pinecone/core-2020-05-10-deduplication huggingface dataset:
Vehicle routing problems with alternative paths: an application to on-demand transportation

20 pagesInternational audienceThe class of vehicle routing problems involves the optimization of freight or passenger transportation activities. These problems are generally treated via the representation of the road network as a weighted complete graph. Each arc of the graph represents the shortest route for a possible origin-destination connection. Several attributes can be deﬁned for one arc (travel time, travel cost . . . ), but the shortest route modelled by this arc is computed according to one single criterion, generally travel time. Consequently, some alternative routes proposing a diﬀerent compromise between the attributes of the arcs are discarded from the solution space. In this work, we propose to represent the road network with a multigraph, so that these alternative routes are considered, and to evaluate how it impacts on solution algorithms and solution values. A simple insertion algorithm is proposed and illustrated in the context of a on-demand transportation system developed in a French area. Computational experiments on academic and realistic data underline the potential cost savings brought by the multigraph model
Use of ultrasonic degradation to study the molecular weight influence of polymeric admixtures for mortars

International audienceThe aim of this paper is to provide a methodology to study the influence of the molecular weight of polysaccharidic admixtures on mortar properties. A wide range of admixtures with different molecular weight and constant structure was prepared. This has been made possible by the use of ultrasonic treatment, a simple, effective, and without additive method. It appears that cellulose and guar gum derivatives, used as water retention agents, exhibit a significant molecular weight reduction according to the ultrasonic treatment duration. The water retention capacity of the mortars mixed with ultrasonically degraded admixture solutions increases with molecular weight for a same admixture. However, comparing water retention values obtained with similar molecular weight of a same family shows that effectiveness of polysaccharides as water retention agent is not linearly linked to their molecular weight
Quantification of nanoparticle endocytosis based on double fluorescent pH-sensitive nanoparticles

International audienceAmorphous silica is a particularly interesting material because of its inertness and chemical stability. Silica nanoparticles have been recently developed for biomedical purposes but their innocuousness must be carefully investigated before clinical use. The relationship between nanoparticles physicochemical features, their uptake by cells and their biological activity represents a crucial issue, especially for the development of nanomedicine. This work aimed at adapting a method for the quantification of nanoparticle endocytosis based on pH-sensitive and double fluorescent particles. For that purpose, silica nanoparticles containing two fluorophores: FITC and pHrodoTM were developed, their respective fluorescence emission depends on the external pH. Indeed, FITC emits a green fluorescence at physiological pH and pHrodoTM emits a red fluorescence which intensity increased with acidification. Therefore, nanoparticles remained outside the cells could be clearly distinguished from nanoparticles uptaken by cells as these latter could be spotted inside cellular acidic compartments (such as phagolysosomes, micropinosomes...). Using this model, the endocytosis of 60 nm nanoparticles incubated with the RAW 264.7 macrophages was quantified using time-lapse microscopy and compared to that of 130 nm submicronic particles. The amount of internalized particles was also evaluated by fluorimetry. The biological impact of the particles was also investigated in terms of cytotoxicity, pro-inflammatory response and oxidative stress. Results clearly demonstrated that nanoparticles were more uptaken and more reactive than submicronic particles. Moreover, we validated a method of endocytosis quantification
Impacts of Mayan land use on Laguna Tusp an watershed (Pet en, Guatemala) as seen through clay and ostracode analysis

