pinecone/core-2020-05-10-deduplication huggingface dataset:
Operator analysis of physical states on magnetized T2/ZN orbifolds

AbstractWe discuss an effective way for analyzing the system on the magnetized twisted orbifolds in operator formalism, especially in the complicated cases T2/Z3, T2/Z4 and T2/Z6. We can obtain the exact and analytical results which can be applicable for any larger values of the quantized magnetic flux M, and show that the (non-diagonalized) kinetic terms are generated via our formalism and the number of the surviving physical states are calculable in a rigorous manner by simply following usual procedures in linear algebra in any case. Our approach is very powerful when we try to examine properties of the physical states on (complicated) magnetized orbifolds T2/Z3, T2/Z4, T2/Z6 (and would be in other cases on higher-dimensional torus) and could be an essential tool for actual realistic model construction based on these geometries. (Note: This article is registered under preprint number: arXiv:1409.5421.
Kernel and symbol criteria for Schatten classes and r-nuclearity on compact manifolds

AbstractIn this Note, we present criteria on both symbols and integral kernels ensuring that the corresponding operators on compact manifolds belong to Schatten classes. A specific test for nuclearity is established as well as the corresponding trace formulae. In the special case of compact Lie groups, kernel criteria in terms of (locally and globally) hypoelliptic operators are also given. A notion of invariant operator and its full symbol associated with an elliptic operator are introduced. Some applications to the study of r-nuclearity on Lp spaces are also obtained
Statistical interpretation of the spatial distribution of current 130 GeV γ-ray line signal within the dark matter annihilation scenario

AbstractRecently, several groups identified a tentative γ-ray line signal with energy ∼130 GeV in the central Galaxy from the Fermi-LAT data. Such a γ-ray line can be interpreted as the signal of dark matter annihilation. However, the offset ∼220 pc (1.5°) of the center of the most prominent signal region from the Galactic center Sgr A⋆ has been thought to challenge the dark matter annihilation interpretation. Considering the fact that such a 130 GeV γ-ray line signal consists of only ∼14 photons, we suggest that the “imperfect” consistency of these photons with the expected dark matter distribution is due to the limited statistics. The offset will be smaller as more signal photons have been collected in the near future. Our Monte Carlo simulation supports the above speculation
The sea urchin metallothionein system: Comparative evaluation of the SpMTA and SpMTB metal-binding preferences

AbstractMetallothioneins (MTs) constitute a superfamily of ubiquitous metal-binding proteins of low molecular weight and high Cys content. They are involved in metal homeostasis and detoxification, amongst other proposed biological functions. Two MT isoforms (SpMTA and SpMTB) have been reported in the echinoderm Strongylocentrotus purpuratus (sea urchin), both containing 20 Cys residues and presenting extremely similar sequences, although showing distinct tissular and ontogenic expression patterns. Although exhaustive information is available for the Cd(II)-SpMTA complex, this including the full resolution of its 3D structure, no data has been reported concerning either SpMTA Zn(II) and Cu(I) binding properties, or the characterization of SpMTB at protein level. In this work, both the SpMTA and SpMTB isoforms, as well as their separate α and β domains, have been recombinantly synthesized in the presence of Zn(II), Cd(II) or Cu(II), and the corresponding metal complexes have been analyzed using electrospray mass spectrometry, and CD, ICP-AES and UV–vis spectroscopies. The results clearly show a better performance of isoform A when binding Zn(II) and Cd(II), and of isoform B when coordinating Cu(I). Thus, our results confirm the differential metal binding preference of SpMTA and SpMTB, which, together with the reported induction pattern of the respective genes, highlights how also in Echinodermata the MT polymorphism may be linked to the evolution of different physiological roles
1-Year Outcomes After Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expandable Valves Results From the CHOICE Randomized Clinical Trial

