pinecone/core-2020-05-10-deduplication huggingface dataset:
On decomposing net final values: EVA, SVA, and shadow project

A residual-income model, named Systemic Value Added (SVA), is proposed for decision-making purposes, based on a systemic approach introduced in Magni (2000, 2003, 2004). The model translates the
notion of residual income (excess profit) giving formal expression to a counterfactual alternative available to
the decision maker. Relations with other residual income models are studied, among which Stewart's Economic Value Added. The index here introduced differs from EVA in that it rests on a different interpretation of the notion of excess profit and is formally connected with the EVA model by means of a shadow project. The SVA is formally and conceptually threefold, in that it is economic, financial, accounting-flavoured. Some results are offered, providing su±cient and necessary conditions for decomposing Net Final Values. Relations between a project's SVA and its shadow project's EVA are shown, all results of Pressacco and Stucchi (1997) are proved by making use of the systemic approach and the shadow counterparts of those results are also shown.
Sequential Innovation and the Duration of Technology Licensing

We model an innovator's choice of payment scheme and duration as a joint decision in a multi-period licensing game with potential sequential innovations and some irreversibility of technology transfer. We find that it may be optimal to license the innovation for less than the full length of the patent and that royalty contracts can be used to overcome a time-consistency problem faced by the innovator. Our results suggest that licensing contracts based on royalty have a longer duration than fixed-fee licenses and are more likely to be used in industries where sequential innovations are frequent.
Real-Time Data Revisions and the PCE Measure of Inflation

This paper tracks data revisions in the Personal Consumption Expenditure using the exclusions-from-core inflation persistence model.  Keeping the number of observations the same, the regression parameters of earlier vintages of real-time data, beginning with vintage 1996:Q1, are tested for coincidence against the regression parameters of the last vintage of real-time data used in this paper, which is vintage 2008:Q2 in a parametric and two nonparametric frameworks.   The effects of data revisions are not detectable in the vast majority of cases in the parametric model, but the flexibility of the two nonparametric models is able to utilize the data revisions.
Predicted cross-sections for photon-induced particle emission

Cross-sections for the photon-induced particle-emission reactions (gamma,n), (gamma,p), and (gamma,alpha) are given for all natural isotopes from Ti to Bi. The target nuclei are assumed to be in their ground states, except for Ta-180 which is naturally occurring as the isomer Ta-180m. The cross-sections are calculated in a statistical model (Hauser-Feshbach) approach and covering an energy range from threshold up to 7.35 MeV above the threshold (14.7 MeV above threshold for (gamma,alpha) reactions). The results are intended to aid conception and analysis of experiments which can also be used to test the methods involved in predicting astrophysical reaction rates for nucleo-synthesis. (C) 2004 Elsevier Inc. All rights reserved
Enhanced tonic GABAA inhibition in typical absence epilepsy

The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired GABAergic inhibition remains an attractive hypothesis. In contrast, we show here that extrasynaptic GABAA receptor–dependent ‘tonic’ inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures. Increased tonic inhibition is due to compromised GABA uptake by the GABA transporter GAT–1 in the genetic models tested, and GAT–1 is critical in governing seizure genesis. Extrasynaptic GABAA receptors are a requirement for seizures in two of the best characterized models of absence epilepsy, and the selective activation of thalamic extrasynaptic GABAA receptors is sufficient to elicit both electrographic and behavioural correlates of seizures in normal animals. These results identify an apparently common cellular pathology in typical absence seizures that may have epileptogenic significance, and highlight novel therapeutic targets for the treatment of absence epilepsy.peer-reviewe
Prominent role of DPP III in the E2-mediated protection against hyperoxia in liver of female CBA/H mice

A number of age-related diseases have a low incidence in females, which is attributed to a protective effect of sex hormones. For instance, the female sex hormone estrogen (E2) has a well established cytoprotective effect against oxidative stress, which strongly contributes to ageing. However, the mechanism by which E2 exerts its protective activity remains elusive. \ud
In this study we address the question whether the E2-induced protective effect against hyperoxia is mediated by the Nrf-2/Keap-1 signaling pathway. In particular, we investigate the E2-induced expression and cellular distribution of DPP III monozinc exopeptidase, a member of the Nrf-2/Keap-1 pathway, upon hyperoxia treatment. \ud
We find that DPP III accumulates in the nucleus in response to hyperoxia. Further, we show that combined induction of hyperoxia and E2 administration have an additive effect on the nuclear accumulation of DPP III. The level of nuclear accumulation of DPP III is comparable to nuclear accumulation of Nrf-2 in healthy female mice exposed to hyperoxia. In ovariectomized females exposed to hyperoxia, supplementation of E2 induced upregulation of DPP III, Ho-1, Sirt-1 and downregulation of Ppar-γ. While other cytoprotective mechanisms cannot be excluded, these findings demonstrate a prominent role of DPP III, along with Sirt-1, in the E2-mediated protection against hyperoxi
Experimental study of blade thickness effects on the global and local performances of a Controlled Vortex Designed axial-flow fan

