalize to 3D the well-known expressions due to Schlichting (Phys. Z. 33 (1932) 327) and Longuet-Higgins (Philos. Trans. R. Soc. A 245 (1953) 535)
Failures of harbour walls at Malaga and Barcelona

The paper describes the failure of harbour walls which occurred at Malaga on 4th July 2004 and at Barcelona on 1st January 2007, associated with an inadequate consideration of the ground conditions in the light of the marine environment. At Malaga, there was an existing breakwater hence the new harbour was protected from the effect of the waves while at Barcelona, the construction of the quay wall proceeded at a faster rate than the breakwater. In both cases the wharf backfill was placed rapidly on the soft muds, progressing from the inland side. The paper discusses the importance of an overview including the ground investigation, engineering design, construction method and speed of construction
Lazy Lasso for local regression

Locally weighted regression is a technique that predicts the response for new data items from their neighbors in the training data set, where closer data items are assigned higher weights in the prediction. However, the original method may suffer from overfitting and fail to select the relevant variables. In this paper we propose combining a regularization approach with locally weighted regression to achieve sparse models. Specifically, the lasso is a shrinkage and selection method for linear regression. We present an algorithm that embeds lasso in an iterative procedure that alternatively computes weights and performs lasso-wise regression. The algorithm is tested on three synthetic scenarios and two real data sets. Results show that the proposed method outperforms linear and local models for several kinds of scenario
Formation energy of vacancies in FeCr alloys: Dependence on Cr concentration

A modified version of the concentration-dependent model (CDM) potential (A. Caro et al., Phys. Rev. Lett. 95 (2005) 075702) [1] has been developed to study defects in Fe–Cr for different Crconcentrations. A comparison between this new potential and DFT results for a variety of point defect configurations is performed in order to test its reliability for radiation damage studies. The effect of Crconcentration on the vacancyformationenergy in Fe–Cr alloys is analyzed in detail. This study shows a linear dependence of the vacancyformationenergy on Crconcentration for values above 6% of Cr. However, the formationenergy deviates from the linear interpolation in the region below 6% Crconcentration. In order to understand this behavior, the influence of the relative positions between Cr atoms and vacant sites on the vacancyformationenergy has been studied
TALISMAN+: Intelligent System for Follow-Up and Promotion of Personal Autonomy

The TALISMAN+ project, financed by the Spanish Ministry of  Science and Innovation, aims to research and demonstrate innovative solutions  transferable to society which offer services and products based on information  and communication technologies in order to promote personal autonomy in  prevention and monitoring scenarios. It will solve critical interoperability  problems among systems and emerging technologies in a context where  heterogeneity brings about  accessibility barriers not yet overcome and  demanded by the scientific, technological or social-health settings
Integrated planning for ecological urban regeneration

Considering that the vast majority of housing stock existing in 2011 will be used to satisfy residential needs in the year 2020 and beyond, ecological urban regeneration appears clearly as the key issue in relation to global urban sustainability for the most part of this century. Thus, if the 1992 Rio Summit identiﬁed the urban environment as the main arena where the global environmental crisis should be fought, 20 years later we must emphasize that it is mainly to the real cities and territories around us now where we should address our attentio
Real-time image processing for crop/weed discrimination in maize fields

This paper presents a computer vision system that successfully discriminates between weed patches and crop rows under uncontrolled lighting in real-time. The system consists of two independent subsystems, a fast image processing delivering results in real-time (Fast Image Processing, FIP), and a slower and more accurate processing (Robust Crop Row Detection, RCRD) that is used to correct the first subsystem's mistakes. This combination produces a system that achieves very good results under a wide variety of conditions. Tested on several maize videos taken of different fields and during different years, the system successfully detects an average of 95% of weeds and 80% of crops under different illumination, soil humidity and weed/crop growth conditions. Moreover, the system has been shown to produce acceptable results even under very difficult conditions, such as in the presence of dramatic sowing errors or abrupt camera movements. The computer vision system has been developed for integration into a treatment system because the ideal setup for any weed sprayer system would include a tool that could provide information on the weeds and crops present at each point in real-time, while the tractor mounting the spraying bar is movin
A fatigue damage model for seismic response of RC structures

Numerous damage models have been developed in order to analyze seismic behavior. Among the different possibilities existing in the literature, it is very clear that models developed along the lines of continuum damage mechanics are more consistent with the definition of damage as a phenomenon with mechanical consequences because they include explicitly the coupling between damage and mechanical behavior. On the other hand, for seismic processes, phenomena such as low cycle fatigue may have a pronounced effect on the overall behavior of the frames and, therefore, its consideration turns out to be very important. However, most of existing models evaluate the damage only as a function of the maximum amplitude of cyclic deformation without considering the number of cycles. In this paper, a generalization of the simplified model proposed by Cipollina et al. [Cipollina A, López-Hinojosa A, Flórez-López J. Comput Struct 1995;54:1113–26] is made in order to include the low cycle fatigue. Such a model employs in its formulation irreversible thermodynamics and internal state variable theory
Numerical analysis of axisymmetric shells by one-dimensional continuum elements suitable for high frequency excitations

