pinecone/core-2020-05-10-deduplication huggingface dataset:
“Eating addiction”, rather than “food addiction”, better captures addictive-like eating behavior

Abstract“Food addiction” has become a focus of interest for researchers attempting to explain certain processes and/or behaviors that may contribute to the development of obesity. Although the scientific discussion on “food addiction” is in its nascent stage, it has potentially important implications for treatment and prevention strategies. As such, it is important to critically reflect on the appropriateness of the term “food addiction”, which combines the concepts of “substance-based” and behavioral addiction. The currently available evidence for a substance-based food addiction is poor, partly because systematic clinical and translational studies are still at an early stage. We do however view both animal and existing human data as consistent with the existence of addictive eating behavior. Accordingly, we stress that similar to other behaviors eating can become an addiction in thus predisposed individuals under specific environmental circumstances. Here, we introduce current diagnostic and neurobiological concepts of substance-related and non-substance-related addictive disorders, and highlight the similarities and dissimilarities between addiction and overeating. We conclude that “food addiction” is a misnomer because of the ambiguous connotation of a substance-related phenomenon. We instead propose the term “eating addiction” to underscore the behavioral addiction to eating; future research should attempt to define the diagnostic criteria for an eating addiction, for which DSM-5 now offers an umbrella via the introduction on Non-Substance-Related Disorders within the category Substance-Related and Addictive Disorders
Search for heavy Majorana neutrinos in μ±μ±+jets and e±e±+jets events in pp collisions at s=7 TeV

AbstractA search is performed for heavy Majorana neutrinos (N) using an event signature defined by two same-sign charged leptons of the same flavour and two jets. The data correspond to an integrated luminosity of 4.98 fb−1 of pp collisions at a centre-of-mass energy of 7 TeV collected with the CMS detector at the Large Hadron Collider. No excess of events is observed beyond the expected standard model background and therefore upper limits are set on the square of the mixing parameter, |VℓN|2, for ℓ=e,μ, as a function of heavy Majorana-neutrino mass. These are the first direct upper limits on the heavy Majorana-neutrino mixing for mN>90 GeV
Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature

AbstractEpisodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder characterized by myokymia and attacks of ataxic gait often precipitated by stress. Several genetic mutations have been identified in the Shaker-like K+ channel Kv1.1 (KCNA1) of EA1 individuals, including V408A, which result in remarkable channel dysfunction. By inserting the heterozygous V408A, mutation in one Kv1.1 allele, a mouse model of EA1 has been generated (Kv1.1V408A/+). Here, we investigated the neuromuscular transmission of Kv1.1V408A/+ ataxic mice and their susceptibility to physiologically relevant stressors. By using in vivo preparations of lateral gastrocnemius (LG) nerve–muscle from Kv1.1+/+ and Kv1.1V408A/+ mice, we show that the mutant animals exhibit spontaneous myokymic discharges consisting of repeated singlets, duplets or multiplets, despite motor nerve axotomy. Two-photon laser scanning microscopy from the motor nerve, ex vivo, revealed spontaneous Ca2+ signals that occurred abnormally only in preparations dissected from Kv1.1V408A/+ mice. Spontaneous bursting activity, as well as that evoked by sciatic nerve stimulation, was exacerbated by muscle fatigue, ischemia and low temperatures. These stressors also increased the amplitude of compound muscle action potential. Such abnormal neuromuscular transmission did not alter fiber type composition, neuromuscular junction and vascularization of LG muscle, analyzed by light and electron microscopy. Taken together these findings provide direct evidence that identifies the motor nerve as an important generator of myokymic activity, that dysfunction of Kv1.1 channels alters Ca2+ homeostasis in motor axons, and also strongly suggest that muscle fatigue contributes more than PNS fatigue to exacerbate the myokymia/neuromyotonia phenotype. More broadly, this study points out that juxtaparanodal K+ channels composed of Kv1.1 subunits exert an important role in dampening the excitability of motor nerve axons during fatigue or ischemic insult
Remobilisation features and structural control on ore grade distribution at the Konkola stratiform Cu–Co ore deposit, Zambia

