pinecone/core-2020-05-10-deduplication huggingface dataset:
Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities.

The intestinal microbiota is involved in many physiological processes and it is increasingly recognized that differences in community composition can influence the outcome of a variety of murine models used in biomedical research. In an effort to describe and account for the variation in intestinal microbiota composition across the animal facilities of participating members of the DFG Priority Program 1656 "Intestinal Microbiota", we performed a survey of C57BL/6J mice from 21 different mouse rooms/facilities located at 13 different institutions across Germany. Fresh feces was sampled from five mice per room/facility using standardized procedures, followed by extraction and 16S rRNA gene profiling (V1-V2 region, Illumina MiSeq) at both the DNA and RNA (reverse transcribed to cDNA) level. In order to determine the variables contributing to bacterial community differences, we collected detailed questionnaires of animal husbandry practices and incorporated this information into our analyses. We identified considerable variation in a number of descriptive aspects including the proportions of major phyla, alpha- and beta diversity, all of which displayed significant associations to specific aspects of husbandry. Salient findings include a reduction in alpha diversity with the use of irradiated chow, an increase in inter-individual variability (beta diversity) with respect to barrier access and open cages and an increase in bacterial community divergence with time since importing from a vendor. We further observe a high degree of facility-level individuality, which is likely due to each facility harboring its own unique combination of multiple varying attributes of animal husbandry. While it is important to account and control for such differences between facilities, the documentation of such diversity may also serve as a valuable future resource for investigating the origins of microbial-driven host phenotypes
Idealising mesh modelling for haptic enabled services and operands

Communicating the knowledge and science of product engineering, analysis and manufacturing planning is an area of continued research driven by the digital economy. Virtual Reality (VR) is a generally accepted interactive digital platform which industry and academia have used to model engineering workspaces. Interactive services that generate a sense of immersion, particularly the sense of touch to communicate shape modelling and manipulation, is increasingly being used in applications that range from Design For Manufacturing and Assembly (DFMA) and Process Planning (PP) to medical applications such as surgical planning and training. In simulation, the natural way for solid modelling is the use of primitive geometries, and combinations of them where complex shapes are required, to create, modify or manipulate models. However, this natural way makes use of Booleans operands that require large computational times which make them inappropriate for real time VR applications. This work presents an insight on new methods for haptic shape modelling focused on Boolean operands on a polygon mesh. This is not meant as a contrast to point/mesh-editing methods, instead it is focused on idealising polygonal mesh modelling and manipulation for use with haptics. The resulting models retain a high level of geometric detail for visualisation, modelling, manipulation and haptic rendering
CSI 2264: Simultaneous optical and infrared light curves of young disk-bearing stars in NGC 2264 with CoRoT and Spitzer-- evidence for multiple origins of variability

Anne Marie Cody, et al, 'CSI 2264: SIMULTANEOUS OPTICAL AND INFRARED LIGHT CURVES OF YOUNG DISK-BEARING STARS IN NGC 2264 WITH CoRoT and SPITZER???EVIDENCE FOR MULTIPLE ORIGINS OF VARIABILITY', The Astronomical Journal, 147:82 (47pp), 2014 April doi:10.1088/0004-6256/147/4/82 ?? 2014. The American Astronomical Society.We present the Coordinated Synoptic Investigation of NGC 2264, a continuous 30-day multi-wavelength photometric monitoring campaign on more than 1000 young cluster members using 16 telescopes. The unprecedented combination of multi-wavelength, high-precision, high-cadence, and long-duration data opens a new window into the time domain behavior of young stellar objects. Here we provide an overview of the observations, focusing on results from Spitzer and CoRoT. The highlight of this work is detailed analysis of 162 classical T Tauri stars for which we can probe optical and mid-infrared flux variations to 1% amplitudes and sub-hour timescales. We present a morphological variability census and then use metrics of periodicity, stochasticity, and symmetry to statistically separate the light curves into seven distinct classes, which we suggest represent different physical processes and geometric effects. We provide distributions of the characteristic timescales and amplitudes, and assess the fractional representation within each class. The largest category (>20%) are optical "dippers" having discrete fading events lasting ~1-5 days. The degree of correlation between the optical and infrared light curves is positive but weak; notably, the independently assigned optical and infrared morphology classes tend to be different for the same object. Assessment of flux variation behavior with respect to (circum)stellar properties reveals correlations of variability parameters with H$\alpha$ emission and with effective temperature. Overall, our results point to multiple origins of young star variability, including circumstellar obscuration events, hot spots on the star and/or disk, accretion bursts, and rapid structural changes in the inner disk
Detailed petrophysical and geophysical characterization of core samples from the potential caprock-reservoir system in the Sulcis Coal Basin (Southwestern Sardinia - Italy)

