pinecone/core-2020-05-10-deduplication huggingface dataset:
Interventions for nausea and vomiting in early pregnancy

Background\ud
Nausea, retching and vomiting are very commonly experienced by women in early pregnancy. There are considerable  physical and psychological effects on women who experience these symptoms. This is an update of a review of interventions for nausea and vomiting in early pregnancy previously published in 2003.\ud
Objectives\ud
To assess the effectiveness and safety of all interventions for nausea, vomiting and retching in early pregnancy, up to 20 weeks’ gestation.\ud
Search methods\ud
We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (28 May 2010).\ud
Selection criteria \ud
All randomised controlled trials of any intervention for nausea, vomiting and retching in early pregnancy. We excluded trials of interventions for hyperemesis gravidarum which are covered by another review. We also excluded quasi-randomised trials and trials using a crossover design.\ud
Data collection and analysis\ud
Four review authors, in pairs, reviewed the eligibility of trials and independently evaluated the risk of bias and extracted the data for included trials.\ud
Main results\ud
Twenty-seven trials, with 4041 women, met the inclusion criteria. These trials covered many interventions, including acupressure, acustimulation, acupuncture, ginger, vitamin B6 and several antiemetic drugs. We identified no studies of dietary or other lifestyle interventions. Evidence regarding the effectiveness of P6 acupressure, auricular (ear) acupressure and acustimulation of the P6 point was limited. Acupuncture (P6 or traditional) showed no significant benefit to women in pregnancy. The use of ginger products may be helpful to women, but the evidence of effectiveness was limited and not consistent. There was only limited evidence from trials to support the use of pharmacological agents including vitamin B6, and anti-emetic drugs to relieve mild or moderate nausea and vomiting. There was little information on maternal and fetal adverse outcomes and on psychological, social or economic outcomes. We were unable to pool findings from studies for most outcomes due to heterogeneity in study participants, interventions, comparison groups, and outcomes measured or reported. The methodological quality of the included studies was mixed.\ud
Authors’ conclusions \ud
Given the high prevalence of nausea and vomiting in early pregnancy, health professionals need to provide clear guidance to women, based on systematically reviewed evidence. There is a lack of high-quality evidence to support that advice. The difficulties in interpreting the results of the studies included in this review highlight the need for specific, consistent and clearly justified outcomes and approaches to measurement in research studies
Academic identities and communities of practice in a professional discipline

This is an Accepted Manuscript of an article published by Taylor & Francis in Teaching in Higher Education on 26 May 2009, available online: http://www.tandfonline.com/10.1080/13562510902898817.This paper explores the dynamics surrounding the formation of academic identities in a context where the nature of academic work is contested both as a result of tensions within the discipline and in response to pressure from both the institution and the field of higher education. It is based on a case study which investigated the process of academic identity formation at the micro level of a department at a South African university. The study revealed a complex relationship between identity construction and participation within the particular configuration of teaching, professional and research communities of practice that defined the academic field in the department. Multiple identity trajectories were evident, indicating the role of individual agency, despite the dominance of a professional community of practice within the department. The arrival of new academics in the department without professional practice experience was found to have created the possibility of a changed notion of the academic within the discipline
T-20 and T-1249 HIV fusion inhibitors' structure and conformation in solution: a molecular dynamics study

Fusion of the HIV envelope with the target cell membrane is a critical step of the HIV entry into the target cell. Several peptides based on the C-region of HIV gp41 have been used in clinical trials as possible HIV fusion inhibitors. Among these are T-1249 and T-20 (also known as enfurvitide). Despite recent works, a detailed molecular picture of the inhibitory mechanism of these molecules is still lacking. These peptides are usually depicted as alpha-helices by analogy with the structure of the sequence of the gp41 protein with which they are homologous. However, structures like these would be highly unstable in solution and thus would not explain, by themselves, the ability that the two fusion inhibitors have to become solvated by water and also interact effectively with cell membranes. To this effect, extensive molecular dynamics simulations were carried out to investigate the structure and conformational behavior of T-1249 and T-20 in water, as well as shorter homologous peptides CTP and 3f5, which show no inhibitory action. We found that the studied inhibitors have no stable structure in solution in the time scale studied. Additionally, the solvent accessible area varies significantly during the simulation. Our findings suggest that these peptides may assume not only one, but several possible sets of structures in solution, some of which more adequate to interact with the solvent, whereas others might be better suited to interact with cell membranes. Interestingly, and in accordance with published experimental studies, we verified that T-1249 displays considerably larger alpha-helical structure than T-20. Taking into account a recent study with design peptides with increased helicity, it is possible that this feature may be related to the increased inhibiting efficiency of T-1249 relative to that of T-20. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.http://dx.doi.org/10.1002/psc.98
Iterative determination of clinical beam phase space from dose measurements

