pinecone/core-2020-05-10-deduplication huggingface dataset:
The impact of supportive nursing care on the needs of men with prostate cancer: a study across seven European countries.

Background:Prostate cancer is for many men a chronic disease with a long life expectancy after treatment. The impact of prostate cancer therapy on men has been well defined, however, explanation of the consequences of cancer treatment has not been modelled against the wider variables of long-term health-care provision. The aim of this study was to explore the parameters of unmet supportive care needs in men with prostate cancer in relation to the experience of nursing care.Methods:A survey was conducted among a volunteer sample of 1001 men with prostate cancer living in seven European countries.Results:At the time of the survey, 81% of the men had some unmet supportive care needs including psychological, sexual and health system and information needs. Logistic regression indicated that lack of post-treatment nursing care significantly predicted unmet need. Critically, men's contact with nurses and/or receipt of advice and support from nurses, for several different aspects of nursing care significantly had an impact on men's outcomes.Conclusion:Unmet need is related not only to disease and treatment factors but is also associated with the supportive care men received. Imperative to improving men's treatment outcomes is to also consider the access to nursing and the components of supportive care provided, especially after therapy
WASI-2D - A software tool for regionally optimized analysis of imaging spectrometer data from deep and shallow waters

An image processing software has been developed which allows quantitative analysis of multi- and hyperspectral data from oceanic, coastal and inland waters. It has been implemented into the Water Colour Simulator WASI, which is a tool for the simulation and analysis of optical properties and light field parameters of deep and shallow waters. The new module WASI-2D can import atmospherically corrected images from airborne sensors and satellite instruments in various data formats and units like remote sensing reflectance or radiance. It can be easily adapted by the user to different sensors and to optical properties of the studied area. Data analysis is done by inverse modelling using established analytical models. The bio-optical model of the water column accounts for gelbstoff (coloured dissolved organic matter, CDOM), detritus, and mixtures of up to 6 phytoplankton classes and 2 spectrally different types of suspended matter. The reflectance of the sea floor is treated as sum of up to 6 substrate types. An analytic model of downwelling irradiance allows wavelength dependent modelling of sun glint and sky glint at the water surface. The provided database covers the spectral range from 350 to 1000 nm in 1 nm intervals. It can be exchanged easily to represent the optical properties of water constituents, bottom types and the atmosphere of the studied area
Responsible management : engaging moral reflexive practice through threshold concepts

In this conceptual paper we argue that, to date, principles of responsible management have not impacted practice as anticipated because of a disconnect between knowledge and practice. This disconnect means that an awareness of ethical concerns, by itself, does not help students take personal responsibility for their actions. We suggest that an abstract knowledge of principles has to be supplemented by an engaged understanding of the responsibility of managers and leaders to actively challenge irresponsible practices. We argue that a form of moral reflexive practice drawing on an understanding of threshold concepts is central to responsible management, and provides a gateway to transformative learning. Our conceptual argument leads to implications for management and professional education.PostprintPeer reviewe
A globin domain in a neuronal transmembrane receptor of caenorhabditis elegans and ascaris suum : molecular modeling and functional properties

We report the structural and biochemical characterization of GLB-33, a putative neuropeptide receptor that is exclusively expressed in the nervous system of the nematode Caenorhabditis elegans. This unique chimeric protein is composed of a 7-transmembrane domain (7TM), GLB-33 7TM, typical of a G-protein-coupled receptor, and of a globin domain (GD), GLB-33 GD. Comprehensive sequence similarity searches in the genome of the parasitic nematode, Ascaris suum, revealed a chimeric protein that is similar to a Phe-Met-Arg-Phe-amide neuropeptide receptor. The three-dimensional structures of the separate domains of both species and of the full-length proteins were modeled. The 7TM domains of both proteins appeared very similar, but the globin domain of the A. suum receptor surprisingly seemed to lack several helices, suggesting a novel truncated globin fold. The globin domain of C. elegans GLB-33, however, was very similar to a genuine “myoglobin”-type molecule. Spectroscopic analysis of the recombinant GLB-33 GD showed that the heme is pentacoordinate when ferrous and in the hydroxide-ligated formwhenferric, even at neutral pH. Flash-photolysis experiments showed overall fast biphasic CO rebinding kinetics. In its ferrous deoxy form, GLB-33GDis capable of reversibly binding O2 with a very high affinity and of reducing nitrite to nitric oxide faster than other globins. Collectively, these properties suggest that the globin domain of GLB-33 may serve as a highly sensitive oxygen sensor and/or as a nitrite reductase. Both properties are potentially able to modulate the neuropeptide sensitivity of the neuronal transmembrane receptor
Design concepts for the Cherenkov Telescope Array CTA: an advanced facility for ground-based high-energy gamma-ray astronomy

Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5–10 improvement in sensitivity in the 100 GeV–10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA
Experimental investigation of the 0+2 band in Sm154 as a β -vibrational band

A study of Sm154 through γ -ray and internal conversion electron coincidence measurements was performed using the Silicon And GErmanium spectrometer (SAGE). An upper limit for the ρ2(E0;2+2→2+1) and measurement of the ρ2(E0;4+2→4+1) monopole transitions strengths were determined. The extracted transition strength for each is significantly lower than that predicted by either the Bohr and Mottelson β -vibration description or the interacting boson model. Hence, the long standing interpretation of these states as a collective band built on the 0+2 state, which is conventionally assigned as a Bohr and Mottelson β vibration is questionable
First determination of the one-proton induced Non-Mesonic Weak Decay width of p -shell Λ -Hypernuclei

Previous studies of proton and neutron spectra from Non-Mesonic Weak Decay of eight Λ -Hypernuclei ( A=5–16 ) have been revisited. New values of the ratio of the two-nucleon and the one-proton induced decay widths, Γ2N/Γp , are obtained from single proton spectra, Γ2N/Γp=0.50±0.24 , and from neutron and proton coincidence spectra, Γ2N/Γp=0.36±0.14stat−0.04sys+0.05sys , in full agreement with previously published ones. With these values, a method is developed to extract the one-proton induced decay width in units of the free Λ decay width, Γp/ΓΛ , without resorting to Intra Nuclear Cascade models but by exploiting only experimental data, under the assumption of a linear dependence on A of the Final State Interaction contribution. This is the first systematic determination ever done and it agrees within the errors with recent theoretical calculations
Charged Rényi entropies and holographic superconductors

Charged Rényi entropies were recently introduced as a measure of entanglement between different charge sectors of a theory. We investigate the phase structure of charged Rényi entropies for CFTs with a light, charged scalar operator. The charged Rényi entropies are calculated holographically via areas of charged hyperbolic black holes. These black holes can become unstable to the formation of scalar hair at sufficiently low temperature; this is the holographic superconducting instability in hyperbolic space. This implies that the Rényi entropies can be non-analytic in the Rényi parameter n . We find the onset of this instability as a function of the charge and dimension of the scalar operator. We also comment on the relation between the phase structure of these entropies and the phase structure of a holographic superconductor in flat space
Oscillations above the barrier in the fusion of 28 Si + 28 Si

Fusion cross sections of 28 Si + 28 Si have been measured in a range above the barrier with a very small energy step ( ΔElab=0.5 MeV ). Regular oscillations have been observed, best evidenced in the first derivative of the energy-weighted excitation function. For the first time, quite different behaviors (the appearance of oscillations and the trend of sub-barrier cross sections) have been reproduced within the same theoretical frame, i.e., the coupled-channel model using the shallow M3Y + repulsion potential. The calculations suggest that channel couplings play an important role in the appearance of the oscillations, and that the simple relation between a peak in the derivative of the energy-weighted cross section and the height of a centrifugal barrier is lost, and so is the interpretation of the second derivative of the excitation function as a barrier distribution for this system, at energies above the Coulomb barrier
Towards a first estimate of the gluon Sivers function from A N data in pp collisions at RHIC

Within a generalized parton model approach, with inclusion of spin and intrinsic transverse momentum effects, we show how the latest, highly precise, midrapidity data on the transverse single spin asymmetry measured in pp → π 0 X by the PHENIX Collaboration at RHIC [1], can be used to get a first estimate on the still poorly known gluon Sivers distribution. To this end we also adopt the present information on the quark Sivers functions, as extracted from semi-inclusive deeply inelastic scattering data. This analysis updates a previous study by some of us where a first bound on this distribution was obtained [2]
Influence of normal and radial contributions of local current density on local electrochemical impedance spectroscopy

A new tri-electrode probe is presented and applied to local electrochemical impedance spectroscopy (LEIS) measurements. As opposed to two-probe systems, the three-probe one allows measurement not only of normal, but also of radial contributions of local current densities to the local impedance values. The results concerning the cases of the blocking electrode and the electrode with faradaic reaction are discussed from the theoretical point of view for a disk electrode. Numerical simulations and experimental results are compared for the case of the ferri/ferrocyanide electrode reaction at the Pt working electrode disk. At the centre of the disk, the impedance taking into account both normal and radial contributions was in good agreement with the local impedance measured in terms of only the normal contribution. At the periphery of the electrode, the impedance taking into account both normal and radial contributions differed significantly from the local impedance measured in terms of only the normal contribution. The radial impedance results at the periphery of the electrode are in good agreement with the usual explanation that the associated larger current density is attributed to the geometry of the electrode, which exhibits a greater accessibility at the electrode edge. (C) 2011 Elsevier Ltd. All rights reserved.CAPESCharles A. Stokes professorshi
Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5'-GCGC-3'.

