pinecone/core-2020-05-10-deduplication huggingface dataset:
Characteristics of patients with haematological and breast cancer (1996–2009) who died of heart failure-related causes after cancer therapy

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Aims To describe the characteristics and time to death of patients with breast or haematological cancer who died of heart failure (HF) after cancer therapy. Patients with an index admission for HF who died of HF-related causes (IAHF) and those with no index admission for HF who died of HF-related causes (NIAHF) were compared. \ud
Methods and results We performed a linked data analysis of cancer registry, death registry, and hospital administration records (n = 15 987). Index HF admission must have occurred after cancer diagnosis. Of the 4894 patients who were deceased (30.6% of cohort), 734 died of HF-related causes (50.1% female) of which 279 (38.0%) had at least one IAHF (41.9% female) post-cancer diagnosis. Median age was 71 years [interquartile range (IQR) 62–78] for IAHF and 66 years (IQR 56–74) for NIAHF. There were fewer chemotherapy separations for IAHF patients (median = 4, IQR 2–9) compared with NIAHF patients (median = 6, IQR 2–12). Of the IAHF patients, 71% had died within 1 year of the index HF admission. There was no significant difference in HF-related mortality in IAHF patients compared with NIAHF (HR, 1.10, 95% CI, 0.94–\ud
1.29, P= 0.225). \ud
Conclusions The profile of IAHF patients who died of HF-related causes after cancer treatment matched the current profile of HF in the general population (over half were aged ≥70 years). However, NIAHF were younger (62% were aged ≤69 years), female patients with breast cancer that died of HF-related causes before hospital admission for HF-related causes—a group that may have been undiagnosed or undertreated until death
X(1576) as diquark–antidiquark bound state

AbstractWe propose that the broad 1−− resonance structure recently discovered by BES in J/ψ→K+K−π0 is the P-wave excitation of a diquark–antidiquark bound state. This interpretation implies that there exists a negative parity, vector nonet. A rough estimate of the mass spectrum of the nonet is presented, and the prediction for the mass of X(1576) is consistent with the experimental data. The OZI allowed strong decays are studied, it can decay into two pseudoscalars or one pseudoscalar plus one vector meson. A crucial prediction is that X(1576) should dominantly decay into K+K−, KLKS, ϕπ0. The observation of I3=1 or I3=−1 states which predominantly decays into strange mesons could provide another important test to our proposal. To search the charged I3=1 isospin partner of X(1576), careful search in J/ψ→K+KLπ−, J/ψ→K+KSπ− and J/ψ→ϕπ+π− is suggested
Charm meson production from meson–nucleon scattering

AbstractUsing an effective hadronic Lagrangian with physical hadron masses and coupling constants determined either empirically or from SU(4) flavor symmetry, we study the production cross sections of charm mesons from pion and rho meson interactions with nucleons. With a cutoff parameter of 1 GeV at interaction vertices as usually used in studying the cross sections for J/ψ absorption and charm meson scattering by hadrons, we find that the cross sections for charm meson production have values of a few tenth of mb and are dominated by the s channel nucleon pole diagram. Relevance of these reactions to charm meson production in relativistic heavy ion collisions is discussed
The first attempt to create a national strategy for reducing waiting times in Poland: Will it succeed?

AbstractThe waiting lists package, proposed in March 2014, is the first attempt to create a national strategy to reduce waiting times for specialist care in Poland. The policy proposes a number of measures directed at primary, specialist ambulatory and hospital care with the goal of shifting patients to the lowest possible level of care. Initially, it has been welcomed by the patients and there has been, so far, no strong opposition against the reform from other stakeholders. However, this may be because there is some disbelief that the policy would actually be implemented (due to limited funding available for its implementation) and because some of the proposed changes are vague and have yet to be clarified. One stakeholder group that may obstruct the implementation of the reform, if they are not satisfied with the final shape of the proposed measures, is the primary care doctors. They are directly affected by the reform and enjoy a relatively strong bargaining position compared to other groups of medical professionals. Thus, the future of the reform remains uncertain
Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)