Axisymmetric shells are analyzed by means of one-dimensional continuum elements by using the analogy between the bending of shells and the bending of beams on elastic foundation. The mathematical model is formulated in the frequency domain. Because the solution of the governing equations of vibration of beams are exact, the spatial discretization only depends on geometrical or material considerations. For some kind of situations, for example, for high frequency excitations, this approach may be more convenient than other conventional ones such as the finite element method
Efficient computation of the pressures developed during high-speed train passing events

The paper resumes the results obtained applying various implementations of the direct boundary element method (BEM) to the solution of the Laplace Equation governing the potential flow problem during everyday service manoeuvres of high-speed trains. In particular the results of train passing events at three different speed combinations are presented. Some recommendations are given in order to reduce calculation times which as is demonstrated can be cut down to not exceed reasonable limits even when using nowadays office PCs. Thus the method is shown to be a very valuable tool for the design engineer
A linear chained approach for service invocation in IP multimedia subsystem.

IP Multimedia Subsystem (IMS) is considered to provide multimedia services to users through an IP-based control plane. The current IMS service invocation mechanism, however, requires the Serving-Call Session Control Function (S-CSCF) invokes each Application Server (AS) sequentially to perform service subscription pro?le, which results in the heavy load of the S-CSCF and the long session set-up delay. To solve this issue, this paper proposes a linear chained service invocation mechanism to invoke each AS consecutively. By checking all the initial Filter Criteria (iFC) one-time and adding the addresses of all involved ASs to the ?Route? header, this new approach enables multiple services to be invoked as a linear chain during a session. We model the service invocation mechanisms through Jackson networks, which are validated through simulations. The analytic results verify that the linear chained service invocation mechanism can effectively reduce session set-up delay of the service layer and decrease the load level of the S-CSC
On Text-based Mining with Active Learning and Background Knowledge Using SVM

Abstract  Text mining, intelligent text analysis, text data mining and knowledge-discovery in text are generally used aliases to the process of extracting relevant and non-trivial information from text. Some crucial issues arise when trying to solve this problem, such as document representation and deficit of labeled data. This paper addresses these problems by introducing information from unlabeled documents in the training set, using the support vector machine (SVM) separating margin as the differentiating factor. Besides studying the influence of several pre-processing methods and concluding on their relative significance, we also evaluate the benefits of introducing background knowledge in a SVM text classifier. We further evaluate the possibility of actively learning and propose a method for successfully combining background knowledge and active learning. Experimental results show that the proposed techniques, when used alone or combined, present a considerable improvement in classification performance, even when small labeled training sets are available.http://dx.doi.org/10.1007/s00500-006-0080-
Stress intensity factor calculation based on the work of external forces

Abstract  The external forces method is a numerical method for K calculation based on the finite element method. It uses the work of the external forces W for the calculation of the energy release rate and is particularly advantageous when that forces are applied far from the crack front. The method was applied to a corner crack geometry with the objective of studying its accuracy. Good results were obtained for a wide range of virtual crack displacements (0.03% < ?a/a < 6%) considering 4 values of W along with a polynomial regression of order 3. For that choice of parameters the inaccuracy of K is mainly due to FEM errors. A great sensitivity of K to FEM errors was observed, however accurate values of K were obtained, with errors lower than 2 percent. So, the use of the external forces method for the calculation of K is recommended, considering its simplicity and accuracy.http://dx.doi.org/10.1023/A:101868493207
Polarisation measurements with a CdTe pixel array detector for Laue hard X-ray focusing telescopes

Abstract  Polarimetry is an area of high energy astrophysics which is still relatively unexplored, even though it is recognized that this type of measurement could drastically increase our knowledge of the physics and geometry of high energy sources. For this reason, in the context of the design of a Gamma-Ray Imager based on new hard-X and soft gamma ray focusing optics for the next ESA Cosmic Vision call for proposals (Cosmic Vision 2015-2025), it is important that this capability should be implemented in the principal on-board instrumentation. For the particular case of wide band-pass Laue optics we propose a focal plane based on a thick pixelated CdTe detector operating with high efficiency between 60–600keV. The high segmentation of this type of detector (1–2mm pixel size) and the good energy resolution (a few keV FWHM at 500keV) will allow high sensitivity polarisation measurements (a few % for a 10mCrab source in 106s) to be performed. We have evaluated the modulation Q factors and minimum detectable polarisation through the use of Monte Carlo simulations (based on the GEANT 4 toolkit) for on and off-axis sources with power law emission spectra using the point spread function of a Laue lens in a feasible configuration.http://dx.doi.org/10.1007/s10686-006-9048-
‘Observing cities’ social inequalities: a cartographic case study of Aveiro, Portugal

