pinecone/core-2020-05-10-deduplication huggingface dataset:
Intradermal grass pollen immunotherapy increases TH2 and IgE responses and worsens respiratory allergic symptoms

BackgroundRepeated low-dose grass pollen intradermal allergen injection suppresses allergen-induced cutaneous late-phase responses comparably with conventional subcutaneous and sublingual immunotherapy.ObjectiveWe sought to evaluate the efficacy and safety of grass pollen intradermal immunotherapy in the treatment of allergic rhinitis.MethodsWe randomly assigned 93 adults with grass pollen–induced allergic rhinitis to receive 7 preseasonal intradermal allergen injections (containing 7 ng of Phl p 5 major allergen) or a histamine control. The primary end point was daily combined symptom-medication scores during the 2013 pollen season (area under the curve). Analysis was by intention to treat. Skin biopsy specimens were collected after intradermal allergen challenges, and late-phase responses were measured 4 and 7, 10, or 13 months after treatment.ResultsThere was no significant difference in the primary end point between treatment arms (active, n = 46; control, n = 47; median difference, 14; 95% CI, −172.5 to 215.1; P = .80). Among secondary end points, nasal symptoms were worse in the intradermal treatment group, as measured based on daily (median difference, 35; 95% CI, 4.0-67.5; P = .03) and visual analog scale (median difference, 53; 95% CI, −11.6 to 125.2; P = .05) scores. In a per-protocol analysis intradermal immunotherapy was further associated with worse asthma symptoms and fewer symptom-free days. Intradermal immunotherapy increased serum Phleum pratense–specific IgE levels (P = .001) compared with those in the control arm. T cells cultured from biopsy specimens of subjects undergoing intradermal immunotherapy had higher expression of the TH2 surface marker CRTH2 (P = .04) and lower expression of the TH1 marker CXCR3 (P = .01), respectively. Late-phase responses remained inhibited 7 months after treatment (P = .03).ConclusionIntradermal allergen immunotherapy suppressed skin late-phase responses but was not clinically effective and resulted in worsening of respiratory allergic symptoms
Combined inoculation with Glomus intraradices and Rhizobium tropici CIAT899 increases phosphorus use efficiency for symbiotic nitrogen fixation in common bean (Phaseolus vulgaris L.)

AbstractThis study compared the response of common bean (Phaseolus vulgaris L.) to arbuscular mycorrhizal fungi (AMF) and rhizobia strain inoculation. Two common bean genotypes i.e. CocoT and Flamingo varying in their effectiveness for nitrogen fixation were inoculated with Glomus intraradices and Rhizobium tropici CIAT899, and grown for 50days in soil–sand substrate in glasshouse conditions. Inoculation of common bean plants with the AM fungi resulted in a significant increase in nodulation compared to plants without inoculation. The combined inoculation of AM fungi and rhizobia significantly increased various plant growth parameters compared to simple inoculated plants. In addition, the combined inoculation of AM fungi and rhizobia resulted in significantly higher nitrogen and phosphorus accumulation in the shoots of common bean plants and improved phosphorus use efficiency compared with their controls, which were not dually inoculated. It is concluded that inoculation with rhizobia and arbuscular mycorrhizal fungi could improve the efficiency in phosphorus use for symbiotic nitrogen fixation especially under phosphorus deficiency
Candidate Adaptor Protein CED-6 Promotes the Engulfment of Apoptotic Cells in C. elegans

AbstractThe rapid engulfment (phagocytosis) of cells undergoing programmed cell death (apoptosis) is a fundamental biological process that is not well understood. Here we report the cloning and functional characterization of ced-6, a gene specifically required for the engulfment of apoptotic cells in the nematode C. elegans. The CED-6 protein contains a phosphotyrosine binding domain at its N terminus and a proline/serine-rich region in its C-terminal half. Genetic mosaic analysis demonstrates that ced-6 acts within engulfing cells. We also show that ced-6 can promote the engulfment of cells at both early and late stages of apoptosis. Our data suggest that CED-6 is an adaptor molecule acting in a signal transduction pathway that specifically mediates the recognition and engulfment of apoptotic cells
Order one equations with the Painlevé property

