pinecone/core-2020-05-10-deduplication huggingface dataset:
Hadron-hadron interactions from N f = 2 + 1 + 1 lattice QCD: isospin-2 ππ scattering length

We present results for the I = 2 ππ scattering length using N f = 2 + 1 + 1 twisted mass lattice QCD for three values of the lattice spacing and a range of pion mass values. Due to the use of Laplacian Heaviside smearing our statistical errors are reduced compared to previous lattice studies. A detailed investigation of systematic effects such as discretisation effects, volume effects, and pollution of excited and thermal states is performed. After extrapolation to the physical point using chiral perturbation theory at NLO we obtain M π a 0  = − 0.0442(2) stat ( − 0 + 4 ) sys
Enhanced thj signal at the LHC with h→γγ decay and CP -violating top–Higgs coupling

We study the observability of non-standard top Yukawa couplings in the pp→t(→ℓνℓb)h(→γγ)j channel at 14 TeV high-luminosity LHC (HL-LHC). The small diphoton branching ratio is enhanced when the CP -violating phase, ξ , of the top–Higgs interaction is non-zero. When the modulus of the top–Higgs interaction assumes the SM value, yt=ytSM , we find that the signal significance reaches 2.7 σ (7.7σ) when ξ=0.25π (0.5π) . Furthermore, the different couplings modify the polarisation of the top quark, and can subsequently be distinguished via asymmetries in spin correlations with the final state leptons. The diphoton decay mode is found to be significantly more promising than the previously considered pp→t(→ℓνℓb)h(→bb¯)j channel
Quadratic α′ -corrections to heterotic double field theory

We investigate α′ -corrections of heterotic double field theory up to quadratic order in the language of supersymmetric O(D,D+dim⁡G) gauged double field theory. After introducing double-vielbein formalism with a parametrization which reproduces heterotic supergravity, we show that supersymmetry for heterotic double field theory up to leading order α′ -correction is obtained from supersymmetric gauged double field theory. We discuss the necessary modifications of the symmetries defined in supersymmetric gauged double field theory. Further, we construct supersymmetric completion at quadratic order in α′
Towards a first estimate of the gluon Sivers function from $A_N$ data in
  $pp$ collisions at RHIC

Within a generalized parton model approach, with inclusion of spin and
intrinsic transverse momentum effects, we show how the latest, highly precise,
midrapidity data on the transverse single spin asymmetry measured in
$pp\to\pi^0\, X$ by the PHENIX Collaboration at RHIC [1], can be used to get a
first estimate on the still poorly known gluon Sivers distribution. To this end
we also adopt the present information on the quark Sivers functions, as
extracted from semi-inclusive deeply inelastic scattering data. This analysis
updates a previous study by some of us where a first bound on this distribution
was obtained [2]
Follow-up observations of X-ray emitting hot subdwarf star: the He-rich
  sdO BD +37° 1977

We report on the results of the first XMM-Newton satellite observation of the
luminous and helium-rich O-type subdwarf BD +37{\deg} 1977 carried out in April
2014. X-ray emission is detected with a flux of about 4*10^(-14) erg/cm2/s
(0.2-1.5 keV), corresponding to a f_X/f_bol ratio about 10^(-7); the source
spectrum is very soft, and is well fit by the sum of two plasma components at
different temperatures. Both characteristics are in agreement with what is
observed in the main-sequence early-type stars, where the observed X-ray
emission is due to turbulence and shocks in the stellar wind. A smaller but
still significant stellar wind has been observed also in BD +37{\deg} 1977;
therefore, we suggest that also in this case the detected X-ray flux has the
same origin
Electronic stress tensor analysis of molecules in gas phase of CVD process for GeSbTe alloy.

Article first published online: 23 APR 2015We analyze the electronic structure of molecules which may exist in gas phase of chemical vapor deposition process for GeSbTe alloy using the electronic stress tensor, with special focus on the chemical bonds between Ge, Sb, and Te atoms. We find that, from the viewpoint of the electronic stress tensor, they have intermediate properties between alkali metals and hydrocarbon molecules. We also study the correlation between the bond order which is defined based on the electronic stress tensor, and energy-related quantities. We find that the correlation with the bond dissociation energy is not so strong while one with the force constant is very strong. We interpret these results in terms of the energy density on the "Lagrange surface, " which is considered to define the boundary surface of atoms in a molecule in the framework of the electronic stress tensor analysis
OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition.