AbstractBackgroundThe use of a balloon-expandable transcatheter heart valve previously resulted in a greater rate of device success compared with a self-expandable transcatheter heart valve.ObjectivesThe aim of this study was to evaluate clinical and echocardiographic outcome data at longer term follow-up.MethodsThe investigator-initiated trial randomized 241 high-risk patients with symptomatic severe aortic stenosis and anatomy suitable for treatment with both balloon- and self-expandable transcatheter heart valves to transfemoral transcatheter aortic valve replacement with either device. Patients were followed-up for 1 year, with assessment of clinical outcomes and echocardiographic evaluation of valve function.ResultsAt 1 year, the rates of death of any cause (17.4% vs. 12.8%; relative risk [RR]: 1.35; 95% confidence interval [CI]: 0.73 to 2.50; p = 0.37) and of cardiovascular causes (12.4% vs. 9.4%; RR: 1.32; 95% CI: 0.63 to 2.75; p = 0.54) were not statistically significantly different in the balloon- and self-expandable groups, respectively. The frequencies of all strokes (9.1% vs. 3.4%; RR: 2.66; 95% CI: 0.87 to 8.12; p = 0.11) and repeat hospitalization for heart failure (7.4% vs. 12.8%; RR: 0.58; 95% CI: 0.26 to 1.27; p = 0.19) did not statistically significantly differ between the 2 groups. Elevated transvalvular gradients during follow-up were observed in 4 patients in the balloon-expandable group (3.4% vs. 0%; p = 0.12); all were resolved with anticoagulant therapy, suggesting a thrombotic etiology. More than mild paravalvular regurgitation was more frequent in the self-expandable group (1.1% vs. 12.1%; p = 0.005).ConclusionsDespite the higher device success rate with the balloon-expandable valve, 1-year follow-up of patients in CHOICE (Randomized Comparison of Transcatheter Heart Valves in High Risk Patients With Severe Aortic Stenosis: Medtronic CoreValve Versus Edwards SAPIEN XT Trial), with limited statistical power, revealed clinical outcomes after transfemoral transcatheter aortic valve replacement with both balloon- and self-expandable prostheses that were not statistically significantly different. (A Comparison of Transcatheter Heart Valves in High Risk Patients With Severe Aortic Stenosis: The CHOICE Trial; NCT01645202
Petrogenesis of OIB-like basaltic volcanic rocks in a continental collision zone: Late Cenozoic magmatism of Eastern Iran

AbstractHundreds of compositionally diverse volcanoes have erupted on the Turkish–Iranian Plateau in the last 15Myr, attributed to one or more of the processes of Middle Miocene Tethyan slab break-off, localised lithospheric delamination and small-scale convection. Magmatism post-dates the initial Late Eocene or Early Oligocene Arabia–Eurasia collision by >10Myr. By contrast, in the east of the plateau in Eastern Iran there has been intermittent magmatism from the Late Oligocene to the Quaternary. Magma types include alkali basalt flows and scoria cones and adakite-like intermediate–felsic lavas and domes. New elemental and Nd–Sr–Pb–Hf isotope data from Quaternary mafic alkaline flows near Quchan in the Meshkan area in the NE of the country are combined with existing data from Miocene–Quaternary volcanic centres in the Binalud Range and the Nayband/Neh Fault zones. These mafic, incompatible element-enriched rocks, with positive Nb–Ta anomalies, are OIB-like and are argued to have formed by low-degree melting of a heterogeneous mantle source which contained DMM- and EMII-like components. At least some of the melting took place in the garnet stability field. Significant crustal contamination during magma ascent is recognised in the Nayband/Neh samples. Penecontemporaneous adakite-like rocks are argued to be high-pressure fractionates of basaltic melts which may have a separate source to the OIB-like basalts. Late Cenozoic mantle melting was aided by (1) localised extension and (2) enhanced small-scale asthenospheric convection related to Makran subduction, low mantle viscosity owing to the prior Tethyan subduction history of the region, and possibly edge-driven convection on the margin of the thickened Zagros lithosphere
The spatial effect of protein deuteration on nitroxide spin-label relaxation: Implications for EPR distance measurement

AbstractPulsed electron–electron double resonance (PELDOR) coupled with site-directed spin labeling is a powerful technique for the elucidation of protein or nucleic acid, macromolecular structure and interactions. The intrinsic high sensitivity of electron paramagnetic resonance enables measurement on small quantities of bio-macromolecules, however short relaxation times impose a limit on the sensitivity and size of distances that can be measured using this technique. The persistence of the electron spin-echo, in the PELDOR experiment, is one of the most crucial limitations to distance measurement. At a temperature of around 50K one of the predominant factors affecting persistence of an echo, and as such, the sensitivity and measurable distance between spin labels, is the electron spin echo dephasing time (Tm). It has become normal practice to use deuterated solvents to extend Tm and recently it has been demonstrated that deuteration of the underlying protein significantly extends Tm. Here we examine the spatial effect of segmental deuteration of the underlying protein, and also explore the concentration and temperature dependence of highly deuterated systems
Search for lepton flavour violating decays of the Higgs boson to eτ and eμ in proton–proton collisions at s=8 TeV