The purpose of this work is to study the effects of blade thickness on the performances of an axial-flow fan. Two fans that differ only in the thickness of their blades were studied. The first fan was designed to be part of the cooling system of an automotive vehicle power unit and has very thin blades. The second fan has much thicker blades compatible with the rotomoulding conception process. The global performances of the fans were measured in a test bench designed according to the ISO-5801 standard. The curve of aerodynamics characteristics (pressure head versus ow-rate) is slightly steeper for the fan with thick blades, and the nominal point is shifted towards lower flow-rates. The efficiency of the thick blades fan is lower than the efficiency of the fan with thin blades but remains high on a wider flow-rate range. The mean velocity field downstream of the rotors are very similar at nominal points with less centrifugation for the thick blades fan. The thick blades fan moreover maintains an axial exit-flow on a wider range of flow-rates. The main dierences concern local properties of the flow: Phase-averaged velocities and wall pressure fluctuations strongly differ at the nominal flow-rates. The total level of fluctuations is lower for the thick blades fan that for the thin blades fan and the spectral decomposition of the wall fluctuations and velocity signals reveal more harmonics for the thick blades fan, with less correlation between the different signals. For this kind of turbomachinery, the use of thick blades could lead to a good compromise between aerodynamic and acoustic performances, on a wider operating range
Evaluation of Trapped Magnetic Field Properties in Superconducting MgB$_2$ Bulk Magnets of Various Shapes by Finite Element Method

The trapped magnetic field properties of superconducting MgB2 bulk magnets with various shapes such as a triangular, a quadrangular, a hexangular bulk were calculated by the Finite Elements Method (FEM). The effect for the combination of several numbers of bulks was also investigated for several kinds of shapes to obtain large area of bulk surface in spite of one large bulk. In this calculation, the simple magnetization process replaced by the field-cool magnetization was used to obtain the equivalent distribution of the magnetic field, and the thermal equation in FEM was omitted. The trapped magnetic field for the triangular bulk by FEM was compared with the experimental result. It was found that the calculated results agreed well with the experimental result. The maximum trapped magnetic field was obtained in the cylindrical shape among several kinds of shapes. The trapped magnetic field was increased by the combination of multi-bulks. It was confirmed that the trapped magnetic field of the multi-bulks was larger than that of the single bulk. The trapped magnetic field increases with increasing the number of the bulks
A systematic approach to the comparison of roles in the software development processes

The vision of building a successful software product requires teams of individuals equipped with a wide range of social and technical skills. Furthermore, by combining these skills with appropriate job roles, we should be able to improve the productivity of a software organization. In order to identify and compare different roles in software development activities, we conduct a systematic comparison of software development models, covering traditional approaches through to agile techniques. To compare the roles in the literature with industrial software landscapes, we use data from a survey conducted on 266 software practitioners to ascertain job roles in two middle size software companies, one of which uses traditional methods and in particular ISO/IEC 12207 for managing their software development activities while other uses a tailored agile methodology. In light of our interviews, we found that based on project specific needs, the roles used in industry vary significantly from the roles defined in literature
Measurements of properties of the Higgs boson decaying into the four-lepton final state in pp collisions at sqrt(s) = 13 TeV

