pinecone/core-2020-05-10-deduplication huggingface dataset:
A submillimetre search for pre-and proto-brown dwarfs in Chamaeleon II

Astronomy and Astrophysics 590. (2016): A79 reproduced with permission from Astronomy & AstrophysicsThe Chamaeleon II molecular cloud is an active star-forming region that offers an excellent opportunity to study the formation of brown dwarfs in the southern hemisphere. Aims. Our aims are to identify a population of pre-and proto-brown dwarfs (5σ mass limit threshold of ~0.015 M⊙) and provide information on the formation mechanisms of substellar objects. Methods. We performed high sensitivity observations at 870 μm using the LABOCA bolometer at the APEX telescope towards an active star-forming region in Chamaeleon II. The data are complemented by an extensive multiwavelength catalogue of sources, which covers the optical to the far-infrared, to study the nature of the LABOCA detections. Results. We detect 15 cores at 870 μm, and 11 of them show masses in the substellar regime. The most intense objects in the surveyed field correspond to the submillimetre counterparts of the well-known young stellar objects DK Cha and IRAS 12500-7658. We identify a possible proto-brown dwarf candidate (ChaII-APEX-L) with IRAC emission at 3.6 and 4.5 μm. Conclusions. Our analysis indicates that most of the spatially resolved cores are transient, and that the point-like starless cores in the substellar regime (with masses between 0.016 M⊙ and 0.066 M⊙) could be pre-brown dwarfs cores that are gravitationally unstable if they have radii less than 220 AU to 907 AU (1.2′′ to 5′′ at 178 pc), respectively, for different masses. ALMA observations will be key to revealing the energetic state of these pre-brown dwarfs candidatesI.d.G. acknowledge support from MICINN (Spain) AYA2011-30228-C03 grant (including FEDER funds). H.B. is funded by the Ramón y Cajal fellowship program number RYC-2009-04497. A.B. acknowledges financial support from the Proyecto Fondecyt Iniciación 11140572. A.P. acknowledges the financial support from UNAM, and CONACyT (México). C.E. is partly supported by Spanish Grants AYA 2011-26202 and AYA 2014- 55840-P.This research has been funded by Spanish grants AYA 2012-38897-C02-01 and PRICIT-S2009/ESP-149
Logarithmic corrected F(R) gravity in the light of Planck 2015

AbstractIn this Letter, we consider the theory of F(R) gravity with the Lagrangian density £=R+αR2+βR2ln⁡βR. We obtain the constant curvature solutions and find the scalar potential of the gravitational field. We also obtain the mass squared of a scalaron in the Einstein's frame. We find cosmological parameters corresponding to the recent Plank 2015 results. Finally, we analyze the critical points and stability of the new modified theory of gravity and find that logarithmic correction is necessary to have successful model
Simulating spin dynamics in organic solids under heteronuclear decoupling

AbstractAlthough considerable progress has been made in simulating the dynamics of multiple coupled nuclear spins, predicting the evolution of nuclear magnetisation in the presence of radio-frequency decoupling remains challenging. We use exact numerical simulations of the spin dynamics under simultaneous magic-angle spinning and RF decoupling to determine the extent to which numerical simulations can be used to predict the experimental performance of heteronuclear decoupling for the CW, TPPM and XiX sequences, using the methylene group of glycine as a model system. The signal decay times are shown to be strongly dependent on the largest spin order simulated. Unexpectedly large differences are observed between the dynamics with and without spin echoes. Qualitative trends are well reproduced by modestly sized spin system simulations, and the effects of finite spin-system size can, in favourable cases, be mitigated by extrapolation. Quantitative prediction of the behaviour in complex parameter spaces is found, however, to be very challenging, suggesting that there are significant limits to the role of numerical simulations in RF decoupling problems, even when specialist techniques, such as state-space restriction, are used
A computational method for the coupled solution of reaction–diffusion equations on evolving domains and manifolds: Application to a model of cell migration and chemotaxis