ヒト角膜上皮分化を規定している新分子を発見－OVOL2は角膜上皮における上皮性恒常維持に関与－. 京都大学プレスリリース. 2016-05-09.In development, embryonic ectoderm differentiates into neuroectoderm and surface ectoderm using poorly understood mechanisms. Here, we show that the transcription factor OVOL2 maintains the transcriptional program of human corneal epithelium cells (CECs), a derivative of the surface ectoderm, and that OVOL2 may regulate the differential transcriptional programs of the two lineages. A functional screen identified OVOL2 as a repressor of mesenchymal genes to maintain CECs. Transduction of OVOL2 with several other transcription factors induced the transcriptional program of CECs in fibroblasts. Moreover, neuroectoderm derivatives were found to express mesenchymal genes, and OVOL2 alone could induce the transcriptional program of CECs in neural progenitors by repressing these genes while activating epithelial genes. Our data suggest that the difference between the transcriptional programs of some neuroectoderm- and surface ectoderm-derivative cells may be regulated in part by a reciprocally repressive mechanism between epithelial and mesenchymal genes, as seen in epithelial-to-mesenchymal transition
Analytic combinatorics of chord and hyperchord diagrams with k crossings

Using methods from Analytic Combinatorics, we study the families of perfect matchings, partitions, chord diagrams, and hyperchord diagrams on a disk with a prescribed number of crossings. For each family, we express the generating function of the configurations with exactly k crossings as a rational function of the generating function of crossing-free configurations. Using these expressions, we study the singular behavior of these generating functions and derive asymptotic results on the counting sequences of the configurations with precisely k crossings. Limiting distributions and random generators are also studied.Postprint (author's final draft
Coherence imaging of scrape-off-layer and divertor impurity flows in the Mega Amp Spherical Tokamak (invited).

A new coherence imaging Doppler spectroscopy diagnostic has been deployed on the UK’s Mega Amp Spherical Tokamak for scrape-off-layer and divertor impurity flow measurements. The system has successfully obtained 2D images of C III, C II, and He II line-of-sight flows, in both the lower divertor and main scrape-off-layer. Flow imaging has been obtained at frame rates up to 1 kHz, with flow resolution of around 1 km/s and spatial resolution better than 1 cm, over a 40° field of view. C III data have been tomographically inverted to obtain poloidal profiles of the parallel impurity flow in the divertor under various conditions. In this paper we present the details of the instrument design, operation, calibration, and data analysis as well as a selection of flow imaging results which demonstrate the diagnostic's capabilities
Search for heavy long-lived charged $R$-hadrons with the ATLAS detector
  in 3.2 fb$^{-1}$ of proton--proton collision data at $\sqrt{s} = 13$ TeV

A search for heavy long-lived charged $R$-hadrons is reported using a data
sample corresponding to 3.2$^{-1}$ of proton--proton collisions at $\sqrt{s} =
13$ TeV collected by the ATLAS experiment at the Large Hadron Collider at CERN.
The search is based on observables related to large ionisation losses and slow
propagation velocities, which are signatures of heavy charged particles
travelling significantly slower than the speed of light. No significant
deviations from the expected background are observed. Upper limits at 95%
confidence level are provided on the production cross section of long-lived
$R$-hadrons in the mass range from 600 GeV to 2000 GeV and gluino, bottom and
top squark masses are excluded up to 1580 GeV, 805 GeV and 890 GeV,
respectively.Comment: 15 pages, plus author list: 32 pages total, 5 figures, 3 tables.
  Submitted to PLB. All figures including auxiliary figures are available at
  http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/SUSY-2016-02
Effects of the d-donor level of vanadium on the properties of Zn1-xVxO films

