pinecone/core-2020-05-10-deduplication huggingface dataset:
Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.

Background:The human epidermal growth factor receptor (EGFR) is an important therapeutic target in oncology, and three different types of EGFR inhibitors have been approved for the treatment of cancer patients. However, there has been no clear association between the expression levels of EGFR protein in the tumours determined by the FDA-approved EGFR PharmDx kit (Dako) or other standard anti-EGFR antibodies and the response to the EGFR inhibitors.Method:In this study, we investigated the potential of our anti-EGFR monoclonal antibodies (mAbs; ICR9, ICR10, ICR16) for immunohistochemical diagnosis of wild-type EGFR and/or the type-III deletion mutant form of EGFR (EGFRvIII) in formalin-fixed, paraffin-embedded human tumour specimens.Results:We found that the anti-EGFR mAb in the EGFR PharmDx kit stained both wild-type and EGFRvIII-expressing cells in formalin-fixed, paraffin-embedded sections. This pattern of EGFR immunostaining was also found with our anti-EGFR mAb ICR16. In contrast, mAbs ICR10 and ICR9 were specific for the wild-type EGFR.Conclusion:We conclude that mAbs ICR9 and ICR10 are ideal tools for investigating the expression patterns of wild-type EGFR protein in tumour specimens using immunohistochemistry, and to determine their prognostic significance, as well as predictive value for response to therapy with EGFR antibodies.British Journal of Cancer advance online publication, 7 February 2012; doi:10.1038/bjc.2012.27 www.bjcancer.com
A quantum-inspired version of the nearest mean classifier

We introduce a framework suitable for describing standard classification problems using the mathematical language of quantum states. In particular, we provide a one-to-one correspondence between real objects and pure density operators. This correspondence enables us: (1) to represent the nearest mean classifier (NMC) in terms of quantum objects, (2) to introduce a quantum-inspired version of the NMC called quantum classifier (QC). By comparing the QC with the NMC on different datasets, we show how the first classifier is able to provide additional information that can be beneficial on a classical computer with respect to the second classifier
More relational refinement: traces and partial relations

Data refinement in a state-based language such as Z is defined using a relational model in terms of the behaviour of abstract programs. Downward and upward simulation conditions form a sound and jointly complete methodology to verify relational data refinements. On the other hand, refinement in a process algebra takes a number of different forms depending on the exact notion of observation chosen, which can include the events a system is prepared to accept or refuse. In this paper we continue our program of deriving relational simulation conditions for process algebraic refinement by defining further embeddings into our relational model: traces, completed traces, failure traces and extension
The appropriateness of default investment options in defined contribution plans : Australian evidence

For participants in defined contribution (DC) plans who refrain from exercising investment choice, plan contributions are invested following the default investment option of their respective plans. Since default investment options of different plans vary widely in terms of their benchmark asset allocation, the most important determinant of investment performance, participants enrolled in these options face significantly different wealth outcomes at retirement. This paper simulates the terminal wealth outcomes under different static asset allocation strategies to evaluate their relative appeal as default investment choice in DC plans. We find that strategies with low or moderate allocation to stocks are consistently outperformed in terms of upside potential of exceeding the participant’s wealth accumulation target at retirement as well as downside risk of falling below that target outcome by aggressive strategies whose allocation to stocks approach 100%. The risk of extremely adverse wealth outcomes for plan participants also does not appear to be very sensitive to asset allocation. Our evidence suggests the appropriateness of strategies heavily tilted towards stocks to be nominated as default investment options in DC plans unless plan providers emphasize predictability of wealth outcomes over adequacy of retirement wealth
Terahertz detection schemes based on sequential multiphoton absorption

