pinecone/core-2020-05-10-deduplication huggingface dataset:
The influence of inertia and contact angle on the instability of partially wetting liquid strips: A numerical analysis study

The stability of a thread of fluid deposited on a flat solid substrate is studied numerically by means of the Finite Element Method in combination with an Arbitrary Lagrangian-Eulerian technique. A good agreement is observed when our results are compared with predictions of linear stability analysis obtained by other authors. Moreover, we also analysed the influence of inertia for different contact angles and found that inertia strongly affects the growth rate of the instability when contact angles are large. By contrast, the wave number of the fastest growing mode does not show important variations with inertia. The numerical technique allows us to follow the evolution of the free surface instability until comparatively late stages, where the filament begins to break into droplets. The rupture pattern observed for several cases shows that the number of principal droplets agrees reasonably well with an estimation based on the fastest growing modes.Fil: Ubal, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaFil: Grassia, Paul. University Of Manchester; Reino UnidoFil: Campana, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Giavedoni, Maria Delia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaFil: Saita, Fernando Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentin
Distinct functions of alternatively spliced isoforms encoded by zebrafish mef2ca and mef2cb

AbstractIn mammals, an array of MEF2C proteins is generated by alternative splicing (AS), yet specific functions have not been ascribed to each isoform. Teleost fish possess two MEF2C paralogues, mef2ca and mef2cb. In zebrafish, the Mef2cs function to promote cardiomyogenic differentiation and myofibrillogenesis in nascent skeletal myofibers. We found that zebrafish mef2ca and mef2cb are alternatively spliced in the coding exons 4–6 region and these splice variants differ in their biological activity. Of the two, mef2ca is more abundantly expressed in developing skeletal muscle, its activity is tuned through zebrafish development by AS. By 24hpf, we found the prevalent expression of the highly active full length protein in differentiated muscle in the somites. The splicing isoform of mef2ca that lacks exon 5 (mef2ca 4–6), encodes a protein that has 50% lower transcriptional activity, and is found mainly earlier in development, before muscle differentiation. mef2ca transcripts including exon 5 (mef2ca 4–5–6) are present early in the embryo. Over-expression of this isoform alters the expression of genes involved in early dorso-ventral patterning of the embryo such as chordin, nodal related 1 and goosecoid, and induces severe developmental defects. AS of mef2cb generates a long splicing isoform in the exon 5 region (Mef2cbL) that predominates during somitogenesis. Mef2cbL contains an evolutionarily conserved domain derived from exonization of a fragment of intron 5, which confers the ability to induce ectopic muscle in mesoderm upon over-expression of the protein. Taken together, the data show that AS is a significant regulator of Mef2c activity
Item transformation for computer assisted language testing: The adaptation of the Spanish University entrance examination

AbstractSince the Spanish Educational system is changing and promoting the use of online tests, it was necessary to study the transformation of test items in the “Spanish University Entrance Examination” (IB P.A.U.) to diminish the effect of test delivery changes (through its computerization) in order to affect the least the current model. The purpose of this study was to describe and suggest the properties of a new test item taxonomy for the Spanish University Entrance Examination. After a convenient study and piloting by using previous research in computer-based language testing, the researchers created a taxonomy of test items for the I.B. P.A.U
Self-dual supergravity in seven dimensions with reduced holonomy G2

AbstractWe present self-dual N=2 supergravity in superspace for Euclidean seven dimensions with the reduced holonomy G2⊂SO(7), including all higher-order terms. As its foundation, we first establish N=2 supergravity without self-duality in Euclidean seven dimensions. We next show how the generalized self-duality in terms of octonion structure constants can be consistently imposed on the superspace constraints. We found two self-dual N=2 supergravity theories possible in 7D, depending on the representations of the two spinor charges of N=2. The first formulation has both of the two spinor charges in the 7 of G2 with 24+24 on-shell degrees of freedom. The second formulation has both charges in the 1 of G2 with 16+16 on-shell degrees of freedom
Manufacturing doubt about endocrine disrupter science – A rebuttal of industry-sponsored critical comments on the UNEP/WHO report “State of the Science of Endocrine Disrupting Chemicals 2012”