We report the effect of d-levels of vanadium atoms on the electronic band structure of ZnO. Polycrystalline layers of Zn 1−xVxO with 0 ≤ x ≤ 0.08 were synthesized using magnetron sputtering technique. Electrical measurements show that electron concentration increases with vanadium up to x == 0.04 and then decreases and films become insulating for x > 0.06. Optical characterization reveals that the absorption edge shifts to higher energy, while the photoluminescence (PL) peak shows a shift to lower energy with increasing vanadium content. This unusual optical behavior can be explained by an anticrossing interaction between the vanadium d-levels and the conduction band (CB) of ZnO. The interaction results in an upward shift of unoccupied CB ( E+E+ ) and the downward shift of the fully occupied E−E− band derived from the vanadium d-levels. The composition dependence of optical absorption edge ( E+E+ ) and PL peak ( E−E− ) can be fitted using the Band Anticrossing model with the vanadium d-level located at 0.13 eV below CB of ZnO and a coupling constant of 0.65 eV
Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency

N-terminal acetylation is a common protein modification in eukaryotes associated with numerous cellular processes. Inherited mutations in NAA10, encoding the catalytic subunit of the major N-terminal acetylation complex NatA have been associated with diverse, syndromic X-linked recessive disorders, whereas de novo missense mutations have been reported in one male and one female individual with severe intellectual disability but otherwise unspecific phenotypes. Thus, the full genetic and clinical spectrum of NAA10 deficiency is yet to be delineated. We identified three different novel and one known missense mutation in NAA10, de novo in 11 females, and due to maternal germ line mosaicism in another girl and her more severely affected and deceased brother. In vitro enzymatic assays for the novel, recurrent mutations p.(Arg83Cys) and p.(Phe128Leu) revealed reduced catalytic activity. X-inactivation was random in five females. The core phenotype of X-linked NAA10-related N-terminal-acetyltransferase deficiency in both males and females includes developmental delay, severe intellectual disability, postnatal growth failure with severe microcephaly, and skeletal or cardiac anomalies. Genotype-phenotype correlations within and between both genders are complex and may include various factors such as location and nature of mutations, enzymatic stability and activity, and X-inactivation in females
Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration.

Contains fulltext :
                  156882.pdf (publisher's version ) (Open Access)RATIONALE: A number of randomized trials are underway, which will address the effects of angiotensin receptor blockers (ARBs) on aortic root enlargement and a range of other end points in patients with Marfan syndrome. If individual participant data from these trials were to be combined, a meta-analysis of the resulting data, totaling approximately 2,300 patients, would allow estimation across a number of trials of the treatment effects both of ARB therapy and of beta-blockade. Such an analysis would also allow estimation of treatment effects in particular subgroups of patients on a range of end points of interest and would allow a more powerful estimate of the effects of these treatments on a composite end point of several clinical outcomes than would be available from any individual trial. DESIGN: A prospective, collaborative meta-analysis based on individual patient data from all randomized trials in Marfan syndrome of (i) ARBs versus placebo (or open-label control) and (ii) ARBs versus beta-blockers will be performed. A prospective study design, in which the principal hypotheses, trial eligibility criteria, analyses, and methods are specified in advance of the unblinding of the component trials, will help to limit bias owing to data-dependent emphasis on the results of particular trials. The use of individual patient data will allow for analysis of the effects of ARBs in particular patient subgroups and for time-to-event analysis for clinical outcomes. The meta-analysis protocol summarized in this report was written on behalf of the Marfan Treatment Trialists' Collaboration and finalized in late 2012, without foreknowledge of the results of any component trial, and will be made available online (http://www.ctsu.ox.ac.uk/research/meta-trials).1 mei 201
Analysis of the $\pi^+ \pi^- \pi^+ \pi-$ and $\pi^+ \pi^{0}\pi^- \pi^{0}$ final states in quasi-real two-photon collisions at LEP