AbstractDifferential equations with the Painleve property have been studied extensively due to their appearance in many branches of mathematics and their applicability in physics. Although a modern, differential algebraic treatment of the order one equations appeared before, the connection with the classical theory did not. Using techniques from algebraic geometry we provide the link between the classical and the modern treatment, and with the help of differential Galois theory a new classification is derived, both for characteristic 0 and p
Reducing Uncertainty in PHM by Accounting for Human Factors – A Case Study in the Biopharmaceutical Industry

AbstractThe ultimate goal of prognostics within Through-life Engineering Services (TES) is to accurately predict the remaining useful life (RUL) of components. Prognostic frameworks inherently presume that there is predictability in the failure rate of the system, i.e. a system experiencing exclusively stochastic failure events cannot, by definition, be predictable. Prediction model uncertainties must be bound in some logical way. Therefore, to achieve an accurate prognostic model, uncertainty must first be reduced through the identification and elimination of the root causes of random failure events. This research investigates human error in maintenance activities as a major cause of random failure events, using a case study from the biopharmaceutical industry. Elastomer failures remain the number one contamination risk in this industry and data shows unexplained variability in the lifetime of real components when compared to accelerated lifetime testing in the lab environment. Technician error during installation and maintenance activities of elastomers is one possible cause for this and this research explores how these errors can be eliminated, reduced, or accounted for within the reliability modeling process. The initial approach followed was to improve technician training in order to reduce errors and thereby reduce the variability of random failure events. Subsequent data has shown an improvement in key metrics with failures now more closely matching data from lab testing. However, there is scope for further improvements and future research will explore the role of performance influencing factors in the maintenance task to identify additional causes of variation. These factors may then be incorporated as a process variable in a prognostics and health management (PHM) model developed for the system. The paper will present these data fusion approaches accounting for human factors as a roadmap to improving PHM model reliability
Black hole formation and classicalization in ultra-Planckian 2→N scattering

AbstractWe establish a connection between the ultra-Planckian scattering amplitudes in field and string theory and unitarization by black hole formation in these scattering processes. Using as a guideline an explicit microscopic theory in which the black hole represents a bound-state of many soft gravitons at the quantum critical point, we were able to identify and compute a set of perturbative amplitudes relevant for black hole formation. These are the tree-level N-graviton scattering S-matrix elements in a kinematical regime (called classicalization limit) where the two incoming ultra-Planckian gravitons produce a large number N of soft gravitons. We compute these amplitudes by using the Kawai–Lewellen–Tye relations, as well as scattering equations and string theory techniques. We discover that this limit reveals the key features of the microscopic corpuscular black hole N-portrait. In particular, the perturbative suppression factor of a N-graviton final state, derived from the amplitude, matches the non-perturbative black hole entropy when N reaches the quantum criticality value, whereas final states with different value of N are either suppressed or excluded by non-perturbative corpuscular physics. Thus we identify the microscopic reason behind the black hole dominance over other final states including non-black hole classical object. In the parameterization of the classicalization limit the scattering equations can be solved exactly allowing us to obtain closed expressions for the high-energy limit of the open and closed superstring tree-level scattering amplitudes for a generic number N of external legs. We demonstrate matching and complementarity between the string theory and field theory in different large-s and large-N regimes
Supergravity background of λ-deformed model for AdS2×S2 supercoset

AbstractStarting with the Fˆ/G supercoset model corresponding to the AdSn×Sn superstring one can define the λ-model of arXiv:1409.1538 either as a deformation of the Fˆ/Fˆ gauged WZW model or as an integrable one-parameter generalisation of the non-abelian T-dual of the AdSn×Sn superstring sigma model with respect to the whole supergroup Fˆ. Here we consider the case of n=2 and find the explicit form of the 4d target space background for the λ-model for the PSU(1,1|2)/SO(1,1)×SO(2) supercoset. We show that this background represents a solution of type IIB 10d supergravity compactified on a 6-torus with only metric, dilaton Φ and the RR 5-form (represented by a 2-form F in 4d) being non-trivial. This implies that the λ-model is Weyl invariant at the quantum level and thus defines a consistent superstring sigma model. The supergravity solution we find is different from the one in arXiv:1410.1886 which should correspond to a version of the λ-model where only the bosonic subgroup of Fˆ is gauged. Still, the two solutions have equivalent scaling limit of arXiv:1504.07213 leading to the isometric background for the metric and eΦF which is related to the η-deformed AdS2×S2 sigma model of arXiv:1309.5850. Similar results are expected in the AdS3×S3 and AdS5×S5 cases
Individualized versus conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial

ObjectiveTo compare the efficacy and safety of follitropin delta, a new human recombinant FSH with individualized dosing based on serum antimüllerian hormone (AMH) and body weight, with conventional follitropin alfa dosing for ovarian stimulation in women undergoing IVF.DesignRandomized, multicenter, assessor-blinded, noninferiority trial (ESTHER-1).SettingReproductive medicine clinics.Patient(s)A total of 1,329 women (aged 18–40 years).Intervention(s)Follitropin delta (AMH <15 pmol/L: 12 μg/d; AMH ≥15 pmol/L: 0.10–0.19 μg/kg/d; maximum 12 μg/d), or follitropin alfa (150 IU/d for 5 days, potential subsequent dose adjustments; maximum 450 IU/d).Main Outcomes Measure(s)Ongoing pregnancy and ongoing implantation rates; noninferiority margins −8.0%.Result(s)Ongoing pregnancy (30.7% vs. 31.6%; difference −0.9% [95% confidence interval (CI) −5.9% to 4.1%]), ongoing implantation (35.2% vs. 35.8%; −0.6% [95% CI −6.1% to 4.8%]), and live birth (29.8% vs. 30.7%; −0.9% [95% CI −5.8% to 4.0%]) rates were similar for individualized follitropin delta and conventional follitropin alfa. Individualized follitropin delta resulted in more women with target response (8–14 oocytes) (43.3% vs. 38.4%), fewer poor responses (fewer than four oocytes in patients with AMH <15 pmol/L) (11.8% vs. 17.9%), fewer excessive responses (≥15 or ≥20 oocytes in patients with AMH ≥15 pmol/L) (27.9% vs. 35.1% and 10.1% vs. 15.6%, respectively), and fewer measures taken to prevent ovarian hyperstimulation syndrome (2.3% vs. 4.5%), despite similar oocyte yield (10.0 ± 5.6 vs. 10.4 ± 6.5) and similar blastocyst numbers (3.3 ± 2.8 vs. 3.5 ± 3.2), and less gonadotropin use (90.0 ± 25.3 vs. 103.7 ± 33.6 μg).Conclusion(s)Optimizing ovarian response in IVF by individualized dosing according to pretreatment patient characteristics results in similar efficacy and improved safety compared with conventional ovarian stimulation.Clinical Trial Registration NumberNCT01956110
Measurement of zero degree single photon energy spectra for s=7 TeV proton–proton collisions at LHC

AbstractIn early 2010, the Large Hadron Collider forward (LHCf) experiment measured very forward neutral particle spectra in LHC proton–proton collisions. From a limited data set taken under the best beam conditions (low beam-gas background and low occurrence of pile-up events), the single photon spectra at s=7 TeV and pseudo-rapidity (η) ranges from 8.81 to 8.99 and from 10.94 to infinity were obtained for the first time and are reported in this Letter. The spectra from two independent LHCf detectors are consistent with one another and serve as a cross check of the data. The photon spectra are also compared with the predictions of several hadron interaction models that are used extensively for modeling ultra-high energy cosmic-ray showers. Despite conservative estimates for the systematic errors, none of the models agree perfectly with the measurements. A notable difference is found between the data and the DPMJET 3.04 and PYTHIA 8.145 hadron interaction models above 2 TeV where the models predict higher photon yield than the data. The QGSJET II-03 model predicts overall lower photon yield than the data, especially above 2 TeV in the rapidity range 8.81<η<8.99
A4 and CP symmetry and a model with maximal CP violation

AbstractWe study a second CP symmetry compatible with the A4 flavor group, which interchanges the representations 1′ and 1″. We analyze the lepton mixing patterns arising from the A4 and CP symmetry broken to residual subgroups Z3 and Z2×CP in the charged lepton and neutrino sectors respectively. One phenomenologically viable mixing pattern is found, and it predicts maximal atmospheric mixing angle as well as maximal Dirac CP phase, trivial Majorana phases and the correlation sin2⁡θ12cos2⁡θ13=1/3. We construct a concrete model based on the A4 and CP symmetry, the above interesting mixing pattern is achieved, the observed charged lepton mass hierarchy is reproduced, and the reactor mixing angle θ13 is of the correct order
Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx Protein