AbstractIn this paper, we devise a moving mesh finite element method for the approximate solution of coupled bulk–surface reaction–diffusion equations on an evolving two dimensional domain. Fundamental to the success of the method is the robust generation of bulk and surface meshes. For this purpose, we use a novel moving mesh partial differential equation (MMPDE) approach. The developed method is applied to model problems with known analytical solutions; these experiments indicate second-order spatial and temporal accuracy. Coupled bulk–surface problems occur frequently in many areas; in particular, in the modelling of eukaryotic cell migration and chemotaxis. We apply the method to a model of the two-way interaction of a migrating cell in a chemotactic field, where the bulk region corresponds to the extracellular region and the surface to the cell membrane
The symmetric Radon–Nikodým property for tensor norms

AbstractWe introduce the symmetric Radon–Nikodým property (sRN property) for finitely generated s-tensor norms β of order n and prove a Lewis type theorem for s-tensor norms with this property. As a consequence, if β is a projective s-tensor norm with the sRN property, then for every Asplund space E, the canonical mapping ⊗˜βn,sE′→(⊗˜β′n,sE)′ is a metric surjection. This can be rephrased as the isometric isomorphism Qmin(E)=Q(E) for some polynomial ideal Q. We also relate the sRN property of an s-tensor norm with the Asplund or Radon–Nikodým properties of different tensor products. As an application, results concerning the ideal of n-homogeneous extendible polynomials are obtained, as well as a new proof of the well-known isometric isomorphism between nuclear and integral polynomials on Asplund spaces. An analogous study is carried out for full tensor products
Identification and characterization of a novel factor XIIa inhibitor in the hematophagous insect, Triatoma infestans (Hemiptera: Reduviidae)

AbstractRecently, we have cloned several Kazal-type serine protease inhibitors from the midgut of the Triatoma infestans bug. A single gene composed of multi Kazal-type domains, in tandem, encodes these inhibitors. In this work, we describe the purification and characterization of recombinant infestins 3-4 and 4, which are potent factor XIIa inhibitors (Ki=67 pM and 128 pM, respectively). We also identified the first native factor XIIa inhibitor from a hematophagous insect. The factor XIIa inhibitory activity of infestin 4 demonstrates extremely efficient anticoagulant activity, prolonging activated partial thromboplastin time by approximately 3 times. Our results suggest that infestins perform a very important role in the T. infestans midgut during meal acquisition and digestion by controlling blood coagulation by means of inhibiting thrombin and factor XIIa
Isolation of flow and nonflow correlations by two- and four-particle cumulant measurements of azimuthal harmonics in sNN=200 GeV Au+Au collisions

AbstractA data-driven method was applied to Au+Au collisions at sNN=200 GeV made with the STAR detector at RHIC to isolate pseudorapidity distance Δη-dependent and Δη-independent correlations by using two- and four-particle azimuthal cumulant measurements. We identified a Δη-independent component of the correlation, which is dominated by anisotropic flow and flow fluctuations. It was also found to be independent of η within the measured range of pseudorapidity |η|<1. In 20–30% central Au+Au collisions, the relative flow fluctuation was found to be 34%±2%(stat.)±3%(sys.) for particles with transverse momentum pT less than 2 GeV/c. The Δη-dependent part, attributed to nonflow correlations, is found to be 5%±2%(sys.) relative to the flow of the measured second harmonic cumulant at |Δη|>0.7
Damage analysis of pseudo-ductile thin-ply UD hybrid composites – A new analytical method

AbstractA new simple analytical approach for predicting all possible damage modes of Uni-Directional (UD) hybrid composites and their stress–strain response in tensile loading is proposed. To do so, the required stress level for the damage modes (fragmentation, delamination and final failure) are assessed separately. The damage process of the UD hybrid can then be predicted based on the order of the required stress for each damage mode. Using the developed analytical method, a new series of standard-thickness glass/thin-ply carbon hybrid composites was tested and a very good pseudo-ductile tensile response with 1.0% pseudo-ductile strain and no load drop until final failure was achieved. The yield stress value for the best tested layup was more than 1130MPa. The proposed analytical method is simple, very fast to run and it gives accurate results that can be used for designing thin-ply UD hybrid laminates with the desired tensile response and for conducting further parametric studies
An experiment of X-ray photon–photon elastic scattering with a Laue-case beam collider