AbstractThe Konkola deposit is a high grade stratiform Cu–Co ore deposit in the Central African Copperbelt in Zambia. Economic mineralisation is confined to the Ore Shale formation, part of the Neoproterozoic metasedimentary rocks of the Katanga Supergroup. Petrographic study reveals that the copper–cobalt ore minerals are disseminated within the host rock, sometimes concentrated along bedding planes, often associated with dolomitic bands or clustered in cemented lenses and in layer-parallel and irregular veins. The hypogene sulphide mineralogy consists predominantly of chalcopyrite, bornite and chalcocite. Based upon relationships with metamorphic biotite, vein sulphides and most of the sulphides in cemented lenses were precipitated during or after biotite zone greenschist facies metamorphism. New δ34S values of sulphides from the Konkola deposit are presented. The sulphur isotope values range from −8.7‰ to +1.4‰ V-CDT for chalcopyrite from all mineralising phases and from −4.4‰ to +2.0‰ V-CDT for secondary chalcocite. Similarities in δ34S for sulphides from different vein generations, earlier sulphides and secondary chalcocite can be explained by (re)mobilisation of S from earlier formed sulphide phases, an interpretation strongly supported by the petrographic evidence. Deep supergene enrichment and leaching occurs up to a km in depth, predominantly in the form of secondary chalcocite, goethite and malachite and is often associated with zones of high permeability. Detailed distribution maps of total copper and total cobalt contents of the Ore Shale formation show a close relationship between structural features and higher copper and lower cobalt contents, relative to other areas of the mine. Structural features include the Kirilabombwe anticline and fault zones along the axial plane and two fault zones in the southern limb of the anticline. Cobalt and copper behave differently in relation to these structural features. These structures are interpreted to have played a significant role in (re)mobilisation and concentration of the metals, in agreement with observations made elsewhere in the Zambian Copperbelt
Borel–Smith functions and the Dade group

AbstractWe show that there is an exact sequence of biset functors over p-groups0→Cb→jB∗→ΨDΩ→0 where Cb is the biset functor for the group of Borel–Smith functions, B∗ is the dual of the Burnside ring functor, DΩ is the functor for the subgroup of the Dade group generated by relative syzygies, and the natural transformation Ψ is the transformation recently introduced by the first author in [S. Bouc, A remark on the Dade group and the Burnside group, J. Algebra 279 (2004) 180–190]. We also show that the kernel of mod 2 reduction of Ψ is naturally equivalent to the functor B× of units of the Burnside ring and obtain exact sequences involving the torsion part of DΩ, mod 2 reduction of Cb, and B×
Nucleon effective E-mass in neutron-rich matter from the Migdal–Luttinger jump

AbstractThe well-known Migdal–Luttinger theorem states that the jump of the single-nucleon momentum distribution at the Fermi surface is equal to the inverse of the nucleon effective E-mass. Recent experiments studying short-range correlations (SRC) in nuclei using electron–nucleus scatterings at the Jefferson National Laboratory (JLAB) together with model calculations constrained significantly the Migdal–Luttinger jump at saturation density of nuclear matter. We show that the corresponding nucleon effective E-mass is consequently constrained to M0⁎,E/M≈2.22±0.35 in symmetric nuclear matter (SNM) and the E-mass of neutrons is smaller than that of protons in neutron-rich matter. Moreover, the average depletion of the nucleon Fermi sea increases (decreases) approximately linearly with the isospin asymmetry δ according to κp/n≈0.21±0.06±(0.19±0.08)δ for protons (neutrons). These results will help improve our knowledge about the space–time non-locality of the single-nucleon potential in neutron-rich nucleonic matter useful in both nuclear physics and astrophysics
Can the pomeron be derived from a Euclidean–Minkowskian duality?