Monte Carlo (MC) method can accurately compute the dose produced by medical linear accelerators. However, these calculations require a reliable description of the electron and/or photon beams delivering the dose, the phase space (PHSP), which is not usually available. A method to derive a phase space model from reference measurements that does not heavily rely on a detailed model of the accelerator head is presented. The iterative optimization process extracts the characteristics of the particle beams which best explains the reference dose measurements in water and air, given a set of constrain
Torsion Degrees of Freedom in the Regge Calculus as Dislocations on the Simplicial Lattice

Using the notion of a general conical defect, the Regge Calculus is generalized by allowing for dislocations on the simplicial lattice in addition to the usual disclinations. Since disclinations and dislocations correspond to curvature and torsion singularities, respectively, the method we propose provides a natural way of discretizing gravitational theories with torsion degrees of freedom like the Einstein-Cartan theory. A discrete version of the Einstein-Cartan action is given and field equations are derived, demanding stationarity of the action with respect to the discrete variables of the theory
Partition functions and the continuum limit in Penner matrix models

We present an implementation of the method of  orthogonal polynomials which is particularly suitable to study the partition functions of Penner random matrix models, to obtain their explicit forms in the exactly solvable cases, and to determine the coefficients of their perturbative expansions in the continuum limit. The method relies on identities satisfied by the resolvent of the Jacobi matrix in the three-term recursion relation of the associated families of orthogonal polynomials. These identities lead to a convenient formulation of the string equations. As an application, we show that in the continuum limit the free energy of certain exactly solvable models like the linear and double Penner models can be written as a sum of Gaussian contributions plus linear terms. To illustrate the one-cut case we discuss the linear, double and cubic Penner models, and for the two- cut case we discuss theoretically and numerically  the existence of a double-branch structure of the free energy for the Gaussian Penner model
Spatial and temporal variations of trace element distribution in soils and street dust of an industrial town in NW Spain: 15 years of study

Extensive spatial and temporal surveys, over 15 years, have been conducted in soil in urban parks and street dusts in one of the most polluted cities in western Europe, Avilés (NW Spain). The first survey was carried out in 1996, and since then monitoring has been undertaken every five years. Whilst the sampling site is a relatively small town, industrial activities (mainly the steel industry and Zn and Al metallurgy) and other less significant urban sources, such as traffic, strongly affect the load of heavy metals in the urban aerosol. Elemental tracers have been used to characterise the influence of these sources on the composition of soil and dust. Although PM10 has decreased over these years as a result of environmental measures undertaken in the city, some of the “industrial” elements still remain in concentrations of concern for example, up to 4.6% and 0.5% of Zn in dust and soil, respectively. Spatial trends in metals such as Zn and Cd clearly reflect sources from the processing industries. The concentrations of these elements across Europe have reduced over time, however the most recent results from Avilés revealed an upward trend in concentration for Zn, Cd, Hg and As. A risk assessment of the soil highlighted As as an element of concern since its cancer risk in adults was more than double the value above which regulatory agencies deem it to be unacceptable. If children were considered to be the receptors, then the risk nearly doubles from this element
LHC tests of light neutralino dark matter without light sfermions

We address the question how light the lightest MSSM neutralino can be as dark matter candidate in a scenario where all supersymmetric scalar particles are heavy. The hypothesis that the neutralino accounts for the observed dark matter density sets strong requirements on the supersymmetric spectrum, thus providing an handle for collider tests. In particular for a lightest neutralino below 100 GeV the relic density constraint translates into an upper bound on the Higgsino mass parameter μ in case all supersymmetric scalar particles are heavy. One can define a simplified model that highlights only the necessary features of the spectrum and their observable consequences at the LHC. Reinterpreting recent searches at the LHC we derive limits on the mass of the lightest neutralino that, in many cases, prove to be more constraining than dark matter experiments themselves
Possible futures of electroweak precision: ILC, FCC-ee, and CEPC

