pinecone/core-2020-05-10-deduplication huggingface dataset:
Unifying the PST and the auxiliary tensor field formulations of 4D self-duality

AbstractWe unify the Lorentz- and O(2) duality-covariant approach to 4D self-dual theories by Pasti, Sorokin and Tonin (PST) with the formulation involving an auxiliary tensor field. We present the basic features of the new hybrid approach, including symmetries of the relevant generalized PST action. Its salient peculiarity is the unique form of the realization of the PST gauge symmetries. The corresponding transformations do not affect the auxiliary tensor field, which guarantees the self-duality of the nonlinear actions in which the O(2) invariant interactions are constructed out of the tensor field
On the relation between the full Kostant–Toda lattice and multiple orthogonal polynomials

AbstractThe correspondence between a high-order non-symmetric difference operator with complex coefficients and the evolution of an operator defined by a Lax pair is established. The solution of the discrete dynamical system is studied, giving explicit expressions for the resolvent function and, under some conditions, the representation of the vector of functionals, associated with the solution for our integrable systems. The method of investigation is based on the evolutions of the matrical moments
Analysing powers and spin correlations in deuteron–proton charge exchange at 726 MeV

AbstractThe charge exchange of vector polarised deuterons on a polarised hydrogen target has been studied in a high statistics experiment at the COSY-ANKE facility at a deuteron beam energy of Td=726 MeV. By selecting two fast protons at low relative energy Epp, the measured analysing powers and spin correlations are sensitive to interference terms between specific neutron–proton charge-exchange amplitudes at a neutron kinetic energy of Tn≈12Td=363 MeV. An impulse approximation calculation, which takes into account corrections due to the angular distribution in the diproton, describes reasonably the dependence of the data on both Epp and the momentum transfer. This lends broad support to the current neutron–proton partial wave solution that was used in the estimation
Excitation of giant monopole resonance in 208Pb and 116Sn using inelastic deuteron scattering

AbstractThe excitation of the isoscalar giant monopole resonance (ISGMR) in 208Pb and 116Sn has been investigated using small-angle (including 0°) inelastic scattering of 100 MeV/u deuteron and multipole-decomposition analysis (MDA). The extracted strength distributions agree well with those from inelastic scattering of 100 MeV/u α particles. These measurements establish deuteron inelastic scattering at Ed∼100 MeV/u as a suitable probe for extraction of the ISGMR strength with MDA, making feasible the investigation of this resonance in radioactive isotopes in inverse kinematics
A Weil–Barsotti formula for Drinfeld modules

AbstractWe study the group of extensions in the category of Drinfeld modules and Anderson's t-modules, and we show in certain cases that this group can itself be given the structure of a t-module. Our main result is a Drinfeld module analogue of the Weil–Barsotti formula for abelian varieties. Extensions of general t-modules are also considered, in particular extensions of tensor powers of the Carlitz module. We motivate these results from various directions and compare to the situation of elliptic curves
Adverse drug reactions in some African herbal medicine: literature review and stakeholders’ interview

AbstractBackgroundIn view of the large consumption of herbal medicine in Africa countries, it is likely that many adverse drugs reactions go unrecorded with either patients failing to present to health services, or no pharmacovigilance analysis being made, or the analysis not being reported centrally. This problem is of interest especially for those who are working in the general area of adverse drug reactions or stakeholders in the domain of herbal medicine for considering safety issues.MethodsWe are particularly interested in the way that the use of very well-known and highly valued plants is linked to the observation of adverse drug reactions in African countries. We investigated, through a literature review and using the Internet (with a semantic search strategy), some well-known or popular medicinal plants used in African herbal medicine (AHM). Other information on the properties related to use, and characteristics of medicinal plants was complemented by some interviews with stakeholders.ResultsAlthough substantial progress has been made in elucidating the mechanisms of action of many drugs, the pharmacological actions of many medicinal plants are generally not well understood. The results of a literature review suggest that the reported adverse drug reactions of herbal remedies are often due to a lack of understanding of their preparation and appropriate use. The results of stakeholders’ interviews suggest that there is a growing need to provide patients with correct information about the herbal medicines they consume.ConclusionAn important aspect of herbal medicine is the correct, timely, and integrated communication of emerging data on risk as an essential part of pharmacovigilance, which could actually improve the health and safety of patients. This calls for improved collaboration between traditional practitioners and modern healthcare professionals, researchers, and drug regulatory authorities. In addition, there is a need for an adverse drug reaction reporting system to facilitate the collection, monitoring, and evaluation of adverse drug events
Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain.

