pinecone/core-2020-05-10-deduplication huggingface dataset:
Inclusive, prompt and non-prompt J/ψ production at mid-rapidity in Pb-Pb collisions at √sNN = 2.76 TeV

The transverse momentum (p T) dependence of the nuclear modification factor R AA and the centrality dependence of the average transverse momentum 〈p T〉 for inclusive J/ψ have been measured with ALICE for Pb-Pb collisions at sNN−−−√=2.76 TeV in the e+e− decay channel at mid-rapidity (|y| < 0.8). The 〈p T〉 is significantly smaller than the one observed for pp collisions at the same centre-of-mass energy. Consistently, an increase of R AA is observed towards low p T. These observations might be indicative of a sizable contribution of charm quark coalescence to the J/ψ production. Additionally, the fraction of non-prompt J/ψ from beauty hadron decays, f B, has been determined in the region 1.5 < p T < 10 GeV/c in three centrality intervals. No significant centrality dependence of f B is observed. Finally, the R AA of non-prompt J/ψ is discussed and compared with model predictions. The nuclear modification in the region 4.5 < p T < 10 GeV/c is found to be stronger than predicted by most models
Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity

Prosenescence therapy has recently emerged as a novel therapeutic approach for treating cancer. However, this concept is challenged by conflicting evidence showing that the senescence-associated secretory phenotype (SASP) of senescent tumor cells can have pro- as well as antitumorigenic effects. Herein, we report that, in Pten-null senescent tumors, activation of the Jak2/Stat3 pathway establishes an immunosuppressive tumor microenvironment that contributes to tumor growth and chemoresistance. Activation of the Jak2/Stat3 pathway in Pten-null tumors is sustained by the downregulation of the protein tyrosine phosphatase PTPN11/SHP2, providing evidence for the existence of a novel PTEN/SHP2 axis. Importantly, treatment with docetaxel in combination with a JAK2 inhibitor reprograms the SASP and improves the efficacy of docetaxel-induced senescence by triggering a strong antitumor immune response in Pten-null tumors. Altogether, these data demonstrate that immune surveillance of senescent tumor cells can be suppressed in specific genetic backgrounds but also evoked by pharmacological treatments
Responsible implementation of expanded carrier screening

This document of the European Society of Human Genetics contains recommendations regarding responsible implementation of expanded carrier screening. Carrier screening is defined here as the detection of carrier status of recessive diseases in couples or persons who do not have an a priori increased risk of being a carrier based on their or their partners' personal or family history. Expanded carrier screening offers carrier screening for multiple autosomal and X-linked recessive disorders, facilitated by new genetic testing technologies, and allows testing of individuals regardless of ancestry or geographic origin. Carrier screening aims to identify couples who have an increased risk of having an affected child in order to facilitate informed reproductive decision making. In previous decades, carrier screening was typically performed for one or few relatively common recessive disorders associated with significant morbidity, reduced life-expectancy and often because of a considerable higher carrier frequency in a specific population for certain diseases. New genetic testing technologies enable the expansion of screening to multiple conditions, genes or sequence variants. Expanded carrier screening panels that have been introduced to date have been advertised and offered to health care professionals and the public on a commercial basis. This document discusses the challenges that expanded carrier screening might pose in the context of the lessons learnt from decades of population-based carrier screening and in the context of existing screening criteria. It aims to contribute to the public and professional discussion and to arrive at better clinical and laboratory practice guidelines.European Journal of Human Genetics advance online publication, 16 March 2016; doi:10.1038/ejhg.2015.271.status: publishe
Extraction of the strong neutron-proton mass difference from the charge symmetry breaking in pn -> d pi_0

We perform a complete calculation of charge symmetry breaking effects for the reaction pn --> d pi(0) at leading order in chiral perturbation theory. A new leading-order operator is included. From our analysis we extract delta m(N)(str), the strong contribution to the neutron-proton mass difference. The value obtained, delta m(N)(str) = (1.5 +/- 0.8 (exp.) +/- 0.5 (th.)) MeV, is consistent with the result based on the Cottingham sum rule. This agreement provides a non-trivial test of our current understanding of the chiral structure of QCD. (C) 2009 Elsevier B.V. All rights reserved
A remarkable relationship of the stable carbon isotopic compositions of wood and cellulose in tree-rings of the ropical speices Cariniana micrantha (Ducke) from Brazil

