pinecone/core-2020-05-10-deduplication huggingface dataset:
Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the randomized multicenter BONAMI trial.

International audienceAIMS: Intracoronary administration of autologous bone marrow cells (BMCs) leads to a modest improvement in cardiac function, but the effect on myocardial viability is unknown. The aim of this randomized multicentre study was to evaluate the effect of BMC therapy on myocardial viability in patients with decreased left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI) and to identify predictive factors for improvement of myocardial viability. METHODS AND RESULTS: One hundred and one patients with AMI and successful reperfusion, LVEF ≤45%, and decreased myocardial viability (resting Tl201-SPECT) were randomized to either a control group (n = 49) or a BMC group (n = 52). Primary endpoint was improvement of myocardial viability 3 months after AMI. Baseline mean LVEF measured by radionuclide angiography was 36.3 ± 6.9%. Bone marrow cell infusion was performed 9.3 ± 1.7 days after AMI. Myocardial viability improved in 16/47 (34%) patients in the BMC group compared with 7/43 (16%) in the control group (P = 0.06). The number of non-viable segments becoming viable was 0.8 ± 1.1 in the control group and 1.2 ± 1.5 in the BMC group (P = 0.13). Multivariate analysis including major post-AMI prognostic factors showed a significant improvement of myocardial viability in BMC vs. control group (P = 0.03). Moreover, a significant adverse role for active smoking (P = 0.04) and a positive trend for microvascular obstruction (P = 0.07) were observed. CONCLUSION: Intracoronary autologous BMC administration to patients with decreased LVEF after AMI was associated with improvement of myocardial viability in multivariate-but not in univariate-analysis. A large multicentre international trial is warranted to further document the efficacy of cardiac cell therapy and better define a group of patients that will benefit from this therapy. Clinical Trial Registration Information: URL: http://www.clinicaltrials.gov. Unique identifier NCT00200707
A Cost-Regular based Hybrid Column Generation Approach

International audienceConstraint Programming (CP) offers a rich modeling language of constraints embedding efficient algorithms to handle complex and heterogeneous combinatorial problems. To solve hard combinatorial optimization problems using CP alone or hybrid CP-ILP decomposition methods, costs also have to be taken into account within the propagation process. Optimization constraints, with their cost-based filtering algorithms, aim to apply inference based on optimality rather than feasibility. This paper introduces a new optimization constraint: cost-regular. Its filtering algorithm is based on the computation of shortest and longest paths in a layered directed graph. The support information is also used to guide the search for solutions. We believe this constraint to be particularly useful in modeling and solving Column Generation subproblems and evaluate its behaviour on complex Employee Timetabling Problems through a flexible CP-based column generation approach. Computational results on generated benchmark sets and on a complex real-world instance are given
Gold Solubility in Arc Magmas: Experimental Determination of the Effect of Sulfur at 1000°C and 0.4 GPa

International audienceTo investigate the behaviour of gold in sulfur-bearing hydrous intermediate calcalkaline melts under different redox states typical of subduction-zone settings, we have determined the solubility of Au at 0.4 GPa and 1000°C for three dacitic magmas (two adakites and one calc-alkaline composition) from the North-Luzon Arc (Philippines). The experiments were performed over an oxygen fugacity (fO2) range corresponding to reducing (~NNO-1), moderately oxidizing (~NNO+1.5) and strongly oxidizing ( NNO+3) conditions as measured by solid Ni-Pd-O sensors. They were carried out in gold containers, serving also as the source of gold, in presence of variable amounts of H2O and ~1 wt% of elemental sulfur (S). Concentrations of Au in glasses were determined by laser-ablation inductively-coupled plasma mass spectrometry (LA-ICPMS). Gold solubility in S-bearing melts is drastically enhanced compared to S-free melts, by up to two orders of magnitude. In addition, very high gold solubilities are reached under reducing conditions (< NNO-1) in Fe-poor, S-rich, sulfide-saturated melts probably as a result of an increase of fH2S, and a strong increase of gold solubility is observed at the sulfide/sulfate transition (from ~NNO+1.25 to NNO+1.6) due to the destabilization of sulfides and the increase of melt S2- concentration. Thermodynamic modelling of the experimental results suggest that the dissolution of gold in silicate melt is the result of a combination of various gold species (Au0, Au2O, Au2O3, Au2S3, Au2(SO4)3, and Au2FeS2) present in the melt in variable proportions, depending on the three parameters considered in the model - log fO2, log fS2 and log XFeS - which are the main variables controlling the dissolution of gold in melt under our experimental PTX conditions. Our modelling shows that Au2FeS2 is the main gold species dissolved under reducing conditions (i.e., S6+/Stotal ~ 0), whereas at sulfate saturation gold is mainly dissolved as Au metal and Au2O. The present study shows that sulfide undersaturation of primary mantle magmas or/and highly oxidizing conditions are not required for metal mobilization from the source, since gold enrichment in evolving arc magmas and exsolving fluid phases is likely to occur over a wide range of fO2 at sulfide saturation, from NNO < -1 to the sulfide-sulfate transition (i.e., NNO+0.5-2.0); nevertheless it is critically controlled by variations of fS2 and fH2S. The role of Au-enriched slab partial melts and slab-derived aqueous fluids, and the importance of the abundance of sulfur in the source for an early gold enrichment in the melt, are emphasized
Measurement of tritium in the free water of milk : spotting and quantifying some biases and proposing ways of improvement