PublishedJournal ArticleThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.Although mutations within the TREM2 gene have been robustly associated with Alzheimer's disease, it is not known whether alterations in the regulation of this gene are also involved in pathogenesis. Here, we present data demonstrating increased DNA methylation in the superior temporal gyrus in Alzheimer's disease brain at a CpG site located 289 bp upstream of the transcription start site of the TREM2 gene in 3 independent study cohorts using 2 different technologies (Illumina Infinium 450K methylation beadchip and pyrosequencing). A meta-analysis across all 3 cohorts reveals consistent AD-associated hypermethylation (p = 3.47E-08). This study highlights that extending genetic studies of TREM2 in AD to investigate epigenetic changes may nominate additional mechanisms by which disruption to this gene increases risk.This work was funded by a grant from BRACE (Bristol Research into Alzheimer's and Care of the Elderly) and the Alzheimer's Society (grant number AS-PG-14-038) to Katie Lunnon and NIH grant R01 AG036039 and an Equipment Grant from Alzheimer's Research UK to Jonathan Mill. The authors thank Carolyn Sloan for technical support and Istvan Bodi and Andrew King for neuropathological diagnosis of cases. The authors also thank the Oxford Project to Investigate Memory and Ageing (OPTIMA), the National Institute for Health (NIHR), Biomedical Research Unit in Dementia in the South London and Maudsley NHS Foundation Trust (SLaM), Brains for Dementia Research (Alzheimer Brain Bank UK) and the donors and families who made this research possible. The Oxford Brain Bank is supported in part by the National Institute for Health Research (NIHR), Oxford Biomedical Research Centre based at Oxford University Hospitals NHS Trust and University Of Oxford. Brain banking and neuropathology assessments for the Mount Sinai cohort was supported by NIH grants AG02219, AG05138, and MH064673 and the Department of Veterans AffairsVISN3 MIRECC
Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.

On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

Background: Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods: We analysed, with use of a consistent protocol, population-based studies that had measured height and weight in adults aged 18 years and older. We applied a Bayesian hierarchical model to these data to estimate trends from 1975 to 2014 in mean BMI and in the prevalences of BMI categories (<18·5 kg/m2 [underweight], 18·5 kg/m2 to <20 kg/m2, 20 kg/m2 to <25 kg/m2, 25 kg/m2 to <30 kg/m2, 30 kg/m2 to <35 kg/m2, 35 kg/m2 to <40 kg/m2, ≥40 kg/m2 [morbid obesity]), by sex in 200 countries and territories, organised in 21 regions. We calculated the posterior probability of meeting the target of halting by 2025 the rise in obesity at its 2010 levels, if post-2000 trends continue. Findings: We used 1698 population-based data sources, with more than 19·2 million adult participants (9·9 million men and 9·3 million women) in 186 of 200 countries for which estimates were made. Global age-standardised mean BMI increased from 21·7 kg/m2 (95% credible interval 21·3–22·1) in 1975 to 24·2 kg/m2 (24·0–24·4) in 2014 in men, and from 22·1 kg/m2 (21·7–22·5) in 1975 to 24·4 kg/m2 (24·2–24·6) in 2014 in women. Regional mean BMIs in 2014 for men ranged from 21·4 kg/m2 in central Africa and south Asia to 29·2 kg/m2 (28·6–29·8) in Polynesia and Micronesia; for women the range was from 21·8 kg/m2 (21·4–22·3) in south Asia to 32·2 kg/m2 (31·5–32·8) in Polynesia and Micronesia. Over these four decades, age-standardised global prevalence of underweight decreased from 13·8% (10·5–17·4) to 8·8% (7·4–10·3) in men and from 14·6% (11·6–17·9) to 9·7% (8·3–11·1) in women. South Asia had the highest prevalence of underweight in 2014, 23·4% (17·8–29·2) in men and 24·0% (18·9–29·3) in women. Age-standardised prevalence of obesity increased from 3·2% (2·4–4·1) in 1975 to 10·8% (9·7–12·0) in 2014 in men, and from 6·4% (5·1–7·8) to 14·9% (13·6–16·1) in women. 2·3% (2·0–2·7) of the world's men and 5·0% (4·4–5·6) of women were severely obese (ie, have BMI ≥35 kg/m2). Globally, prevalence of morbid obesity was 0·64% (0·46–0·86) in men and 1·6% (1·3–1·9) in women. Interpretation: If post-2000 trends continue, the probability of meeting the global obesity target is virtually zero. Rather, if these trends continue, by 2025, global obesity prevalence will reach 18% in men and surpass 21% in women; severe obesity will surpass 6% in men and 9% in women. Nonetheless, underweight remains prevalent in the world's poorest regions, especially in south Asia
Associations between Age, Years in Post, Years in the Profession and Personal Experience of Mental Health Problems in UK Mental Health Nurses