Protein-energy wasting (PEW), a term proposed by the International Society of Renal Nutrition and Metabolism (ISRNM), refers to the multiple nutritional and catabolic alterations that occur in chronic kidney disease (CKD) and associate with morbidity and mortality. To increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of PEW, ISRNM provides this consensus statement of current knowledge on the etiology of PEW syndrome in CKD. Although insufficient food intake (true undernutrition) due to poor appetite and dietary restrictions contribute, other highly prevalent factors are required for the full syndrome to develop. These include uremia-induced alterations such as increased energy expenditure, persistent inflammation, acidosis, and multiple endocrine disorders that render a state of hypermetabolism leading to excess catabolism of muscle and fat. In addition, comorbid conditions associated with CKD, poor physical activity, frailty, and the dialysis procedure per se further contribute to PEW
A gauge-independent mechanism for confinement and mass gap: Part 2. G=SU(2) and D=3

AbstractWe apply to the case of gauge group G=SU(2) in three dimensions a recently proposed gauge-independent mechanism for confinement that is based on a particular form of the dual spin foam framework for lattice gauge theory. Explicit formulae for interaction factors and their asymptotics are introduced and their behavior in different sectors of the theory are identified and analyzed. We arrive at several elementary properties of the dual theory that represent one scenario by which confinement may be realized at weak coupling. We conclude with an outlook for further development of this approach
Non-uniform painless decompositions for anisotropic Besov and Triebel–Lizorkin spaces

AbstractIn this article we construct affine systems that provide a simultaneous atomic decomposition for a wide class of functional spaces including the Lebesgue spaces Lp(Rd), 1<p<+∞. The novelty and difficulty of this construction is that we allow for non-lattice translations.We prove that for an arbitrary expansive matrix A and any set Λ—satisfying a certain spreadness condition but otherwise irregular—there exists a smooth window whose translations along the elements of Λ and dilations by powers of A provide an atomic decomposition for the whole range of the anisotropic Triebel–Lizorkin spaces. The generating window can be either chosen to be bandlimited or to have compact support.To derive these results we start with a known general “painless” construction that has recently appeared in the literature. We show that this construction extends to Besov and Triebel–Lizorkin spaces by providing adequate dual systems
Stability of the graviton Bose–Einstein condensate in the brane-world

AbstractWe consider a solution of the effective four-dimensional Einstein equations, obtained from the general relativistic Schwarzschild metric through the principle of Minimal Geometric Deformation (MGD). Since the brane tension can, in general, introduce new singularities on a relativistic Eötvös brane model in the MGD framework, we require the absence of observed singularities, in order to constrain the brane tension. We then study the corresponding Bose–Einstein condensate (BEC) gravitational system and determine the critical stability region of BEC MGD stellar configurations. Finally, the critical stellar densities are shown to be related with critical points of the information entropy
Dispelling the N3 myth for the kt jet-finder

AbstractAt high-energy colliders, jets of hadrons are the observable counterparts of the perturbative concepts of quarks and gluons. Good procedures for identifying jets are central to experimental analyses and comparisons with theory. The kt family of successive recombination jet finders has been widely advocated because of its conceptual simplicity and flexibility and its unique ability to approximately reconstruct the partonic branching sequence in an event. Until now however, it had been believed that for an ensemble of N particles the algorithmic complexity of the kt jet finder scaled as N3, a severe issue in the high multiplicity environments of LHC and heavy-ion colliders. We here show that the computationally complex part of kt jet-clustering can be reduced to two-dimensional nearest neighbour location for a dynamic set of points. Borrowing techniques developed for this extensively studied problem in computational geometry, kt jet-finding can then be performed in NlnN time. Code based on these ideas is found to run faster than all other jet finders in current use
Follow-up of obstructive sleep apnea in children

