pinecone/core-2020-05-10-deduplication huggingface dataset:
The TANAMI Multiwavelength Program: Dynamic SEDs of Southern Blazars

Simultaneous broadband spectral and temporal studies of blazars are an
important tool for investigating active galactic nuclei (AGN) jet physics. We
study the spectral evolution between quiescent and flaring periods of 22
radio-loud AGN through multi-epoch, quasi-simultaneous broadband spectra. For
many of these sources these are the first broadband studies. We use a Bayesian
block analysis of \Fermi/LAT light curves in order to determine time ranges of
constant flux for constructing quasi-simultaneous SEDs. The shapes of the
resulting 81 SEDs are described by two logarithmic parabolas and a blackbody
spectrum where needed. For low states the peak frequencies and luminosities
agree well with the blazar sequence, higher luminosity implying lower peak
frequencies. This is not true for sources in a high state. The $\gamma$-ray
photon index in Fermi/LAT correlates with the synchrotron peak frequency in low
and intermediate states. No correlation is present in high states. The black
hole mass cannot be determined from the SEDs. Surprisingly, the thermal excess
often found in FSRQs at optical/UV wavelengths can be described by blackbody
emission and not an accretion disk spectrum. The "harder-when-brighter" trend,
typically seen in X-ray spectra of flaring blazars, is visible in the blazar
sequence. Our results for low and intermediate states, as well as the Compton
dominance, are in agreement with previous results. Black hole mass estimates
using the parameters from Bonchi (2013) are in agreement with some of the more
direct measurements. For two sources, estimates disagree by more than four
orders of magnitude, possibly due to boosting effects. The shapes of the
thermal excess seen predominantly in flat spectrum radio quasars are
inconsistent with a direct accretion disk origin.Comment: accepted for publication in A&
CD45RO+ Memory T Lymphocytes – a Candidate Marker for TNM-Immunoscore in Squamous Non-Small Cell Lung Cancer

Published version also available at <a href=http://dx.doi.org/10.1016/j.neo.2015.11.004>http://dx.doi.org/10.1016/j.neo.2015.11.004</a>Tumor-infiltrating lymphocytes (TILs) are vital in limiting cancer progression and may supplement the TNM classification.
CD45RO+ memory TILs show major prognostic impact in various malignancies but have not been extensively explored in
non–small cell lung cancer (NSCLC). In this study, we aimed to evaluate their potential in a NSCLC TNM-Immunoscore.
Tissue microarrays were constructed from tumor tissue samples from two cohorts including in total 536 patients
(University Hospital of North Norway, n = 285; Nordland Hospital, n = 251) with primary resected stage I to IIIA NSCLC.
The density of CD45RO+ and CD8+ TILs in tumor epithelial and stromal compartments of the tumors was evaluated by
immunohistochemistry. In univariate analyses, intraepithelial CD45RO+ TIL density (T-CD45RO) was a significant
prognostic factor for disease-specific survival (P = .007), limited to the squamous cell carcinoma (SCC) histology subgroup
(P b .001), where it was significant in both cohorts (University Hospital of North Norway, P = .003; Nordland Hospital, P =
.022). Combining T-CD45RO and stromal CD8+ TIL density (S-CD8) increased the prognostic impact in SCC (P b .001) and
showed a significant impact within all pathological stages (I, P = .025; II, P b .001; III, P = .001). In the multivariate analysis,
T-CD45RO was an independent positive prognostic factor for SCC (hazard ratio 2.65, 95% confidence interval 1.64-4.28,
P b .001), and in combination with S-CD8, the prognostic impact increased vastly (high + high versus low + low: hazard
ratio 6.50, 95% confidence interval 3.54-11.91, P b .001). In conclusion, T-CD45RO was an independent prognostic factor
for SCC NSCLC. When combined with S-CD8, the prognostic impact increased and was significant within each
pathological stage. We propose CD45RO as a candidate marker for TNM-Immunoscore in SCC NSCLC
Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels.

