pinecone/core-2020-05-10-deduplication huggingface dataset:
MEASUREMENTS OF STELLAR INCLINATIONS FOR KEPLER PLANET CANDIDATES. II. CANDIDATE SPIN-ORBIT MISALIGNMENTS IN SINGLE- AND MULTIPLE-TRANSITING SYSTEMS

We present a test for spin-orbit alignment for the host stars of 25 candidate planetary systems detected by the Kepler spacecraft. The inclination angle of each star's rotation axis was estimated from its rotation period, rotational line broadening, and radius. The rotation periods were determined using the Kepler photometric time series. The rotational line broadening was determined from high-resolution optical spectra with the Subaru High Dispersion Spectrograph. Those same spectra were used to determine the star's photospheric parameters (effective temperature, surface gravity, metallicity), which were then interpreted with stellar-evolutionary models to determine stellar radii. We combine the new sample with the seven stars from our previous work on this subject, finding that the stars show a statistical tendency to have inclinations near 90°, in alignment with the planetary orbits. Possible spin-orbit misalignments are seen in several systems, including three multiple-planet systems (KOI-304, 988, 2261). Ideally, these systems should be scrutinized with complementary techniques, such as the Rossiter-McLaughlin effect, starspot-crossing anomalies, or asteroseismology, but the measurements will be difficult owing to the relatively faint apparent magnitudes and small transit signals in these systems.United States. National Aeronautics and Space Administration (Origins program NNX11AG85G)Kepler Participating Scientist Program (NNX12AC76G
Searches for a heavy scalar boson H decaying to a pair of 125 GeV Higgs bosons hh or for a heavy pseudoscalar boson A decaying to Zh, in the final states with h → ττ

A search for a heavy scalar boson H decaying into a pair of lighter standard-model- like 125 GeV Higgs bosons h and a search for a heavy pseudoscalar boson A decaying into a Z and an h boson are presented. The searches are performed on a dataset corresponding to an integrated luminosity of 19.7 fb$^{−1}$ of pp collision data at a centre- of-mass energy of 8 TeV, collected by CMS in 2012. A final state consisting of two τ leptons and two b jets is used to search for the H → hh decay. A final state consisting of two τ leptons from the h boson decay, and two additional leptons from the Z boson decay, is used to search for the decay A → Zh. The results are interpreted in the context of two-Higgs-doublet models. No excess is found above the standard model expectation and upper limits are set on the heavy boson production cross sections in themassranges260<mH <350GeVand220<mA <350GeV
Factorization for the light-jet mass and hemisphere soft function

Many collider observables suffer from non-global logarithms not captured by standard resummation techniques. Classic examples are the light-jet mass event shape in the limit of small mass and the related hemisphere soft function. We derive factorization formulas for both of these and explicitly demonstrate that they capture all logarithms present at NNLO. These formulas achieve full scale separation and provide the basis for all-order resummations. A characteristic feature of non-global observables is that the soft radiation is driven by multi-Wilson-line operators, and the ones arising here map onto those relevant for the case of narrow-cone jet cross sections. Numerically, the contributions of non-global logarithms to resummed hemisphere-mass event shapes are sizeable
New nurses burnout and workplace wellbeing: The influence of authentic leadership and psychological capital

AbstractThe detrimental effects of burnout on nurses’ health and wellbeing are well documented and positive leadership has been shown to be an important organizational resource for discouraging the development of burnout. Intrapersonal resources also play a protective role against workplace stressors. This study investigated the influence of authentic leadership, an organizational resource, and psychological capital, an intrapersonal resource, on new graduate burnout, occupational satisfaction, and workplace mental health over the first year of employment (n=205). Results supported the protective role of organizational and intrapersonal resources against burnout, job dissatisfaction, and mental health
Kinetics of Conformational Changes of the FKF1-LOV Domain upon Photoexcitation

