pinecone/core-2020-05-10-deduplication huggingface dataset:
Data for proteomic analysis of murine cardiomyocytic HL1 cells treated with siRNA against tissue factor

YesThis data article is related to the research article entitled Proteomics of Tissue Factor silencing in cardiomyocytic cells reveals a new role for this coagulation factor in splicing machinery control by Lento et al [1].
Tissue Factor (TF) is the key player in the coagulation cascade, but it has additional functions ranging from angiogenesis, tumor invasion and, in the heart, the maintenance of the integrity of cardiac cells. This article reports the nano-LC-MSE analysis of the cardiomyocytic HL-1 cell line proteome and describes the results obtained from a Gene Ontology analysis of those proteins affected by TF-gene silencing
Flavon-induced connections between lepton flavour mixing and charged lepton flavour violation processes.

In leptonic flavour models with discrete flavour symmetries, couplings between flavons and leptons can result in special flavour structures after they gain vacuum expectation values. At the same time, they can also contribute to the other lepton-flavour-violating processes. We study the flavon-induced LFV 3-body charged lepton decays and radiative decays and we take as example the A4 discrete symmetry. In A4 models, a Z3 residual symmetry roughly holds in the charged lepton sector for the realisation of tri-bimaximal mixing at leading order. The only processes allowed by this symmetry are τ− → μ+e−e−, e+μ−μ−, and the other 3-body and all radiative decays are suppressed by small Z3-breaking effects. These processes also depend on the representation the flavon is in, whether pseudo-real (case i) or complex (case ii). We calculate the decay rates for all processes for each case and derive their strong connection with lepton flavour mixing. In case i, sum rules for the branching ratios of these processes are obtained, with typical examples Br(τ− → μ+e−e−) ≈ Br(τ− → e+μ−μ−) and Br(τ− → e−γ) ≈ Br(τ− → μ−γ). In case ii, we observe that the mixing between two Z3-covariant flavons plays an important role. All processes are suppressed by charged lepton masses and current experimental con- straints allow the electroweak scale and the flavon masses to be around hundreds of GeV. Our discussion can be generalised in other flavour models with different flavour symmetries
tt∗ equations, localization and exact chiral rings in 4d\ud
N = 2 SCFTs.

We compute exact 2- and 3-point functions of chiral primaries in four-dimensional  NN  = 2 superconformal field theories, including all perturbative and instanton contributions. We demonstrate that these correlation functions are nontrivial and satisfy exact differential equations with respect to the coupling constants. These equations are the analogue of the tt* equations in two dimensions. In the SU(2)  NN  = 2 SYM theory coupled to 4 hypermultiplets they take the form of a semi-infinite Toda chain. We provide the complete solution of this chain using input from supersymmetric localization. To test our results we calculate the same correlation functions independently using Feynman diagrams up to 2-loops and we find perfect agreement up to the relevant order. As a spin-off, we perform a 2-loop check of the recent proposal of arXiv:1405.7271 that the logarithm of the sphere partition function in  NN  = 2 SCFTs determines the Kähler potential of the Zamolodchikov metric on the conformal manifold. We also present the tt* equations in general SU(N)  NN  = 2 superconformal QCD theories and comment on their structure and implications
High speed laser surface modification of Ti-6Al-4V

Titanium and its alloys have been commonly used for biomedical implant applications for many years; however, associated high coefficient of friction, wear characteristics and low hardness have limited their long term performance. This article investigates the effects of the high speed laser surface modification of Ti–6Al–4V on the microstructure, surface roughness, meltpool depth, phase transformation, residual strain, microhardness, and chemical composition. Laser treatment was carried out using a 1.5 kW CO2 laser in an argon gas environment. Irradiance and residence time were varied between 15.7 to 26.7 kW/mm2 and 1.08 to 2.16 ms respectively. Laser treatment resulted in a 20 to 50 μm thick surface modified layer without cracks. An increase in residence time and irradiance resulted in higher depth of processing. Surface roughness was found to decrease with increase in both irradiance and residence time. Metallography showed that a martensite structure formed on the laser treated region producing acicular α-Ti nested within the aged β matrix. The laser treatment reduced volume percentage of β-Ti as compared to the non-treated surface. Lattice stains in the range of 0.81% to 0.91% were observed after laser surface modification. A significant increase in microhardness was recorded for all laser treated samples. Microhardness increased up to 760 HV0.05 which represented a 67% increase compared to the bulk material. Energy Dispersive X-ray Spectroscopy (EDS) analysis showed that laser surface modification produced a more homogenous chemical composition of the alloying elements compared to the untreated bulk metal
Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.