International audienceMost of the cities built by the Mayas in the Pet en area, in the Central Yucat an Peninsula, were abandoned 1200 to 1000 years ago. The phenomenon is sometimes un-appropriately called " the collapse of the Maya civilization ". Its main causes are still debated, ranging from climatic according to the occurrence of severe or modest droughts, to societal in the form of environmental mismanagement of the environment. In both processes, it is inferred that stress triggered the formation in many Pet en lake sediments of erosional clay deposits, known as 'Maya clays'. This work presents a high resolution, multi-proxy study of 'Maya clays' in lacustrine sediments from Laguna Tusp an, near the archaeological site of La Joyanca. Micropaleontological (ostracodes), mineral-ogical (clay minerals) and geochemical (bulk elemental composition and stable isotopes in organic carbon) records reveal three different phases of soil erosion throughout the last 5300 years. The oldest phase from 5281 to 2998 cal yr BP (i.e. 3331 e 1048 BC) is characterized by successive natural and moderate soil erosion deposits which follow climatic variations recorded in the American tropical belt. The time interval between 2998 and 1281 cal yr BP (i.e. 1048 BC and AD 661) contains four distinct erosional layers which, according to clay mineralogy, are indicative of both increased erosion of the regolith and strong soil loss. The most recent, also the most massive, deposit of Maya clay ends around 1281 cal yr BP (AD 661), that is some 200 years before the so-called 'Maya collapse' in the Pet en area. Recent archeological fieldwork studies indicate that a population mobility took place into the city of La Joyanca from its hinterland by the early Late Classic Period (ca. AD 600), that is, at the end or just after this erosion episode, and well before the occurrence of the Terminal Classic-Postclassic (AD 800e1250) drastic climatic changes. Shifts in environmental management by the local society and timing of urbanization may explain environmental changes better than droughts per se
Phase Equilibrium Constraints on Pre-eruptive Conditions of Recent Felsic Explosive Volcanism at Pantelleria Island, Italy

International audienceWe present experimental phase equilibria carried out on a pantelleritic bulk-rock composition with a peralkalinity index [PI = molar (Na2O + K2O)/Al2O3] = 1*4, which is representative of the most energetic pumice fall eruption of the resurgent post-caldera volcanism on Pantelleria island. For the explored conditions (P = 25-150 MPa; T = 680-800°C; H2Omelt up to 6 wt %; fO2 ≤ NNO, where NNO is nickel-nickel oxide buffer) clinopyroxene is the liquidus phase followed by alkali feldspar and then quartz. The crystallization of amphibole is limited to temperatures below 700°C. Aenigmatite crystallizes near the liquidus for P ≥ 100 MPa. When clinopyroxene is the sole liquidus phase, the coexisting melt is characterized by a decrease in peralkalinity index to 1*2, if compared with the starting material, approaching comendite composition. In contrast, when alkali feldspar joins the liquidus phase assemblage, residual melts become extremely peralkaline (PI = 3*2), with FeO contents in excess of 14 wt %. Comparison of our experiments with natural phase abundances and compositions constrains the depth of the Fastuca pantellerite reservoir to be around 5 ± 1 km (or P = 120 ± 20 MPa) at T = 730 ± 10°C, with H2Omelt around 4 wt %, and fO2 1*5 log unit below NNO. Such conditions correspond to the dominant phase assemblage of feldspar, clinopyroxene and aenigmatite. Amphibole occurrence requires both higher melt water contents and lower temperatures (up to 6*5 wt % at 680°C), and may reflect provenance from a deeper and wetter portion of the tapped reservoir. In contrast, quartz is more probably related to crystallization during magma ascent, which explains the lower melt water content of its melt inclusions. Overall, the results confirm that pantellerites may be both water-rich and reduced magmas. These characteristics imply that any coexisting fluid phase in the reservoir will be dominated by water and hydrogen species, the latter amounting to a few mole per cent. Magma unrest at Pantelleria may thus be heralded by emissions of hydrous and reduced gases (i.e. CO2-poor and H2-rich), if the present-day reservoir is felsic in composition
The Achromatic Interfero Coronagraph

We report on the Achromatic Interfero Coronagraph, a focal imaging device which aims at rejecting the energy contribution of a point-like source set on-axis, so as to make detectable its angularly-close environment (applicable to stellar environment: circumstellar matter, faint companions, planetary systems, but also conceivably to Active Galatic Nucleii and multiple asteroids). With AIC, starlight rejection is based on destructive interference, which allows exploration of the star's neighbouring at angular resolution better than the diffraction limit of the hosting telescope. Thanks to the focus crossing property of light, rejection is achromatic thus yielding a large spectral bandwidth of work. Descriptions and comments are given regarding the principle, the device itself, the constraints and limitations, and the theoretical performance. Results are presented which demonstrate the close-sensing capability and which show images of a companion obtained in laboratory and 'on the sky' as well. A short pictorial description of alternative AIC concepts, CIAXE and Open-Air CIAXE, currently under study, is given
An experimental study of intermodulation effects in an atomic fountain frequency standard

