pinecone/core-2020-05-10-deduplication huggingface dataset:
Immunohistochemical study of thyroid transcription factor-1 and surfactant-associated protein A for investigation of peripheral airway structure in perinatal fatality

We studied histopathological findings of the lungs in four cases where there was a suspicion of infanticide whereby an autopsy was performed. All four babies were born in full term delivery. It was difficult to discern whether the peripheral airways of the lungs were open or closed with conventional histological examination. Therefore immunohistochemistry with a combination of anti- thyroid
	transcription factor-1 (TTF-1) and anti- surfactant-associated protein A (PE-10) was used in order to elucidate the fundamental structures of the peripheral airways. TTF-1 highlighted nuclei of Clara cells
	and type II alveolar cells. The findings of immunohistochemistry with TTF-1 enabled us to more objectively recognize the peripheral airways: respiratory bronchioles and alveolar ducts, even in collapsed lungs. PE-10 was expressed in the cytoplasm of Clara cells, type II alveolar cells, and the
	substance of air space. Aspect for immunohistochemistry with PE-10 appeared to be granular in closed air space, whereas it appeared to be stretched membranously along the interalveolar septa in open air space. These findings suggest that application of immunohistochemistry with TTF-1 and
	PE-10 is a useful diagnostic tool in judging perinatal fatality
Beat-note interferometer for direct phase measurement of photonic information

[[abstract]]We describe a simple method of the beat-note interferometer that directly and dynamically measures the phase shift of light pulses induced by highly dispersive samples. Using the method, we show intuitively that the storage and retrieval of light pulses in a medium due to the effect of electromagnetically induced transparency is a coherent process and, quantitatively, that there is no observable phase shift caused by the process. This method is sensitive enough that it can be used to measure the phase of a light pulse with energy on the order of a dozen photons.[[fileno]]2010136010012[[department]]物理
Are there differences in responses to social identity questions in face-to-face versus telephone interviews? Results of an experiment on a longitudinal survey

This paper investigates the effect of interview mode (telephone vs. face-to-face) on responses to a 13-item module of identity questions covering distinct domains. With increasing moves towards mixed-mode implementation, especially in longitudinal surveys, establishing whether mode effects are likely to influence findings is of practical value. A growing number of studies explore mode effects; but the potential impact of mode on identity questions has not been investigated, even though such questions are increasingly being asked in multi-topic surveys. Adjusting for selection, we find little evidence for specific mode effects. The exception is responses on political identity: telephone responders are eight percentage points more likely to consider politics important to their identity. We do not find differences in data quality as measured by item non-response, straightlining, primacy and recency effects across modes. We conclude that mode effects are small for identity questions
Economic Implications of Water Efficiency Measures II: Cost Effectiveness of Composite Strategies

This is the final version of the article. Available from the publisher via the DOI in this record.This paper briefly describes the development and application of a tool for generating micro-components (e.g. baths, taps, showers, WCs, washing machines and dishwashers) based water efficient composite strategies and assesses their cost effectiveness using a number of economic assessment methods. A composite strategy is defined as a combination of micro-components that could deliver a given water efficiency level. The assessment results suggest that the economic performance of water efficient composite strategies varies considerably.
There is no linear relationship between water and energy consumption and the total cost associated with the strategies. Additionally, conventional cost assessment methods appear to be unsuitable for identifying the least cost options to consumers.The work was funded by the UK Engineering and Physical Sciences Research Council (EPSRC) and its support is thankfully acknowledged
Epithelial NAIPs protect against colonic tumorigenesis.

NLR family apoptosis inhibitory proteins (NAIPs) belong to both the Nod-like receptor (NLR) and the inhibitor of apoptosis (IAP) families. NAIPs are known to form an inflammasome with NLRC4, but other in vivo functions remain unexplored. Using mice deficient for all NAIP paralogs (Naip1-6(Δ/Δ)), we show that NAIPs are key regulators of colorectal tumorigenesis. Naip1-6(Δ/Δ) mice developed increased colorectal tumors, in an epithelial-intrinsic manner, in a model of colitis-associated cancer. Increased tumorigenesis, however, was not driven by an exacerbated inflammatory response. Instead, Naip1-6(Δ/Δ) mice were protected from severe colitis and displayed increased antiapoptotic and proliferation-related gene expression. Naip1-6(Δ/Δ) mice also displayed increased tumorigenesis in an inflammation-independent model of colorectal cancer. Moreover, Naip1-6(Δ/Δ) mice, but not Nlrc4-null mice, displayed hyper-activation of STAT3 and failed to activate p53 18 h after carcinogen exposure. This suggests that NAIPs protect against tumor initiation in the colon by promoting the removal of carcinogen-elicited epithelium, likely in a NLRC4 inflammasome-independent manner. Collectively, we demonstrate a novel epithelial-intrinsic function of NAIPs in protecting the colonic epithelium against tumorigenesis
Liquid water through density-functional molecular dynamics: plane-wave vs atomic-orbital basis sets