Isocitrate dehydrogenase 1 mutations drive human gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this disease, we conditionally expressed Idh1(R132H) in the subventricular zone (SVZ) of the adult mouse brain. The mice developed hydrocephalus and grossly dilated lateral ventricles, with accumulation of 2-hydroxyglutarate and reduced α-ketoglutarate. Stem and transit amplifying/progenitor cell populations were expanded, and proliferation increased. Cells expressing SVZ markers infiltrated surrounding brain regions. SVZ cells also gave rise to proliferative subventricular nodules. DNA methylation was globally increased, while hydroxymethylation was decreased. Mutant SVZ cells overexpressed Wnt, cell-cycle and stem cell genes, and shared an expression signature with human gliomas. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis
Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis.

BACKGROUND &amp; AIMS: Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations in patient assessments of disease severity. We also evaluated relationships between patient assessment of disease severity and EoE-associated endoscopic, histologic, and laboratory findings.
METHODS: We collected information from 186 patients with EoE in Switzerland and the United States (69.4% male; median age, 43 y) via surveys (n = 135), focus groups (n = 27), and semistructured interviews (n = 24). Items were generated for the instruments to assess biologic activity based on physician input. Linear regression was used to quantify the extent to which variations in patient-reported disease characteristics could account for variations in patient assessment of EoE severity. The PRO instrument was used prospectively in 153 adult patients with EoE (72.5% male; median age, 38 y), and validated in an independent group of 120 patients with EoE (60.8% male; median age, 40.5 y).
RESULTS: Seven PRO factors that are used to assess characteristics of dysphagia, behavioral adaptations to living with dysphagia, and pain while swallowing accounted for 67% of the variation in patient assessment of disease severity. Based on statistical consideration and patient input, a 7-day recall period was selected. Highly active EoE, based on endoscopic and histologic findings, was associated with an increase in patient-assessed disease severity. In the validation study, the mean difference between patient assessment of EoE severity (range, 0-10) and PRO score (range, 0-8.52) was 0.15.
CONCLUSIONS: We developed and validated an EoE scoring system based on 7 PRO items that assess symptoms over a 7-day recall period. Clinicaltrials.gov number: NCT00939263
Sustainable venture capital - catalyst for sustainable start-up success?

To address global sustainability challenges, major investments are required in sustainable businesses that deliver triple bottom line results. Although interest in sustainable businesses is on the rise, these businesses are not yet widespread. Venture capital investment has a key role to play in the development of sustainable start-ups. The research area of ‘sustainable’ venture capital is still emerging. More research is required to understand how venture capital can support the development of sustainable businesses. This paper provides insight into how venture capitalists can contribute to sustainable business success, by investigating their role, motivations, investment theses, and barriers and enablers to success of sustainable ventures. The following question is investigated: How can sustainable venture capitalists contribute to the success of sustainable start-ups? Interviews were conducted with an expert sample of leading sustainable venture capitalists and other key stakeholders in sustainable entrepreneurship. It was found that next to financial support, venture capitalists provide triple bottom line business advice and network support. Key success factors include business model innovation, collaborations and a strong business case, whereas failure factors include a lack of suitable investors, a strong incumbent industry and a short-term investor mind-set. Sustainable start-ups should focus on triple bottom line business model innovation, find opportunity in new technology and funding platforms and develop multiple business cases to create success beyond the ‘green customer base’. Sustainable venture capitalists can help prove the success of sustainable business formats, mitigate financial risk through co-investments and exercise patience by balancing financial with social and environmental returns.The author gratefully acknowledges the support and funding of the EPSRC Centre for Innovative Manufacturing in Industrial Sustainability (RG64858).This is the final version. It was first published by Elsevier at http://dx.doi.org/10.1016/j.jclepro.2015.05.07
Search for new physics in events with same-sign dileptons and jets in pp collisions at √s = 8 TeV

A search for new physics is performed based on events with jets and a pair of isolated, same-sign leptons. The results are obtained using a sample of proton-proton collision data collected by the CMS experiment at a centre-of-mass energy of 8 TeV at the LHC, corresponding to an integrated luminosity of 19.5 fb[superscript −1]. In order to be sensitive to a wide variety of possible signals beyond the standard model, multiple search regions defined by the missing transverse energy, the hadronic energy, the number of jets and b-quark jets, and the transverse momenta of the leptons in the events are considered. No excess above the standard model background expectation is observed and constraints are set on a number of models for new physics, as well as on the same-sign top-quark pair and quadruple-top-quark production cross sections. Information on event selection efficiencies is also provided, so that the results can be used to confront an even broader class of new physics models.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio
Search for associations containing young stars (SACY). VII. New stellar and substellar candidate members in the young associations