SummarySAMHD1 has recently been identified as an HIV-1 restriction factor operating in myeloid cells. As a countermeasure, the Vpx accessory protein from HIV-2 and certain lineages of SIV have evolved to antagonize SAMHD1 by inducing its ubiquitin-proteasome-dependent degradation. Here, we show that SAMHD1 experienced strong positive selection episodes during primate evolution that occurred in the Catarrhini ancestral branch prior to the separation between hominoids (gibbons and great apes) and Old World monkeys. The identification of SAMHD1 residues under positive selection led to mapping the Vpx-interaction domain of SAMHD1 to its C-terminal region. Importantly, we found that while SAMHD1 restriction activity toward HIV-1 is evolutionarily maintained, antagonism of SAMHD1 by Vpx is species-specific. The distinct evolutionary signature of SAMHD1 sheds light on the development of its antiviral specificity
Deterministic regression model and visual basic code for optimal forecasting of financial time series

AbstractA new, non-statistical method is presented for analysis of the past history and current evolution of economic and financial processes. The method is based on the sliding model approach using linear differential or difference equations applied to discrete information in the form of known chronological data (time series) about the process. An algorithm is proposed that allows one to project the current evolution of the process onto some period of its future development. Computer code in visual basic is developed that has been validated in application to American stock index S&P 500, with predicted values within 5% of real data over long periods of the recent past history. The algorithm and the code can be applied to practical problems in finance and economy in time of its normal evolution without catastrophic events
One-neutron knockout reaction of 17C on a hydrogen target at 70 MeV/nucleon

AbstractFirst experimental evidence of the population of the first 2− state in 16C above the neutron threshold is obtained by neutron knockout from 17C on a hydrogen target. The invariant mass method combined with in-beam γ-ray detection is used to locate the state at 5.45(1) MeV. Comparison of its populating cross section and parallel momentum distribution with a Glauber model calculation utilizing the shell-model spectroscopic factor confirms the core-neutron removal nature of this state. Additionally, a previously known unbound state at 6.11 MeV and a new state at 6.28(2) MeV are observed. The position of the first 2− state, which belongs to a member of the lowest-lying p–sd cross shell transition, is reasonably well described by the shell-model calculation using the WBT interaction
The virtual photon–gluon impact factor with massive quarks and exact gluon kinematics

AbstractWe calculate the impact factor coupling a virtual photon to a gluon via a massive quark–antiquark pair at LL order, but with the imposition of the correct gluon kinematics. Exact analytical results are presented in triple Mellin space with respect to scaled Bjorken x, gluon transverse momentum and heavy quark mass. The application of these results to the calculation of approximate NLL coefficient functions needed to relate structure functions to the BFKL gluon is presented. The NLL effects with running coupling are seen to lead to a suppression of the small x divergence when compared with the fixed and running coupling LL results, but less than in the massless case
CO2 Sequestration by Natural Zeolite for Greenhouse Effect Control

AbstractThis paper describes the adsorption of CO2 on pores in natural erionite exchanged with aqueous solutions of Na+, Mg2+, and Ca2+ salts at different concentrations, variable time and temperature of treatment. Experimental data of CO2 adsorption were treated by the Freundlich and Langmuir equations. Complementarily were evaluated standard adsorption energies and the degree of interaction of the gas with the zeolite; the evolution of isosteric heats of adsorption was analyzed. The exchange with Na+ favors the creation of emergent pores thus causing an increase of the adsorption capacity for CO2. The presence of Na+ at micropore entrances causes an increased adsorption into the nanocavities and on the external area of the ion-exchanged zeolites. The development of nanopores in erionite was evaluated through the Barrett-Joyner-Halenda and NLDFT methods. Depending on the conditions of the exchange treatment, Na+ was found to be most favorable, well distributed, and accessible for N2 adsorption
Identification of the regions involved in phonological assembly using a novel paradigm

