pinecone/core-2020-05-10-deduplication huggingface dataset:
Five blood pressure loci identified by an updated genome-wide linkage scan: meta-analysis of the Family Blood Pressure Program.

BACKGROUND: A preliminary genome-wide linkage analysis of blood pressure in the Family Blood Pressure Program (FBPP) was reported previously. We harnessed the power and ethnic diversity of the final pooled FBPP dataset to identify novel loci for blood pressure thereby enhancing localization of genes containing less common variants with large effects on blood pressure levels and hypertension.
METHODS: We performed one overall and 4 race-specific meta-analyses of genome-wide blood pressure linkage scans using data on 4,226 African-American, 2,154 Asian, 4,229 Caucasian, and 2,435 Mexican-American participants (total N = 13,044). Variance components models were fit to measured (raw) blood pressure levels and two types of antihypertensive medication adjusted blood pressure phenotypes within each of 10 subgroups defined by race and network. A modified Fisher's method was used to combine the P values for each linkage marker across the 10 subgroups.
RESULTS: Five quantitative trait loci (QTLs) were detected on chromosomes 6p22.3, 8q23.1, 20q13.12, 21q21.1, and 21q21.3 based on significant linkage evidence (defined by logarithm of odds (lod) score ≥3) in at least one meta-analysis and lod scores ≥1 in at least 2 subgroups defined by network and race. The chromosome 8q23.1 locus was supported by Asian-, Caucasian-, and Mexican-American-specific meta-analyses.
CONCLUSIONS: The new QTLs reported justify new candidate gene studies. They may help support results from genome-wide association studies (GWAS) that fall in these QTL regions but fail to achieve the genome-wide significance
SlideShare presentations, citations, users and trends: A professional site with academic and educational uses

SlideShare is a free social web site that aims to help users to distribute and find presentations. Owned by LinkedIn since 2012, it targets a professional audience but may give value to scholarship through creating a long term record of the content of talks. This article tests this hypothesis by analysing sets of general and scholarly-related SlideShare documents using content and citation analysis and popularity statistics reported on the site. The results suggest that academics, students and teachers are a minority of SlideShare uploaders, especially since 2010, with most documents not being directly related to scholarship or teaching. About two thirds of uploaded SlideShare documents are presentation slides, with the remainder often being files associated with presentations or video recordings of talks. SlideShare is therefore a presentation-centred site with a predominantly professional user base. Although a minority of the uploaded SlideShare documents are cited by, or cite, academic publications, probably too few articles are cited by SlideShare to consider extracting SlideShare citations for research evaluation. Nevertheless, scholars should consider SlideShare to be a potential source of academic and non-academic information, particularly in library and information science, education and business
Search for heavy long-lived charged particles with the ATLAS detector in pp collisions at √s = 7 TeV

A search for long-lived charged particles reaching the muon spectrometer is performed using a data sample of 37 pb[superscript −1] from pp collisions at √s = 7 TeV collected by the ATLAS detector at the LHC in 2010. No excess is observed above the estimated background. Stable [~ over τ] sleptons are excluded at 95% CL up to a mass of 136 GeV, in GMSB models with N[subscript 5] = 3, mmessenger = 250 TeV, sign(μ) = 1 and tanβ = 5. Electroweak production of sleptons is excluded up to a mass of 110 GeV. Gluino R-hadrons in a generic interaction model are excluded up to masses of 530 GeV to 544 GeV depending on the fraction of R-hadrons produced as [~ over g]-balls.European Organization for Nuclear ResearchBrookhaven National LaboratoryUnited States. Dept. of EnergyNational Science Foundation (U.S.
Measurement of the Zγ production cross section in pp collisions at 8 TeV and search for anomalous triple gauge boson couplings

The cross section for the production of Zγ in proton-proton collisions at 8 TeV is measured based on data collected by the CMS experiment at the LHC corresponding to an integrated luminosity of 19.5 fb[superscript −1]. Events with an oppositely-charged pair of muons or electrons together with an isolated photon are selected. The differential cross section as a function of the photon transverse momentum is measured inclusively and exclusively, where the exclusive selection applies a veto on central jets. The observed cross sections are compatible with the expectations of next-to-next-to-leading-order quantum chromodynamics. Limits on anomalous triple gauge couplings of ZZγ and Zγγ are set that improve on previous experimental results obtained with the charged lepton decay modes of the Z boson.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio
Measurement of the CKM angle $\gamma$ using $B^0 \rightarrow D K^{*0}$ with $D \rightarrow K^0_S \pi^+ \pi^-$ decays