AbstractThe photochemical reaction dynamics of a light-oxygen-voltage (LOV) domain from the blue light sensor protein, FKF1 (flavin-binding Kelch repeat F-box) was studied by means of the pulsed laser-induced transient grating method. The observed absorption spectral changes upon photoexcitation were similar to the spectral changes observed for typical LOV domain proteins (e.g., phototropins). The adduct formation took place with a time constant of 6 μs. After this reaction, a significant conformational change with a time constant of 6 ms was observed as a change in the diffusion coefficient. An FKF1-LOV mutant without the conserved loop connecting helices E and F, which is present only in the FKF1/LOV Kelch protein 2/ZEITLUPE family, did not show these slow phase dynamics. This result indicates that the conformational change in the loop region represents a major change in the FKF1-LOV photoreaction
Relativistic corrections to the pair Bc-meson production in e+e− annihilation

AbstractRelativistic corrections to the pair Bc-meson production in e+e−-annihilation are calculated. We investigate a production of pair pseudoscalar, vector and pseudoscalar+vector Bc-mesons in the leading order perturbative quantum chromodynamics and relativistic quark model. Relativistic expressions of the pair production cross sections are obtained. Their numerical evaluation shows that relativistic effects in the production amplitudes and bound state wave functions three times reduce nonrelativistic results at the center-of-mass energy s=22 GeV
The lifetime earnings premium in the public sector: The view from Europe

AbstractIn a context of widespread concern about budget deficits, it is important to assess whether public sector pay is in line with the private sector. Our paper proposes an estimation of differences in lifetime values of employment between public and private sectors for five European countries. We use data from the European Community Household Panel over the period 1994–2001 for Germany, the Netherlands, France, Italy and Spain. We look at lifetime values instead of wage levels because, as we show in our results, differences in earnings mobility, earnings volatility and job loss risk across sectors occur in many instances and these will matter to forward-looking individuals. When aggregated into a measure of lifetime value of employment in either sector, these differences yield estimates of the lifetime premium in the public sector for these five countries. We also present differences in the institutional and labour market structures in these countries and find that countries for which we estimate a positive lifetime premium in the public sector, i.e. France and Spain, are also the countries where access to the public sector requires costly entry procedures. This paper is to the best of our knowledge the first to use this dynamic approach applied to Europe, which we are able to do with a common dataset, time-period and model
Probing compositeness with the CMS eejj & eej data

AbstractQuark-lepton compositeness is a well-known beyond the Standard Model (SM) scenario with heavy exotic particles like leptoquarks (LQs) and leptogluons (LGs) etc. These particles can couple to leptons and jets simultaneously. In this letter, we use the recent CMS scalar LQ search data in the eejj and eej channels to probe this scenario. We recast the data in terms of a color octet partner of the SM electron (or a first generation spin-1/2 LG) that couples to an electron and a gluon via a dimension five operator suppressed by the quark–lepton compositeness scale (Λ). By combining different production processes of the color octet electron (e8) at the LHC, we use the CMS 8 TeV data to obtain a simultaneous bound on Λ and the mass of the e8 (Me8). We also study the reach of the 13 TeV LHC to discover the e8 and interpret the required luminosity in terms of Me8 and Λ
The Number of Genomic Copies at the 16p11.2 Locus Modulates Language, Verbal Memory, and Inhibition

AbstractBackgroundDeletions and duplications of the 16p11.2 BP4-BP5 locus are prevalent copy number variations (CNVs), highly associated with autism spectrum disorder and schizophrenia. Beyond language and global cognition, neuropsychological assessments of these two CNVs have not yet been reported.MethodsThis study investigates the relationship between the number of genomic copies at the 16p11.2 locus and cognitive domains assessed in 62 deletion carriers, 44 duplication carriers, and 71 intrafamilial control subjects.ResultsIQ is decreased in deletion and duplication carriers, but we demonstrate contrasting cognitive profiles in these reciprocal CNVs. Deletion carriers present with severe impairments of phonology and of inhibition skills beyond what is expected for their IQ level. In contrast, for verbal memory and phonology, the data may suggest that duplication carriers outperform intrafamilial control subjects with the same IQ level. This finding is reminiscent of special isolated skills as well as contrasting language performance observed in autism spectrum disorder. Some domains, such as visuospatial and working memory, are unaffected by the 16p11.2 locus beyond the effect of decreased IQ. Neuroimaging analyses reveal that measures of inhibition covary with neuroanatomic structures previously identified as sensitive to 16p11.2 CNVs.ConclusionsThe simultaneous study of reciprocal CNVs suggests that the 16p11.2 genomic locus modulates specific cognitive skills according to the number of genomic copies. Further research is warranted to replicate these findings and elucidate the molecular mechanisms modulating these cognitive performances
Studying the perturbed Wess–Zumino–Novikov–Witten SU(2)k theory using the truncated conformal spectrum approach

