pinecone/core-2020-05-10-deduplication huggingface dataset:
Minimal unitary representation of 5d superconformal algebra F(4) and AdS6/CFT5 higher spin (super)-algebras

AbstractWe study the minimal unitary representation (minrep) of SO(5,2), obtained by quantization of its geometric quasiconformal action, its deformations and supersymmetric extensions. The minrep of SO(5,2) describes a massless conformal scalar field in five dimensions and admits a unique “deformation” which describes a massless conformal spinor. Scalar and spinor minreps of SO(5,2) are the 5d analogs of Dirac's singletons of SO(3,2). We then construct the minimal unitary representation of the unique 5d superconformal algebra F(4) with the even subalgebra SO(5,2)×SU(2). The minrep of F(4) describes a massless conformal supermultiplet consisting of two scalar and one spinor fields. We then extend our results to the construction of higher spin AdS6/CFT5 (super)-algebras. The Joseph ideal of the minrep of SO(5,2) vanishes identically as operators and hence its enveloping algebra yields the AdS6/CFT5 bosonic higher spin algebra directly. The enveloping algebra of the spinor minrep defines a “deformed” higher spin algebra for which a deformed Joseph ideal vanishes identically as operators. These results are then extended to the construction of the unique higher spin AdS6/CFT5 superalgebra as the enveloping algebra of the minimal unitary realization of F(4) obtained by the quasiconformal methods
The lipid composition of a cell membrane modulates the interaction of an antiparasitic peptide at the air–water interface

AbstractThe antiparasitic property of peptides is believed to be associated with their interactions with the protozoan membrane, which calls for research on the identification of membrane sites capable of peptide binding. In this study we investigated the interaction of a lipophilic glutathioine peptide known to be effective against the African Sleeping Sickness (ASS — African Trypanosomiasis) and cell membrane models represented by Langmuir monolayers. It is shown that even small amounts of the peptide affect the monolayers of some phospholipids and other lipids, which points to a significant interaction. The latter did not depend on the electrical charge of the monolayer-forming molecules but the peptide action was particularly distinctive for cholesterol + sphingomyelin monolayers that roughly resemble rafts on a cell membrane. Using in situ polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS), we found that the orientation of the peptide is affected by the phospholipids and dioctadecyldimethylammonium bromide (DODAB), but not in monolayers comprising cholesterol + sphingomyelin. In this mixed monolayer resembling rafts, the peptide still interacts and has some induced order, probably because the peptide molecules are fitted together into a compact monolayer. Therefore, the lipid composition of the monolayer modulates the interaction with the lipophilic glutathioine peptide, and this may have important implications in understanding how the peptide acts on specific sites of the protozoan membrane
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

SummaryBackgroundRaised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher.MethodsFor this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure.FindingsWe pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and southeast Asia, south Asia, Oceania, and sub-Saharan Africa. In 2015, central and eastern Europe, sub-Saharan Africa, and south Asia had the highest blood pressure levels. Prevalence of raised blood pressure decreased in high-income and some middle-income countries; it remained unchanged elsewhere. The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries. The global increase in the number of adults with raised blood pressure is a net effect of increase due to population growth and ageing, and decrease due to declining age-specific prevalence.InterpretationDuring the past four decades, the highest worldwide blood pressure levels have shifted from high-income countries to low-income countries in south Asia and sub-Saharan Africa due to opposite trends, while blood pressure has been persistently high in central and eastern Europe.FundingWellcome Trust
Numerical methods and analysis for a class of fractional advection–dispersion models

AbstractIn this paper, a class of fractional advection–dispersion models (FADMs) is considered. These models include five fractional advection–dispersion models, i.e., the time FADM, the mobile/immobile time FADM with a time Caputo fractional derivative 0<γ<1, the space FADM with two sides Riemann–Liouville derivatives, the time–space FADM and the time fractional advection–diffusion-wave model with damping with index 1<γ<2. These equations can be used to simulate the regional-scale anomalous dispersion with heavy tails. We propose computationally effective implicit numerical methods for these FADMs. The stability and convergence of the implicit numerical methods are analysed and compared systematically. Finally, some results are given to demonstrate the effectiveness of theoretical analysis
Geochemical and palynological sea-level proxies in hemipelagic sediments: A critical assessment from the Upper Cretaceous of the Czech Republic

