pinecone/core-2020-05-10-deduplication huggingface dataset:
Student and community perceptions about organ donors, non-donors, and transplant recipients

Despite efforts to encourage organ donation, low organ donation rates in Australia and other Western nations do not meet the demand for transplantable organs. One influence on organ donation decision-making yet to be fully explored is that of prototype perceptions about organ donors, non-donors, and transplant recipients. We conducted focus groups and interviews with 54 student and community participants to explore these perceptions of donors and non-donors in a living and posthumous context, as well as transplant recipients. Using content and thematic analysis, transcripts were analysed for consistently emerging themes. Donors were generally perceived positively as altruistic and giving and as ordinary people; however, some participants questioned the motives of living anonymous donors. Non-donors were commonly viewed negatively as self-absorbed and unaware, with living-related non-donors particularly perceived as cold-hearted and weak. Transplant recipients were generally viewed sympathetically (unfortunate and unwell); however, many participants also expressed negative views about transplant recipients as responsible for their predicament, depending upon the type of organ transplant needed. To encourage people's willingness to donate their organs, it is crucial to understand the extent to which these perceptions influence organ donation decisions
Added Value-based Approach to Analyze Electronic Commerce and Mobile Commerce Business Models

In this contribution we propose to apply the theory of informational added values (IAV) on
electronic commerce (EC) and mobile commerce (MC). We state that for the success of electronic and mobile offers it is not sufficient to merely make a conventional offer available with new media. Instead, the use of electronic and mobile communication technology is only remunerative if it results in obtaining distinct supplementary IAV. This depends on the exploitation of certain faculties of the used technology. For EC, we call these the four electronic added values (EAV): reduction of temporal and certain spatial limitations, reduction of technical limitations, multi-mediality of access and egalitarian access. For MC, we call these the four mobile added values (MAV): ubiquity, contextsensitivity,identifying functions and command and control functions. We can find EAV and MAV as typical properties of EC or MC applications. EAV are the basis for the superiority of Internet applications compared with offline solutions. The relationship between the separate EAV and IAV will be explained and analyzed. Proceeding analogously for mobile applications, we analyze the relationship between MAV and resulting IAV. The outcome is an extension of the theory of informational added values with the concept of electronic and mobile added values. This allows for an application of the theory to both EC and MC in order to analyze and qualitatively evaluate any given business model. For determining its crucial added value we have to identify the EAV/MAV which are capitalized and can deduce the IAV resulting for each party involved. The concept put forward is a suggestion to approach business models, with the focus on typical evaluation criteria for Internet/mobile business models. It is also suitable to compare different business models and to put their added value for the involved parties in a context. In this way, objective criteria are established reducing subjectivity and allowing to make certain predictions. The paper ends with a critical review and the perspective for further research.
Performance and trade-offs in microfinance organizations - does ownership matter?

Policy advocates argue the case for the transformation of non-government Microfinance Organizations (MFOs) into shareholder owned firms. The argument is that this will bring about superior performance. This paper investigates whether the superiority of shareholder owned MFOs is empirically supported. The findings indicate that the difference between shareholder owned MFOs and non-government MFOs is minimal. Our results contradict established paradigms and policy guidelines in the industry. However, the results are not necessarily surprising since ownership theories do not predict a clear preference for one type of ownership in the microfinance market. Furthermore, findings in general banking markets as well as the pro-poor banking history indicate that mutual and non-profit ownership can compete successfully with investor ownership.
On the Duration of Technology Licensing

We model an innovator's choice of payment scheme and duration as a joint decision in a multi-period licensing game with potential sequential innovations and some irreversibility of technology transfer. We find that it may be optimal to license the innovation for less than the full length of the patent and that royalty contracts can be more profitable than fixed-fee licensing even in the absence of information asymmetry and risk aversion. Moreover, licensing contracts based on royalty have a longer duration than fixed-fee licenses and are more likely to be used in industries where sequential innovations are frequent and intellectual property protection is weak. Our paper also highlights an important link between the study of technology licensing and the theory of durable goods.
Dependence Estimation and Visualization in Multivariate Extremes with Applications to Financial Data

