pinecone/core-2020-05-10-deduplication huggingface dataset:
Premedication for neonatal endotracheal intubation: results from the epidemiology of procedural pain in neonates study.

International audienceOBJECTIVES: To describe the frequency and nature of premedications used prior to neonatal endotracheal intubation; to confront observed practice with current recommendations; and to identify risk factors for the absence of premedication. DESIGN, SETTING, AND PATIENTS: Data concerning intubations were collected prospectively at the bedside as part of an observational study collecting around-the-clock data on all painful or stressful procedures performed in neonates during the first 14 days of their admission to 13 tertiary care units in the region of Paris, France, between 2005 and 2006. INTERVENTION: Observational study. MEASUREMENTS AND MAIN RESULTS: Specific premedication prior to endotracheal intubation was assessed. Ninety one intubations carried out on the same number of patients were analyzed. The specific premedication rate was 56% and included mostly opioids (67%) and midazolam (53%). Compared with recent guidance from the American Academy of Pediatrics, used premedications could be classified as "preferred" (12%), "acceptable" (18%), "not recommended" (27%), and "not described" (43%). In univariate analysis, infants without a specific premedication compared with others were younger at the time of intubation (median age: 0.7 vs. 2.0 days), displayed significantly more frequent spontaneous breathing at the time of intubation (31% vs. 12%) and a higher percentage of analgesia for all other painful procedures (median values: 16% vs. 6%). In multivariate analysis, no factor remained statistically significant. CONCLUSIONS: Premedication use prior to neonatal intubation was not systematically used and when used it was most frequently inconsistent with recent recommendations. No patient- or center-related independent risk factor for the absence of premedication was identified in this study
Oxidation kinetics of Ni metallic films: formation of NiO-based resistive switching structures

International audienceResistive switching controlled by external voltage has been reported in many Metal/Resistive oxide/Metal (MRM) structures in which the resistive oxide was simple transition metal oxide thin films such as NiO or TiO2 deposited by reactive sputtering. In this paper, we have explored the possibility to form NiO-based MRM structures from the partial oxidation of a blanket Ni metallic film using a Rapid Thermal Annealing route, the remaining Ni layer being used as bottom electrode. X-ray diffraction was used to apprehend the Ni oxidation kinetics while transmission electron microscopy enabled investigating local microstructure and film interfaces. These analyses have especially emphasized the predominant role of the asdeposited Ni metallic film microstructure (size and orientation of crystallites) on (i) oxidation kinetics, (ii) NiO film microstructural characteristics (crystallite size, texture and interface roughness) and (iii) subsequent electrical behavior. On this latter point, the as-grown NiO films were initially in the low resistance ON state without the electro-forming step usually required for sputtered films. Above the threshold voltage varying from 2 to 5 V depending on oxidation conditions, the Pt/NiO/Ni MRM structures irreversibly switched into the high resistance OFF state. This irreversibility is thought to originate in the microstructure of the NiO films that would cause the difficulty to re-form conductive paths
Besov regularity and new error estimates for finite volume approximations of the p-laplacian

In a previous work, we have constructed a family of finite volume schemes on rectangular meshes for the p-laplacian and we proved error estimates in case the exact solution lies in $W^{2,p}$. Actually, $W^{2,p}$ is not a natural space for solutions of the p-laplacian in the case $p>2$. Indeed, for general $L^{p\'}$ data it can be shown that the solution only belongs to the Besov space $B^{1+\\frac{1}{p-1},p}_\\infty$. In this paper, we prove Besov kind a priori estimates on the approximate solution for any data in $L^{p\'}$. We then obtain new error estimates for such solutions in the case of uniform meshes
Quantification of water content and speciation in natural silicic glasses (phonolite, dacite, rhyolite) by confocal microRaman spectrometry

