pinecone/core-2020-05-10-deduplication huggingface dataset:
Aspects of service-dominant logic and its implications for tourism management: Examples from the hotel industry

This paper introduces the concept of service-dominant logic as a research paradigm in marketing management. It does so in the context of tourism management‟s need to engage with wider debates within the mainstream management literature. Moreover it demonstrates the importance of service-dominant logic in uncovering the role played by co-production and co-creation in the tourism industry. These ideas are developed in detail through a case study of the UK hotel industry that draws on new empirical research undertaken by the authors
On the spatio-temporal distribution of M 7.0+ worldwide seismicity with a non-parametric statistics

The aim of this paper is to provide some constrains on the time behavior of earthquake generation mechanism, through the usage of a non-parametric statistics that leads up to the empirical estimation of the hazard function. The results indicate that the most characterizing temporal feature for large (M 7.0+) worldwide shallow earthquake occurrence is a clustering lasting few years, indicating that the probability of earthquake occurrence is higher immediately after the occurrence of an event. After that, the process becomes almost time independent, as in a Poisson process. Remarkably, this time clustering is very similar to what previously found for different spatio-magnitude windows, and it does not seem to depend on the tectonic style of the region. This may support the hypothesis of an universal law for earthquake occurrence
Prognostic value of mid-regional pro-adrenomedullin in patients with acute myocardial infarction. Leicester Acute Myocardial Infarction Peptide (LAMP) study.

This is the authors' final draft of the paper published as Journal of the American College of Cardiology, 2007, 49(14), pp.1525-1535.  The final published version is available on Science Direct, doi:10.1016/j.jacc.2006.12.038.Background: Adrenomedullin(ADM) is elevated in heart failure(HF) and after acute myocardial infarction(AMI). Another part of its precursor, mid-regional proADM(MR-proADM) is more stable in circulation and ex-vivo. We investigated the cardiovascular prognostic value post-AMI of MR-proADM and compared it to N-terminal B-type natriuretic peptide (NTproBNP), a marker of death and HF.\ud
Methods: We measured plasma MR-proADM and NTproBNP in 983 consecutive post-AMI patients (721 men, mean age 65.0±(SD)12.2 years), 3-5 days after chest pain onset.\ud
Results: There were 101 deaths and 49 readmissions with HF during follow up (median 342, range 0-764 days). MR-proADM was raised in patients with death or HF compared to survivors (median [range]nmol/L, 1.19[0.09-5.39] vs. 0.71[0.25-6.66]; p<0.0001). Using a multivariate binary logistic model, log MR-proADM (OR 4.22) and log NTproBNP (OR 3.20) were significant independent predictors of death or HF (with creatinine, age, gender and past history of AMI). The areas under the receiver-operating curve (AUC) for MR-proADM, NTproBNP and the logistic model with both markers were 0.77, 0.79 and 0.84 respectively. Cox models for the predictors of death or HF revealed the same variables (including log MR-proADM (HR 3.63), log NTproBNP (HR 2.67)). MR-proADM provided further risk stratification in those patients who had NTproBNP level above the median (p<0.0001). Findings were similar for death and HF as individual endpoints.\ud
Conclusions: The adrenomedullin system is activated post-AMI. MR-proADM is a powerful predictor of adverse outcome especially in those with an elevated NTproBNP. MR-proADM may represent a clinically useful marker of prognosis after AMI.Peer reviewedPost prin
Precise QCD predictions for the production of Higgs + jet final states.

We compute the cross section and differential distributions for the production of a Standard Model Higgs boson in association with a hadronic jet to next-to-next-to-leading order in quantum chromodynamics (QCD). In Higgs boson studies at the LHC, final states containing one jet are a dominant contribution to the total event rate, and their understanding is crucial for improved determinations of the Higgs boson properties. We observe substantial higher order corrections to transverse momentum spectra and rapidity distributions in Higgs-plus-one-jet final states. Their inclusion stabilises the residual theoretical uncertainty of the predictions around 9%, thereby providing important input to precision studies of the Higgs boson
Anomalous recurrence properties of many-dimensional zero-drift random walks.

Famously, a d-dimensional, spatially homogeneous random walk whose increments are nondegenerate, have finite second moments, and have zero mean is recurrent if d∈{1,2}, but transient if d≥3. Once spatial homogeneity is relaxed, this is no longer true. We study a family of zero-drift spatially nonhomogeneous random walks (Markov processes) whose increment covariance matrix is asymptotically constant along rays from the origin, and which, in any ambient dimension d≥2, can be adjusted so that the walk is either transient or recurrent. Natural examples are provided by random walks whose increments are supported on ellipsoids that are symmetric about the ray from the origin through the walk's current position; these elliptic random walks generalize the classical homogeneous Pearson‒Rayleigh walk (the spherical case). Our proof of the recurrence classification is based on fundamental work of Lamperti
Identification of spin wave modes in yttrium iron garnet strongly coupled to a co-axial cavity.

