pinecone/core-2020-05-10-deduplication huggingface dataset:
Geometrically designed, variable know regression splines: asymptotics and inference

A new method for Computer Aided Geometric Design of least squares (LS) splines with variable knots, named GeDS, is presented. It is based on the property that the spline regression function, viewed as a parametric curve, has a control polygon and, due to the shape preserving and convex hull properties, closely follows the shape of this control polygon. The latter has vertices, whose x-coordinates are certain knot averages, known as the Greville sites and whose y-coordinates are the regression coefficients. Thus, manipulation of the position of the control polygon and hence of the spline curve may be interpreted as estimation of its knots and coefficients. These geometric ideas are implemented in the two stages of the GeDS estimation method. In stage A, a linear LS spline fit to the data is constructed, and viewed as the initial position of the control polygon of a higher order (n > 2) smooth spline curve. In stage B, the optimal set of knots of this higher order spline curve is found, so that its control polygon is as close to the initial polygon of stage A as possible and finally, the LS estimates of the regression coefficients of this curve are found. To implement stage A, an automatic adaptive knot location scheme for generating linear spline fits is developed. At each step of stage A, a knot is placed where a certain bias dominated measure is maximal. This stage is equipped with a novel stopping rule which serves as a model selector. The optimal knots defined in stage B ensure that the higher order spline curve is nearly a variation diminishing (i.e., shape preserving) spline  approximation to the linear fit of stage A. Error bounds for this approximation are derived in Kaishev et al. (2006). The GeDS method produces simultaneously linear, quadratic, cubic (and possibly higher order) spline fits with one and the same number of B-spline regression functions.\ud
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Large sample properties of the GeDS estimator are also explored, and asymptotic normality is established. Asymptotic conditions on the rate of growth of the knots with the increase of the sample size, which ensure that the bias is of negligible magnitude compared to the variance of the GeD estimator, are given. Based on these results, pointwise asymptotic confidence intervals with GeDS are also constructed and shown to converge to the nominal coverage probability level for a reasonable number of knots and sample sizes
Cost-effectiveness of bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitor in the treatment of non-ST-segment elevation acute coronary syndromes

OBJECTIVES: This study sought to assess the cost-effectiveness of bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitor (GPI) in thienopyridine-treated non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients undergoing early or urgent invasive management, from a United Kingdom National Health Service perspective.\ud
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METHODS: A decision-analytic model with lifelong time horizon was populated with event risks and resource use parameters derived from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial raw data. In a parallel analysis, key comparator strategy inputs came from Global Registry of Acute Coronary Events (GRACE) patients enrolled in the United Kingdom. Upstream and catheter laboratory-initiated GPI were assumed to be tirofiban and abciximab, respectively. Life expectancy of first-year survivors, unit costs, and health-state utilities came from United Kingdom sources. Costs and effects were discounted at 3.5%. Incremental cost-effectiveness ratios (ICERs) were expressed as cost per quality-adjusted life year (QALY) gained.\ud
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RESULTS: Higher acquisition costs for bivalirudin were partially offset by lower hospitalization and bleeding costs. In the ACUITY-based analysis, per-patient lifetime costs in the bivalirudin and heparin plus GPI strategies were £10,903 and £10,653, respectively. Patients survived 10.87 and 10.82 years on average, corresponding to 5.96 and 5.93 QALYs and resulting in an ICER of £9,906 per QALY gained. The GRACE-based ICER was £12,276 per QALY gained. In probabilistic sensitivity analysis, 72.1% and 67.0% of simulation results were more cost-effective than £20,000 per QALY gained, in the ACUITY-based and GRACE-based analyses, respectively. Additional scenario analyses implied that greater cost-effectiveness may be achieved in actual clinical practice.\ud
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CONCLUSIONS: Treating NSTE-ACS patients undergoing invasive management with bivalirudin is likely to represent a cost-effective option for the United Kingdom, when compared with the current practice of using heparin and a GP
“Brand” and performance in a new environment: Analysis of the law school market in Japan.