International audienceThe determination of total water content (H2OT: 0.1-10 wt%) and water speciation (H2Omolecular/OH) in volcanic products by confocal microRaman spectrometry are discussed for alkaline (phonolite) and calcalkaline (dacite and rhyolite) silicic glasses. Shape and spectral distribution of the total water band (H2OT) at not, vert, similar3550 cm−1 show systematic evolution with glass H2OT, water speciation and NBO/T. In the studied set of silicic samples, calibrations based on internal normalization of the H2OT band to a band related to vibration of aluminosilicate network (TOT) at not, vert, similar490 cm−1 vary with glass peraluminosity. An external calibration procedure using well-characterized glass standards is less composition-dependent and provides excellent linear correlation between total dissolved water content and height or area of the H2OT Raman band. Accuracy of deconvolution procedure of the H2OT band to quantify water speciation in water-rich and depolymerized glasses depends on the strength of OH hydrogen bonding. System confocal performance, scattering from embedding medium and glass microcrystallinity have a crucial influence on accuracy of Raman analyses of water content in glass-bearing rocks and melt inclusions in crystals
AMBER/VLTI interferometric observations of the recurrent Nova RS Ophiuchii 5.5 days after outburst

International audienceAims.We report on spectrally dispersed interferometric AMBER/VLTI observations of the recurrent nova RS Oph five days after the discovery of its outburst on 2006 Feb. 12. Methods: Using three baselines ranging from 44 to 86 m, and a spectral resolution of λ/δλ=1500, we measured the extension of the milliarcsecond-scale emission in the K band continuum and in the Brγ and He I 2.06 μm lines, allowing us to get an insight into the kinematics of the line forming regions. The continuum visibilities were interpreted by fitting simple geometric models consisting of uniform and Gaussian ellipses, ring and binary models. The visibilities and differential phases in the Brγ line were interpreted using skewed ring models aiming to perform a limited parametric reconstruction of the extension and kinematics of the line forming region. Results: The limited uv coverage does not allow discrimination between filled models (uniform or Gaussian ellipses) and rings. Binary models are discarded because the measured closure phase in the continuum is close to zero. The visibilities in the lines are at a low level compared to their nearby continuum, consistent with a more extended line forming region for He I 2.06 μm than Brγ. The ellipse models for the continuum and for the lines are highly flattened (b/a˜0.6) and share the same position angle (PA˜140°). Their typical Gaussian extensions are 3.1×1.9 mas, 4.9×2.9 mas and 6.3×3.6 mas for the continuum, Brγ and He I 2.06 μm lines, respectively. Two radial velocity fields are apparent in the Brγ line: a slow expanding ring-like structure (v_rad≤1800 km s-1), and a fast structure extended in the E-W direction (v_rad˜ 2500{-}3000 km s-1), a direction that coincides with the jet-like structure seen in the radio. These results confirm the basic fireball model, contrary to the conclusions of other interferometric observations conducted by Monnier et al. (2006a, ApJ, 647, L127). Based on observations collected at the European Southern Observatory, Paranal, Chile, within the programme 276.D-5049
Combining Topological Maps, Multi-Label Simple Points, and Minimum-Length Polygons for Efficient Digital Partition Model

International audienceDeformable models have shown great potential for image segmentation. They include discrete models whose combinatorial formulation leads to efficient and sometimes optimal minimization algorithms. In this paper, we propose a new discrete framework to deform any partition while preserving its topology. We show how to combine the use of multi-label simple points, topological maps and minimum-length polygons in order to implement an efficient digital deformable partition model. Our experimental results illustrate the potential of our framework for segmenting images, since it allows the mixing of region-based, contour-based and regularization energies, while keeping the overall image structure
LEAD ISOTOPIC COMPOSITIONS IN THE EPICA DOME C ICE CORE AND SOUTHERN HEMISPHERE POTENTIAL SOURCE AREAS