A model-dependent amplitude analysis of the decay $B^0\rightarrow D(K^0_S\pi^+\pi^-) K^{*0}$ is performed using proton-proton collision data corresponding to an integrated luminosity of 3.0fb$^{-1}$, recorded at $\sqrt{s}=7$ and $8 TeV$ by the LHCb experiment. The CP violation observables $x_{\pm}$ and $y_{\pm}$, sensitive to the CKM angle $\gamma$, are measured to be \begin{eqnarray*} x_- = -0.15 \pm 0.14 \pm 0.03 \pm 0.01, y_- = 0.25 \pm 0.15 \pm 0.06 \pm 0.01, x_+ = 0.05 \pm 0.24 \pm 0.04 \pm 0.01, y_+ = -0.65^{+0.24}_{-0.23} \pm 0.08 \pm 0.01, \end{eqnarray*} where the first uncertainties are statistical, the second systematic and the third arise from the uncertainty on the $D\rightarrow K^0_S \pi^+\pi^-$ amplitude model. These are the most precise measurements of these observables. They correspond to $\gamma=(80^{+21}_{-22})^{\circ}$ and $r_{B^0}=0.39\pm0.13$, where $r_{B^0}$ is the magnitude of the ratio of the suppressed and favoured $B^0\rightarrow D K^+ \pi^-$ decay amplitudes, in a $K\pi$ mass region of $\pm50 MeV$ around the $K^*(892)^0$ mass and for an absolute value of the cosine of the $K^{*0}$ decay angle larger than $0.4$
Angular analysis and branching fraction measurement of the decay B0 to K*0 mu+ mu-

The angular distributions and the differential branching fraction of the decay B0 to K*(892)0 mu+ mu- are studied using a data sample corresponding to an integrated luminosity of 5.2 inverse femtobarns collected with the CMS detector at the LHC in pp collisions at sqrt(s) = 7 TeV. From more than 400 signal decays, the forward-backward asymmetry of the muons, the K*(892)0 longitudinal polarization fraction, and the differential branching fraction are determined as a function of the square of the dimuon invariant mass. The measurements are in good agreement with standard model predictions
Frontline Dasatinib Treatment in a "Real-Life" Cohort of Patients Older than 65 Years with Chronic Myeloid Leukemia.

Dasatinib (DAS) has been l icensed for the frontline treatment in chronic myeloid leukemia (CML). However, very few data are available regarding its efficacy and toxicity in elderly patients with CML outside clinical trials. To address this issue, we set out a “real-life” cohort of 65 chronic phase CML patients older than 65 years (median age 75.1 years) treated frontline with DAS in 26 Italian centers from June 2012 to June 2015, focusing our attention on toxicity and efficacy data. One third of patients (20/65: 30.7%) had 3 or more comorbidities and required concomitant therapies; according to Sokal classification, 3 patients (4.6%) were low risk, 39 (60.0%) intermediate risk, and 20 (30.8%) high risk, whereas 3 (4.6%) were not classifiable. DAS starting dose was 100 mg once a day in 54 patients (83.0%), whereas 11 patients (17.0%) received less than 100 mg/day. Grade 3/4 hematologic and extrahematologic toxicities were reported in 8 (12.3%) and 12 (18.5%) patients, respectively. Overall, 10 patients (15.4%) permanently discontinued DAS because of toxicities. Pleural effusions (all WHO grades) occurred in 12 patients (18.5%) and in 5 of them occurred during the first 3 months. DAS treatment induced in 60/65 patients (92.3%) a complete cytogenetic response and in 50/65 (76.9%) also a major molecular response. These findings show that DAS might play an important role in the frontline treatment of CML patients >65 years old, proving efficacy and having a favorable safety profile also in elderly subjects with comorbidities
Repeated monitoring as an effective early detection means : first records of naturalised Solidago gigantea Aiton (Asteraceae) in southern Africa