Context. The young associations offer us one of the best opportunities to study the properties of young stellar and substellar objects and to directly image planets thanks to their proximity (<200 pc) and age (≈5−150 Myr). However, many previous works have been limited to identifying the brighter, more active members (≈1 M_⊙) owing to photometric survey sensitivities limiting the detections of lower mass objects. Aims. We search the field of view of 542 previously identified members of the young associations to identify wide or extremely wide (1000−100 000 au in physical separation) companions. Methods. We combined 2MASS near-infrared photometry (J, H, K) with proper motion values (from UCAC4, PPMXL, NOMAD) to identify companions in the field of view of known members. We collated further photometry and spectroscopy from the literature and conducted our own high-resolution spectroscopic observations for a subsample of candidate members. This complementary information allowed us to assess the efficiency of our method. Results. We identified 84 targets (45: 0.2−1.3 M_⊙, 17: 0.08−0.2 M_⊙, 22: <0.08 M_⊙) in our analysis, ten of which have been identified from spectroscopic analysis in previous young association works. For 33 of these 84, we were able to further assess their membership using a variety of properties (X-ray emission, UV excess, Hα, lithium and K I equivalent widths, radial velocities, and CaH indices). We derive a success rate of 76–88% for this technique based on the consistency of these properties. Conclusions. Once confirmed, the targets identified in this work would significantly improve our knowledge of the lower mass end of the young associations. Additionally, these targets would make an ideal new sample for the identification and study of planets around nearby young stars. Given the predicted substellar mass of the majority of these new candidate members and their proximity, high-contrast imaging techniques would facilitate the search for new low-mass planets
Centrality and rapidity dependence of inclusive jet production in root sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Measurements of the centrality and rapidity dependence of inclusive jet production in √sNN = 5.02 TeV proton–lead (p+Pb) collisions and the jet cross-section √s = 2.76 TeV proton–proton collisions are presented. These quantities are measured in datasets corresponding to an integrated luminosity of 27.8 nb⁻¹and 4.0 pb⁻¹, respectively, recorded with the ATLAS detector at the Large Hadron Collider in 2013. The p+Pb collision centrality was characterised using the total transverse energy measured in the pseudorapidity interval −4.9<η<−3.2 in the direction of the lead beam. Results are presented for the double-differential per-collision yields as a function of jet rapidity and transverse momentum (pT) for minimum-bias and centrality-selected p+Pb collisions, and are compared to the jet rate from the geometric expectation. The total jet yield in minimum-bias events is slightly enhanced above the expectation in a pT-dependent manner but is consistent with the expectation within uncertainties. The ratios of jet spectra from different centrality selections show a strong modification of jet production at all pT at forward rapidities and for large pTpT at mid-rapidity, which manifests as a suppression of the jet yield in central events and an enhancement in peripheral events. These effects imply that the factorisation between hard and soft processes is violated at an unexpected level in proton–nucleus collisions. Furthermore, the modifications at forward rapidities are found to be a function of the total jet energy only, implying that the violations may have a simple dependence on the hard parton–parton kinematics.G. Aad ... P. Jackson ... L. Lee ... A. Petridis ... N. Soni ... M.J. White ... et al. (ATLAS Collaboration
Measurement of the absolute differential cross section of proton–proton elastic scattering at small angles

The differential cross section for proton–proton elastic scattering has been measured at a beam kinetic energy of 1.0 GeV and in 200 MeV steps from 1.6 to 2.8 GeV for centre-of-mass angles in the range from 12°–16° to 25°–30°, depending on the energy. A precision in the overall normalisation of typically 3% was achieved by studying the energy losses of the circulating beam of the COSY storage ring as it passed repeatedly through the windowless hydrogen target of the ANKE magnetic spectrometer. It is shown that the data have a significant impact upon the results of a partial wave analysis. After extrapolating the differential cross sections to the forward direction, the results are broadly compatible with the predictions of forward dispersion relations
Search for invisible decays of a Higgs boson using vector-boson fusion in pp collisions at √s = 8 TeV with the ATLAS detector