Nurses' mental health is of paramount importance, both in terms of patient safety and the sustainability of the workforce. Age, years in the profession, in post and personal experience or exposure to mental health problems are relevant to the mental health nursing workforce crisis in the United Kingdom. This study aimed to determine the relationship between age, years in the profession and post and self-reported experience of mental health problems using an online cross-sectional survey of 225 UK mental health nurses. Number of years in post was inversely correlated with overall experience of mental health problems, particularly living with someone else with mental health problems. Those with experience of living with someone with mental health problems had significantly fewer years of professional experience than those without. This article discusses possible explanations for this phenomenon and makes the case for future research on the topic
Housework over the course of relationships: Gender ideology, resources, and the division of housework from a growth curve perspective

In the 21st century, the division of housework remains gendered, with women on average still spending\ud
more time doing chores than their male partners. While research has studied why this phenomenon is so\ud
persistent, few studies have yet been able to assess the effect of gender ideology and socio-economic\ud
resources at the same time, usually due to data restrictions. We use data from the pairfam, a new and\ud
innovative German panel study, in order to test the effect of absolute and relative resources as well as his\ud
and her gender ideology on the division of housework. We employ a life course perspective and analyze\ud
trajectories of couples' housework division over time, using multi-level random effects growth curve\ud
models. We find that an egalitarian gender ideology of both him and her significantly predicts more egalitarian division-trajectories, while neither absolute nor relative resources appear to have an effect on the division of housework over time. Furthermore, our results expand the literature by investigating how these processes differ among childless couples and couples who experience the\ud
first birth
The Gaia-ESO Survey: double, triple and quadruple-line spectroscopic
  binary candidates

The Gaia-ESO Survey (GES) is a large spectroscopic survey that provides a
unique opportunity to study the distribution of spectroscopic multiple systems
among different populations of the Galaxy. We aim at detecting
binarity/multiplicity for stars targeted by the GES from the analysis of the
cross-correlation functions (CCFs) of the GES spectra with spectral templates.
We develop a method based on the computation of the CCF successive derivatives
to detect multiple peaks and determine their radial velocities, even when the
peaks are strongly blended. The parameters of the detection of extrema (DOE)
code have been optimized for each GES GIRAFFE and UVES setup to maximize
detection. This code therefore allows to automatically detect multiple line
spectroscopic binaries (SBn, n>1). We apply this method on the fourth GES
internal data release and detect 354 SBn candidates (342 SB2, 11 SB3 and even
one SB4), including only 9 SB2 known in the literature. This implies that about
98% of these SBn candidates are new (because of their faint visual magnitude
that can reach V=19). Visual inspection of the SBn candidate spectra reveals
that the most probable candidates have indeed a composite spectrum. Among SB2
candidates, an orbital solution could be computed for two previously unknown
binaries: 06404608+0949173 (known as V642 Mon) in NGC 2264 and 19013257-0027338
in Berkeley 81. A detailed analysis of the unique SB4 (four peaks in the CCF)
reveals that HD 74438 in the open cluster IC 2391 is a physically bound stellar
quadruple system. The SB candidates belonging to stellar clusters are reviewed
in detail to discard false detections. We warn against the use of atmospheric
parameters for these system components rather than by SB-specific pipelines.
Our implementation of an automatic detection of spectroscopic binaries within
the GES has allowed an efficient discovery of many new multiple systems.Comment: 36 pages, 30 figures, 12 tables. Accepted for publication by A&A on
  2017-07-0
Impact of adjuvants on CD4+ T cell and B cell responses to a protein antigen vaccine : results from a phase II, randomized, multicenter trial

Immunogenicity and safety of different adjuvants combined with a model antigen (HBsAg) were compared. Healthy HBV-naive adults were randomized to receive HBs adjuvanted with alum or Adjuvant Systems AS01B, AS01E, AS03A or AS04 at Days 0 and 30. Different frequencies of HBs-specific CD4+ T cells 14 days post dose 2 but similar polyfunctionality profiles were induced by the different adjuvants with frequencies significantly higher in the AS01B and AS01E groups than in the other groups. Antibody concentrations 30 days post-dose 2 were significantly higher in AS01B, AS01E and AS03A than in other groups. Limited correlations were observed between HBs-specific CD4+ T cell and antibody responses. Injection site pain was the most common solicited local symptom and was more frequent in AS groups than in alum group. Different adjuvants formulated with the same antigen induced different adaptive immune responses and reactogenicity patterns in healthy naive adults
It's not just the therapist: Therapist and country-wide experience predict therapist adherence and adolescent outcome