AbstractGeochemical and palynological records are presented for an expanded Turonian–Coniacian hemipelagic succession in the central Bohemian Cretaceous Basin. A high-resolution stratigraphic framework is provided by biostratigraphy and organic carbon stable-isotope (δ13Corg) chemostratigraphy. A short-term (100 kyr) sea-level curve has been derived from high-resolution transgressive/regressive maxima / shore-proximity data established from basin-wide sediment geometries. The viability of geochemical and palynological parameters as potential sea-level proxies is tested against this independently derived sea-level record. Elemental chemostratigraphy is demonstrated to offer a reliable means of identifying medium- to long-term (0.4–2.4 Myr) sea-level trends. Manganese maxima are associated with periods of high sea level, and troughs with intervals of low sea level. Falling Mn contents accompany regression and rising values transgression. Major transgressive events associated with medium-term sea-level change are marked by sharp increases in Ti/Al ratios, but short-term (100 kyr) sea-level cycles are not consistently identified. Long-term δ13Corg variation and dinoflagellate cyst species richness are positively correlated and show similarities to the sea-level curve. Baseline trends have a cycle duration close to the 2.4 Myr long-eccentricity cycle. Dinocyst species richness closely follows short-term changes in sea level, with marked increases in dinocyst diversity coincident with most short-term flooding events. Periods of rapid sea-level rise caused an influx of a more diverse ‘outer shelf’ assemblage into the study area, together with the addition of shallower water species, some of which may have been transported into the central basin by hypopycnal flows. Changes in the proportion and abundance of peridinioid dinoflagellate cysts (principally Palaeohystrichophora infusorioides) were controlled principally by changing nutrient levels. Proximity proxies derived from geochemical and palynological data are not always consistent with the independent sea-level model. This exemplifies the need to understand all factors influencing elemental geochemical and palynological proxies before making simplistic sea level interpretations
Issues with Phase Space Characterization of Laser-plasma Generated Electron Beams

AbstractPlasma acceleration is the new frontier in particle beam accelerators. Using the strong electric fields inside a plasma it is possible to achieve accelerating gradients orders of magnitude larger with respect to current technologies. Different schemes, using completely different approaches, have been proposed and several already tested, producing beams of energy up to several GeV. Regardless of the technique used for acceleration a precise determination of the output beam parameters is mandatory for the fine tuning of the process. The measurement of these parameters, in particular the beam distribution in transverse and longitudinal phase space, is not trivial, mainly due to the large energy spread and to the tight focusing of these beams or to the background noise produced in the plasma channel. We illustrate the main problems related to the diagnostic of this kind of beams and some of the proposed or already realized solution
Comparison on efficiency of various techniques in treatment of waste and sewage water – A comprehensive review

AbstractIn the present scenario, environmental laws have become stringent towards health, economy and reduction of pollution. The pollution is a result of discharge of various organic and inorganic substances into the environment. The sources of pollution include domestic agricultural and industrial water. Conventional techniques such as chemical precipitation, carbon adsorption, ion exchange, evaporations and membrane processes are found to be effective in treatment of waste and sewage water. Recently, biological treatments have gained popularity to remove toxic and other harmful substances. The objective of the paper is to make comprehensive review including the performance of each technique in treatment of waste and sewage water. The research directions are also suggested based on the review
Antiacanthamoebic properties of natural and marketed honey in Pakistan

AbstractObjectiveTo determine antiacanthamoebic activity of natural and marketed honey samples.MethodsNatural honey samples were collected directly from the bee hive and marketed honey samples were purchased from the local market in Karachi, Pakistan. Both honey samples were tested for their flavonoid content (quercetin equivalent per gram of the extract) and phenolic content (gallic acid equivalent per gram). Furthermore, their antioxidant activity was determined by measuring 2,2-diphenyl-1-picrylhydrazyl. Using amoebistatic and amoebicidal assays, the effects of honey samples were tested against growth and viability of Acanthamoeba parasites.ResultsNatural honey exhibited potent amoebistatic and amoebicidal effects, in a concentration-dependent manner. Honey-treated Acanthamoeba castellanii showed loss of acanthopodia, following which amoebae detached, rounded up, reduced in size, decreased in cytoplasmic mass and they were observed floating in the culture medium. Importantly, honey-treated amoebae did not revive when inoculated in fresh growth medium, however, glycerol-treated amoebae exhibited viable trophozoite and active growth. In contrast, marketed honey samples varied in their efficacy against Acanthamoeba castellanii. The proportion of flavonoid, as determined by quercetin measurements and the proportion of phenolic, as determined by gallic acid measurements was higher in natural honey compared with marketed honey. Similarly, the antioxidant activity, as determined by 2,2-diphenyl-1-picrylhydrazyl scavenging activity was higher in natural honey vs. marketed honey.ConclusionsThis study shows that natural honey has antiacanthamoebic properties and possesses higher flavonoid, phenolic and antioxidant properties compared with the marketed honey. These findings are of concern to the public, health officials, and to the manufacturers regarding production of honey for medical applications
On the low regularity of the fifth order Kadomtsev–Petviashvili I equation