The reactions gamma gamma -> pi^+pi^-pi^+pi^- and gamma gamma -> pi^+pi^0pi^-pi^0 are studied with the L3 detector at LEP in a data sample collected at centre-of-mass energies from 161GeV to 209GeV with a total integrated luminosity of 698/pb. A spin-parity-helicity analysis of the rho^0 rho^0 and rho^+ rho^- systems for two-photon centre-of-mass energies between 1GeV and 3GeV shows the dominance of the spin-parity state 2+ with helicity 2. The contribution of 0+ and 0- spin-parity states is also observed, whereas contributions of 2- states and of a state with spin-parity 2+ and zero helicity are found to be negligible.The reactions gamma gamma -> pi^+pi^-pi^+pi^- and gamma gamma -> pi^+pi^0pi^-pi^0 are studied with the L3 detector at LEP in a data sample collected at centre-of-mass energies from 161GeV to 209GeV with a total integrated luminosity of 698/pb. A spin-parity-helicity analysis of the rho^0 rho^0 and rho^+ rho^- systems for two-photon centre-of-mass energies between 1GeV and 3GeV shows the dominance of the spin-parity state 2+ with helicity 2. The contribution of 0+ and 0- spin-parity states is also observed, whereas contributions of 2- states and of a state with spin-parity 2+ and zero helicity are found to be negligible.The reactions γγ→π+π−π+π− and γγ→π+π0π−π0 are studied with the L3 detector at LEP in a data sample collected at centre-of-mass energies from 161 GeV to 209 GeV with a total integrated luminosity of 698 pb −1 . A spin-parity-helicity analysis of the ρ0ρ0 and ρ+ρ− systems for two-photon centre-of-mass energies between 1 and 3 GeV shows the dominance of the spin-parity state 2+ with helicity 2. The contribution of 0+ and 0− spin-parity states is also observed, whereas contributions of 2− states and of a state with spin-parity 2+ and zero helicity are found to be negligible
Locked into Copenhagen pledges - Implications of short-term emission targets for the cost and feasibility of long-term climate goals

This paper provides an overview of the AMPERE modeling comparison project with focus on the implications of near-term policies for the costs and attainability of long-term climate objectives. Nine modeling teams participated in the project to explore the consequences of global emissions following the proposed policy stringency of the national pledges from the Copenhagen Accord and Cancun Agreements to 2030. Specific features compared to earlier assessments are the explicit consideration of near-term 2030 emission targets as well as the systematic sensitivity analysis for the availability and potential of mitigation technologies. Our estimates show that a 2030 mitigation effort comparable to the pledges would result in a further "lock-in" of the energy system into fossil fuels and thus impede the required energy transformation to reach low greenhouse-gas stabilization levels (450 ppm CO2e). Major implications include significant increases in mitigation costs, increased risk that low stabilization targets become unattainable, and reduced chances of staying below the proposed temperature change target of 2 degrees C in case of overshoot. With respect to technologies, we find that following the pledge pathways to 2030 would narrow policy choices, and increases the risks that some currently optional technologies, such as carbon capture and storage (CCS) or the large-scale deployment of bioenergy, will become "a must" by 2030
Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1.

Mesenchymal stem cells (MSC) represent a promising therapeutic approach in many diseases in view of their potent immunomodulatory properties, which are only partially understood. Here, we show that the endothelium is a specific and key target of MSC during immunity and inflammation. In mice, MSC inhibit activation and proliferation of endothelial cells in remote inflamed lymph nodes (LNs), affect elongation and arborization of high endothelial venules (HEVs) and inhibit T-cell homing. The proteomic analysis of the MSC secretome identified the tissue inhibitor of metalloproteinase-1 (TIMP-1) as a potential effector molecule responsible for the anti-angiogenic properties of MSC. Both in vitro and in vivo, TIMP-1 activity is responsible for the anti-angiogenic effects of MSC, and increasing TIMP-1 concentrations delivered by an Adeno Associated Virus (AAV) vector recapitulates the effects of MSC transplantation on draining LNs. Thus, this study discovers a new and highly efficient general mechanism through which MSC tune down immunity and inflammation, identifies TIMP-1 as a novel biomarker of MSC-based therapy and opens the gate to new therapeutic approaches of inflammatory diseases
Preliminary results for RR Lyrae stars and Classical Cepheids from the
  Vista Magellanic Cloud (VMC) Survey

