pinecone/core-2020-05-10-deduplication huggingface dataset:
Classroom-based cognitive behaviour therapy (FRIENDS):A cluster randomised controlled trial to prevent anxiety in children through education in shools (PACES)

Anxiety in children is common, impairs everyday functioning, and increases the risk of severe mental health disorders in adulthood. We investigated the effect of a classroom-based cognitive behaviour therapy prevention programme (FRIENDS) on anxiety symptoms in children. Methods: Preventing Anxiety in Children though Education in Schools (PACES) is a three-group parallel cluster randomised controlled trial. Interventions were given between September, 2011, and July, 2012, with schools as the unit of allocation and individual participants as the unit of analysis. We enrolled state-funded junior schools in southwest England. We sent information to all eligible schools (state-funded junior schools in southwest England) inviting them to enrol in the study. School year groups were assigned by computer-generated randomisation (1:1:1) to receive either school-led FRIENDS (led by teacher or school staff member), health-led FRIENDS (led by two trained health facilitators), or usual school provision. Children were not masked to treatment allocation. The allocated programme was given to all students (aged 9-10 years) in the school year (ie, universal delivery) as part of the school curriculum as nine, 60 min weekly sessions. Outcomes were collected by self-completed questionnaire administered by researchers masked to allocation. Primary outcome was symptoms of anxiety and low mood at 12 months assessed by the Revised Child Anxiety and Depression Scale (RCADS 30). Analyses were intention to treat and accounted for the clustered nature of the design. The study is registered, number ISRCTN23563048. Findings: 45 schools were enrolled: 14 (n=497 children) were randomly assigned to school-led FRIENDS, 14 (n=509) to health-led FRIENDS, and 12 (n=442) to usual school provision. 1257 (92%) children completed 12 month assessments (449 in health-led FRIENDS, 436 in school-led FRIENDS, and 372 in usual school provision). We recorded a difference at 12 months in adjusted mean child-reported RCADS scores for health-led versus school-led FRIENDS (19·49 [SD 14·81] vs 22·86 [15·24]; adjusted difference -3·91, 95% CI -6·48 to -1·35; p=0·0004) and health-led FRIENDS versus usual school provision (19·49 [14·81] vs 22·48 [15·74]; -2·66, -5·22 to -0·09; p=0·043). We noted no differences in parent or teacher ratings. Training teachers to deliver mental health programmes was not as effective as delivery by health professionals. Interpretation: Universally delivered anxiety prevention programmes can be effective when used in schools. However, programme effectiveness varies depending on who delivers them. Funding: National Institute for Health Research Public Health Research Programme
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder
Transcriptional role of p53 in interferon-mediated antiviral immunity.

Tumor suppressor p53 is activated by several stimuli, including DNA damage and oncogenic stress. Previous studies (Takaoka, A., S. Hayakawa, H. Yanai, D. Stoiber, H. Negishi, H. Kikuchi, S. Sasaki, K. Imai, T. Shibue, K. Honda, and T. Taniguchi. 2003. Nature. 424:516-523) have shown that p53 is also induced in response to viral infections as a downstream transcriptional target of type I interferon (IFN) signaling. Moreover, many viruses, including SV40, human papillomavirus, Kaposi's sarcoma herpesvirus, adenoviruses, and even RNA viruses such as polioviruses, have evolved mechanisms designated to abrogate p53 responses. We describe a novel p53 function in the activation of the IFN pathway. We observed that infected mouse and human cells with functional p53 exhibited markedly decreased viral replication early after infection. This early inhibition of viral replication was mediated both in vitro and in vivo by a p53-dependent enhancement of IFN signaling, specifically the induction of genes containing IFN-stimulated response elements. Of note, p53 also contributed to an increase in IFN release from infected cells. We established that this p53-dependent enhancement of IFN signaling is dependent to a great extent on the ability of p53 to activate the transcription of IFN regulatory factor 9, a central component of the IFN-stimulated gene factor 3 complex. Our results demonstrate that p53 contributes to innate immunity by enhancing IFN-dependent antiviral activity independent of its functions as a proapoptotic and tumor suppressor gene.Peer-reviewedPublisher Version1398
THE OPTICALLY UNBIASED GRB HOST (TOUGH) SURVEY. VII. THE HOST GALAXY LUMINOSITY FUNCTION: PROBING THE RELATIONSHIP BETWEEN GRBs AND STAR FORMATION TO REDSHIFT ~ 6

