pinecone/core-2020-05-10-deduplication huggingface dataset:
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.

This is an open access article under the CC BY-NC-ND licenseInflammatory response induced by microglia plays aÂ critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is known about endogenous ligands that trigger TLR4 activation. Here, we report that galectin-3 (Gal3) released by microglia acts as an endogenous paracrine TLR4 ligand. Gal3-TLR4 interaction was further confirmed in a murine neuroinflammatory model (intranigral lipopolysaccharide [LPS] injection) and in human stroke subjects. Depletion of Gal3 exerted neuroprotective and anti-inflammatory effects following global brain ischemia and in the neuroinflammatory LPS model. These results suggest that Gal3-dependent-TLR4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain
Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InÂ Vivo.

Breaching endothelial cells (ECs) is a decisive step in the migration of leukocytes from the vascular lumen to the extravascular tissue, but fundamental aspects of this response remain largely unknown. We have previously shown that neutrophils can exhibit abluminal-to-luminal migration through EC junctions within mouse cremasteric venules and that this response is elicited following reduced expression and/or functionality of the EC junctional adhesion molecule-C (JAM-C). Here we demonstrate that the lipid chemoattractant leukotriene B4 (LTB4) was efficacious at causing loss of venular JAM-C and promoting neutrophil reverse transendothelial cell migration (rTEM) inÂ vivo. Local proteolytic cleavage of EC JAM-C by neutrophil elastase (NE) drove this cascade of events as supported by presentation of NE to JAM-C via the neutrophil adhesion molecule Mac-1. The results identify local LTB4-NE axis as a promoter of neutrophil rTEM and provide evidence that this pathway can propagate a local sterile inflammatory response to become systemic
Performance of sediment transport simulations on NVIDIA’s Kepler architecture

Aiming to understand how high-performance CUDA programming can be done for NVIDIA's new Kepler architecture, we have investigated a specific case of simulating sediment transport. The arisen stencil computations have distinct features connected to the two nonlinear partial differential equations that constitute the mathematical model. Consequently, the required CUDA programming effort differs for the two corresponding CUDA kernel functions. While Kepler's new read-only data cache brings enough benefits for one kernel function, performance of the other kernel function is further enhanceable through using the shared memory and so-called halo threads. The highest achieved performance of the stencil computation amounts to 190.45 GFLOPs on a Tesla K20 GPU
Ethnographies of austerity : temporality, crisis and affect in Southern Europe

This article focuses on how the economic crisis in Southern Europe has stimulated temporal thought (temporality), whether tilted in the direction of historicizing, presentifying, or futural thought, provoking people to rethink their relationship to time. The argument is developed with particular reference to the ethnographies of living with austerity inside the eurozone contained in this special issue. The studies identify the ways the past may be activated, lived, embodied, and re-fashioned under contracting economic horizons. We argue for the empirical study of crisis that captures the decisions or non-decisions that people make, and the actual temporal processes by which they judge responses. We conclude that modern linear historicism is often overridden in such moments by other historicities, showing that in crises, not only time, but history itself as an organizing structure and set of expectations, is up for grabs.Publisher PDFPeer reviewe
Population types of cataclysmic variables in the solar neighbourhood

The Galactic orbital parameters of 159 cataclysmic variables in the Solar neighbourhood are calculated, for the first time, to determine their population types using published kinematical parameters. Population analysis shows that about 6% of cataclysmic variables in the sample are members of the thick disc component of the Galaxy. This value is consistent with the fraction obtained from star count analysis. The rest of the systems in the sample are found to be in the thin disc component of the Galaxy. Our analysis revealed no halo CVs in the Solar vicinity. About 60% of the thick disc CVs have orbital periods below the orbital period gap. This result is roughly consistent with the predictions of population synthesis models developed for cataclysmic variables. A kinematical age of 13 Gyr is obtained using total space velocity dispersion of the most probable thick disc CVs which is consistent with the age of thick disc component of the Galaxy
Gaia FGK benchmark stars: abundances of α and iron-peak elements