International audience11 4 : CEA/HC 12 13 Corresponding author: 14 pierre.legoff@cea.fr -+333 80 23 40 00 -+333 80 23 52 09 15 16 Abstract 17 As one of the three natural isotopes of hydrogen, tritium is ubiquitous and might potentially 18 be present in any water or organic molecule that constitutes a biological matrix. Milk is one of 19 the most frequently monitored foodstuffs in the vicinity of chronic release of radionuclides, as 20 it is a very common product and also because it integrates deposition on large areas of grass at 21 a local scale. Different parameters have been studied to assess their impact on the reliability 22 of tritium measurements. The volume of the sample, the technique used to extract the water 23 and the level of dehydration modulate the results but in different ways: dispersion of results, 24 under-or overestimation of the tritium activity. The influence of sample storage and 25 preparation has also been investigated. Methodological improvements of tritium 26 measurements in the free water of milk are proposed. 27 2
Electrosynthesis and characterization of polymer films on silicon substrates for applications in micromanipulation.

International audienceAniline and p-phenylenediamine were electrochemically oxidized in aqueous solutions by potentiodynamic deposition using Cyclic Voltammetry (CV) technique Resulting polymer films electrodeposited on Si substrates were identified by infrared spectroscopy as polyaniline and poly(p-phenylenediamine) films. Cyclic voltammograms demonstrated that poly(p-phenylenediamine) films are non conductive contrary to polyaniline films which are conductive and electropolymerized through an autocatalytic mechanism. The morphological features (thickness, roughness, morphology) of the electrodeposited polymer films were determined using Profilometry, Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). Adhesion force properties of polymer films were also studied by means of force-distance curves obtained by Atomic Force Microscopy. The influence of some experimental parameters (potential scan speed, number of potential scans) was also studied. Thus, it was shown that the potential scan speed strongly influence both morphological features and force adhesion, when the influence of the number of potential scans was less important. Under optimal conditions, it was possible to obtain very adhesive polymer films that could be useful for the micromanipulation of Si objects
Real-time Optical Monitoring System for Dye Colour and Concentration

A system for real-time monitoring of a dye has been constructed which enables us to measure the concentration and fluctuations of the three base colours.  The method is based on light attenuation theory and its principle requires three different lasers having the three base colours.  The system consisted of a semiconductor laser and argon laser for light sources, a photodiode for a light detector and personal computer for data processing.  Detection sensitivity for the dye concentration was a few mg/l and the system can be applied for practical uses
The use of microelectrodes with AGNES

Absence of gradients and nernstian equilibrium stripping (AGNES) is a new electroanalytical technique designed to determine free heavy metal ion concentrations in solutions. AGNES had been applied, up to date, with conventional equipment such as the hanging mercury drop electrode (HMDE). Due to their much smaller volume, microelectrodes can reach a given preconcentration factor within a much shorter deposition time, so their use for AGNES has been evaluated in this work. For the particular case of the mercury microelectrode deposited onto an Ir disk (radius around 5 lm), AGNES has been successfully used for speciation purposes in the system Pb + PDCA (pyridinedicarboxylic acid). However, due to a relatively large capacitive current, which decays slowly, the limit of quantification for such microelectrodes has only been reduced by one half with respect to that of the HMDE
Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

PURPOSE: Acrylamide was classified as 'probably carcinogenic' to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide (HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) . In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log2) to improve normality. Median (25th-75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively. RESULTS: The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively. CONCLUSIONS: Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in non-smoking postmenopausal women from the EPIC cohort
Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum

The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper functioning of striatal neurons relies critically on metabotropic receptors. Specifically, the main adenosine and endocannabinoid receptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 receptor (CB1R), are of pivotal importance in the control of neuronal excitability. Facilitatory and inhibitory functional interactions between striatal A2AR and CB1R have been reported, and evidence supports that this cross-talk may rely, at least in part, on the formation of A2AR-CB1R heteromeric complexes. However, the specific location and properties of these heteromers have remained largely unknown. Here, by using techniques that allowed a precise visualization of the heteromers in situ in combination with sophisticated genetically-modified animal models, together with biochemical and pharmacological approaches, we provide a high resolution expression map and a detailed functional characterization of A2AR-CB1R heteromers in the dorsal striatum. Specifically, our data unveil that the A2AR-CB1R heteromer (i) is essentially absent from corticostriatal projections and striatonigral neurons, and, instead, is largely present in striatopallidal neurons, (ii) displays a striking G protein-coupled signaling profile, where co-stimulation of both receptors leads to strongly reduced downstream signaling, and (iii) undergoes an unprecedented dysfunction in Huntington’s disease, an archetypal disease that affects striatal neurons. Altogether, our findings may open a new conceptual framework to understand the role of coordinated adenosine-endocannabinoid signaling in the indirect striatal pathway, which may be relevant in motor function and neurodegenerative diseases
Reading the tea leaves: Medvedev's presidency through political rhetoric of federal and sub-national actors

In the absence of public information on the inner workings of the Russian political regime, especially during Medvedev's presidency, outside observers often have to rely on politicians' unguarded comments or subjective analysis. Instead, we turn to quantitative text analysis of political rhetoric. Treating governors as a quasi-expert panel, we argue that policy positions revealed in regional legislative addresses explain how elites perceived the distribution of power between Putin and Medvedev. We find that governors moved from a neutral position in 2009 to a clearly pro-Putin position in 2011, and that policy initiatives advocated by Medvedev all but evaporated from the rhetoric of governors in 2012
A phase I pharmacokinetic and safety study of cabazitaxel in adult cancer patients with normal and impaired renal function

Purpose: Limited data are available on cabazitaxel pharmacokinetics in patients with renal impairment. This open-label, multicenter study assessed cabazitaxel in patients with advanced solid tumors and normal or impaired renal function. 
Methods: Cohorts A (normal renal function: creatinine clearance [CrCL] >80 mL/min/1.73 m(2)), B (moderate renal impairment: CrCL 30 to <50 mL/min/1.73 m(2)) and C (severe impairment: CrCL < 30 mL/min/1.73 m(2)) received cabazitaxel 25 mg/m(2) (A, B) or 20 mg/m(2) (C, could be escalated to 25 mg/m(2)), once every 3 weeks. Pharmacokinetic parameters and cabazitaxel unbound fraction (F-U) were assessed using linear regression and mixed models. Geometric mean (GM) and GM ratios (GMRs) were determined using mean CrCL intervals (moderate and severe renal impairment: 40 and 15 mL/min/1.73 m(2)) versus a control (90 mL/min/1.73 m(2)). 
Results: Overall, 25 patients received cabazitaxel (median cycles: 3 [range 1-20]; Cohort A: 5 [2-13]; Cohort B: 3 [1-15]; and Cohort C: 5 [1-20]), of which 24 were eligible for pharmacokinetic analysis (eight in each cohort). For moderate and severe renal impairment versus normal renal function, GMR estimates were: clearance normalized to body surface area (CL/BSA) 0.95 (90% CI 0.80-1.13) and 0.89 (0.61-1.32); area under the curve normalized to dose (AUC/dose) 1.06 (0.88-1.27) and 1.14 (0.76-1.71); and FU 0.99 (0.94-1.04) and 0.97 (0.87-1.09), respectively. Estimated slopes of linear regression of log parameters versus log CrCL (renal impairment) were: CL/BSA 0.06 (-0.15 to 0.28); AUC/dose -0.07 (-0.30 to 0.16); and FU 0.02 (-0.05 to 0.08). Cabazitaxel safety profile was consistent with previous reports. 
Conclusions: Renal impairment had no clinically meaningful effect on cabazitaxel pharmacokinetics
Translation and human-computer interaction

This paper seeks to characterise translation as a form of human-computer interaction. The evolution of translator-computer interaction is explored and the challenges and benefits are enunciated. The concept of cognitive ergonomics is drawn on to argue for a more caring and inclusive approach towards the translator by developers of translation technology. A case is also made for wider acceptance by the translation community of the benefits of the technology at their disposal and for more humanistic research on the impact of technology on the translator, the translation profession and the translation process
Complex-Grid Spectral Algorithms For Inviscid Linear Instability of Boundary-Layer Flows