In this work we present a methodology suitable to identify a caprock-reservoir system for the CO2 storage in the Sulcis Coal Basin (SW Sardinia - Italy). The petrophysical and geophysical characterizations indicate that the potential carbonate reservoir ("Miliolitico" Fm. Auct.) located at the base of the Eocene stratigraphic sequence in the mining district of the Sulcis Coal Basin, southwestern Sardinia, is heterogeneous but presents suitable reservoir zones for the storage of the CO2. The GPS data analysis indicates that the study area is stable, since it is characterized by a surface crustal deformation smaller than 1 mm/y
Process improvement for small firms: an evaluation of the RAPID assessment-based method

With increasing interest by the software development community in software process improvement (SPI), it is vital that SPI programs are evaluated and the reports of lessons learned disseminated.  This paper presents an evaluation of a program in which low-rigour, one-day SPI assessments were offered at no cost to 22 small Australian software development firms.  The assessment model was based on ISO/IEC 15504 (SPICE).  About twelve months after the assessment, the firms were contacted to arrange a follow-up meeting to determine the extent to which they had implemented the recommendations from the assessment.  \ud
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Comparison of the process capability levels at the time of assessment and the follow-up meetings revealed that the process improvement program was effective in improving the process capability of 15 of these small software development firms.  Analysis of the assessment and follow-up reports explored important issues relating to SPI: elapsed time from assessment to follow-up meeting, the need for mentoring, the readiness of firms for SPI, the role of the owner/manager, the advice provided by the assessors, and the need to record costs and benefits.  Based on an analysis of the program and its outcomes, firms are warned not to undertake SPI if their operation is likely to be disrupted by events internal to the firm or in the external environment.  Firms are urged to draw on the expertise of assessors and consultants as mentors, and to ensure the action plan from the assessment is feasible in terms of the timeframe for evaluation.  The RAPID method can be improved by fostering a closer relationship between the assessor and the firm sponsor; by making more extensive use of feedback questionnaires after the assessment and follow-up meeting; by facilitating the collection and reporting of cost benefit metrics; and by providing more detailed guidance for the follow-up meeting.  \ud
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As well as providing an evaluation of the assessment model and method, the outcomes from this research have the potential to better equip practitioners and consultants to undertake software process improvement, hence increasing the success of small software development firms in domestic and global markets.\u
Query-based Verification of Biochemical Oscillations through Probabilistic Model Checking

Automated verification of stochastic models has been proved to be an effective technique for the analysis of a large class of stochastically behaving systems. In this paper we show how stochastic modelchecking can be effectively applied to the analysis of biological systems. We consider a few models of biological systems taken from the literature, and we consider both their encodings as ordinary differential equations and Markovian models. We show that stochastic model-checking verification of biological systems can complement both deterministic and stochastic simulation techniques when dealing with dynamical properties of oscillators. We demonstrate how stochastic model-checking can provide exact quantitative characterization of properties of systems exhibiting oscillatory behavior, providing insights that cannot be obtained with differential equations models and that would require a large number of runs with stochastic simulation approaches. This is the preliminary version of a paper that was published in the Proceedings of the International Workshop From Biology To Concurrency and back (FBTC 2008), satellite workshop of ICALP 2008, July 12, 2008, Reykjavik, Iceland, ENTCS 194(3). The original publication is available at DOI:10.1016/j.entcs.2009.02.00
“Brand” and performance in a new environment: Analysis of the law school market in Japan

Using Japanese panel data for 2006-2009, this study attempts to examine how the pass rate of law school students taking the new bar examination influences the number of applicants for the law school in the following years. The major finding is that the higher the law school student pass rate, the greater the number of applicants for the law school becomes. Furthermore, the positive effect of the pass rate is larger for a prestigious university’s law school than for other schools. It follows that the “brand” and the school’s current performance are complementary in increasing demand for places in the law school.
Theory and Empirics of Stage-Dependent Intellectual Property Rights