The Vista Magellanic Cloud (VMC, PI M.R. Cioni) survey is collecting
$K_S$-band time series photometry of the system formed by the two Magellanic
Clouds (MC) and the "bridge" that connects them. These data are used to build
$K_S$-band light curves of the MC RR Lyrae stars and Classical Cepheids and
determine absolute distances and the 3D geometry of the whole system using the
$K$-band period luminosity ($PLK_S$), the period - luminosity - color ($PLC$)
and the Wesenhiet relations applicable to these types of variables. As an
example of the survey potential we present results from the VMC observations of
two fields centered respectively on the South Ecliptic Pole and the 30 Doradus
star forming region of the Large Magellanic Cloud. The VMC $K_S$-band light
curves of the RR Lyrae stars in these two regions have very good photometric
quality with typical errors for the individual data points in the range of
$\sim$ 0.02 to 0.05 mag. The Cepheids have excellent light curves (typical
errors of $\sim$ 0.01 mag). The average $K_S$ magnitudes derived for both types
of variables were used to derive $PLK_S$ relations that are in general good
agreement within the errors with the literature data, and show a smaller
scatter than previous studies.Comment: 7 pages, 6 figure. Accepted for publication in Astrophysics and Space
  Science. Following a presentation at the conference "The Fundamental Cosmic
  Distance Scale: State of the Art and the Gaia Perspective", Naples, May 201
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

The genetic causes of malformations of cortical development (MCD) remain largely unknown. Here we report the discovery of multiple pathogenic missense mutations in TUBG1, DYNC1H1 and KIF2A, as well as a single germline mosaic mutation in KIF5C, in subjects with MCD. We found a frequent recurrence of mutations in DYNC1H1, implying that this gene is a major locus for unexplained MCD. We further show that the mutations in KIF5C, KIF2A and DYNC1H1 affect ATP hydrolysis, productive protein folding and microtubule binding, respectively. In addition, we show that suppression of mouse Tubg1 expression in vivo interferes with proper neuronal migration, whereas expression of altered gamma-tubulin proteins in Saccharomyces cerevisiae disrupts normal microtubule behavior. Our data reinforce the importance of centrosomal and microtubule-related proteins in cortical development and strongly suggest that microtubule-dependent mitotic and postmitotic processes are major contributors to the pathogenesis of MCD
Deglycosylation Step to Improve the Identification of Egg Proteins in Art Samples

A deglycosylation step using Peptide-N-Glycosidase F (PNGaseF) has been introduced in a standard proteomic protocol to more confidently identify egg based binders. The ingenuity of introducing a PNGaseF digestion was aimed at removing the molecular hindrance, made up by the heavily glycosylated egg proteins, before the protease(s) hydrolysis. This novelty in the protocol resulted in obtaining a significant increase of proteolytic egg peptides thus improving the quality and reliability of egg identification in artwork samples. The protocol has been set up on paint replicas and successfully tested on two historical samples of different origin
Low frequency dynamics of the nitrogenase MoFe protein via femtosecond pump probe spectroscopy - Observation of a candidate promoting vibration

We have used femtosecond pump-probe spectroscopy (FPPS) to study the FeMo-cofactor within the nitrogenase (N2ase) MoFe protein from Azotobacter vinelandii. A sub-20-fs visible laser pulse was used to pump the sample to an excited electronic state, and a second sub-10-fs pulse was used to probe changes in transmission as a function of probe wavelength and delay time. The excited protein relaxes to the ground state with a ~1.2ps time constant. With the short laser pulse we coherently excited the vibrational modes associated with the FeMo-cofactor active site, which are then observed in the time domain. Superimposed on the relaxation dynamics, we distinguished a variety of oscillation frequencies with the strongest band peaks at ~84, 116, 189, and 226cm(-1). Comparison with data from nuclear resonance vibrational spectroscopy (NRVS) shows that the latter pair of signals comes predominantly from the FeMo-cofactor. The frequencies obtained from the FPPS experiment were interpreted with normal mode calculations using both an empirical force field (EFF) and density functional theory (DFT). The FPPS data were also compared with the first reported resonance Raman (RR) spectrum of the N2ase MoFe protein. This approach allows us to outline and assign vibrational modes having relevance to the catalytic activity of N2ase. In particular, the 226cm(-1) band is assigned as a potential 'promoting vibration' in the H-atom transfer (or proton-coupled electron transfer) processes that are an essential feature of N2ase catalysis. The results demonstrate that high-quality room-temperature solution data can be obtained on the MoFe protein by the FPPS technique and that these data provide added insight to the motions and possible operation of this protein and its catalytic prosthetic group