pinecone/core-2020-05-10-deduplication huggingface dataset:
Efeito do NaCl a 0,9% e do NaCl a 0,45% sobre o sódio, cloreto e equilíbrio ácido-base em uma população de UTIP

OBJECTIVES:To study the effect of two intravenous maintenance fluids on plasma sodium (Na), and acid-base balance in pediatric intensive care patients during the first 24h of hospitalization.
METHODS:
A prospective randomized controlled study was performed, which allocated 233 patients to groups: (A) NaCl 0.9% or (B) NaCl 0.45%. Patients were aged 1 day to 18 years, had normal electrolyte concentrations, and suffered an acute insult (medical/surgical).
MAIN OUTCOME MEASURED:
change in plasma sodium. Parametric tests: t-tests, ANOVA, X2 statistical significance level was set at α=0.05.
RESULTS:
Group A (n=130): serum Na increased by 2.91 (±3.9)mmol/L at 24h (p<0.01); 2% patients had Na higher than 150mmol/L. Mean urinary Na: 106.6 (±56.8)mmol/L. No change in pH at 0 and 24h. Group B (n=103): serum Na did not display statistically significant changes. Fifteen percent of the patients had Na<135mmol/L at 24h. The two fluids had different effects on respiratory and post-operative situations.
CONCLUSIONS:
The use of saline 0.9% was associated with a lower incidence of electrolyte disturbances
Dynamic programming for deterministic discrete-time systems with uncertain gain.

We generalise the optimisation technique of dynamic programming for discrete-time systems with an uncertain gain function. We assume that uncertainty about the gain function is described by an imprecise probability model, which generalises the well-known Bayesian, or precise, models. We compare various optimality criteria that can be associated with such a model, and which coincide in the precise case: maximality, robust optimality and maximinity. We show that (only) for the first two an optimal feedback can be constructed by solving a Bellman-like equation
Dynamical masses of the low-mass stellar binary AB Doradus B

Context. ABDoradus is the main system of the ABDoradus moving group. It is a quadruple system formed by two widely separated binaries of pre-main-sequence (PMS) stars: ABDorA/C and ABDor Ba/Bb. The pair ABDorA/C has been extensively studied and its dynamical masses have been determined with high precision, thus making of ABDorC a benchmark for calibrating PMS stellar models. If the orbit and dynamical masses of the pair ABDor Ba/Bb can be determined, they could not only play a similar role to that of ABDorC in calibrating PMS models, but would also help to better understand the dynamics of the whole ABDoradus system. Aims. We aim to determine the individual masses of the pair ABDor Ba/Bb using VLBI observations and archive infrared data, as part of a larger program directed to monitor binary systems in the ABDoradus moving group. Methods. We observed the system ABDor B between 2007 and 2013 with the Australian Long Baseline Array (LBA), at a frequency of 8.4 GHz in phase-reference mode. Results. We detected, for the first time, compact radio emission from both stars in the binary, ABDor Ba and ABDor Bb. This result allowed us to determine the orbital parameters of both the relative and absolute orbits and, consequently, their individual dynamical masses: 0.28±0.05M_sun and 0.25±0.05M_sun, respectively. Conclusions. Comparisons of the dynamical masses with the prediction of PMS evolutionary models show that the models underpredict the dynamical masses of the binary components Ba and Bb by ~30 and 40%, respectively, although they all still agree at the 2-sigma level. The same stellar models favour an age between 50 and 100 Myr for this system. We also discuss the evolutionary status of ABDor Ba/Bb in terms of an earlier double-double star scenario that might explain the strong radio emission detected in both components
Superstring limit of Yang-Mills theories