The stable isotopes of carbon were analysed in total wood and cellulose from the tree-rings of the tropical wood species Cariniana micrantha (Ducke). The aim was to examine the isotopic relationship between total wood and its cellulose over the last two and a half centuries. Although the correlation for the whole time period is very high (r = 0.96) it is remarkable that different sub-periods deviate strongly from this close relationship. Consequently, a good correlation from the subset of a longer isotopic record cannot necessarily prove its validity for the whole record. The study indicates that changes of the carbon isotopes of cellulose and of total wood show sometimes during short sub-periods different isotope patterns presumably caused by different environmental effects. Thorough calculations indicate that strong variations within the isotopic record especially changes of the isotopic level along a chronology lead to high correlations between δ13Cwood and δ13Ccel. Contrary thereto subsections with low isotopic variability lead to low correlations. The results imply that long term trends provide similar patterns. Therefore, if long term trends are of interest such as e.g. in climate reconstruction then total wood can be analysed in favour of cellulose, thus saving a tremendous amount of work. However, if short term aspects from a longer record are of interest, cellulose and total wood may sometimes provide different information. In addition it is hypothesized that during intervals of low isotopic variability the proportions of the various wood components may change relative to each other, leading for certain time intervals to different isotope patterns
Preparation and sintering behaviour of La$_{5.4}$WO$_{12−δ}$ asymmetric membranes with optimised microstructure for hydrogen separation

La5.4WO12−δ (LaWO) is a promising membrane candidate for a variety of H2-related applications due to its appreciable levels of mixed proton–electron conduction and its stability in moist reducing atmospheres at elevated temperatures. Governed by Wagner theory, the H2 permeation performance of a membrane can be enhanced by reducing its thickness. Therefore, the present work deals with preparing LaWO supported membranes with reduced thickness and optimised microstructure. Combining a dense membrane with a porous supporting layer is associated with mismatched sintering rates, which ultimately lead to bending effects. Therefore, the sintering behaviour of both the dense membrane and the porous substrate must be carefully adjusted to each other. For this purpose, single and co-fired membrane and substrate layers were produced by tape casting. Sintering experiments were carried out with an optical dilatometer. The shrinkage and microstructural evolution of the layers were evaluated in terms of the anisotropic shrinkage forces and the membrane rigidness counteracting the substrate shrinkage. The results were used to develop asymmetric LaWO membranes with optimal microstructure. High membrane density was combined with a substrate porosity of ~30% and minimised bending (40 µm). The LaWO membrane–substrate assembly displayed a He leakage of 10−5 hPa dm³ cm−2 s−1, which is a value that satisfies further practical demands
Spin-5 Casimir operator its three-point functions with two scalars

By calculating the second-order pole in the operator product expansion (OPE) between the spin-3 Casimir operator and the spin-4 Casimir operator known previously, the spin-5 Casimir operator is obtained in the coset model based on $ \left( {A_{N-1}^{(1)}\oplus A_{N-1}^{(1) },\  A_{N-1}^{(1) }} \right) $ at level ( k, 1). This spin-5 Casimir operator consisted of the quintic, quartic (with one derivative) and cubic (with two derivatives) WZW currents contracted with SU( N ) invariant tensors. The three-point functions with two scalars for all values of ’t Hooft coupling in the large N limit were obtained by analyzing the zero-mode eigenvalue equations carefully. These three-point functions were dual to those in AdS 3 higher spin gravity theory with matter. Furthermore, the exact three-point functions that hold for any finite N and k are obtained. The zero mode eigenvalue equations for the spin-5 current in CFT coincided with those of the spin-5 field in asymptotic symmetry algebra of the higher spin theory on the AdS 3 . This paper also describes the structure constant appearing in the spin-4 Casimir operator from the OPE between the spin-3 Casimir operator and itself for N = 4 , 5 in the more general coset minimal model with two arbitrary levels ( k 1 , k 2 )
Enhancement of the H ± W ∓ Z vertex in the three scalar doublet model