A record of Pb isotopic compositions and Pb and Ba concentrations are presented for the EPICA Dome C ice core covering the past 220 ky, indicating the characteristics of dust and volcanic Pb deposition in central East Antarctica. Lead isotopic compositions are also reported in a suite of soil and loess samples from the Southern Hemisphere (Australia, Southern Africa, Southern South America, New Zealand, Antarctica) in order to evaluate the provenance of dust present in Antarctic ice. Lead isotopic compo-sitions in Dome C ice support the contention that Southern South America was an important source of dust in Antarctica during the last two glacial maxima, and furthermore suggest occasional dust contri-butions from local Antarctic sources. The isotopic signature of Pb in Antarctic ice is altered by the presence of volcanic Pb, inhibiting the evaluation of glacial–interglacial changes in dust sources and the evaluation of Australia as a source of dust to Antarctica. Consequently, an accurate evaluation of the predominant source(s) of Antarctic dust can only be obtained from glacial maxima, when dust-Pb concentrations were greatest. These data confirm that volcanic Pb is present throughout Antarctica and is emitted in a physical phase that is free from Ba, while dust Pb is transported within a matrix containing Ba and other crustal element
Strongly subluminal regime of optical-to-terahertz conversion in GaP

We introduce and investigate a special regime of terahertz generation in electro-optic crystals with
	ultrashort laser pulses, in which neither phase-matching nor Cherenkov radiation mechanism are
	efficient. This regime occurs under the conditions that the optical group refractive index is larger
	than the low-frequency phase refractive index of the crystal, and the spectral bandwidth of the laser
	pulse is smaller than the frequency of the phase-matched terahertz wave. In this regime, that can be
	realized for a Ti:sapphire laser in GaP, terahertz generation is provided by transient processes at the
	crystal boundaries. We study the peculiarities of the terahertz emission from a slab of GaP excited
	with a Ti:sapphire laser. In particular, we demonstrate a possibility to implement a pointlike source
	of terahertz radiation that can increase the resolution of terahertz apertureless near-field microscopy
Novel transcript profiling of diffuse alveolar damage induced by hyperoxia exposure in mice: Normalization by glyceraldehyde 3-phosphate dehydrogenase

Under mechanical ventilation with high-inspired oxygen concentration, diffuse
	alveolar damage (DAD) was found to take place in some patients. To clarify the
	molecular pathophysiology of this condition we investigated the time course of gene
	expression changes induced by hyperoxia exposure in mouse lung using real-time
	quantitative polymerase chain reaction (real-time qPCR). Our results normalized by
	glyceraldehyde 3-phosphate dehydrogenase showed that mRNA levels of cysteine rich
	protein 61 (CYR61) and connective tissue growth factor (CTGF) were significantly
	up-regulated, while those of surfactant-associated protein C (SFTPC), cytochrome
	P450, 2F2 (CYP2F2), Claudin 1, (CLDN1), membrane-associated zonula occludens
	protein-1 (ZO-1), lysozyme (LYZS), and P lysozyme structural (LZP-S) were
	significantly down-regulated. Increasing level of mRNAs, each encoding CYR61 and
	CTGF, suggests a serious risk of fibrosing alveolitis. Decrease in levels of mRNAs for
	SFTPC, CYP2F2, CLDN1, ZO-1, LYZS, and LZP-S suggests alveolar dysfunction
	and disruption of the immune system. Moreover we confirmed apoptotic conditions,
	such as significant up-regulations of mRNA levels in Myc and Galectin-3. Hyperoxic
	condition probably yielded reactive oxygen species (ROS), which resulted in a malignant cycle of ROS production by Myc overexpression
MEG analysis of neural dynamics in attention-deﬁcit/hyperactivity disorder with fuzzy entropy

