pinecone/core-2020-05-10-deduplication huggingface dataset:
The SK-N-AS human neuroblastoma cell line develops osteolytic bone metastases with increased angiogenesis and COX-2 expression

AbstractNeuroblastoma (NB), which arises from embryonic neural crest cells, is the most common extra-cranial solid tumor of childhood. Approximately half of NB patients manifest bone metastasis accompanied with bone pain, fractures and bone marrow failure, leading to disturbed quality of life and poor survival. To study the mechanism of bone metastasis of NB, we established an animal model in which intracardiac inoculation of the SK-N-AS human NB cells in nude mice developed osteolytic bone metastases with increased osteoclastogenesis. SK-N-AS cells induced the expression of receptor activator of NF-κB ligand and osteoclastogenesis in mouse bone marrow cells in the co-culture. SK-N-AS cells expressed COX-2 mRNA and produced substantial amounts of prostaglandin E2 (PGE2). In contrast, the SK-N-DZ and SK-N-FI human NB cells failed to develop bone metastases, induce osteoclastogenesis, express COX-2 mRNA and produce PGE2. Immunohistochemical examination of SK-N-AS bone metastasis and subcutaneous tumor showed strong expression of COX-2. The selective COX-2 inhibitor NS-398 inhibited PGE2 production and suppressed bone metastases with reduced osteoclastogenesis. NS-398 also inhibited subcutaneous SK-N-AS tumor development with decreased angiogenesis and vascular endothelial growth factor-A expression. Of interest, metastasis to the adrenal gland, a preferential site for NB development, was also diminished by NS-398. Our results suggest that COX2/PGE2 axis plays a critical role in the pathophysiology of osteolytic bone metastases and tumor development of the SK-NS-AS human NB. Inhibition of angiogenesis by suppressing COX-2/PGE2 may be an effective therapeutic approach for children with NB
Adults’ Education and Agricultural Innovation: A Social Learning Approach

AbstractSocial learning processes can be the basis of a method of agricultural innovation that involves expert and empirical knowledge. In this sense, the objective of this study was to determine the effectiveness and sustainability of an innovation process, understood as social learning, in a group of small farmers in the southern highlands of Peru. Innovative proposals and its permanence three years after the process finished were evaluated. It was observed that innovation processes generated are maintained over time; however, new innovations are not subsequently generated. We conclude that adult learning processes and innovation based on social learning are more effective and sustainable; however, the farmers internalization in innovation processes is given longer term
Endocytosis and early endosome motility in filamentous fungi

Hyphal growth of filamentous fungi requires microtubule-based long-distance motility of early endosomes. Since the discovery of this process in Ustilago maydis, our understanding of its molecular basis and biological function has greatly advanced. Studies in U. maydis and Aspergillus nidulans reveal a complex interplay of the motor proteins kinesin-3 and dynein, which co-operate to support bi-directional motion of early endosomes. Genetic screening has shed light on the molecular mechanisms underpinning motor regulation, revealing Hook protein as general motor adapters on early endosomes. Recently, fascinating insight into unexpected roles for endosome motility has emerged. This includes septin filament formation and cellular distribution of the machinery for protein translation
ASSERT – The Autism Symptom SElf-ReporT for adolescents and adults: Bifactor analysis and validation in a large adolescent population

AbstractWith a view to developing a brief screening instrument for autism symptoms in a general population of adolescents, seven items from the Asperger syndrome (and high-functioning autism) diagnostic interview were adapted for use as self-report in an online questionnaire for youths aged 16–19 years (N=10,220). The selected items target lack of social understanding (4 items) and rigid and repetitive behavior and interests (RRBI; 3 items). Factor analyses were performed, and the seven items were also validated against self-reported ASD diagnosis. Best statistical model fit was found for a bifactor model with one general factor and two domain specific factors tied to social difficulties and RRBI. Both the general and the domain specific factors were associated with self-reported ASD diagnoses. The scale (referred to as the Autism Symptom SElf-ReporT for Adolescents and Adults – ASSERT) had good screening properties with a receiver operating curve-area under the curve (ROC-AUC) of 0.87 and a diagnostic odds ratio (DOR) of 15.8. Applying a modified scoring of the scale further improved the screening properties leading to a ROC-AUC of 0.89 and a DOR of 24.9. The ASSERT holds promise as a brief self-report screen for autism symptoms in adolescents, and further studies should explore its usefulness for adults
Macromolecular Symmetric Assembly Prediction Using Swarm Intelligence Dynamic Modeling