We compute one-loop induced trilinear vertices with physical charged Higgs bosons H ± and ordinary gauge bosons, i.e., H ± W ∓ Z and H ± W ∓ γ , in the model with two active plus one inert scalar doublet fields under a Z 2 (unbroken) × Z ˜ 2 $$ {\tilde{Z}}_2 $$ (softly-broken) symmetry. The Z 2 and Z ˜ 2 $$ {\tilde{Z}}_2 $$ symmetries are introduced to guarantee the stability of a dark matter candidate and to forbid the flavour changing neutral current at the tree level, respectively. The dominant form factor F Z of the H ± W ∓ Z vertex can be enhanced by effects of extra scalar boson loop contributions. We find that, in such a model, | F Z | 2 can be one order of magnitude larger than that predicted in two Higgs doublet models, under the constraints from vacuum stability, perturbative unitarity and the electroweak precision observables. In addition, the branching fraction of the H ± → W ± Z ( H ± → W ± γ ) mode can be of order 10 (1)% level when the mass of H ± is below the top quark mass. Such a light H ± is allowed by the so-called Type-I and Type-X Yukawa interactions which appear under the classification of the Z ˜ $$ \tilde{Z} $$ charge assignment of the quarks and leptons. We also calculate the cross sections for the processes H ± → W ± Z and H ± → W ± γ onset by the top quark decay t → H ± b and electroweak H ± production at the LHC
The triple alpha reaction rate and the 2+ resonances in 12C

The triple alpha rate is obtained from the three-body bound and continuum states computed in a large box. The results from this genuine full three-body calculation are compared with standard reference rates obtained by two sequential two-body processes. The fairly good agreement relies on two different assumptions about the lowest 2+ resonance energy. With the same 2+ energy the rates from the full three-body calculation are smaller than those of the standard reference. We discuss the rate dependence on the experimentally unknown 2+ energy. Substantial deviations from previous results appear for temperatures above 3 GK. © 2010 Elsevier B.V.This work was partly supported by funds provided by DGI of MEC (Spain) under contract No. FIS2008-01301. One of us (R.D.) acknowledges support by a Ph.D. I3P grant from CSIC and the European Social Fund.Peer Reviewe
Evaluation of the use of different coals in chemical looping combustion using a bauxite waste as oxygen carrier

The interest in the use of solid fuels such as coal in Chemical Looping Combustion is\ud
growing because of the benefits of the direct use of coal in this technology on the reduction\ud
of the costs linked to carbon dioxide capture. In CLC, the oxygen needed for the combustion\ud
is supplied by a solid oxygen carrier therefore avoiding the direct contact between fuel and\ud
air. Focusing on the use of solid fuels in the In-Situ Gasification Chemical Looping\ud
Combustion (iG-CLC), the oxygen carrier is mixed with the coal in the fuel reactor, where\ud
gasification of the coal and reaction of the gasification products with the oxygen carrier\ud
particles takes place. In this process, the possible loss of oxygen carrier together with the\ud
ashes makes it interesting to find inexpensive materials to be used as carriers, such as natural\ud
minerals or industrial residues. In this work, an Fe-based bauxite waste is used as oxygen\ud
carrier in the combustion of different types of coal. Experiments were performed in a TGA\ud
and a batch fluidized bed (FB) using both coal and char from the corresponding coal. The\ud
influence of temperature as well as the gasifying agent composition on the performance of\ud
coal conversion in an iG-CLC process was evaluated. Tests in a thermogravimetric analyzer\ud
(TGA) revealed direct char combustion by oxygen in the bauxite waste material, but no\ud
evidences of such direct combustion were found in the experiments in the batch fluidized\ud
bed. In this case, gasification of char by H2O or CO2 was found as a necessary step in char\ud
conversion. Using steam as gasifying agent, higher char gasification rates were observed than\ud
using CO2 and in all conditions lignite presented the highest char gasification rate. At 980ºC,\ud
the lignite char gasification rate in CO2 doubled the value obtained with anthracite using\ud
steam, indicating that recirculated CO2 can be fed to the fuel reactor of a CLC system if\ud
lignite is used as fuel. For the rest of the fuels, it was possible to use a mixture of H2O and\ud
CO2 as gasifying agent without decreasing the feasibility of the iG-CLC process. The bauxite\ud
3\ud
waste was able to burn the gaseous products generated during the gasification of the different\ud
types of coal with high combustion efficiencies.The authors thank the Spanish Ministry for Science and Innovation for the financial support\ud
via the ENE2010-19550 project. T. Mendiara thanks for the “Juan de la Cierva” post-doctoral\ud
contract awarded by this Ministry. The authors also thank to Alcoa Europe-Alúmina\ud
Española S.A. for providing the solid material used in this work. G. Ferrer is acknowledged\ud
for his contribution to the experimental results.Peer reviewe
Randomized observation periods for the compound poisson risk model: the discounted penalty function