Using Japanese panel data for 2006-2009, this study attempts to examine how the pass rate of law school student taking the new bar examination influences the number of applicants for the law school in the following years. The major finding is that the higher the law school student pass rate, the greater the number of applicants for the law school becomes. Furthermore, the positive effect of the pass rate is larger for a prestigious university’s law school than for other schools. It follows that the “brand” and the school’s current performance are complementary in increasing demand for places in the law school.
A selection analysis of returns to education in China

This paper estimates the economic returns to education in China from 1989 to 2009, using the China Health and Nutrition Survey (CHNS) dataset. We find that education returns for one additional year generally increase from 2.6% in 1989 to 7.9% in 2009. Education returns, however, may reflect signals of innate ability, or the accumulation of human capital. Moreover, traditional Ordinary Least Square estimates may be biased by selection problems and mix-ups of age group heterogeneity. Hence, we estimate the marginal effects of schooling with the increasing labour markets experience, using the Heckman Selection Model. We find that the education returns for one additional year decline with labour markets experience, which support human capital hypothesis for all age groups except the group educated during the “Cultural Revolution”. Different dynamics of education returns in the four age groups are identified with large influence of institutional reforms in the labour markets, supporting the transition explanation of the evolution of education returns in China.
A clinical trial combining donor bone marrow infusion and heart transplantation: intermediate-term results.

BACKGROUND: Donor chimerism (the presence of donor cells of bone marrow origin) is present for years after transplantation in recipients of solid organs. In lung recipients, chimerism is associated with a lower incidence of chronic rejection. To augment donor chimerism with the aim to enhance graft acceptance and to reduce immunosuppression, we initiated a trial combining infusion of donor bone marrow with heart transplantation. Reported herein are the intermediate-term results of this ongoing trial. METHODS: Between September 1993 and August 1998, 28 patients received concurrent heart transplantation and infusion of donor bone marrow at 3.0 x 10(8) cells/kg (study group). Twenty-four contemporaneous heart recipients who did not receive bone marrow served as controls. All patients received an immunosuppressive regimen consisting of tacrolimus and steroids. RESULTS: Patient survival was similar between the study and control groups (86% and 87% at 3 years, respectively). However, the proportion of patients free from grade 3A rejection was higher in the study group (64% at 6 months) than in the control group (40%; P =.03). The prevalence of coronary artery disease was similar between the two groups (freedom from disease at 3 years was 78% in study patients and 69% in controls). Similar proportions of study (18%) and control (15%) patients exhibited in vitro evidence of donor-specific hyporesponsiveness. CONCLUSIONS: The infusion of donor bone marrow reduces the rate of acute rejection in heart recipients. Donor bone marrow may play an important role in strategies aiming to enhance the graft acceptance
Ideal minimal residual-based proper generalized decomposition for non-symmetric multi-field models – Application to transient elastodynamics in space-time domain

It is now well established that separated representations built with the help of proper generalized decomposition (PGD) can drastically reduce computational costs associated with solution of a wide variety of problems. However, it is still an open question to know if separated representations can be efficiently used to approximate solutions of hyperbolic evolution problems in space-time domain. In this paper, we numerically address this issue and concentrate on transient elastodynamic models. For such models, the operator associated with the space-time problem is non-symmetric and low-rank approximations are classically computed by minimizing the space-time residual in a natural L2 sense, yet leading to non optimal approximations in usual solution norms. Therefore, a new algorithm has been recently introduced by one of the authors and allows to find a quasi-optimal low-rank approximation a priori with respect to a target norm. We presently extend this new algorithm to multi-field models. The proposed algorithm is applied to elastodynamics formulated over space-time domain with the Time Discontinuous Galerkin method in displacement and velocity. Numerical examples demonstrate convergence of the proposed algorithm and comparisons are made with classical a posteriori and a priori approaches.Agence Nationale de la Recherche Française (ANR-10-COSI-0006
Measurement of the cross section for inclusive isolated-photon production in pp collisions at s=13 TeV using the ATLAS detector

Inclusive isolated-photon production in pp collisions at a centre-of-mass energy of is studied with the ATLAS detector at the LHC using a data set with an integrated luminosity of . The cross section is measured as a function of the photon transverse energy above in different regions of photon pseudorapidity. Next-to-leading-order perturbative QCD and Monte Carlo event-generator predictions are compared to the cross-section measurements and provide an adequate description of the data.We acknowledge the support of ANPCyT, Argentina; YerPhl, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COL-CIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DSM/IRFU, France; SRNSF, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, the Canada Council, CANARIE, CRC, Compute Canada, FQRNT, and the Ontario Innovation Trust, Canada; EPLANET, ERC, ERDF, FP7, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex and Idex, ANR, Region Auvergne and Fondation Partager le Savoir, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF; BSF, GIF and Minerva, Israel; BRF, Norway; CERCA Programme Generalitat de Catalunya, Generalitat Valenciana, Spain; the Royal Society and Leverhulme Trust, United Kingdom.info:eu-repo/semantics/publishedVersio
Getting more ‘carbon bang’ for your ‘buck’ in Acre State, Brazil