We determine and compare structural, dynamical, and electronic properties of liquid water at near ambient conditions through density-functional molecular dynamics simulations, when using either plane-wave or atomic-orbital basis sets. In both frameworks, the electronic structure and the atomic forces are self-consistently determined within the same theoretical scheme based on a nonlocal density functional accounting for van der Waals interactions. The overall properties of liquid water achieved within the two frameworks are in excellent agreement with each other. Thus, our study supports that implementations with plane-wave or atomic-orbital basis sets yield equivalent results and can be used indiscriminately in study of liquid water or aqueous solutions
Advances in the monitoring of geo-structure subjected to climate loading

The paper presents results achieved within the project MAGIC, a project funded by the European Commission under the Marie-Curie Industry Academia Partnerships and Pathways (IAPP) scheme. The project MAGIC aims to advance the state-of-the art in the monitoring of geo-structures subjected to climate loading by filling some of the gaps in current monitoring technologies. The project involves a partnership between academic and industrial partners to boost knowledge transfer and promote the development of 'industrial' instruments and services. The paper presents developments concerning the measurement of pore-water tension (suction in excess of 100 kPa) and the integration of geotechnical and geophysical monitoring
Trading-off accuracy vs energy in multicore processors via evolutionary algorithms combining loop perforation and static analysis-based scheduling

This work addresses the problem of energy efficient scheduling and allocation of tasks in multicore environments, where the tasks can permit certain loss in accuracy of either final or intermediate results, while still providing proper functionality. Loss in accuracy is usually obtained with techniques that decrease computational load, which can result in significant energy savings. To this end, in this work we use the loop perforation technique that transforms loops to execute a subset of their iterations, and integrate it in our existing optimisation tool for energy efficient scheduling in multicore environments based on evolutionary algorithms and static analysis for estimating energy consumption of different schedules. The approach is designed for multicore XMOS chips, but it can be adapted to any multicore environment with slight changes. The experiments conducted on a case study in different scenarios show that our new scheduler enhanced with loop perforation improves the previous one, achieving significant energy savings (31 % on average) for acceptable levels of accuracy loss
Development of taxane resistance in a panel of human lung cancer cell lines

Using a selection process designed to reflect clinically relevant conditions, a panel of taxane-selected variants were developed to study further the mechanisms of resistance in lung cancer. Unlike continuous or pulse exposure to high concentrations of chemotherapeutic drugs which yield high resistance and often cross resistance, most variants developed here displayed low level resistance to the selecting drug with slight cross-resistance. Pulsing with taxol resulted in more highly resistant clones (up to 51.4-fold). Analysis of taxol and taxotere in the four major lung cancer cell types showed the taxanes to be more effective against NSCLC (with the exception of SKMES-taxane selected variants) than against the SCLC. Comparison of taxol and taxotere shows that taxol induces higher levels of resistance than taxotere. Further, in taxotere-selected cell lines, the cells are more resistant to taxol than taxotere, suggesting that taxotere may be a superior taxane from a clinical view. Taxol treatment resulted in increased cross-resistance to 5-FU in all classes of lung cancer except DMS-53. The high levels of Pgp in the DMS-53 and selected variant suggests this mechanism is not related to Pgp expression. Analysis of the Pgp and MRP-1 status by combination inhibitory assays and Western blotting showed no consistent relationship between expression of the membrane pumps Pgp or MRP-1 and resistance. However, where high level resistance was seen, the parent cell line expressed Pgp or MRP-1 and was accompanied by increased levels in the variants. Overall we found that the clinically relevant models used here are useful for investigating mechanisms of taxane resistance
Novel synthesis and characterisation of 3,3-dimethyl-50-(2-benzothiazolyl)- spironaphth(indoline-2,30-[3H]naphth[2,1-b] [1,4]oxazine) derivatives

Novel modified spirooxazines (SOs) with additional chelating groups were synthesised and the crystal\ud
structure of one of these was determined. UV–vis spectroscopic characterization of the photoisomerization\ud
of the SO derivatives shows that the photochromic behaviour is altered with Zn2+ coordination. In\ud
particular, addition of a group as in carboxylic acid 5 to the indole section of the SO increases the lifetime\ud
of the merocyanine Zn 2+ complex by 20-fold compared to the methylated indole 6
Semi-automatic semantic enrichment of raw sensor data

