pinecone/core-2020-05-10-deduplication huggingface dataset:
Search for high-mass resonances decaying into τ-lepton pairs in pp collisions at √s = 7 TeV

A search for high-mass resonances decaying into τ[superscript +]τ[superscript −] is performed using a data sample of pp collisions at √s = 7 TeV. The data were collected with the CMS detector at the LHC and correspond to an integrated luminosity of 4.9 fb[superscript −1]. The number of observed events is in agreement with the standard model prediction. An upper limit on the product of the resonance cross section and branching fraction into τ-lepton pairs is calculated as a function of the resonance mass. Using the sequential standard model resonance Z′[subscript SSM] and the superstring-inspired E[subscript 6] model with resonance Z′[subscript ψ] as benchmarks, resonances with standard model couplings with masses below 1.4 and 1.1 TeV, respectively, are excluded at 95% confidence level.United States. Dept. of EnergyNational Science Foundation (U.S.
The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex

Soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) and Sec1/Munc18 (SM) proteins constitute the core of an ancient vesicle fusion machine that diversified into distinct sets that now function in different trafficking steps in eukaryotic cells. Deciphering their precise mode of action has proved challenging. SM proteins are thought to act primarily through one type of SNARE protein, the syntaxins. Despite high structural similarity, however, contrasting binding modes have been found for different SM proteins and syntaxins. Whereas the secretory SM protein Munc18 binds to the ‟closed conformation” of syntaxin 1, the ER–Golgi SM protein Sly1 interacts only with the N-peptide of Sed5. Recent findings, however, indicate that SM proteins might interact simultaneously with both syntaxin regions. In search for a common mechanism, we now reinvestigated the Sly1/Sed5 interaction. We found that individual Sed5 adopts a tight closed conformation. Sly1 binds to both the closed conformation and the N-peptide of Sed5, suggesting that this is the original binding mode of SM proteins and syntaxins. In contrast to Munc18, however, Sly1 facilitates SNARE complex formation by loosening the closed conformation of Sed5.Universität Göttingen. Graduate School for Neurosciences and Molecular Biosciences (Fellowship
Search for quark contact interactions and extra spatial dimensions using dijet angular distributions in proton–proton collisions at √s = 8 TeV

A search is presented for quark contact interactions and extra spatial dimensions in proton–proton collisions at √s = 8 TeV using dijet angular distributions. The search is based on a data set corresponding to an integrated luminosity of 19.7 fb[superscript −1] collected by the CMS detector at the CERN LHC. Dijet angular distributions are found to be in agreement with the perturbative QCD predictions that include electroweak corrections. Limits on the contact interaction scale from a variety of models at next-to-leading order in QCD corrections are obtained. A benchmark model in which only left-handed quarks participate is excluded up to a scale of 9.0 (11.7) TeV for destructive (constructive) interference at 95% confidence level. Lower limits between 5.9 and 8.4 TeV on the scale of virtual graviton exchange are extracted for the Arkani-Hamed–Dimopoulos–Dvali model of extra spatial dimensions.United States. Dept. of EnergyNational Science Foundation (U.S.
Copper(I)–Phosphinite Complexes in Click Cycloadditions: Three-Component Reactions and Preparation of 5-Iodotriazoles

The remarkable activity displayed by copper(I)–phosphinite complexes of general formula [CuBr(L)] in two challenging cycloadditions is reported: a) the one-pot azidonation/cycloaddition of boronic acids, NaN3, and terminal alkynes; b) the cycloaddition of azides and iodoalkynes. These air-stable catalysts led to very good results in both cases and the expected triazoles could be isolated in pure form under ‘Click-suitable’ conditions.This research was financially supported by Imperial College. The Royal Society (RG140579) and EPSRC (EP/K030760/1) are acknowledged for further funding. J. M. P. thanks the MICINN (Spain, FPI program, EEBB-I-14–08372) for an internship fellowship
Search for a standard model Higgs boson in the mass range 200-600 GeV in the H -> ZZ -> l(+)l(-) q q-bar decay channel with the ATLAS detector

A search for a heavy Standard Model Higgs boson decaying via View the MathML sourceH→ZZ→ℓ+ℓ−qq¯, where ℓ=eℓ=e or μ , is presented. The search uses a data set of pp collisions at View the MathML sources=7 TeV, corresponding to an integrated luminosity of 4.7 fb−14.7 fb−1 collected in 2011 by the ATLAS detector at the CERN LHC. No significant excess of events above the estimated background is found. Upper limits at 95% confidence level on the production cross section of a Higgs boson with a mass in the range between 200 and 600 GeV600 GeV are derived. A Standard Model Higgs boson with a mass in the range 300 GeV⩽mH⩽322 GeV300 GeV⩽mH⩽322 GeV or 353 GeV⩽mH⩽410 GeV353 GeV⩽mH⩽410 GeV is excluded at 95% CL. The corresponding expected exclusion range is 351 GeV⩽mH⩽404 GeV351 GeV⩽mH⩽404 GeV at 95% CL.ATLAS Collaboratio
Precision diabetes: learning from monogenic diabetes.