Early detection ofemerging invasive plants depends onmaximizing the probability of detecting newpopulations.
Repeated surveys along a gradient of environmental conditions or in areas exposed to high propagule pressure
provide a potentially efficient strategy for early detection of alien species. The long-term monitoring of such an
area resulted in the documentation of the first naturalised Solidago gigantea Aiton (Asteraceae) population for
southern Africa. This population consisted of c. 45 individuals growing in two locations on unmanaged grassland
in the Drakensberg Mountains at an elevation of 1619 m a.s.l. Solidago gigantea readily invades unmanaged
European grasslands, altering biomass and transforming habitats. Moreover, since goldenrods (Solidago spp)
are perennial species reproducing through a large number of wind-dispersed seeds and belowground rootstocks,
these species appear well pre-adapted to the fire-prone grassland biome of South Africa. We therefore suggest
early-stage eradication of S. gigantea before it potentially becomes an unmanageable and costly invasive species
in this region. This study supports long-termmonitoring programmes as an effective means for early detection of
new invasive species.DST-NRF Centre of Excellence for Invasion Biology, the University of Johannesburg and the University of Pretoria. JMK is currently supported by the long-term research development project no. RVO 67985939 (Academy of Sciences of the Czech
Republic). The MazdaWildlife Fund.http://www.elsevier.com/locate/sajbhb201
Search for W′→tb¯ in the lepton plus jets final state in proton–proton collisions at a centre-of-mass energy of s=8 TeV with the ATLAS detector

AbstractA search for new charged massive gauge bosons, called W′, is performed with the ATLAS detector at the LHC, in proton–proton collisions at a centre-of-mass energy of s=8 TeV, using a dataset corresponding to an integrated luminosity of 20.3 fb−1. This analysis searches for W′ bosons in the W′→tb¯ decay channel in final states with electrons or muons, using a multivariate method based on boosted decision trees. The search covers masses between 0.5 and 3.0 TeV, for right-handed or left-handed W′ bosons. No significant deviation from the Standard Model expectation is observed and limits are set on the W′→tb¯ cross-section times branching ratio and on the W′-boson effective couplings as a function of the W′-boson mass using the CLs procedure. For a left-handed (right-handed) W′ boson, masses below 1.70 (1.92) TeV are excluded at 95% confidence level
Self-quartic interaction for a scalar field in an extended DFR noncommutative space–time

AbstractThe framework of Doplicher–Fredenhagen–Roberts (DFR) for a noncommutative (NC) space–time is considered as an alternative approach to study the NC space–time of the early Universe. Concerning this formalism, the NC constant parameter, θμν, is promoted to coordinate of the space–time and consequently we can describe a field theory in a space–time with extra-dimensions. We will see that there is a canonical momentum associated with this new coordinate in which the effects of a new physics can emerge in the propagation of the fields along the extra-dimensions. The Fourier space of this framework is automatically extended by the addition of the new momenta components. The main concept that we would like to emphasize from the outset is that the formalism demonstrated here will not be constructed by introducing a NC parameter in the system, as usual. It will be generated naturally from an already NC space. We will review that when the components of the new momentum are zero, the (extended) DFR approach is reduced to the usual (canonical) NC case, in which θμν is an antisymmetric constant matrix. In this work we will study a scalar field action with self-quartic interaction ϕ4⋆ defined in the DFR NC space–time. We will obtain the Feynman rules in the Fourier space for the scalar propagator and vertex of the model. With these rules we are able to build the radiative corrections to one loop order of the model propagator. The consequences of the NC scale, as well as the propagation of the field in extra-dimensions, will be analyzed in the ultraviolet divergences scenario. We will investigate about the actual possibility that this kμν conjugate momentum has the property of healing the combination of IR/UV divergences that emerges in this recently new NC spacetime quantum field theory
Global Twisting Motion of Single Molecular KcsA Potassium Channel upon Gating