Acre State in Brazil is at the forefront of efforts to institutionalize jurisdictional-scale policies that aim to reduce emissions from deforestation and forest degradation (REDD +). Given limited REDD + funds and uncertain returns from alternative land uses, this paper estimates the minimum incentive payment Acre's government would have to pay forest landowners in each of its 22 municipalities to ensure forest conservation. Despite lower profits but with lower conversion costs and more stable returns over time relative to corn and coffee production, cattle pasture generates the highest returns in 19 municipalities. Municipalities are ranked according to their relative policy costs, a ranking which is compared to the distribution of forest carbon stocks across Acre. Finally, the relative cost per tonne of carbon is derived, which enables the identification of a group of 13 municipalities with the greatest potential for ‘carbon bang’ for a given ‘buck
Measurements of jet charge with dijet events in pp collisions at $\sqrt{s}$ = 8 TeV

Jet charge is an estimator of the electric charge of a quark, antiquark, or gluon initiating a jet. It is based on the momentum-weighted sum of the electric charges of the jet constituents. Measurements of three charge observables of the leading jet in transverse momentum $p_T$ are performed with dijet events. The analysis is carried out with ata collected by the CMS experiment at the CERN LHC in proton-proton collisions at $\sqrt{s}$ = 8 TeV corresponding to an integrated luminosity of 19.7fb$^{−1}$. The results are presented as a function of the $p_T$ of the leading jet and compared to predictions from leading- and next-to-leading-order event generators combined with parton showers. Measured jet charge distributions, unfolded for detector effects, are reported, which expand on previous measurements of the jet charge average and standard deviation in $pp$ collisions
A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors.

Cyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing molecular targets of coxibs for association with CAD. Given a broad spectrum of pleiotropic effects of coxibs, our intention was to narrow potential mechanisms affecting CAD risk as we hypothesized that the affected genes may also display genomic signals of coronary disease risk. A Drug Gene Interaction Database search identified 47 gene products to be affected by coxibs. We traced association signals in 200-kb regions surrounding these genes in 84,813 CAD cases and 202,543 controls. Based on a threshold of 1 × 10-5 (Bonferroni correction for 3131 haplotype blocks), four gene loci yielded significant associations. The lead SNPs were rs7270354 (MMP9), rs4888383 (BCAR1), rs6905288 (VEGFA1), and rs556321 (CACNA1E). By additional genotyping, rs7270354 at MMP9 and rs4888383 at BCAR1 also reached the established GWAS threshold for genome-wide significance. The findings demonstrate overlap of genes affected by coxibs and those mediating CAD risk and points to further mechanisms, which are potentially responsible for coxib-associated CAD risk. The novel approach furthermore suggests that genetic studies may be useful to explore the clinical relevance of off-target drug effects.Peer-reviewedPublisher Versio
The CARMENES search for exoplanets around M dwarfs. High-resolution optical and near-infrared spectroscopy of 324 survey stars

The CARMENES radial velocity (RV) survey is observing 324 M dwarfs to search for any orbiting planets. In this paper, we present the survey sample by publishing one CARMENES spectrum for each M dwarf. These spectra cover the wavelength range 520–1710 nm at a resolution of at least R >80 000, and we measure its RV, Hα emission, and projected rotation velocity. We present an atlas of high-resolution M-dwarf spectra and compare the spectra to atmospheric models. To quantify the RV precision that can be achieved in low-mass stars over the CARMENES wavelength range, we analyze our empirical information on the RV precision from more than 6500 observations. We compare our high-resolution M-dwarf spectra to atmospheric models where we determine the spectroscopic RV information content, Q, and signal-to-noise ratio. We find that for all M-type dwarfs, the highest RV precision can be reached in the wavelength range 700–900 nm. Observations at longer wavelengths are equally precise only at the very latest spectral types (M8 and M9). We demonstrate that in this spectroscopic range, the large amount of absorption features compensates for the intrinsic faintness of an M7 star. To reach an RV precision of 1 m s−1 in very low mass M dwarfs at longer wavelengths likely requires the use of a 10 m class telescope. For spectral types M6 and earlier, the combination of a red visual and a near-infrared spectrograph is ideal to search for low-mass planets and to distinguish between planets and stellar variability. At a 4 m class telescope, an instrument like CARMENES has the potential to push the RV precision well below the typical jitter level of 3–4 m s−1
Work at height : Neglect or improvisation in civil construction in Brazil and Uruguay?