International audienceThe short-term stability of passive atomic frequency standards, especially in pulsed operation, is often limited by local oscillator noise via intermodulation effects. We present an experimental demonstration of the intermodulation effect on the frequency stability of a continuous atomic fountain clock where, under normal operating conditions, it is usually too small to observe. To achieve this, we deliberately degrade the phase stability of the microwave field interrogating the clock transition. We measure the frequency stability of the locked, commercial-grade local oscillator, for two modulation schemes of the microwave field: square-wave phase modulation and square-wave frequency modulation. We observe a degradation of the stability whose dependence with the modulation frequency reproduces the theoretical predictions for the intermodulation effect. In particular no observable degradation occurs when this frequency equals the Ramsey linewidth. Additionally we show that, without added phase noise, the frequency instability presently equal to 2x10-13 at 1s, is limited by atomic shot-noise and therefore could be reduced were the atomic flux increased
Direct sediment transfer from land to deep-sea: Insights into shallow multibeam bathymetry at La Réunion Island

International audienceSubmarine canyon heads are key areas for understanding the triggering factors of gravity currents responsible for the transfer of detrital sediment to the deep basins. This contribution offers a detailed picture of canyon heads off La Réunion Island, with high-resolution multibeam bathymetry in the water depth range of 4-220 m. The present feeding of the Cilaos turbidite system, one of the largest modern volcaniclastic systems in the world, is deduced from morphological and sedimentological interpretations of newly acquired data. The study highlights small-scale sedimentary features indicating hydrodynamic and sedimentary processes. A direct connexion between the Saint-Etienne river mouth and submarine canyons is evidenced by the complete incision of the shelf and the presence of canyon heads connected to the modern deltaic bar. This direct connection, supplied by river torrential floods (cyclonic floods every two or three years), suggests the continuity of high-density fluvial flows to submarine gravity flows, forming hyperpycnal flows in the canyon. The initiation of secondary submarine gravity flows by storm waves (large austral waves and cyclonic waves) is also proposed for submarine canyons with large canyon heads developed in the surf zone from a sandy coastal bar. Bedforms in active canyon axis are considered as an indicator of the frequent activity of high-density turbidity currents. Moreover, a morphological record of last glacial and deglacial sea level variations is preserved, and particularly the Last Glacial Maximum sea level with the presence of small vertical cliffs, observed in this bathymetric data, which likely corresponds to a paleo-shoreline or paleo-reefs
High-speed >90% quantum-efficiency p–i–n photodiodes with a resonance wavelength adjustable in the 795–835 nm range

Cataloged from PDF version of article.We report GaAs/AlGaAs-based high-speed, high-efficiency, resonant cavity enhanced p–i–nphotodiodes. The devices were fabricated by using a microwave-compatible fabrication process. By using a postprocess recess etch, we tuned the resonance wavelength from 835 to 795 nm while keeping the peak efficiencies above 90%. The maximum quantum efficiency was 92% at a resonance wavelength of 823 nm. The photodiode had an experimental setup-limited temporal response of 12 ps. When the system response is deconvolved, the 3 dB bandwidth corresponds to 50 GHz, which is in good agreement with our theoretical calculations.
© 1999 American Institute of Physic
Global cost estimates of reducing carbon emissions through avoided deforestation