AbstractWe study the SU(2)k Wess–Zumino–Novikov–Witten (WZNW) theory perturbed by the trace of the primary field in the adjoint representation, a theory governing the low-energy behavior of a class of strongly correlated electronic systems. While the model is non-integrable, its dynamics can be investigated using the numerical technique of the truncated conformal spectrum approach combined with numerical and analytical renormalization groups (TCSA+RG). The numerical results so obtained provide support for a semiclassical analysis valid at k≫1. Namely, we find that the low energy behavior is sensitive to the sign of the coupling constant, λ. Moreover, for λ>0 this behavior depends on whether k is even or odd. With k even, we find definitive evidence that the model at low energies is equivalent to the massive O(3) sigma model. For k odd, the numerical evidence is more equivocal, but we find indications that the low energy effective theory is critical
An application of transverse momentum dependent evolution equations in QCD

AbstractThe properties and behaviour of the solutions of the recently obtained kt-dependent QCD evolution equations are investigated. When used to reproduce transverse momentum spectra of hadrons in Semi-Inclusive DIS, an encouraging agreement with data is found. The present analysis also supports at the phenomenological level the factorization properties of the Semi-Inclusive DIS cross-sections in terms of kt-dependent distributions. Further improvements and possible developments of the proposed evolution equations are envisaged
Differential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues

AbstractAromatic tuning, i.e. repositioning aromatic residues found at the cytoplasmic end of transmembrane (TM) domains within bacterial receptors, has been previously shown to modulate signal output from the aspartate chemoreceptor (Tar) and the major osmosensor EnvZ of Escherichia coli. In the case of Tar, changes in signal output consistent with the vertical position of the native Trp-Tyr aromatic tandem within TM2 were observed. In contrast, within EnvZ, where a Trp-Leu-Phe aromatic triplet was repositioned, the surface that the triplet resided upon was the major determinant governing signal output. However, these studies failed to determine whether moving the aromatic residues was sufficient to physically reposition the TM helix within a membrane. Recent coarse-grained molecular dynamics (CG-MD) simulations predicted displacement of Tar TM2 upon moving the aromatic residues at the cytoplasmic end of the helix. Here, we demonstrate that repositioning the Trp-Tyr tandem within Tar TM2 displaces the C-terminal boundary of the helix relative to the membrane. In a similar analysis of EnvZ, an abrupt initial displacement of TM2 was observed but no subsequent movement was seen, suggesting that the vertical position of TM2 is not governed by the location of the Trp-Leu-Phe triplet. Our results also provide another set of experimental data, i.e. the resistance of EnvZ TM2 to being displaced upon aromatic tuning, which could be useful for subsequent refinement of the initial CG-MD simulations. Finally, we discuss the limitations of these methodologies, how moving flanking aromatic residues might impact steady-state signal output and the potential to employ aromatic tuning in other bacterial membrane-spanning receptors
Current concept of reverse cholesterol transport and novel strategy for atheroprotection

AbstractElevated levels of low-density lipoprotein cholesterol (LDL-C) increase the risk of coronary heart disease (CHD), but pharmacologic therapy to decrease LDL-C significantly reduces the risk of cardiovascular events. Despite the effectiveness of statin therapy, there remains significant residual cardiovascular risk. A low plasma concentration of high-density lipoprotein cholesterol (HDL-C) is associated with increased risk of CHD. Moreover, recent studies have shown that HDL-C levels during statin treatment remain an independent predictor of the risk of cardiovascular events. However, recent clinical trials aimed at reducing CHD risk by raising HDL-C levels have not shown satisfactory results and it is becoming evident that a functional HDL-C is a more desirable target than simply elevating its level. This review summarizes the function of HDL-C in reverse cholesterol transfer from peripheral tissue and discusses the latest HDL-targeting therapeutic strategies including the manipulation of microRNAs
Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