The aim of the study is to present a methodology and an instrument to study cities through a case study undertaken in the county of Aveiro, in Portugal. More specifically, it is to establish a typology of social areas, via the concerns that define quality of life. The data are from 1991 (the last published census), collected by INE (National Agency of Statistic), and desegregated for sub-sections (each subsection has about 300 inhabitants). Seven indicators were chosen, submitted to principal component analysis, and 4 factors were extracted: socio-professional status, ageing of population and buildings, accommodation capacity and precarious housing conditions. The cluster analysis permitted the identification, within each factor group, of sub-sections with different quality of life: high-medium, medium, low-medium and low.http://dx.doi.org/10.1016/S0264-2751(03)00033-
Systematic investigation of three-nucleon force effects in elastic scattering of polarized protons from deuterons at intermediate energies

The question, whether the high-quality nucleon-nucleon potentials can successfully describe the three-nucleon system, and to what extent three-nucleon forces (3NFs) play a role, has become very important in nuclear few-body physics. One kinematic region where effects because of 3NFs show up is in the minimum of the differential cross section of elastic nucleon-deuteron scattering. Another observable, which could give an indication about the contribution of the spin to 3NFs, is the vector analyzing power. To investigate the importance of 3NFs systematically over a broad range of intermediate energies, both observables of elastic proton-deuteron scattering have been measured at proton bombarding energies of 108, 120, 135, 150, 170, and 190 MeV, covering an angular range in the center-of-mass system between 30° and 170°. The results show unambiguously the shortcomings of calculations employing only two-body forces and the necessity of the inclusion of 3NFs. They also show the limitations of the results of the present day models for few-nucleon systems at backward angles, especially at higher beam energies. New calculations based on chiral perturbation theory are also presented and compared with the data at the lowest energy
Exciton-polariton behaviour in bulk and polycrystalline ZnO

We report detailed reflectance studies of the exciton–polariton structure of thin film polycrystalline ZnO\ud
and comparison with bulk crystal behaviour. Near-normal incidence reflectance spectra of these samples are\ud
fitted using a two-band dielectric response function. Our data show that the reflectance data in polycrystalline\ud
ZnO differ substantially from the bulk material, with Fabry–Perot oscillations at energies below the transverse A\ud
exciton and above the longitudinal B exciton in the films. In the strong interaction regime between these energies no\ud
evidence is seen of the normally rapid oscillations associated with the anomalous waves. We demonstrate that the\ud
strong interaction of the damped exciton with the photon leads to polaritons in this region with substantial damping\ud
such that the Fabry–Perot modes are eliminated. Good qualitative agreement is achieved between the model and\ud
data. The importance of the polariton model in understanding the reflectance data of polycrystalline material is clearly\ud
see
The TREC2001 video track: information retrieval on\ud
digital video information

The development of techniques to support content-based access to archives of digital video information has recently started to receive much attention from the research community. During 2001, the annual TREC activity, which has been benchmarking the performance of information retrieval techniques on a range of media for 10 years, included a ”track“ or activity which allowed investigation into approaches to support searching through a video library. This paper is not intended to provide a comprehensive picture of the different approaches taken by the TREC2001 video track participants but instead we give an overview of the TREC video search task and a thumbnail sketch of the approaches taken by different groups. The reason for writing this paper is to highlight the message from the TREC video track that there are now a variety of approaches available for searching and browsing through digital video archives, that these approaches do work, are scalable to larger archives and can yield useful retrieval performance for users. This has important implications in making digital libraries of video information attainable
Synthesis and characterisation of controllably functionalised polyaniline nanofibres

A novel method for functionalising solution based polyaniline (PAni) nanofibres is reported whereby the degree of side-chain attachment can be controllably altered. The covalent attachment of functional side-groups to the surface of PAni nanostructures is achieved by post-polymerisation reflux in the presence of a nucleophile and the functionalised nanomaterial can be purified by simple centrifugation. The technique is therefore easily scalable. We demonstrate that control over the extent of side-chain attachment can be achieved simply by altering the amount of nucleophile added during reflux. We provide evidence that covalently attached carboxlate side-chains influence the doping mechanism of polyaniline and can be used to introduce self-doping behaviour. Acid functionalised nanofibres remain redox active and retain their optical switching capabilities in response to changes in the local chemical environment, thus making them suitable for adaptive sensing applications
Structural, optical and magnetic properties of Ni-doped ZnO micro-rods grown by the spray pyrolysis method

Undoped and Ni-doped ZnO micro-rod arrays were successfully synthesized by the spray pyrolysis method on glass substrates. Analysis of the samples with x-ray diffraction and scanning electron microscopy showed that these micro-rod arrays had a polycrystalline wurtzite structure with a highly c-axis preferred orientation. Photoluminescence studies at both 300 K and 10 K show that the incorporation of nickel leads to a relative increase in the visible blue light band intensity. Magnetic measurements indicated that Ni-doped ZnO samples exhibit ferromagnetic behavior at room temperature, which is possibly related to the presence of point defects