AbstractIntroductionthe evolution of snoring and OSAS in children is not well established since few studies of patients without surgical treatment have been published.Objectiveto evaluate the evolution of sleep disordered breathing in children who had not been submitted to upper airway surgery.Methodtwenty-six children with snoring who had not undergone upper airway surgery were evaluated prospectively. Patients were evaluated by full physical examination and nocturnal polysomnography, after which they were divided into 2 groups: apnea (16 children) and snoring (10 children). After 6 months following the initial evaluation, patients were submitted to a new nocturnal polysomnography, and all data were compared to those of the first examination.Resultsthe groups did not show any differences regarding age, weight, height and airway physical examination. After 6 months of follow-up, the apnea index did not change, but the respiratory disturbance index increased in the snoring group and the number of hypopneas decreased in the group apnea.Conclusionthere was an increase in the percentage of N1 sleep stage and the respiratory disturbance index in the patients with primary snore. The AHI did not show significant alteration in both groups, but the number of hypopneas decreased in patients with SAOS
A bulk effect to SUSY effective potential in a 5D super-Yang–Mills model

AbstractSupersymmetric effective potential of a 5D super-Yang–Mills model compactified on S1/Z2, i.e., on an interval l of extra dimension, is estimated at the 1-loop level by the auxiliary field tadpole method. For the sake of infinite towers of Kaluza–Klein excitation modes of bulk fields involved in the tadpoles, there arises a definite bulk effect of linear growth of the effective potential along with the cutoff Λ which is greatly suppressed by l to produce a finite contribution. Incorporating the tree potential and a Fayet–Iliopoulos D-term, the effective potential is minimized at a specific value of l, corresponding to an intermediate mass scale 1011–14 GeV, where the supersymmetry is restored
Avoiding Snow and Ice Formation on Exterior Solar Cell Surfaces – A Review of Research Pathways and Opportunities

AbstractToday energy-efficient and energy-harvesting buildings experience an ever-increasing interest and demand. Building integrated photovoltaics (BIPV) may in this respect represent a powerful and versatile tool for reaching the goal of zero energy and zero emission buildings. The BIPV systems replace the outer building envelope skin, thus serving simultanously as both a climate screen and a power source generating electricity. However, snow and ice formation on the exterior solar cell surfaces reduce their performance and may also lead to faster deterioration. Hence, if one could find a way to develop solar cells which were able to avoid snow and ice formation on their surfaces, one would have moved a large step ahead. This work presents a review exploring miscellaneous pathways for avoiding snow and ice formation on solar cell surfaces including superhydrophobic and icephobic surfaces
Random periodic solutions of SPDEs via integral equations and Wiener–Sobolev compact embedding

AbstractIn this paper, we study the existence of random periodic solutions for semilinear SPDEs on a bounded domain with a smooth boundary. We identify them as the solutions of coupled forward–backward infinite horizon stochastic integral equations on L2(D) in general cases. For this we use Mercerʼs Theorem and eigenvalues and eigenfunctions of the second order differential operators in the infinite horizon integral equations. We then use the argument of the relative compactness of Wiener–Sobolev spaces in C0([0,T],L2(Ω×D)) and generalized Schauderʼs fixed point theorem to prove the existence of a solution of the integral equations. This is the first paper in literature to study random periodic solutions of SPDEs. Our result is also new in finding semi-stable stationary solution for non-dissipative SPDEs, while in literature the classical method is to use the pull-back technique so researchers were only able to find stable stationary solutions for dissipative systems
Effectiveness of exercise therapy: A best-evidence summary of systematic reviews