We investigate extreme dependence in a multivariate setting with special emphasis on financial applications. We introduce a new dependence function which allows us to capture the complete extreme dependence structure and present a nonparametric estimation procedure. The new dependence function is compared with existing measures including the spectral measure and other devices measuring extreme dependence. We also apply our method to a financial data set of zero coupon swap rates and estimate the extreme dependence in the data.
Externalities, Communication and the Allocation of Decision Rights

This paper views authority as the right to undertake decisions that impose externalities on other members of the organization. When only decision rights can be contractually assigned to one of the organization’s stakeholders, the optimal assignment minimizes the resulting inefficiencies by giving control rights to the party with the highest stake in the organization’s decisions. Under asymmetric information, the efficient allocation of authority depends on the communication of private information. In the case of multiple decision areas, divided control rights may enhance organizational efficiency unless there exist complementarities between different decisions.
Measurements of long-range azimuthal anisotropies and associated Fourier coefficients for pp collisions at √s=5.02 and 13 TeV and p+Pb collisions at √sNN=5.02 TeV with the ATLAS detector

ATLAS measurements of two-particle correlations are presented for √s=5.02 and 13 TeV ppcollisions and for √sNN=5.02 TeV p+Pb  collisions at the LHC. The correlation functions are measured as a function of relative azimuthal angle Δϕ, and pseudorapidity separation Δη, using charged particles detected within the pseudorapidity interval |η|<2.5. Azimuthal modulation in the long-range component of the correlation function, with |Δη|>2, is studied using a template fitting procedure to remove a “back-to-back” contribution to the correlation function that primarily arises from hard-scattering processes. In addition to the elliptic, cos (2Δϕ), modulation observed in a previous measurement, the pp correlation functions exhibit significant cos (3Δϕ) and cos (4Δϕ) modulation. The Fourier coefficients vn, n associated with the cos (nΔϕ)  modulation of the correlation functions for n=2–4 are measured as a function of charged-particle multiplicity and charged-particle transverse momentum. The Fourier coefficients are observed to be compatible with cos (nϕ)  modulation of per-event single-particle azimuthal angle distributions. The single-particle Fourier coefficients vn are measured as a function of charged-particle multiplicity, and charged-particle transverse momentum for n=2–4. The integrated luminosities used in this analysis are, 64nb−1  for the √s=13 TeV pp data, 170 nb−1  for the √ s = 5.02  TeV pp data, and 28 nb−1 for the √sNN = 5.02  TeV p+Pb data
Is aristolochic acid nephropathy a widespread problem in developing countries? A case study of Aristolochia indica L. in Bangladesh using an ethnobotanical - phytochemical approach

Ethnopharmacological relevance: Species of Aristolochia are associated with aristolochic acid nephropathy (AAN), a renal interstitial fibrosis and upper urinary tract cancer (UUC). Aristolochic acid nephropathy has been reported in ten countries but its true incidence is unknown and most likely underestimated. By combining an ethnobotanical and phytochemical approach we provide evidence for the risk of AAN occurring in Bangladesh. More specifically, we assess the intra-specific variation of aristolochic acid analogues in medicinally used A. indica samples from Bangladesh.\ud
\ud
Materials and Methods: Ethnobotanical information was collected from 16 kavirajes (traditional healers) in different study locations in Bangladesh. Plant samples were obtained from native habitats, botanical gardens, herbal markets and pharmaceutical companies. The samples were extracted using 70% methanol and were analysed using LC-DAD-MS and 1H-NMR.\ud
\ud
Results: Roots as well as leaves are commonly used for symptoms such as snake bites and sexual problems. Among the informants knowledge about toxicity or side effects is very limited and A. indica is often administered in very high doses. Replacement of A. indica with other medicinal plants such as Rauvolfia serpentina (L.) Benth. ex Kurz was common. A. indica samples contained a variety of aristolochic acid analogues such as aristolochic acid I, aristolochic acid II, cepharadione A and related compounds.\ud
\ud
Conclusions: AAN cases are likely to occur in Bangladesh and more awareness needs to be raised about the health risks associated with the use of A. indica and other species of Aristolochia as herbal medicines
Access of energetic particles to Titan's exobase: a study of Cassini's T9 flyby