AbstractAfter a brief review, in the first part, of some relevant analyticity and crossing-symmetry properties of the correlation functions of two Wilson loops in QCD, when going from Euclidean to Minkowskian theory, in the second part we shall see how these properties can be related to the still unsolved problem of the asymptotic s-dependence of the hadron–hadron total cross sections. In particular, we critically discuss the question if (and how) a pomeron-like behaviour can be derived from this Euclidean–Minkowskian duality
Renormalization of 1S0 NN scattering amplitude in effective field theory

AbstractCutoff regularized subleading order 1S0 NN potential of effective field theory (EFT) is iterated using Lippmann–Schwinger equation. It is shown that the scattering amplitudes calculated in cutoff and subtractively renormalized EFT are equal up to the accuracy of performed calculations. Non-perturbative renormalization, where part of divergencies are absorbed into two contact interaction coupling constants with subsequent removal of regularization is also performed. Cutoff and dimensional regularizations both lead to finite but different results within this scheme
Search for a Higgs boson in the diphoton final state using the full CDF data set from pp¯ collisions at s=1.96 TeV

AbstractA search for a narrow Higgs boson resonance in the diphoton mass spectrum is presented based on data corresponding to 10 fb−1 of integrated luminosity collected by the CDF experiment from proton–antiproton collisions at s=1.96 TeV. To increase the sensitivity of the search, we employ a multivariate discriminant technique for the first time in this channel at CDF. No evidence of signal is observed, and upper limits are set on the cross section times branching ratio of the resonant state as a function of the Higgs boson mass. The limits are interpreted in the context of the standard model with an expected (observed) limit on the cross section times branching ratio of 9.9 (17.0) times the standard model prediction at the 95% credibility level for a Higgs boson mass of 125 GeV/c2. Moreover, a Higgs boson with suppressed couplings to fermions is excluded for masses below 114 GeV/c2 at the 95% credibility level
Direct determination of ground-state transition widths of low-lying dipole states in 140Ce with the self-absorption technique

AbstractThe technique of self absorption has been applied for the first time to study the decay pattern of low-lying dipole states of 140Ce. In particular, ground-state transition widths Γ0 and branching ratios Γ0Γ to the ground state have been investigated in the energy domain of the pygmy dipole resonance. Relative self-absorption measurements allow for a model-independent determination of Γ0. Without the need to perform a full spectroscopy of all decay channels, also the branching ratio to the ground state can be determined. The experiment on 140Ce was conducted at the bremsstrahlung facility of the superconducting Darmstadt electron linear accelerator S-DALINAC. In total, the self-absorption and, thus, Γ0 were determined for 104 excited states of 140Ce. The obtained results are presented and discussed with respect to simulations of γ cascades using the DICEBOX code
FKBP12.6 Activates RyR1: Investigating the Amino Acid Residues Critical for Channel Modulation

AbstractWe have previously shown that FKBP12 associates with RyR2 in cardiac muscle and that it modulates RyR2 function differently to FKBP12.6. We now investigate how these proteins affect the single-channel behavior of RyR1 derived from rabbit skeletal muscle. Our results show that FKBP12.6 activates and FKBP12 inhibits RyR1. It is likely that both proteins compete for the same binding sites on RyR1 because channels that are preactivated by FKBP12.6 cannot be subsequently inhibited by FKBP12. We produced a mutant FKBP12 molecule (FKBP12E31Q/D32N/W59F) where the residues Glu31, Asp32, and Trp59 were converted to the corresponding residues in FKBP12.6. With respect to the functional regulation of RyR1 and RyR2, the FKBP12E31Q/D32N/W59F mutant lost all ability to behave like FKBP12 and instead behaved like FKBP12.6. FKBP12E31Q/D32N/W59F activated RyR1 but was not capable of activating RyR2. In conclusion, FKBP12.6 activates RyR1, whereas FKBP12 activates RyR2 and this selective activator phenotype is determined within the amino acid residues Glu31, Asp32, and Trp59 in FKBP12 and Gln31, Asn32, and Phe59 in FKBP12.6. The opposing but different effects of FKBP12 and FKBP12.6 on RyR1 and RyR2 channel gating provide scope for diversity of regulation in different tissues
Management of Acute Myocardial Infarction in Patients With Dementia: Data From SveDem, the Swedish Dementia Registry

