pinecone/core-2020-05-10-deduplication huggingface dataset:
1-octanol, a self-inhibitor of spore germination in Penicillium camemberti

International audiencePenicillium camemberti is a technologically relevant fungus used to manufacture mould-ripened cheeses. This fungal species produces many volatile organic compounds (VOCs) including ammonia, methyl-ketones, alcohols and esters. Although it is now well known that VOCs can act as signaling molecules, nothing is known about their involvement in P. camemberti lifecycle. In this study, spore germination was shown to be self-regulated by quorum sensing in P. camemberti. This phenomenon, also called the "crowding effect", is population-dependent (i.e. observed at high population densities). After determining the volatile nature of the compounds involved in this process, 1-octanol was identified as the main compound produced at high-spore density using GC-MS. Its inhibitory effect was confirmed in vitro and 3 mM 1-octanol totally inhibited spore germination while 100 μM only transiently inhibited spore germination. This is the first time that self-inhibition of spore germination is demonstrated in P. camemberti. The obtained results provide interesting perspectives for better control of mould-ripened cheese processe
Field effect transistor with integrated microfluidic channel as pH sensor

International audienceThis paper presents an original design of chemical sensors with an integrated microfluidic channel. Targeted applications are pH-meters devices. The integration of the microfluidic channel allows decreasing the volume required for each measurement. The sensing part of the device consists of a field effect transistor (FET) with a suspended gate directly performed above the fluidic channel. Chemicals under test are driven through the sensing area between the electrical channel of the FET and the suspended gate. By this way products that flow in the microfluidic channel directly module the concentration of charges inside the transistor's gap and thus induce changes in the transfer characteristic. This paper describes the fabrication process and the technological choices for materials. Electrical tests, performed in air and in liquid, have shown a good behavior of the transistor, linked to a good mechanical sustain of the fluidic channel. The system is able to detect transition between air and liquid media. Moreover, it has shown a high sensitivity (about 300 mV/pH) to pH measurements
A polygon soup representation for multiview coding

WOSInternational audienceThis paper presents a polygon soup representation for multiview data. Starting from a sequence of multi-view video plus depth (MVD) data, the proposed quad-based representation takes into account, in a unified manner, different issues such as compactness, compression, and intermediate view synthesis. The representation is extracted from MVD data in two steps. First, a set of 3D quads is extracted thanks to quadtree decomposition performed on depth maps. Second, a selective limination of the quads is performed in order to reduce inter-view redundancies and thus provide a compact representation. Moreover, the proposed methodology for extracting the representation allows to reduce ghosting artifacts. Finally, an adapted compression technique is proposed that limits coding artifacts. The results presented on two real sequences show that the proposed representation provides a good trade-off between rendering quality and data compactness
Photoinduced phenomena and structural analysis associated with the spin-state switching in the [FeII(DPEA)(NCS)2] complex

International audienceOut-of-equilibrium photoinduced switching from the low-spin to the high-spin state has been investigated on the iron(II) complex [Fe(II)(DPEA)(NCS)2] by both optical reflectivity and magnetic measurements under continuous light irradiation at low temperature. The photoinduced HS state can be observed up to 47 K and the relaxation process has been followed. Structural changes of both the temperature- and the photoinduced spin-state switching have been analyzed in detail by x-ray diffraction indicating no change of symmetry. Short intermolecular contacts and intramolecular deformations associated with the change of molecular spin state have been quantified. Actually a crossover behavior is observed at thermal equilibrium with however a quasiabrupt shape indicating significant cooperative effects. These aspects are compared between the temperature- and photoinduced spin crossovers
Industry-oriented Performance Measures for Design of Robot Calibration Experiment