We demonstrate, at room temperature, the strong coupling of the fundamental and
non-uniform magnetostatic modes of an yttrium iron garnet (YIG) ferrimagnetic
sphere to the electromagnetic modes of a co-axial cavity. The well-de ned  eld pro le
within the cavity yields a speci c coupling strength for each magnetostatic mode. We
experimentally measure the coupling strength for the di erent magnetostatic modes
and, by calculating the expected coupling strengths, are able to identify the modes
themselves.We would like to acknowledge support from Hitachi Cambridge Laboratory, and EPSRC Grant No. EP/K027018/1. A.J.F. is supported by a Hitachi Research fellowship.This is the author accepted manuscript. The final version is available from AIP at http://scitation.aip.org/content/aip/journal/jap/117/5/10.1063/1.4907694#fulltextAbstract
Dynamical Restoration of Z_N Symmetry in SU(N)+Higgs Theories

We study the Z_N symmetry in SU(N)+Higgs theories with the Higgs field in the
fundamental representation. The distributions of the Polyakov loop show that
the Z_N symmetry is explicitly broken in the Higgs phase. On the other hand,
inside the Higgs symmetric phase the Polyakov loop distributions and other
physical observables exhibit the Z_N symmetry. This effective restoration of
the Z_N symmetry changes the nature of the confinement-deconfinenement
transition. We argue that the Z_N symmetry will lead to time independent
topological defect solutions in the Higgs symmetric deconfined phase which will
play important role at high temperatures.Comment: 13 pages, 4 figure
On Bulk Singularity Structures and all order $\alpha'$ Contact Terms of
  BPS String Amplitudes

The entire form of the amplitude of three SYM ( involving two transverse
scalar fields, a gauge field) and a potential $C_{n-1}$ Ramond-Ramond (RR) form
field is found out. We first derive $<V_{C^{-2}} V_{A^{0}} V_{\phi ^{0}}
V_{\phi ^{0}}>$ and then start constructing an infinite number of $t,s$ channel
bulk singularity structures by means of all order $\alpha'$ corrections to
pull-back of brane in an Effective Field Theory (EFT). Due to presence of the
complete form of S-matrix, several new contact interactions as well as new
couplings are explored. It is also shown that these couplings can be verified
at the level of EFT by either the combinations of Myers terms, pull-back,
Taylor expanded of scalar fields or the mixed combination of the couplings of
this paper as well as employed Bianchi identities. For the first time, we also
derive the algebraic and the complete form of the integrations for some
arbitrary combinations of Mandelstam variables and for the most general case
$\int d^2z |1-z|^{a} |z|^{b} (z - \bar{z})^{c} (z + \bar{z})^{3}$ on upper half
plane as well.Comment: 21 pages, Latex file, no figure, Published version in PL
Exploring the variation in implementation of a COPD disease management programme and its impact on health outcomes: a post hoc analysis of the RECODE cluster randomised trial

Contains fulltext :
                  152216.pdf (publisher's version ) (Open Access)This study aims to (1) examine the variation in implementation of a 2-year chronic obstructive pulmonary disease (COPD) management programme called RECODE, (2) analyse the facilitators and barriers to implementation and (3) investigate the influence of this variation on health outcomes. Implementation variation among the 20 primary-care teams was measured directly using a self-developed scale and indirectly through the level of care integration as measured with the Patient Assessment of Chronic Illness Care (PACIC) and the Assessment of Chronic Illness Care (ACIC). Interviews were held to obtain detailed information regarding the facilitators and barriers to implementation. Multilevel models were used to investigate the association between variation in implementation and change in outcomes. The teams implemented, on average, eight of the 19 interventions, and the specific package of interventions varied widely. Important barriers and facilitators of implementation were (in)sufficient motivation of healthcare provider and patient, the high starting level of COPD care, the small size of the COPD population per team, the mild COPD population, practicalities of the information and communication technology (ICT) system, and hurdles in reimbursement. Level of implementation as measured with our own scale and the ACIC was not associated with health outcomes. A higher level of implementation measured with the PACIC was positively associated with improved self-management capabilities, but this association was not found for other outcomes. There was a wide variety in the implementation of RECODE, associated with barriers at individual, social, organisational and societal level. There was little association between extent of implementation and health outcomes
Is the EuroSCORE II best suited for reoperative risk estimation in patients with structural deterioration of aortic bioprostheses?

