pinecone/core-2020-05-10-deduplication huggingface dataset:
Measurement of electroweak production of a W boson and two forward jets in proton-proton collisions at √s = 8 TeV

A measurement is presented of the cross section for the electroweak production of a W boson in association with two jets in proton-proton collisions at a center-of-mass energy of 8 TeV. The data set was collected with the CMS detector and corresponds to an integrated luminosity of 19.3 fb−1. The measured fiducial cross section for W bosons decaying to electrons or muons and for pTj1> 60 GeV, pTj2> 50 GeV, |ηj| < 4.7, and mjj> 1000 GeV is 0.42 ± 0.04 (stat) ± 0.09 (syst) ± 0.01 (lumi) pb. This result is consistent with the standard model leading-order prediction of 0.50 ± 0.02 (scale) ± 0.02 (PDF) pb obtained with MadGraph5_amc@nlo 2.1 interfaced to pythia 6.4. This is the first cross section measurement for this process.The Scientific and Technical Research Council of Turkey, and Turkish Atomic Energy Authorit
Reducing Uncertainty in PHM by Accounting for Human Factors - A Case Study in the Biopharmaceutical Industry

The ultimate goal of prognostics within Through-life Engineering Services (TES) is to accurately predict the remaining useful life (RUL) of components. Prognostic frameworks inherently presume that there is predictability in the failure rate of the system, i.e. a system experiencing exclusively stochastic failure events cannot, by definition, be predictable. Prediction model uncertainties must be bound in some logical way. Therefore, to achieve an accurate prognostic model, uncertainty must first be reduced through the identification and elimination of the root causes of random failure events. This research investigates human error in maintenance activities as a major cause of random failure events, using a case study from the biopharmaceutical industry. Elastomer failures remain the number one contamination risk in this industry and data shows unexplained variability in the lifetime of real components when compared to accelerated lifetime testing in the lab environment. Technician error during installation and maintenance activities of elastomers is one possible cause for this and this research explores how these errors can be eliminated, reduced, or accounted for within the reliability modeling process. The initial approach followed was to improve technician training in order to reduce errors and thereby reduce the variability of random failure events. Subsequent data has shown an improvement in key metrics with failures now more closely matching data from lab testing. However, there is scope for further improvements and future research will explore the role of performance influencing factors in the maintenance task to identify additional causes of variation. These factors may then be incorporated as a process variable in a prognostics and health management (PHM) model developed for the system. The paper will present these data fusion approaches accounting for human factors as a roadmap to improving PHM model reliability
Requirements for global elimination of hepatitis B: a modelling
                study

Background: Despite the existence of effective prevention and treatment interventions, hepatitis B virus (HBV) infection continues to cause nearly 1 million deaths each year. WHO aspires to global control and elimination of HBV infection. We aimed to evaluate the potential impact of public health interventions against HBV, propose targets for reducing incidence and mortality, and identify the key developments required to achieve them.
Methods: We developed a simulation model of the global HBV epidemic, incorporating data on the natural history of HBV, prevalence, mortality, vaccine coverage, treatment dynamics, and demographics. We estimate the impact of current interventions and scaling up of existing interventions for prevention of infection and introducing wide-scale population screening and treatment interventions on the worldwide epidemic.
Findings: Vaccination of infants and neonates is already driving a large decrease in new infections; vaccination has already prevented 210 million new chronic infections by 2015 and will have averted 1·1 million deaths by 2030. However, without scale-up of existing interventions, our model showed that there will be a cumulative 63 million new cases of chronic infection and 17 million HBV-related deaths between 2015 and 2030 because of ongoing transmission in some regions and poor access to treatment for people already infected. A target of a 90% reduction in new chronic infections and 65% reduction in mortality could be achieved by scaling up the coverage of infant vaccination (to 90% of infants), birth-dose vaccination (to 80% of neonates), use of peripartum antivirals (to 80% of hepatitis B e antigen-positive mothers), and population-wide testing and treatment (to 80% of eligible people). These interventions would avert 7·3 million deaths between 2015 and 2030, including 1·5 million cases of cancer deaths. An elimination threshold for incidence of new chronic infections would be reached by 2090 worldwide. The annual cost would peak at US$7·5 billion worldwide ($3·4 billion in low-income and lower-middle-income countries), but decrease rapidly and this would be accelerated if a cure is developed. Interpretation: Scale-up of vaccination coverage, innovations in scalable options for prevention of mother-to-child transmission, and ambitious population-wide testing and treatment are needed to eliminate HBV as a major public health threat. Achievement of these targets could make a major contribution to one of the Sustainable Development Goals of combating hepatitis
Understanding dementia amongst indigenous Australians

Dementia is a growing health and social concern for all Australians. It has been previously thought that Indigenous Australians did not live long enough to get dementia (Pollitt 1997). Interestingly, Indigenous Australians have reported dementia as being a 'whitefella sickness' (Woenne-Green 1995) as 'the word dementia has no meaning’ in Indigenous terms (Fox 1994; Zann 1994). More 'recently dementia has been described as a 'sick spirit' (Arabena 2007). However, as the life expectancy of Indigenous people increases, and they grow older they will encounter causes of death and disability not unlike their non-Indigenous counterparts, including increased presentations of dementia (Arabena 2007)
Sexual conflict selects for male and female reproductive characters.