AbstractWe consider the fifth order Kadomtsev–Petviashvili I (KP-I) equation as ∂tu+α∂x3u+∂x5u+∂x−1∂y2u+uux=0, while α∈R. We introduce an interpolated energy space Es to consider the well-posedness of the initial value problem (IVP) of the fifth order KP-I equation. We obtain the local well-posedness of IVP of the fifth order KP-I equation in Es for 0<s⩽1. To obtain the local well-posedness, we present a bilinear estimate in the Bourgain space in the framework of the interpolated energy space. It crucially depends on the dyadic decomposed Strichartz estimate, the fifth order dispersive smoothing effect and maximal estimate
Search for black holes and other new phenomena in high-multiplicity
  final states in proton-proton collisions at sqrt(s) = 13 TeV

A search for new physics in energetic, high-multiplicity final states has
been performed using proton-proton collision data collected with the CMS
detector at a center-of-mass energy of 13 TeV and corresponding to an
integrated luminosity of 2.3 inverse femtobarns. The standard model background,
dominated by multijet production, is determined exclusively from control
regions in data. No statistically significant excess of events is observed.
Model-independent limits on the product of the cross section and the acceptance
of a new physics signal in these final states are set and further interpreted
in terms of limits on the production of black holes. Semiclassical black holes
and string balls with masses as high as 9.5 TeV, and quantum black holes with
masses as high as 9.0 TeV are excluded by this search in the context of models
with extra dimensions, thus significantly extending limits set at a
center-of-mass energy of 8 TeV with the LHC Run 1 data.Comment: Replaced with the published version. Added the journal reference and
  DOI. All the figures and tables can be found at
  http://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-15-007
  (CMS Public Pages
Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d

Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic alpha-galactosylceramide, they produce a vast amount of cytokines. Here we present a synthesis that allows swift modification of the phytosphingosine side chain by amidation of an advanced methyl ester precursor. The resulting KRN7000 derivatives, termed alpha-galactosylsphingamides, were evaluated for their capacity to stimulate iNKT-cells. While introduction of the amide-motif in the phytosphingosine chain is tolerated for CD1d binding and TCR recognition, the studied alpha-galactosylsphingamides showed compromised antigenic properties
Liver fibrosis in treatment-naïve HIV-infected and HIV/HBV co-infected patients: Zambia and Switzerland compared.

To examine the association between hepatitis B virus (HBV) infection and liver fibrosis in HIV-infected patients in Zambia and Switzerland.
HIV-infected adults starting antiretroviral therapy in two clinics in Zambia and Switzerland were included. Liver fibrosis was evaluated using the aspartate aminotransferase-to-platelet-ratio index (APRI), with a ratio &gt;1.5 defining significant fibrosis and a ratio &gt;2.0 indicating cirrhosis. The association between hepatitis B surface antigen (HBsAg) positivity, HBV replication, and liver fibrosis was examined using logistic regression.
In Zambia, 96 (13.0%) of 739 patients were HBsAg-positive compared to 93 (4.5%) of 2058 in Switzerland. HBsAg-positive patients were more likely to have significant liver fibrosis than HBsAg-negative ones: the adjusted odds ratio (aOR) was 3.25 (95% confidence interval (CI) 1.44-7.33) in Zambia and 2.50 (95% CI 1.19-5.25) in Switzerland. Patients with a high HBV viral load (≥20000 IU/ml) were more likely to have significant liver fibrosis compared to HBsAg-negative patients or patients with an undetectable viral load: aOR 3.85 (95% CI 1.29-11.44) in Zambia and 4.20 (95% CI 1.64-10.76) in Switzerland. In both settings, male sex was a strong risk factor for significant liver fibrosis.
Despite the differences in HBV natural history between Sub-Saharan Africa and Europe, the degree of liver fibrosis and the association with important risk factors were similar
Current evidence and future perspectives on HuR and breast cancer development, prognosis, and treatment.