Gamma-ray bursts (GRBs) offer a route to characterizing star-forming galaxies and quantifying high-z star formation that is distinct from the approach of traditional galaxy surveys: GRB selection is independent of dust and probes even the faintest galaxies which can evade detection in flux-limited surveys. However, the exact relation between the GRB rate and the star formation rate (SFR) throughout all redshifts is controversial. The Optically Unbiased GRB Host (TOUGH) survey includes observations of all GRB hosts (69) in an optically unbiased sample of Swift GRBs; we utilize these to constrain the evolution of the UV GRB-host-galaxy luminosity function (LF) between z = 0 and z = 4.5, and compare this with LFs derived from both Lyman-break galaxy (LBG) surveys and simulation modeling. At all redshifts we find the GRB hosts to be most consistent with an LF derived from SFR weighted models incorporating GRB production via both metallicity-dependent and independent channels with a relatively high level of bias toward low metallicity hosts. In the range 1 < z < 3 an SFR weighted LBG derived (i.e., non-metallicity biased) LF is also a reasonable fit to the data. Between z ~ 3 and z ~ 6, we observe an apparent lack of UV bright hosts in comparison with LBGs, though the significance of this shortfall is limited by nine hosts of unknown redshift.Peer-reviewedPublisher Versio
Review: the predictability of the extra-tropical stratosphere on monthly timescales and its impact on the skill of tropospheric forecasts

Extreme variability of the winter- and spring-time stratospheric polar vortex has been shown to affect\ud
extratropical tropospheric weather. Therefore, reducing stratospheric forecast error may be one way to improve\ud
the skill of tropospheric weather forecasts. In this review, the basis for this idea is examined. A range of studies of different stratospheric extreme vortex events shows that they can be skilfully forecasted beyond five days and into the sub-seasonal range (0-30 days) in some cases. Separate studies show that typical errors in forecasting a stratospheric extreme vortex event can alter tropospheric forecasts skill by 5-7% in the extratropics on sub-seasonal timescales. Thus understanding what limits stratospheric predictability is of significant interest to\ud
operational forecasting centres. Both limitations in forecasting tropospheric planetary waves and stratospheric\ud
model biases have been shown to be important in this context
Topological black holes in ${\mathfrak {su}}(N)$ Einstein-Yang-Mills
  theory with a negative cosmological constant

We investigate the phase space of topological black hole solutions of
${\mathfrak {su}}(N)$ Einstein-Yang-Mills theory in anti-de Sitter space with a
purely magnetic gauge potential. The gauge field is described by $N-1$ magnetic
gauge field functions $\omega_{j}$, $j=1,\ldots , N-1$. For ${\mathfrak
{su}}(2)$ gauge group, the function $\omega_{1}$ has no zeros. This is no
longer the case when we consider a larger gauge group. The phase space of
topological black holes is considerably simpler than for the corresponding
spherically symmetric black holes, but for $N>2$ and a flat event horizon,
there exist solutions where at least one of the $\omega_{j}$ functions has one
or more zeros. For most of the solutions, all the $\omega_{j}$ functions have
no zeros, and at least some of these are linearly stable.Comment: 7 pages, 3 figures, minor changes, references added, matches
  published versio
An Exact Factorization Perspective on Quantum Interferences in
  Nonadiabatic Dynamics