SummaryIon channels are signal transduction molecules that switch ion permeation pathways on and off (gating). Crystal structures of several kinds of potassium channels have revealed open and closed conformations, which provide static pictures of gating status. Here we studied KcsA potassium channels undergoing conformational changes at the single-molecule level. A KcsA channel with a gold nanocrystal attached was irradiated by white X-rays and motions of the diffraction spot from the nanocrystal were tracked in real time. Upon gating, the KcsA channels twisted around the axis of the pore. These conformational changes were prevented by an open-channel blocker, tetrabuthylammonium. Random clockwise and counterclockwise twisting in the range of several tens of degrees originated in the transmembrane domain and was transmitted to the cytoplasmic domain. This coupling suggests a mechanical interplay between the transmembrane and cytoplasmic domains
Rapid measurement of 8-oxo-7,8-dihydro-2′-deoxyguanosine in human biological matrices using ultra-high-performance liquid chromatography–tandem mass spectrometry

AbstractInteraction of reactive oxygen species with DNA results in a variety of modifications, including 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), which has been extensively studied as a biomarker of oxidative stress. Oxidative stress is implicated in a number of pathophysiological processes relevant to obstetrics and gynecology; however, there is a lack of understanding as to the precise role of oxidative stress in these processes. We aimed to develop a rapid, validated assay for the accurate quantification of 8-oxodG in human urine using solid-phase extraction and ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) and then investigate the levels of 8-oxodG in several fluids of interest to obstetrics and gynecology. Using UHPLC–MS/MS, 8-oxodG eluted after 3.94min with an RSD for 15 injections of 0.07%. The method was linear between 0.95 and 95nmol/L with LOD and LOQ of 5 and 25fmol on-column, respectively. Accuracy and precision were 98.7–101.0 and <10%, respectively, over three concentrations of 8-oxodG. Recovery from urine was 88% with intra- and interday variations of 4.0 and 10.2%, respectively. LOQ from urine was 0.9pmol/ml. Rank order from the greatest to lowest 8-oxodG concentration was urine>seminal plasma>amniotic fluid>plasma>serum>peritoneal fluid, and it was not detected in saliva. Urine concentrations normalized to creatinine (n=15) ranged between 0.55 and 1.95pmol/μmol creatinine. We describe, for the first time, 8-oxodG concentrations in human seminal plasma, peritoneal fluid, amniotic fluid, and breast milk, as well as in urine, plasma, and serum, using a rapid UHPLC–MS/MS method that will further facilitate biomonitoring of oxidative stress
Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

AbstractThere is a substantial need to develop new medicines against parasitic diseases via public-private partnerships. Based on high throughput phenotypic screens of largely protozoal pathogens and bacteria, the Medicines for Malaria Venture (MMV) has recently assembled an open-access ‘Pathogen Box’ containing 400 well-curated chemical compounds. In the present study, we tested these compounds for activity against parasitic stages of the nematode Haemonchus contortus (barber's pole worm). In an optimised, whole-organism screening assay, using exsheathed third-stage (xL3) and fourth-stage (L4) larvae, we measured the inhibition of larval motility, growth and development of H. contortus. We also studied the effect of the ‘hit’ compound on mitochondrial function by measuring oxygen consumption. Among the 400 Pathogen Box compounds, we identified one chemical, called tolfenpyrad (compound identification code: MMV688934) that reproducibly inhibits xL3 motility as well as L4 motility, growth and development, with IC50 values ranging between 0.02 and 3 μM. An assessment of mitochondrial function showed that xL3s treated with tolfenpyrad consumed significantly less oxygen than untreated xL3s, which was consistent with specific inhibition of complex I of the respiratory electron transport chain in arthropods. Given that tolfenpyrad was developed as a pesticide and has already been tested for absorption, distribution, excretion, biotransformation, toxicity and metabolism, it shows considerable promise for hit-to-lead optimisation and/or repurposing for use against H. contortus and other parasitic nematodes. Future work should assess its activity against hookworms and other pathogens that cause neglected tropical diseases
Measurement of colour flow with the jet pull angle in tt¯ events using the ATLAS detector at s=8 TeV

AbstractThe distribution and orientation of energy inside jets is predicted to be an experimental handle on colour connections between the hard-scatter quarks and gluons initiating the jets. This Letter presents a measurement of the distribution of one such variable, the jet pull angle. The pull angle is measured for jets produced in tt¯ events with one W boson decaying leptonically and the other decaying to jets using 20.3 fb−1 of data recorded with the ATLAS detector at a centre-of-mass energy of s=8 TeV at the LHC. The jet pull angle distribution is corrected for detector resolution and acceptance effects and is compared to various models
Comparison of optimal performance at 300keV of three direct electron detectors for use in low dose electron microscopy