AbstractWe present a detailed response to the critique of “State of the Science of Endocrine Disrupting Chemicals 2012” (UNEP/WHO, 2013) by financial stakeholders, authored by Lamb et al. (2014). Lamb et al.'s claim that UNEP/WHO (2013) does not provide a balanced perspective on endocrine disruption is based on incomplete and misleading quoting of the report through omission of qualifying statements and inaccurate description of study objectives, results and conclusions. Lamb et al. define extremely narrow standards for synthesizing evidence which are then used to dismiss the UNEP/WHO 2013 report as flawed. We show that Lamb et al. misuse conceptual frameworks for assessing causality, especially the Bradford–Hill criteria, by ignoring the fundamental problems that exist with inferring causality from empirical observations. We conclude that Lamb et al.'s attempt of deconstructing the UNEP/WHO (2013) report is not particularly erudite and that their critique is not intended to be convincing to the scientific community, but to confuse the scientific data. Consequently, it promotes misinterpretation of the UNEP/WHO (2013) report by non-specialists, bureaucrats, politicians and other decision makers not intimately familiar with the topic of endocrine disruption and therefore susceptible to false generalizations of bias and subjectivity
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

SummaryMitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and other cofactors. This is accompanied by fragmentation of the organelle and remodeling of the cristae. Here we provide evidence that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion. OPA1 does not interfere with activation of the mitochondrial “gatekeepers” BAX and BAK, but it controls the shape of mitochondrial cristae, keeping their junctions tight during apoptosis. Tightness of cristae junctions correlates with oligomerization of two forms of OPA1, a soluble, intermembrane space and an integral inner membrane one. The proapoptotic BCL-2 family member BID, which widens cristae junctions, also disrupts OPA1 oligomers. Thus, OPA1 has genetically and molecularly distinct functions in mitochondrial fusion and in cristae remodeling during apoptosis
Search for FCNC single top-quark production at s=7 TeV with the ATLAS detector

AbstractA search for the production of single top-quarks via flavour-changing neutral-currents is presented. Data collected with the ATLAS detector at a centre-of-mass energy of s=7 TeV, corresponding to an integrated luminosity of 2.05 fb−1, are used. Candidate events with a semileptonic top-quark decay signature are classified as signal- or background-like events by using several kinematic variables as input to a neural network. No signal is observed in the neural network output distribution and a Bayesian upper limit is placed on the production cross-section. The observed upper limit at 95% confidence level on the cross-section multiplied by the t→Wb branching fraction is measured to be σqg→t×B(t→Wb)<3.9 pb. This upper limit is converted using a model-independent approach into upper limits on the coupling strengths κugt/Λ<6.9⋅10−3 TeV−1 and κcgt/Λ<1.6⋅10−2 TeV−1, where Λ is the new physics scale, and on the branching fractions B(t→ug)<5.7⋅10−5 and B(t→cg)<2.7⋅10−4
A density-matching approach for optimization under uncertainty

AbstractModern computers enable methods for design optimization that account for uncertainty in the system—so-called optimization under uncertainty (OUU). We propose a metric for OUU that measures the distance between a designer-specified probability density function of the system response (the target) and the system response’s density function at a given design. We study an OUU formulation that minimizes this distance metric over all designs. We discretize the objective function with numerical quadrature, and we approximate the response density function with a Gaussian kernel density estimate. We offer heuristics for addressing issues that arise in this formulation, and we apply the approach to a CFD-based airfoil shape optimization problem. We qualitatively compare the density-matching approach to a multi-objective robust design optimization to gain insight into the method
Capgras syndrome as a psychiatric manifestation in Parkinson's disease: A case report and literature review