AbstractWe report a search for photon–photon elastic scattering in vacuum in the X-ray region at an energy in the center of mass system of ωcms=6.5keV for which the QED cross section is σQED=2.5×10−47m2. An X-ray beam provided by the SACLA X-ray Free Electron Laser is split and the two beamlets are made to collide at right angle, with a total integrated luminosity of (1.24±0.08)×1028m−2. No signal X rays from the elastic scattering that satisfy the correlation between energy and scattering angle were detected. We obtain a 95% C.L. upper limit for the scattering cross section of 1.9×10−27m2 at ωcms=6.5keV. The upper limit is the lowest upper limit obtained so far by keV experiments
In the pursuit of a semantic similarity metric based on UMLS annotations for articles in PubMed Central Open Access

AbstractMotivationAlthough full-text articles are provided by the publishers in electronic formats, it remains a challenge to find related work beyond the title and abstract context. Identifying related articles based on their abstract is indeed a good starting point; this process is straightforward and does not consume as many resources as full-text based similarity would require. However, further analyses may require in-depth understanding of the full content. Two articles with highly related abstracts can be substantially different regarding the full content. How similarity differs when considering title-and-abstract versus full-text and which semantic similarity metric provides better results when dealing with full-text articles are the main issues addressed in this manuscript.MethodsWe have benchmarked three similarity metrics – BM25, PMRA, and Cosine, in order to determine which one performs best when using concept-based annotations on full-text documents. We also evaluated variations in similarity values based on title-and-abstract against those relying on full-text. Our test dataset comprises the Genomics track article collection from the 2005 Text Retrieval Conference. Initially, we used an entity recognition software to semantically annotate titles and abstracts as well as full-text with concepts defined in the Unified Medical Language System (UMLS®). For each article, we created a document profile, i.e., a set of identified concepts, term frequency, and inverse document frequency; we then applied various similarity metrics to those document profiles. We considered correlation, precision, recall, and F1 in order to determine which similarity metric performs best with concept-based annotations. For those full-text articles available in PubMed Central Open Access (PMC-OA), we also performed dispersion analyses in order to understand how similarity varies when considering full-text articles.ResultsWe have found that the PubMed Related Articles similarity metric is the most suitable for full-text articles annotated with UMLS concepts. For similarity values above 0.8, all metrics exhibited an F1 around 0.2 and a recall around 0.1; BM25 showed the highest precision close to 1; in all cases the concept-based metrics performed better than the word-stem-based one. Our experiments show that similarity values vary when considering only title-and-abstract versus full-text similarity. Therefore, analyses based on full-text become useful when a given research requires going beyond title and abstract, particularly regarding connectivity across articles.AvailabilityVisualization available at ljgarcia.github.io/semsim.benchmark/, data available at http://dx.doi.org/10.5281/zenodo.13323
Transverse momentum spectra of charged particles in proton–proton collisions at s=900 GeV with ALICE at the LHC

AbstractThe inclusive charged particle transverse momentum distribution is measured in proton–proton collisions at s=900 GeV at the LHC using the ALICE detector. The measurement is performed in the central pseudorapidity region (|η|<0.8) over the transverse momentum range 0.15<pT<10 GeV/c. The correlation between transverse momentum and particle multiplicity is also studied. Results are presented for inelastic (INEL) and non-single-diffractive (NSD) events. The average transverse momentum for |η|<0.8 is 〈pT〉INEL=0.483±0.001 (stat.)±0.007 (syst.) GeV/c and 〈pT〉NSD=0.489±0.001 (stat.)±0.007 (syst.) GeV/c, respectively. The data exhibit a slightly larger 〈pT〉 than measurements in wider pseudorapidity intervals. The results are compared to simulations with the Monte Carlo event generators PYTHIA and PHOJET
A computational tool to predict the evolutionarily conserved protein–protein interaction hot-spot residues from the structure of the unbound protein

