pinecone/core-2020-05-10-deduplication huggingface dataset:
TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition

Ovarian cancer (OC) is the second leading cause of gynecological cancer death worldwide. Although the list of biomarkers is still growing, molecular mechanisms involved in OC development and progression remain elusive. We recently demonstrated that lower expression of the molecular chaperone TRAP1 in OC patients correlates with higher tumor grade and stage, and platinum resistance. Herein we show that TRAP1 is often deleted in high-grade serous OC patients (N=579), and that TRAP1 expression is correlated with the copy number, suggesting this could be one of the driving mechanisms for the loss of TRAP1 expression in OC. At molecular level, downregulation of TRAP1 associates with higher expression of p70S6K, a kinase frequently active in OC with emerging roles in cell migration and tumor metastasis. Indeed, TRAP1 silencing in different OC cells induces upregulation of p70S6K expression and activity, enhancement of cell motility and epithelial-mesenchymal transition (EMT). Consistently, in a large cohort of OC patients, TRAP1 expression is reduced in tumor metastases and directly correlates with the epithelial marker E-Cadherin, whereas it inversely correlates with the transcription factor Slug and the matrix metallopeptidases 2 and 9. Strikingly, pharmacological inhibition of p70S6K reverts the high motility phenotype of TRAP1 knock-down cells. However, although p70S6K inhibition or silencing reduces the expression of the transcription factors Snail and Slug, thus inducing upregulation of E-Cadherin expression, it is unable to revert EMT induced by TRAP1 silencing; furthermore, p70S6K did not show any significant correlation with EMT genes in patients, nor with overall survival or tumor stage, suggesting an independent and predominant role for TRAP1 in OC progression. Altogether, these results may provide novel approaches in OC with reduced TRAP1 expression, which could be resistant to therapeutic strategies based on the inhibition of the p70S6K pathway, with potential future intervention in OC invasion and metastasis
Computing the everyday: Social media as data platforms

We conceive social media platforms as sociotechnical entities that variously shape user platform involvement and participation. Such shaping develops along three fundamental data operations that we subsume under the terms of encoding, aggregation, and computation. Encoding entails the engineering of user platform participation along narrow and standardized activity types (e.g., tagging, liking, sharing, following). This heavily scripted platform participation serves as the basis for the procurement of discrete and calculable data tokens that are possible to aggregate and, subsequently, compute in a variety of ways. We expose these operations by investigating a social media platform for shopping. We contribute to the current debate on social media and digital platforms by describing social media as posttransactional spaces that are predominantly concerned with charting and profiling the online predispositions, habits, and opinions of their user base. Such an orientation sets social media platforms apart from other forms of mediating online interaction. In social media, we claim, platform participation is driven toward an endless online conversation that delivers the data footprint through which a computed sociality is made the source of value creation and monetization
Spatial distribution of early red lesions is a risk factor for development of vision-threatening diabetic retinopathy

Aims/hypothesis Diabetic retinopathy is characterised by morphological lesions related to\ud
disturbances in retinal blood flow. It has previously been shown that the early development\ud
of retinal lesions temporal to the fovea may predict the development of treatment-requiring\ud
diabetic maculopathy. The aim of this study was to map accurately the area where lesions\ud
could predict progression to vision-threatening retinopathy.\ud
Methods The predictive value of the location of the earliest red lesions representing\ud
haemorrhages and/or microaneurysms was studied by comparing their occurrence in a\ud
group of individuals later developing vision-threatening diabetic retinopathy with that in a\ud
group matched with respect to diabetes type, age, sex and age of onset of diabetes mellitus\ud
who did not develop vision-threatening diabetic retinopathy during a similar observation\ud
period.\ud
Results The probability of progression to vision-threatening diabetic retinopathy was higher\ud
in a circular area temporal to the fovea, and the occurrence of the first lesions in this area\ud
was predictive of the development of vision-threatening diabetic retinopathy. The calculated\ud
peak value showed that the risk of progression was 39.5% higher than the average. There\ud
was no significant difference in the early distribution of lesions in participants later\ud
developing diabetic maculopathy or proliferative diabetic retinopathy.\ud
Conclusions/interpretation The location of early red lesions in diabetic retinopathy is\ud
predictive of whether or not individuals will later develop vision-threatening diabetic\ud
retinopathy. This evidence should be incorporated into risk models used to recommend\ud
control intervals in screening programmes for diabetic retinopathy
Thresholds for Error Probability Measures of Business Process Models