AbstractA direct search for lepton flavour violating decays of the Higgs boson (H) in the H→eτ and H→eμ channels is described. The data sample used in the search was collected in proton–proton collisions at s=8 TeV with the CMS detector at the LHC and corresponds to an integrated luminosity of 19.7 fb−1. No evidence is found for lepton flavour violating decays in either final state. Upper limits on the branching fractions, B(H→eτ)<0.69% and B(H→eμ)<0.035%, are set at the 95% confidence level. The constraint set on B(H→eτ) is an order of magnitude more stringent than the existing indirect limits. The limits are used to constrain the corresponding flavour violating Yukawa couplings, absent in the standard model
Observation of isoscalar multipole strengths in exotic doubly-magic 56Ni in inelastic α scattering in inverse kinematics

AbstractThe Isoscalar Giant Monopole Resonance (ISGMR) and the Isoscalar Giant Dipole Resonance (ISGDR) compression modes have been studied in the doubly-magic unstable nucleus 56Ni. They were measured by inelastic α-particle scattering in inverse kinematics at 50 MeV/u with the MAYA active target at the GANIL facility. The centroid of the ISGMR has been obtained at Ex=19.1±0.5 MeV. Evidence for the low-lying part of the ISGDR has been found at Ex=17.4±0.7 MeV. The strength distribution for the dipole mode shows similarity with the prediction from the Hartree–Fock (HF) based random-phase approximation (RPA) [1]. These measurements confirm inelastic α-particle scattering as a suitable probe for exciting the ISGMR and the ISGDR modes in radioactive isotopes in inverse kinematics
Infodemiological data of Ironman Triathlon in the study period 2004–2013

AbstractThis article reports data concerning the Internet-related activities and interest for Ironman Triathlon competition. Google Trends (GT) was used and mined from 2004 onwards. The interest for Ironman Triathlon was found to be cyclic over time. The Triathlon-related Internet activities negatively correlated with the number of finishers per year (Pearson׳s correlation r=−0.690, p-value<0.05), while an increasing participation of female athletes who were less likely to surf the Internet could be noticed (r=−0.811, p-value<0.05). Further, younger athletes, who were more likely to access the web, were underrepresented in the Ironman Triathlon event. Moreover, there was a correlation between the biking time and the Internet query volumes (r=0.590, p-value<0.05), and, in particular, for the male athletes (r=0.664, p-value<0.05). Finally, the countries which most contributed to the Internet query volumes were those with the highest number of medals
The effect of the OPRM1 and DRD4 polymorphisms on the relation between attentional bias and alcohol use in adolescence and young adulthood

ABSTRACTBackgroundThe incentive sensitization theory posits that in the transition from sporadic to problematic alcohol use, the incentive value of alcohol increases (wanting) while its hedonic effects (liking) do not change or decreases. The effect of the OPRM1 c.118A>G polymorphism, associated with liking and wanting, and the DRD4-VNTR polymorphism, related to wanting, on the relation between attentional bias and alcohol use was investigated.MethodsA total of 195 young adolescents (Study 1) and 86 young adult male heavy drinkers (Study 2) completed a visual probe test. Saliva samples were collected to test both polymorphisms.ResultsIn Study 1, attentional bias was positively associated with adolescent alcohol use only for OPRM1 G-allele carriers. In Study 2, attentional bias was positively associated with problem drinking for carriers of a DRD4 long allele.DiscussionIt is tentatively proposed that an attentional bias for alcohol is related most strongly to liking and wanting in early adolescents, while in young adults, an attentional bias may reflect wanting. In addition, individual differences associated with two both genetic markers should be taken into account when examining the relation between attentional bias and alcohol use
Seasonal variations of solar neutrino rates in lithium detector

AbstractThe presence of two monochromatic lines of approximately equal intensity: 7Be- and pep-neutrinos in the sensitivity plot of lithium detector makes the pattern of the seasonal variations of the effect from solar neutrinos very characteristic in case if the long-wave vacuum oscillations are realized. This can give the very high accuracy in the measurement of the parameters of neutrino oscillations especially if combined with the results obtained by the detector sensitive mainly to 7Be-line like BOREXINO or KamLAND
V–A hadronic tau decays: A laboratory for the QCD vacuum