Inspired by the Chinese experience, we develop a Schumpeterian growth model of distance to frontier in which economic growth in the developing country is driven by domestic innovation as well as imitation and transfer of foreign technologies through foreign direct investment. We show that optimal intellectual property rights (IPR) protection is stage-dependent. At an early stage of development, the country implements weak IPR protection to facilitate imitation. At a later stage of development, the country implements strong IPR protection to encourage domestic innovation. Therefore, the growth-maximizing and welfare-maximizing levels of patent strength increase as the country evolves towards the world technology frontier, and this dynamic pattern is consistent with the actual evolution of patent strength in China. Furthermore, we use a dynamic panel regression model to provide empirical evidence that supports the key implication of our theoretical model.
Determination of the Thickness of Al2O3 Barriers in Magnetic Tunnel Junctions

Copyright © 2002 American Institute of PhysicsThe barrier thickness in magnetic spin-dependent tunnel junctions with Al2O3 barriers has been measured using grazing incidence x-ray reflectivity and by fitting the tunneling current to the Simmons model. We have studied the effect of glow discharge oxidation time on the barrier structure, revealing a substantial increase in Al2O3 thickness with oxidation. The greater thickness of barrier measured using grazing incidence x-ray reflectivity compared with that obtained by fitting current density–voltage to the Simmons electron tunneling model suggests that electron tunneling is localized to specific regions across the barrier, where the thickness is reduced by fluctuations due to nonconformal roughness
Searches for supersymmetry with the ATLAS detector using final states with two leptons and missing transverse momentum in root s=7 TeV proton-proton collisions

Results of three searches are presented for the production of supersymmetric particles decaying into final states with missing transverse momentum and exactly two isolated leptons, e or μ  . The analysis uses a data sample collected during the first half of 2011 that corresponds to a total integrated luminosity of 1 fb−11 fb−1 of View the MathML sources=7 TeV proton–proton collisions recorded with the ATLAS detector at the Large Hadron Collider. Opposite-sign and same-sign dilepton events are separately studied, with no deviations from the Standard Model expectation observed. Additionally, in opposite-sign events, a search is made for an excess of same-flavour over different-flavour lepton pairs. Effective production cross sections in excess of 9.9 fb for opposite-sign events containing supersymmetric particles with missing transverse momentum greater than 250 GeV are excluded at 95% CL. For same-sign events containing supersymmetric particles with missing transverse momentum greater than 100 GeV, effective production cross sections in excess of 14.8 fb are excluded at 95% CL. The latter limit is interpreted in a simplified electroweak gaugino production model excluding chargino masses up to 200 GeV, under the assumption that slepton decay is dominant.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; ARTEMIS, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNAS, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT, Greece; ISF, MINERVA, GIF, DIP and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America.info:eu-repo/semantics/publishedVersio
Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study

Ketoprofen (3-benzoyl-alpha-methylbenzeneacetic acid) is a widely used nonsteroidal anti-inflammatory drug (NSAID), always administered in the form of drug-excipient physical mixtures (PMs). The occurrence of possible interactions between ketoprofen and two commonly used excipients-lactose (LAC) and polyvinylpyrrolidone (PVP)-was evaluated, through vibrational spectroscopy techniques [both Raman and Inelastic Neutron Scattering (INS)]. Spectral evidence of drug:excipient close contacts, which were enhanced by aging, was verified for the (1:1) (w:w) (ketoprofen:PVP) and (ketoprofen:LAC) PMs, both by Raman and INS. These interactions were found to involve mainly the central carbonyl and the terminal methyl-carboxylic moieties of the ketoprofen molecule, this being reflected in particular vibrational modes, such as the methyl torsion, the out-of-plane C-OH bending, and the inter-ring C=O stretching
Squashed, magnetized black holes in D=5 minimal gauged supergravity

We construct a new class of black hole solutions in five-dimensional Einstein-Maxwell-Chern-Simons theory with a negative cosmological constant. These configurations are cohomogeneity-1, with two equal-magnitude angular momenta. In the generic case, they possess a non-vanishing magnetic potential at infinity with a boundary metric which is the product of time and a squashed three-dimensional sphere. Both extremal and non-extremal black holes are studied. The non-extremal black holes satisfying a certain relation between electric charge, angular momenta and magnitude of the magnetic potential at infinity do not trivialize in the limit of vanishing event horizon size, becoming particle-like (non-topological) solitonic configurations. Among the extremal black holes, we show the existence of a new one-parameter family of supersymmetric solutions, which bifurcate from a critical Gutowski-Reall configuration
Earthquake Disaster Risk Reduction in Iran: Lessons and ‘‘Lessons Learned’’ from Three Large Earthquake Disasters—Tabas 1978, Rudbar 1990, and Bam 2003