The quality of conceptual business process models is highly relevant for the design of corresponding information systems.\ud
In particular, a precise measurement of model characteristics can be beneficial from a business perspective, helping to save\ud
costs thanks to early error detection. This is just as true from a software engineering point of view. In this latter case, models facilitate stakeholder communication and software system design. Research has investigated several proposals as regards measures for business process models, from a rather correlational perspective. This is helpful for understanding, for example size and complexity as general driving forces of error probability. Yet, design decisions usually have to build on thresholds, which can reliably indicate that a certain counter-action has to be taken. This cannot be achieved only by providing measures; it requires a systematic identification of effective and meaningful thresholds. In this paper, we derive thresholds for a set of structural measures for predicting errors in conceptual process models. To this end, we use a collection of 2,000 business process models from practice as a means of determining thresholds, applying an adaptation\ud
of the ROC curves method. Furthermore, an extensive validation of the derived thresholds was conducted by using\ud
429 EPC models from an Australian financial institution. Finally, significant thresholds were adapted to refine existing modeling guidelines in a quantitative way
Tourist destination marketing: from sustainability myopia to memorable experiences

This study explores the way in which consumers interpret and process the marketing and communication of sustainable forms of tourism in destinations, in order to inform policy makers about the appropriateness of different types of sustainability messages. Through a thematic analysis of focus group data, we explore the ways in which consumers engage with, and respond to, explicit discourses of sustainability in marketing a tourist destination. We find that overt discourses of sustainability are often rejected by consumers, thus suggesting that messages concerned with sustainability should place greater priority upon consumer experience and opportunities afforded by the purchase and consumption of the travel experience (that happens to be sustainable) they can expect at their chosen destination. As such, commitments to sustainability manifest within organisational philosophy and practice should not drive the principle, overt discourse communicated to consumers. Rather, as embedded within product and practice, such messages would have greater power and effect if they occupied a more subliminal position in destination marketing materials
The relationship between budgetary expenditure and economic growth in Poland

This paper investigates the association between different kinds of budgetary expenditure and economic growth of Poland. The empirical analysis makes use of linear and nonlinear Granger causality tests to evaluate the applicability of Wagner’s Law and that of the contrasting Keynesian theory.We employ aggregate and disaggregate
data with the sub-categories of most important budgetary expenditure, including health care and social security, education and science, national defence and public
security expenditure and government administration expenditure for the period Q1 2000 to Q3 2008. This causality analysis indicates that total relation between budgetary expenditure and economic growth is consistent with Keynesian theory. The results of our computations have important policy implications. In case of Poland the health
care expenditure was found to be as important for economic growth as expenditures on education and science. Furthermore, in order to stimulate economic growth, Polish
government should consider reallocating some of national defence, public security and government administration expenditure to health care, social security, education
and science expenditure.
2D fuzzy Anti-de Sitter space from matrix models

We study the fuzzy hyperboloids AdS^2 and dS^2 as brane solutions in matrix
models. The unitary representations of SO(2,1) required for quantum field
theory are identified, and explicit formulae for their realization in terms of
fuzzy wavefunctions are given. In a second part, we study the (A)dS^2 brane
geometry and its dynamics, as governed by a suitable matrix model. In
particular, we show that trace of the energy-momentum tensor of matter induces
transversal perturbations of the brane and of the Ricci scalar. This leads to a
linearized form of Henneaux-Teitelboim-type gravity, illustrating the mechanism
of emergent gravity in matrix models.Comment: 25 page
Semiclassical force for electroweak baryogenesis: three-dimensional derivation

We derive a semiclassical transport equation for fermions propagating in the presence of a CP-violating planar bubble wall at a first order electroweak phase transition. Starting from the Kadanoff-Baym (KB) equation for the two-point (Wightman) function we perform an expansion in gradients, or equivalently in the Planck constant h-bar. We show that to first order in h-bar the KB equations have a spectral solution, which allows for an on-shell description of the plasma excitations. The CP-violating force acting on these excitations is found to be enhanced by a boost factor in comparison with the 1+1-dimensional case studied in a former paper. We find that an identical semiclassical force can be obtained by the WKB method. Applications to the MSSM are also mentioned
LHC prospects for minimal decaying dark matter

We study the possible signals at LHC of the minimal models   of decaying dark matter. Those models are characterized by the fact   that DM interacts with SM particles through renormalizable coupling   with an additional heavier charged state. Such interaction allows to   produce a substantial abundance of DM in the early Universe via the   decay of the charged heavy state, either in- or out-of-equilibrium.   Moreover additional couplings of the charged particle open up decay   channels for the DM, which can nevertheless be sufficiently   long-lived to be a good DM candidate and within reach of future   Indirect Detection observations.  We compare the cosmologically   favored parameter regions to the LHC discovery reach and discuss the   possibility of simultaneous detection of DM decay in Indirect   Detection
Characterization and performances of a monitoring ionization chamber dedicated to IBA-universal irradiation head for Pencil Beam Scanning