Context. In the current era of large spectroscopic surveys of the Milky Way, reference stars for calibrating astrophysical parameters and chemical abundances are of paramount importance. Aims. We determine elemental abundances of Mg, Si, Ca, Sc, Ti, V, Cr, Mn, Co, and Ni for our predefined set of Gaia FGK benchmark stars. Methods. By analysing high-resolution spectra with a high signal-to-noise ratio taken from several archive datasets, we combined results of eight different methods to determine abundances on a line-by-line basis. We performed a detailed homogeneous analysis of the systematic uncertainties, such as differential versus absolute abundance analysis. We also assessed errors that are due to non-local thermal equilibrium and the stellar parameters in our final abundances. Results. Our results are provided by listing final abundances and the different sources of uncertainties, as well as line-by-line and method-by-method abundances. Conclusions. The atmospheric parameters of the Gaia FGK benchmark stars are already being widely used for calibration of several pipelines that are applied to different surveys. With the added reference abundances of ten elements, this set is very suitable for calibrating the chemical abundances obtained by these pipelines
On the robustness of the q-Gaussian family

We introduce three deformations, called α-, β-, and γ deformation respectively, of a N-body probabilistic model, first proposed by Rodriguez et al. (2008), having q-Gaussians as N → ∞ limiting probability distributions. The proposed α- and β-deformations are asymptotically scale-invariant, whereas the γ-deformation is not. We prove that, for both α- and β-deformations, the resulting deformed triangles still have q-Gaussians as limiting distributions, with a value of q independent (dependent) on the deformation parameter in the α-case (β- case). In contrast, the γ-case, where we have used the celebrated Q-numbers and the Gauss binomial coefficients, yields other limiting probability distribution functions, outside the q-Gaussian family. These results suggest that scale-invariance might play an important role regarding the robustness of the q-Gaussian family
Observation of a peaking structure in the J/psi phi mass spectrum from B(+/-) to J/psi phi K(+/-) decays

A peaking structure in the J/psi phi mass spectrum near threshold is observed in B(+/-) to J/psi phi K(+/-) decays, produced in pp collisions at sqrt(s) = 7 TeV collected with the CMS detector at the LHC. The data sample, selected on the basis of the dimuon decay mode of the J/psi, corresponds to an integrated luminosity of 5.2 inverse femtobarns. Fitting the structure to an S-wave relativistic Breit-Wigner lineshape above a three-body phase-space nonresonant component gives a signal statistical significance exceeding five standard deviations. The fitted mass and width values are m = 4148.0 +- 2.4 (stat.) +- 6.3 (syst.) MeV and Gamma = 28 +15 -11 (stat.) +- 19 (syst.) MeV, respectively. Evidence for an additional peaking structure at higher J/psi phi mass is also reported
Feasibility of top quark measurements at LHCb and constraints on the large- x gluon PDF

The forward LHCb acceptance opens interesting possibilities of studying precision Standard Model hard processes in a kinematical region beyond the reach of ATLAS and CMS. In this paper we perform a feasibility study for cross-section measurements of top quark pairs with the LHCb detector, with an analysis of signal and background rates for selected final states, and determine the potential precision achievable at $ \sqrt{s} $ = 7 and 14 TeV. We then study the dependence of theoretical uncertainties on the pseudorapidity distribution of top quarks produced in pair production at NLO, and observe that a cross-section measurement at high pseudorapidity has enhanced sensitivity to probe the high- x gluon PDF as compared to measurements in the central-region. Based on simulated pseudodata, the impact of a 14 TeV cross-section measurement on the gluon PDF and charge asymmetry is quantified
Thresholds of large N factorization in CFT 4 : exploring bulk spacetime in AdS 5

