pinecone/core-2020-05-10-deduplication huggingface dataset:
Devising quality assurance procedures for assessment of legacy geochronological data relating to deglaciation of the last British-Irish Ice Sheet

This contribution documents the process of assessing the quality of data within a compilation of legacy geochronological data relating to the last British-Irish Ice Sheet, a task undertaken as part of a larger community-based project (BRITICE-CHRONO) that aims to improve understanding of the ice sheet's deglacial evolution. As accurate reconstructions depend on the quality of the available data, some form of assessment is needed of the reliability and suitability of each given age(s) in our dataset. We outline the background considerations that informed the quality assurance procedures devised given our specific research question. We describe criteria that have been used to make an objective assessment of the likelihood that an age is influenced by the technique specific sources of geological uncertainty. When these criteria were applied to an exisiting database of all geochronological data relating to the last British-Irish Ice Sheet they resulted in a significant reduction in data considered suitable for synthesis. The assessed data set was used to test a Bayesian approach to age modelling ice stream retreat and we outline our procedure that allows us to minimise the influence of potentially erroneous data and maximise the accuracy of the resultant age models.publishersversionPeer reviewe
Evaluating the potential for the continuous processing of pharmaceutical products - a supply network perspective

This paper presents an approach to evaluating the potential supply chain benefits of adopting continuous processing technologies for a diverse set of pharmaceutical products. The approach integrates upstream ‘continuous’ processing considerations for the production of active ingredients and final product formulation, with the downstream implications for packing and distribution. Currently, these upstream and downstream operations largely operate as decoupled operations with independent coordination and governance mechanisms, and the approach presented in this paper identifies opportunities for more case-specific integrated end-to-end supply chains enabled by continuous flow technologies. Three specific product (and corresponding processing technology) case studies are used to demonstrate the utility of the approach in assessing the supply network and system integration opportunities that emerge from the continuous processing of pharmaceutical products.We would like to acknowledge the support from the UK’s EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation, and the Advanced Manufacturing Supply Chain Initiative (AMSCI) programme Remedies Project.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.cep.2015.07.01
The eruptive history and magmatic evolution of Aluto volcano : new insights into silicic peralkaline volcanism in the Ethiopian rift

W.H., D.M.P., T.A.M. and J.B. are supported by and contribute to the NERC Centre for the Observation and Modelling of Earthquakes, Volcanoes and Tectonics (COMET). W.H. was funded by NERC studentship, NE/J5000045/1. Additional funding for the project was provided by: University College and the Department of Zoology (Boise Trust Fund) at the University of Oxford, as well as the Geological Remote Sensing Group, the Edinburgh Geological Society and the Leverhulme Trust.The silicic peralkaline volcanoes of the East African Rift are some of the least studied volcanoes on Earth. Here we bring together new constraints from fieldwork, remote sensing, geochronology and geochemistry to present the first detailed account of the eruptive history of Aluto, a restless silicic volcano located in a densely populated section of the Main Ethiopian Rift. Prior to the growth of the Aluto volcanic complex (before 500 ka) the region was characterized by a significant period of fault development and mafic fissure eruptions. The earliest volcanism at Aluto built up a trachytic complex over 8 km in diameter. Aluto then underwent large-volume ignimbrite eruptions at 316 ± 19 ka and 306 ± 12 ka developing a ~ 42 km2 collapse structure. After a hiatus of ~ 250 ka, a phase of post-caldera volcanism initiated at 55 ± 19 ka and the most recent eruption of Aluto has a radiocarbon age of 0.40 ± 0.05 cal. ka BP. During this post-caldera phase highly-evolved peralkaline rhyolite lavas, ignimbrites and pumice fall deposits have erupted from vents across the complex. Geochemical modelling is consistent with rhyolite genesis from protracted fractionation (> 80%) of basalt that is compositionally similar to rift-related basalts found east of the complex. Based on the style and volume of recent eruptions we suggest that silicic eruptions occur at an average rate of 1 per 1000 years, and that future eruptions of Aluto will involve explosive emplacement of localised pumice cones and effusive obsidian coulees of volumes in the range 1–100 × 106 m3.Publisher PDFPeer reviewe
Gender differences in test anxiety and their impact on higher education students' academic achievement