Nonadiabatic quantum interferences emerge whenever nuclear wavefunctions in
different electronic states meet and interact in a nonadiabatic region. In this
work, we analyze how nonadiabatic quantum interferences translate in the
context of the exact factorization of the molecular wavefunction. In
particular, we focus our attention on the shape of the time-dependent potential
energy surface - the exact surface on which the nuclear dynamics takes place.
We use a one-dimensional exactly-solvable model to reproduce different
conditions for quantum interferences, whose characteristic features already
appear in one-dimension. The time-dependent potential energy surface develops
complex features when strong interferences are present, in clear contrast to
the observed behavior in simple nonadiabatic crossing cases. Nevertheless,
independent classical trajectories propagated on the exact time-dependent
potential energy surface reasonably conserve a distribution in configuration
space that mimics the one of the exact nuclear probability density.Comment: Accepted in J. Chem. Phy
Electronic topological transitions in Nb$_3$X (X = Al, Ga, In, Ge and
  Sn) under compression investigated by first principles calculations

First principles electronic structure calculations of A-15 type Nb$_3$X (X =
Al, Ga, In, Ge and Sn) compounds are performed at ambient and high pressures.
Mechanical stability is confirmed in all the compounds both at ambient as well
as under compression from the calculated elastic constants. We have observed
four holes and two electron Fermi surfaces (FS) for all the compounds studied
and FS nesting feature is observed at M and along X - $\Gamma$ in all the
compounds. A continuous change in the FS topology is observed under pressure in
all the compounds which is also reflected in the calculated elastic constants
and density of states under pressure indicating the Electronic topological
transitions (ETT). The ETT observed at around 21.5 GPa, 17.5 GPa in Nb$_3$Al
and Nb$_3$Ga are in good agreement with the anomalies observed by the
experiments.Comment: 19 pages, 17 figure
Magnetic moment evolution and spin freezing in doped BaFe$_{2}$As$_{2}$

Fe-K$_{\beta}$ X-ray emission spectroscopy measurements reveal an asymmetric
doping dependence of the magnetic moments $\mu_\text{bare}$ in electron- and
hole-doped BaFe$_{2}$As$_{2}$. At low temperature, $\mu_\text{bare}$ is nearly
constant in hole-doped samples, whereas it decreases upon electron doping.
Increasing temperature substantially enhances $\mu_\text{bare}$ in the
hole-doped region, which is naturally explained by the theoretically predicted
crossover into a spin-frozen state. Our measurements demonstrate the importance
of Hund's coupling and electronic correlations, especially for hole-doped
BaFe$_{2}$As$_{2}$, and the inadequacy of a fully localized or fully itinerant
description of the 122 family of Fe pnictides
Artistic occupations are associated with a reduced risk of Parkinson's disease

Contains fulltext :
                  154567.pdf (publisher's version ) (Open Access)Parkinson's disease (PD) is preceded by a premotor phase of unknown duration. Dopaminergic degeneration during this phase may lead to subtle cognitive and behavioural changes, such as decreased novelty seeking. Consequently, premotor subjects might be most comfortable in jobs that do not require optimal dopamine levels, leading to an overrepresentation in structured and predictable occupations, or an underrepresentation in artistic occupations. In a case-control study, 750 men with PD (onset >/=40 years) and 1300 healthy men completed a validated questionnaire about their lifetime occupational status. Occupations were classified using the RIASEC model. Odds ratios (ORs) were calculated for the conventional and artistic categories, both for the most recent occupation before symptom onset, and for the very first occupation. Because farming has been associated with a PD risk, ORs were calculated separately for farming. A reduced risk of PD was found for men with an artistic occupation late in life (OR 0.14, 95 % CI 0.04-0.53), while an artistic first occupation did not prevent PD (OR 0.72, CI 0.32-1.59). Conventional occupations showed no increased risk (recent: OR 1.07, CI 0.70-1.64; first: OR 1.14, CI 0.77-1.71). In support of previous reports, farming was associated with an increased risk of PD (recent: OR 2.6, CI 1.4-4.6; first: OR 2.7, CI 1.6-4.5). PD patients were older than controls, but various statistical corrections for age all lead to similar results. Artistic occupations late in life are associated with a reduced risk of subsequent PD, perhaps because this reflects a better preserved dopaminergic state. No initial occupation predicted PD, suggesting that the premotor phase starts later in life
Charge Symmetry Breaking in Spin Dependent Parton Distributions and the
  Bjorken Sum Rule