Journal of High Energy Physics 2016.1 (2016): 172 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)Artículo escrito por un elevado número de autores, sólo se referencian el nombre del que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere y los autores que firman como pertenecientes a la UAMA search for a Higgs boson produced via vector-boson fusion and decaying into invisible particles is presented, using 20.3 fb−1 of proton-proton collision data at a centreof-mass energy of 8 TeV recorded by the ATLAS detector at the LHC. For a Higgs boson with a mass of 125 GeV, assuming the Standard Model production cross section, an upper bound of 0.28 is set on the branching fraction of H → invisible at 95% confidence level, where the expected upper limit is 0.31. The results are interpreted in models of Higgsportal dark matter where the branching fraction limit is converted into upper bounds on the dark-matter-nucleon scattering cross section as a function of the dark-matter particle mass, and compared to results from the direct dark-matter detection experimentsWe thank CERN for the very successful operation of the LHC, as well as the support staff_from our institutions without whom ATLAS could not be operated efficiently.
We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia;
BMWF, Austria; AHAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil;
NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC,
China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic;
DNRF, DNSRC and Lundbeck Foundation, Denmark; ARTEMIS, European Union;
IN2P3-CNRS, CEA-DSM/IRFU, France; GNAS, Georgia; BMBF, DFG, HGF, MPG and
AvH Foundation, Germany; GSRT, Greece; ISF, MINERVA, GIF, DIP and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America.
The crucial computing support from all WLCG partners is acknowledged gratefully,
in particular from CERN and the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF
(Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF
(Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (U.K.) and BNL
(U.S.A.) and in the Tier-2 facilities worldwid
Efficiency and Security of Process Transparency in Production Networks—A View of Expectations, Obstacles and Potentials

AbstractMuch of the resilience and flexibility of production networks lies in the transparency of processes that allows timely perception of actual process states and adequate decisions or intervention at the proper point of the production system. Such degree of observability and permeability do, however, bear risks of malevolent tapping or interference with the information stream which, in the case of production systems, can put both business and physical processes at risk, requiring careful exploration of security threats in horizontal and vertical integration, and individual end-to-end connections likewise. Also, different levels of networked production present specific needs—high throughput and low time lag on the shop-floor level, or tolerances for confidence, gambling and bounded-rational views in cross-company relations—that may conflict with security policies. The paper presents a systematic summary of such apparently contradicting preferences, and possible approaches of reconciliation currently perceived to be relevant on various abstraction levels of production networks
Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial

SummaryBackgroundMechanical chest compression devices have the potential to help maintain high-quality cardiopulmonary resuscitation (CPR), but despite their increasing use, little evidence exists for their effectiveness. We aimed to study whether the introduction of LUCAS-2 mechanical CPR into front-line emergency response vehicles would improve survival from out-of-hospital cardiac arrest.MethodsThe pre-hospital randomised assessment of a mechanical compression device in cardiac arrest (PARAMEDIC) trial was a pragmatic, cluster-randomised open-label trial including adults with non-traumatic, out-of-hospital cardiac arrest from four UK Ambulance Services (West Midlands, North East England, Wales, South Central). 91 urban and semi-urban ambulance stations were selected for participation. Clusters were ambulance service vehicles, which were randomly assigned (1:2) to LUCAS-2 or manual CPR. Patients received LUCAS-2 mechanical chest compression or manual chest compressions according to the first trial vehicle to arrive on scene. The primary outcome was survival at 30 days following cardiac arrest and was analysed by intention to treat. Ambulance dispatch staff and those collecting the primary outcome were masked to treatment allocation. Masking of the ambulance staff who delivered the interventions and reported initial response to treatment was not possible. The study is registered with Current Controlled Trials, number ISRCTN08233942.FindingsWe enrolled 4471 eligible patients (1652 assigned to the LUCAS-2 group, 2819 assigned to the control group) between April 15, 2010 and June 10, 2013. 985 (60%) patients in the LUCAS-2 group received mechanical chest compression, and 11 (<1%) patients in the control group received LUCAS-2. In the intention-to-treat analysis, 30 day survival was similar in the LUCAS-2 group (104 [6%] of 1652 patients) and in the manual CPR group (193 [7%] of 2819 patients; adjusted odds ratio [OR] 0·86, 95% CI 0·64–1·15). No serious adverse events were noted. Seven clinical adverse events were reported in the LUCAS-2 group (three patients with chest bruising, two with chest lacerations, and two with blood in mouth). 15 device incidents occurred during operational use. No adverse or serious adverse events were reported in the manual group.InterpretationWe noted no evidence of improvement in 30 day survival with LUCAS-2 compared with manual compressions. On the basis of ours and other recent randomised trials, widespread adoption of mechanical CPR devices for routine use does not improve survival.FundingNational Institute for Health Research HTA – 07/37/69
Baryogenesis and asymmetric dark matter from the left–right mirror symmetric model

AbstractThe paper suggests a left–right mirror symmetric model to account for the baryogenesis and asymmetric dark matter. The model can simultaneously accommodate the standard model, neutrino physics, matter–antimatter asymmetry and dark matter. In particular, it naturally and elegantly explains the origin of the baryon and dark matter asymmetries, and clearly gives the close interrelations of them. In addition, the model predicts a number of interesting results, e.g. that the cold dark matter neutrino mass is 3.1 times the proton mass. It is also feasible and promising to test the model in future experiments