AbstractIdentifying hot-spot residues – residues that are critical to protein–protein binding – can help to elucidate a protein’s function and assist in designing therapeutic molecules to target those residues. We present a novel computational tool, termed spatial-interaction-map (SIM), to predict the hot-spot residues of an evolutionarily conserved protein–protein interaction from the structure of an unbound protein alone. SIM can predict the protein hot-spot residues with an accuracy of 36–57%. Thus, the SIM tool can be used to predict the yet unknown hot-spot residues for many proteins for which the structure of the protein–protein complexes are not available, thereby providing a clue to their functions and an opportunity to design therapeutic molecules to target these proteins
Noncommutative SU(N) theories, the axial anomaly, Fujikawa's method and the Atiyah–Singer index

AbstractFujikawa's method is employed to compute at first order in the noncommutative parameter the U(1)A anomaly for noncommutative SU(N). We consider the most general Seiberg–Witten map which commutes with hermiticity and complex conjugation and a noncommutative matrix parameter, θμν, which is of “magnetic” type. Our results for SU(N) can be readily generalized to cover the case of general nonsemisimple gauge groups when the symmetric Seiberg–Witten map is used. Connection with the Atiyah–Singer index theorem is also made
Conjugate observations of Saturn’s northern and southern H3+ aurorae

AbstractWe present an analysis of recent high spatial and spectral resolution ground-based infrared observations of H3+ obtained with the 10-m Keck II telescope in April 2011. We observed H3+ emission from Saturn’s northern and southern auroral regions, simultaneously, over the course of more than 2h, obtaining spectral images along the central meridian as Saturn rotated. Previous ground-based work has derived only an average temperature of an individual polar region, summing an entire night of observations. Here we analyse 20 H3+ spectra, 10 for each hemisphere, providing H3+ temperature, column density and total emission in both the northern and southern polar regions simultaneously, improving on past results in temporal cadence and simultaneity. We find that: (1) the average thermospheric temperatures are 527±18K in northern Spring and 583±13K in southern Autumn, respectively; (2) this asymmetry in temperature is likely to be the result of an inversely proportional relationship between the total thermospheric heating rate (Joule heating and ion drag) and magnetic field strength – i.e. the larger northern field strength leads to reduced total heating rate and a reduced temperature, irrespective of season, and (3) this implies that thermospheric heating and temperatures are relatively insensitive to seasonal effects
Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study

BackgroundActivated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in PIK3CD, the gene encoding the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ).ObjectiveWe sought to review the clinical, immunologic, histopathologic, and radiologic features of APDS in a large genetically defined international cohort.MethodsWe applied a clinical questionnaire and performed review of medical notes, radiology, histopathology, and laboratory investigations of 53 patients with APDS.ResultsRecurrent sinopulmonary infections (98%) and nonneoplastic lymphoproliferation (75%) were common, often from childhood. Other significant complications included herpesvirus infections (49%), autoinflammatory disease (34%), and lymphoma (13%). Unexpectedly, neurodevelopmental delay occurred in 19% of the cohort, suggesting a role for PI3Kδ in the central nervous system; consistent with this, PI3Kδ is broadly expressed in the developing murine central nervous system. Thoracic imaging revealed high rates of mosaic attenuation (90%) and bronchiectasis (60%). Increased IgM levels (78%), IgG deficiency (43%), and CD4 lymphopenia (84%) were significant immunologic features. No immunologic marker reliably predicted clinical severity, which ranged from asymptomatic to death in early childhood. The majority of patients received immunoglobulin replacement and antibiotic prophylaxis, and 5 patients underwent hematopoietic stem cell transplantation. Five patients died from complications of APDS.ConclusionAPDS is a combined immunodeficiency with multiple clinical manifestations, many with incomplete penetrance and others with variable expressivity. The severity of complications in some patients supports consideration of hematopoietic stem cell transplantation for severe childhood disease. Clinical trials of selective PI3Kδ inhibitors offer new prospects for APDS treatment
Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