SummaryProteins often assemble in multimeric complexes to perform a specific biologic function. However, trapping these high-order conformations is difficult experimentally. Therefore, predicting how proteins assemble using in silico techniques can be of great help. The size of the associated conformational space and the fact that proteins are intrinsically flexible structures make this optimization problem extremely challenging. Nonetheless, known experimental spatial restraints can guide the search process, contributing to model biologically relevant states. We present here a swarm intelligence optimization protocol able to predict the arrangement of protein symmetric assemblies by exploiting a limited amount of experimental restraints and steric interactions. Importantly, within this scheme the native flexibility of each protein subunit is taken into account as extracted from molecular dynamics (MD) simulations. We show that this is a key ingredient for the prediction of biologically functional assemblies when, upon oligomerization, subunits explore activated states undergoing significant conformational changes
Elliptic flow of muons from heavy-flavour hadron decays at forward rapidity in Pb–Pb collisions at sNN=2.76 TeV

AbstractThe elliptic flow, v2, of muons from heavy-flavour hadron decays at forward rapidity (2.5<y<4) is measured in Pb–Pb collisions at sNN=2.76 TeV with the ALICE detector at the LHC. The scalar product, two- and four-particle Q cumulants and Lee–Yang zeros methods are used. The dependence of the v2 of muons from heavy-flavour hadron decays on the collision centrality, in the range 0–40%, and on transverse momentum, pT, is studied in the interval 3<pT<10 GeV/c. A positive v2 is observed with the scalar product and two-particle Q cumulants in semi-central collisions (10–20% and 20–40% centrality classes) for the pT interval from 3 to about 5 GeV/c with a significance larger than 3σ, based on the combination of statistical and systematic uncertainties. The v2 magnitude tends to decrease towards more central collisions and with increasing pT. It becomes compatible with zero in the interval 6<pT<10 GeV/c. The results are compared to models describing the interaction of heavy quarks and open heavy-flavour hadrons with the high-density medium formed in high-energy heavy-ion collisions
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for reporting observational studies

AbstractMuch biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalisability. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included in an accurate and complete report of an observational study. We defined the scope of the recommendations to cover three main study designs: cohort, case–control, and cross-sectional studies. We convened a 2-day workshop in September 2004, with methodologists, researchers, and journal editors to draft a checklist of items. This list was subsequently revised during several meetings of the coordinating group and in e-mail discussions with the larger group of STROBE contributors, taking into account empirical evidence and methodological considerations. The workshop and the subsequent iterative process of consultation and revision resulted in a checklist of 22 items (the STROBE Statement) that relate to the title, abstract, introduction, methods, results, and discussion sections of articles. 18 items are common to all three study designs and four are specific for cohort, case–control, or cross-sectional studies. A detailed Explanation and Elaboration document is published separately and is freely available on the Web sites of PLoS Medicine, Annals of Internal Medicine, and Epidemiology. We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies
Effects of nuclear potential on the cumulants of net-proton and net-baryon multiplicity distributions in Au+Au collisions at sNN=5GeV