We present modeling and simulation of prototypical multi-bound-state quantum-well infrared photodetectors and show that such a detection design may overcome the problems arising when the operation frequency is pushed down into the far infrared spectral region. In particular, after a simplified analysis on a parabolic-potential design, we propose a fully three-dimensional model based on a finite-difference solution of the Boltzmann transport equation for realistic potential profiles. The performances of the proposed simulated devices are encouraging and support the idea that such design strategy may face the well-known dark current proble
N-terminal amino acid sequences of chloroform/methanol-soluble proteins and albumins from endosperms of wheat, barley and related species: Homology with inhibitors of α-amylase and trypsin and with 2 S storage globulins

The N-terminal amino acid sequences of two chloroform/methanol soluble globulins from barley and one form wheat are reported. They are homologous with N-terminal sequences previously reported for α-amylase and trypsin inhibitors from cereals and 2 S storage proteins from castor bean and rape. Three albumins were also purified from Aegilops squarrosa and Triticum monococcum. These had N-terminal amino acid sequences most closely related to the α-amylase and trypsin inhibitors. The relationships of this superfamily of seed proteins are discussed
In-season calcium-spray formulations improve calcium balance and fruit quality traits of peach.

Experiments to evaluate the effect of in-season calcium (Ca) sprays on late-season peach (Prunus persica L. Batsch cv. Calrico) were carried out for a 2-year period. Calcium formulations (0.5% and 1.0% in 2008 and only 0.5% tested in 2009) supplied either as CaCl2 or Ca propionate in combination with two or three adjuvants (0.05% of the nonionic surfactants Tween 20 and Break Thru, and 0.5% carboxymethylcellulose, CMC) were sprayed four to five times over the growing season. Peach mesocarp and endocarp Ca concentrations were determined on a 15-day basis from the beginning of May until the end of June. Further tissue analyses were performed at harvest. A decreasing trend in fruit Ca concentrations over the growing season was always observed regardless of the Ca treatments. Both in 2008 and 2009, significant tissue Ca increments associated with the application of Ca-containing sprays in combination with adjuvants were only observed in June, which may be coincident with the period of pit hardening. In 2008, both at harvest and after cold storage, the total soluble-solids concentration (° Brix) of fruits supplied with Ca propionate (0.5% and 1.0% Ca) was always lower as compared to the rest of treatments. The application of multiple Ca-containing sprays increased firmness at harvest and after cold storage, especially when CaCl2 was the active ingredient used. Supplying the adjuvants Tween 20 and CMC increased fruit acidity both at harvest and after cold storage. Evaluation of the development of physiological disorders after cold storage (2 weeks at 0°C) indicated a lower susceptibility of Ca-treated fruits to internal browning. Fruits treated with multiple CaCl2-, CMC-, and Break Thru®-containing sprays during the growing season were significantly less prone to the development of chilling injuries as compared to untreated peaches
Mechanical properties of tungsten alloys with Y2O3 and titanium additions

In this research the mechanical behaviour of pure tungsten (W) and its alloys (2 wt.% Ti–0.47 wt.% Y2O3 and 4 wt.% Ti–0.5 wt.% Y2O3) is compared. These tungsten alloys, have been obtained by powder metallurgy. The yield strength, fracture toughness and elastic modulus have been studied in the temperature interval of 25 °C to 1000 °C. The results have shown that the addition of Ti substantially improves the bending strength and toughness of W, but it also dramatically increases the DBTT. On the other hand, the addition of 0.5% Y2O3, is enough to improve noticeably the oxidation behaviour at the higher temperatures. The grain size, fractography and microstructure are studied in these materials. Titanium is a good grain growth inhibitor and effective precursor of liquid phase in HIP. The simultaneous presence of Y2O3 and Ti permits to obtain materials with low pores presenc
On the role of unobserved preference heterogeneity in discrete choice models of labor supply

