pinecone/core-2020-05-10-deduplication huggingface dataset:
NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma

BackgroundBronchial epithelial ciliary dysfunction is an important feature of asthma. We sought to determine the role in asthma of neutrophilic inflammation and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases in ciliary dysfunction.MethodsBronchial epithelial ciliary function was assessed by using video microscopy in fresh ex vivo epithelial strips from patients with asthma stratified according to their sputum cell differentials and in culture specimens from healthy control subjects and patients with asthma. Bronchial epithelial oxidative damage was determined by 8-oxo-dG expression. Nicotinamide adenine dinucleotide phosphate oxidase (NOX)/dual oxidase (DUOX) expression was assessed in bronchial epithelial cells by using microarrays, with NOX4 and DUOX1/2 expression assessed in bronchial biopsy specimens. Ciliary dysfunction following NADPH oxidase inhibition, using GKT137831, was evaluated in fresh epithelial strips from patients with asthma and a murine model of ovalbumin sensitization and challenge.ResultsCiliary beat frequency was impaired in patients with asthma with sputum neutrophilia (n = 11) vs those without (n = 10) (5.8 [0.6] Hz vs 8.8 [0.5] Hz; P = .003) and was correlated with sputum neutrophil count (r = –0.70; P < .001). Primary bronchial epithelial cells expressed DUOX1/2 and NOX4. Levels of 8-oxo-dG and NOX4 were elevated in patients with neutrophilic vs nonneutrophilic asthma, DUOX1 was elevated in both, and DUOX2 was elevated in nonneutrophilic asthma in vivo. In primary epithelial cultures, ciliary dysfunction did not persist, although NOX4 expression and reactive oxygen species generation was increased from patients with neutrophilic asthma. GKT137831 both improved ciliary function in ex vivo epithelial strips (n = 13), relative to the intensity of neutrophilic inflammation, and abolished ciliary dysfunction in the murine asthma model with no reduction in inflammation.ConclusionsCiliary dysfunction is increased in neutrophilic asthma associated with increased NOX4 expression and is attenuated by NADPH oxidase inhibition
A new Lenstra-type algorithm for quasiconvex polynomial integer minimization with complexity 2O(nlogn)

AbstractWe study the integer minimization of a quasiconvex polynomial with quasiconvex polynomial constraints. We propose a new algorithm that is an improvement upon the best known algorithm due to Heinz [S. Heinz, Complexity of integer quasiconvex polynomial optimization, Journal of Complexity 21(4) (2005) 543–556]. This improvement is achieved by applying a new modern Lenstra-type algorithm, finding optimal ellipsoid roundings, and considering sparse encodings of polynomials. For the bounded case, our algorithm attains a time-complexity of s(rlMd)O(1)22nlog2(n)+O(n) when M is a bound on the number of monomials in each polynomial and r is the binary encoding length of a bound on the feasible region. In the general case, slO(1)dO(n)22nlog2(n)+O(n). In each we assume d≥2 is a bound on the total degree of the polynomials and l bounds the maximum binary encoding size of the input
Pheochromocytoma as a rare cause of arterial hypertension in a patient with autosomal dominant polycystic kidney disease: A diagnostic and therapeutic dilemma

AbstractIntroductionIndividuals with autosomal dominant polycystic kidney disease (ADPKD) frequently suffer arterial hypertension even prior to significant loss of renal function, a clinical situation that obscures detection of modifiable secondary causes of hypertension.Presentation of caseA 50-year-old man with ADPKD and polycystic liver and resistant hypertension is diagnosed with a 4-cm right adrenal mass. Cross-sectional MRI is indicative of pheochromocytoma versus adrenocortical carcinoma or metastasis, though there are no typical PCC symptoms and plasma and urine metanephrines are within normal ranges. Since malignancy cannot be excluded, right adrenalectomy is performed. Considering that the enlarged liver poses an obstacle for transperitoneal open and laparoscopic approaches, a retroperitoneoscopic approach is used. Surgical pathology reveals a 4.5-cm pheochromocytoma; the patient no longer requires antihypertensive therapy.Discussion & conclusionPheochromocytoma is a rare but treatable cause of hypertension in ADPKD; given the anatomical complexities these patients present, careful preoperative planning and surgical technique are essential to a favorable outcome
Estimates of the error in Gauss–Legendre quadrature for double integrals