SummaryMature dendritic cells (DCs) are established as unrivaled antigen-presenting cells (APCs) in the initiation of immune responses, whereas steady-state DCs induce peripheral T cell tolerance. Using various genetic approaches, we depleted CD11c+ DCs in mice and induced autoimmune CNS inflammation. Unexpectedly, mice lacking DCs developed aggravated disease compared to control mice. Furthermore, when we engineered DCs to present a CNS-associated autoantigen in an induced manner, we found robust tolerance that prevented disease, which coincided with an upregulation of the PD-1 receptor on antigen-specific T cells. Additionally, we showed that PD-1 was necessary for DC-mediated induction of regulatory T cells. Our results show that a reduction of DCs interferes with tolerance, resulting in a stronger inflammatory response, and that other APC populations could compensate for the loss of immunogenic APC function in DC-depleted mice
Weinberg–Salam model at finite temperature and density

AbstractWe present a new gauge fixing condition for the Weinberg–Salam electro-weak theory at finite temperature and density. After spontaneous symmetry breaking occurs, every unphysical term in the Lagrangian is eliminated with our gauge fixing condition. A new and simple Lagrangian can be obtained where we can identify the propagators and vertices. Some consequences are discussed, as the new gauge-dependent masses of the gauge fields and the new Faddeev–Popov Lagrangian. After obtaining the quadratic terms, we calculate exactly the 1-loop effective potential identifying the contribution of every particular field
Measurement of the production cross section for a W boson and two b jets in pp collisions at s=7 TeV

AbstractThe production cross section for a W boson and two b jets is measured using proton–proton collisions at s=7 TeV in a data sample collected with the CMS experiment at the LHC corresponding to an integrated luminosity of 5.0 fb−1. The W+bb¯ events are selected in the W→μν decay mode by requiring a muon with transverse momentum pT>25 GeV and pseudorapidity |η|<2.1, and exactly two b-tagged jets with pT>25 GeV and |η|<2.4. The measured W+bb¯ production cross section in the fiducial region, calculated at the level of final-state particles, is σ(pp→W+bb¯)×B(W→μν)=0.53±0.05(stat.)±0.09(syst.)±0.06(theo.)±0.01(lum.) pb, in agreement with the standard model prediction. In addition, kinematic distributions of the W+bb¯ system are in agreement with the predictions of a simulation using MadGraph and pythia
On a Poisson–Lie deformation of the BCn Sutherland system

AbstractA deformation of the classical trigonometric BCn Sutherland system is derived via Hamiltonian reduction of the Heisenberg double of SU(2n). We apply a natural Poisson–Lie analogue of the Kazhdan–Kostant–Sternberg type reduction of the free particle on SU(2n) that leads to the BCn Sutherland system. We prove that this yields a Liouville integrable Hamiltonian system and construct a globally valid model of the smooth reduced phase space wherein the commuting flows are complete. We point out that the reduced system, which contains 3 independent coupling constants besides the deformation parameter, can be recovered (at least on a dense submanifold) as a singular limit of the standard 5-coupling deformation due to van Diejen. Our findings complement and further develop those obtained recently by Marshall on the hyperbolic case by reduction of the Heisenberg double of SU(n,n)
Search for contact interactions in dilepton events from pp collisions at s=7 TeV with the ATLAS detector

AbstractThis Letter presents a search for contact interactions in the dielectron and dimuon channels using data from proton–proton collisions produced by the LHC at s=7 TeV and recorded by the ATLAS detector. The data sample, collected in 2011, corresponds to an integrated luminosity of 1.08 and 1.21 fb−1 in the e+e− and μ+μ− channels, respectively. No significant deviations from the standard model are observed. Using a Bayesian approach with a prior flat in 1/Λ2, the following 95% CL lower limits are placed on the energy scale of ℓℓqq contact interactions: Λ−>10.1 TeV (Λ+>9.4 TeV) in the electron channel and Λ−>8.0 TeV (Λ+>7.0 TeV) in the muon channel for constructive (destructive) interference in the left–left isoscalar contact interaction model. Limits are also provided for a prior flat in 1/Λ4
The effect of delay in collection and processing on RNA integrity in human placenta: Experiences from rural Africa