This is the Accepted Manuscript version of the following article, "Ioly Kotta-Loizou, et al., ???Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment???, Neoplasia, Vol. 18(11): 674-688, October 2016." The final published version is available at:https://doi.org/10.1016/j.neo.2016.09.002 Copyright ?? 2016, Elsevier.Hu-antigen R (HuR) is an RNA-binding posttranscriptional regulator that belongs to the Hu/ELAV family. HuR expression levels are modulated by a variety of proteins, microRNAs, chemical compounds, or the microenvironment, and in turn, HuR affects mRNA stability and translation of various genes implicated in breast cancer formation, progression, metastasis, and treatment. The aim of the present review is to critically summarize the role of HuR in breast cancer development and its potential as a prognosticator and a therapeutic target. In this aspect, all the existing English literature concerning HuR expression and function in breast cancer cell lines, in vivo animal models, and clinical studies is critically presented and summarized. HuR modulates many genes implicated in biological processes crucial for breast cancer formation, growth, and metastasis, whereas the link between HuR and these processes has been demonstrated directly in vitro and in vivo. Additionally, clinical studies reveal that HuR is associated with more aggressive forms of breast cancer and is a putative prognosticator for patients' survival. All the above indicate HuR as a promising drug target for cancer therapy; nevertheless, additional studies are required to fully understand its potential and determine against which types of breast cancer and at which stage of the disease a therapeutic agent targeting HuR would be more effective
Stellar physical parameters from Str ??mgren photometry. Application to the young stars in the Galactic anticenter survey

M. Mongui??, F. Figueras, and P. Grosb??l, ???Stellar physical parameters from Str??mgren photometry. Application to the young stars in the Galactic anticenter survey???, Astronomy & Astrophysics, Vol. 568, September 2014. Thhis version of record is available online at: https://doi.org/10.1051/0004-6361/201423703 Reproduced with Permission from Astronomy and Astrophysics, ?? ESO 2016.Aims. The aim is to derive accurate stellar distances and extinctions for young stars of our survey in the Galactic anticenter direction using the Str\"omgren photometric system. This will allow a detailed mapping of the stellar density and absorption toward the Perseus arm. Methods. We developed a new method for deriving physical parameters from Str\"omgren photometry and also implemented and tested it. This is a model-based method that uses the most recent available stellar atmospheric models and evolutionary tracks to interpolate in a 3D grid of the unreddened indexes [m1], [c1] and Hbeta. Distances derived from both this method and the classical pre-Hipparcos calibrations were tested against Hipparcos parallaxes and found to be accurate. Results. Systematic trends in stellar photometric distances derived from empirical calibrations were detected and quantified. Furthermore, a shift in the atmospheric grids in the range Teff=[7000,9000]K was detected and a correction is proposed. The two methods were used to compute distances and reddening for about 12000 OBA-type stars in our Str\"omgren anticenter survey. Data from the IPHAS and 2MASS catalogs were used to complement the detection of emission line stars and to break the degeneracy between early and late photometric regions. We note that photometric distances can differ by more than 20%, those derived from the empirical calibrations being smaller than those derived with the new method, which agree better with the Hipparcos data
Routes Obey Hierarchy in Complex Networks.

The last two decades of network science have discovered stunning similarities in the topological characteristics of real life networks (many biological, social, transportation and organizational networks) on a strong empirical basis. However our knowledge about the operational paths used in these networks is very limited, which prohibits the proper understanding of the principles of their functioning. Today, the most widely adopted hypothesis about the structure of the operational paths is the shortest path assumption. Here we present a striking result that the paths in various networks are significantly stretched compared to their shortest counterparts. Stretch distributions are also found to be extremely similar. This phenomenon is empirically confirmed on four networks from diverse areas of life. We also identify the high-level path selection rules nature seems to use when picking its paths
Search for diphoton events with large missing transverse momentum in 7
  TeV proton-proton collision data with the ATLAS detector

A search for diphoton events with large missing transverse momentum has been
performed using proton-proton collision data at sqrt(s) = 7 TeV recorded with
the ATLAS detector, corresponding to an integrated luminosity of 4.8 fb^-1. No
excess of events was observed above the Standard Model prediction and
model-dependent 95% confidence level exclusion limits are set. In the context
of a generalised model of gauge-mediated supersymmetry breaking with a
bino-like lightest neutralino of mass above 50 GeV, gluinos (squarks) below
1.07 TeV (0.87 TeV) are excluded, while a breaking scale Lambda below 196 TeV
is excluded for a minimal model of gauge-mediated supersymmetry breaking. For a
specific model with one universal extra dimension, compactification scales 1/R
< 1.40 TeV are excluded. These limits provide the most stringent tests of these
models to date.Comment: 10 pages plus author list (23 pages total), 9 figures, 4 tables,
  submitted to Physics Letters