N-Methylpyrrole (Py)-N-methylimidazole (Im) polyamides are small organic molecules that can recognize predetermined DNA sequences with high sequence specificity. As many eukaryotic promoter regions contain highly GC-rich sequences, it is valuable to synthesize and characterize Py-Im polyamides that recognize GC-rich motifs. In this study, we synthesized four hairpin Py-Im polyamides 1-4, which recognize 5'-GCGC-3' and investigated their binding behavior with surface plasmon resonance assay. Py-Im polyamides 2-4 contain two, one, and one β-alanine units, replacing the Py units of 1, respectively. The binding affinities of 2-4 to the target DNA increased 430, 390, and 610-fold, respectively, over that of 1. The association and dissociation rates of 2 to the target DNA were improved by 11 and 37-fold, respectively, compared with those of 1. Interestingly, the association and dissociation rates of 3 and 4 were higher than those of 2, even though the binding affinities of 2, 3, and 4 to the target DNA were comparable to each other. The binding affinity of 2 to DNA with a 2bp mismatch was reduced by 29-fold, compared with that to the matched DNA. Moreover, the binding affinities of 3 and 4 to the same mismatched DNA were reduced by 270 and 110-fold, respectively, indicating that 3 and 4 have greater specificities than 2 and are suitable as DNA-binding modules for engineered epigenetic regulation
Complex wave propagation in the Campi Flegrei Caldera, Italy,from Source and receiver-array analysis of sea-shot recordings

We investigate wave propagation in the complex shallow crust of Campi Flegrei
Volcanic Complex, Italy, using array recordings of air-guns. We apply source- and
receiver-array analysis to define the independent variation of horizontal slowness at
both the source and receiver regions. This method allows the identification of
asymmetric ray-paths associated with near-source and near-observer velocity
heterogeneities. P-wave wave-vectors at both the source and receiver arrays depict
discrepancies as large as 50° with respect to the values expected for the 3D velocity
structure of the Gulf. At the source region, these discrepancies may be associated with
either un-modelled complexities in the geometry of the buried caldera rim, or with
velocity variations beneath the source-array. At the receiver array, the inferred
anomalies may be attributed to velocity variations marking the Solfatara crater rim, or
to a near-receiver, low-velocity body whose position would coincide with negative
gravimetric anomalies and a low Vp/Vs ratio region inferred by independent
geophysical and seismological studies
Discrimination of tsunami sources (Earthquake vs. Landslide) on the basis of historical data in Eastern Sicily and southern Calabria

The source mechanisms responsible for large historical tsunamis that
have struck eastern Sicily and southern Calabria are a topic of robust debate. We have
compiled a database of historical coeval descriptions of three large tsunamis: 11 January
1693, 6 February 1783, and 28 December 1908. By using accounts of run-up and
inundation and employing an approach proposed by Okal and Synolakis in 2004, we
can provide discriminants to define the nature of the near-field tsunami sources (fault
dislocation or landslide).
Historical reports for the 1908 event describe affected localities, maximum runups,
and inundation areas. However, for the 1693 and 1783 tsunamis, reports are
limited to inundation and occasional run-up estimates. We calculate run-up values
for these events using available relations between inundation and run-up. We
employed the model of Okal and Synolakis to the obtained profiles of tsunami
run-up along the inundated shorelines. The 1908 run-up data distribution confirms
that the tsunami is compatible with a seismic dislocation source, whereas the
1783 data supports contemporary observations and recent offshore investigations suggesting
that the tsunami was produced by an earthquake-triggered submarine landslide.
Analysis of the 1693 event data suggests that the tsunami was generated
during a tectonic event and thus a seismogenic source should be found offshore
Seismological investigations in the Gioia Tauro Basin (southern Calabria, Italy)

This study provides new seismological information to characterize the seismically active area of the Gioia
Tauro basin (southern Calabria, Italy). Seismic activity recorded by a temporary network from 1985 to 1994 was
analyzed for focal mechanisms, stress tensor inversion, P-wave seismic attenuation and earthquake source parameters
estimation. Fault plane solutions of selected events showed a variety of different mechanisms, even if
a prevalence of normal dip-slip solutions with prevalent rupture orientations occurring along ca. NE-SW directions
was observed. Stress tensor inversion analysis disclosed a region governed mainly by a NW-SE extensional
stress regime with a nearly vertical σ1. These results are consistent with the structure movements affecting
the studied area and with geodetic data.
Furthermore, evaluation of P-waves seismic attenuation and earthquake source parameters of a subset of events
highlighted a strong heterogeneity of the crust and the presence of fault segments and/or weakened zones where
great stress accumulation or long-rupture propagation are hindered
Wireless ad hoc networks: an overview