The future of high-precision electroweak physics lies in e + e − collider measurements of properties of the Z boson, the W boson, the Higgs boson, and the top quark. We estimate the expected performance of three possible future colliders: the ILC, FCC-ee (formerly known as TLEP), and CEPC. In particular, we present the first estimates of the possible reach of CEPC, China’s proposed Circular Electron-Positron Collider, for the oblique parameters S and T and for seven-parameter fits of Higgs couplings. These results allow the physics potential for CEPC to be compared with that of the ILC and FCC-ee. We also show how the constraints on S and T would evolve as the uncertainties on each of the most important input measurements change separately. This clarifies the basic physics goals for future colliders. To improve on the current precision, the highest priorities are improving the uncertainties on m W and sin 2 θ eff . At the same time, improved measurements of the top mass, the Z mass, the running of α , and the Z width will offer further improvement which will determine the ultimate reach. Each of the possible future colliders we consider has strong prospects for probing TeV-scale electroweak physics
Boosted event topologies from TeV scale light quark composite partners

We propose a new search strategy for quark partners which decay into a boosted Higgs and a light quark. As an example, we consider phenomenologically viable right handed up-type quark partners of mass ∼ 1 TeV in composite pseudo-Nambu-Goldstone-boson Higgs models within the context of flavorful naturalness. Our results show that S/B > 1 and signal significance of ∼ 7σ is achievable at s = 14 $$ \sqrt{s}=14 $$ TeV LHC with 35 fb −1 of integrated luminosity, sufficient to claim discovery of a new particle. A combination of a multi-dimensional boosted Higgs tagging technique, kinematics of pair produced heavy objects and b -tagging serves to efficiently diminish the large QCD backgrounds while maintaining adequate levels of signal efficiency. We present the analysis in the context of effective field theory, such that our results can be applied to any future search for pair produced vector-like quarks with decay modes to Higgs and a light jet
Precision natural SUSY at CEPC, FCC-ee, and ILC

Testing the idea of naturalness is and will continue to be one of the most important goals of high energy physics experiments. It will play a central role in the physics program of future colliders. In this paper, we present projections of the reach of natural SUSY at future lepton colliders: CEPC, FCC-ee and ILC. We focus on the observables which give the strongest reach, the electroweak precision observables (for left-handed stops), and Higgs to gluon and photon decay rates (for both left- and right-handed stops). There is a “blind spot” when the stop mixing parameter X t is approximately equal to the average stop mass. We argue that in natural scenarios, bounds on the heavy Higgs bosons from tree-level mixing effects that modify the h b b ¯ $$ hb\overline{b} $$ coupling together with bounds from b → s γ play a complementary role in probing the blind spot region. For specific natural SUSY scenarios such as folded SUSY in which the top partners do not carry Standard Model color charges, electroweak precision observables could be the most sensitive probe. In all the scenarios discussed in this paper, the combined set of precision measurements will probe down to a few percent in fine-tuning
Teaching empirical finance courses: A project on portfolio management

The aim of this article is to assess the use of a group based project for an empirical finance type of course. It examines the outline of the project, the methodology the students are encouraged to follow and how the course is assessed. This approach enables the students to apply many of the techniques learnt on this course and other courses such as econometrics, to determine an optimal portfolio of assets given their view on the risks in the economy. The emphasis is on risk management through portfolio diversification and the use of a simple hedge strategy. The overall aim is to introduce the students to the basics of portfolio management, as many work in this industry for their industrial placements and when they graduate. The main contribution to the literature is through the analysis of an empirically based portfolio management project. The feedback from the students suggests they felt that they had learnt useful concepts and information, in an enjoyable exercise
Nanoelectrode ensembles as recognition platform for electrochemical immunosensors

In this study we demonstrate the possibility to prepare highly sensitive nanostructured electrochemical
immunosensors by immobilizing biorecognition elements on nanoelectrode ensembles (NEEs) prepared
in track-etch polycarbonate membranes. The gold nanodisk electrodes act as electrochemical transducers
while the surrounding polycarbonate binds the antibody-based biorecognition layer. The interaction
between target protein and antibody is detected by suitable secondary antibodies labelled with a redox
enzyme. A redox mediator, added to the sample solution, shuttles electrons from the nanoelectrodes to
the biorecognition layer, so generating an electrocatalytic signal. This allows one to fully exploit the highly
improved signal-to-background current ratio, typical of NEEs. In particular, the receptor protein HER2was
studied as the target analyte. HER2 detection allows the identification of breast cancer that can be treated
with the monoclonal antibody trastuzumab. NEEs were functionalized with trastuzumab which interacts
specifically with HER2. The biorecognition process was completed by adding a primary antibody and a
secondary antibody labelled with horseradish peroxidase. Hydrogen peroxide was added to modulate
the label electroactivity; methylene blue was the redox mediator generating voltammetric signals. NEEs
functionalized with trastuzumab were tested to detect small amounts of HER2 in diluted cell lysates and
tumour lysates
Timing of Mitigation and Technology Availability in Achieving a Low-Carbon World