The paper focuses on the accuracy improvement of geometric and elasto-static calibration of industrial robots. It proposes industry-oriented performance measures for the calibration experiment design. They are based on the concept of manipulator test-pose and referred to the end-effector location accuracy after application of the error compensation algorithm, which implements the identified parameters. This approach allows the users to define optimal measurement configurations for robot calibration for given work piece location and machining forces/torques. These performance measures are suitable for comparing the calibration plans for both simple and complex trajectories to be performed. The advantages of the developed techniques are illustrated by an example that deals with machining using robotic manipulator
Future changes in precipitation and impacts on extreme streamflow over Amazonian sub-basins

International audienceBecause of climate change, much attention is drawn to the Amazon River basin, whose hydrology has already been strongly affected by extreme events during the past 20 years. Hydrological annual extreme variations (i.e. low/high flows) associated with precipitation (and evapotranspiration) changes are investigated over the Amazon River sub-basins using the land surface model ORCHIDEE and a multimodel approach. Climate change scenarios from up to eight AR4 Global Climate Models based on three emission scenarios were used to build future hydrological projections in the region, for two periods of the 21st century. For the middle of the century under the SRESA1B scenario, no change is found in high flow on the main stem of the Amazon River (Óbidos station), but a systematic discharge decrease is simulated during the recession period, leading to a 10% low-flow decrease. Contrasting discharge variations are pointed out depending on the location in the basin. In the western upper part of the basin, which undergoes an annual persistent increase in precipitation, high flow shows a 7% relative increase for the middle of the 21st century and the signal is enhanced for the end of the century (12%). By contrast, simulated precipitation decreases during the dry seasons over the southern, eastern and northern parts of the basin lead to significant low-flow decrease at several stations, especially in the Xingu River, where it reaches -50%, associated with a 9% reduction in the runoff coefficient. A 18% high-flow decrease is also found in this river. In the north, the low-flow decrease becomes higher toward the east: a 55% significant decrease in the eastern Branco River is associated with a 13% reduction in the runoff coefficient. The estimation of the streamflow elasticity to precipitation indicates that southern sub-basins (except for the mountainous Beni River), that have low runoff coefficients, will become more responsive to precipitation change (with a 5 to near 35% increase in elasticity) than the western sub-basins, experiencing high runoff coefficient and no change in streamflow elasticity to precipitation. These projections raise important issues for populations living near the rivers whose activity is regulated by the present annual cycle of waters. The question of their adaptability has already arisen
A CD31-derived peptide prevents angiotensin II-induced atherosclerosis progression and aneurysm formation.

International audienceAIMS: The loss of the inhibitory receptor CD31 on peripheral T lymphocytes is associated with the incidence of atherosclerotic complications such as abdominal aortic aneurysms (AAA) in patients and plaque thrombosis in mice. However, we have recently discovered that a small fragment of extracellular CD31 remains expressed on the surface of the apparently 'CD31-negative' T-cells and that it is possible to restore the CD31-mediated T-cell inhibition in vivo by using a synthetic CD31-derived peptide. Here, we wanted to evaluate the therapeutic potential of the peptide in an experimental model of accelerated atherosclerosis and AAA formation. METHODS AND RESULTS: The effect of the murine CD31-derived peptide (aa 551-574, 1.5 mg/kg/day, sc) was evaluated on the extent of atherosclerotic plaques and the incidence of AAA in 28-week-old apolipoprotein E knockout mice (male, n ≥ 8/group) submitted to chronic angiotensin II infusion. The therapeutic mechanisms of the peptide were assessed by evaluating its effect on immune cell functions in vivo and in vitro. The prevalence of angiotensin II-induced AAA correlated with the loss of extracellular CD31 on T-cells. CD31 peptide treatment reduced both aneurysm formation and plaque size (P < 0.05 vs. control). Protection was associated with reduced perivascular leucocyte infiltration and T-cell activation in vivo. Functional in vitro studies showed that the peptide is able to suppress both T-cell and macrophage activation. CONCLUSION: CD31 peptides could represent a new class of drugs intended to prevent the inflammatory cell processes, such as those underlying progression of atherosclerosis and development of AAA
Sideroblastic anemia: molecular analysis of <i>ALAS2</i> gene in a series of 29 probands and functional studies of ten missense mutations.