We study how the local electromagnetic disturbances introduced by Titan affect the ionization rates of the atmosphere. For this, we model the precipitation of energetic particles, specifically hydrogen and oxygen ions with energies between 1 keV and 1 MeV, into Titan's exobase for the specific magnetospheric configuration of the T9 flyby. For the study, a particle tracing software package is used which consists of an integration of the single particle Lorentz force equation using a 4th order Runge-Kutta numerical method. For the electromagnetic disturbances, the output of the A.I.K.E.F. hybrid code (kinetic ions, fluid electrons) is used, allowing the possibility of analyzing the disturbances and asymmetries in the access of energetic particles originated by their large gyroradii. By combining these methods, 2D maps showing the access of each set of particles were produced. We show that the access of different particles is largely dominated by their gyroradii, with the complexity of the maps increasing with decreasing gyroradius, due to the larger effect that local disturbances introduced by the presence of the moon have in the trajectory of the particles with lower energies. We also show that for particles with gyroradii much larger than the moon's radius, simpler descriptions of the electromagnetic environment can reproduce similar results to those obtained when using the full hybrid simulation description, with simple north-south fields being sufficient to reproduce the hybrid code results for O+  ions with energies larger than 10 keV but not enough to reproduce those for H+H+ ions at any of the energies covered in the present study. Finally, by combining the maps created with upstream plasma flow measurements by the MIMI/CHEMS instrument, we are able to estimate normalized fluxes arriving at different selected positions of the moon's exobase. We then use these fluxes to calculate energy deposition and non-dissociative N2 ionization rates for precipitating O+O+ and H+H+ ions and find differences in the ion production rates of up to almost 80% at the selected positions. All these results combined show that the electromagnetic field disturbances present in the vicinity of Titan significantly affect the contribution of energetic ions to local ionization profiles
Basil as functional and preserving ingredient in "serra da Estrela" cheese

All rights reserved. Antitumor, antimicrobial and antioxidant activities of basil were studied, along with its characterization in phenolic compounds, organic acids and soluble sugars. The results placed basil as a valuable candidate for functionalization and conservation of food products, maintaining their nutritional properties, while increasing their shelf life and potential health effects. The basil leaves were then incorporated in "Serra da Estrela Cheese", either in its dehydrated form or as a decoction. The cheeses were then subject to a nutritional evaluation, being characterized for their fatty acids, minerals and CIE color parameters. To assess the combined effects of plant incorporation and storage time, a 2-way ANOVA was used to process the results, further analysed through a linear discriminant analysis. Overall, basil leaves provided antioxidant activity to the cheeses, reduced the moisture, and preserved the unsaturated fatty acids and proteins. Comparing both incorporation types, the decoctions had a higher functionalizing and conservative effect.The authors are grateful to Queijos Casa Matias, Lda and Cantinho
das Aromáticas, Lda. for providing the cheese and basil samples,
respectively. The authors also acknowledge the Portuguese
PRODER project No. 46577-PlantLact, the Foundation for Science
and Technology (FCT, Portugal) for financial support to the CIMO
research centre (Pest-OE/AGR/UI0690/2014) and ALIMNOVA
research group (UCM-GR35/10A). L. Barros, J.C.M. Barreira and R.
C. Calhelha acknowledge the FCT for their post-doctoral grants
(SFRH/BPD/107855/2015, SFRH/BPD/72802/2010 and SFRH/
BPD/68344/2010). The Serbian Ministry of Education is also
acknowledged for the Science and Technological Development
Grant No. 173032.info:eu-repo/semantics/publishedVersio
SCOTROC 2A: Carboplatin followed by docetaxel or docetaxel gemcitabine as first-line chemotherapy for ovarian cancer