AbstractHere we adopt a novel strategy to investigate phonological assembly. Participants performed a visual lexical decision task in English in which the letters in words and letterstrings were delivered either sequentially (promoting phonological assembly) or simultaneously (not promoting phonological assembly). A region of interest analysis confirmed that regions previously associated with phonological assembly, in studies contrasting different word types (e.g. words versus pseudowords), were also identified using our novel task that controls for a number of confounding variables. Specifically, the left pars opercularis, the superior part of the ventral precentral gyrus and the supramarginal gyrus were all recruited more during sequential delivery than simultaneous delivery, even when various psycholinguistic characteristics of the stimuli were controlled. This suggests that sequential delivery of orthographic stimuli is a useful tool to explore how readers, with various levels of proficiency, use sublexical phonological processing during visual word recognition
Measurement of the differential branching fraction of the decay Λb0→Λμ+μ−

AbstractThe differential branching fraction of the decay Λb0→Λμ+μ− is measured as a function of the square of the dimuon invariant mass, q2. A yield of 78±12 Λb0→Λμ+μ− decays is observed using data, corresponding to an integrated luminosity of 1.0 fb−1, collected by the LHCb experiment at a centre-of-mass energy of 7 TeV. A significant signal is found in the q2 region above the square of the J/ψ mass, while at lower-q2 values upper limits are set on the differential branching fraction. Integrating the differential branching fraction over q2, while excluding the J/ψ and ψ(2S) regions, gives a branching fraction of B(Λb0→Λμ+μ−)=(0.96±0.16(stat)±0.13(syst)±0.21(norm))×10−6, where the uncertainties are statistical, systematic and due to the normalisation mode, Λb0→J/ψΛ, respectively
Gauge invariant Lagrangian formulation of massive higher spin fields in (A)dS3 space

AbstractWe develop the frame-like formulation of massive bosonic higher spin fields in the case of three-dimensional (A)dS space with the arbitrary cosmological constant. The formulation is based on gauge invariant description by involving the Stueckelberg auxiliary fields. The explicit form of the Lagrangians and the gauge transformation laws are found. The theory can be written in terms of gauge invariant objects similar to the massless theories, thus allowing us to hope to use the same methods for investigation of interactions. In the massive spin 3 field example we are able to rewrite the Lagrangian using the new the so-called separated variables, so that the study of Lagrangian formulation reduces to finding the Lagrangian containing only half of the fields. The same construction takes places for arbitrary integer spin field as well. Further working in terms of separated variables, we build Lagrangian for arbitrary integer spin and write it in terms of gauge invariant objects. Also, we demonstrate how to restore the full set of variables, thus receiving Lagrangian for the massive fields of arbitrary spin in the terms of initial fields
Subclinical Thyroid Dysfunction, Cardiac Function, and the Risk of Heart Failure The Cardiovascular Health Study

ObjectivesThe goal of this study was to determine whether subclinical thyroid dysfunction was associated with incident heart failure (HF) and echocardiogram abnormalities.BackgroundSubclinical hypothyroidism and hyperthyroidism have been associated with cardiac dysfunction. However, long-term data on the risk of HF are limited.MethodsWe studied 3,044 adults ≥65 years of age who initially were free of HF in the Cardiovascular Health Study. We compared adjudicated HF events over a mean 12-year follow-up and changes in cardiac function over the course of 5 years among euthyroid participants, those with subclinical hypothyroidism (subdivided by thyroid-stimulating hormone [TSH] levels: 4.5 to 9.9, ≥10.0 mU/l), and those with subclinical hyperthyroidism.ResultsOver the course of 12 years, 736 participants developed HF events. Participants with TSH ≥10.0 mU/l had a greater incidence of HF compared with euthyroid participants (41.7 vs. 22.9 per 1,000 person years, p = 0.01; adjusted hazard ratio: 1.88; 95% confidence interval: 1.05 to 3.34). Baseline peak E velocity, which is an echocardiographic measurement of diastolic function associated with incident HF in the CHS cohort, was greater in those patients with TSH ≥10.0 mU/l compared with euthyroid participants (0.80 m/s vs. 0.72 m/s, p = 0.002). Over the course of 5 years, left ventricular mass increased among those with TSH ≥10.0 mU/l, but other echocardiographic measurements were unchanged. Those patients with TSH 4.5 to 9.9 mU/l or with subclinical hyperthyroidism had no increase in risk of HF.ConclusionsCompared with euthyroid older adults, those adults with TSH ≥10.0 mU/l have a moderately increased risk of HF and alterations in cardiac function but not older adults with TSH <10.0 mU/l. Clinical trials should assess whether the risk of HF might be ameliorated by thyroxine replacement in individuals with TSH ≥10.0 mU/l