This tutorial provides a general view on the research field of\ud
ad hoc networks. After a definition of the concept, the discussion concentrates\ud
on enabling technologies, including physical and medium access\ud
control layers, networking and transport issues. We find discussions on\ud
the adequacy of enabling technologies for wireless multihop communication,\ud
specifically in the case of the pervasive Bluetooth and IEEE 802.11.\ud
Then, a variety of dynamic routing protocols are presented and specific\ud
issues that are relevant in this context are highlighted. After a short\ud
discussion on TCP issues in this context, we look at power awareness,\ud
which is a very important issue in this scenario. Finally, we discuss proposals\ud
that aim at maintaining Service Level Agreements in isolated ad\ud
hoc networks and ad hoc networks connected to fixed networks.Postprint (published version
Crustal growth during island arc accretion and transcurrent deformation, Natal Metamorphic Province, South Africa : new isotopic constraints

Natural Environment Research Council (NERC grant NE/J021822/1) provided financial support for this study.The Natal Metamorphic Province consists of, from north to south, the Tugela, Mzumbe, and Margate terranes. These were accreted to the southeastern margin of the Kaapvaal Craton in the late Mesoproterozoic, and followed by intrusion of a large suite of A-type granitoid bodies. New U-Pb data from zircon, titanite, and monazite further constrains the temporal framework of these geological events. The Tugela and Mzumbe terranes record protracted magmatism in an island arc complex from ∼1200 Ma to 1160 Ma, followed by the accretion of these terranes onto the southern margin of the Kaapvaal Craton at ∼1150 Ma. Arc magmatism in the Margate Terrane continued until ∼1120 Ma and was followed by extension and bimodal volcanism immediately prior to accretion to the Kaapvaal/Mzumbe continental margin at ∼1090 Ma. This accretion was accompanied by high-pressure and high-temperature metamorphism, juxtaposition of the Mzumbe and Margate terranes along the Melville Thrust, and the formation of a number of syntectonic intrusive units derived from melting of the pre-existing arc crust. After accretion, extensional collapse is evidenced by the intrusion of mafic/ultramafic and alkaline intermediate magmatic suites at ∼1085 Ma, resulting from mafic underplating and/or lower crustal delamination. Nd and Hf isotopic data imply the magmatic rocks of the Natal Metamorphic Province were derived from relatively juvenile continental crust, initially generated by island arc magmatism and subsequently reworked during the accretion event(s). The combined Kaapvaal-NMP region (the southern margin of the enlarged Kalahari Craton) then experienced extensive sinistral transcurrent deformation centered along a series of discrete steep shear zones that are found from the Kaapvaal cratonic margin to the southernmost portion of the Natal Metamorphic Province. This deformation is accompanied by low-pressure, (ultra)high-temperature metamorphism, isobaric cooling, and intrusion of the voluminous A-type Oribi Gorge Suite porphyritic granites and charnockites throughout the Mzumbe and Margate Terranes.PostprintPeer reviewe
Pointed Hopf algebras with triangular decomposition:A characterization of multiparameter quantum groups

In this paper, we present an approach to the definition of multiparameter quantum groups by studying Hopf algebras with triangular decomposition. Classifying all of these Hopf algebras which are of what we call weakly separable type over a group, we obtain a class of pointed Hopf algebras which can be viewed as natural generalizations of multiparameter deformations of universal enveloping algebras of Lie algebras. These Hopf algebras are instances of a new version of braided Drinfeld doubles, which we call asymmetric braided Drinfeld doubles. This is a generalization of an earlier result by Benkart and Witherspoon (Algebr. Represent. Theory 7(3) ? BC) who showed that two-parameter quantum groups are Drinfeld doubles. It is possible to recover a Lie algebra from these doubles in the case where the group is free abelian and the parameters are generic. The Lie algebras arising are generated by Lie subalgebras isomorphic to (Formula presented.)
Optimal inference with suboptimal models:Addiction and active Bayesian inference

When casting behaviour as active (Bayesian) inference, optimal inference is defined with respect to an agent's beliefs - based on its generative model of the world. This contrasts with normative accounts of choice behaviour, in which optimal actions are considered in relation to the true structure of the environment - as opposed to the agent's beliefs about worldly states (or the task). This distinction shifts an understanding of suboptimal or pathological behaviour away from aberrant inference as such, to understanding the prior beliefs of a subject that cause them to behave less 'optimally' than our prior beliefs suggest they should behave. Put simply, suboptimal or pathological behaviour does not speak against understanding behaviour in terms of (Bayes optimal) inference, but rather calls for a more refined understanding of the subject's generative model upon which their (optimal) Bayesian inference is based. Here, we discuss this fundamental distinction and its implications for understanding optimality, bounded rationality and pathological (choice) behaviour. We illustrate our argument using addictive choice behaviour in a recently described 'limited offer' task. Our simulations of pathological choices and addictive behaviour also generate some clear hypotheses, which we hope to pursue in ongoing empirical work