Tropical deforestation is estimated to cause about one-quarter of anthropogenic carbon emissions, loss of biodiversity, and other environmental services. United Nations Framework Convention for Climate Change talks are now considering mechanisms for avoiding deforestation (AD), but the economic potential of AD has yet to be addressed. We use three economic models of global land use and management to analyze the potential contribution of AD activities to reduced greenhouse gas emissions. AD activities are found to be a competitive, low-cost abatement option. A program providing a 10% reduction in deforestation from 2005 to 2030 could provide 0.3-0.6 Gt (1 Gt = 1 x 10^5 g) CO2/yr in emission reductions and would require $0.4 billion/yr to $1.7 billion/yr for 30 years. A 50% reduction in deforestation from 2005 to 2030 could provide 1.5-2.7 Gt CO2/yr in emission reductions and would require $17.2 billion/yr to $28.0 billion/yr. Finally, some caveats to the analysis that could increase costs of AD programs are described
The molecular structure of melts along the carbonatite–kimberlite–basalt compositional joint: CO2and polymerisation

International audienceTransitional melts, intermediate in composition between silicate and carbonate melts, form by low degree partial melting of mantle peridotite and might be the most abundant type of melt in the asthenosphere. Their role in the transport of volatile elements and in metasomatic processes at the planetary scale might be significant yet they have remained largely unstudied. Their molecular structure has remained elusive in part because these melts are difficult to quench to glass. Here we use FTIR, Raman, 13C and 29Si NMR spectroscopy together with First Principle Molecular Dynamic (FPMD) simulations to investigate the molecular structure of transitional melts and in particular to assess the effect of CO2on their structure. We found that carbon in these glasses forms free ionic carbonate groups attracting cations away from their usual ‘depolymerising’ role in breaking up the covalent silicate network. Solution of CO2in these melts strongly modifies their structure resulting in a significant polymerisation of the aluminosilicate network with a decrease in NBO/Si of about 0.2 for every 5 mol% CO2dissolved.This polymerisation effect is expected to influence the physical and transport properties of transitional melts. An increase in viscosity is expected with increasing CO2content, potentially leading to melt ponding at certain levels in the mantle such as at the lithosphere–asthenosphere boundary. Conversely an ascending and degassing transitional melt such as a kimberlite would become increasingly fluid during ascent hence potentially accelerate. Carbon-rich transitional melts are effectively composed of two sub-networks:a carbonate and a silicate one leading to peculiar physical and transport properties
The powerful in vitro bioactivity of Euterpe oleracea Mart. seeds and related phenolic compounds

The Euterpe oleracea Mart. (açaí) is a plant from the Amazon region, classified as
"super fruit" because of its various functional properties. However, limited investigation
has been performed on açaí by-products, such as seeds. Therefore, the aim of this work
was to characterized the phenolic compounds of the aqueous extract of açaí seeds and
further evaluate its bioactivity (antioxidant and cytotoxic activities. Only
proanthocyanidins were detected, being a B-type (epi)catechin tetramer the most
abundant; however, procyanidin trimmers were the most predominant form. Açaí seeds
extract revealed a high antioxidant (EC50 ranging from 3.6 to 19.4 μg/mL) and cytotoxic
activity, being more effective in the cervical carcinoma cell line (HeLa; GI50 = 18
μg/mL); it did not show toxicity for non-tumor cells. Açaí seeds are considered a waste
and could have an added economic benefit, through the extraction of natural
antioxidants, particularly proanthocyanidins, that could find applications in food and
pharmaceutical industries.The authors are grateful to Foundation for Science and Technology (FCT, Portugal) for 
financial support to the research centre CIMO (strategic project PEst
OE/AGR/UI0690/2011) and L. Barros researcher contract under “Programa 
Compromisso com Ciência - 2008”. The authors are also grateful to Jamil S. Oliveira by 
the initial discussions on the preparation of samples
Metabolic monitoring of advanced uterine cervical cancer neoadjuvant chemotherapy by using [F-18]-Fluorodeoxyglucose positron emission tomography: preliminary results in three patients

[Objective]
The aim of this report is to describe the potential clinical utility of tracer [F-18]-Fluorodeoxyglucose (FDG) uptake, quantitated as a standardized uptake value (SUV) by positron emission tomography (PET), to evaluate treatment response to neoadjuvant chemotherapy (NAC) in advanced uterine cervical cancer.