AbstractError estimates are a very important aspect of numerical integration. It is desirable to know what level of truncation error might be expected for a given number of integration points. Here, we determine estimates for the truncation error when Gauss–Legendre quadrature is applied to the numerical evaluation of two dimensional integrals which arise in the boundary element method. Two examples are considered; one where the integrand contains poles, when its definition is extended into the complex plane, and another which contains branch points. In both cases we obtain error estimates which agree with the actual error to at least one significant digit
Measurement of the transverse momentum distribution of Z/γ⁎ bosons in proton–proton collisions at s=7 TeV with the ATLAS detector

AbstractA measurement of the Z/γ⁎ transverse momentum (pTZ) distribution in proton–proton collisions at s=7 TeV is presented using Z/γ⁎→e+e− and Z/γ⁎→μ+μ− decays collected with the ATLAS detector in data sets with integrated luminosities of 35 pb−1 and 40 pb−1, respectively. The normalized differential cross sections are measured separately for electron and muon decay channels as well as for their combination up to pTZ of 350 GeV for invariant dilepton masses 66 GeV<mℓℓ<116 GeV. The measurement is compared to predictions of perturbative QCD and various event generators. The prediction of resummed QCD combined with fixed order perturbative QCD is found to be in good agreement with the data
Search for events with large missing transverse momentum, jets, and at least two tau leptons in 7 TeV proton–proton collision data with the ATLAS detector

AbstractA search for events with large missing transverse momentum, jets, and at least two tau leptons has been performed using 2 fb−1 of proton–proton collision data at s=7 TeV recorded with the ATLAS detector at the Large Hadron Collider. No excess above the Standard Model background expectation is observed and a 95% CL upper limit on the visible cross section for new phenomena is set, where the visible cross section is defined by the product of cross section, branching fraction, detector acceptance and event selection efficiency. A 95% CL lower limit of 32 TeV is set on the gauge-mediated supersymmetry breaking (GMSB) scale Λ independent of tanβ. These limits provide the most stringent tests to date in a large part of the considered parameter space
Contribution of the intracellular C terminal domain to regulation of human P2X1 receptors for ATP by phorbol ester and Gq coupled mGlu1α receptors

AbstractP2X1 receptors are expressed in arteries and blood platelets, play an important role in the cardiovascular system, and their activity can be potentiated following stimulation of Gq coupled receptors or phorbol ester treatment. The contribution of the intracellular carboxy terminus of the P2X1 receptor to this regulation was determined using over-expression of the C terminus and a mutagenesis based approach on recombinant receptors expressed in Xenopus oocytes. PMA induced potentiation of P2X1 receptor currents (~125% above control) was abolished following over-expression of the intracellular carboxy terminus of the P2X1 receptor. To determine the molecular basis of regulation by the carboxy terminus a series of individual cysteine point mutations between His355 and Tyr370 was characterized. PMA potentiation was abolished for the P2X1 receptor mutants H355C, P358C, Y363C, K367C, F368C, K369C and Y370C. When these mutations were introduced into the carboxy terminus fragment the inhibitory effect was absent only for P358C, K367C and Y370C mutants. These results suggest that residues Pro358, Lys367 and Tyr370 are involved in the sequestering effect of the carboxy terminal fragment and indicate they are directly involved in modulation of the receptor by binding to a regulatory factor. The other mutants that abolished the PMA effect when introduced into the P2X1 receptor are likely to be involved in transduction of the regulatory event. These studies highlight the importance of the carboxy terminus in determining the properties and regulation of the P2X1 receptor and suggest that the intracellular terminal regions of the receptor close to the transmembrane segments interact
Drug-resistant tuberculosis: time for visionary political leadership