AbstractThis paper examines the relationship between time to processing and RNA quality in placentas collected from women in a field setting in rural Gambia. Placental samples were collected from the villages and transferred to the laboratory. RNA was extracted using Trizol and integrity assessed using the RNA integrity number (RIN). Values were inversely correlated with delay in processing. Expression levels of candidate genes increased with decreasing RIN. Normalising to a housekeeper gene removed this artefact. We propose a cut-off point of 90 min from delivery, after which samples cannot be used for gene expression analysis
Symplectic critical models in 6+ϵ dimensions

AbstractWe consider nontrivial critical models in d=6+ϵ spacetime dimensions with anticommuting scalars transforming under the symplectic group Sp(N). These models are nonunitary, but the couplings are real and all operator dimensions are positive. At large N we can take ϵ→1 consistently with the loop expansion and thus provide evidence that these theories may be used to define critical models in d=7. The relation of these theories to critical Sp(N) theories, defined similarly to the well-known critical O(N) theories, is examined, and some similarities are pointed out
The Notch Delta-4 ligand helps to maintain the quiescence and the short-term reconstitutive potential of haematopoietic progenitor cells through activation of a key gene network

AbstractUnderstanding the role of Notch and its ligands within the different bone marrow niches could shed light on the mechanisms regulating haematopoietic progenitor cells (HPCs) maintenance and self-renewal. Here, we report that murine bone marrow HPCs activation by the vascular Notch Delta-4 ligand maintains a significant proportion of cells specifically in the G0 state. Furthermore, Delta-4/Notch pathway limits significantly the loss of the in vivo short-term reconstitutive potential upon transplantation of Delta-4 activated HPCs into lethally irradiated recipient mice. Both effects are directly correlated with the decrease of cell cycle genes transcription such as CYCLIN-D1, -D2, and -D3, and the upregulation of stemness related genes transcription such as BMI1, GATA2, HOXB4 and C-MYC. In addition, the transcriptional screening also highlights new downstream post-transcriptional factors, named PUMILIO1 and -2, as part of the stem signature associated with the Delta-4/Notch signalling pathway
Brasiliensin: A novel intestinal thrombin inhibitor from Triatoma brasiliensis (Hemiptera: Reduviidae) with an important role in blood intake

AbstractEvery hematophagous invertebrate studied to date produces at least one inhibitor of coagulation. Among these, thrombin inhibitors have most frequently been isolated. In order to study the thrombin inhibitor from Triatoma brasiliensis and its biological significance for the bug, we sequenced the corresponding gene and evaluated its biological function. The T. brasiliensis intestinal thrombin inhibitor, termed brasiliensin, was sequenced and primers were designed to synthesize double strand RNA (dsRNA). Gene knockdown (RNAi) was induced by two injections of 15μg of dsRNA into fourth instar nymphs. Forty-eight hours after the second injection, bugs from each group were allowed to feed on hamsters. PCR results showed that injections of dsRNA reduced brasiliensin expression in the anterior midgut by approximately 71% in knockdown nymphs when compared with controls. The reduction in gene expression was confirmed by the thrombin inhibitory activity assay and the citrated plasma coagulation time assay which showed activity reductions of ∼18- and ∼3.5-fold, respectively. Knockdown nymphs ingested approximately 39% less blood than controls. In order to confirm the importance of brasiliensin in blood ingestion, fourth instar nymphs were allowed to ingest feeding solution alone or feeding solution containing 15U of thrombin prior to blood feeding. Fifty-five percent less blood was ingested by nymphs which were fed thrombin prior to blood feeding. The results suggest that anticoagulant activity in the midgut is an important determinant of the amount of blood taken from the host. The role of anticoagulants during blood ingestion is discussed in the light of this novel insight