We present a suite of algorithms designed to obtain accurate numerical solutions of the generalised eigenvalue problem governing inviscid linear instability of boundary-layer type of flow in both the incompressible and compressible regimes on planar and axisymmetric curved geometries. The large gradient problems which occur in the governing equations at critical layers are treated by diverting the integration path into the complex plane, making use of complex mappings. The need for expansion of the basic flow profiles in truncated Taylor series is circumvented by solving the boundary-layer equations directly on the same (complex) grid used for the instability calculations. Iterative and direct solution algorithms are employed and the performance of the resulting algorithms using nonlinear radiation or homogeneous Dirichlet far-field boundary conditions is examined. The dependence of the solution on the parameters of the complex mappings is discussed. Results of incompressible and supersonic flow examples are presented; their excellent agreement with established works demonstrates the accuracy and robustness of the new methods presented. Means of improving the efficiency of the proposed spectral algorithms are suggested
On the testing of large PV arrays

This paper reports on the IES-UPM experience from 2006 to 2010 in the field of the characterization of PV arrays of commercial large PV plants installed in Spain within the framework of the profitable economic scenarios associated to feed-in tariff laws. This experience has extended to 200 MW and has provided valuable lessons to minimize uncertainty, which plays a key role in quality assurance procedures. The paper deals not only with classic I–V measurements but also with watt-metering-based procedures. Particular attention is paid to the selection of irradiance and cell temperature sensor
On the emergence of random initial conditions in fluid limits

The paper presents a phenomenon occurring in population processes that start near zero and have large carrying capacity. By the classical result of Kurtz (1970), such processes, normalized by the carrying capacity, converge on finite intervals to the solutions of ordinary differential equations, also known as the fluid limit. When the initial population is small relative to carrying capacity, this limit is trivial. Here we show that, viewed at suitably chosen times increasing to infinity, the process converges to the fluid limit, governed by the same dynamics, but with a random initial condition. This random initial condition is related to the martingale limit of an associated linear birth and death process
Experimental Parameters Identification of Fatigue Damage Model for Short Glass Fiber Reinforced Thermoplastics GFRP

In the present work, a new polycyclic fatigue damage model is formulated and applied for short glass fibre reinforced thermoplastics. The model is able to capture experimental trends observed for the considered composites. The damage growth description involves a set of 20 parameters in the case of a complete 3D –structure. In the current paper, it is considered the particular case of a displacement controlled fatigue tensile test involving 4 damage parameters. The present contribution is a first approach of parameter identification. It is considered a least squares sense based cost function and homogeneous fatigue tests performed on a short glass fibre reinforced polyamide. The identified set of parameters appears to be not depending on the adopted initial values. The model as the parameters determined by the minimisation algorithm, are validated on a fatigue test performed with a different loading condition
The ‘Coral Bulker’ Fuel Oil Spill on the North Coast of Portugal: Spatial and Temporal Biomarker Responses in  Mytilus galloprovincialis

In December 2000, the ship ‘Coral Bulker’ ran aground at the entrance of the port of Viana do Castelo (North–west coast of Portugal). A large amount of fuel oil was spilled and part of it reached the shore. To evaluate the spatial and temporal impact of this oil spill, a field study, and several laboratory toxicity tests were performed using Mytilus galloprovincialis as biological indicator of environmental contamination and the biomarkers glutathione S-transferases (GSTs) and acetylcholinesterase (AChE) as indicative criteria. Fifteen days after the oil spill, mussels collected at stations located near the ship presented higher and lower values of GSTs and AChE activity, respectively. These results, and those obtained in the laboratory toxicity tests, evidence that these biomarkers were sensitive indicators of exposure to this kind of pollution and were able to monitor a spatial impact of the oil spill of at least 10 km, confirming the higher level of contamination near the ship and a contamination gradient along the sampling stations. One year after the accident, such a contamination gradient was no longer evident. This study highlight the potential suitability of a biomarker approach for assessing spatial and temporal impacts of marine pollution accidents, such as fuel oil spills, suggesting the inclusion of these biomarkers in risk assessment studies, as cost-effective and early warning recognized tools. Major advantages and limitations of the biomarker approach used in this study are further discussed.http://dx.doi.org/10.1007/s10646-003-4422-
Software project management with ISO/IEC 29110

The recently published ISO/IEC 29110 standard Lifecycle profiles for Very Small Entities has at its core a Management and Engineering Guide [1] which are targeted at very small entities (enterprises, organizations, departments or projects) having up to 25 people [2], to assist them unlock the potential benefits of using standards which are specifically designed to address their needs. This paper discusses the role and structure of Project Management in the emerging ISO/IEC 29110 standard Software Process Lifecycles for Very Small Entities as well as its practical implication. This paper will also focus on the design and development of project management support documentation and their associated usage in early trials of ISO/IEC 29110