The precision medicine approach of tailoring treatment to the individual characteristics of each patient or subgroup has been a great success in monogenic diabetes subtypes, MODY and neonatal diabetes. This review examines what has led to the success of a precision medicine approach in monogenic diabetes (precision diabetes) and outlines possible implications for type 2 diabetes. For monogenic diabetes, the molecular genetics can define discrete aetiological subtypes that have profound implications on diabetes treatment and can predict future development of associated clinical features, allowing early preventative or supportive treatment. In contrast, type 2 diabetes has overlapping polygenic susceptibility and underlying aetiologies, making it difficult to define discrete clinical subtypes with a dramatic implication for treatment. The implementation of precision medicine in neonatal diabetes was simple and rapid as it was based on single clinical criteria (diagnosed <6 months of age). In contrast, in MODY it was more complex and slow because of the lack of single criteria to identify patients, but it was greatly assisted by the development of a diagnostic probability calculator and associated smartphone app. Experience in monogenic diabetes suggests that successful adoption of a precision diabetes approach in type 2 diabetes will require simple, quick, easily accessible stratification that is based on a combination of routine clinical data, rather than relying on newer technologies. Analysing existing clinical data from routine clinical practice and trials may provide early success for precision medicine in type 2 diabetes
Grasping the past delay can improve visuomotor performance

Abstract“Optic ataxia” is caused by damage to the human posterior parietal cortex (PPC). It disrupts all components of a visually guided prehension movement, not only the transport of the hand toward an object's location [1], but also the in-flight finger movements pretailored to the metric properties of the object [2–4]. Like previous cases [4, 5], our patient (I.G.) was quite unable to open her handgrip appropriately when directly reaching out to pick up objects of different sizes. When first tested, she failed to do this even when she had previewed the target object 5 s earlier. Yet despite this deficit in “real” grasping, we found, counterintuitively, that I.G. showed good grip scaling when “pantomiming” a grasp for an object seen earlier but no longer present. We then found that, after practice, I.G. became able to scale her handgrip when grasping a real target object that she had previewed earlier. By interposing catch trials in which a different object was covertly substituted for the original object during the delay between preview and grasp, we found that I.G. was now using memorized visual information to calibrate her real grasping movements. These results provide new evidence that “off-line” visuomotor guidance can be provided by networks independent of the PPC
Testing No-Scale F–SU(5): A 125 GeV Higgs boson and SUSY at the s=8 TeV LHC

AbstractWe celebrate the recent Higgs discovery announcement with our experimental colleagues at the LHC and look forward to the implications that this success will bring to bear upon the continuing search for supersymmetry (SUSY). The model framework named No-Scale F–SU(5) possesses the rather unique capacity to provide a light CP-even Higgs boson mass in the favored 124–126 GeV window while simultaneously retaining a testably light SUSY spectrum that is consistent with emerging low-statistics excesses beyond the Standard Model expectation in the ATLAS and CMS multijet data. In this Letter we review the distinctive F–SU(5) mechanism that forges the physical 125 GeV Higgs boson and make a specific assessment of the ATLAS multijet SUSY search observables that may be expected for a 15 fb−1 delivery of 8 TeV data in this model context. Based on our Monte Carlo study, we anticipate that the enticing hints of a SUSY signal observed in the 7 TeV data could be amplified in the 8 TeV results. Moreover, if the existing signal is indeed legitimate, we project that the rendered gains in significance will be sufficient to conclusively rule out an alternative attribution to statistical fluctuation at that juncture
Association of T-Zone Reticular Networks and Conduits with Ectopic Lymphoid Tissues in Mice and Humans

Ectopic or tertiary lymphoid tissues (TLTs) are often induced at sites of chronic inflammation. They typically contain various hematopoietic cell types, high endothelial venules, and follicular dendritic cells; and are organized in lymph node–like structures. Although fibroblastic stromal cells may play a role in TLT induction and persistence, they have remained poorly defined. Herein, we report that TLTs arising during inflammation in mice and humans in a variety of tissues (eg, pancreas, kidney, liver, and salivary gland) contain stromal cell networks consisting of podoplanin+ T-zone fibroblastic reticular cells (TRCs), distinct from follicular dendritic cells. Similar to lymph nodes, TRCs were present throughout T-cell–rich areas and had dendritic cells associated with them. They expressed lymphotoxin (LT) β receptor (LTβR), produced CCL21, and formed a functional conduit system. In rat insulin promoter–CXCL13–transgenic pancreas, the maintenance of TRC networks and conduits was partially dependent on LTβR and on lymphoid tissue inducer cells expressing LTβR ligands. In conclusion, TRCs and conduits are hallmarks of secondary lymphoid organs and of well-developed TLTs, in both mice and humans, and are likely to act as important scaffold and organizer cells of the T-cell–rich zone
Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

SummaryOncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been implicated in regulating several myeloid and lymphoid malignancies, how precisely Stat5 regulates leukemogenesis, including its nuclear translocation to induce gene transcription, is poorly understood. In leukemic cells, we show constitutive activation of focal adhesion kinase (FAK) whose inhibition represses leukemogenesis. Downstream of FAK, activation of Rac1 is regulated by RacGEF Tiam1, whose inhibition prolongs the survival of leukemic mice. Inhibition of the Rac1 effector PAK1 prolongs the survival of leukemic mice in part by inhibiting the nuclear translocation of Stat5. These results reveal a leukemic pathway involving FAK/Tiam1/Rac1/PAK1 and demonstrate an essential role for these signaling molecules in regulating the nuclear translocation of Stat5 in leukemogenesis
UV and IR divergences within Dimensional Regularization in Non-Commutative theories and phenomenological implications

AbstractUsing Dimensional Regularization (DR) for some two-point functions of a prototype Non-Commutative (NC) φ4 scalar theory in 4 dimensions, we explicitly analyze, to one-loop, the IR and UV divergences of non-planar diagrams having quadratic divergences and compare to the case of the Pauli–Villars cut-off regularization (PVR). We also note that the IR structure 1/p∘p obtained from DR is reproduced by PVR in the limit where the UV cut-off Λ is set to infinity. We study the phenomenological implications of this result by rederiving bounds from low-energy data on the violation of Lorentz invariance based on the existence of the quadratic divergence. The most stringent (and regularization independent) bound on Lorentz violation from low-energy data is 1/θ≈ν⩾1015 GeV for NCQCD and 1010 GeV for NCQED, which comes from the absence of sidereal variations between the Cs and Hg atomic clocks
Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance

Mutations and polymorphisms in the gene-encoding factor H (CFH) are associated with atypical hemolytic uremic syndrome, dense deposit disease, and age-related macular degeneration. Many of these CFH genetic variations disrupt the regulatory role of factor H, supporting the concept that dysregulation of complement is a unifying pathogenic feature of these disorders. Evidence of a causal relationship with the disease is, however, not available for all CFH genetic variations found in patients, which is a potential cause of misinterpretations with important consequences for the patients and their relatives. CFH I890 and L1007 are two genetic variations repeatedly associated with atypical hemolytic uremic syndrome and also found in patients with dense deposit disease and age-related macular degeneration. Here we report an extensive genetic and functional analysis of these CFH variants. Our results indicate that I890 and L1007 segregate together as part of a distinct and relatively infrequent CFH haplotype in Caucasians. Extensive analysis of the S890/V1007 (control) and I890/L1007 (disease-associated) factor H protein variants failed to provide evidence that these amino acid changes have functional implications. Thus, the presence of the I890 and L1007 variants in healthy individuals and their high frequency in sub-Saharan African and African-American populations strongly suggest that I890 and L1007 are rare factor H polymorphisms unrelated to disease
The visual strategy specific to humans among hominids: A study using the gap–overlap paradigm

AbstractAlthough an extensive body of literature exists on the cognitive underpinnings of gaze movements in macaques and humans, few studies have investigated this topic from a broader evolutionary perspective. This study used the gap–overlap paradigm to examine the timing of the gaze movements by four hominid species: humans, chimpanzees, gorillas, and orangutans. The saccade latency involved in shifting the gaze from central to peripheral stimuli was measured and compared under two conditions, gap and overlap. The central stimulus disappeared shortly before the onset of the peripheral stimulus under the gap condition, but it remained under the overlap condition. Although all species demonstrated similar saccade latencies under the gap condition, the species clearly differed from one another under the overlap condition, which may suggest their similar perceptual and motor mechanism of making a saccade on the one hand and their differential strategies for coping with the competition between two activities involving fixation and initiation of a saccade (i.e. central vs. peripheral visual stimuli) on the other hand. In particular, humans showed longer saccade latency under the overlap condition compared to the other great apes, which may reflect this species’ unique means of visual processing
Thermodynamics of static dyonic AdS black holes in the ω-deformed Kaluza–Klein gauged supergravity theory