We present the first determination of charge symmetry violation (CSV) in the
spin-dependent parton distribution functions of the nucleon. This is done by
determining the first two Mellin moments of the spin-dependent parton
distribution functions of the octet baryons from N_f = 2 + 1 lattice
simulations. The results are compared with predictions from quark models of
nucleon structure. We discuss the contribution of partonic spin CSV to the
Bjorken sum rule, which is important because the CSV contributions represent
the only partonic corrections to the Bjorken sum rule.Comment: 7 pages, 6 figures, 3 tables. arXiv admin note: text overlap with
  arXiv:1012.021
Role of GALNT2 in the modulation of ENPP1 expression, insulin signaling and action: GALNT2: A novel modulator of insulin signaling

Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin signaling and action. Understanding the mechanisms underlying ENPP1 expression may help unravel molecular mechanisms of insulin resistance. Recent data suggest a role of ENPP1-3'untraslated region (UTR), in controlling ENPP1 expression. We sought to identify trans-acting ENPP1-3'UTR binding proteins, and investigate their role on insulin signaling. By RNA pull-down, 49 proteins bound to ENPP1-3'UTR RNA were identified by mass spectrometry (MS). Among these, in silico analysis of genome wide association studies and expression profile datasets pointed to N-acetylgalactosaminyltransferase 2 gene (GALNT2) for subsequent investigations. Gene expression levels were evaluated by RT-PCR. Protein expression levels, IRS-1 and Akt phosphorylation were evaluated by Western blot. Insulin receptor (IR) autophosphorylation was evaluated by ELISA. GALNT2 down-regulation increased while GALNT2 over-expression reduced ENPP1 expression levels. In addition, GALNT2 down-regulation reduced insulin stimulation of IR, IRS-1 and Akt phosphorylation and insulin inhibition of phosphoenolpyruvate carboxykinase (PEPCK) expression, a key neoglucogenetic enzyme. Our data point to GALNT2 as a novel factor involved in the modulation of ENPP1 expression as well as insulin signaling and action in human liver HepG2 cell
Multi-wavelength observations of PKS 2155-304 with HESS.

The High Energy Stereoscopic System (HESS) has observed the high-frequency peaked BL Lac object PKS 2155- 304 in 2003 between October 19 and November 26 in Very High Energy (VHE) gamma-rays (E >= 160 GeV for these observations). Observations were carried out simultaneously with the Proportional Counter Array (PCA) on board the Rossi X-ray Timing Explorer satellite ( RXTE), the Robotic Optical Transient Search Experiment (ROTSE) and the Nancay decimetric radiotelescope (NRT). Intra-night variability is seen in the VHE band, the source being detected with a high significance on each night it was observed. Variability is also found in the X-ray and optical bands on kilosecond timescales, along with flux-dependent spectral changes in the X-rays. A transient X-ray event with a 1500 s timescale is detected, making this the fastest X-ray flare seen in this object. No correlation can be established between the X-ray and the gamma-ray fluxes, or any of the other wavebands, over the small range of observed variability. The average HESS spectrum shows a very soft power law shape with a photon index of 3.37 +/- 0.07(stat) +/- 0.10(sys). The energy outputs in the 2 - 10 keV and in the VHE gamma-ray range are found to be similar, with the X-rays and the optical fluxes at a level comparable to some of the lowest historical measurements, indicating that PKS 2155- 304 was in a low or quiescent state during the observations. Both a leptonic and a hadronic model are used to derive source parameters from these observations. These parameters are found to be sensitive to the model of Extragalactic Background Light (EBL) that attenuates the VHE signal at this source's redshift (z = 0.117). \u
Forward pi(+/-) production in p-O-2 and p-N-2 interactions at 12 GeV/c