It was pointed out by Shifman and Yung that the critical superstring on
$X^{10}={\mathbb R}^4\times Y^6$, where $Y^6$ is the resolved conifold, appears
as an effective theory for a U(2) Yang-Mills-Higgs system with four fundamental
Higgs scalars defined on $\Sigma_2\times{\mathbb R}^2$, where $\Sigma_2$ is a
two-dimensional Lorentzian manifold. Their Yang-Mills model supports semilocal
vortices on ${\mathbb R}^2\subset\Sigma_2\times{\mathbb R}^2$ with a moduli
space $X^{10}$. When the moduli of slowly moving thin vortices depend on the
coordinates of $\Sigma_2$, the vortex strings can be identified with critical
fundamental strings. We show that similar results can be obtained for the
low-energy limit of pure Yang-Mills theory on $\Sigma_2\times T^2_p$, where
$T^2_p$ is a two-dimensional torus with a puncture $p$. The solitonic vortices
of Shifman and Yung then get replaced by flat connections. Various
ten-dimensional superstring target spaces can be obtained as moduli spaces of
flat connections on $T^2_p$, depending on the choice of the gauge group. The
full Green-Schwarz sigma model requires extending the gauge group to a
supergroup and augmenting the action with a topological term.Comment: 1+11 pages, v2: minor correction
NNLL resummation for the associated production of a top pair and a Higgs
  boson at the LHC

We study the resummation of soft gluon emission corrections to the production
of a top-antitop pair in association with a Higgs boson at the Large Hadron
Collider. Starting from a soft-gluon resummation formula derived in previous
work, we develop a bespoke parton-level Monte Carlo program which can be used
to calculate the total cross section along with differential distributions. We
use this tool to study the phenomenological impact of the resummation to
next-to-next-to-leading logarithmic (NNLL) accuracy, finding that these
corrections increase the total cross section and the differential distributions
with respect to NLO calculations of the same observables.Comment: 26 pages, 9 figures. A few typos and an incorrect reference were
  fixe
Search for single production of vector-like quarks decaying into a b
  quark and a W boson in proton-proton collisions at sqrt(s) = 13 TeV

A search is presented for a heavy vector-like quark, decaying into a b quark
and a W boson, which is produced singly in association with a light flavor
quark and a b quark. The analysis is performed using a data sample of
proton-proton collisions at a center-of-mass energy of sqrt(s) = 13 TeV
collected at the LHC in 2015. The data set used in the analysis corresponds to
an integrated luminosity of 2.3 inverse femtobarns. The search is carried out
using events containing one electron or muon, at least one b-tagged jet with
large transverse momentum, at least one jet in the forward region of the
detector, and missing transverse momentum. No excess over the standard model
prediction is observed. Upper limits are placed on the production cross section
of heavy exotic quarks: a T quark with a charge of 2/3, and a Y quark with a
charge of -4/3. For Y quarks with coupling of 0.5 and B(Y to bW) = 100%, the
observed (expected) lower mass limits are 1.40 (1.0) TeV. This is the most
stringent limit to date on the single production of the Y vector-like quark.Comment: Replaced with the published version. Added the journal reference and
  DOI. All the figures and tables can be found at
  http://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-16-00
I see what you say: Prior knowledge of other's goals automatically biases the perception of their actions.

We investigated whether top-down expectations about an actor's intentions affect action perception in a representational momentum (RM) paradigm. Participants heard an actor declare an intention to either take or leave an object and then saw him either reach for or withdraw from it, such that action and intention were either congruent or incongruent. Observers generally misperceived the hand's disappearance point further along the trajectory than it actually was, in line with the idea that action perception incorporates predictions of the action's future course. Importantly, this RM effect was larger for actions congruent with the actor's goals than for incongruent actions. These results demonstrate that action prediction integrates both current motion and top-down knowledge about the actor's intention. They support recent theories that emphasise the role of prior expectancies and prediction errors in social (and non-social) cognitive processing
Governance traps in climate change politics : re-framing the debate in terms of responsibilities and rights.

