pinecone/core-2020-05-10-deduplication huggingface dataset:
Pharmacological stimulation of edar signaling in the adult enhances sebaceous gland size and function.

Impaired ectodysplasin A (EDA) receptor (EDAR) signaling affects ectodermally derived structures including teeth, hair follicles, and cutaneous glands. The X-linked hypohidrotic ectodermal dysplasia (XLHED), resulting from EDA deficiency, can be rescued with lifelong benefits in animal models by stimulation of ectodermal appendage development with EDAR agonists. Treatments initiated later in the developmental period restore progressively fewer of the affected structures. It is unknown whether EDAR stimulation in adults with XLHED might have beneficial effects. In adult Eda mutant mice treated for several weeks with agonist anti-EDAR antibodies, we find that sebaceous gland size and function can be restored to wild-type levels. This effect is maintained upon chronic treatment but reverses slowly upon cessation of treatment. Sebaceous glands in all skin regions respond to treatment, although to varying degrees, and this is accompanied in both Eda mutant and wild-type mice by sebum secretion to levels higher than those observed in untreated controls. Edar is expressed at the periphery of the glands, suggesting a direct homeostatic effect of Edar stimulation on the sebaceous gland. Sebaceous gland size and sebum production may serve as biomarkers for EDAR stimulation, and EDAR agonists may improve skin dryness and eczema frequently observed in XLHED
Effect of gestational age at birth on neonatal outcomes in gastroschisis.

Induced birth of fetuses with gastroschisis from 34weeks gestational age (GA) has been proposed to reduce bowel damage. We aimed to determine the effect of birth timing on time to full enteral feeds (ENT), length of hospital stay (LOS), and sepsis.
A retrospective analysis (2000-2014) of gastroschisis born at ≥34weeks GA was performed. Associations between birth timing and outcomes were analyzed by Mann-Whitney test, Cox regression, and Fisher's exact test.
217 patients were analyzed. Although there was no difference in ENT between those born at 34-36+6weeks GA (median 28 range [6-639] days) compared with ≥37weeks GA (27 [8-349] days) when analyzed by Mann-Whitney test (p=0.5), Cox regression analysis revealed that lower birth GA significantly prolonged ENT (p=0.001). LOS was significantly longer in those born at 34-36+6weeks GA (42 [8-346] days) compared with ≥37weeks GA 34 [11-349] days by both Mann-Whitney (p=0.02) and Cox regression analysis (p&lt;0.0005). Incidence of sepsis was higher in infants born at 34-36+6weeks (32%) vs. infants born at ≥37weeks (17%; p=0.02).
Early birth of fetuses with gastroschisis was associated with delay in reaching full enteral feeds, prolonged hospitalization, and a higher incidence of sepsis
Search for WZ resonances in the fully leptonic channel using pp collisions at √s = 8 TeV with the ATLAS detector

A search for resonant WZ production in the ℓνℓ[superscript ′]ℓ[superscript ′] (ℓ,ℓ[superscript ′] =e,μ) decay channel using 20.3 fb[superscript −1] of √s = 8 TeV collision data collected by the ATLAS experiment at LHC is presented. No significant deviation from the Standard Model prediction is observed and upper limits on the production cross sections of WZ   resonances from an extended gauge model W[superscript ′] and from a simplified model of heavy vector triplets are derived. A corresponding observed (expected) lower mass limit of 1.52 (1.49) TeV is derived for the W[superscript ′] at the 95% confidence level.United States. Dept. of EnergyNational Science Foundation (U.S.)Brookhaven National Laborator
Measurement of the inelastic cross section in proton–lead collisions at $\sqrt{^{s}NN}$ = 5.02 TeV