Measurements of double-differential charged pion production cross-sections in interactions of 12 GeV/c protons on O-2 and N-2 thin targets are presented in the kinematic range 0.5 GeV/c <= p(pi) < 8 GeV/c and 50 mrad <= 0(pi) < 250 mrad (in the laboratory frame) and are compared with p-C results. For p-N-2 (p-O-2) interactions the analysis is performed using 38576 (7522) reconstructed secondary pions. The analysis uses the beam instrumentation and the forward spectrometer of the HARP experiment at CERN PS. The measured cross-sections have a direct impact on the precise calculation of atmospheric neutrino fluxes and on the improved reliability of extensive air shower simulations by reducing the uncertainties of hadronic interaction models in the low energy range. In particular, the present results allow the common hypothesis that p-C data can be used to predict the p-N-2 and p-O-2 pion production cross-sections to be tested
Spectral reflectance data of a high temperature stable solar selective coating based on MoSi2-Si3N4

Data of optical performance, thermal stability and ageing are given for solar selective coatings (SSC) based on a novel MoSi2-Si3N4 absorbing composite. SSC have been prepared as multilayer stacks formed by silver as metallic infrared reflector, a double layer composite and an antireflective layer (doi: 10.1016/j.solmat.2016.04.001 [1]). Spectroscopic reflectance data corresponding to the optical performance of samples after moderate vacuum annealing at temperatures up to 600 °C and after ageing test of more than 200 h with several heating-cooling cycles are shown hereThis work has been supported by European Commission under HITECO Collaborative project contract No. 256830 from the FP7-ENERGY program and by the CSIC PIE project E201460E108, by the Spanish MINECO through contract MAT2012-37276-C03-01 and by the Madrid Regional Government through contract P2013/MIT-2740. E.C. acknowledges MINECO for the “Formación Posdoctoral (JdC)” program (FPDI-2013
Search for a CP-odd Higgs boson decaying to Zh in pp collisions at root √s=8 TeV with the ATLAS detector

A search for a heavy, CP-odd Higgs boson, A, decaying into a Z boson and a 125 GeV Higgs boson,
 h, with the ATLAS detector at the LHC is presented. The search uses proton–proton collision data at
 a centre-of-mass energy of 8 TeV corresponding to an integrated luminosity of 20.3 fb−1. Decays of
 CP-even h bosons to ττ or bb pairs with the Z boson decaying to electron or muon pairs are considered,
 as well as h → bb decays with the Z boson decaying to neutrinos. No evidence for the production of
 an A boson in these channels is found and the 95% confidence level upper limits derived for σ(gg →
 A) × BR(A → Zh) × BR(h → f ¯
 f ) are 0.098–0.013 pb for f = τ and 0.57–0.014 pb for f = b in a range
 of mA = 220–1000 GeV. The results are combined and interpreted in the context of two-Higgs-doublet
 modelsWe acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Founda-tion, Germany; GSRT and NSRF, Greece; RGC, Hong Kong SAR, China; ISF, MINERVA, GIF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW and NCN, Poland; GRICES and FCT, Portugal; MNE/IFA, Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MIZŠ, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN and the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA) and in the Tier-2 facilities worldwid
Mesonephric adenocarcinoma of the cervix : case report and literature review

A mesonephric adenocarcinoma of the cervix is a very rare tumor deriving from remnants of the mesonephric duct. Differential diagnosis from other cervical carcinomas is difficult and little is known regarding its biological behavior, prognosis, and the optimal management strategy.We present a case of a mesonephric adenocarcinoma of the cervixwith a comprehensive reviewof the existing literature. In this case a 66-year-oldwoman presented with postmenopausal vaginal bleeding. Shewas diagnosedwith a FIGO stage IIB mesonephric adenocarcinoma of the cervix and treated with neoadjuvant chemoradiotherapy and aWertheim hysterectomy. The recovery from surgery was uneventful and the patient remains with no evidence of disease with 2 years of follow-up