AbstractObjectivesWe aimed to (1) study factors that determine the use of invasive procedures in the management of acute myocardial infarction (AMI) in patients with dementia and (2) determine whether the use of invasive procedures was associated with their better survival.DesignCohort study based on patients registered in the Swedish Dementia Registry (SveDem), 2007–2012. Median follow-up time was 228 days.SettingPatients diagnosed with dementia in specialist memory clinics and primary care units in Sweden.ParticipantsA total of 525 patients with dementia who suffered AMI (mean age 89 years, 54% women).MeasurementsInformation on AMI and use of invasive procedures (coronary angiography and percutaneous coronary intervention) was obtained from Swedish national health registers. Binary logistic regression was applied to study associations of patients’ characteristics with the use of invasive procedures; odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Survival was analyzed with Kaplan-Meier curves; log-rank test was used to compare survival of patients who received an invasive procedure versus those who did not receive it. Cox regression was applied to study association of the invasive procedures with all-cause mortality; hazard ratios (HRs) with 95% CIs were calculated.ResultsOne hundred ten patients (21%) with dementia received an invasive procedure in the management of AMI. After multivariate adjustment, lower age and higher global cognitive status were associated with the use of invasive procedures. The invasively managed patients survived longer (P = .001). The use of invasive procedures was associated with a lower risk of all-cause mortality, adjusting for type of AMI and dementia disorder, age, gender, registration unit, history of AMI and comorbidity score (HR 0.35, 95% CI 0.21–0.59), or total number of drugs (HR 0.34, 95% CI 0.20–0.58).ConclusionAge and cognitive status determine the use of invasive procedures in patients with dementia. This study suggests that the invasive management of AMI has a benefit for survival of patients with dementia
Modelling Cavity Ventilation Behind Brick Veneer Cladding: How Reliable are the Common Assumptions?

AbstractThroughout the years, different numerical HAM-simulation tools have been developed to assess and predict the heat, air and moisture response of building components. But, though commercially available and commonly applied in building practice, still, several simplifications and shortcomings exist in the common models. Probably the most important one, is the fact that most tools neglect or strongly simplify air transport, focusing only on heat and moisture transport. Especially for the analysis of wood frame constructions, these simplified models may cause a large discrepancy between simulation results and real performance. This study aims at a comparison of the outcomes of numerical HAM-simulations for wood frame constructions with experimental data of real test cases. In particular, the focus of this paper is on cavity ventilation behind brick veneer. Therefore, a simplified version of a wood frame wall with brick veneer cladding is studied in this paper. Different common modelling assumptions are compared. Furthermore, a detailed measuring campaign has been conducted at the VLIET test building of the KU Leuven to validate the different modelling approaches. By verifying the results of the numerical simulations by the data of real test cases, the reliability of the modelling assumptions can be analysed. The results of this study clearly show that simplified assumptions on cavity ventilation in HAM-models might cause large discrepancies between simulation results and in-situ measurements
Training response inhibition to reduce food consumption: Mechanisms, stimulus specificity and appropriate training protocols

AbstractTraining individuals to inhibit their responses towards unhealthy foods has been shown to reduce food intake relative to a control group. Here we aimed to further explore these effects by investigating the role of stimulus devaluation, training protocol, and choice of control group. Restrained eaters received either inhibition or control training using a modified version of either the stop-signal or go/no-go task. Following training we measured implicit attitudes towards food (Study 1) and food consumption (Studies 1 and 2). In Study 1 we used a modified stop-signal training task with increased demands on top-down control (using a tracking procedure and feedback to maintain competition between the stop and go processes). With this task, we found no evidence for an effect of training on implicit attitudes or food consumption, with Bayesian inferential analyses revealing substantial evidence for the null hypothesis. In Study 2 we removed the feedback in the stop-signal training to increase the rate of successful inhibition and revealed a significant effect of both stop-signal and go/no-go training on food intake (compared to double-response and go training, respectively) with a greater difference in consumption in the go/no-go task, compared with the stop-signal task. However, results from an additional passive control group suggest that training effects could be partly caused by increased consumption in the go control group whereas evidence for reduced consumption in the inhibition groups was inconclusive. Our findings therefore support evidence that inhibition training tasks with higher rates of inhibition accuracy are more effective, but prompt caution for interpreting the efficacy of laboratory-based inhibition training as an intervention for behaviour change
Influence of bottom quark jet quenching on single electron tomography of Au + Au