Contains fulltext :
                  173905.pdf (publisher's version ) (Open Access)Objective: Therapist adherence is a quality indicator in routine clinical care when evaluating the success of the implementation of an intervention. The current study investigated whether therapist adherence mediates the association between therapist, team, and country-wide experience (i.e. number of years since implementation in the country) on the one hand, and treatment outcome on the other hand. We replicated and extended a study by Löfholm et al. (2014). Method: Data over a 10-year period were obtained from 4290 adolescents (12-17 years) with antisocial or delinquent problem behavior, who were treated with Multisystemic Therapy (MST) by 222 therapists, working in 27 different teams in the Netherlands. Multilevel structural equation modeling was used to assess the associations between experience, therapist adherence, and post-treatment outcomes. Results: Treatment outcomes were directly predicted by therapist experience, countrywide experience, and therapist adherence, but not by team experience. Moreover, therapist adherence mediated the association between therapist and country-wide experience, and treatment outcomes. The association between therapist experience and therapist adherence was not affected by the number of years of team experience or country-wide experience. Conclusion: The effect of country-wide experience on outcome may reflect increasing experience of training and supporting the therapists. It suggests that nation-wide quality control may relate to better therapist adherence and treatment outcome for adolescents treated with systemic therapy.17 p
Search for heavy lepton resonances decaying to a Z boson and a lepton in pp collisions at √s = 8 TeV with the ATLAS detector

Journal of High Energy Physics 2015.9 (2015): 108 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)Artículo escrito por muchos autores, sólo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración y los autores que firman como pertenecientes a la UAMA search for heavy leptons decaying to a Z boson and an electron or a muon
is presented. The search is based on pp collision data taken at √
s = 8 TeV by the ATLAS
experiment at the CERN Large Hadron Collider, corresponding to an integrated luminosity
of 20.3 fb−1
. Three high-transverse-momentum electrons or muons are selected, with two
of them required to be consistent with originating from a Z boson decay. No significant
excess above Standard Model background predictions is observed, and 95% confidence level
limits on the production cross section of high-mass trilepton resonances are derived. The
results are interpreted in the context of vector-like lepton and type-III seesaw models. For
the vector-like lepton model, most heavy lepton mass values in the range 114–176 GeV
are excluded. For the type-III seesaw model, most mass values in the range 100–468 GeV
are excludedWe acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia;
BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT and NSRF, Greece; RGC, Hong Kong SAR, China; ISF, MINERVA, GIF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW and NCN, Poland; GRICES and FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of Americ
Estimate of social and environmental costs for the urban distribution of goods: practical case for the city of Barcelona

The objective of the formulation is to allow to evaluate easily the costs of the urban distribution of goods by means of wheeled vehicles, and to formalize a methodological outline for the mentioned evaluation, which allows its updating and amplification when it was necessary. The sensitivity of the model illustrates the behaviour of the social costs in front of variations of the parameters which intervene in the model. The social costs which are analyzed in this article are the costs of the polluting emissions of the commercial vehicles, the costs of the noise emitted by the same ones, the costs which generate these vehicles in congestion and the costs of the accidents associated to their circulation. The costs of polluting emissions are considered with a matrix model based on an updating of the deliverable 22 of the project MEET. The costs of the noise are associated to the cost of using asphalt noise reducer in the streets with a high daily average intensity. The congestion costs are evaluated starting from the losses of time of the drivers of the commercial vehicles in Barcelona. The costs of accidents are quantified starting from the accident rate studies and mobility in the city of Barcelona.Peer ReviewedPostprint (author's final draft
Uncertainty in competitive bidding:A framework for product-service systems

Owing to servitisation, manufacturing companies are increasingly required to compete through the provision of services around their products. The contracts for these services are often allocated through competitive bidding where the potential suppliers submit a price bid to the customer. The pricing decision is influenced by various uncertainties. This article proposes a conceptual framework depicting these influencing uncertainties on the bidding strategy. This framework is based on three empirical studies with industry investigating different viewpoints on the decision-making process. The intention is to support the pricing decision when competitively bidding for a service contract. The framework can be applied to specific competitive bidding situations to identify the influencing uncertainties, model them and depict their influences on the pricing decision