International audienceX-linked Sideroblastic Anemia (XLSA) is the most common genetic form of sideroblastic anemia, a heterogeneous group of disorders characterized by iron deposits in the mitochondria of erythroid precursors. XLSA is due to mutations in the erythroid-specific 5-aminolevulinate synthase (<i>ALAS2</i>) gene. Thirteen different <i>ALAS2</i> mutations were identified in 16 out of 29 probands with sideroblastic anemia. One third of the patients were females with a highly skewed X-chromosome inactivation. The identification of seven novel mutations in the <i>ALAS2</i> gene, six missense mutations, and one deletion in the proximal promoter extends the allelic heterogeneity of XSLA. Most of the missense mutations were predicted to be deleterious and ten of them, without any published functional characterization, were expressed in <i>E. coli</i>. ALAS2 activities were assayed <i>in vitro</i>. Five missense mutations resulted in decreased enzymatic activity under standard conditions, and two other mutated proteins had decreased activity when assayed in the absence of exogenous pyridoxal phosphate and increased thermosensitivity. Although most amino-acid substitutions result in a clearly decreased enzymatic activity <i>in vitro</i>, a few mutations have a more subtle effect on the protein that is only revealed by <i>in vitro</i> tests under specific conditions
Highly efficient multilayer organic pure-blue-light emitting diodes with substituted carbazoles compounds in the emitting layer.

Bright blue organic light-emitting diodes (OLEDs) based on 1,4,5,8,N-pentamethylcarbazole (PMC) and on dimer of N-ethylcarbazole (N,N'-diethyl-3,3'-bicarbazyl) (DEC) as emitting layers or as dopants in a 4,4'-bis(2,2'-diphenylvinyl)-1,1'-biphenyl (DPVBi) matrix are described. Pure blue-light with the C.I.E. coordinates x = 0.153 y = 0.100, electroluminescence efficiency eta EL of 0.4 cd/A, external quantum efficiency eta ext. of 0.6% and luminance L of 236 cd/m2 (at 60 mA/cm2) were obtained with PMC as an emitter and the 2,9-dimethyl-4,7-diphenyl-1,10-phenantroline (BCP) as a hole-blocking material in five-layer emitting devices. The highest efficiencies eta EL. of 4.7 cd/A, and eta ext = 3.3% were obtained with a four-layer structure and a DPVBi DEC-doped active layer (CIE coordinates x = 0.158, y=0.169, λpeak = 456 nm). The eta ext. value is one the highest reported at this wavelength for blue OLEDs and is related to an internal quantum efficiency up to 20
Monitoring the solar UV irradiance spectrum from the observation of a few passbands

International audienceThe solar irradiance in the UV is a key ingredient in space weather applications; however, because of the lack of continuous and long-term observations, various indices are still used today as surrogates for the solar spectral irradiance. Aims. As an alternative to current spectrometers we use a few radiometers with properly chosen passbands and reconstruct the solar spectral irradiance from their outputs. The feasibility of such a reconstruction is justified by the high redundancy in the spectral variability. Methods. Using a multivariate statistical approach, we first compared six years of daily-averaged UV spectra and a selection of passbands (from existing radiometers) and solar indices. This leads to a strategy for defining those passbands that are most appropriate for reconstructing the spectrum. Results. With four passdbands chosen from already existing instruments, we reconstruct the UV spectrum with a relative error of about 20%. Better performance is achieved with a combination of passbands than with a combination of indices
Recursion based parallelization of exact dense linear algebra routines for Gaussian elimination