Properties of the Higgs boson are measured in the H to ZZ to 4l (l= e, mu) decay channel. A data sample of proton-proton collisions at sqrt(s) = 13 TeV, collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 35.9 inverse femtobarns is used. The signal strength modifier mu, defined as the ratio of the observed Higgs boson rate in the H to ZZ to 4l decay channel to the standard model expectation, is measured to be mu = 1.05 +0.19/-0.17 at m[H ]= 125.09 GeV, the combined ATLAS and CMS measurement of the Higgs boson mass. The signal strength modifiers for the individual Higgs boson production modes are also measured. The cross section in the fiducial phase space defined by the requirements on lepton kinematics and event topology is measured to be 2.92 +0.48/-0.44 (stat) +0.28/-0.24 (syst) fb, which is compatible with the standard model prediction of 2.76 +/- 0.14 fb. Differential cross sections are reported as a function of the transverse momentum of the Higgs boson, the number of associated jets, and the transverse momentum of the leading associated jet. The Higgs boson mass is measured to be m[H] = 125.26 +/- 0.21 GeV and the width is constrained using on-shell production to be Gamma[H] &lt; 1.10 GeV, at 95% confidence level
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

Aims/hypothesis: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in Diabetes (IMIDIA) consortium (www.imidia.org) established a comprehensive, unique multicentre biobank of human islets and pancreas tissues from organ donors and metabolically phenotyped pancreatectomised patients (PPP). Methods: Affymetrix microarrays were used to assess the islet transcriptome of islets isolated either by enzymatic digestion from 103 organ donors (OD), including 84 non-diabetic and 19 type 2 diabetic individuals, or by laser capture microdissection (LCM) from surgical specimens of 103 PPP, including 32 non-diabetic, 36 with type 2 diabetes, 15 with impaired glucose tolerance (IGT) and 20 with recent-onset diabetes (<1 year), conceivably secondary to the pancreatic disorder leading to surgery (type 3c diabetes). Bioinformatics tools were used to (1) compare the islet transcriptome of type 2 diabetic vs non-diabetic OD and PPP as well as vs IGT and type 3c diabetes within the PPP group; and (2) identify transcription factors driving gene co-expression modules correlated with insulin secretion ex vivo and glucose tolerance in vivo. Selected genes of interest were validated for their expression and function in beta cells. Results: Comparative transcriptomic analysis identified 19 genes differentially expressed (false discovery rate â\u89¤0.05, fold change â\u89¥1.5) in type 2 diabetic vs non-diabetic islets from OD and PPP. Nine out of these 19 dysregulated genes were not previously reported to be dysregulated in type 2 diabetic islets. Signature genes included TMEM37, which inhibited Ca2+-influx and insulin secretion in beta cells, and ARG2 and PPP1R1A, which promoted insulin secretion. Systems biology approaches identified HNF1A, PDX1 and REST as drivers of gene co-expression modules correlated with impaired insulin secretion or glucose tolerance, and 14 out of 19 differentially expressed type 2 diabetic islet signature genes were enriched in these modules. None of these signature genes was significantly dysregulated in islets of PPP with impaired glucose tolerance or type 3c diabetes. Conclusions/interpretation: These studies enabled the stringent definition of a novel transcriptomic signature of type 2 diabetic islets, regardless of islet source and isolation procedure. Lack of this signature in islets from PPP with IGT or type 3c diabetes indicates differences possibly due to peculiarities of these hyperglycaemic conditions and/or a role for duration and severity of hyperglycaemia. Alternatively, these transcriptomic changes capture, but may not precede, beta cell failure
Search for natural supersymmetry in events with top quark pairs and photons in pp collisions at √s = 8 TeV

Results are presented from a search for natural gauge-mediated supersymmetry (SUSY) in a scenario in which the top squark is the lightest squark, the next-to-lightest SUSY particle is a bino-like neutralino, and the lightest SUSY particle is the gravitino. The strong production of top squark pairs can produce events with pairs of top quarks and neutralinos, with each bino-like neutralino decaying to a photon and a gravitino. The search is performed using a sample of pp collision data accumulated by the CMS experiment at s√=8 TeV, corresponding to an integrated luminosity of 19.7 fb⁻¹. The final state consists of a lepton (electron or muon), jets, and one or two photons. The imbalance in transverse momentum in the events is compared with the expected spectrum from standard model processes. No excess event yield is observed beyond the expected background, and the result is interpreted in the context of a general model of gauge-mediated SUSY breaking that leads to exclusion of top squark masses below 650–730 GeV
Observation of Feshbach resonances between alkali and closed-shell atoms.