Test anxiety has detrimental effects on the academic performance of many university students. Moreover, female students usually report higher levels of test anxiety than do their male peers. The present study examined gender differences in test, trait, and math anxiety among university students, as well as differences in their academic achievement. Participants were 168 students from the University of Barcelona, all of whom completed measures of test anxiety, math anxiety, and trait anxiety. They were also asked about their expected level of anxiety when faced with four specific test situations: multiple-choice, open-question, oral presentation, and an exam involving calculations. At the end of the course in which they were enrolled, students were assessed through a multiple-choice and an open-question exam. Compared with their male counterparts, female students reported higher levels of test, math, and trait anxiety, as well as greater expected anxiety in three of the four test situations considered. However, females did not show lower academic achievement than male students in either the open-question or the multiple-choice exams. These results are discussed in terms of gender differences in socialization patterns and coping styles
Screening of the \u27pathogen box\u27 identifies an approved pesticide with major anthelmintic activity against the barber\u27s pole worm

There is a substantial need to develop new medicines against parasitic diseases via public-private partnerships. Based on high throughput phenotypic screens of largely protozoal pathogens and bacteria, the Medicines for Malaria Venture (MMV) has recently assembled an open-access \u27Pathogen Box\u27 containing 400 well-curated chemical compounds. In the present study, we tested these compounds for activity against parasitic stages of the nematode Haemonchus contortus (barber\u27s pole worm). In an optimised, whole-organism screening assay, using exsheathed third-stage (xL3) and fourth-stage (L4) larvae, we measured the inhibition of larval motility, growth and development of H.&nbsp;contortus. We also studied the effect of the \u27hit\u27 compound on mitochondrial function by measuring oxygen consumption. Among the 400 Pathogen Box compounds, we identified one chemical, called tolfenpyrad (compound identification code: MMV688934) that reproducibly inhibits xL3 motility as well as L4 motility, growth and development, with IC50 values ranging between 0.02 and 3&nbsp;&mu;M. An assessment of mitochondrial function showed that xL3s treated with tolfenpyrad consumed significantly less oxygen than untreated xL3s, which was consistent with specific inhibition of complex I of the respiratory electron transport chain in arthropods. Given that tolfenpyrad was developed as a pesticide and has already been tested for absorption, distribution, excretion, biotransformation, toxicity and metabolism, it shows considerable promise for hit-to-lead optimisation and/or repurposing for use against H.&nbsp;contortus and other parasitic nematodes. Future work should assess its activity against hookworms and other pathogens that cause neglected tropical diseases
From dense hot Jupiter to low-density Neptune : the discovery of WASP-127b, WASP-136b, and WASP-138b

We report three newly discovered exoplanets from the SuperWASP survey. WASP-127b is a heavily inflated super-Neptune of mass 0.18 ± 0.02 MJ and radius 1.37 ± 0.04 RJ. This is one of the least massive planets discovered by the WASP project. It orbits a bright host star (Vmag = 10.16) of spectral type G5 with a period of 4.17 days. WASP-127b is a low-density planet that has an extended atmosphere with a scale height of 2500 ± 400 km, making it an ideal candidate for transmission spectroscopy. WASP-136b and WASP-138b are both hot Jupiters with mass and radii of 1.51 ± 0.08 MJ and 1.38 ± 0.16 RJ, and 1.22 ± 0.08 MJ and 1.09 ± 0.05 RJ, respectively. WASP-136b is in a 5.22-day orbit around an F9 subgiant star with a mass of 1.41 ± 0.07 M⊙ and a radius of 2.21 ± 0.22 R⊙. The discovery of WASP-136b could help constrain the characteristics of the giant planet population around evolved stars. WASP-138b orbits an F7 star with a period of 3.63 days. Its radius agrees with theoretical values from standard models, suggesting the presence of a heavy element core with a mass of ∼ 10 M⊕. The discovery of these new planets helps in exploring the diverse compositional range of short-period planets, and will aid our understanding of the physical characteristics of both gas giants and low-density planets.PostprintPeer reviewe
Universality of decay-out of superdeformed bands in the 190 mass region