Producción CientíficaThe aim of this study was to analyze the neural dynamics in attention-deficit/hyperactivity disorder (ADHD). For this purpose, magnetoencephalographic (MEG) background activity was analyzed using fuzzy entropy (FuzzyEn), an entropy measure that quantifies signal irregularity, in 13 ADHD patients and 14 control children. Additionally, relative power (RP) was computed in conventional frequency bands (delta, theta, alpha, beta and gamma). FuzzyEn results showed that MEG activity was more regular in ADHD patients than in controls. Moreover, we found an increase of power in delta band and a decrease in the remaining frequency bands. Statistically significant differences (p-values <0.05; nonparametric permutation test for multiple comparisons) were detected for FuzzyEn in the posterior and left temporal regions, and for RP in the posterior, anterior and left temporal regions. Our results support the hypothesis that ADHD involves widespread functional brain abnormalities, affecting more areas than fronto-striatal circuits, such as the left temporal and posterior regions.Ministerio de Economía y Competitividad (project TEC2011-22987)Junta de Castilla y León (project BIO/VA38/14 and project VA059U13
Editorial on "Multiplex networks: Structure, dynamics and applications"

There is a wide range of systems in the real world where components cannot function independently, so that these components interact with others through different channels of connectivity and dependencies. Complex Networks theory is, in fact, the formal tool for describing and analyzing fields as disparate as sociology (social networks, acquaintances or collaborations between individuals), biology (metabolic and protein networks, neural networks) or technology (phone call networks, computers in telecommunication networks
Cross-sectional and plan-view cathodoluminescence of GaN partially coalesced above a nanocolumn array

The optical properties of GaN layers coalesced above an array of nanocolumns have important consequences for advanced optoelectronic devices. GaN nanocolumns coalesced using a nanoscale epitaxial overgrowth technique have been investigated by high resolution cathodoluminescence (CL) hyperspectral imaging. Plan-view microscopy reveals partially coalesced GaN layers with a sub-μm scale domain structure and distinct grain boundaries, which is mapped using CL spectroscopy showing high strain at the grain boundaries. Cross-sectional areas spanning the partially coalesced GaN and underlying nanocolumns are mapped using CL, revealing that the GaN bandedge peak shifts by about 25 meV across the partially coalesced layer of ∼2 μm thick. The GaN above the nanocolumns remains under tensile strain, probably due to Si out-diffusion from the mask or substrate. The cross-sectional data show how this strain is reduced towards the surface of the partially coalesced layer, possibly due to misalignment between adjacent partially coalesced regions
Material selection for spallation neutron source windows. Application to PDS-XADS and XT-ADS prototypes

High performance neutron sources are being proposed for many scientific and industrial applications, ranging from material studies, hybrid reactors and transmutation of nuclear wastes. In the case of transmutation of nuclear wastes, accelerator driven systems (ADS) are considered as one of the main technical options for such purpose. In ADS a high performance spallation neutron source becomes an essential element for its operation and control. This spallation source must fulfil very challenging nuclear and thermo-mechanical requirements, because of the high neutron rates needed in ADS. The material selection for this key component becomes of paramount importance, particularly the source window that separates the vacuum accelerator tube from the spallation material where the accelerated protons impinge. In this paper, an integral analysis of spallation sources is done, taking as a reference the projects in this field proposal in the framework of European projects. Our analysis and calculations show that titanium and vanadium alloys are more suitable than steel as structural material for an industrial ADS beam window, mostly due to its irradiation damage resistance
Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury.

Cognitive processes require a functional interaction between specialized multiple, local and remote brain regions. Although these interactions can be strongly altered by an acquired brain injury, brain plasticity allows network reorganization to be principally responsible for recovery. The present work evaluates the impact of brain injury on functional connectivity patterns. Networks were calculated from resting-state magnetoencephalographic recordings from 15 brain injured patients and 14 healthy controls by means of wavelet coherence in standard frequency bands. We compared the parameters defining the network, such as number and strength of interactions as well as their topology, in controls and patients for two conditions: following a traumatic brain injury and after a rehabilitation treatment. A loss of delta- and theta-based connectivity and conversely an increase in alpha- and beta-band-based connectivity were found. Furthermore, connectivity parameters approached controls in all frequency bands, especially in slow-wave bands. A correlation between network reorganization and cognitive recovery was found: the reduction of delta-band-based connections and the increment of those based on alpha band correlated with Verbal Fluency scores, as well as Perceptual Organization and Working Memory Indexes, respectively. Additionally, changes in connectivity values based on theta and beta bands correlated with the Patient Competency Rating Scale. The current study provides new evidence of the neurophysiological mechanisms underlying neuronal plasticity processes after brain injury, and suggests that these changes are related with observed changes at the behavioural leve
Carbon based substrates for interfacing neurons: Comparing pristine with functionalized carbon nanotubes effects on cultured neuronal networks