SummaryTwo decades ago, WHO declared tuberculosis a global emergency, and invested in the highly cost-effective directly observed treatment short-course programme to control the epidemic. At that time, most strains of Mycobacterium tuberculosis were susceptible to first-line tuberculosis drugs, and drug resistance was not a major issue. However, in 2013, tuberculosis remains a major public health concern worldwide, with prevalence of multidrug-resistant (MDR) tuberculosis rising. WHO estimates roughly 630 000 cases of MDR tuberculosis worldwide, with great variation in the frequency of MDR tuberculosis between countries. In the past 8 years, extensively drug-resistant (XDR) tuberculosis has emerged, and has been reported in 84 countries, heralding the possibility of virtually untreatable tuberculosis. Increased population movement, the continuing HIV pandemic, and the rise in MDR tuberculosis pose formidable challenges to the global control of tuberculosis. We provide an overview of the global burden of drug-resistant disease; discuss the social, health service, management, and control issues that fuel and sustain the epidemic; and suggest specific recommendations for important next steps. Visionary political leadership is needed to curb the rise of MDR and XDR tuberculosis worldwide, through sustained funding and the implementation of global and regional action plans
Construction and classification of novel BPS Wilson loops in quiver Chern–Simons-matter theories

AbstractIn this paper we construct and classify novel Drukker–Trancanelli (DT) type BPS Wilson loops along infinite straight lines and circles in N=2,3 quiver superconformal Chern–Simons-matter theories, Aharony–Bergman–Jafferis–Maldacena (ABJM) theory, and N=4 orbifold ABJM theory. Generally we have four classes of Wilson loops, and all of them preserve the same supersymmetries as the BPS Gaiotto–Yin (GY) type Wilson loops. There are several free complex parameters in the DT type BPS Wilson loops, and for two classes of Wilson loops in ABJM theory and N=4 orbifold ABJM theory there are supersymmetry enhancements at special values of the parameters. We check that the differences of the DT type and GY type Wilson loops are Q-exact with Q being some supercharges preserved by both the DT type and GY type Wilson loops. The results would be useful to calculate vacuum expectation values of the DT type Wilson loops in matrix models if they are still BPS quantum mechanically
A numerical algorithm for zero counting, I: Complexity and accuracy

AbstractWe describe an algorithm to count the number of distinct real zeros of a polynomial (square) system f. The algorithm performs O(log(nDκ(f))) iterations (grid refinements) where n is the number of polynomials (as well as the dimension of the ambient space), D is a bound on the polynomials’ degree, and κ(f) is a condition number for the system. Each iteration uses an exponential number of operations. The algorithm uses finite-precision arithmetic and a major feature of our results is a bound for the precision required to ensure that the returned output is correct which is polynomial in n and D and logarithmic in κ(f). The algorithm parallelizes well in the sense that each iteration can be computed in parallel polynomial time in n, logD and log(κ(f))
Randomized Trial of Complete Versus Lesion-Only Revascularization in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI and Multivessel Disease The CvLPRIT Trial

AbstractBackgroundThe optimal management of patients found to have multivessel disease while undergoing primary percutaneous coronary intervention (P-PCI) for ST-segment elevation myocardial infarction is uncertain.ObjectivesCvLPRIT (Complete versus Lesion-only Primary PCI trial) is a U.K. open-label randomized study comparing complete revascularization at index admission with treatment of the infarct-related artery (IRA) only.MethodsAfter they provided verbal assent and underwent coronary angiography, 296 patients in 7 U.K. centers were randomized through an interactive voice-response program to either in-hospital complete revascularization (n = 150) or IRA-only revascularization (n = 146). Complete revascularization was performed either at the time of P-PCI or before hospital discharge. Randomization was stratified by infarct location (anterior/nonanterior) and symptom onset (≤3 h or >3 h). The primary endpoint was a composite of all-cause death, recurrent myocardial infarction (MI), heart failure, and ischemia-driven revascularization within 12 months.ResultsPatient groups were well matched for baseline clinical characteristics. The primary endpoint occurred in 10.0% of the complete revascularization group versus 21.2% in the IRA-only revascularization group (hazard ratio: 0.45; 95% confidence interval: 0.24 to 0.84; p = 0.009). A trend toward benefit was seen early after complete revascularization (p = 0.055 at 30 days). Although there was no significant reduction in death or MI, a nonsignificant reduction in all primary endpoint components was seen. There was no reduction in ischemic burden on myocardial perfusion scintigraphy or in the safety endpoints of major bleeding, contrast-induced nephropathy, or stroke between the groups.ConclusionsIn patients presenting for P-PCI with multivessel disease, index admission complete revascularization significantly lowered the rate of the composite primary endpoint at 12 months compared with treating only the IRA. In such patients, inpatient total revascularization may be considered, but larger clinical trials are required to confirm this result and specifically address whether this strategy is associated with improved survival. (Complete Versus Lesion-only Primary PCI Pilot Study [CvLPRIT]; ISRCTN70913605
Probing MeV to 90 GeV axion-like particles with LEP and LHC