International audiencePhysiologically relevant hepatic cell culture models must be based on three-dimensional (3D) culture of human cells. However, liver cells are generally cultured in two-dimensional (2D) format that deviates from the normal in vivo morphology. We generated 3D culture environment for HepaRG liver progenitor cells using wood-derived nanofibrillar cellulose (NFC) and hyaluronan-gelatin (HG) hydrogels. Culture of undifferentiated HepaRG cells in NFC and HG hydrogels induced formation of 3D multicellular spheroids with apicobasal polarity and functional bile canaliculi-like structures, structural hallmarks of the liver tissue. Furthermore, hepatobiliary drug transporters, MRP2 and MDR1, were localized on the canalicular membranes of the spheroids and vectorial transport of fluorescent probes towards the biliary compartment was demonstrated. Cell culture in 3D hydrogel supported the mRNA expression of hepatocyte markers (albumin and CYP3A4), and metabolic activity of CYP3A4 in the HepaRG cell cultures. On the contrary, the 3D hydrogel cultures with pre-differentiated HepaRG cells showed decreasing expression of albumin and CYP3A4 transcripts as well as CYP3A4 activity. It is concluded that NFC and HG hydrogels expedite the hepatic differentiation of HepaRG liver progenitor cells better than the standard 2D culture environment. This was shown as improved cell morphology, expression and localization of hepatic markers, metabolic activity and vectorial transport. The NFC and HG hydrogels are promising materials for hepatic cell culture and tissue engineering
The second Sandia Fracture Challenge : predictions of ductile failure under quasi-static and moderate-rate dynamic loading

International audienceDuctile failure of structural metals is relevant to a wide range of engineering scenarios. Computational methods are employed to anticipate the critical conditions of failure, yet they sometimes provide inaccurate and misleading predictions. Challenge scenarios , such as the one presented in the current work, provide an opportunity to assess the blind, quantitative predictive ability of simulation methods against a previously unseen failure problem. Rather than evaluate the predictions of a single simulation approach, the Sandia Fracture Challenge relies on numerous volunteer teams with expertise in computational mechanics to apply a broad range of computational methods, numerical algorithms, and constitutive models to the challenge. This exercise is intended to evaluate the state of health of technologies available for failure prediction. In the first Sandia Fracture Challenge, a wide range of issues were raised in ductile failure modeling, including a lack of consistency in failure models, the importance of shear calibration data, and difficulties in quantifying the uncertainty of prediction [see Boyce et al. (Int J Fract 186:5–68, 2014) for details of these observations]. This second Sandia Fracture Challenge investigated the ductile rupture of a Ti–6Al–4V sheet under both quasi-static and modest-rate dynamic loading (failure in ∼0.1 s). Like the previous challenge, the sheet had an unusual arrangement of notches and holes that added geometric complexity and fostered a competition between tensile-and shear-dominated failure modes. The teams were asked to predict the fracture path and quantitative far-field failure metrics such as the peak force and displacement to cause crack initiation. Fourteen teams contributed blind predictions, and the experimental outcomes were quantified in three independent test labs. Additional shortcomings were revealed in this second challenge such as inconsistency in the application of appropriate boundary conditions, need for a thermomechanical treatment of the heat generation in the dynamic loading condition, and further difficulties in model calibration based on limited real-world engineering data. As with the prior challenge, this work not only documents the 'state-of-the-art' in computational failure prediction of ductile tearing scenarios , but also provides a detailed dataset for non-blind assessment of alternative methods
Non-uniform painless decompositions for anisotropic Besov and Triebel-Lizorkin spaces

In this article we construct aﬃne systems that provide a simultaneous atomic decomposition for a wide class of functional spaces including the Lebesgue spaces Lp(Rd)  1 < p < +∞. The novelty and diﬃculty of this
construction is that we allow for non-lattice translations.
We prove that for an arbitrary expansive matrix A and any set Λ - satisfying a certain spreadness condition but otherwise irregular- there exists a smooth window whose translations along the elements of Λ and dilations by powers  of A provide an atomic decomposition for the whole range of the anisotropic Triebel-Lizorkin spaces. The generating window can be either chosen to be bandlimited or to have compact support.
To derive these results we start with a known general “painless” construction that has recently appeared in the literature. We show that this construction extends to Besov and Triebel-Lizorkin spaces by providing adequate dual systems.Fil: Cabrelli, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigaciones Matemáticas "Luis A. Santalo"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; ArgentinaFil: Molter, Ursula Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigaciones Matemáticas "Luis A. Santalo"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; ArgentinaFil: Romero, Jose Luis Fernando. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigaciones Matemáticas "Luis A. Santalo"; Argentin
Dendrimer-based nanoparticles in tissue engineering and regenerative medicine approaches