Pristine (as prepared) carbon nanotube (CNT) based substrates have been widely used to grow and interface neurons in culture. Nerve cells normally differentiate on CNTs and the synaptic networks, newly formed at the interface with this material, usually show an improved robustness in signal transfer. However manipulation of pristine CNTs is often prevented by their low dispersibility and tendency to aggregate in most solvents. This issue can be at least partially solved by adding solubilizing groups to the surface of CNT, which also helps improving their biocompatibility. It becomes therefore of crucial importance to determine whether chemically manipulated CNTs may maintain their performance in improving nerve signaling. Here we study and compare the impact in vitro on neuronal signaling of two classes of chemically modified multiwalled CNTs in reference to pristine CNTs, which are known to be a substrate able to boost neuronal growth and communication. We found that the extent of functionalization and the nature of the functional groups on MWNT sidewalls affect the conductivity and the biological effects of the final derivatives. This information is important for the future design of biointegrated devices
An ontology-based approach for modelling architectural styles

The conceptual modelling of software architectures is of central importance for the quality of a software system. A rich modelling language is required to integrate the different aspects of architecture modelling, such as architectural styles, structural and behavioural modelling,\ud
into a coherent framework.We propose an ontological approach for architectural style modelling based on description logic as an abstract, meta-level modelling instrument. Architectural styles are often neglected in software architectures. We introduce a framework for style definition and style combination. The link between quality requirements and conceptual modelling of architectural styles is investigated. The application of the ontological framework in the form of an integration into existing\ud
architectural description notations such as ACME and UML-based approaches, and also service ontologies is illustrated
Water droplet accumulation and motion in PEM (Proton Exchange Membrane) fuel cell mini-channels

Effective water management is one of the key strategies for improving low temperature Proton Exchange Membrane (PEM) fuel cell performance and durability. Phenomena such as membrane dehydration, catalyst layer flooding, mass transport and fluid flow regimes can be affected by the interaction, distribution and movement of water in flow plate channels.\ud
In this paper a literature review is completed in relation to PEM fuel cell water flooding. It is clear that droplet formation, movement and interaction with the Gas Diffusion Layer (GDL) have been studied extensively. However slug formation and droplet accumulation in the flow channels has not been analysed in detail. In this study, a Computational Fluid Dynamic (CFD) model and Volume of Fluid (VOF) method is used to simulate water droplet movement and slug formation in PEM fuel cell mini-channels. In addition, water slug visualisation is recorded in ex situ PEM fuel cell mini-channels. Observation and simulation results are discussed with relation to slug formation and the implications to PEM fuel cell performance
Modelling impact of morphological urban structure and cognitive behaviour on pedestrian flows.

A novel, discrete space-time model of pedestrian behaviour in real urban networks is presented. An agent-based approach is used to define characteristics of individual pedestrians, based on spatial awareness and cognition theories, combined with preferential choices of different social groups. Behaviour patterns are considered incorporating rules of movement along pedestrian routes and for intermediate decision and conflict points. The model utilises dynamic volunteered geographic information system data allowing analysis of arbitrary city networks and comparison of the effect of grid structure and amenity distribution. As an example, two distinctive social groups are considered, namely 'directed' and 'leisure', and their interaction, together with the way in which flow congestion and changes in network morphology affect route choice in central London areas. The resulting stress and flow characteristics of the urban network simulations as well as the impact on individual agent paths and travel times, are discussed. © 2014 Springer International Publishing