Work at heights in the construction industry is responsible for a large number of occupational accidents. In Brazil, despite the relevant security-related legislation, it is possible to find situations of neglect and improvisation in various construction sites. The aim is to promote the debate about labor safety at construction sites. This article discusses the similarities between the labor safety laws of Brazil and Uruguay. After visits to construction sites in the cities of Recife (Brazil) and Montevideo (Uruguay) it was possible to observe both ergonomic and labor safety problems. After analyzing the perception of risk, improvement suggestions were generated
Comparison on efficiency of various techniques in treatment of waste and sewage water - A comprehensive review

In the present scenario, environmental laws have become stringent towards health, economy and reduction of pollution. The pollution is a result of discharge of various organic and inorganic substances into the environment. The sources of pollution include domestic agricultural and industrial water. Conventional techniques such as chemical precipitation, carbon adsorption, ion exchange, evaporations and membrane processes are found to be effective in treatment of waste and sewage water. Recently, biological treatments have gained popularity to remove toxic and other harmful substances. The objective of the paper is to make comprehensive review including the performance of each technique in treatment of waste and sewage water. The research directions are also suggested based on the review
Challenges and prospects for developing CdS/CdTe substrate solar cells on Mo foils.

ITO/ZnO/CdS/CdTe/Mo solar cells have been grown in the substrate configuration by a combination of close-space sublimation and RF sputtering. A peak efficiency of 8.01% was achieved. A two stage CdCl2 annealing process was developed, with the first stage contributing to CdTe doping and the second being linked to CdTe/CdS interdiffusion by secondary ion mass spectrometry analysis. The inclusion of a ZnO layer between CdS and ITO layers improved performance significantly (from η=6% to η=8%) by increasing the shunt resistance, RSH, from 563 Ω cm2 to 881 Ω cm2. Cross-sectional scanning electron microscopy highlighted the importance of the resistive ZnO layer as numerous pinholes and voids exist in the CdS film. Solar cell performance was also investigated as a function of CdTe thickness, with optimal thicknesses being in the range 3–6 μm. All devices were deemed to be limited principally by a non-Ohmic back contact, the Schottky barrier height being determined to be 0.51 eV by temperature dependent J–V measurements. Modelling of device performance using SCAPS predicted efficiencies as high as 11.3% may be obtainable upon formation of an Ohmic back-contact. SCAPS modelling also demonstrated that a quasi-Ohmic back-contact may be achievable via inclusion of a highly p-doped (~1018 cm−3) buffer layer, between CdTe and Mo, which also has an optimal electron affinity (4.2 eV). The evaluation of device processing and the in-depth characterisation presented here provides a number of insights towards the continued improvement of substrate cell performance
A randomised controlled trial of the use of a piece of commercial software for the acquisition of reading skills.

We report here the overall results of a cluster randomised controlled trial of the use of computer-aided instruction with 672 Year 7 pupils in 23 secondary school classes in the north of England. A new piece of commercial software, claimed on the basis of publisher testing to be effective in improving reading after just six weeks of use in the classroom, was compared over 10 weeks (one term) with standard practice in literacy provision. Pupil literacy was assessed before and after the trial, via another piece of commercial software testing precisely the kinds of skills covered by the pedagogical software. Both the treatment group and the comparison group improved their tested literacy. In a sense the publisher’s claim was justified. However, the comparison group improved their literacy scores considerably more than the treatment group, with a standardised improvement of +0.99 compared to +0.56 (overall “effect” size of −0.37), suggesting that the software approach yields no relative advantage for improvements, and may even disadvantage some pupils. On this evidence, the use of software, of a kind that is in very common use across schools in England, was a waste of resource. This could be an important corrective finding for an area of schooling that has been the focus of intense policy and practice attention. Of course, the software used has now been superseded by the same and different publishers. But the paper discusses the implications of these results for the use of such software to teach literacy more widely, for the way in which publisher claims are worded, and for the research community in relation to the feasibility of conducting pragmatic trials in school settings