Dendrimeric macromolecules are synthetic and spherical systems that
have been attracting great deal of attention as nanocarriers for intracellular
drug delivery (DDS) [1]. These possess several advantages as
nanocarriers, as it possibly incorporating smart functionalities such as
targetability and stimuli-responsive drug release. Our group has been
proposing the use of dexamethasone (Dex)-loaded carboxymethylchitosan/
polyamidoamine dendrimer nanoparticles (CMCht/PAMAM
NPs) [2,3] for controlling the differentiation of stem cells towards the
osteogenic lineage. In this work, the biocompatibility of the Dex-loaded
CMCht/PAMAM NPs were investigated, in vitro and in vivo. CMCht/PAMAM
NPs were produced as described by Oliveira et al. [4]. Dexamethasone
(Dex) was loaded into the NPs by means of using a precipitation
route. Dex-loaded NPs were chemically bound to fluorescein isothiocyanate
(FITC) for styding their intracellular fate. The cellular uptake of
NPs was investigated using different cell types namely rat bone marrow
stromal cells (RBMSCs) and Human Osteosarcoma cell line (SaOS-2),
for times up to 14 days of culturing. The internalization of the FITClabelled
and Dex-loaded CMCht/PAMAM dendrimer NPs waere investigated
using fluorescence microscopy and flow cytometry (FACS) analyses.
FITC-labelled NPs (1 lg/g and 10 lg/g) were injected
intraveneously on Wistar rats and its biodistribution in different organs
was evaluated up to 72 h. Results have revealed that Dex-loaded
CMCht/PAMAM dendrimer NPs are non-cytotoxic, in vitro and in vivo.
The in vivo studies also revealed that CMCht/PAMAM dendrimer NPs
are stable in circulation. The histological study has shown that NP’s are
uptaken by cells from different tissues/organs namely, brain, liver, kidney
and lung. This study has revealed that the dexamethasone-loaded
CMCht/PAMAM dendrimer nanoparticles are non-toxic and demonstrated
a great ability for being uptaken by different cell types. Moreover,
we have demonstrated that the dexamethasone-loaded CMCht/
PAMAM dendrimer nanoparticles are able to control stem cells osteogenic
differentiation. As a final conclusion, the developed nanocarriers
are advantageous as intracellular nanocarrier tools for preprogramming
the stem cells fate ex vivo. The developed dexamethasone-loaded
CMCht/PAMAM dendrimer nanoparticles showed great promise for
application in bone tissue engineering strategies as it allowed us to produce
de novo bone tissue in vivo
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector

The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1 fb−1 of proton-proton collision data at s√ = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t¯ →tχ¯01 or t¯ →bχ¯±1 →bW(∗)χ¯01 , where χ¯01 (χ¯±1) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t¯ →tχ¯01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ¯01 masses below 30 GeV. For a branching fraction of 50% to either t¯ →tχ¯01 or t¯ →bχ¯±1 , and assuming the χ¯±1 mass to be twice the χ¯01 mass, top squark masses in the range 250–550 GeV are excluded for χ¯01 masses below 60 GeV.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPE SP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Un ion; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT and NSRF, Greece; ISF, MINERVA, GIF, I-CORE and Benozi yo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW and NCN, Poland; GRICES and FCT, Portuga l; MNE/IFA, Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MIZ. S, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN and the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (U.K.) and BNL (U.S.A.) and in the Tier-2 facilities worldwide
Measurement of exclusive γγ→ℓ+ℓ− production in proton--proton collisions at s√=7 TeV with the ATLAS detector

This Letter reports a measurement of the exclusive γγ→ℓ+ℓ−(ℓ=e,μ) cross-section in proton--proton collisions at a centre-of-mass energy of 7 TeV by the ATLAS experiment at the LHC, based on an integrated luminosity of 4.6 fb−1. For the electron or muon pairs satisfying exclusive selection criteria, a fit to the dilepton acoplanarity distribution is used to extract the fiducial cross-sections. The cross-section in the electron channel is determined to be σexcl.γγ→e+e−=0.428±0.035(stat.)±0.018(syst.) pb for a phase-space region with invariant mass of the electron pairs greater than 24 GeV, in which both electrons have transverse momentum pT>12 GeV and pseudorapidity |η|<2.4. For muon pairs with invariant mass greater than 20 GeV, muon transverse momentum pT>10 GeV and pseudorapidity |η|<2.4, the cross-section is determined to be σexcl.γγ→μ+μ−=0.628±0.032(stat.)±0.021(syst.) pb. When proton absorptive effects due to the finite size of the proton are taken into account in the theory calculation, the measured cross-sections are found to be consistent with the theory prediction.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT and NSRF, Greece; RGC, Hong Kong SAR, China; ISF, MINERVA, GIF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW and NCN, Poland; GRICES and FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America
Measurement of the dependence of transverse energy production at large pseudorapidity on the hard-scattering kinematics of proton–proton collisions at √s=2.76 TeV with ATLAS