Every radiotherapy center has to be equipped with real-time beam monitoring devices. In 2008, the medical application group from the Laboratory of Corpuscular Physics (LPC Caen) developed an Ionization Chamber in collaboration with the company IBA (Ion Beam Applications). This monitoring device called IC2/3 was developed to be used in IBAs universal irradiation head for Pencil Beam Scanning (PBS). The objectives presented in this article are to characterize the IC2/3 monitor in the energy and ux ranges used in protontherapy. The equipment has been tested with an IBAs cyclotronable to deliver proton beams from 70 to 230 MeV. This beam monitoring device has been validated and is now installed at the Westdeutsches Protonentherapiezentrum Essen protontherapy center (WPE, Germany). The results obtained in both terms of spatial resolution and dose measurements are at least equal to the initials speci cations needed for PBS purposes. The detector measures the dose with a relative precision better than 1% in the range 0.5 Gy/min to 8 Gy/min while the spatial resolution is higher than 250 m. The technology has been patented and ve IC2/3 chambers were delivered to IBA. Nowadays, IBA produces the IC2/3 beam monitoring device as part of its Proteus 235 produc
Mapping scientific institutions

International audienceWe have developed a set of routines that allows to draw easily different maps of the research carried out in a scientific institution. Our toolkit uses OpenSource elements to analyze bibliometric data gathered from the Web Of Science. We take the example of our institution, ENS de Lyon, to show how different maps, using co-occurrence (of authors, keywords, institutions...) and bibliographic coupling can be built. These maps may become a valuable tool for discussing institutions' policies, as they offer different views on the institution at a global scale
New in vitro and in vivo models to evaluate antibiotic efficacy in Staphylococcus aureus prosthetic vascular graft infection

International audienceOBJECTIVE: Prosthetic vascular graft infection (PVGI) is an emerging disease, mostly caused by staphylococci, with limited data regarding efficacy of current antistaphylococcal agents. We aimed to assess the efficacy of different antibiotic regimens. METHODS: Six different strains of MSSA and MRSA were used. We compared results of minimal biofilm inhibitory and eradicating concentrations (MBICs and MBECs) obtained with a Calgary Biofilm Pin Lid Device (CBPD) with those yielded by an original Dacron(®)-related minimal inhibitory and eradicating concentration measure model. We then used a murine model of Staphylococcus aureus vascular prosthetic material infection to evaluate efficacy of different antibiotic regimens: vancomycin and daptomycin combined or not with rifampicin for MRSA and the same groups with cloxacillin and cloxacillin combined with rifampicin for MSSA. RESULTS: We demonstrated that classical measures of MBICs and MBECs obtained with a CPBD could overestimate the decrease in antibiotic susceptibility in material-related infections and that the nature of the support used might influence the measure of biofilm susceptibility, since results yielded by our Dacron(®)-related minimal eradicating assay were lower than those found with a plastic device. In our in vivo model, we showed that daptomycin was significantly more bactericidal than comparators for some strains of MRSA or MSSA but not for all. For the majority of strains, it was as efficient as comparators. The addition of rifampicin to daptomycin did not enhance daptomycin efficacy. CONCLUSIONS: Despite the heterogeneity of results according to bacterial strains, these innovative models represent an option to better evaluate the in vitro efficacy of antibiotics on Dacron(®)-related biofilm S. aureus infections, and to screen different antibiotic regimens in a mouse model of PVGIs
Determination of the topological charge of a twisted beam with a Fresnel bi-prism

International audienceThe self-interference pattern of a Laguerre Gaussian beam using a Fresnel bi-prism is shown to be very different from what could be expected from a usual laser beam. Actually it resembles the interference pattern that could be obtained using a double slit experiment. The interferences are shifted and the topological charge and its sign can be readily determined considering the shift order of the pattern only. However, since there is no diffraction nor absorption loses unlike in a double slit interference, such a set up could be used even for low power twisted beams or beams with high topological charge. Even fractional topological charges could be determined with an absolute precision of 0.05
Qualitative identification of cracks using 3D transient elastodynamic topological derivative: formulation and FE implementation

International audienceA time-domain topological derivative (TD) approach is developed for transient elastic-wave imaging of buried cracks. The TD, which quantifies the sensitivity of the misfit cost functional to the creation at a specified location of an infinitesimal trial crack, is expressed in terms of the time convolution of the free field and an adjoint field as a function of that specified location and of the trial crack shape. Following previous studies on cavity identification in similar conditions, the TD field is here considered as a natural and computationally efficient approach for defining a crack location indicator function. This study emphasizes the implementation and exploitation of TD fields using the standard displacement-based FEM, a straightforward exploitation of the relevant sensitivity formulation established here. Results on several numerical experiments on 3D elastodynamic and acoustic configurations are reported and discussed, allowing to assess and highlight many features of the proposed TD-based fast qualitative crack identification, including its ability to identify multiple cracks and its robustness against data noise
Planning oncologists of ambulatory care units