[Methods]
We briefly describe the clinical courses of three women with advanced cervical cancer who were treated with neoadjuvant chemotherapy (NAC) prior to radical hysterectomy and who were analyzed for correlation with the decrease in tumor volume by magnetic resonance imaging (MRI), in SUV by FDG-PET, and by histologic response.

[Results]
In these individuals, tumor volume and SUV were decreased by NAC. The decrease in SUV by FDG-PET was better correlated to histologic response for NAC than MRI was in advanced cervical cancer.

[Conclusions]
Measurement of SUV by FDG-PET has clinical utility in evaluating treatment response for NAC in advanced cervical cancer. Although work in this field is still in the early stages, this report demonstrates that SUV by FDG-PET has the potential to become the new standard for monitoring the treatment response of NAC in cervical cancer. This monitoring approach must be proven in a larger number of patients for both primary and secondary lesions and should be further explored in another gynecologic cancer
Development of 394.6 GHz CW Gyrotron (Gyrotron FU CW II) for DNP/Proton-NMR at 600 MHz

Gyrotron FU CW II with an 8 T liquid He free superconducting magnet, the second gyrotron of the THz Gyrotron FU CW Series, has been constructed and the operation test was successfully carried out. It will be used for enhancing the sensitivity of 600 MHz proton-NMR by use of Dynamic Nuclear Polarization (DNP). The designed operation mode of the gyrotron is TE2,6 at the second harmonic. The corresponding frequency is 394.6 GHz. The real operation frequency is 394.3 GHz at TE06 mode, because of fabrication error of the diameter of the cavity. The operation is in complete CW at the output power of around 30 W or higher at the TE06 cavity mode. There are many other operation modes at the fundamental and the second harmonic. Typical output power of the fundamental and the second harmonic are higher than 100 W and 20 W, respectively. The highest frequency observed up to the present is 443.5 GHz at the second harmonic operation of TE6,5 mode. The measured results are compared with the theoretical consideration
Points to consider for prioritizing clinical genetic testing services: a European consensus process oriented at accountability for reasonableness.

Given the cost constraints of the European health-care systems, criteria are needed to decide which genetic services to fund from the public budgets, if not all can be covered. To ensure that high-priority services are available equitably within and across the European countries, a shared set of prioritization criteria would be desirable. A decision process following the accountability for reasonableness framework was undertaken, including a multidisciplinary EuroGentest/PPPC-ESHG workshop to develop shared prioritization criteria. Resources are currently too limited to fund all the beneficial genetic testing services available in the next decade. Ethically and economically reflected prioritization criteria are needed. Prioritization should be based on considerations of medical benefit, health need and costs. Medical benefit includes evidence of benefit in terms of clinical benefit, benefit of information for important life decisions, benefit for other people apart from the person tested and the patient-specific likelihood of being affected by the condition tested for. It may be subject to a finite time window. Health need includes the severity of the condition tested for and its progression at the time of testing. Further discussion and better evidence is needed before clearly defined recommendations can be made or a prioritization algorithm proposed. To our knowledge, this is the first time a clinical society has initiated a decision process about health-care prioritization on a European level, following the principles of accountability for reasonableness. We provide points to consider to stimulate this debate across the EU and to serve as a reference for improving patient management
Dynamic replication strategies in data grid systems: a survey

In data grid systems, data replication aims to increase availability, fault tolerance, load balancing and scalability while reducing bandwidth consumption, and job execution time. Several classification schemes for data replication were proposed in the literature, (i) static vs. dynamic, (ii) centralized vs. decentralized, (iii) push vs. pull, and (iv) objective function based. Dynamic data replication is a form of data replication that is performed with respect to the changing conditions of the grid environment. In this paper, we present a survey of recent dynamic data replication strategies. We study and classify these strategies by taking the target data grid architecture as the sole classifier. We discuss the key points of the studied strategies and provide feature comparison of them according to important metrics. Furthermore, the impact of data grid architecture on dynamic replication performance is investigated in a simulation study. Finally, some important issues and open research problems in the area are pointed out