The purpose of this project was to summarise the available evidence on the effectiveness of exercise therapy for patients with disorders of the musculoskeletal, nervous, respiratory, and cardiovascular systems. Systematic reviews were identified by means of a comprehensive search strategy in 11 bibliographic databases (08/2002), in combination with reference tracking. Reviews that included (i) at least one randomised controlled trial investigating the effectiveness of exercise therapy, (ii) clinically relevant outcome measures, and (iii) full text written in English, German or Dutch, were selected by two reviewers. Thirteen independent and blinded reviewers participated in the selection, quality assessment and data-extraction of the systematic reviews. Conclusions about the effectiveness of exercise therapy were based on the results presented in reasonable or good quality systematic reviews (quality score ≥ 60 out of 100 points). A total of 104 systematic reviews were selected, 45 of which were of reasonable or good quality. Exercise therapy is effective for patients with knee osteoarthritis, sub-acute (6 to 12 weeks) and chronic (≥ 12 weeks) low back pain, cystic fibrosis, chronic obstructive pulmonary disease, and intermittent claudication. Furthermore, there are indications that exercise therapy is effective for patients with ankylosing spondylitis, hip osteoarthritis, Parkinson's disease, and for patients who have suffered a stroke. There is insufficient evidence to support or refute the effectiveness of exercise therapy for patients with neck pain, shoulder pain, repetitive strain injury, rheumatoid arthritis, asthma, and bronchiectasis. Exercise therapy is not effective for patients with acute low back pain. It is concluded that exercise therapy is effective for a wide range of chronic disorders
Classification of solvable Lie algebras with a given nilradical by means of solvable extensions of its subalgebras

AbstractWe construct all solvable Lie algebras with a specific n–dimensional nilradical nn,3 which contains the previously studied filiform (n-2)–dimensional nilpotent algebra nn-2,1 as a subalgebra but not as an ideal. Rather surprisingly it turns out that the classification of such solvable algebras can be deduced from the classification of solvable algebras with the nilradical nn-2,1. Also the sets of invariants of coadjoint representation of nn,3 and its solvable extensions are deduced from this reduction. In several cases they have polynomial bases, i.e. the invariants of the respective solvable algebra can be chosen to be Casimir invariants in its enveloping algebra
η meson production of high-energy nuclear collisions at NLO

AbstractThe transverse momentum spectrum of η meson in relativistic heavy-ion collisions is studied at the Next-to-Leading Order (NLO) within the perturbative QCD, where the jet quenching effect in the QGP is incorporated with the effectively medium-modified η fragmentation functions using the higher-twist approach. We show that the theoretical simulations could give nice descriptions of PHENIX data on η meson in both p+p and central Au + Au collisions at the RHIC, and also provide numerical predictions of η spectra in central Pb + Pb collisions with sNN=2.76 TeV at the LHC. The ratios of η/π0 in p+p and in central Au + Au collisions at 200 GeV are found to overlap in a wide pT region, which matches well the measured ratio η/π0 by PHENIX. We demonstrate that, at the asymptotic region when pT→∞ the ratios of η/π0 in both Au + Au and p+p are almost determined only by quark jets fragmentation and thus approach to the one in e+e− scattering; in addition, the almost identical gluon (quark) contribution fractions to η and to π result in a rather moderate variation of η/π0 distribution at intermediate and high pT region in A+A relative to that in p+p; while a slightly higher η/π0 at small pT in Au + Au can be observed due to larger suppression of gluon contribution fraction to π0 as compared to the one to η. The theoretical prediction for η/π0 at the LHC has also been presented
Influence of nanoscale temperature rises on photoacoustic generation: Discrimination between optical absorbers based on thermal nonlinearity at high frequency

AbstractIn this work, we experimentally investigate thermal-based nonlinear photoacoustic generation as a mean to discriminate between different types of absorbing particles. The photoacoustic generation from solutions of dye molecules and gold nanospheres (same optical densities) was detected using a high frequency ultrasound transducer (20MHz). Photoacoustic emission was observed with gold nanospheres at low fluence for an equilibrium temperature around 4°C, where the linear photoacoustic effect in water vanishes, highlighting the nonlinear emission from the solution of nanospheres. The photoacoustic amplitude was also studied as a function of the equilibrium temperature from 2°C to 20°C. While the photoacoustic amplitude from the dye molecules vanished around 4°C, the photoacoustic amplitude from the gold nanospheres remained significant over the whole temperature range. Our preliminary results suggest that in the context of high frequency photoacoustic imaging, nanoparticles may be discriminated from molecular absorbers based on nanoscale temperature rises
The semiclassical Sobolev orthogonal polynomials: A general approach