The aim of this paper is to analyse the role of unobserved preference heterogene- ity in structural discrete choice models of labor supply. Within this framework, unobserved heterogeneity has been estimated either parametrically or nonpara- metrically through random coefficient models. Nevertheless, the estimation of such models by means of standard, gradient-based methods is often difficult, in particular if the number of random parameters is high. For this reason, the role of unobserved taste variability in empirical studies is often constrained since only a small set of coefficients is assumed to be random. However, this simplification may affect the estimated labor supply elasticities and the subsequent policy pre- scriptions. In this paper, we propose a new estimation method based on an EM algorithm that allows us to fully consider the effect of unobserved heterogeneity nonparametrically. Results show that labor supply elasticities and policy prescrip- tions do change significantly only when the full set of coefficients is assumed to be random. Moreover, we analyse the behavioural effects of the introduction of a working-tax credit scheme in the Italian tax-benefit system and show that the magnitude of labor supply reactions and the post-reform income distribution can differ significantly depending on the specification of unobserved heterogeneity.
Effects of Economic Development in China on Skill-Biased Technical Change in the US

In this study, we analyze the effects of a decrease in unskilled labor in China on the direction of innovation in the US by incorporating production offshoring into a North-South model of directed technical change. We find that if offshoring is present (absent) in equilibrium, then a decrease in unskilled labor in the South would lead to
skill-biased (unskill-biased) technical change in the North. This finding highlights the different implications of offshoring and conventional trade on innovation. Furthermore, we find that an increase in the Southern stock of capital reduces offshoring and also leads to skill-biased technical change. Therefore, rapid capital accumulation and a decrease in unskilled labor in China could both lead to a rising skill premium in the US. Calibrating the model to China-US data, we find that a 1% decrease in unskilled labor (1% increase in capital) in China leads to a 0.8% (0.6%) increase in the skill premium in the US under a moderate elasticity of substitution between skill-intensive and labor-intensive goods.
Effect of phospholipids and bile acids on cholesterol nucleation time and vesicular/micellar cholesterol in gallbladder bile of patients with cholesterol stones

Supersaturation and rapid nucleation of cholesterol in bile are of key importance in the pathogenesis of cholesterol gallstones. While the effects of bile acids and phospholipids on cholesterol saturation of bile have been extensively studied, their influence on the cholesterol nucleation time has not been compared. We, therefore, investigated whether increases of bile acid or phospholipid concentrations in bile by in vitro supplementation affect the cholesterol nucleation time. Bile samples were obtained at surgery from patients with cholesterol gallstones. Prior to the nucleation assay the bile samples were divided into 0.5-ml aliquots and supplemented with 1.25, 2.5, 5.0, and 10.0 mumol/ml of different phosphatidylcholines (PC-dimyristoyl, PC- dipalmitoyl, PC-distearoyl, and extracted biliary PCs) or with 5.0, 10.0, and 20.0 mumol/ml of bile acids (glycine or taurine conjugates of cholic acid, deoxycholic acid, or chenodeoxycholic acid). The increase of phosphatidylcholine or bile acid concentration decreased the mean cholesterol saturation index to a similar extent (PC: 0.1-0.3; BA: 0.1- 0.2). Supplementations of bile with increasing amounts of synthetic or biliary PCs caused a marked prolongation of the nucleation time in bile from 1.5 +/- 0.2 up to > or = 21 days or 2.5 +/- 0.7 up to > or = 21 days. Concurrently, biliary cholesterol was shifted from vesicles to mixed micelles and the cholesterol/phospholipid ratio of the remaining vesicles was progressively lowered. In contrast, the addition of bile acids to gallbladder bile did not affect the cholesterol nucleation time (2.2 +/- 0.3 days), the percentage of vesicular cholesterol, or the cholesterol/phospholipid ratio of vesicles and micelles.
A review of some tribo-dynamics phenomena from micro- to nano-scale conjunctions