AbstractAxion-like particles (ALPs), relatively light (pseudo-)scalars coupled to two gauge bosons, are a common feature of many extensions of the Standard Model. Up to now there has been a gap in the sensitivity to such particles in the MeV to 10 GeV range. In this note we show that LEP data on Z→γγ decays provides significant constraints in this range (and indeed up to the Z-mass). We also discuss the sensitivities of LHC and future colliders. Particularly the LHC shows promising sensitivity in searching for a pseudo-scalar with 4≲ma≲60 GeV in the channel pp→3γ with m3γ≈mZ
Spin-chain with PSU(2|2)⊗U(1)3 and non-linear σ-model with D(2,1;γ)

AbstractWe propose that the spin-chain with the PSU(2|2)⊗U(1)3 symmetry is equivalent to the non-linear σ-model on PSU(2|2)⊗U(1)3/{H⊗U(1)} with a certain subgroup H. To this end we show that the spin-variable of the former theory is identified as the Killing scalar of the latter and their correlation functions can have the same integrability. It is crucial to think that the respective theory gets the PSU(2|2)⊗U(1)3 symmetry by a symmetry reduction of the exceptional supergroup D(2,1;γ), rather than by an extension of PSU(2|2)
Forward-central two-particle correlations in p–Pb collisions at sNN=5.02 TeV

AbstractTwo-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5<|η|<4.0) and associated particles in the central range (|η|<1.0) are measured with the ALICE detector in p–Pb collisions at a nucleon–nucleon centre-of-mass energy of 5.02 TeV. The trigger particles are reconstructed using the muon spectrometer, and the associated particles by the central barrel tracking detectors. In high-multiplicity events, the double-ridge structure, previously discovered in two-particle angular correlations at midrapidity, is found to persist to the pseudorapidity ranges studied in this Letter. The second-order Fourier coefficients for muons in high-multiplicity events are extracted after jet-like correlations from low-multiplicity events have been subtracted. The coefficients are found to have a similar transverse momentum (pT) dependence in p-going (p–Pb) and Pb-going (Pb–p) configurations, with the Pb-going coefficients larger by about 16±6%, rather independent of pT within the uncertainties of the measurement. The data are compared with calculations using the AMPT model, which predicts a different pT and η dependence than observed in the data. The results are sensitive to the parent particle v2 and composition of reconstructed muon tracks, where the contribution from heavy flavour decays is expected to dominate at pT>2 GeV/c
Progestogen-only contraceptive use among breastfeeding women : a systematic review

Background: Postpartum women need effective contraception. Concerns have been raised that use of progestogen-only contraceptives (POCs) may affect breastfeeding performance and infant health outcomes. 
Objectives: We investigated the clinical outcomes of breastfeeding duration, initiation of supplemental feeding and weaning, as well as infant outcomes including infant growth, health and development among breastfeeding women using POCs compared with breastfeeding women not using POCs. 
Search strategy: We searched the PubMed database for all articles published from database inception through December 2014. 
Selection criteria: We included primary research studies of breastfeeding women of any age or parity who received POCs, including progestogen-only pills, injectables, implants or hormonal intrauterine devices (IUDs). The main outcomes were breastfeeding performance (as measured by initiation, continuation, frequency and exclusivity of breastfeeding) and infant health (as measured by growth, development or adverse health effects). 
Results: Forty-nine articles reporting on 47 different studies were identified that investigated the use of POCs in breastfeeding women and reported clinically relevant outcomes of infant growth, health or breastfeeding performance. Studies ranged from poor to fair methodological quality and generally failed to show negative effects of the use of POCs on breastfeeding outcomes or on infant growth or development. One randomized controlled trial (RCT) raises concerns that immediate insertion of the levonorgestrel IUD postpartum may be associated with poorer breastfeeding performance when compared with delayed insertion, although two other RCTs evaluating early etonogestrel implants compared with delayed initiation of implants or depot medroxyprogesterone acetate failed to find such an association. 
Conclusion: The preponderance of evidence fails to demonstrate adverse breastfeeding outcomes or negative health outcomes in infants such as restricted growth, health problems or impaired development. Evidence newly added to this review was largely consistent with previous evidence
Measurements of jet charge with dijet events in pp collisions at sqrt(s)
  = 8 TeV