Large N factorization ensures that, for low-dimension gauge-invariant operators in the half-BPS sector of N = 4 $$ \mathcal{N}=4 $$ SYM, products of holomorphic traces have vanishing correlators with single anti-holomorphic traces. This vanishing is necessary to consistently map trace operators in the CFT 4 to a Fock space of graviton oscillations in the dual AdS 5 . We investigate the regimes at which the CFT correlators do not vanish but become of order one in the large N limit, which we call a factorization threshold . Quite generally, we find the threshold to be when the product of the two holomorphic operator dimensions is of order N log N . Our analysis considers extremal and non-extremal correlators and correlators in states dual to LLM backgrounds, and we observe intriguing similarities between the the energy-dependent running coupling of non-abelian gauge theories and our threshold equations. Finally, we discuss some interpretations of the threshold within the bulk AdS spacetime
P -wave resonant state of the HeΣ4 hypernucleus in the He4(K−,π−) reaction

We theoretically investigate a possible existence of a p -wave HeΣ4 resonant state with Jπ=1− , T≃1/2 above the Σ threshold, using a coupled (3N–Λ)+(3N–Σ) model with a spreading potential. We calculate inclusive and Σ – Λ conversion π− spectra in a He4(K−,π−) reaction at 1.5 GeV/ c , θlab=4–12° by the Green's function method in a distorted-wave impulse approximation. The pole position for the p -wave Σ resonant state in HeΣ4 is determined on the Riemann sheets in the complex E plane. The result shows that a peak of the HeΣ4 resonant state is clearly obtained in the conversion spectra above the Σ threshold, and that the angular distributions of these spectra enable extraction of the contribution of the resonant state from the π− spectra. Effects of the Σ -nucleus potential and the interference between Λ and Σ on the spectra are also discussed
GUT-inspired SUSY and the muon g − 2 anomaly: prospects for LHC 14 TeV

We consider the possibility that the muon g − 2 anomaly, δ ( g − 2) μ , finds its origins in low energy supersymmetry (SUSY). In the general MSSM the parameter space consistent with δ ( g − 2) μ and correct dark matter relic density of the lightest neutralino easily evades the present direct LHC limits on sparticle masses and also lies to a large extent beyond future LHC sensitivity. The situation is quite different in GUT-defined scenarios where input SUSY parameters are no longer independent. We analyze to what extent the LHC can probe a broad class of GUT-inspired SUSY models with gaugino non-universality that are currently in agreement with the bounds from δ ( g − 2) μ , as well as with the relic density and the Higgs mass measurement. To this end we perform a detailed numerical simulation of several searches for electroweakino and slepton production at the LHC and derive projections for the LHC 14 TeV run. We show that, within GUT-scale SUSY there is still plenty of room for the explanation of the muon anomaly, although the current LHC data already imply strong limits on the parameter space consistent with δ ( g − 2) μ . On the other hand, we demonstrate that the parameter space will be basically fully explored within the sensitivity of the 14 TeV run with 300 fb −1 . This opens up the interesting possibility that, if the ( g − 2) μ anomaly is real then some positive signals must be detected at the LHC, or else these models will be essentially ruled out. Finally, we identify the few surviving spectra that will provide a challenge for detection at the LHC 14 TeV run and we characterize their properties
The SO(2r)2 string functions as q -diagrams

We discuss our conjecture for simply laced Lie algebras level two string functions of mark one fundamental weights and prove it for the SO(2r) algebra. To prove our conjecture we introduce q -diagrams and examine the diagrammatic interpretations of known identities by Euler, Cauchy, Heine, Jacobi and Ramanujan. Interestingly, the diagrammatic approach implies these identities are related in the sense that they represent the first few terms in an infinite series of diagrammatic identities. Furthermore, these diagrammatic identities entail all the identities needed to prove our conjecture as well as generalise it to all SO(2r) level two string functions. As such, our main objective is proving these series of diagrammatic identities thus extending the works mentioned and establishing our conjecture for the SO(2r) level two string functions
Predicting positive parity Bs mesons from lattice QCD