AbstractWe present the case of a 58-year-old male patient who had symptoms of anxiety after witnessing a case of social violence in his community in 2005. After that, he presented symptoms of Parkinson Disease and in 2006 we established this as the main diagnosis. In 2009 he presented neuropsychiatric symptoms such as apathy, anhedonia, social isolation, blunted affect, visual and auditory hallucinations, paranoid delusions, soliloquies, and the false belief that his wife and daughter had been replaced by identical impostors. We established the diagnosis of Capgras Syndrome. This case is clinically relevant because of the presentation of its symptoms, its evolution and its presenting comorbidity
Fractional variational problems with the Riesz–Caputo derivative

AbstractIn this paper we investigate optimality conditions for fractional variational problems, with a Lagrangian depending on the Riesz–Caputo derivative. First we prove a generalized Euler–Lagrange equation for the case when the interval of integration of the functional is different from the interval of the fractional derivative. Next we consider integral dynamic constraints on the problem, for several different cases. Finally, we determine optimality conditions for functionals depending not only on the admissible functions, but on time also, and we present a necessary condition for a pair function-time to be an optimal solution to the problem
Logarithmic speeds for one-dimensional perturbed random walks in random environments

AbstractWe study the random walk in a random environment on Z+={0,1,2,…}, where the environment is subject to a vanishing (random) perturbation. The two particular cases that we consider are: (i) a random walk in a random environment perturbed from Sinai’s regime; (ii) a simple random walk with a random perturbation. We give almost sure results on how far the random walker is from the origin, for almost every environment. We give both upper and lower almost sure bounds. These bounds are of order (logt)β, for β∈(1,∞), depending on the perturbation. In addition, in the ergodic cases, we give results on the rate of decay of the stationary distribution
Practice and assessment of oral skills in developing online preparatory materials through the InGenio authoring shell

AbstractThe practice of oral skills is a basic requirement of learning or teaching a new language, as one of the main goals in the field of language learning is developing oral communicative competence, especially needed in contexts where the students’ L2 is the vehicular language and therefore the main means of interaction. The InGenio online authoring tool allows designers of new materials, as well as language teachers and students, to rethink and imagine new ways of dealing with practice and assessment of listening and speaking skills thanks to the flexibility of its templates, resources and tools. This article explores the ways in which the InGenio utilities, solutions and learning materials are being expanded and updated in order to address oral practice and assessment in a more efficient and effective manner making the most of these improvements to provide new learning opportunities
Probing f(R) cosmology with sterile neutrinos via measurements of scale-dependent growth rate of structure

AbstractIn this paper, we constrain the dimensionless Compton wavelength parameter B0 of f(R) gravity as well as the mass of sterile neutrino by using the cosmic microwave background observations, the baryon acoustic oscillation surveys, and the linear growth rate measurements. Since both the f(R) model and the sterile neutrino generally predict scale-dependent growth rates, we utilize the growth rate data measured in different wavenumber bins with the theoretical growth rate approximatively scale-independent in each bin. The employed growth rate data come from the peculiar velocity measurements at z=0 in five wavenumber bins, and the redshift space distortions measurements at z=0.25 and z=0.37 in one wavenumber bin. By constraining the f(R) model alone, we get a tight 95% upper limit of log10⁡B0<−4.1. This result is slightly weakened to log10⁡B0<−3.8 (at 2σ level) once we simultaneously constrain the f(R) model and the sterile neutrino mass, due to the degeneracy between the parameters of the two. For the massive sterile neutrino parameters, we get the effective sterile neutrino mass mν,sterileeff<0.62 eV (2σ) and the effective number of relativistic species Neff<3.90 (2σ) in the f(R) model. As a comparison, we also obtain mν,sterileeff<0.56 eV (2σ) and Neff<3.92 (2σ) in the standard ΛCDM model
Effects of habituation, research and ecotourism on faecal glucocorticoid metabolites in wild western lowland gorillas: Implications for conservation management