AbstractWe analyze the rapidity and transverse momentum dependence for the cumulants of the net-proton and net-baryon distributions in Au+Au collisions at sNN=5GeV with a microscopic hadronic transport (JAM) model. To study the effects of mean field potential and softening of equation of state (EoS) on the fluctuations of net-proton (baryon) in heavy-ion collisions, the calculations are performed with two different modes. The softening of EoS is realized in the model by implementing the attractive orbit in the two-body scattering to introduce a reduction pressure of the system. By comparing the results from the two modes with the results from default cascade, we find the mean field potential and softening of EoS have strong impacts on the rapidity distributions (dN/dy) and the shape of the net-proton (baryon) multiplicity distributions. The net-proton (baryon) cumulants and their ratios calculated from all of the three modes are with similar trends and show significant suppression with respect to unity, which can be explained by the presence of baryon number conservations. It indicates that the effects of mean field potential and softening of EoS might be not the ingredients that are responsible to the observed strong enhancement in the most central Au+Au collisions at 7.7 GeV measured by the STAR experiment at RHIC
Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage

AbstractPrimary cilia are slender, microtubule based structures found in the majority of cell types with one cilium per cell. In articular cartilage, primary cilia are required for chondrocyte mechanotransduction and the development of healthy tissue. Loss of primary cilia in Col2aCre;ift88fl/fl transgenic mice results in up-regulation of osteoarthritic (OA) markers and development of OA like cartilage with greater thickness and reduced mechanical stiffness. However no previous studies have examined whether loss of primary cilia influences the intrinsic mechanical properties of articular cartilage matrix in the form of the modulus or just the structural properties of the tissue. The present study describes a modified analytical model to derive the viscoelastic moduli based on previous experimental indentation data. Results show that the increased thickness of the articular cartilage in the Col2aCre;ift88fl/fl transgenic mice is associated with a reduction in both the instantaneous and equilibrium moduli at indentation strains of greater than 20%. This reveals that the loss of primary cilia causes a significant reduction in the mechanical properties of cartilage particularly in the deeper zones and possibly the underlying bone. This is consistent with histological analysis and confirms the importance of primary cilia in the development of a mechanically functional articular cartilage
The computational complexity of the parallel knock-out problem

AbstractWe consider computational complexity questions related to parallel knock-out schemes for graphs. In such schemes, in each round, each remaining vertex of a given graph eliminates exactly one of its neighbours. We show that the problem of whether, for a given bipartite graph, such a scheme can be found that eliminates every vertex is NP-complete. Moreover, we show that, for all fixed positive integers k≥2, the problem of whether a given bipartite graph admits a scheme in which all vertices are eliminated in at most (exactly) k rounds is NP-complete. For graphs with bounded tree-width, however, both of these problems are shown to be solvable in polynomial time. We also show that r-regular graphs with r≥1, factor-critical graphs and 1-tough graphs admit a scheme in which all vertices are eliminated in one round
Observation of the strange sea in the proton via inclusive φ-meson production in neutral current deep inelastic scattering at HERA

AbstractInclusive φ(1020)-meson production in neutral current deep inelastic e+p scattering has been measured with the ZEUS detector at HERA using an integrated luminosity of 45 pb−1. The φ mesons were studied in the range 10<Q2<100 GeV2, where Q2 is the virtuality of the exchanged photon, and in restricted kinematic regions in the transverse momentum, pT, pseudorapidity, η, and the scaled momentum in the Breit frame, xp. Monte Carlo models with the strangeness-suppression factor as determined by analyses of e+e− annihilation events overestimate the cross sections. A smaller value of the strangeness-suppression factor reduces the predicted cross sections, but fails to reproduce the shapes of the measured differential cross sections. High-momentum φ mesons in the current region of the Breit frame give the first direct evidence for the strange sea in the proton at low x
Skyrmions and pentaquarks in the quark–hadron continuity perspective

AbstractWe argue that in the color-flavor-locking (CFL) superconducting phase classical soliton solutions can exist, whose excitations should be interpreted as states formed by a quark (or an antiquark) and condensed diquarks. This finding extends the picture of quark–hadron continuity showing the existence of a region, intermediate between the CFL and the hypernuclear phase, where chiral solitons and Nambu–Goldstone bosons can exist. We derive an expression of the soliton mass in terms of the QCD coupling, gs, and the Nambu Goldstone boson parameters. From the quark–hadron continuity we can draw an argument in favor of the interpretation of the Θ+(1540) particle in terms of a strange antiquark and two highly correlated ud pairs (diquarks)
Paramedics' experiences of financial medicine practices in the pre-hospital environment. A pilot study