-This article addresses three large earthquake disasters in Iran: Tabas in 1978, Rudbar in 1990, and Bam in 2003. Lessons and "Lessons Learned" from these three earthquake disasters were investigated together with their contributions over time towards earthquake disaster risk reduction in Iran. Many lessons from 1978 Tabas, 1990 Rudbar, and 2003 Bam did not become "Lessons Learned" and they were identified again within the dramatic context of other earthquake disasters in various places of Iran. Both lessons and "Lessons Learned" from Tabas, Rudbar, Bam, and other earthquake disasters in Iran require a sustainable long-term framework-an earthquake culture
MHV diagrams in momentum twistor space.

We show that there are remarkable simplifications when the MHV diagram formalism for   N=4  super Yang-Mills is reformulated in momentum twistor space. The vertices are replaced by unity while each propagator becomes a dual superconformal ‘R-invariant’ whose arguments may be read off from the diagram, and include an arbitrarily chosen reference twistor. The momentum twistor MHV rules generate a formula for the full, all-loop planar integrand for the super Yang-Mills S-matrix that is manifestly dual superconformally invariant up to the choice of a reference twistor. We give a general proof of this reformulation and illustrate its use by computing the momentum twistor NMHV and N2MHV tree amplitudes and the integrands of the MHV and NMHV 1-loop and the MHV 2-loop planar amplitudes
Winning versus losing during gambling and its neural correlates

Humans often make decisions which maximize an internal utility function. For example, humans often maximize their expected reward when gambling and this is considered as a “rational” decision. However, humans tend to change their betting strategies depending on how they “feel”. If someone has experienced a losing streak, they may “feel” that they are more likely to win on the next hand even though the odds of the game have not changed. That is, their decisions are driven by their emotional state. In this paper, we investigate how the human brain responds to wins and losses during gambling. Using a combination of local field potential recordings in human subjects performing a financial decision-making task, spectral analyses, and non-parametric cluster statistics, we investigated whether neural responses in different cognitive and limbic brain areas differ between wins and losses after decisions are made. In eleven subjects, the neural activity modulated significantly between win and loss trials in one brain region: the anterior insula (p = 0.01). In particular, gamma activity (30-70 Hz) increased in the anterior insula when subjects just realized that they won. Modulation of metabolic activity in the anterior insula has been observed previously in functional magnetic resonance imaging studies during decision making and when emotions are elicited. However, our study is able to characterize temporal dynamics of electrical activity in this brain region at the millisecond resolution while decisions are made and after outcomes are revealed.Peer reviewe
The biology of PGC-1α and its therapeutic potential

In eukaryotes, cellular and systemic metabolism is primarily controlled by mitochondrial activity. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is an important regulator of mitochondrial biogenesis and function. Furthermore, PGC-1α controls many of the phenotypic adaptations of oxidative tissues to external and internal perturbations. By contrast, dysregulated metabolic plasticity is involved in the etiology of numerous diseases. Accordingly, modulation of PGC-1α levels and activity has recently been proposed as a therapeutic option for several pathologies. However, pharmacological interventions aimed at PGC-1α have to overcome inherent limitations of targeting a coactivator protein. Here, I focus on the recent breakthroughs in the identification of physiological and pathophysiological contexts involving PGC-1α. In addition, perspectives regarding the therapeutic importance of PGC-1α-controlled cellular and systemic metabolism are outlined
The conflict mitigating effects of trade in the India-Pakistan case

Abstract
We examine whether greater inter-state trade, democracy and reduced military spending lower belligerence between India and Pakistan, beginning with a theoretical model covering the opportunity costs of conflict in terms of trade losses and security spending, as well as the costs of making concessions to rivals. Conflict between the two nations is best understood in a multivariate framework where variables such as economic performance, integration with rest of the world, bilateral trade,
military expenditure, democracy orientation and population are simultaneously considered.
Our empirical investigation based on time series econometrics from 1950 to 2005 suggests that reduced bilateral trade, greater military expenditure, less development expenditure, lower levels of democracy, lower growth rates and less general trade openness are all conflict enhancing. Globalization, or a greater openness to international trade with the rest of the world, is the most significant driver of a liberal peace, rather than a common democratic orientation