One of the more recent sources of large volumes of generated data is sensor devices, where dedicated sensing equipment is used to monitor events and happenings in a wide range of domains, including monitoring human biometrics. In recent trials to examine the effects that key moments in movies have on the human body, we fitted fitted with a number of biometric sensor devices and monitored them as they watched a range of dierent movies in groups. The purpose of these experiments was to examine the correlation between humans' highlights in movies as observed from biometric sensors, and highlights in the same movies as identified by our automatic movie analysis techniques. However,the problem with this type of experiment is that both the analysis of the video stream and the sensor data readings are not directly usable\ud
in their raw form because of the sheer volume of low-level data values generated both from the sensors and from the movie analysis. This work describes the semi-automated enrichment of both video analysis and sensor data and the mechanism used to query the data in both centralised\ud
environments, and in a peer-to-peer architecture when the number of sensor devices grows to large numbers. We present and validate a scalable means of semi-automating the semantic enrichment of sensor data, thereby providing a means of large-scale sensor management
Network design: Taxi Planning

The effect of managing aircraft movements on the airport’s ground is an important tool that can alleviate the delays of flights, specially in peak hours or congested situations. Although some strategic design decisions regarding aeronautical and safety aspects have a main impact on the airport’s topology, there exists a number of other additional factors that must be evaluated according to the on ground operations, i.e. previous to the taking-off or after landing. Among these factors one can consider capacities at waiting points and directions of some corridors. These factors are related to the demand situation of a given period and influence the aircraft’s routing on the ground or short term Taxi Planning problem (or TP-S). While the TP-S problem studies the aircraft routing and scheduling on the airport’s ground under a dynamic point of view, this paper presents a Taxi Planning network design model (or TPND), attending to these additional factors of the airport’s topology and the conflicting movements of the aircraft on them with the same modelling approach used in the TP-S problem. The TPND model is formulated as a binary multicommodity network flow problem with additional side constraints under a multiobjective approach. The side constraints included are the classical limitations due to capacity and also as a distinctive approach, constraints that restrict the interference of aircraft in order to decrease the intervention of human controllers during the operations or increase their safety margins. The multiobjective approach adopted for the TPND model balances conflicting objectives: airport’s throughput, travel times, safety of operations and costs. In the paper computational results are included on two test airports solving the TPND model by “Branch and Bound” showing the effect of the conflicting objectives in the design decisions
A special perturbation method in orbital dynamics

The special perturbation method considered in this paper combines simplicity of computer implementation, speed and precision, and can propagate the orbit of any material particle. The paper describes the evolution of some orbital\ud
elements based in Euler parameters, which are constants in the unperturbed problem, but which evolve in the time scale imposed by the perturbation. The variation of parameters technique is used to develop expressions for the derivatives of seven elements for the general case, which includes any type of perturbation. These basic differential equations are slightly modified by introducing one additional equation for the time, reaching a total order of eight. The method was developed in the Grupo de Dinámica de Tethers (GDT) of the UPM, as a tool for dynamic simulations of tethers. However, it can be used in any other field and with any kind of orbit and perturbation. It is free of singularities related to small inclination and/or eccentricity. The use of Euler parameters makes it robust. The perturbation forces are handled in a very simple way: the method requires their components in the orbital frame or in an inertial frame. A comparison with other schemes is performed in the paper to show the good performance of the method
Electronic structure and optical properties in ZnO:M(Co, Cd). Effect of band-gap variation

ZnO doped with some transitions metals (ZnO:M) has several significant potential application. ZnO:Co is proposed to be used in advanced spintronic devices due to its high Curie temperature and large magnetic moments per transition metal. ZnO:Cd has potential applications in short-wavelength optoelectronic devices. This work focuses on an ab-initio study of the electronic and optical properties of ZnO:M doped with Co, and Cd. Theoretical calculations have been done with different computational codes, using the density functional theory (DFT) at the GGA and GGA+U level. The latter introduces a Hubbard term correction in the “d” levels of the Zn and Co. We used different supercells in order to have different realistic dilution levels which can be achieved in experiments. Doping effects on the features of the optical absorption are also studied and analysed in this work
Midday measurements of leaf water potential and stomatal conductance are highly correlated with daily water use of Thompson Seedless grapevines

A study was conducted to determine the relationship between midday measurements of vine water status and daily water use of grapevines measured with a weighing lysimeter. Water applications to the vines were terminated on August 24th for 9 days and again on September 14th for 22 days. Daily water use of the vines in the lysimeter (ETLYS) was approximately 40 L vine−1 (5.3 mm) prior to turning the pump off, and it decreased to 22.3 L vine−1 by September 2nd. Pre-dawn leaf water potential (ΨPD) and midday Ψl on August 24th were −0.075 and −0.76 MPa, respectively, with midday Ψl decreasing to −1.28 MPa on September 2nd. Leaf g s decreased from ~500 to ~200 mmol m−2 s−1 during the two dry-down periods. Midday measurements of g s and Ψl were significantly correlated with one another (r = 0.96) and both with ETLYS/ETo (r = ~0.9). The decreases in Ψl, g s, and ETLYS/ETo in this study were also a linear function of the decrease in volumetric soil water content. The results indicate that even modest water stress can greatly reduce grapevine water use and that short-term measures of vine water status taken at midday are a reflection of daily grapevine water us
Geometric tools in Juan de Álava's stonecutting workshop