BACKGROUND: Strict genetic monogamy leads to sexual harmony because any trait that decreases the fitness of one sex also decreases the fitness of the other. Any deviation from monogamy increases the potential for sexual conflict. Conflict is further enhanced by sperm competition, and given the ubiquity of this phenomenon, sexual conflict is rife. In support of theory, experimentally enforced monogamy leads to the evolution of sexual benevolence. In contrast, with multiple mating, males evolve traits causing massive female fitness reductions when female evolution is restrained. Theory also predicts increased investment in spermatogenesis when sperm competition risk is high. While this supposition has correlational support, cause and effect has yet to be firmly established. RESULTS: By enforcing monogamy or polyandry in yellow-dung-fly lines, we have shown experimentally that males from polyandrous treatments evolved larger testes. Furthermore, females from this treatment evolved larger accessory sex glands. These glands produce a spermicidal secretion, so larger glands could increase female ability to influence paternity. Using molecular techniques, we have shown that, consistent with this idea, males' success as second mates is reduced in females from the polyandrous treatment. Nevertheless, males from polyandrous lines achieve higher paternity during sperm competition, and this finding further supports the testis evolution patterns. CONCLUSIONS: These results provide direct experimental support for macroevolutionary patterns of testis size evolution. Furthermore, we have shown that sperm competition selects for traits likely to be important in sexual conflicts over paternity, a result only previously demonstrated in Drosophila melanogaster
Does chemical cross-linking with NHS esters reflect the chemical equilibrium of protein-protein noncovalent interactions in solution?

Chemical cross-linking in combination with matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has emerged as a powerful tool to study non-covalent protein complexes. Nevertheless, there are still many questions to answer: Does the amount of detected cross-linked complex correlate with the amount of protein complex in solution? In which concentration and affinity range is specific cross-linking possible? In order to answer these questions, we performed systematic cross-linking studies with two complexes using the N8\ud
hydroxysuccinimidyl ester disuccinimidyl suberate (DSS): i) NCoA-1 and mutants of the interacting peptide STAT6Y, covering a KD range of 30 nM to > 25 μM and ii) α-thrombin and basic pancreatic trypsin inhibitor (BPTI), which shows a buffer dependent KD value between 100 and 320 μM. Samples were analyzed by MALDI-MS. For NCoA-1•STAT6Y, a good correlation of the amount of cross-linked species with the calculated fraction of complex present in solution was observed. Thus, chemical cross-linking in combination with MALDI-MS can be used to rank binding affinities. The specificity of complex formation for the mid-affinity range up to about KD ≈ 25 μM could be proven by comparing against a non-binding peptide and by studying the concentration dependence. In order to study in which affinity range specific cross-linking can be applied, the weak α-thrombin•BPTI complex was investigated. Although variations of the sodium concentration can change the dissociation constant up to 3-fold for this interaction, no significant effect on the amount of detected complex was observed at different peptide concentrations. Our interpretation of this result is that the detected complex is not specific, but a nonspecifically cross-linked species. Consequently, chemical cross-linking is not applicable to low-affinity complexes with KD >> 25 μM with the experimental approach used in this study
How useful is Growth Literature for Policies in the Developing Countries?

This paper examines the growing gap between the theoretical and empirical growth literature and the policy needs of the developing economies. Growth literature has focussed mainly on the long term growth outcomes, but policy makers of the developing economies need rapid improvements in the short to medium term growth rates; see Pritchett (2006). This paper argues that this gap can be reduced by distinguishing between the short to medium term dynamic effects of policies from their long run equilibrium effects.  With data on Singapore, Malaysia and Thailand we show that an extended version of the Solow (1956) model is well suited for this purpose. This is despite the common belief that the Solow model has no use for policy and is not applicable to the developing countries. We find that the short to medium term growth effects of the investment ratio are quite significant and they may persist for up to 10 years.
Using mental-modelling to explore how irrigators in the Murray-Darling Basin make water-use decisions