AbstractWe study thermodynamical properties of static dyonic AdS black holes in four-dimensional ω-deformed Kaluza–Klein gauged supergravity theory, and find that the differential first law requires a modification via introducing a new pair of thermodynamical conjugate variables (X,Y). To ensure such a modification, we then apply the quasi-local ADT formalism developed in Kim et al. (2013) [20] to calculate the quasi-local conserved charge and identify that the new pair is precisely the one previously introduced to modify the differential form of the first law
Friedmann equations of FRW universe in scalar–tensor gravity, f(R) gravity and first law of thermodynamics

AbstractIn the paper, [R.G. Cai, S.P. Kim, JHEP 0502 (2005) 050, hep-th/0501055], it is shown that by applying the first law of thermodynamics to the apparent horizon of an FRW universe and assuming the geometric entropy given by a quarter of the apparent horizon area, one can derive the Friedmann equations describing the dynamics of the universe with any spatial curvature; using the entropy formula for the static spherically symmetric black holes in Gauss–Bonnet gravity and in more general Lovelock gravity, where the entropy is not proportional to the horizon area, one can also obtain the corresponding Friedmann equations in each gravity. In this Letter we extend the study of the above mentioned paper to the cases of scalar–tensor gravity and f(R) gravity, and discuss the implication of results
Project Management Success I-C-E Model – A Work in Progress

AbstractProject management in software development has shown high rates of failure since the beginning of computation. Over the last years, several studies have sought and proposed solutions for this problem by focusing, for instance, on success critical aspects and evaluation criteria. Although these efforts have provided a significant evolution in how the work is done, project management success rates are in fact still well below the desirable values. This paper presents a work-in-progress based on an integrated approach to project management success and proposes a model that considers jointly the set of success influencers, project characteristics and evaluation criteria of success, from the initiation of a project until its closure
Measurement of the effective Bs0→J/ψKS0 lifetime

AbstractThis paper reports the first measurement of the effective Bs0→J/ψKS0 lifetime and an updated measurement of its time-integrated branching fraction. Both measurements are performed with a data sample, corresponding to an integrated luminosity of 1.0 fb−1 of pp collisions, recorded by the LHCb experiment in 2011 at a centre-of-mass energy of 7 TeV. The results are: τJ/ψKS0eff=1.75±0.12(stat)±0.07(syst) ps and B(Bs0→J/ψKS0)=(1.97±0.23)×10−5. For the latter measurement, the uncertainty includes both statistical and systematic sources
OpenAIRE Guidelines for CRIS Managers: Supporting Interoperability of Open Research Information through Established Standards

AbstractOpenAIRE is the European infrastructure enabling researchers to comply with the European Union requirements for Open Access to research results. OpenAIRE collects metadata from data sources across Europe and beyond and defines interoperability guidelines to assist providers in exposing their information in a way that is compatible with OpenAIRE. This contribution focuses on a specific type of data source, CRIS systems, and the respective OpenAIRE guidelines, based on CERIF XML. A range of issues, spanning different aspects of information representation and exchange, needed to be addressed by the guidelines in order to define a complete solution for interoperability
Theory of Mind and the Brain in Anorexia Nervosa: Relation to Treatment Outcome

ObjectiveConverging evidence suggests deficits in theory-of-mind (ToM) processing in patients with anorexia nervosa (AN). The present study aimed at elucidating the neural mechanisms underlying ToM-deficits in AN.MethodA total of 19 adolescent patients with AN and 21 age-matched controls were investigated using functional magnetic resonance imaging during performance of a ToM-task at two time points (in-patients: admission to hospital and discharge after weight recovery). Clinical outcomes in patients were determined 1 year after admission.ResultsIrrespective of the time point, AN patients showed reduced activation in middle and anterior temporal cortex and in the medial prefrontal cortex. Hypoactivation in the medial prefrontal cortex at admission to hospital (T1) was correlated with clinical outcome at follow-up.ConclusionsHypoactivation in the brain network supporting theory of mind may be associated with a social–cognitive endophenotype reflecting impairments of social functioning in anorexia nervosa which is predictive for a poor outcome at 1-year follow-up
Single- and multi-photon events with missing energy in e+e− collisions at LEP

AbstractSingle- and multi-photon events with missing energy are selected in 619 pb−1 of data collected by the L3 detector at LEP at centre-of-mass energies between 189 and 209 GeV. The cross sections of the process e+e−→νν̄γ(γ) are found to be in agreement with the Standard Model expectations, and the number of light neutrino species is determined, including lower energy data, to be Nν=2.98±0.05±0.04. Selection results are given in the form of tables which can be used to test future models involving single- and multi-photon signatures at LEP. These final states are also predicted by models with large extra dimensions and by several supersymmetric models. No evidence for such models is found. Among others, lower limits between 1.5 and 0.65 TeV are set, at 95% confidence level, on the new scale of gravity for the number of extra dimensions between 2 and 6