There is a strong sense of malaise surrounding climate politics today. This has been created at least in part by factors such as the chasm between the scale of action required and the adequacy of current political commitments, stalemate in global negotiations, the low price of carbon, and a growing sense of indifference among the publics of some developed countries about the threat posed by climate change. Within the policy community these issues are generally treated as different problems each to be overcome on their own terms. Yet, we argue, suggested solutions to these problems hold much in common—namely a focus on identifying agency, whether the capacity of institutions to act or the behavior of individuals. What is often missing from such accounts of climate politics is a recognition that the problems of how agency is attributed, what we might term governance traps, are structural in nature. Governing climate change therefore requires that we study the conditions through which these challenges arise and which in turn serve to frame agency in particular ways. We suggest that examining the ways in which notions of responsibilities and rights are currently being framed within climate politics provides one way into these dynamics. This opens up the critical questions that need to be addressed ahead of the critical Conference of the Parties meeting in Paris in November 2015
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.

Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans. In human cells, Nek2 associates with centrosomes, and overexpression of active Nek2 has drastic consequences for centrosome structure. Here, we describe the molecular characterization of a novel human centrosomal protein, C-Nap1 (for centrosomal Nek2-associated protein 1), first identified as a Nek2-interacting protein in a yeast two-hybrid screen. Antibodies raised against recombinant C-Nap1 produced strong labeling of centrosomes by immunofluorescence, and immunoelectron microscopy revealed that C-Nap1 is associated specifically with the proximal ends of both mother and daughter centrioles. On Western blots, anti-C-Nap1 antibodies recognized a large protein (>250 kD) that was highly enriched in centrosome preparations. Sequencing of overlapping cDNAs showed that C-Nap1 has a calculated molecular mass of 281 kD and comprises extended domains of predicted coiled-coil structure. Whereas C-Nap1 was concentrated at centrosomes in all interphase cells, immunoreactivity at mitotic spindle poles was strongly diminished. Finally, the COOH-terminal domain of C-Nap1 could readily be phosphorylated by Nek2 in vitro, as well as after coexpression of the two proteins in vivo. Based on these findings, we propose a model implicating both Nek2 and C-Nap1 in the regulation of centriole-centriole cohesion during the cell cycle.This work was supported by the Swiss National Science Foundation (31-50576.97), the Swiss Cancer Leagure (267-1-1996), and the Canton of Geneva.Peer-reviewedPublisher Versio
Effect of intermittent pneumatic compression on disability, living circumstances, quality of life, and hospital costs after stroke : secondary analyses from CLOTS 3, a randomised trial

The study was jointly sponsored by the University of Edinburgh and NHS Lothian. The start-up phase of the trial (December, 2008, to March, 2010) was funded by the Chief Scientist Office of the Scottish Government (reference CZH/4/417). The main phase of the trial was funded by the NIHR HTA Programme (reference 08/14/03). Covidien lent its Kendall Express Sequential Compression System Controllers to our 105 centres and donated supplies of their sleeves. It also provided logistical help in keeping our centres supplied with sleeves and training materials relevant to the use of their devices. Recruitment and follow-up was supported by the NIHR funded UK Stroke research network and the Scottish Stroke Research network, which was supported by NHS Research Scotland. A full description of the trial will be published in the HTA journal series. The views and opinions expressed in this report are those of the authors and do not necessarily reflect those of the UK Department of Health or the Chief Scientist Office of the Scottish Government. Open Access funded by Department of Health UKPeer reviewedPublisher PD
Development of a candidate reference material for adventitious virus detection in vaccine and biologicals manufacturing by deep sequencing.

Unbiased deep sequencing offers the potential for improved adventitious virus screening in vaccines and biotherapeutics. Successful implementation of such assays will require appropriate control materials to confirm assay performance and sensitivity.
A common reference material containing 25 target viruses was produced and 16 laboratories were invited to process it using their preferred adventitious virus detection assay.
Fifteen laboratories returned results, obtained using a wide range of wet-lab and informatics methods. Six of 25 target viruses were detected by all laboratories, with the remaining viruses detected by 4-14 laboratories. Six non-target viruses were detected by three or more laboratories.
The study demonstrated that a wide range of methods are currently used for adventitious virus detection screening in biological products by deep sequencing and that they can yield significantly different results. This underscores the need for common reference materials to ensure satisfactory assay performance and enable comparisons between laboratories
The immune adaptor SLP-76 binds to SUMO-RANGAP1 at nuclear pore complex filaments to regulate nuclear import of transcription factors in T-cells