The inelastic hadronic cross section in proton–lead collisions at a centre-of-mass energy per nucleon pair of 5.02 TeV is measured with the CMS detector at the LHC. The data sample, corresponding to an integrated luminosity of L=12.6±0.4 nb$^{−1}$ , has been collected with an unbiased trigger for inclusive particle production. The cross section is obtained from the measured number of proton–lead collisions with hadronic activity produced in the pseudorapidity ranges 3<η<5 and/or −5<η<−3 , corrected for photon-induced contributions, experimental acceptance, and other instrumental effects. The inelastic cross section is measured to be $σ_{inel}(pPb)$=2061±3(stat)±34(syst)±72(lumi) mb . Various Monte Carlo generators, commonly used in heavy ion and cosmic ray physics, are found to reproduce the data within uncertainties. The value of $σ_{inel}(pPb)$ is compatible with that expected from the proton–proton cross section at 5.02 TeV scaled up within a simple Glauber approach to account for multiple scatterings in the lead nucleus, indicating that further net nuclear corrections are small
Dust properties in H II regions in M 33

Context. The infrared emission (IR) of the interstellar dust has been claimed to be a tracer of the star formation rate. However, the conversion of the IR emission into star formation rate can be strongly dependent on the physical properties of the dust, which are a ected by the environmental conditions where the dust is embedded. Aims. We study here the dust properties of a set of Hii regions in the Local Group galaxy M33 presenting different spatial configurations between the stars, gas, and dust to understand the dust evolution indierent environments. Methods. We modelled the spectral energy distribution (SED) of each region using the DustEM tool and obtained the mass relative to hydrogen for very small grains (VSG, YVSG), polycyclic aromatic hydrocarbons (YPAH), and big grains (BG, YBG). We furthermore performed a pixel-by-pixel SED modelling and derived maps of the relative mass of each grain type for the whole surface of the two most luminous Hii regions in M33, NGC 604 and NGC 595. Results. The relative mass of the VSGs (YVSG/YTOTAL) changes with the morphology of the region: YVSG/YTOTAL is a factor of ∼1.7 higher for Hii regions classified as filled and mixed than for regions presenting a shell structure. The enhancement in VSGs within NGC 604 and NGC 595 is correlated to expansive gas structures with velocities ≥50 km s. The gas-to-dust ratio derived for the Hii regions in our sample exhibits two regimes related to the Hi.H2 transition of the interstellar medium (ISM). Regions corresponding to the Hi diffuse regime present a gas-to-dust ratio compatible with the expected value if we assume that the gas-to-dust ratio scales linearly with metallicity, while regions corresponding to a H2 molecular phase present a flatter dust-gas surface density distribution. Conclusions. The fraction of VSGs can be affected by the conditions of the interstellar environment: strong shocks of ∼5090km s existing in the interior of the most luminous Hii regions can lead to fragmentation of BGs into smaller ones, while the more evolved shell and clear shell objects provide a more quiescent environment where reformation of dust BGs might occur. The gas-to-dust variations found in this analysis might imply that grain coagulation and/or gas-phase metal incorporation into the dust mass is occurring in the interior of the Hii regions in M33. © 2016 ESO.Part of this research has been supported by the PERG08-GA-2010-276813 from the EC. This work was partially supported by the Junta de Andalucia Grant FQM108 and Spanish MEC Grants, AYA-2011-24728 and AYA-2014-53506-P. EPM thanks Spanish MINECO grant AYA-2013-47742-C4-1-P of the Spanish Plan for Astronomy and Astrophysics. This work was in part supported through NSF ATI grant 1106284.Peer Reviewe
Direct photon production in Pb–Pb collisions at sNN=2.76 TeV

AbstractDirect photon production at mid-rapidity in Pb–Pb collisions at sNN=2.76 TeV was studied in the transverse momentum range 0.9<pT<14 GeV/c. Photons were detected with the highly segmented electromagnetic calorimeter PHOS and via conversions in the ALICE detector material with the e+e− pair reconstructed in the central tracking system. The results of the two methods were combined and direct photon spectra were measured for the 0–20%, 20–40%, and 40–80% centrality classes. For all three classes, agreement was found with perturbative QCD calculations for pT≳5 GeV/c. Direct photon spectra down to pT≈1 GeV/c could be extracted for the 20–40% and 0–20% centrality classes. The significance of the direct photon signal for 0.9<pT<2.1 GeV/c is 2.6σ for the 0–20% class. The spectrum in this pT range and centrality class can be described by an exponential with an inverse slope parameter of (297±12stat±41syst) MeV. State-of-the-art models for photon production in heavy-ion collisions agree with the data within uncertainties
Pair and single neutron transfer with Borromean 8He