We determine the spectrum of Bs 1P states using lattice QCD. For the Bs1(5830) and Bs2⁎(5840) mesons, the results are in good agreement with the experimental values. Two further mesons are expected in the quantum channels JP=0+ and 1+ near the BK and B⁎K thresholds. A combination of quark–antiquark and B(⁎) meson–Kaon interpolating fields are used to determine the mass of two QCD bound states below the B(⁎)K threshold, with the assumption that mixing with Bs(⁎)η and isospin-violating decays to Bs(⁎)π are negligible. We predict a JP=0+ bound state Bs0 with mass mBs0=5.711(13)(19) GeV . With further assumptions motivated theoretically by the heavy quark limit, a bound state with mBs1=5.750(17)(19) GeV is predicted in the JP=1+ channel. The results from our first principles calculation are compared to previous model-based estimates
Efeitos da redução no consumo de cafeína sobre a percepção do zumbido

INTRODUCTION:For many years, excessive caffeine consumption has been touted as an aggravating factor for tinnitus. The pathophysiology behind this effect is probably related to the blockage of adenosine receptors by the action of caffeine on the central nervous system.OBJECTIVE:To evaluate the effects of reduction of coffee consumption on tinnitus sensation and to identify subgroups more prone to benefit from this therapeutic strategy. Study design: prospective.METHODS:Twenty-six tinnitus patients who consumed at least 150 mL of coffee per day were selected. All were asked to reduce their coffee consumption. The Tinnitus Handicap Inventory (THI) questionnaire was completed by the patients before and after the reduction of coffee consumption, as well as a visual-analogue scale (VAS) graduated from 1 to 10.RESULTS:THI and VAS scores were significantly reduced (p < 0.05). In the subgroups less than 60 years old, bilateral tinnitus and daily coffee consumption between 150 and 300 mL showed a significantly greater reduction of THI and VAS scores.CONCLUSION:Patients under 60 years of age with bilateral tinnitus and daily coffee consumption between 150 and 300 mL are more prone to benefit from consumption reduction. Thirty-day observation periods may be helpful for a better therapeutical decision.INTRODUÇÃO:O consumo abusivo de cafeína vem sendo descrito como fator de piora e causa do zumbido há muitos anos. A fisiopatologia deste efeito está provavelmente relacionada ao bloqueio dos receptores inibitórios adenosínicos pela cafeína no sistema nervoso central.OBJETIVO:Avaliar os efeitos da redução do consumo de cafeína na percepção do zumbido e identificar subgrupos de pacientes mais propensos a benefícios com esta proposta. Tipo de estudo: prospectivo.MÉTODO:Selecionados 26 pacientes com zumbido neurossensorial e consumo diário superior a 150 mL de café. Os efeitos da redução do consumo foram avaliados através do Tinnitus Handicap Inventory (THI) e da escala visual-análoga (EVA).RESULTADOS:Houve redução estatisticamente significativa (p < 0,05) nos escores do THI e EVA. Nos subgrupos com idade inferior a 60 anos, zumbido bilateral e consumo diário de café entre 150 e 300 mL apresentaram maior redução dos escores THI e EVA.CONCLUSÃO:Em pacientes com idade inferior a 60 anos, zumbido bilateral e consumo diário de café entre 150 e 300 mL apresentaram benefícios com a redução no consumo diário de cafeína. Períodos observacionais de 30 dias podem ser úteis para a decisão terapêutica.Universidade Federal de São Paulo (UNIFESP)Faculdade de Medicina de ValençaTinnitus Research InitiativeUniversidade Federal de Minas GeraisCentro de Tratamento e Pesquisa em ZumbidoOtorrinolaringologia Sul-FluminenseSanta Casa de Misericórdia de Belo HorizonteUNIFESPSciEL
Search for pair and single production of new heavy quarks that decay to a Z boson and a third-generation quark in ppcollisions at s√=8 TeV with the ATLAS detector