While immune cell adaptors regulate proximal T-cell signaling, direct regulation of the nuclear pore complex (NPC) has not been reported. NPC has cytoplasmic filaments composed of RanGAP1 and RanBP2 with the potential to interact with cytoplasmic mediators. Here, we show that the immune cell adaptor SLP-76 binds directly to SUMORanGAP1 of cytoplasmic fibrils of the NPC, and that this interaction is needed for optimal NFATc1 and NF-κB p65 nuclear entry in T-cells. Transmission electron microscopy showed anti-SLP-76 cytoplasmic labeling of the majority of NPCs in anti- CD3 activated T-cells. Further, SUMO-RanGAP1 bound to the N-terminal lysine-56 of SLP-76 where the interaction was needed for optimal RanGAP1-NPC localization and GAP exchange activity. While the SLP-76-RanGAP1 (K56E) mutant had no effect on proximal signaling, it impaired NF-ATc1 and p65/RelA nuclear entry and in vivo responses to OVA peptide. Overall, we have identified SLP-76 as a direct regulator of nuclear pore function in T-cells.The work was supported by the program grant from Wellcome Trust 092627/Z/10/Z (CER).This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.molcel.2015.07.01
Introducing global peat-specific temperature and pH calibrations based on brGDGT bacterial lipids.

Glycerol dialkyl glycerol tetraethers (GDGTs) are membrane-spanning lipids from Bacteria and Archaea that are ubiquitous in a range of natural archives and especially abundant in peat. Previous work demonstrated that the distribution of bacterial branched GDGTs (brGDGTs) in mineral soils is correlated to environmental factors such as mean annual air temperature (MAAT) and soil pH. However, the influence of these parameters on brGDGT distributions in peat is largely unknown. Here we investigate the distribution of brGDGTs in 470 samples from 96 peatlands around the world with a broad mean annual air temperature (−8 to 27 °C) and pH (3–8) range and present the first peat-specific brGDGT-based temperature and pH calibrations. Our results demonstrate that the degree of cyclisation of brGDGTs in peat is positively correlated with pH, pH = 2.49 x CBTpeat + 8.07 (n = 51, R2 = 0.58, RMSE = 0.8) and the degree of methylation of brGDGTs is positively correlated with MAAT, MAATpeat (°C) = 52.18 x MBT5me’ – 23.05 (n = 96, R2 = 0.76, RMSE = 4.7 °C). These peat-specific calibrations are distinct from the available mineral soil calibrations. In light of the error in the temperature calibration (∼ 4.7 °C), we urge caution in any application to reconstruct late Holocene climate variability, where the climatic signals are relatively small, and the duration of excursions could be brief. Instead, these proxies are well-suited to reconstruct large amplitude, longer-term shifts in climate such as deglacial transitions. Indeed, when applied to a peat deposit spanning the late glacial period (∼15.2 kyr), we demonstrate that MAATpeat yields absolute temperatures and relative temperature changes that are consistent with those from other proxies. In addition, the application of MAATpeat to fossil peat (i.e. lignites) has the potential to reconstruct terrestrial climate during the Cenozoic. We conclude that there is clear potential to use brGDGTs in peats and lignites to reconstruct past terrestrial climate
E(6) inspired SUSY benchmarks, dark matter relic density anda125 GeV Higgs

We explore the relic density of dark matter and the particle spectrum within a constrained version of an E₆ inspired SUSY model with an extra U(1)N gauge symmetry. In this model a single exact custodial symmetry forbids tree-level flavor-changing transitions and the most dangerous baryon and lepton number violating operators. We present a set of benchmark points showing scenarios that have a SM-like Higgs mass of 125 GeV and sparticle masses above the LHC limits. They lead to striking new physics signatures which may be observed during run II of the LHC and can distinguish this model from the simplest SUSY extensions of the SM. At the same time these benchmark scenarios are consistent with the measured dark matter abundance and necessarily lead to large dark matter direct detection cross sections close to current limits and observable soon at the XENON1T experiment.Peter Athron, Dylan Harries, Roman Nevzorov, Anthony G.William
Combustion syntheses of Co3O4 powders using different fuels