International audienceThis paper addresses the problem of determining the work schedule, called medical planning, of oncologists for chemotherapy of oncology patients at ambulatory care units. A mixed integer programming (MIP) model is proposed for medical planning in order to best balance bed capacity requirements under capacity constraints of key resources such as beds and oncologists. The most salient feature of the MIP model is the explicit modeling of specific features of chemotherapy such as treatment protocols. The medical planning problem is proved to be NP-complete. A three-stage approach is proposed for determining good medical planning in reasonable computational time. From numerical experiments based on field data, the three-stage approach takes less than 10 min and always outperforms the direct application of MIP solvers with 10 h CPU time. Compared with the current planning, the three-stage approach reduces the peak daily bed capacity requirement by 20 h to 45 h while the maximum theoretical daily bed capacity is 162 h
Multisite luminescence of rare earth doped TiO2 anatase nanoparticles

Eu3+, Sm3+ and Tb3+ ions have been incorporated into anatase TiO2 nanocrystals via hydrolytic sol–gel method. Pure anatase phase was confirmed with XRD and TEM measurements. Band gap energies change slightly with rareearth incorporation, from 3.32 eV for undoped TiO2 to 3.15 eV, 3.25 eV and 3.29 eV for Tb3+, Sm3+ and Eu3+doped TiO2. Photoluminescence of Eu3+ and Sm3+ originated from three different sites in TiO2 nanocrystals have been identified with the laser-excited site-selective spectroscopy measurements at 10 K. One site exhibits broad emission peaks, which are ascribed to the distorted lattice site near the surface. Other two sites, associated with the inner lattice, show significantly sharper fluorescence lines as a consequence of an ordered crystalline environment. The emission decays of Eu3+ and Sm3+ have similar values for inner-lattice sites and longer lifetimes for near-surface sites. The luminescence of Tb3+doped TiO2 nanocrystals was immeasurably weak
Short Synthesis of Novel Recyclable Chiral Bifunctional Thioureas from Aminoalkyl Polystyrene and their use as Organocatalysts in Stereoselective aza-Henry Reaction

Producción CientíficaA series of supported bifunctional thioureas has been prepared, in one or two steps, from commercially available aminoalkyl polystyrene resins. They differ in the length of the tether attaching the thiourea to the polymer chain, and the nature of the amino thiourea component. All the materials are able to promote stereoselective aza-Henry reaction with very good stereoselection, and they can be recycled maintaining the catalytic activity.Ministerio de Economía, Industria y Competitividad (CTQ2014-59870-P)Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA064U13
Analysis and resolution of the ground-state degeneracy of the two-component Bose-Hubbard model

We study the degeneracy of the ground-state energy E of the two-component Bose-Hubbard model and of the perturbative correction E1 . We show that the degeneracy properties of E and E1 are closely related to the connectivity properties of the lattice. We determine general conditions under which E is nondegenerate. This analysis is then extended to investigate the degeneracy of E1 . In this case, in addition to the lattice structure, the degeneracy also depends on the number of particles present in the system. After identifying the cases in which E1 is degenerate and observing that the standard (degenerate) perturbation theory is not applicable, we develop a method to determine the zeroth-order correction to the ground state by exploiting the symmetry properties of the lattice. This method is used to implement the perturbative approach to the two-component Bose-Hubbard model in the case of degenerate E1 and is expected to be a valid tool to perturbatively study the asymmetric character of the Mott insulator to superfluid transition between the particle and hole sid
Regional centrality and tax competition for FDI

We examine a trade model where three countries compete for an exogenous number of firms. In our hub- and- spoke framework, one country is the hub through which all trade with and between spokes takes place. We establish the distribution of industrial activity in the absence of taxes and compare it to the equilibrium when countries compete to attract firms. Even when all countries have the same size, the centrality of the hub sets it apart. We determine how this trading pattern matters, comparing it to a structure with direct trade between all countries. The implications of international tax competition are also examined
Cross host transmission in the emergence of MERS coronavirus

Coronaviruses (CoVs) able to infect humans emerge through cross-host transmission from animals. There is substantial evidence that the recent Middle East respiratory syndrome (MERS)-CoV outbreak is fueled by zoonotic transmission from dromedary camels. This is largely based on the fact that closely related viruses have been isolated from this but not any other animal species. Given the widespread geographical distribution of dromedaries found seropositive for MERS-CoV, continued transmission may likely occur in the future. Therefore, a further understanding of the cross host transmission of MERS-CoV is needed to limit the risks this virus poses to man