AbstractBackgroundThe term “financial medicine” refers to the delivery of health-related services where the generation of financial gain or “profit” takes precedence over the provision of care that is reflective of evidence-based best practice. The practicing of financial medicine includes over-servicing and overbilling, both of which have led to a sharp rise in the cost of health care and medical insurance in South Africa. For this reason, the practicing of financial medicine has been widely condemned both internationally and locally by the Health Professions Council of South Africa (HPCSA) and allied Professional bodies.ObjectivesThis qualitative pilot study explored and described the experiences of South African Paramedics with regard to the practicing of financial medicine in the local pre-hospital emergency care environment.MethodA sample of South African Paramedics were interviewed either face-to-face or telephonically. The interviews were audio recorded and transcripts produced. Content analysis was conducted to explore, document and describe the participants' experiences with regard to financial medicine practices in the local pre-hospital environment.ResultsIt emerged that all of the participants had experienced a number of financial medicine practices and associated unethical conduct. Examples included Over-servicing, Selective Patient Treatment, Fraudulent Billing Practices, Eliciting of kickbacks, incentives or benefits and Deliberate Time Wasting.ConclusionThe results of this study are concerning as the actions of service providers described by the participants constitute gross violations of the ethical and professional guidelines for health care professionals. The authors recommend additional studies be conducted to further explore these findings and to establish the reasons for, and ways of, limiting financial medicine practices in the South African emergency care environment
Eu3+ photoluminescence enhancement due to thermal energy transfer in Eu2O3-doped SiO2–B2O3–PbO2 glasses system

AbstractIn this work, Eu3+-doped lead borosilicate glasses (SiO2–B2O3–PbO2) synthesized by fusion method had their optical properties investigated as a function of temperature. Atomic Force Microscopy images obtained for a glass matrix annealed at 350 and 500°C show a precipitated crystalline phase with sizes 11 and 21nm, respectively. Besides, as the temperature increases from 350 to 300K a strong Eu3+ photoluminescence (PL) enhancement takes place. This anomalous feature is attributed to the thermally activated carrier transfer process from nanocrystals and charged intrinsic defects states to Eu3+ energy levels. In addition, the PL peaks in this temperature range were assigned to the Eu3+ transitions 5D0→7F2, at 612nm, 5D0→7F1, at 595nm, and 5D0→7F0, at 585nm. It was also observed that the 5D0→7F3 and 5D0→7F4 PL bands at 655 and 700nm, respectively, show a continuous decrease in intensity as the temperature increases
New solutions for the color–flavor locked strangelets

AbstractRecent publications rule out the negatively charged beta equilibrium strangelets in ordinary phase, and the color–flavor locked (CFL) strangelets are reported to be also positively charged. This Letter presents new solutions to the system equations where CFL strangelets are slightly negatively charged. If the ratio of the square-root bag constant to the gap parameter is smaller than 170 MeV, the CFL strangelets are more stable than iron and the normal unpaired strangelets. For the same parameters, however, the positively charged CFL strangelets are more stable
Unbroken B–L symmetry

AbstractThe difference between baryon number B and lepton number L is the only anomaly-free global symmetry of the Standard Model, easily promoted to a local symmetry by introducing three right-handed neutrinos, which automatically make neutrinos massive. The non-observation of any (B–L)-violating processes leads us to scrutinize the case of unbroken gauged B–L; besides Dirac neutrinos, the model contains only three parameters, the gauge coupling strength g′, the Stückelberg mass MZ′, and the kinetic mixing angle χ. The new force could manifest itself at any scale, and we collect and derive bounds on g′ over the entire testable range MZ′=0–1013 eV, also of interest for the more popular case of spontaneously broken B–L or other new light forces. We show in particular that successful Big Bang nucleosynthesis provides strong bounds for masses 10 eV<MZ′<10 GeV due to resonant enhancement of the rate f¯f↔ν¯RνR. The strongest limits typically arise from astrophysics and colliders, probing scales MZ′/g′ from TeV up to 1010 GeV
Some design considerations for polymer-free drug-eluting stents: A mathematical approach