AbstractSuperdeformed nuclei in the 190 mass region exhibit a striking universality in their decay-out profiles. We show that this universality can be explained in the two-level model of superdeformed decay as related to the strong separation of energy scales: a higher scale related to the nuclear interactions, and a lower scale caused by electromagnetic decay. Decay-out can only occur when separate conditions in both energy regimes are satisfied, strongly limiting the collective degrees of freedom available to the decaying nucleus. Furthermore, we present the results of the two-level model for all decays for which sufficient data are known, including statistical extraction of the matrix element for tunneling through the potential barrier
Two cases of culture proven Mycobacterium tuberculosis presenting with a broad-complex tachycardia and non-caseating granulomas

AbstractTuberculosis is a leading cause of death worldwide. It affects pulmonary and extra-pulmonary sites with a multitude of differing presentations. In this report, we describe two cases in which TB causes myopericarditis and presents with a broad-complex tachycardia that did not respond typically to standard anti-arrhythmic therapy; a very rare presentation with limited description in the literature. Both patients required extensive investigation culminating in identifying lymph nodes amenable to biopsy under endobronchial ultrasound guidance. It was not until both patients received anti-tuberculous chemotherapy alongside anti-arrhythmic management that any improvement to their condition was witnessed. Therefore, we recommend that the clinician should have a high index of suspicion for TB in any patient presenting with a broad-complex tachycardia that is not responding to standard first line management, especially if the patient is from a high risk background. We recommend an active diagnostic pursuit, and lymph node biopsy under endobronchial ultrasound guidance
Cysteine Proteinase-1 and Cut Protein Isoform Control Dendritic Innervation of Two Distinct Sensory Fields by a Single Neuron

SummaryDendrites often exhibit structural changes in response to local inputs. Although mechanisms that pattern and maintain dendritic arbors are becoming clearer, processes regulating regrowth, during context-dependent plasticity or after injury, remain poorly understood. We found that a class of Drosophila sensory neurons, through complete pruning and regeneration, can elaborate two distinct dendritic trees, innervating independent sensory fields. An expression screen identified Cysteine proteinase-1 (Cp1) as a critical regulator of this process. Unlike known ecdysone effectors, Cp1-mutant ddaC neurons pruned larval dendrites normally but failed to regrow adult dendrites. Cp1 expression was upregulated/concentrated in the nucleus during metamorphosis, controlling production of a truncated Cut homeodomain transcription factor. This truncated Cut, but not the full-length protein, allowed Cp1-mutant ddaC neurons to regenerate higher-order adult dendrites. These results identify a molecular pathway needed for dendrite regrowth after pruning, which allows the same neuron to innervate distinct sensory fields
Spherically symmetric Yang–Mills solutions in a 5-dimensional (Anti-) de Sitter space–time

AbstractWe consider an Einstein–Yang–Mills Lagrangian in a five-dimensional space–time including a cosmological constant. Assuming all fields to be independent of the extra coordinate, a dimensional reduction leads to an effective (3+1)-dimensional Einstein–Yang–Mills–Higgs dilaton model where the cosmological constant induces a Liouville potential in the dilaton field. We construct spherically symmetric solutions analytically in specific limits and study the generic solutions for vanishing dilaton coupling numerically. We find that in this latter case the solutions bifurcate with the branch of (Anti-) de Sitter–Reissner–Nordström ((A)dSRN) solutions
Dirac equation on coordinate dependent noncommutative space–time

AbstractIn this paper we discuss classical aspects of spinor field theory on the coordinate dependent noncommutative space–time. The noncommutative Dirac equation describing spinning particle in an external vector field and the corresponding action principle are proposed. The specific choice of a star product allows us to derive a conserved noncommutative probability current and to obtain the energy–momentum tensor for free noncommutative spinor field. Finally, we consider a free noncommutative Dirac fermion and show that if the Poisson structure is Lorentz-covariant, the standard energy–momentum dispersion relation remains valid
Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo

SummaryBreaching endothelial cells (ECs) is a decisive step in the migration of leukocytes from the vascular lumen to the extravascular tissue, but fundamental aspects of this response remain largely unknown. We have previously shown that neutrophils can exhibit abluminal-to-luminal migration through EC junctions within mouse cremasteric venules and that this response is elicited following reduced expression and/or functionality of the EC junctional adhesion molecule-C (JAM-C). Here we demonstrate that the lipid chemoattractant leukotriene B4 (LTB4) was efficacious at causing loss of venular JAM-C and promoting neutrophil reverse transendothelial cell migration (rTEM) in vivo. Local proteolytic cleavage of EC JAM-C by neutrophil elastase (NE) drove this cascade of events as supported by presentation of NE to JAM-C via the neutrophil adhesion molecule Mac-1. The results identify local LTB4-NE axis as a promoter of neutrophil rTEM and provide evidence that this pathway can propagate a local sterile inflammatory response to become systemic
Measurement of the centrality dependence of J/ψ yields and observation of Z production in lead–lead collisions with the ATLAS detector at the LHC

AbstractUsing the ATLAS detector, a centrality-dependent suppression has been observed in the yield of J/ψ mesons produced in the collisions of lead ions at the Large Hadron Collider. In a sample of minimum-bias lead–lead collisions at a nucleon–nucleon centre of mass energy sNN=2.76 TeV, corresponding to an integrated luminosity of about 6.7 μb−1, J/ψ mesons are reconstructed via their decays to μ+μ− pairs. The measured J/ψ yield, normalized to the number of binary nucleon–nucleon collisions, is found to significantly decrease from peripheral to central collisions. The centrality dependence is found to be qualitatively similar to the trends observed at previous, lower energy experiments. The same sample is used to reconstruct Z bosons in the μ+μ− final state, and a total of 38 candidates are selected in the mass window of 66 to 116 GeV. The relative Z yields as a function of centrality are also presented, although no conclusion can be inferred about their scaling with the number of binary collisions, because of limited statistics. This analysis provides the first results on J/ψ and Z production in lead–lead collisions at the LHC
Neuropsychological predictors of response to randomized treatment in obsessive–compulsive disorder

AbstractObjectiveTo identify neuropsychological predictors of treatment response to cognitive–behavioral therapy (CBT) and fluoxetine in treatment-naïve adults with obsessive–compulsive disorder (OCD).MethodThirty-eight adult outpatients with OCD underwent neuropsychological assessment, including tasks of intellectual function, executive functioning and visual and verbal memory, before randomization to a 12-week clinical trial of either CBT or fluoxetine. Neuropsychological measures were used to identify predictors of treatment response in OCD.ResultsNeuropsychological measures that predicted a better treatment response to either CBT or fluoxetine were higher verbal IQ (Wechsler Abbreviated Scale of Intelligence) (p=0.008); higher verbal memory on the California Verbal Learning Test (p=0.710); shorter time to complete part D (Dots) (p<0.001), longer time to complete part W (Words) (p=0.025) and less errors on part C (Colors) (p<0.001) in the Victoria Stroop Test (VST). Fewer perseverations on the California Verbal Learning Test, a measure of mental flexibility, predicted better response to CBT, but worse response to fluoxetine (p=0.002).ConclusionIn general, OCD patients with better cognitive and executive abilities at baseline were more prone to respond to either CBT or fluoxetine. Our finding that neuropsychological measures of mental flexibility predicted response to treatment in opposite directions for CBT and fluoxetine suggests that OCD patients with different neuropsychological profiles may respond preferentially to one type of treatment versus the other. Further studies with larger samples of OCD patients are necessary to investigate the heuristic value of such findings in a clinical context
Petrogenesis of mafic collision zone magmatism: The Armenian sector of the Turkish–Iranian Plateau