AbstractWe say that the polynomial sequence (Qn(λ)) is a semiclassical Sobolev polynomial sequence when it is orthogonal with respect to the inner product 〈p,r〉S=〈u,pr〉+λ〈u,DpDr〉, where u is a semiclassical linear functional, D is the differential, the difference or the q-difference operator, and λ is a positive constant.In this paper we get algebraic and differential/difference properties for such polynomials as well as algebraic relations between them and the polynomial sequence orthogonal with respect to the semiclassical functional u.The main goal of this article is to give a general approach to the study of the polynomials orthogonal with respect to the above nonstandard inner product regardless of the type of operator D considered. Finally, we illustrate our results by applying them to some known families of Sobolev orthogonal polynomials as well as to some new ones introduced in this paper for the first time
Functional and Structural Basis for a Bacteriophage Homolog of Human RAD52

SummaryIn eukaryotes, homologous recombination proteins such as RAD51 and RAD52 play crucial roles in DNA repair and genome stability. Human RAD52 is a member of a large single-strand annealing protein (SSAP) family [1] and stimulates Rad51-dependent recombination [2, 3]. In prokaryotes and phages, it has been difficult to establish the presence of RAD52 homologs with conserved sequences. Putative SSAPs were recently found in several phages that infect strains of Lactococcus lactis [4]. One of these SSAPs was identified as Sak and was found in the virulent L. lactis phage ul36, which belongs to the Siphoviridae family [4, 5]. In this study, we show that Sak is homologous to the N terminus of human RAD52. Purified Sak binds single-stranded DNA (ssDNA) preferentially over double-stranded DNA (dsDNA) and promotes the renaturation of long complementary ssDNAs. Sak also binds RecA and stimulates homologous recombination reactions. Mutations shown to modulate RAD52 DNA binding [6] affect Sak similarly. Remarkably, electron-microscopic reconstruction of Sak reveals an undecameric (11) subunit ring, similar to the crystal structure of the N-terminal fragment of human RAD52 [7, 8]. For the first time, we propose a viral homolog of RAD52 at the amino acid, phylogenic, functional, and structural levels
Investigating the Glucagon Receptor and Glucagon-Like Peptide 1 Receptor Activity of Oxyntomodulin-Like Analogues in Male Wistar Rats

AbstractAimsTo investigate the effect of Glu-3 OXM-like analogues on food intake and bodyweight in male rats.BackgroundOxyntomodulin (OXM) is a natural agonist at both the glucagon receptor (GCGr) and the glucagon-like peptide 1 receptor (GLP-1r), and peripheral administration reduces food intake and increases energy expenditure in rodents and humans. Substituting the native glutamine (Gln) at amino acid position 3 of OXM for glutamate (Glu) has previously been shown to diminish GCGr activity without affecting GLP-1r activity. The effects of Glu-3 OXM analogues have not been investigated in rats.MethodsThe effect of 2 Glu-3-substituted OXM-like analogues (eg, OXM14E3 and OXM15E3) on food intake and body weight was investigated in male Wistar rats during 6 days of daily subcutaneous (SC) administration. The effects of Glu-3 substitution on analogue binding and activity at the rat GCGr and rat GLP-1 receptor were investigated in vitro using Chinese hamster ovary or Chinese hamster lung cells.ResultsWe report the novel finding that 2 5-nmol/kg Glu-3 OXM-like analogues (OXM14E3 and OXM15E3) significantly increased rat body weight by up to 4% compared with the equivalent non-Glu-3 analogues (OXM14 and OXM15), without affecting food intake. The effect of OXM15E3 on body weight was dose–dependent. Glu-3 analogues, including Glu-3 OXM, decreased glucagon-mediated cyclic adenosine monophosphate accumulation in Chinese hamster ovary cells expressing the rat GCGr, suggesting they may be acting as antagonists.ConclusionsThe results indicate Glu-3 OXM-like analogues might not be suitable tools to investigate the mechanism of OXM analogue action in a rat model because they significantly increase body weight independent of food intake. Glu-3 OXM analogues are partial agonists at the rat GCGr and may also act as antagonists, possibly resulting in the observed increase in body weight