Study region: Water stress and over-allocation are at the forefront of water management and policy challenges in Australia, especially in the Murray–Darling Basin (MDB). Because irrigated agriculture is a major social and economic component of the MDB, farmer decision-making plays a major role in water sustainability in the region. Study focus: This study used a fuzzy cognitive mapping methodology, ‘mental modeling’, to understand the perceived constraints of irrigator water-use decisions in the MDB, for two different types of irrigation: permanent and annual crops. The approach elicits and documents irrigator insights into the complex and networked nature of irrigation water use decisions in relation to farm-based dynamics. New hydrological insights for the region: Results suggest support for greater local and irrigator involvement in water management decisions. Many, if not most, of the irrigators understood the need for, or at least the inevitability of, governmental policies and regulations. However, a lack of accountability, predictability, and transparency has added to the uncertainty in farm-based water decision-making. Irrigators supported the concept of environmental sustainability, although they might not always agree with how the concept is implemented. The mental modelling approach facilitated knowledge sharing among stakeholders and can be used to identify common goals. Future research utilizing the mental modelling approach may encourage co-management and knowledge partnerships between irrigators, water managers and government officials.Ellen M. Douglas, Sarah Ann Wheeler, David J. Smith, Ian C. Overton, Steven A. Gray, Tanya M. Doody, Neville D. Crossma
Air entrainment in dip coating under reduced air pressures

YesThis study examines experimentally and for the first time the effect of reduced air pressure on dynamic wetting. The purpose is to assess the role of air viscosity on dynamic wetting failure which hitherto has been speculated on but not measured. In this paper we used dip coating as the model experimental flow and report data on air entrainment velocity Vae we measured with a series of silicone oils in a range of viscosities in a vacuum chamber where the pressure can be reduced from atmospheric down to a few mbar when the mean molecular free path of air is large and air ceases to have a viscosity. To complement earlier work, we carried out the experiments with a range of substrates of varying roughness. The substrates were chosen so that for each one, their two sides differ in roughness. This enables simultaneous comparative observation of their wetting performance and reduces the experimental error in assessing the role of roughness. The data presented here capture the effects of viscosity, roughness and air pressure but the important result of this study is that Vae can be increased considerably (exponentially) when the pressure is reduced with the suggestion that Vae approaches infinity as pressure approaches zero. In other words, the role of the surrounding air viscosity is important in dynamic wetting. The data from this study have significant implication to the fundamental understanding of dynamic wetting. Indeed they form the missing data link to fully understand this phenomenon. The data presented in this work also confirm the complex role of roughness, in that it can increase or decrease the air entrainment speed depending on the value on the viscosity of the coating solution. The results presented in this paper are very useful in practice as they imply that if one chooses carefully roughness one can coat viscous formulation at unexpectedly very high speeds with a moderate vacuum (50 mbar typically)
Asymptotic safety in O(N) scalar models coupled to gravity

We extend recent results on scalar-tensor theories to the case of an O( N)-invariant multiplet. Some exact fixed point solutions of the RG flow equations are discussed. We find that also in the functional context, on employing a standard "type-I" cutoff, too many scalars destroy the gravitational fixed point. For d= 3 we show the existence of the gravitationally dressed Wilson-Fisher fixed point also for N> 1. We discuss also the results of the analysis for a different, scalar-free, coarse-graining scheme. © 2015 The Authors
Measurement of the tt¯γ production cross section in proton-proton collisions at √s=8 TeV with the ATLAS detector

The cross section of a top-quark pair produced in association with a photon is measured in proton-proton collisions at a centre-of-mass energy of s√=8 TeV with 20.2 fb−1 of data collected by the ATLAS detector at the Large Hadron Collider in 2012. The measurement is performed by selecting events that contain a photon with transverse momentum pT > 15 GeV, an isolated lepton with large transverse momentum, large missing transverse momentum, and at least four jets, where at least one is identified as originating from a b-quark. The production cross section is measured in a fiducial region close to the selection requirements. It is found to be 139 ± 7 (stat.) ± 17 (syst.) fb, in good agreement with the theoretical prediction at next-to-leading order of 151 ± 24 fb. In addition, differential cross sections in the fiducial region are measured as a function of the transverse momentum and pseudorapidity of the photon
Catch me if you can: is there a "runaway-mass" black hole in the Orion Nebula Cluster?