Stonemasonry of the Gothic vault in its\ud
totality is based upon geometry of the line,\ud
whereas classic stereotomy relies on the\ud
comprehensive knowledge of the surface and the\ud
highly sophisticated sides of the voussoirs\ud
necessary for its vaults. It is obvious that this leap\ud
in the art of construction was paralleled and\ud
accompanied by an extension of the horizons of\ud
geometry. In Spain, it was made possible thanks\ud
to the centuries-old tradition of stone building\ud
begun in the most remote medieval times and to\ud
the presence of outstanding architects or\ud
stonemasons such as Juan de Álava, whose\ud
professional work surpassed the established limits\ud
and provided the art of building with new\ud
instruments
Capital Income and Income Inequality: Evidence from Urban China

Using urban household survey data collected by National Bureau of Statistics of China from 1988-2009, this study examines the distribution, composition, and changes of capital income and its contribution to income inequality. The data shows that capital income has increased considerably in past 20 years in urban China. Although the average value of capital income is still relatively low, the dispersion of capital income is significant, and for high-income earners capital income is substantial. Compared to other forms of income, capital income is distributed the most unequally, and its contribution to total income inequality has been growing. This study also examines capital income in China’s western, central, and eastern regions separately, and finds that capital income is highest and contributes the most to income inequality in the eastern region.
Solving the linear interval tolerance problem for weight\ud
initialization of neural networks

Determining good initial conditions for an algorithm used to train a neural network is considered a parameter estimation problem dealing with uncertainty about the initial weights. Interval Analysis approaches model uncertainty in parameter estimation problems using intervals and formulating tolerance problems. Solving a tolerance problem is defining lower and upper bounds of the intervals so that the system functionality is guaranteed within predefined limits. The aim of this paper is to show how the problem of determining the initial weight intervals of a neural network can be defined in terms of solving a linear interval tolerance problem. The proposed Linear Interval Tolerance Approach copes with uncertainty about the initial weights without any previous knowledge or specific assumptions on the input data as required by approaches such as fuzzy sets or rough sets. The proposed method is tested on a number of well known benchmarks for neural networks trained with the back-propagation family of algorithms. Its efficiency is evaluated with regards to standard performance measures and the results obtained are compared against results of a number of well known and established initialization\ud
methods. These results provide credible evidence that the proposed method outperforms classical weight initialization methods
Experimental characterization and thermoviscoelastic modeling of strain and stress recoveries of an amorphous polymer network

An acrylate polymer network was submitted to thermomechanical shape memory cycles. The set of experiments characterized the material stress-free strain recovery and the strain-constrained stress recovery in uniaxial tension. Experimental parameters like temperature of strain fixation, amount of strain and heating rate, were varied in order to provide a relatively complete set of experimental data. A model combining the amorphous polymer viscoelasticity and its time–temperature superposition property was used to predict the shape memory behavior of the acrylate polymer network. All the model parameters were characterized using classical tests for mechanical characterization of polymers, which do not include shape memory tests. Model predictions obtained by finite element simulations compared very well to the experimental data and therefore the model relevance for computer assisted application design was assessed.AN
Design of a spatial database to analyze the forms and responsiveness of an urban environment using an ontological approach

This paper introduces a spatial database and ontology-enabled framework that models and operationalizes the relation between urban forms and their responsiveness to the needs of its user. The objective is to offer a framework that provides a practical implementation of the concept of responsive environment introduced by Bentley, Alcock, Murrain, McGlynn and Smith (1985) in order to provide enough reusability and flexibility to reflect different urban modeling viewpoints and conceptualizations. The developed system is organized in three modules: the first and second modules model the ontology of a responsive environment and the layout of an urban environment while the third module is a spatial database that supports further computational analysis of urban forms. We applied several spatial data metrics that analyze the structural properties of urban forms and the emerging opportunities as identified by the notion of responsive environments. The framework is experimented and applied to the district 12, region 4 of the city of Tehran in Iran. The modeling abstractions lead to the generation of several semantic bridge rules and map layers that reflect different levels of urban responsiveness. The emerging patterns are qualitatively evaluated and found to be correlated with inhabitants' own perception of an urban environment. The results show that the suggested framework can be applied to the analysis of the responsive environments of urban forms