International audienceWe present block algorithms and their implementation for the parallelization of sub-cubic Gaussian elimination on shared memory architectures.Contrarily to the classical cubic algorithms in parallel numerical linear algebra, we focus here on recursive algorithms and coarse grain parallelization.Indeed, sub-cubic matrix arithmetic can only be achieved through recursive algorithms making coarse grain block algorithms perform more efficiently than fine grain ones. This work is motivated by the design and implementation of dense linear algebraover a finite field, where fast matrix multiplication is used extensively and where costly modular reductions also advocate for coarse grain block decomposition. We incrementally build efficient kernels, for matrix multiplication first, then triangular system solving, on top of which a recursive PLUQ decomposition algorithm is built. We study the parallelization of these kernels using several algorithmic variants: either iterative or recursive and using different splitting strategies. Experiments show that recursive adaptive methods for matrix multiplication, hybrid recursive-iterative methods for triangular system solve and tile recursive versions of the PLUQ decomposition, together with various data mapping policies, provide the best performance on a 32 cores NUMA architecture. Overall, we show that the overhead of modular reductions is more than compensated by the fast linear algebra algorithms and that exact dense linear algebra matches the performance of full rank reference numerical software even in the presence of rank deficiencies
Large deviations estimates for the multiscale analysis of heart rate variability

International audienceIn the realm of multiscale signal analysis, multifractal analysis provides with a natural and rich framework to measure the roughness of a time series. As such, it has drawn special attention of both mathematicians and practitioners, and led them to characterize relevant physiological factors impacting the heart rate variability. Notwithstanding these considerable progresses, multifractal analysis almost exclusively developed around the concept of Legendre singularity spectrum, for which efficient and elaborate estimators exist, but which are structurally blind to subtle features like non-concavity or, to a certain extent, non scaling of the distributions. Large deviations theory allows bypassing these limitations but it is only very recently that performing estimators were proposed to reliably compute the corresponding large deviations singularity spectrum. In this article, we illustrate the relevance of this approach, on both theoretical objects and on human heart rate signals from the Physionet public database. As conjectured, we verify that large deviations principles reveal significant information that otherwise remains hidden with classical approaches, and which can be reminiscent of some physiological characteristics. In particular we quantify the presence/absence of scale invariance of RR signals
Allee effect promotes diversity in traveling waves of colonization

International audienceMost mathematical studies on expanding populations have fo-cused on the rate of range expansion of a population. However, the genetic consequences of population expansion remain an under-studied body of theory. Describing an expanding population as a traveling wave solution derived from a classical reaction-diffusion model, we analyze the spatio-temporal evolution of its genetic structure. We show that the presence of an Allee effect (i.e., a lower per capita growth rate at low densities) drastically modifies genetic diversity, both in the colonization front and behind it. With an Allee effect (i.e., pushed colonization waves), all of the genetic diversity of a population is conserved in the colonization front. In the absence of an Allee effect (i.e., pulled waves), only the furthest forward members of the initial population persist in the coloniza-tion front, indicating a strong erosion of the diversity in this population. These results counteract commonly held notions that the Allee effect generally has adverse consequences. Our study contributes new knowledge to the surfing phenomenon in continuous models without random genetic drift. It also provides insight into the dynamics of traveling wave solutions and leads to a new interpretation of the mathematical notions of pulled and pushed waves.
Removal of two large-scale cosmic microwave background anomalies after subtraction of the integrated Sachs-Wolfe effect