The paper provides some highlights in the developments of theories of lubrication and contact mechanics from early pioneering works of Reynolds and Hertz to the establishment of elastohydrodynamic phenomenon by Ertel and Grubin. Some historical discourse is made on the development of elastohydrodynamic theory in the past 6 decades, with particular attention paid to the contact of rolling element bearings. The steady miniaturisation of devices has led to progressively smaller contacts of individual features with lighter load share and diminishing gaps. The ultra-thin films are supported by interaction potentials that significantly deviate from bulk continuum behaviour of lubricating films, with insignificant contributions due to viscous–elastic nature of contacts. Using the same theme of rolling element contacts, the paper highlights the action of some of these dominant forces at close range
An ancient dental gene network regulates development and continuous regeneration of teeth in sharks

The appearance of toothed vertebrates has proven a major determinant of the overall success of this lineage. This is most apparent in sharks and rays (elasmobranchs), which further retain the capacity for life-long tooth regeneration. Given their comparatively basal phylogenetic position, elasmobranchs therefore offer the opportunity for crucial insights into putative ancestral characters of tooth development, yet despite their evolutionary significance this remains poorly understood. Using the established chondrichthyan model, the catshark (Scyliorhinus sp.), we identified the expression of genes representative of conserved signaling pathways during stages of early dental competence, tooth initiation and regeneration. The expression patterns of β-catenin, shh, bmp4, pax9, pitx1/2, and the stem cell marker Sox2, characterise an ancestrally conserved gene set deployed during initiation of the elasmobranch dentition, suggesting that all vertebrate dentitions are defined by the expression of this core set of genes. These findings provide novel evidence to support the conservation in deep evolutionary time of a core set of dental patterning genes, therefore further defining the evolutionary trajectory of tooth development. We show how these genes facilitate the emergence of the shark dentition and offer insights into their deployment during development of the dental lamina, a sheet of dental epithelial cells that are responsible for continuous tooth regeneration.  This study further promotes a specific experimental agenda to further characterise the roles of these core developmental genes during vertebrate tooth development, and importantly dental regeneration
Search for diphoton events with large missing transverse momentum in 1 fb(-1) of 7 TeV proton-proton collision data with the ATLAS detector ATLAS Collaboration

A search for diphoton events with large missing transverse momentum has been performed using 1.07 fb−11.07 fb−1 of proton–proton collision data at View the MathML sources=7 TeV recorded with the ATLAS detector. No excess of events was observed above the Standard Model prediction and 95% Confidence Level (CL) upper limits are set on the production cross section for new physics. The limits depend on each model parameter space and vary as follows: σ<(22–129) fbσ<(22–129) fb in the context of a generalised model of gauge-mediated supersymmetry breaking (GGM) with a bino-like lightest neutralino, σ<(27–91) fbσ<(27–91) fb in the context of a minimal model of gauge-mediated supersymmetry breaking (SPS8), and σ<(15–27) fbσ<(15–27) fb in the context of a specific model with one universal extra dimension (UED). A 95% CL lower limit of 805 GeV805 GeV, for bino masses above 50 GeV, is set on the GGM gluino mass. Lower limits of 145 TeV145 TeV and 1.23 TeV1.23 TeV are set on the SPS8 breaking scale Λ   and on the UED compactification scale 1/R1/R, respectively. These limits provide the most stringent tests of these models to date.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; ARTEMIS, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNAS, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT, Greece; ISF, MINERVA, GIF, DIP and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America.info:eu-repo/semantics/publishedVersio
Search for new phenomena in high-mass diphoton final states using 37 fb−1 of proton–proton collisions collected at s=13 TeV with the ATLAS detector

© 2017 The Author(s) Searches for new phenomena in high-mass diphoton final states with the ATLAS experiment at the LHC are presented. The analysis is based on pp collision data corresponding to an integrated luminosity of 36.7 fb −1 at a centre-of-mass energy s=13 TeV recorded in 2015 and 2016. Searches are performed for resonances with spin 0, as predicted by theories with an extended Higgs sector, and for resonances with spin 2, using a warped extra-dimension model as a benchmark model, as well as for non-resonant signals, assuming a large extra-dimension scenario. No significant deviation from the Standard Model is observed. Upper limits are placed on the production cross section times branching ratio to two photons as a function of the resonance mass. In addition, lower limits are set on the ultraviolet cutoff scale in the large extra-dimensions model.OIT -Ontario Innovation Trust(IN2P3-CNRS)info:eu-repo/semantics/publishedVersio
Viscoelastic vibration damping identification methods. Application to laminated glass.