AbstractALEPH/OPAL data on the V–A spectral functions from hadronic τ decays are used in connection with a set of Laplace transform sum rules (LSR) for fixing the size of the QCD vacuum condensates up to dimension 18. Our results favor the ones from large-Nc QCD within the minimal hadronic approximation (MHA) and show a violation of about a factor 2–5 of the vacuum saturation estimate of the dimension-six to -ten condensates. We scrutinize the different determinations of the QCD vacuum condensates using τ-decays data. After revisiting some of the existing results, we present coherent values of the condensates from different methods
Finite Blaschke products and the construction of rational Γ-inner functions

AbstractLetΓ=def{(z+w,zw):|z|≤1,|w|≤1}⊂C2. A Γ-inner function is a holomorphic map h from the unit disc D to Γ whose boundary values at almost all points of the unit circle T belong to the distinguished boundary bΓ of Γ. A rational Γ-inner function h induces a continuous map h|T from T to bΓ. The latter set is topologically a Möbius band and so has fundamental group Z. The degree of h is defined to be the topological degree of h|T. In a previous paper the authors showed that if h=(s,p) is a rational Γ-inner function of degree n then s2−4p has exactly n zeros in the closed unit disc D−, counted with an appropriate notion of multiplicity. In this paper, with the aid of a solution of an interpolation problem for finite Blaschke products, we explicitly construct the rational Γ-inner functions of degree n with the n zeros of s2−4p prescribed
Pre-Capillary, Combined, and Post-Capillary Pulmonary Hypertension A Pathophysiological Continuum

AbstractBackgroundPulmonary hypertension (PH) is hemodynamically classified as pre-capillary (as seen in idiopathic pulmonary arterial hypertension [IPAH]) or post-capillary (as seen in heart failure with preserved ejection fraction [HFpEF]). Overlaps between these conditions exist. Some patients present with risk factors for left heart disease but pre-capillary PH, whereas patients with HFpEF may have combined pre- and post-capillary PH.ObjectivesThis study sought to further characterize similarities and differences among patient populations with either PH-HFpEF or IPAH.MethodsWe used registry data to analyze clinical characteristics, hemodynamics, and treatment responses in patients with typical IPAH (<3 risk factors for left heart disease; n = 421), atypical IPAH (≥3 risk factors for left heart disease; n = 139), and PH-HFpEF (n = 226) receiving PH-targeted therapy.ResultsCompared with typical IPAH, patients with atypical IPAH and PH-HFpEF were older, had a higher body mass index, had more comorbidities, and had a lower 6-min walking distance, whereas mean pulmonary artery pressure (46.9 ± 13.3 mm Hg vs. 43.9 ± 10.7 mm Hg vs. 45.7 ± 9.4 mm Hg, respectively) and cardiac index (2.3 ± 0.8 l/min/m2 vs. 2.2 ± 0.8 l/min/m2 vs. 2.2 ± 0.7 l/min/m2, respectively) were comparable among groups. After initiation of targeted PH therapies, all groups showed improvement in exercise capacity, functional class, and natriuretic peptides from baseline to 12 months, but treatment effects were less pronounced in patients with PH-HFpEF than typical IPAH; with atypical IPAH in between. Survival rates at 1, 3, and 5 years were almost identical for the 3 groups.ConclusionsPatients with atypical IPAH share features of both typical IPAH and PH-HFpEF, suggesting that there may be a continuum between these conditions
Clinical impact of the ERBP Working Group 2010 Recommendations for the anemia management in chronic kidney disease not on dialysis: ACERCA study1