This paper analyzes the economic and investment implications of a series of climate mitigation scenarios, characterized by different levels of ambition for long-term stabilization goals and transitional pathways. Results indicate that although milder climate objectives can be achieved at moderate costs, stringent stabilization paths, compatible with the 2°C target, might require significant economic resources. Innovation and technology are shown to be able to mitigate, but not structurally alter, this trade-off. Technologies that allow capturing CO2 from the atmosphere are shown to be important for expanding the feasibility space of stringent climate policies, though only if deployed at a scale which would represent a tremendous challenge. In general, the analysis indicates that the timing of mitigation is an important factor of cost containment, with early action being desirable. It also elaborates on the set of mitigation strategies and policies that would be required to achieve climate protection at maximum efficiency
Collective performance: modeling the interaction of habit-based actions

Recurring patterns of action are essential in our efforts to explain central properties of business firms and other organizations. However, the development of systematic theory has been hampered by the difficulty of adequately specifying foundational assumptions. We address this problem by defining a concept of collective performance, which brings together a range of recurring organizational action patterns that have been studied under labels such as “routine,” “practice,” standard operating procedure, or “genre of action.” All these forms of organizational action are based on human habit to a significant degree. We propose a conceptual framework for such habit-based organizational action patterns. The framework is a set of core principles and desirable model properties that can serve as a guide in the development of formal models of collective performance. It provides micro-foundations for the modeling of collective performance that are aligned with contemporary developments in psychology. Finally, we present a series of examples, developed in Supplementary Materials, that shows how our framework leads to new classes of formal models that can aid the analysis of collective performance
Modeling and numerical sensitivity study on the conjecture of a subglacial lake at Amundsenisen, Svalbard

We present a new numerical procedure to assess the plausibility of a subglacial lake in case of relative small/moderate extension and surging temperate icefield. In addition to the flat signal from Ground Penetrating Radar remote survey of the area, early indication of a likely subglacial lake, required icefield data are: top surface elevation and bathymetry, top surface velocity at some points, in-depth temperature and density profiles of upper layer. The procedure is based on a mathematical model of the evolution of dynamics and thermo-dynamics of the icefield and of a subglacial lake. The Glen’s law is adopted for ice rheology and Stokes reduction is applied; Large Eddy Simulation technique is used for the lake. Ice/water phase change is described. Finite volumes for model discretization and a front-tracking technique to follow the moving interface characterize the numerical method.\ud
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We have applied this procedure to the case of a subglacial lake conjectured in the area of Amundsenisen, Svalbard, and, here, the results of a sensitivity study are discussed. In particular we point out that the effect of firn and snow upper layers on the system, in terms of temperature field, density and water content, has to be included in the modeling, as it contributes to the overcoming of the ice metastable state and the release of subglacial water. Accordingly, ice water content changes have to be carefully described. The depth of the bed depression is confirmed to be critical for the formation of the lake
RD51, a world-wide collaboration for the development of Micro Pattern Gaseous Detectors

International audienceOriginally introduced to improve the rate capability of traditional wire chambers, Micro Pattern Gaseous Detectors (MPGD) actually demonstrate many more benefits. Be it for medical and industry imaging, collider experiments or more interestingly in the framework of this conference for the search of rare events, they are the subject of constant research and development in several laboratories over the world. The RD51 collaboration has been coordinating this work since April 2008 and is meant to advance the technological development and application of MPGD. The collaboration is presented and emphasis is put on its latest achievements which do make these devices an attractive option for the detection of low energy rare events: the possibility to instrument large area and to detect UV photons
EAS experiment on board of the Airbus A380

We consider taking the opportunity of about 10.000 hours of test of the Airbus A380, and to install at passenger space detectors for high energy cosmic ray events. The altitude of 10 km (250 g/cm 2 ) would give opportunity to measure EAS originating from heavy primaries to energies exceeding 10 7 GeV, and also coming without interaction proton component beyond the energy of the knee. At the altitude the iron originated EAS are well developed and registering their lateral distribution in 70 meters long cabin it is possible to distinguish them from proton originated EAS. Hadron component of EAS (registered as number of secondary hadrons produced in the detector) would help in discrimination and energy estimation. On another hand, registrations of high energy protons (without EAS) would enable to measure high energy proton spectrum. The energy of the proton would be estimated via hadron multiplicity in single interaction inside the detector. We propose to use about 60 modules of 0.5 m 2 of active detectors with scintillators to detect E-M component and carbon target with lead layer to detect the hadronic component via neutron registrations