Magnetic Feshbach resonances allow control of the interactions between ultracold atoms1. They are an invaluable tool in studies of few-body and many-body physics2,3, and can be used to convert pairs of atoms into molecules4,5 by ramping an applied magnetic field across a resonance. Molecules formed from pairs of alkali atoms have been transferred to low-lying states, producing dipolar quantum gases6. There is great interest in making molecules formed from an alkali atom and a closed-shell atom such as ground-state Sr or Yb. Such molecules have both a strong electric dipole and an electron spin; they will open up new possibilities for designing quantum many-body systems7,8, and for tests of fundamental symmetries9. The crucial first step is to observe Feshbach resonances in the corresponding atomic mixtures. Very narrow resonances have been predicted theoretically10,11,12, but until now have eluded observation. Here we present the observation of magnetic Feshbach resonances of this type, for an alkali atom, Rb, interacting with ground-state Sr
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.Redox Biology (2017), 13: 94-16
Reducing Vulnerability to Hydro-Meteorological Extremes in Africa A Qualitative Assessment of National Climate Disaster Management Policies: Accounting for Heterogeneity

In Africa, hydro-meteorological disasters (HMDs) have hit with increasing frequency and magnitude in recent years, with detrimental impacts on local livelihoods.\ud
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African countries display a patchwork of national policies and institutional frameworks to address these rising HMDs.\ud
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This paper examines the heterogeneity that exists within Africa's institutional arrangements for climate-related disaster risk management, and introduces a three-partite policy classification that ranks each country as one of three disaster management policy types: the ‘Unprepared Firefighters’ (whose response to disasters is late, delayed and ineffective), the ‘Prepared Firefighters’ (for the most part effective disaster responders) and the ‘Disaster averters’ (who experienced a paradigm shift and moved focus away from the hazard itself towards a reduction of the underlying risk factors that cause disasters). Through extensive data mining, interviews and qualitative country assessments, we map where African countries lie on this spectrum of effective climate-related disaster risk management.\ud
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We find that African countries lay at different levels on the spectrum of effective disaster risk management. Across Africa, countries display differential progress in achieving the Hyogo Framework for Action goals and great variation and heterogeneity exists from country to country, one that calls for a concomitant heterogeneity in aid programs and initiatives meant to support comprehensive disaster risk reduction and climate change adaptation (DRR-CCA) in Africa.\ud
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In closing, this paper suggests ways to support African countries’ efforts towards effective disaster risk management and planning. It offers a qualitative method to continually assess developing countries’ progress in achieving the Hyogo Framework for Action goals, one that straddles top-down country self-reporting and bottom-up civil society assessment.\u
Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits.

Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with genetically engineered lines of mice optimized to study single gene function. Here, we systematically acquired metabolic phenotypes by using the EUMODIC EMPReSS protocols across a large panel of isogenic but diverse strains of mice (BXD type) to study the genetic control of metabolism. We generated and analyzed 140 classical phenotypes and deposited these in an open-access web service for systems genetics (www.genenetwork.org). Heritability, influence of sex, and genetic modifiers of traits were examined singly and jointly by using quantitative-trait locus (QTL) and expression QTL-mapping methods. Traits and networks were linked to loci encompassing both known variants and novel candidate genes, including alkaline phosphatase (ALPL), here linked to hypophosphatasia. The assembled and curated phenotypes provide key resources and exemplars that can be used to dissect complex metabolic traits and disorders
Geometrical tests of cosmological models. II. Calibration of rotational
  widths and disc scaling relations

This series of papers is dedicated to a new technique to select galaxies that
can act as standard rods and standard candles in order to perform geometrical
tests on large samples of high redshift galaxies to constrain different
cosmological parameters. The goals of this paper are (1) to compare different
rotation indicators in order to understand the relation between rotation
velocities extracted from observations of the Halpha line and the [OII]3727
line, and (2) determine the scaling relations between physical size, surface
brightness and magnitude of galaxies and their rotation velocity using the
SFI++, a large catalog of nearby galaxies observed at I-band. A good
correlation is observed between the rotation curve-derived velocities of the
Halpha and [OII] observations, as well as between those calculated from
velocity histograms, justifying the direct comparison of velocities measured
from Halpha rotation curves in nearby galaxies and from [OII] line widths at
higher redshifts. To provide calibration for the geometrical tests, we give
expressions for the different scaling relations between properties of galaxies
(size, surface brightness, magnitude) and their rotation speeds. Apart from the
Tully-Fisher relation, we derive the size-rotation velocity and surface
brightness-rotation velocity relations with unprecedentedly small scatters. We
show how the best size-rotation velocity relation is derived when size is
estimated not from disc scale lengths but from the isophotal diameter r23.5,
once these have been corrected for inclination and extinction effects.Comment: 14 pages and 10 figures. A&A submitte