AbstractBackground and objectiveThe Anemia Working Group of ERBP in 2010 recommended a target hemoglobin (Hb) level in the range of 11-12g/dL, without intentionally exceeding 13g/dL during the treatment with erythropoiesis stimulating agents (ESAs). This study evaluated if there was a clinical impact of this statement in the anemia management of chronic kidney disease (CKD) patients treated with ESAs not on dialysis in routine clinical practice in Spain.MethodsThis was an observational and cross-sectional study carried out in CKD patients not on dialysis in Spain who initiated ESA treatment (naïve), or were shifted from a previous ESA to another ESAs (converted) since January 2011.ResultsOf 441 patients evaluated, 67.6% were naïve and 32.4% were converted. At the study visit, 42.5% of naïve patients achieved the Hb target of 11-12g/dL, with a mean Hb of 11.3±1.3 g/dL (vs 10.1±0.9g/dL at the start of ESA therapy). Only 35.3% of converted patients maintained Hb levels within the recommended target at the study visit. Yet, 8.2% of naïve patients and 7.9% of those converted had Hb levels >13g/dL. Hb levels were similar across subgroups of patients, regardless of the presence of significant comorbidities.ConclusionsAnemia management in CKD patients treated with ESAs by Spanish nephrologists seems to be aimed at preventing Hb levels <11g/dL, while <50% of patients were within the narrow recommended Hb target range. This, together with the lack of individualization in Hb targets according to patients’ comorbidities show that there is still room for improvement in renal anemia management in the clinical setting
Governance struggles and policy processes in disaster risk reduction: A case study from Nepal

AbstractIn the neo-liberal climate of reduced responsibility for the state, alongside global platforms established to implement the Hyogo Framework for Action, a new arena opens for a multitude of stakeholders to engage in disaster risk reduction (DRR). The key role that the state can play in instituting effective DRR tends to receive little attention, yet in situations where the state apparatus is weak, such as in Nepal, it becomes evident that integrating DRR into development is a particularly challenging task. Due to the political situation in Nepal, progress has been stalled in providing a legislative context conducive to effective DRR. This paper traces the evolution of key DRR initiatives that have been developed in spite of the challenging governance context, such as the National Strategy for Disaster Risk Management and the Nepal Risk Reduction Consortium. Informed by in-depth interviews with key informants, the argument is made that the dedicated efforts of national and international non-governmental organisations, multilateral agencies and donors in mainstreaming DRR demonstrate that considerable progress can be made even where government departments are protective of their own interests and are slow to enact policies to support DRR. The paper suggests however, that without stronger engagement of key political actors the prospects for further progress in DRR may be limited. The findings have implications for other post-conflict countries or weak states engaging in DRR
A predictive 3-3-1 model with A4 flavor symmetry

AbstractWe propose a predictive model based on the SU(3)C⊗SU(3)L⊗U(1)X gauge group supplemented by the A4⊗Z3⊗Z4⊗Z6⊗Z16 discrete group, which successfully describes the SM fermion mass and mixing pattern. The small active neutrino masses are generated via inverse seesaw mechanism with three very light Majorana neutrinos. The observed charged fermion mass hierarchy and quark mixing pattern are originated from the breaking of the Z4⊗Z6⊗Z16 discrete group at very high scale. The obtained values for the physical observables for both quark and lepton sectors are in excellent agreement with the experimental data. The model predicts a vanishing leptonic Dirac CP violating phase as well as an effective Majorana neutrino mass parameter of neutrinoless double beta decay, with values mββ=2 and 48 meV for the normal and the inverted neutrino mass hierarchies, respectively
Ding–Iohara–Miki symmetry of network matrix models

AbstractWard identities in the most general “network matrix model” from [1] can be described in terms of the Ding–Iohara–Miki algebras (DIM). This confirms an expectation that such algebras and their various limits/reductions are the relevant substitutes/deformations of the Virasoro/W-algebra for (q,t) and (q1,q2,q3) deformed network matrix models. Exhaustive for these purposes should be the Pagoda triple-affine elliptic DIM, which corresponds to networks associated with 6d gauge theories with adjoint matter (double elliptic systems). We provide some details on elliptic qq-characters
Degrees of chloroquine resistance in Plasmodium – Is the redox system involved?

AbstractChloroquine (CQ) was once a very effective antimalarial drug that, at its peak, was consumed in the hundreds of millions of doses per year. The drug acts against the Plasmodium parasite during the asexual intra-erythrocytic phase of its lifecycle. Unfortunately, clinical resistance to this drug is now widespread. Questions remain about precisely how CQ kills malaria parasites, and by what means some CQ-resistant (CQR) parasites can withstand much higher concentrations of the drug than others that also fall in the CQR category. In this review we investigate the evidence for and against the proposal that CQ kills parasites by generating oxidative stress. Further, we examine a long-held idea that the glutathione system of malaria parasites plays a role in CQ resistance. We conclude that there is strong evidence that glutathione levels modulate CQ response in the rodent malaria species Plasmodium berghei, but that a role for redox in contributing to the degree of CQ resistance in species infectious to humans has not been firmly established