A search is presented for the production of new heavy quarks that decay to a Z boson and a third-generation Standard Model quark. In the case of a new charge +2/3 quark (T), the decay targeted is T -&gt; Zt, while the decay targeted for a new charge -1/3 quark (B) is B -&gt; Zb. The search is performed with a dataset corresponding to 20.3 fb(-1) of p p collisions at root s = 8TeV recorded in 2012 with the ATLAS detector at the CERN Large Hadron Collider. Selected events contain a high transverse momentum Z boson candidate reconstructed from a pair of oppositely charged same-flavor leptons (electrons or muons), and are analyzed in two channels defined by the absence or presence of a third lepton. Hadronic jets, in particular those with properties consistent with the decay of a b-hadron, are also required to be present in selected events. Different requirements are made on the jet activity in the event in order to enhance the sensitivity to either heavy quark pair production mediated by the strong interaction, or single production mediated by the electroweak interaction. No significant excess of events above the Standard Model expectation is observed, and lower limits are derived on the mass of vector-like T and B quarks under various branching ratio hypotheses, as well as upper limits on the magnitude of electroweak coupling parameters.<p>ATLAS Collaboration, for complete list of authors see http://dx.doi.org/10.1007/JHEP11(2014)104</p
Search for new phenomena with photon plus jet events in proton-proton collisions at TeV with the ATLAS detector

A search is performed for the production of high-mass resonances decaying into a photon and a jet in 3.2 fb(-1) of proton-proton collisions at a centre-of-mass energy of TeV collected by the ATLAS detector at the Large Hadron Collider. Selected events have an isolated photon and a jet, each with transverse momentum above 150 GeV. No significant deviation of the gamma+jet invariant mass distribution from the background-only hypothesis is found. Limits are set at 95% confidence level on the cross sections of generic Gaussian-shaped signals and of a few benchmark phenomena beyond the Standard Model: excited quarks with vector-like couplings to the Standard Model particles, and non-thermal quantum black holes in two models of extra spatial dimensions. The minimum excluded visible cross sections for Gaussian-shaped resonances with width-to-mass ratios of 2% decrease from about 6 fb for a mass of 1.5 TeV to about 0.8 fb for a mass of 5 TeV. The minimum excluded visible cross sections for Gaussian-shaped resonances with width-to-mass ratios of 15% decrease from about 50 fb for a mass of 1.5 TeV to about 1.0 fb for a mass of 5 TeV. Excited quarks are excluded below masses of 4.4 TeV, and non-thermal quantum black holes are excluded below masses of 3.8 (6.2) TeV for Randall-Sundrum (Arkani-Hamed-Dimopoulous-Dvali) models with one (six) extra dimensions.<p>ATLAS Collaboration, for complete list of authors see http://dx.doi.org/10.1007/JHEP03(2016)041</p><p>Funding: We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; IN2P3-CNRS, CEADSM/IRFU, France; GNSF, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, the Canada Council, CANARIE, CRC, Compute Canada, FQRNT, and the Ontario Innovation Trust, Canada; EPLANET, ERC, FP7, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex and Idex, ANR, Region Auvergne and Fondation Partager le Savoir, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF; BSF, GIF and Minerva, Israel; BRF, Norway; the Royal Society and Leverhulme Trust, United Kingdom.</p
Viral cell-to-cell movement requires formation of cortical punctate structures containing Red clover necrotic mosaic virus movement protein.

Movement protein (MP) of Red clover necrotic mosaic virus (RCNMV) forms punctate structures on the cortical endoplasmic reticulum (ER) of Nicotiana benthamiana cells, which are associated with viral RNA1 replication (Kaido et al., Virology 395, 232-242. 2009). We investigated the significance of ER-targeting by MP during virus movement from cell to cell, by analyzing the function of a series of MPs with varying length deletions at their C-terminus, either fused or not fused with green fluorescent protein (GFP). The C-terminal 70 amino acids were crucial to ER-localization of MP-GFP and cell-to-cell movement of the recombinant virus encoding it. However, C-terminal deletion did not affect MP functions, such as increasing the size exclusion limit of plasmodesmata, single-stranded RNA binding in vitro, and MP interacting in vivo. We discuss the possible role of this MP region in virus movement from cell to cell