The relationship between jet production in the central region and the underlying-event activity in a pseudorapidity-separated region is studied in 4.0 pb−1 of View the MathML sources=2.76 TeVpp collision data recorded with the ATLAS detector at the LHC. The underlying event is characterised through measurements of the average value of the sum of the transverse energy at large pseudorapidity downstream of one of the protons, which are reported here as a function of hard-scattering kinematic variables. The hard scattering is characterised by the average transverse momentum and pseudorapidity of the two highest transverse momentum jets in the event. The dijet kinematics are used to estimate, on an event-by-event basis, the scaled longitudinal momenta of the hard-scattered partons in the target and projectile beam-protons moving toward and away from the region measuring transverse energy, respectively. Transverse energy production at large pseudorapidity is observed to decrease with a linear dependence on the longitudinal momentum fraction in the target proton and to depend only weakly on that in the projectile proton. The results are compared to the predictions of various Monte Carlo event generators, which qualitatively reproduce the trends observed in data but generally underpredict the overall level of transverse energy at forward pseudorapidity
Search for microscopic black holes in pp collisions at √s=8 TeV

Journal of High Energy Physics 2013.7 (2013): 178 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMA search for microscopic black holes and string balls is presented, based on a data sample of pp collisions at √s=8 TeV recorded by the CMS experiment at the Large Hadron Collider and corresponding to an integrated luminosity of 12 fb-1. No excess of events with energetic multiparticle final states, typical of black hole production or of similar new physics processes, is observed. Given the agreement of the observations with the expected standard model background, which is dominated by QCD multijet production, 95% confidence level limits are set on the production of semiclassical or quantum black holes, or of string balls, corresponding to the exclusions of masses below 4.3 to 6.2 TeV, depending on model assumptions. In addition, model-independent limits are set on new physics processes resulting in energetic multiparticle final state
Maritime education in a transdisciplinary world : the case of Hong Kong

Some universities have their maritime education situated in faculty of engineering while few are included in faculty of business. Emphasises are apparently different for those in faculty of engineering from those in faculty of business. The maritime business curriculum has to fulfill the requirements of accreditation of different international organizations e.g. STCW95 and AACSB. This paper is to study the curriculum developed in maritime education at the Department of Logistics and Maritime Studies of The Hong Kong Polytechnic University and it is not easy to fulfill the requirements of different international organizations. The quality of maritime business curriculum offered by educational institutions is critical in ensuring the quality of future shipping executives for the shipping community in Hong Kong.Department of Logistics and Maritime StudiesAuthor name used in this publication: Jim Mi NgAuthor name used in this publication: Tsz Leung Yip2008-2009 > Academic research: refereed > Publication in refereed journalpublished_fina
Synthesis, Spectroscopic and Crystal Structure Analysis of 2-(4-Fluorobenzyl)-6-(4-Methoxyphenyl)Imidazo[2,1-B][1,3,4]Thiadiazole and its Morpholinomethyl Derivative

The preparation of 2-(4-fluorobenzyl)-6-(4-methoxyphenyl)-5-morpholin-1-ylmethyl imidazo[2,1-b][1,3,4]thiadiazole via the intermediate 2-(4-fluorobenzyl)-6-(4-methoxyphenyl)Imidazo[2,1-b][1,3,4] thiadiazole is described. Elemental analysis, IR spectrum, 1H NMR and X-ray crystal structure analyses were carried out to determine the compositions and molecular structures of the two compounds. The crystal packing exhibits intermolecular C–H?O, C–H?N, C–H?F and π–π stacking interactions leading to the formation of the supramolecular network
Stellar kinematics across the Hubble sequence in the CALIFA survey:
  General properties and aperture corrections

We present the stellar kinematic maps of a large sample of galaxies from the
integral-field spectroscopic survey CALIFA. The sample comprises 300 galaxies
displaying a wide range of morphologies across the Hubble sequence, from
ellipticals to late-type spirals. This dataset allows us to homogeneously
extract stellar kinematics up to several effective radii. In this paper, we
describe the level of completeness of this subset of galaxies with respect to
the full CALIFA sample, as well as the virtues and limitations of the kinematic
extraction compared to other well-known integral-field surveys. In addition, we
provide averaged integrated velocity dispersion radial profiles for different
galaxy types, which are particularly useful to apply aperture corrections for
single aperture measurements or poorly resolved stellar kinematics of
high-redshift sources. The work presented in this paper sets the basis for the
study of more general properties of galaxies that will be explored in
subsequent papers of the survey.Comment: 52 pages, 44 figures, A&A accepted. FITS tables with the stellar
  kinematic results are available at:
  http://www.caha.es/CALIFA/public_html/?q=content/science-dataproducts A
  full-resolution version of the manuscript is also available on the same
  webpag