In the framework of collective risk theory, we consider a compound Poisson risk model for the surplus process where the process (and hence ruin) can only be observed at random observation times. For Erlang(n) distributed inter-observation times, explicit expressions for the discounted penalty function at ruin are derived. The resulting model contains both the usual continuous-time and the discrete-time risk model as limiting cases, and can be used as an effective approximation scheme for the latter. Numerical examples are given that illustrate the effect of random observation times on various ruin-related quantities.postprin
Laser-induced forward transfer of liquids : Study of the droplet ejection process

Laser-induced forward transfer  LIFT  is a laser direct-write technique that offers the possibility of printing patterns with a high spatial resolution from a wide range of materials in a solid or liquid state, such as conductors, dielectrics, and biomolecules in solution. This versatility has made LIFT\ud
a very promising alternative to lithography-based processes for the rapid prototyping of biomolecule microarrays. Here, we study the transfer process through the LIFT of droplets of a solution suitable\ud
for microarray preparation. The laser pulse energy and beam size were systematically varied, and the effect on the transferred droplets was evaluated. Controlled transfers in which the deposited droplets displayed optimal features could be obtained by varying these parameters. In addition, the\ud
transferred droplet volume displayed a linear dependence on the laser pulse energy. This dependence allowed determining a threshold energy density value, independent of the laser focusing conditions, which acted as necessary conditions for the transfer to occur. The corresponding sufficient condition was given by a different total energy threshold for each laser beam dimension. The threshold energy\ud
density was found to be the dimensional parameter that determined the amount of the transferred liquid per laser pulse, and there was no substantial loss of material due to liquid vaporization during the transfer.Postprint (published version
The VMC Survey. XVIII. Radial dependence of the low-mass, 0.55--0.82
  $M_\odot$ stellar mass function in the Galactic globular cluster 47 Tucanae

We use near-infrared observations obtained as part of the {\sl Visible and
Infrared Survey Telescope for Astronomy} (VISTA) Survey of the Magellanic
Clouds (VMC), as well as two complementary {\sl Hubble Space Telescope} ({\sl
HST}) data sets, to study the luminosity and mass functions as a function of
clustercentric radius of the main-sequence stars in the Galactic globular
cluster 47 Tucanae. The {\sl HST} observations indicate a relative deficit in
the numbers of faint stars in the central region of the cluster compared with
its periphery, for $18.75\leq m_{\rm F606W}\leq 20.9$ mag (corresponding to a
stellar mass range of $0.55<m_\ast/{M_\odot}<0.73$). The stellar number counts
at $6.7'$ from the cluster core show a deficit for $17.62\leq m_{\rm F606W}\leq
19.7$ mag (i.e., $0.65<m_\ast/{M_\odot}<0.82$), which is consistent with
expectations from mass segregation. The VMC-based stellar mass functions
exhibit power-law shapes for masses in the range $0.55<m_\ast/{M_\odot}< 0.82$.
These power laws are characterized by an almost constant slope, $\alpha$. The
radial distribution of the power-law slopes $\alpha$ thus shows evidence of the
importance of both mass segregation and tidal stripping, for both the first-
and second-generation stars in 47 Tuc.Comment: 9 pages, 9 figures, accepted to publication in Ap
An extension of two-Higgs-doublet model and the excesses of 750 GeV
  diphoton, muon g-2 and $h\to\mu\tau$