SummaryIntegrin trafficking is key to cell migration, but little is known about the spatiotemporal organization of integrin endocytosis. Here, we show that α5β1 integrin undergoes tensin-dependent centripetal movement from the cell periphery to populate adhesions located under the nucleus. From here, ligand-engaged α5β1 integrins are internalized under control of the Arf subfamily GTPase, Arf4, and are trafficked to nearby late endosomes/lysosomes. Suppression of centripetal movement or Arf4-dependent endocytosis disrupts flow of ligand-bound integrins to late endosomes/lysosomes and their degradation within this compartment. Arf4-dependent integrin internalization is required for proper lysosome positioning and for recruitment and activation of mTOR at this cellular subcompartment. Furthermore, nutrient depletion promotes subnuclear accumulation and endocytosis of ligand-engaged α5β1 integrins via inhibition of mTORC1. This two-way regulatory interaction between mTORC1 and integrin trafficking in combination with data describing a role for tensin in invasive cell migration indicate interesting links between nutrient signaling and metastasis
Renormalization group approach to a p-wave superconducting model

AbstractWe present in this work an exact renormalization group (RG) treatment of a one-dimensional p-wave superconductor. The model proposed by Kitaev consists of a chain of spinless fermions with a p-wave gap. It is a paradigmatic model of great actual interest since it presents a weak pairing superconducting phase that has Majorana fermions at the ends of the chain. Those are predicted to be useful for quantum computation. The RG allows to obtain the phase diagram of the model and to study the quantum phase transition from the weak to the strong pairing phase. It yields the attractors of these phases and the critical exponents of the weak to strong pairing transition. We show that the weak pairing phase of the model is governed by a chaotic attractor being non-trivial from both its topological and RG properties. In the strong pairing phase the RG flow is towards a conventional strong coupling fixed point. Finally, we propose an alternative way for obtaining p-wave superconductivity in a one-dimensional system without spin–orbit interaction
Constants of Weitzenböck derivations and invariants of unipotent transformations acting on relatively free algebras

AbstractIn commutative algebra, a Weitzenböck derivation is a nonzero triangular linear derivation of the polynomial algebra K[x1,…,xm] in several variables over a field K of characteristic 0. The classical theorem of Weitzenböck states that the algebra of constants is finitely generated. (This algebra coincides with the algebra of invariants of a single unipotent transformation.) In this paper we study the problem of finite generation of the algebras of constants of triangular linear derivations of finitely generated (not necessarily commutative or associative) algebras over K assuming that the algebras are free in some sense (in most of the cases relatively free algebras in varieties of associative or Lie algebras). In this case the algebra of constants also coincides with the algebra of invariants of some unipotent transformation.The main results are the following: (1) We show that the subalgebra of constants of a factor algebra can be lifted to the subalgebra of constants. (2) For all varieties of associative algebras which are not nilpotent in Lie sense the subalgebras of constants of the relatively free algebras of rank ⩾2 are not finitely generated. (3) We describe the generators of the subalgebra of constants for all factor algebras K〈x,y〉/I modulo a GL2(K)-invariant ideal I. (4) Applying known results from commutative algebra, we construct classes of automorphisms of the algebra generated by two generic 2×2 matrices. We obtain also some partial results on relatively free Lie algebras
Conformal invariant powers of the Laplacian, Fefferman–Graham ambient metric and Ricci gauging

AbstractThe hierarchy of conformally invariant kth powers of the Laplacian acting on a scalar field with scaling dimensions Δ(k)=k−d/2, k=1,2,3, as obtained in the recent work [R. Manvelyan, D.H. Tchrakian, Phys. Lett. B 644 (2007) 370, hep-th/0611077] is rederived using the Fefferman–Graham (d+2)-dimensional ambient space approach. The corresponding mysterious “holographic” structure of these operators is clarified. We explore also the (d+2)-dimensional ambient space origin of the Ricci gauging procedure proposed by A. Iorio, L. O'Raifeartaigh, I. Sachs and C. Wiesendanger as another method of constructing the Weyl invariant Lagrangians. The corresponding gauged ambient metric, Fefferman–Graham expansion and extended Penrose–Brown–Henneaux transformations are proposed and analyzed