AbstractLow dose electron imaging applications such as electron cryo-microscopy are now benefitting from the improved performance and flexibility of recently introduced electron imaging detectors in which electrons are directly incident on backthinned CMOS sensors. There are currently three commercially available detectors of this type: the Direct Electron DE-20, the FEI Falcon II and the Gatan K2 Summit. These have different characteristics and so it is important to compare their imaging properties carefully with a view to optimise how each is used. Results at 300keV for both the modulation transfer function (MTF) and the detective quantum efficiency (DQE) are presented. Of these, the DQE is the most important in the study of radiation sensitive samples where detector performance is crucial. We find that all three detectors have a better DQE than film. The K2 Summit has the best DQE at low spatial frequencies but with increasing spatial frequency its DQE falls below that of the Falcon II
NAD(H)-coupled hydrogen cycling – structure–function relationships of bidirectional [NiFe] hydrogenases

AbstractHydrogenases catalyze the activation or production of molecular hydrogen. Due to their potential importance for future biotechnological applications, these enzymes have been in the focus of intense research for the past decades. Bidirectional [NiFe] hydrogenases are of particular interest as they couple the reversible cleavage of hydrogen to the redox conversion of NAD(H). In this account, we review the current state of knowledge about mechanistic aspects and structural determinants of these complex multi-cofactor enzymes. Special emphasis is laid on the oxygen-tolerant NAD(H)-linked bidirectional [NiFe] hydrogenase from Ralstonia eutropha
Blind source separation aided characterization of the γ′ strengthening phase in an advanced nickel-based superalloy by spectroscopic 4D electron microscopy

AbstractThe γ′ strengthening phase in an advanced nickel-based superalloy, ATI 718Plus, was characterized using a blind source separation applied to a four dimensional X-ray microanalysis dataset obtained by scanning transmission electron microscopy. Selected patterns in the X-ray spectra identified by independent component analysis were found to be spatially and chemically representative of the matrix (γ) and precipitate phases (γ′) present in the superalloy, enabling their size, shape and distribution to be determined. The three dimensional chemical reconstruction of the microstructure may provide insight into the role of the various alloying elements in the evolution of the microstructure at the nano-scale
Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

SummaryInterleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β activation is regulated by inhibitor of apoptosis (IAP) proteins, we treated macrophages with an IAP-antagonist “Smac mimetic” compound or genetically deleted the genes that encode the three IAP family members cIAP1, cIAP2, and XIAP. After Toll-like receptor priming, IAP inhibition triggered cleavage of IL-1β that was mediated not only by the NLRP3-caspase-1 inflammasome, but also by caspase-8 in a caspase-1-independent manner. In the absence of IAPs, rapid and full generation of active IL-1β by the NLRP3-caspase-1 inflammasome, or by caspase-8, required the kinase RIP3 and reactive oxygen species production. These results demonstrate that activation of the cell death-inducing ripoptosome platform and RIP3 can generate bioactive IL-1β and implicate them as additional targets for the treatment of pathological IL-1-driven inflammatory responses
Higgs boson decays and production in the left–right twin Higgs model

AbstractThe left–right twin Higgs model predicts one neutral Higgs boson ϕ0 and it acquires mass mϕ0∼μr with the μ term, which can be lighter than half the SM-like Higgs boson mass in a portion of parameter space. Thus, the SM-like Higgs boson h can dominantly decay into a pair of light neutral Higgs bosons especially when mh is below the WW threshold. First, we examine the branching ratios of the SM-like Higgs boson decays and find that the new decay mode h→ϕ0ϕ0 is dominant for the case of mh>2mϕ0. Then we study the production via gluon fusion followed by the decay into two photons or two weak gauge bosons and found that the production rate can be significantly suppressed for some part of parameter space. Finally, we comparatively study the process γγ→h→bb¯ at ILC in the cases of mh>2mϕ0 and mh<2mϕ0, respectively. We find that these predictions can significantly deviated from the SM predictions, e.g., the gluon–gluon fusion channel, in the cases of mh>2mϕ0 and mh<2mϕ0, can be suppressed by about 80% and 45%, respectively. Therefor, it is possible to probe the left–right twin Higgs model via these Higgs boson production processes at the LHC experiment or in the future ILC experiment