SCOTROC 2A: Carboplatin followed by docetaxel or docetaxel gemcitabine as first-line chemotherapy for ovarian cancer The feasibility of sequential carboplatin followed by docetaxel-based therapy for untreated ovarian cancer was determined. Patients received four q3w cycles of carboplatin AUC 7, then four q3w cycles of either docetaxel 100 mg m(-2) (day 1) (arm A); docetaxel 75 mg m(-2) (day 8) and gemcitabine 1250 mg m(-2) (days 1,8) (arm B) or docetaxel 25 mg m(-2) and gemcitabine 800 mg m(-2) (both given weekly (days 1,8,15)) (arm C). A total of 44 patients were randomised to each treatment arm. None of the arms demonstrated an eight cycle completion rate (70.5/72.7/45.5% in arms A/B/C, respectively), which was statistically greater than 60% (P = 0.102, P = 0.056, P = 0.982) which was our formal feasibility criteria, although only the completion rate in arm C was clearly worse than this level. The overall response rate (ORR) after carboplatin was 65.7% in 70 evaluable patients. In evaluable patients, ORRs after docetaxel-based cycles were: arm A 84.0% (21 out of 25); arm B 77.3% (17 out of 22); arm C 69.6% (16 out of 23). At follow-up (median 30 months), median progression-free survival times were: arm A 15.5 months (95% Cl: 10.5 - 20.6); arm B 18.1 months (95% Cl: 15.9 - 20.3); arm C, 13.7 months (95% Cl: 12.8 - 14.6). Neutropenia was the predominant grade 3 - 4 haematological toxicity: 77.8/85.7/54.4% in arms A/B/C, respectively. Dyspnoea was markedly increased in both gemcitabine-containing arms (P = 0.001) but was worse in arm C. Although just failing to rule out eight cycle completion rates less than 60%, within the statistical limitations of these small cohorts, the overall results for arms A and B are encouraging. Larger phase III studies are required to test these combinations
Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10

BACKGROUND: The human epidermal growth factor receptor (EGFR) is an important therapeutic target in oncology, and three different types of EGFR inhibitors have been approved for the treatment of cancer patients. However, there has been no clear association between the expression levels of EGFR protein in the tumours determined by the FDA-approved EGFR PharmDx kit (Dako) or other standard anti-EGFR antibodies and the response to the EGFR inhibitors. METHOD: In this study, we investigated the potential of our anti-EGFR monoclonal antibodies (mAbs; ICR9, ICR10, ICR16) for immunohistochemical diagnosis of wild-type EGFR and/or the type-III deletion mutant form of EGFR (EGFRvIII) in formalin-fixed, paraffin-embedded human tumour specimens. RESULTS: We found that the anti-EGFR mAb in the EGFR PharmDx kit stained both wild-type and EGFRvIII-expressing cells in formalin-fixed, paraffin-embedded sections. This pattern of EGFR immunostaining was also found with our anti-EGFR mAb ICR16. In contrast, mAbs ICR10 and ICR9 were specific for the wild-type EGFR. CONCLUSION: We conclude that mAbs ICR9 and ICR10 are ideal tools for investigating the expression patterns of wild-type EGFR protein in tumour specimens using immunohistochemistry, and to determine their prognostic significance, as well as predictive value for response to therapy with EGFR antibodies. British Journal of Cancer (2012) 106, 883-888. doi:10.1038/bjc.2012.27 www.bjcancer.com Published online 7 February 2012 (C) 2012 Cancer Research U
Relativistic Jets in Active Galactic Nuclei and Microquasars