Jet charge is an estimator of the electric charge of a quark, antiquark, or
gluon initiating a jet. It is based on the momentum-weighted sum of the
electric charges of the jet constituents. Measurements of three charge
observables of the leading jet in transverse momentum pT are performed with
dijet events. The analysis is carried out with data collected by the CMS
experiment at the CERN LHC in proton-proton collisions at sqrt(s) = 8 TeV
corresponding to an integrated luminosity of 19.7 inverse femtobarns. The
results are presented as a function of the pT of the leading jet and compared
to predictions from leading- and next-to-leading-order event generators
combined with parton showers. Measured jet charge distributions, unfolded for
detector effects, are reported, which expand on previous measurements of the
jet charge average and standard deviation in pp collisions.Comment: Replaced with the published version. Added the journal reference and
  DOI. All the figures and tables can be found at
  http://cms-results.web.cern.ch/cms-results/public-results/publications/SMP-15-003
  (CMS public pages
Black Hole Thermodynamics with Dynamical Lambda

We study evolution and thermodynamics of a slow-roll transition between early
and late time de Sitter phases, both in the homogeneous case and in the
presence of a black hole, in a scalar field model with a generic potential
having both a maximum and a positive minimum. Asymptotically future de Sitter
spacetimes are characterized by ADM charges known as cosmological tensions. We
show that the late time de Sitter phase has finite cosmological tension when
the scalar field oscillation around its minimum is underdamped, while the
cosmological tension in the overdamped case diverges. We compute the variation
in the cosmological and black hole horizon areas between the early and late
time phases, finding that the fractional change in horizon area is proportional
to the corresponding fractional change in the effective cosmological constant.
We show that the extended first law of thermodynamics, including variation in
the effective cosmological constant, is satisfied between the initial and final
states, and discuss the dynamical evolution of the black hole temperature.Comment: 34 pages, 3 figure
Declarative Sequential Pattern Mining of Care Pathways

Sequential pattern mining algorithms are widely used to explore care pathways
database, but they generate a deluge of patterns, mostly redundant or useless.
Clinicians need tools to express complex mining queries in order to generate
less but more significant patterns. These algorithms are not versatile enough
to answer complex clinician queries. This article proposes to apply a
declarative pattern mining approach based on Answer Set Programming paradigm.
It is exemplified by a pharmaco-epidemiological study investigating the
possible association between hospitalization for seizure and antiepileptic drug
switch from a french medico-administrative database
Kaon Mixing Beyond the SM from Nf=2 tmQCD and model independent
  constraints from the UTA

We present the first unquenched, continuum limit, lattice QCD results for the
matrix elements of the operators describing neutral kaon oscillations in
extensions of the Standard Model. Owing to the accuracy of our calculation on
\Delta S=2 weak Hamiltonian matrix elements, we are able to provide a refined
Unitarity Triangle analysis improving the bounds coming from model independent
constraints on New Physics. In our non-perturbative computation we use a
combination of Nf=2 maximally twisted sea quarks and Osterwalder-Seiler valence
quarks in order to achieve both O(a)-improvement and continuum-like
renormalization properties for the relevant four-fermion operators. The
calculation of the renormalization constants has been performed
non-perturbatively in the RI-MOM scheme. Based on simulations at four values of
the lattice spacing and a number of quark masses we have
extrapolated/interpolated our results to the continuum limit and physical
light/strange quark masses.Comment: small corrections to RC matrix Z_Q for i,j=2,3; marginal corrections
  to bag parameters B_4, B_5, and ratios R_4, R_5; results on NP scales from
  UTfit analysis unchanged; 66 pages, 12 figure