In this paper we simultaneously explain the excesses of the 750 GeV diphoton,
muon g-2 and $h\to \mu\tau$ in an extension of the two-Higgs-doublet model
(2HDM) with additional vector-like fermions and a CP-odd scalar singlet ($P$)
which is identified as the 750 GeV resonance. This 750 GeV resonance has a
mixing with the CP-odd scalar ($A$) in 2HDM, which leads to a coupling between
$P$ and the SM particles as well as a coupling between $A$ and the vector-like
fermions. Such a mixing and couplings are strongly constrained by
$\tau\to\mu\gamma$, muon g-2 and the 750 GeV diphoton data. We scan over the
parameter space and find that such an extension can simultaneously account for
the observed excesses of 750 GeV diphoton, muon g-2 and $h\to \mu\tau$. The 750
GeV resonance decays in exotic modes, such as $P\to hA$, $P\to HZ$, $P\to HA$
and $P\to W^\pm H^\mp$, and its width can be dozens of GeV and is sensitive to
the mixing angle.Comment: 18 pages, 3 figures and references adde
The $B\to K^*$ form factors on the lattice

The extraction of the $B\to K^*$ transition form factors from lattice data is
studied, applying non-relativistic effective field theory in a finite volume.
The possible mixing of $\pi K$ and $\eta K$ states is taken into account. The
two-channel analogue of the Lellouch-L\"uscher formula is reproduced. Due to
the resonance nature of the $K^*$, an equation is derived, which allows to
determine the form factors at the pole position in a process-independent
manner. The infinitely-narrow width approximation of the results is discussed.Comment: 29 pages, 4 figure
Exposing sequence learning in a double-step task.

Is it possible to learn to perform a motor sequence without awareness of the sequence? In two experiments, we presented participants with the most elementary sequence: an alternation between two options. We used a double-step pointing task in which the final position of the target alternated between two quite similar values. The task forced participants to start moving before the final target was visible, allowing us to determine participants’ expectations about the final target position without explicitly asking them. We tracked participants’ expectations (and thus motor sequence learning) by measuring the direction of the initial part of the movement, before any response to the final step. We found that participants learnt to anticipate the average size of the final step, but that they did not learn the sequence. In a second experiment, we extended the duration of the learning period and increased the difference in size between the target position changes. Some participants started anticipating the step size in accordance with the sequence at some time during the experiment. These participants reported having noticed the simple sequence. The participants who had not noticed the sequence did not move in anticipation of the sequence. This suggests that participants who did not learn this very simple sequence explicitly also did not learn it implicitly
Creating a public tool to assess and promote transparency in global land deals: The experience of the Land Matrix

The Beta version of the Land Matrix (Land Matrix 2012) was launched in April 2012 as a tool to promote public participation in building a constantly evolving database on large-scale land deals, and making the data visible and understandable. The aim of the Land Matrix partnership is to promote transparency and open data in decision-making over land and investment, as a step towards greater accountability. Since its launch, the Land Matrix has attracted a high degree of attention, and stirred some controversy. It provides valuable lessons on the challenges and benefits of promoting open data on practices that are often shrouded in secrecy. This paper critically examines the ongoing efforts by the Land Matrix partnership to build a public tool to promote greater transparency in decision-making over land and investment at a global level. It intends to provoke discussion of the extent to which such a tool can ultimately promote greater transparency and be a step towards greater accountability and improved decision-making. It will present the Land Matrix and its value addition, before detailing the challenges it encountered related to the measurement of the large-scale land acquisition phenomenon. It will then specify how it intends to address these issues in order to establish a dynamic and participatory tool for open development. (Résumé d'auteur
Charged-particle multiplicities in pp interactions at root s=900 GeV measured with the ATLAS detector at the LHC ATLAS collaboration

The first measurements from proton-proton collisions recorded with the ATLAS detector at the LHC are presented. Data were collected in December 2009 using a minimum-bias trigger during collisions at a centre-of-mass energy of 900 GeV. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity, and the relationship between mean transverse momentum and charged-particle multiplicity are measured for events with at least one charged particle in the kinematic range vertical bar eta vertical bar < 2.5 and p(T) > 500 MeV. The measurements are compared to Monte Carlo models of proton-proton collisions and to results from other experiments at the same centre-of-mass energy. The charged-particle multiplicity per event and unit of pseudorapidity eta = 0 is measured to be 1.333 +/- 0.003(stat.) +/- 0.040(syst.), which is 5-15% higher than the Monte Carlo models predict