We investigate the dynamical evolution of the Orion Nebula Cluster (ONC) by means of direct N-body integrations. A large fraction of residual gas was probably expelled when the ONC formed, so we assume that the ONC was much more compact when it formed compared with its current size, in agreement with the embedded cluster radius-mass relation from Marks & Kroupa. Hence, we assume that few-body relaxation played an important role during the initial phase of evolution of the ONC. In particular, three-body interactions among OB stars likely led to their ejection from the cluster and, at the same time, to the formation of a massive object via "runaway" physical stellar collisions. The resulting depletion of the high-mass end of the stellar mass function in the cluster is one of the important points where our models fit the observational data. We speculate that the runaway-mass star may have collapsed directly into a massive black hole (M center dot greater than or similar to 100 M-circle dot). Such a dark object could explain the large velocity dispersion of the four Trapezium stars observed in the ONC core. We further show that the putative massive black hole is likely to be a member of a binary system with approximate to 70% probability. In such a case, it could be detected either due to short periods of enhanced accretion of stellar winds from the secondary star during pericentre passages, or through a measurement of the motion of the secondary whose velocity would exceed 10 km s(-1) along the whole orbit
Population-based estimates of the prevalence of FMR1 expansion mutations in women with early menopause and primary ovarian insufficiency

Purpose: Primary ovarian insufficiency before the age of 40 years affects 1% of the female population and is characterized by permanent cessation of menstruation. Genetic causes include FMR1 expansion mutations. Previous studies have estimated mutation prevalence in clinical referrals for primary ovarian insufficiency, but these are likely to be biased as compared with cases in the general population. The prevalence of FMR1 expansion mutations in early menopause (between the ages of 40 and 45 years) has not been published. Methods: We studied FMR1 CGG repeat number in more than 2,000 women from the Breakthrough Generations Study who underwent menopause before the age of 46 years. We determined the prevalence of premutation (55-200 CGG repeats) and intermediate (45-54 CGG repeats) alleles in women with primary ovarian insufficiency (n = 254) and early menopause (n = 1,881). Results: The prevalence of the premutation was 2.0% in primary ovarian insufficiency, 0.7% in early menopause, and 0.4% in controls, corresponding to odds ratios of 5.4 (95% confidence interval - 1.7-17.4; P - 0.004) for primary ovarian insufficiency and 2.0 (95% confidence interval = 0.8-5.1; P = 0.12) for early menopause. Combining primary ovarian insufficiency and early menopause gave an odds ratio of 2.4 (95% confidence interval = 1.02-5.8; P = 0.04). Intermediate alleles were not significant risk factors for either early menopause or primary ovarian insufficiency. Conclusion: FMR1 premutations are not as prevalent in women with ovarian insufficiency as previous estimates have suggested, but they still represent a substantial cause of primary ovarian insufficiency and early menopause
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body and appendicular lean body mass measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide or suggestively genome wide. Replication in 63,475 individuals from 33 cohorts for whole body lean body mass and in 45,090 subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near _HSD17B11, VCAN, ADAMTSL3, IRS1,_ and _FTO_ for total lean body mass and for three single-nucleotide polymorphisms in/near _VCAN, ADAMTSL3, and IRS1_ for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass
Orthogonal polynomials from Hermitian matrices. II

This is the second part of the project "unified theory of classical orthogonal polynomials of a discrete variable derived from the eigenvalue problems of Hermitian matrices." In a previous paper, orthogonal polynomials having Jackson integral measures were not included, since such measures cannot be obtained from single infinite dimensional Hermitian matrices. Here we show that Jackson integral measures for the polynomials of the big q-Jacobi family are the consequence of the recovery of self-adjointness of the unbounded Jacobi matrices governing the difference equations of these polynomials. The recovery of self-adjointness is achieved in an extended \u272 Hilbert space on which a direct sum of two unbounded Jacobi matrices acts as a Hamiltonian or a difference Schrodinger operator for an infinite dimensional eigenvalue problem. The polynomial appearing in the upper/lower end of the Jackson integral constitutes the eigenvector of each of the two-unbounded Jacobi matrix of the direct sum. We also point out that the orthogonal vectors involving the q-Meixner (q-Charlier) polynomials do not form a complete basis of the \u272 Hilbert space, based on the fact that the dual q-Meixner polynomials introduced in a previous paper fail to satisfy the orthogonality relation. The complete set of eigenvectors involving the q-Meixner polynomials is obtained by constructing the duals of the dual q-Meixner polynomials which require the two-component Hamiltonian formulation. An alternative solution method based on the closure relation, the Heisenberg operator solution, is applied to the polynomials of the big q-Jacobi family and their duals and q-Meixner (q-Charlier) polynomials. Published by AIP Publishing
Spectral flow and conformal blocks in AdS3

In this article we investigate the structure of the four-point functions of the
AdS3-WZNW model. We consider the integral expression for the unflowed four-point correlator involving at least one state in the discrete part of the spectrum derived by analytic continuation from the H+3 -WZNW model and we show that the conformal blocks can be obtained from those with an extremal-weight state by means of an intertwining operator. We adapt the procedure for dealing with correlators with a single unit of spectral flow charge and we get a factorized integral expression for the corresponding four-point function. We finally transform the formulas back to the space-time picture.Fil: Cagnacci, Yago Javier. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Iguri, Sergio Manuel. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; Argentin