International audienceOperative risk prediction systems (logistic EuroSCORE I, EuroSCORE II and STS Score) are employed together with multidisciplinary discussion to contraindicate conventional surgery in patients with valvular heart disease and propose the employment of alternative transcatheter procedures. The EuroSCORE I has been reported to underperform in these circumstances; we hypothesize that the EuroSCORE II is best suited for the stratification of risk in patients with structural deterioration (SVD) of valvular bioprostheses and potential candidates to the Valve-in-Valve procedure (deployment of a transcatheter valve within a failing valvular bioprosthesis). A multi-institutional collaboration is required to fully address such hypothesis. Therefore, we performed a preliminary validation study by retrieval of the complete records of 81 patients undergoing reoperative aortic valve replacement for preoperative diagnosis of bioprosthetic SVD at our Institution. Logistic EuroSCORE I, EuroSCORE II and STS Score were calculated by preoperatively available data. Faced to an observed reoperative mortality of 4.9%, average EuroSCORE I was 15.8%±13.4, EuroSCORE II was 7.3%±7.4 and the STS Score was 15%±9.8. The three systems provided sufficient adequacy (Hosmer-Lemeshow p=0.847, p=0.999 and p=0.9948, respectively). Yet, the area under the ROC curve was significantly higher for the EuroSCORE II (0.9903) vs. the EuroSCORE I (0.8994) (p=0.044). The STS Score yielded an intermediate figure (0.9643). The odds ratios (logistic regression) were 1.079 for EuroSCORE I, 1.223 for the STS Score and 1.474 for EuroSCORE II. The three investigated algorithms showed reasonable calibration in the prediction of mortality for reoperative aortic valve replacement, but they evenly overestimated the observed mortality. The hypothesis that the EuroSCORE II is better suited for the selection of candidates to Valve-in-Valve implantation is worth of further multi-institutional investigations on the basis of our preliminary findings and due to the expanding role of transcatheter techniques
Curcumin targets fibroblast-tumor cell interactions in oral squamous cell carcinoma.

Co-culture of periodontal ligament fibroblasts (PDLs) and SCC-25 oral squamous carcinoma cells (OSCC) results in conversion of PDLs into carcinoma-associated fibroblasts (CAFs) and induces epithelial-to mesenchymal transition (EMT) of OSCC tumor cells. We hypothesized that Curcumin targets this dynamic mutual interaction between CAFs and tumor cells. Normal and 2muM Curcumin-treated co-culture were performed for 4 days, followed by analysis of tumor cell invasivity, mRNA/protein expression of EMT-markers and mediators, activity measure of matrix metalloproteinase 9 (MMP-9), and western blot analysis of signal transduction in tumor cells and fibroblasts. In Curcumin-treated co-culture, in tumor cells, the levels of nuclear factor kappaB (NFkappaBalpha) and early response kinase (ERK)-decreased, in fibroblasts, integrin alphav protein synthesis decreased compared to corresponding cells in normal co-culture. The signal modulatory changes induced by Curcumin caused decreased release of EMT-mediators in CAFs and reversal of EMT in tumor cells, which was associated with decreased invasion. These data confirm the palliative potential of Curcumin in clinical application
Mental flexibility impairment in drivers with early Alzheimer’s disease: A simulator-based study

After memory impairment, one of the most common troubles of early Alzheimer’s disease (AD) is the impairment of executive functioning. However, it can have major consequences on daily life, notably on the driving activity. The present study focused on one important executive function involved in driving: mental flexibility; and considered how this impairment can affect driving. Ten patients with early AD were matched with 29 healthy older drivers. All participants were given an evaluation of mental flexibility through neuropsychological tests and an experimental test developed on a static driving simulator. The experiment was divided in two conditions; one without mental flexibility and another condition with a mental flexibility demand. AD patients showed impairments in the neuropsychological tests evaluating mental flexibility. These deficits are linked to the deficits they showed in the driving simulator flexibility tests. This study contributes to the understanding of mental flexibility mechanisms and on their role in driving activity. It also confirms that the driving simulator is a suitable tool to explore cognitive disorders and driving ability
Very high-energy γ -ray observations of novae and dwarf novae with the MAGIC telescopes

Context. In the last five years the Fermi Large Area Telescope (LAT) instrument detected GeV γ-ray emission from five novae. The GeV emission can be interpreted in terms of an inverse Compton process of electrons accelerated in a shock. In this case it is expected that protons in the same conditions can be accelerated to much higher energies. Consequently they may produce a second component in the γ-ray spectrum at TeV energies. \ud
Aims: We aim to explore the very high-energy domain to search for γ-ray emission above 50 GeV and to shed light on the acceleration process of leptons and hadrons in nova explosions. \ud
Methods: We have performed observations, with the MAGIC telescopes of the classical nova V339 Del shortly after the 2013 outburst; optical and subsequent GeV γ-ray detections triggered the MAGIC observations. We also briefly report on VHE observations of the symbiotic nova YY Her and the dwarf nova ASASSN-13ax. We complement the TeV MAGIC observations with the analysis of contemporaneous Fermi-LAT data of the sources. The TeV and GeV observations are compared in order to evaluate the acceleration parameters for leptons and hadrons. \ud
Results: No significant TeV emission was found from the studied sources. We computed upper limits on the spectrum and night-by-night flux. The combined GeV and TeV observations of V339 Del limit the ratio of proton to electron luminosities to Lp ≲ 0.15 Le
Factorization in a torus and Riemann-Hilbert problems