Collimated outflows (jets) appear to be a ubiquitous phenomenon associated with the accretion of material onto a compact object. Despite this ubiquity, many fundamental physics aspects of jets are still poorly understood and constrained. These include the mechanism of launching and accelerating jets, the connection between these processes and the nature of the accretion flow, and the role of magnetic fields; the physics responsible for the collimation of jets over tens of thousands to even millions of gravitational radii of the central accreting object; the matter content of jets; the location of the region(s) accelerating particles to TeV (possibly even PeV and EeV) energies (as evidenced by (Formula presented.)-ray emission observed from many jet sources) and the physical processes responsible for this particle acceleration; the radiative processes giving rise to the observed multi-wavelength emission; and the topology of magnetic fields and their role in the jet collimation and particle acceleration processes. This chapter reviews the main knowns and unknowns in our current understanding of relativistic jets, in the context of the main model ingredients for Galactic and extragalactic jet sources. It discusses aspects specific to active Galactic nuclei (especially blazars) and microquasars, and then presents a comparative discussion of similarities and differences between them.Fil: Romero, Gustavo Esteban. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomia; ArgentinaFil: Boettcher, Markus. North-West University; SudáfricaFil: Markoff, Sera. University of Amsterdam; Países BajosFil: Tavecchio, Fabrizio. Osservatorio Astronomico Di Brera; Itali
Search for supersymmetry in final states with missing transverse momentum and multiple b-jets in proton-proton collisions at √s=13 TeV with the ATLAS detector

A search for supersymmetry involving the pair production of gluinos decaying via third-generation squarks into the lightest neutralino (χ~01) is reported. It uses LHC proton-proton collision data at a centre-of-mass energy s√=13 TeV with an integrated luminosity of 36.1 fb−1 collected with the ATLAS detector in 2015 and 2016. The search is performed in events containing large missing transverse momentum and several energetic jets, at least three of which must be identified as originating from b-quarks. To increase the sensitivity, the sample is divided into subsamples based on the presence or absence of electrons or muons. No excess is found above the predicted background. For χ~01 masses below approximately 300 GeV, gluino masses of less than 1.97 (1.92) TeV are excluded at 95% confidence level in simplified models involving the pair production of gluinos that decay via top (bottom) squarks. An interpretation of the limits in terms of the branching ratios of the gluinos into third-generation squarks is also provided. These results improve upon the exclusion limits obtained with the 3.2 fb−1 of data collected in 2015
Performance Analysis of Two Quantum Reaction Dynamics Codes: Time-Dependent and Time-Independent Strategies

The computer simulation of reaction dynamics has nowadays reached a remarkable degree of accuracy. Triatomic elementary reactions are rigorously studied with great detail on a straightforward basis using a considerable variety of Quantum Dynamics computational tools available to the scientific community. In our contribution we compare the performance of two quantum scattering codes in the computation of reaction cross sections of a triatomic benchmark reaction such as the gas phase reaction Ne + H2+ %12. NeH<sup>+</sup>+ H. The computational codes are selected as representative of time-dependent (Real Wave Packet [ ]) and time-independent (ABC [ ]) methodologies. The main conclusion to be drawn from our study is that both strategies are, to a great extent, not competing but rather complementary. While time-dependent calculations advantages with respect to the energy range that can be covered in a single simulation, time-independent approaches offer much more detailed information from each single energy calculation. Further details such as the calculation of reactivity at very low collision energies or the computational effort related to account for the Coriolis couplings are analyzed in this paper
Measurement of the triple-differential cross section for photon+jets production in proton-proton collisions at sqrt(s)=7 TeV

A measurement of the triple-differential cross section (sigma as a function of the photon pt and eta and the jet eta) in photon+jets final states using a data sample from proton-proton collisions at sqrt(s)=7 TeV is presented. This sample corresponds to an integrated luminosity of 2.14 inverse femtobarns collected by the CMS detector at the LHC. Photons and jets are reconstructed within a pseudorapidity range of abs(eta) < 2.5, and are required to have transverse momenta in the range 40 < pt(gamma) < 300 GeV and pt(jet) > 30 GeV, respectively. The measurements are compared to theoretical predictions from the SHERPA leading-order QCD Monte Carlo event generator and the next-to-leading-order perturbative QCD calculation from JETPHOX. The predictions are found to be consistent with the data over most of the examined kinematic region