AbstractDirect observation of the survival of 199Au residues after 2n transfer in the He8+Au197 system and the absence of the corresponding 67Cu in the He8+Cu65 system at various energies are reported. The measurements of the surprisingly large cross sections for 199Au, coupled with the integral cross sections for the various Au residues, is used to obtain the first model-independent lower limits on the ratio of 2n to 1n transfer cross sections from 8He to a heavy target. A comparison of the transfer cross sections for 6,8He on these targets highlights the differences in the interactions of these Borromean nuclei. These measurements for the most neutron-rich nuclei on different targets highlight the need to probe the reaction mechanism with various targets and represent an experimental advance towards understanding specific features of pairing in the dynamics of dilute nuclear systems
Evolutionary Genomics and Conservation of the Endangered Przewalski’s Horse

SummaryPrzewalski’s horses (PHs, Equus ferus ssp. przewalskii) were discovered in the Asian steppes in the 1870s and represent the last remaining true wild horses. PHs became extinct in the wild in the 1960s but survived in captivity, thanks to major conservation efforts. The current population is still endangered, with just 2,109 individuals, one-quarter of which are in Chinese and Mongolian reintroduction reserves [1]. These horses descend from a founding population of 12 wild-caught PHs and possibly up to four domesticated individuals [2–4]. With a stocky build, an erect mane, and stripped and short legs, they are phenotypically and behaviorally distinct from domesticated horses (DHs, Equus caballus). Here, we sequenced the complete genomes of 11 PHs, representing all founding lineages, and five historical specimens dated to 1878–1929 CE, including the Holotype. These were compared to the hitherto-most-extensive genome dataset characterized for horses, comprising 21 new genomes. We found that loci showing the most genetic differentiation with DHs were enriched in genes involved in metabolism, cardiac disorders, muscle contraction, reproduction, behavior, and signaling pathways. We also show that DH and PH populations split ∼45,000 years ago and have remained connected by gene-flow thereafter. Finally, we monitor the genomic impact of ∼110 years of captivity, revealing reduced heterozygosity, increased inbreeding, and variable introgression of domestic alleles, ranging from non-detectable to as much as 31.1%. This, together with the identification of ancestry informative markers and corrections to the International Studbook, establishes a framework for evaluating the persistence of genetic variation in future reintroduced populations
Noncritical M-theory and the Gross–Neveu model in 2+1 dimensions

AbstractWe point out a nontrivial connection between the model proposed by Hořava and Keeler as a candidate for noncritical M-theory and the Gross–Neveu model with fermionic fields obeying periodic boundary conditions in 2+1 dimensions. Specifically, the vacuum energy of the former is identified with the large-N free-energy of the latter up to an overall constant. This identification involves an appropriate analytic continuation of the subtraction point in noncritical M-theory, which is related to the volume of the Liouville dimension. We show how the world-sheet cosmological constant may be obtained from the Gross–Neveu model. At its critical point, which is given in terms of the golden mean, the values of the vacuum energy and of the cosmological constant are 4/5 and 2/5 of the corresponding values at infinite string coupling constant
Slow wave sleep and accelerated forgetting

AbstractWe investigated whether the benefit of slow wave sleep (SWS) for memory consolidation typically observed in healthy individuals is disrupted in people with accelerated long-term forgetting (ALF) due to epilepsy. SWS is thought to play an active role in declarative memory in healthy individuals and, furthermore, electrographic epileptiform activity is often more prevalent during SWS than during wakefulness or other sleep stages. We studied the relationship between SWS and the benefit of sleep for memory retention using a word-pair associates task. In both the ALF and the healthy control groups, sleep conferred a memory benefit. However, the relationship between the amount of SWS and sleep-related memory benefits differed significantly between the groups. In healthy participants, the amount of SWS correlated positively with sleep-related memory benefits. In stark contrast, the more SWS, the smaller the sleep-related memory benefit in the ALF group. Therefore, contrary to its role in healthy people, SWS-associated brain activity appears to be deleterious for memory in patients with ALF
Structure, mechanism and cooperation of bacterial multidrug transporters