Co3O4 powders are used as pigment in solar selective paints. In this work, two new gel-combustion processes for the synthesis of  Co3O4 nanopowders with lysine (Lys) or ethylenediaminetetraacetic acid (Edta) as fuel are presented. The first route is a  conventional, stoichiometric process, while the second one is a non-stoichiometric, pH-controlled process. The samples were  calcined in air at 500 ºC. They were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM),  transmission electron microscopy (TEM), Fourier transform infrared spectrum (FTIR), Thermogravimetric analysis (TGA) and  differential scanning calorimetry (DSC) and the optical properties of the pigments were assessed with a spectrophotometer. In all  cases, powders exhibited the Co3O4 crystalline structure. A minimum crystallite average size of 19 nm for powders obtained by  the ?stoichiometric/Lys? combustion route was observed, meanwhile, a maximum value of 47 nm was stated for powders  obtained by the ?non-stoichiometric/Edta? combustion process. The average particle size ranged between 50 and 100 nm. The  powders obtained by the stoichiometric nitrate?lysine route were selected to study its optical properties, their solar absorption  was 88%, compared with the references, evidencing their aptitude to be used in solar absorbent paints.Fil: Gardey Merino, Maria Celeste. Universidad Tecnologica Nacional. Facultad Reg.mendoza. Grupo Cliope Energia, Ambiente y Desarrollo Sustentable; ArgentinaFil: Tornello Nasisi, Leonardo D.. Universidad Tecnologica Nacional. Facultad Reg.mendoza. Grupo Cliope Energia, Ambiente y Desarrollo Sustentable; ArgentinaFil: Montoya, William M. . Universidad Tecnologica Nacional. Facultad Reg.mendoza. Grupo Cliope Energia, Ambiente y Desarrollo Sustentable; ArgentinaFil: Urrutia Aguilera, Jesus N. . Universidad Tecnologica Nacional. Facultad Reg.mendoza. Grupo Cliope Energia, Ambiente y Desarrollo Sustentable; ArgentinaFil: Fernandez, Maria Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas de las Fuerzas Armadas. Centro de Investigaciones en Sólidos; ArgentinaFil: Lascalea, Gustavo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas; ArgentinaFil: Vazquez, Patricia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentin
Preparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpiride

A novel molecular imprinting polymer (MIP) was prepared by bulk polymerization using sulpiride as the template molecule, itaconic acid (ITA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker. The formation of the MIP was determined as the molar ratio of sulpiride-ITA-EGDMA of 1:4:15 by single-factor experiments. The MIP showed good adsorption property with imprinting factor α of 5.36 and maximum adsorption capacity of 61.13 μmol/g, and was characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and surface area analysis. With the structural analogs (amisulpride, tiapride, lidocaine and cisapride) and small molecules containing a mono-functional group (p-toluenesulfonamide, formamide and 1-methylpyrrolidine) as substrates, static adsorption, kinetic adsorption, and rebinding experiments were also performed to investigate the selective adsorption ability, kinetic characteristic, and recognition mechanism of the MIP. A serial study suggested that the highly selective recognition ability of the MIP mainly depended on binding sites provided by N-functional groups of amide and amine. Moreover, the MIP as solid-phase extractant was successfully applied to extraction of sulpiride from the mixed solution (consisted of p-toluenesulfonamide, sulfamethoxazole, sulfanilamide, p-nitroaniline, acetanilide and trimethoprim) and serum sample, and extraction recoveries ranged from 81.57% to 86.63%. The tentative tests of drug release in stimulated intestinal fluid (pH 6.8) demonstrated that the tablet with the MIP–sulpiride could obviously inhibit sulpiride release rate. Thus, ITA-based MIP is an efficient and promising alternative to solid-phase adsorbent for extraction of sulpiride and removal of interferences in biosample analysis, and could be used as a potential carrier for controlled drug releas