AbstractWildlife tourism is proliferating worldwide and has the potential to raise revenue for conservation as well as public awareness of conservation issues. However, concerns are growing about the potentially negative influence of such tourism on the wildlife involved. We investigate the effects of habituation, ecotourism and research activities on levels of faecal glucocorticoid metabolites (FGCMs), a proxy for physiological stress, in wild western lowland gorillas (Gorilla gorilla gorilla) in the Central African Republic. We compare FGCMs in three human-contacted groups with those in unhabituated gorillas. We also explore how human–gorilla contact influences FGCMs of a gorilla group undergoing habituation and investigate how measures of general human–gorilla contact, tourism and human proximity influence FGCMs in recently and long-term habituated groups. Two of the three human-contacted groups had higher levels of FGCMs than unhabituated gorillas. The group undergoing habituation had the highest FGCMs, which increased up to 21days following contacts, suggesting a cumulative FGCM response, in line with descriptions of a hormonal adaptation response to a chronic intermittent stressor. FGCMs in habituated groups were significantly associated with increasing frequency of violation of the 7m distance rule by observers and with a medical intervention but not with other measures of human pressure. Our findings provide critical information for the management of this, and other, species whose conservation depends on habituation for ecotourism
Searching for the dimension of valued preference relations

AbstractThe more information a preference structure gives, the more sophisticated representation techniques are necessary, so decision makers can have a global view of data and therefore a comprehensive understanding of the problem they are faced with. In this paper we propose to explore valued preference relations by means of a search for the number of underlying criteria allowing its representation in real space. A general representation theorem for arbitrary crisp binary relations is obtained, showing the difference in representation between incomparability––related to the intersection operator––and other inconsistencies––related to the union operator. A new concept of dimension is therefore proposed, taking into account inconsistencies in source of information. Such a result is then applied to each α-cut of valued preference relations
Coarse version of the Banach–Stone theorem

AbstractWe show that if there exists a Lipschitz homeomorphism T between the nets in the Banach spaces C(X) and C(Y) of continuous real valued functions on compact spaces X and Y, then the spaces X and Y are homeomorphic provided l(T)×l(T−1)<65. By l(T) and l(T−1) we denote the Lipschitz constants of the maps T and T−1. This improves the classical result of Jarosz and the recent result of Dutrieux and Kalton where the constant obtained is 1716. We also estimate the distance of the map T from the isometry of the spaces C(X) and C(Y)
An analysis of Ruspini partitions in Gödel logic

AbstractBy a Ruspini partition we mean a finite family of fuzzy sets {f1,…,fn},fi:[0,1]→[0,1], such that ∑i=1nfi(x)=1 for all x∈[0,1], where [0,1] denotes the real unit interval. We analyze such partitions in the language of Gödel logic. Our first main result identifies the precise degree to which the Ruspini condition is expressible in this language, and yields inter alia a constructive procedure to axiomatize a given Ruspini partition by a theory in Gödel logic. Our second main result extends this analysis to Ruspini partitions fulfilling the natural additional condition that each fi has at most one left and one right neighbour, meaning that minx∈[0,1]{fi1(x),fi2(x),fi3(x)}=0 holds for i1≠i2≠i3
Soil–plant interactions and the uptake of Pb at abandoned mining sites in the Rookhope catchment of the N. Pennines, UK — A Pb isotope study