International audienceContext. Although there is currently a debate over the significance of the claimed large-scale anomalies in the cosmic microwave background (CMB), their existence is not totally dismissed. In parallel to the debate over their statistical significance, recent work has also focussed on masks and secondary anisotropies as potential sources of these anomalies.Aims. In this work we investigate simultaneously the impact of the method used to account for masked regions as well as the impact of the integrated Sachs-Wolfe (ISW) effect, which is the large-scale secondary anisotropy most likely to affect the CMB anomalies. In this sense, our work is an update of previous works. Our aim is to identify trends in CMB data from different years and with different mask treatments.Methods. We reconstruct the ISW signal due to 2 Micron All-Sky Survey (2MASS) and NRAO VLA Sky Survey (NVSS) galaxies, effectively reconstructing the low-redshift ISW signal out to z ~ 1. We account for regions of missing data using the sparse inpainting technique. We test sparse inpainting of the CMB, large scale structure and ISW and find that it constitutes a bias-free reconstruction method suitable to study large-scale statistical isotropy and the ISW effect.Results. We focus on three large-scale CMB anomalies: the low quadrupole, the quadrupole/octopole alignment, and the octopole planarity. After sparse inpainting, the low quadrupole becomes more anomalous, whilst the quadrupole/octopole alignment becomes less anomalous. The significance of the low quadrupole is unchanged after subtraction of the ISW effect, while the trend amongst the CMB maps is that both the low quadrupole and the quadrupole/octopole alignment have reduced significance, yet other hypotheses remain possible as well (e.g. exotic physics). Our results also suggest that both of these anomalies may be due to the quadrupole alone. While the octopole planarity significance is reduced after inpainting and after ISW subtraction, however, we do not find that it was very anomalous to start with
Aggregating sets of von Neumann-Morgenstern utilities

International audienceWe analyze the aggregation problem without the assumption that individuals and society have fully determined and observable preferences. More precisely, we endow individuals ans society with sets of possible von Neumann-Morgenstern utility functions over lotteries. We generalize the classical neutrality assumption to this setting and characterize the class of neutral social welfare function. This class turns out to be considerably broader for indeterminate than for determinate utilities, where it basically reduces to utilitarianism. In particular, aggregation rules may differ by the relationship between individual and social indeterminacy. We characterize several subclasses of neutral aggregation rules and show that utilitarian rules are those that yield the least indeterminate social utilities, although they still fail to systematically yield a determinate social utility
p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells.
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P38 CONTROLS THE MESODERMAL COMMITMENT OF ES CELLS

International audienceEmbryonic stem (ES) cells differentiate in vitro into all cell lineages. We previously found that the p38 mitogen activated kinase (p38MAPK) pathway controls the commitment of ES cells toward either cardiomyogenesis (p38 on) or neurogenesis (p38 off ). In this study, we show that p38α knock-out ES cells do not differentiate into cardiac, endothelial, smooth muscle, and skeletal muscle lineages. Reexpression of p38MAPK in these cells partially rescues their mesodermal differentiation defects and corrects the high level of spontaneous neurogenesis of knock-out cells. Wild-type ES cells were treated with a p38MAPK-specific inhibitor during the differentiation process. These experiments allowed us to identify 2 early independent successive p38MAPK functions in the formation of mesodermal lineages. Further, the first one correlates with the regulation of the expression of Brachyury, an essential mesodermal-specific transcription factor, by p38MAPK. In conclusion, by genetic and biochemical approaches, we demonstrate that p38MAPK activity is essential for the commitment of ES cell into cardiac, endothelial, smooth muscle, and skeletal muscle mesodermal lineages
Couples, PMTCT programs and infant feeding decision-making in Ivory Coast.

International audienceIn Sub-Saharan Africa, prevention of HIV pediatric infection due to breastfeeding requires turning to alternatives to prolonged breastfeeding: artificial feeding or exclusive breastfeeding with early weaning. Choosing a preventive option and applying it does not only depend upon the mother but also on the father and more specifically on couple interactions. To date, not enough studies have considered this question. In Abidjan, Ivory Coast, HIV-positive women and their infants were followed over two years in Ditrame Plus, a prevention of mother-to-child transmission (PMTCT) project. Using data from this project and from interviews conducted with couples and women, we analyzed the construction of decisions and practices concerning the application of preventive infant feeding options. Differences may be found between women and men in discourses regarding their attitudes, which are in part related to their conceptions of motherhood and fatherhood. We found that when men know their wife is HIV positive and are involved in the PMTCT project, they play an active role in applying the advice received. However, women do not always need the support of their spouse to undertake preventative behaviour. The project team also plays an important role in the adoption of such by women and men. The implementation of preventive options is a complex process in which three groups of actors (women, men and the project team) interact. In order to optimize PMTCT programs for couples, it is essential that this dynamic be taken into account