Article in press, corrected proofA new concept of meromorphic $\Sigma$-factorization, for H\"{o}lder continuous functions defined on a contour $\Gamma$ that is the pullback of $\dot{\mathbb{R}}$ (or the unit circle) in a Riemann surface $\Sigma$ of genus 1, is introduced and studied, and its relations with holomorphic $\Sigma$-factorization are discussed. It is applied to study and solve some scalar Riemann-Hilbert problems in $\Sigma$ and vectorial Riemann-Hilbert problems in $\mathbb{C}$, including Wiener-Hopf matrix factorization, as well as to study some properties of a class of Toeplitz operators with $2 \times 2$ matrix symbols.Fundação para a Ciência e a Tecnologia (FCT
Polysaccharide-based nanostructured multilayers with distinct sulfated and aminated composition to improve cells response and biomineralization

Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013)In vitro cell expansion, differentiation for further cell transplantation
and biomaterials-cell fundamental assays are still performed more often
on inert 2D surfaces than on 3D culture. 3D systems do not allow an
easy cell monitoring and may demand higher cell density, being more
costly and time consuming. Inert surfaces (polystyrene, biodegradable
thermoplastics or metals) neither resemble the extracellular matrix
(ECM) milieu nor trigger intercellular signaling. Several studies are
focused on surface modification and on the correlation of the surface
properties such as roughness, wettability and chemistry with cell
behavior with regard to the effects on cell adhesion, morphology, proliferation,
survival and differentiation.1,2 Proteins, hormones, small peptides,
cytokines, inorganic molecules, sulfated and non-polysaccharides
(PS) compose the natural 3D ECM milieu. PS vary on the sulfur content,
sulfonic group (Sg) position and on base units. Sulfonated and
sulfated PS have intrinsic very high affinity towards growth factors and
positively charged molecules through the functional groups turning the
combination of themvery bioactive hybrids mats. Current surface modification
models make the transposition to 3D systems complicate.
Layer-by-Layer (LbL) assembling is a versatile technique to coat any
2D/3D structure with polyelectrolytes (PE) which coatings properties
can be modelled and controlled. Herein, LbL was employed to develop
2D models to verify the ability of sulfated and aminated coatings to
improve cell function using PS form marine origin: chitosan (Chi) and
carrageenans (Cars). Chi and Cars have equivalent functional groups to
the ones that are naturally found in the ECM: -NH2, -OSO3H, and -OH.
CHI and j, ι and k Car (1, 2 and 3 Sg, respectively) nanocoatings were
assessed by QCM-D, modelled by the Voigt-model, and characterized
by AFM, SEM and XPS3. The properties of the multilayers can be controlled
as well the relative amount of the positive versus the negative
PE. Moreover, the effects on biomineralization of SaOs-2 cell line were
investigated. The coatings, specially ι Car coatings, increased significantly
alkaline phosphatase activity and biomineralization of SaOs-2
cell line. The results indicated that the coatings do not only attract
medium ions but also enhance osteogenic cell function. These models
are interesting to study cell-materials interactions where surfaces culture
with increased biofunctionality can be developed
Measurement of D-meson production versus multiplicity in p-Pb collisions at sNN−−−√=5.02 TeV

The measurement of prompt D-meson production as a function of multiplicity in p-Pb collisions at sNN−−−√=5.02 TeV with the ALICE detector at the LHC is reported. D0, D+ and D∗+ mesons are reconstructed via their hadronic decay channels in the centre-of-mass rapidity range −0.96 < ycms< 0.04 and transverse momentum interval 1<pT<24 GeV/c. The multiplicity dependence of D-meson production is examined by either comparing yields in p-Pb collisions in different event classes, selected based on the multiplicity of produced particles or zero-degree energy, with those in pp collisions, scaled by the number of binary nucleon-nucleon collisions (nuclear modification factor); as well as by evaluating the per-event yields in p-Pb collisions in different multiplicity intervals normalised to the multiplicity-integrated ones (relative yields). The nuclear modification factors for D0, D+ and D∗+ are consistent with one another. The D-meson nuclear modification factors as a function of the zero-degree energy are consistent with unity within uncertainties in the measured pT regions and event classes. The relative D-meson yields, calculated in various pT intervals, increase as a function of the charged-particle multiplicity. The results are compared with the equivalent pp measurements at s√=7 TeV as well as with EPOS 3 calculations