Laminatedglass is composed of two glass layers and a thin intermediate PVB layer, strongly influencing PVB's viscoelastic behaviour its dynamic response. While natural frequencies are relatively easily identified even with simplified FE models, damping ratios are not identified with such an ease. In order to determine to what extent external factors influence dampingidentification, different tests have been carried out. The external factors considered, apart from temperature, are accelerometers, connection cables and the effect of the glass layers. To analyse the influence of the accelerometers and their connection cables a laser measuring device was employed considering three possibilities: sample without instrumentation, sample with the accelerometers fixed and sample completely instrumented. When the sample is completely instrumented, accelerometer readings are also analysed. To take into consideration the effect of the glass layers, tests were realised both for laminatedglass and monolithic samples. This paper presents in depth data analysis of the different configurations and establishes criteria for data acquisition when testing laminatedglass
On the beneficial effect of noise in vertex localization

A theoretical and experimental analysis related to the effect of noise\ud
in the task of vertex identication in unknown shapes is presented. Shapes are\ud
seen as real functions of their closed boundary. An alternative global per-\ud
spective of curvature is examined providing insight into the process of noise-\ud
enabled vertex localization. The analysis reveals that noise facilitates in the\ud
localization of certain vertices. The concept of noising is thus considered and a\ud
relevant global method for localizing Global Vertices is investigated in relation\ud
to local methods under the presence of increasing noise. Theoretical analysis\ud
reveals that induced noise can indeed help localizing certain vertices if com-\ud
bined with global descriptors. Experiments with noise and a comparison to\ud
localized methods validate the theoretical results
Early East Antarctic Ice Sheet growth recorded in the landscape of the Gamburtsev Subglacial Mountains

The Gamburtsev Subglacial Mountains are regarded as a key nucleation site for the Antarctic Ice Sheet and they retain a unique long-term record of pre-glacial and early glacial landscape evolution. Here, we use a range of morphometric analyses to constrain the nature of early glaciation and subsequent ice sheet evolution in the interior of East Antarctica, using a new digital elevation model of the Gamburtsev Subglacial Mountains, derived from an extensive airborne radar survey. We find that an inherited fluvial landscape confirms the existence of the Gamburtsev Subglacial Mountains prior to the onset of glaciation at the Eocene–Oligocene climate boundary (ca. 34 Ma). Features characteristic of glaciation, at a range of scales, are evident across the mountains. High elevation alpine valley heads, akin to cirques, identified throughout the mountains, are interpreted as evidence for early phases of glaciation in East Antarctica. The equilibrium line altitudes associated with these features, combined with information from fossil plant assemblages, suggest that they formed at, or prior to, 34 Ma. It cannot be ruled out that they may have been eroded by ephemeral ice between the Late Cretaceous and the Eocene (100–34 Ma). Hanging valleys, overdeepenings, truncated spurs and steep-sided, linear valley networks are indicative of a more widespread alpine glaciation in this region. These features represent ice growth at, or before, 33.7 Ma and provide a minimum estimate for the scale of the East Antarctic Ice Sheet between ca. 34 and 14 Ma, when dynamic fluctuations in ice extent are recorded at the coast of Antarctica. The implications are that the early East Antarctic Ice Sheet grew rapidly and developed a cold-based core that preserved the alpine landscape. The patterns of landscape evolution identified provide the earliest evidence for the development of the East Antarctic Ice Sheet and can be used to test coupled ice–climate evolution models