AbstractThis paper examines Pb concentrations and sources in soil, grass and heather from the Rookhope catchment in the North Pennines, UK, an area of historical Pb and Zn mining and smelting. Currently, the area has extensive livestock and sports shooting industries. Risk assessment, using the source-pathway-receptor paradigm, requires the quantification of source terms and an understanding of the many factors determining the concentration of Pb in plants. A paired soil and vegetation (grass and heather) geochemical survey was undertaken. Results showed no direct correlation between soil (total or EDTA extractable Pb) and vegetation Pb concentration. However, regression modelling based on the Free-Ion Activity Model (FIAM) suggested that the underlying mechanism determining grass Pb concentration across the catchment was largely through root uptake. Spatial patterns of 206/207Pb isotopes suggested greater aerosol deposition of Pb on high moorland and prevailing wind facing slopes. This was evident in the isotopic ratios of the heather plants. Pb isotope analysis showed that new growth heather tips typically had 206/207Pb values of ~1.14, whilst grass shoots typically had values ~1.16 and bulk soil and peat ~1.18. However, the 206/207Pb ratio in the top few cm of peat was ~1.16 suggesting that grass was accessing Pb from a historical/recent pool of Pb in soil/peat profiles and consisting of both Pennine ore Pb and long-range Pb deposition. Isotope Dilution assays on the peat showed a lability of between 40 and 60%. A simple source apportionment model applied to samples where the isotope ratios was not within the range of the local Pennine Pb, suggested that grass samples contained up to 31% of non-Pennine Pb. This suggests that the historical/recent reservoir of non-Pennine Pb accessed by roots continues to be a persistent contaminant source despite the principal petrol Pb source being phased out over a decade ago
Using a shallow linguistic kernel for drug–drug interaction extraction

AbstractA drug–drug interaction (DDI) occurs when one drug influences the level or activity of another drug. Information Extraction (IE) techniques can provide health care professionals with an interesting way to reduce time spent reviewing the literature for potential drug–drug interactions. Nevertheless, no approach has been proposed to the problem of extracting DDIs in biomedical texts. In this article, we study whether a machine learning-based method is appropriate for DDI extraction in biomedical texts and whether the results provided are superior to those obtained from our previously proposed pattern-based approach [1]. The method proposed here for DDI extraction is based on a supervised machine learning technique, more specifically, the shallow linguistic kernel proposed in Giuliano et al. (2006) [2]. Since no benchmark corpus was available to evaluate our approach to DDI extraction, we created the first such corpus, DrugDDI, annotated with 3169 DDIs. We performed several experiments varying the configuration parameters of the shallow linguistic kernel. The model that maximizes the F-measure was evaluated on the test data of the DrugDDI corpus, achieving a precision of 51.03%, a recall of 72.82% and an F-measure of 60.01%.To the best of our knowledge, this work has proposed the first full solution for the automatic extraction of DDIs from biomedical texts. Our study confirms that the shallow linguistic kernel outperforms our previous pattern-based approach. Additionally, it is our hope that the DrugDDI corpus will allow researchers to explore new solutions to the DDI extraction problem
On dynamical realizations of l-conformal Galilei and Newton–Hooke algebras

AbstractIn two recent papers (Aizawa et al., 2013 [15]) and (Aizawa et al., 2015 [16]), representation theory of the centrally extended l-conformal Galilei algebra with half-integer l has been applied so as to construct second order differential equations exhibiting the corresponding group as kinematical symmetry. It was suggested to treat them as the Schrödinger equations which involve Hamiltonians describing dynamical systems without higher derivatives. The Hamiltonians possess two unusual features, however. First, they involve the standard kinetic term only for one degree of freedom, while the remaining variables provide contributions linear in momenta. This is typical for Ostrogradsky's canonical approach to the description of higher derivative systems. Second, the Hamiltonian in the second paper is not Hermitian in the conventional sense. In this work, we study the classical limit of the quantum Hamiltonians and demonstrate that the first of them is equivalent to the Hamiltonian describing free higher derivative nonrelativistic particles, while the second can be linked to the Pais–Uhlenbeck oscillator whose frequencies form the arithmetic sequence ωk=(2k−1), k=1,…,n. We also confront the higher derivative models with a genuine second order system constructed in our recent work (Galajinsky and Masterov, 2013 [5]) which is discussed in detail for l=32