AbstractHigh transverse momentum single (non-photonic) electrons are shown to be sensitive to the stopping power of both bottom, b, and charm, c, quarks in AA collisions. We apply the DGLV theory of radiative energy loss to predict c and b quark jet quenching and compare the FONLL and PYTHIA heavy flavor fragmentation and decay schemes. We show that single electrons in the pT=5–10GeV range are dominated by the decay of b quarks rather than the more strongly quenched c quarks in Au + Au collisions at s=200AGeV. The smaller b quark energy loss, even for extreme opacities with gluon rapidity densities up to 3500, is predicted to limit the nuclear modification factor, RAA, of single electrons to the range RAA∼0.5–0.6, in contrast to previous predictions of RAA≲0.2–0.3 based on taking only c quark jet fragmentation into account
Plasmacytoid Dendritic Cells Infiltrate the Skin in Positive Tuberculin Skin Test Indurations

Plasmacytoid dendritic cells (pDCs) are rarely present in normal skin but have been shown to infiltrate lesions of infections or autoimmune disorders. Here, we report that several DC subsets including CD123+ BDCA-2/CD303+ pDCs accumulate in the dermis in indurations induced by the tuberculin skin test (TST), used to screen immune sensitization by Mycobacterium tuberculosis. Although the purified protein derivate (PPD) used in the TST did not itself induce pDC recruitment or IFN-α production, the positive skin reactions showed high expression of the IFN-α-inducible protein MxA. In contrast, the local immune response to PPD was associated with substantial cell death and high expression of the cationic antimicrobial peptide LL37, which together can provide a means for pDC activation and IFN-α production. In vitro, pDCs showed low uptake of PPD compared with CD11c+ and BDCA-3/CD141+ myeloid DC subsets. Furthermore, supernatants from pDCs activated with LL37–DNA complexes reduced the high PPD uptake in myeloid DCs, as well as decreased their capacity to activate T-cell proliferation. Infiltrating pDCs in the TST reaction site may thus have a regulatory effect upon the antigen processing and presentation functions of surrounding potent myeloid DC subsets to limit potentially detrimental and excessive immune stimulation
High accuracy 235U(n,f) data in the resonance energy region

This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. C. Paradela, et al, ???High accuracy 235U(n,f) data in the resonance energy region???, EPJ Web of Conferences, Vol. 111, 2016, WONDER-2015 ??? 4TH International Workshop on Nuclear Data Evaluation for Reactor applications, 5 ??? 8 October 2015, Aix-en-Provence, France. Article available at https://www.epj-conferences.org/articles/epjconf/pdf/2016/06/epjconf_wonder2016_02003.pdf ?? Owned by the authors, published by EDP Sciences, 2016.The 235U neutron-induced cross section is widely used as reference cross section for measuring other fission cross sections, but in the resonance region it is not considered as an IAEA standard because of the scarce experimental data covering the full region. In this work, we deal with a new analysis of the experimental data obtained with a detection setup based on parallel plate ionization chambers (PPACs) at the CERN n-TOF facility in the range from 1 eV to 10 keV. The relative cross section has been normalised to the IAEA value in the region between 7.8 and 11 eV, which is claimed as well-known. Comparison with the ENDF/B-VII evaluation and the IAEA reference file from 100 eV to 10 keV are provided
High-order Hamiltonian splitting for the Vlasov–Poisson equations

We consider the Vlasov–Poisson equation in a Hamiltonian
framework and derive new time splitting methods based on the
decomposition of the Hamiltonian functional between the kinetic and
electric energy. Assuming smoothness of the solutions, we study the
order conditions of such methods. It appears that these conditions are
of Runge–Kutta–Nystr¨om type. In the one dimensional case, the order
conditions can be further simplified, and efficient methods of order 6
with a reduced number of stages can be constructed. In the general
case, high-order methods can also be constructed using explicit computations
of commutators. Numerical results are performed and show
the benefit of using high-order splitting schemes in that context. Complete
and self-contained proofs of convergence results and rigorous error
estimates are also given