Cells from all domains of life encode energy-dependent trans-membrane transporters that can expel harmful substances including clinically applied therapeutic agents. As a collective body, these transporters perform as a super-system that confers tolerance to an enormous range of harmful compounds and consequently aid survival in hazardous environments. In the Gram-negative bacteria, some of these transporters serve as energy-transducing components of tripartite assemblies that actively efflux drugs and other harmful compounds, as well as deliver virulence agents across the entire cell envelope. We draw together recent structural and functional data to present the current models for the transport mechanisms for the main classes of multi-drug transporters and their higher-order assemblies
Flavor SU(3) properties of beauty tetraquark states with three different light quarks

AbstractBeauty tetraquark states X(b¯q′q″q¯) composed of b¯sud¯, b¯dsu¯, and b¯uds¯, are unique that all the four valence quarks are different. Although the claim of existence of the first two states by D0 was not confirmed by data from LHCb, the possibility of such states still generated a lot of interests and should be pursued further. Non-observation of X(b¯q′q″q¯) states by LHCb may be just due to a still lower production rate than the limit of LHCb or at some different mass ranges. In this work we use light quark SU(3) flavor symmetry as guideline to classify symmetry properties of beauty tetraquark states. The multiplets which contain states with three different light quarks must be one of 6¯ or 15 of SU(3) representations. We study possible decays of such a tetraquark state into a B meson and a light pseudoscalar octet meson by constructing a leading order chiral Lagrangian, and also provide search strategies to determine whether a given tetraquark state of this type belongs to 6¯ or 15. If X(b¯q′q″q¯) belongs to 15, there are new doubly charged tetraquark states b¯uud¯ and b¯uus¯
Marine and terrestrial environmental changes in NW Europe preceding carbon release at the Paleocene–Eocene transition

AbstractEnvironmental changes associated with the Paleocene–Eocene thermal maximum (PETM, ∼56Ma) have not yet been documented in detail from the North Sea Basin. Located within proximity to the North Atlantic igneous province (NAIP), the Kilda Basin, and the northern rain belt (paleolatitude 54°N) during the PETM, this is a critical region for testing proposed triggers of atmospheric carbon release that may have caused the global negative carbon isotope excursion (CIE) in marine and terrestrial environments. The CIE onset is identified from organic matter δ13C in exceptional detail within a highly expanded sedimentary sequence. Pollen and spore assemblages analysed in the same samples for the first time allow a reconstruction of possible changes to vegetation on the surrounding landmass. Multiproxy palynological, geochemical, and sedimentologic records demonstrate enhanced halocline stratification and terrigenous deposition well before (103yrs) the CIE, interpreted as due to either tectonic uplift possibly from a nearby magmatic intrusion, or increased precipitation and fluvial runoff possibly from an enhanced hydrologic cycle. Stratification and terrigenous deposition increased further at the onset and within the earliest CIE which, coupled with evidence for sea level rise, may be interpreted as resulting from an increase in precipitation over NW Europe consistent with an enhanced hydrologic cycle in response to global warming during the PETM. Palynological evidence indicates a flora dominated by pollen from coastal swamp conifers before the CIE was abruptly replaced with a more diverse assemblage of generalist species including pollen similar to modern alder, fern, and fungal spores. This may have resulted from flooding of coastal areas due to relative sea level rise, and/or ecologic changes forced by climate. A shift towards more diverse angiosperm and pteridophyte vegetation within the early CIE, including pollen similar to modern hickory, documents a long term change to regional vegetation
Exact sign structure of the t–J chain and the single hole ground state

AbstractInjecting a single hole into a one-dimensional Heisenberg spin chain is probably the simplest case of doping a Mott insulator. The motion of such a single hole will generally induce a many-body phase shift, which can be identified by an exact sign structure of the model known as the phase string. We show that the sign structure is nontrivial even in this simplest problem, which is responsible for the essential properties of Mott physics. We find that the characteristic momentum structure, the Luttinger liquid behavior, and the quantum phase interference of the hole under a periodic boundary condition can all be attributed to it. We use the density matrix renormalization group (DMRG) numerical simulation to make a comparative study of the t–J chain and a model in which the sign structure is switched off. We further show that the key DMRG results can be reproduced by a variational wave function with incorporating the correct sign structure. Physical implications of the sign structure for doped Mott insulators in general are also discussed
Comparing the Folding and Misfolding Energy Landscapes of Phosphoglycerate Kinase