AbstractThe Turkish–Iranian Plateau grew after the Middle Miocene following the initial Paleogene Arabia–Eurasia collision. Authors attribute uplift to break-off of the southern Neo-Tethys slab beneath the Bitlis–Zagros Suture at ~15–10Ma, coupled with continued plate convergence and regional crustal shortening. Since this time there has been an upsurge in mantle-derived collision magmatism over large parts of NW Iran, Eastern Anatolia and the Lesser Caucasus, potentially hundreds of kilometres from the site of southern Neo-Tethys slab break-off, >10Myr after the proposed break-off event. Whole rock elemental and Sr–Nd–Pb–Hf isotope data are presented for <3Ma trachy-basalt to trachy-basaltic andesite lavas erupted in Armenia in the South Caucasus. Samples formed by <5% melting of fertile subduction-modified spinel-facies lithospheric mantle, and few display elemental or isotopic evidence for contamination by the 45-km thick Mesozoic–Paleogene arc crust or South Armenian Block continental crust. Recent magmatic activity in Armenia may not be a direct consequence of southern Neo-Tethys slab break-off 300–450km away, beneath the Bitlis Suture. Late Miocene break-off of a second (northern Neo-Tethys) slab beneath the Pontide Arc may have allowed asthenospheric upwelling over a wider area than was affected by southern Neo-Tethyan break-off. However, whole-scale delamination of mantle lithosphere is ruled out due to the modest degrees of partial melting, a lack of asthenospheric components and limited crustal involvement in magmatism. Small-scale sub-lithospheric convection may be complementary to break-off, causing localised removal of lithospheric mantle and aiding the occurrence of melting for a significant time interval after the break-off event(s). Collision magmas such as those in Armenia represent mantle-derived additions to continental crust, enriched in incompatible elements but with Th/La ratios≤0.2, much lower than those calculated for continental crust (0.25–0.3). Collision magmatism in Turkic-style orogens must be balanced by infra-crustal recycling and delamination to produce bulk continental crust
Electroweak corrections to Z-boson hadroproduction at finite transverse momentum

AbstractWe calculate the full one-loop electroweak radiative corrections, of O(α2αs), to the cross section of single Z-boson inclusive hadroproduction at finite transverse momentum (pT). This includes the O(α) corrections to Z+j production, the O(αs) corrections to Z+γ production, and certain QCD-electroweak interference contributions involving a single quark trace. We recover the QCD and purely weak corrections and study the QED corrections and the QCD-electroweak interference contributions for the first time. We also consider direct and resolved photoproduction in elastic and inelastic scattering. We present pT and rapidity distributions for the experimental conditions at the Fermilab Tevatron and the CERN LHC and assess the significance of the various contributions
Modifiable Arousal in Attention-Deficit/Hyperactivity Disorder and Its Etiological Association With Fluctuating Reaction Times

AbstractBackgroundCognitive theories of attention-deficit/hyperactivity disorder (ADHD) propose that high within-subject fluctuations of cognitive performance in ADHD, particularly reaction time (RT) variability (RTV), may reflect arousal dysregulation. However, direct evidence of arousal dysregulation and how it may account for fluctuating RTs in ADHD is limited. We used skin conductance (SC) as a measure of peripheral arousal and aimed to investigate its phenotypic and familial association with RTV in a large sample of ADHD and control sibling pairs.MethodsAdolescents and young adults (N = 292), consisting of 73 participants with ADHD and their 75 siblings, and 72 controls and their 72 siblings, completed the baseline (slow, unrewarded) and fast-incentive conditions of a RT task, while SC was simultaneously recorded.ResultsA significant group-by-condition interaction emerged for SC level (SCL). Participants with ADHD had decreased SCL, compared with controls, in the baseline condition but not the fast-incentive condition. Baseline SCL was negatively associated with RTV, and multivariate model fitting demonstrated that the covariance of SCL with RTV, and of SCL with ADHD, was mostly explained by shared familial effects.ConclusionsADHD is associated with decreased, but modifiable, tonic peripheral arousal. A shared familial cause underlies the relationship between arousal and RTV and between arousal and ADHD. Given the malleability of SCL, if our findings are replicated, it warrants further exploration as a potential treatment target for ADHD