AbstractIn this paper we provide the first model of drug elution from polymer-free arterial drug-eluting stents. The generalised model is capable of predicting drug release from a number of polymer-free systems including those that exhibit nanoporous, nanotubular and smooth surfaces. We derive analytical solutions which allow us to easily determine the important parameters that control drug release. Drug release profiles are provided, and we offer design recommendations so that the release profile may be tailored to achieve the desired outcome. The models presented here are not specific to drug-eluting stents and may also be applied to other biomedical implants that use nanoporous surfaces to release a drug
Kaluza–Klein gluon + jets associated production at the Large Hadron Collider

AbstractThe Kaluza–Klein excitations of gluons offer the exciting possibility of probing bulk Randall–Sundrum (RS) models. In these bulk models either a custodial symmetry or a deformation of the metric away from AdS is invoked in order to deal with electroweak precision tests. Addressing both these models, we suggest a new channel in which to study the production of KK-gluons (gKK): one where it is produced in association with one or more hard jets. The cross-section for the gKK + jets channel is significant because of several contributing sub-processes. In particular, the 1-jet and the 2-jet associated processes are important because at these orders in QCD the qg and the gg initial states respectively come into play. We have performed a hadron-level simulation of the signal and present strategies to effectively extract the signal from what could potentially be a huge background. We present results for the kinematic reach of the LHC Run-II for different gKK masses in bulk-RS models
Secular trends and factors associated with overweight among Brazilian preschool children: PNSN-1989, PNDS-1996, and 2006/07

AbstractObjectiveto describe the secular trends in overweight among preschool children in the years 1989, 1996, and 2006, and to identify risk factors associated with this condition in 2006.Methodsanthropometric data from three surveys (1989, 1996, and 2006) with a representative sample of the population were analyzed. Overweight was defined as the weight-for-height Z-score. The multivariable models of overweight association with risk factors were generated by Poisson regression, and the estimates were shown as prevalence ratios with their respective 95% confidence intervals (PR [95% CI]).Resultsthroughout the 17-year period studied, the relative prevalence of overweight in preschoolers increased by 160% in Brazil, representing an increase of 9.4% per year. Based on data from the National Survey on Demography and Health of Women and Children - 2006/07, four multivariable models were created (macro-environmental, maternal, individual, and final model) assuming hierarchy among the risk factors. In the final model, only the following remained associated with overweight: regions South/Southeast (1.55 [1.17 to 2.06]), middle-class (1.35 [1.02 to 1.77]), maternal obesity (1.66 [1.22 to 2.27]), birth weight ≥ 3.9kg (1.87 [1.31 to 2.67]), and being an only child or having only one sibling (1.81 [1.31 to 2.49]).Conclusionthe prevalence of overweight among preschool children in Brazil has increased dramatically over the past 17 years, and it was higher in the 1996-2006 period. Future strategies for prevention and control of overweight in public health should focus or intensify actions in communities that are characterized by the presence of the risks identified in the present study
The 〈VVA〉 correlator at three loops in perturbative QCD

AbstractIt is known that the correlator of one axial and two vector currents, that receives leading contributions through one-loop fermion triangle diagrams, is not modified by QCD radiative corrections at two loops. It was suggested that this non-renormalization of the 〈VVA〉 correlator persists in higher orders in perturbative QCD as well. To check this assertion, we compute the three-loop QCD corrections to the 〈VVA〉 correlator using the technique of asymptotic expansions. We find that these corrections do not vanish and that they are proportional to the QCD β-function