AbstractPartitioning of polypeptides between protein folding and amyloid formation is of outstanding pathophysiological importance. Using yeast phosphoglycerate kinase as model, here we identify the features of the energy landscape that decide the fate of the protein: folding or amyloidogenesis. Structure formation was initiated from the acid-unfolded state, and monitored by fluorescence from 10 ms to 20 days. Solvent conditions were gradually shifted between folding and amyloidogenesis, and the properties of the energy landscape governing structure formation were reconstructed. A gradual transition of the energy landscape between folding and amyloid formation was observed. In the early steps of both folding and misfolding, the protein searches through a hierarchically structured energy landscape to form a molten globule in a few seconds. Depending on the conditions, this intermediate either folds to the native state in a few minutes, or forms amyloid fibers in several days. As conditions are changed from folding to misfolding, the barrier separating the molten globule and native states increases, although the barrier to the amyloid does not change. In the meantime, the native state also becomes more unstable and the amyloid more stable. We conclude that the lower region of the energy landscape determines the final protein structure
Correlating Charge Movements with Local Conformational Changes of a Na+-Coupled Cotransporter

AbstractTo gain insight into the steady-state and dynamic characteristics of structural rearrangements of an electrogenic secondary-active cotransporter during its transport cycle, two measures of conformational change (pre-steady-state current relaxations and intensity of fluorescence emitted from reporter fluorophores) were investigated as a function of membrane potential and external substrate. Cysteines were substituted at three believed-new sites in the type IIb Na+-coupled inorganic phosphate cotransporter (SLC34A2 flounder isoform) that were predicted to be involved in conformational changes. Labeling at one site resulted in substantial suppression of transport activity, whereas for the other sites, function remained comparable to the wild-type. For these mutants, the properties of the pre-steady-state charge relaxations were similar for each, whereas fluorescence intensity changes differed significantly. Fluorescence changes could be accounted for by simulations using a five-state model with a unique set of apparent fluorescence intensities assigned to each state according to the site of labeling. Fluorescence reported from one site was associated with inward and outward conformations, whereas for the other sites, including four previously indentified sites, emissions were associated principally with one or the other orientation of the transporter. The same membrane potential change induced complementary changes in fluorescence at some sites, which suggested that the microenvironments of the respective fluorophores experience concomitant changes in polarity. In response to step changes in voltage, the pre-steady-state current relaxation and the time course of change in fluorescence intensity were described by single exponentials. For one mutant the time constants matched well with and without external Na+, providing direct evidence that this label reports conformational changes accompanying intrinsic charge movement and cation interactions
Probing the mechanism of EWSB with a rho-parameter defined in terms of Higgs couplings

AbstractA definition of the rho-parameter based on the Higgs couplings with the gauge bosons, ρHi≡gHiWW/(gHiZZc2W), is proposed as a new probe into the origin of the mechanism of electroweak symmetry breaking. While ρhSM=1 holds in the standard model, deviations from one for ρHi are predicted in models with extended Higgs sector. We derive a general expression of ρHi for a model with arbitrary Higgs multiplets, and discuss its size within the context of specific models with Higgs triplets, including the “Little Higgs” models recently proposed. We find the even for Higgs sectors that incorporate the custodial symmetry to make ρ=1, one could have ρHi≠1, which could be tested at the level of a few percent, with the precision Higgs measurements expected at the next linear collider (NLC)
The soft supersymmetry breaking in D=5 supergravity compactified on S1/Z2 orbifolds

AbstractWe study the origin of the supersymmetry breaking induced by the mediation of gravity and the radion multiplet from the hidden to the visible brane in the context of the N=2, D=5 supergravity compactified on S1/Z2 orbifolds. The soft supersymmetry breaking terms for scalar masses, trilinear scalar couplings and gaugino masses are calculated to leading order in the five-dimensional Newton's constant k52 and the gravitino mass m3/2. These are finite and non-vanishing, with the scalar soft masses being non-tachyonic, and are all expressed in terms of the gravitino mass and the length scale R of the fifth dimension. The soft supersymmetry breaking parameters are thus correlated and the phenomenological implications are discussed