pinecone/core-2020-05-10-deduplication huggingface dataset:
The use of corsetry to treat Pott’s disease of the spine from 19th century Wolverhampton, England.

Corsets have been used both to create a fashionable silhouette and as an orthopaedic treatment for spinal conditions, but skeletal changes associated with the use of corsetry are rarely reported on in the palaeopathological literature. Here, we report on a 19th-century adult male with Pott’s disease of the vertebral column and related vertebral compression deformities. Wolverhampton HB40 presented destruction of the vertebral bodies of T6 to L4, ankylosis of the apophyseal joints of L1 and L2 and an angular kyphosis of the lumbar region, the result of tuberculosis. The presence of flattened spinous processes and bilateral acute angulation of multiple ribs in the lower thoracic region is indicative of plastic deformation caused by the use of the corset. The presence of both of these changes in an adult male, at a time when the use of cosmetic corsets by men was in decline, suggests that the compression trauma was the result of an orthopaedic corset used to correct the defective posture resulting from tubercular kyphosis, although corset use to obtain a fashionable silhouette cannot be ruled out
The influence of organisational climate on care of patients with schizophrenia: a qualitative analysis of health care professionals' views.

Background Organizational climate relates to how employees perceive and describe the characteristics of their employing organization. It has been found to have an impact on healthcare professionals' and patients' experiences of healthcare (e.g. job satisfaction, patient satisfaction), as well as organizational outcomes (e.g. employee productivity). This research used organizational theory to explore dynamics between health care professionals (pharmacists, doctors and nurses) in mental health outpatients' services for patients taking clozapine, and the perceived influence on patient care. Setting Seven clozapine clinics (from one NHS mental health Trust in the UK) which provided care for people with treatment resistant schizophrenia. Methods This study used qualitative methods to identify organizational climate factors such as deep structures, micro-climates and climates of conflict that might inhibit change and affect patient care. Using Interpretative Phenomenological Analysis, semistructured interviews were conducted with 10 healthcare professionals working in the clinics to explore their experiences of working in these clinics and the NHS mental health Trust the clinics were part of. Main outcome measure Health Care Professionals' perceptions of the care of patients with treatment resistant schizophrenia. Results Three superordinate themes emerged from the data: philosophy of care, need for change and role ambiguity. Participants found it difficult to articulate what a philosophy of care was and in spite of expressing the need for change in the way the clinics were run, could not see how 'changing things would work'. There was considerable role ambiguity with some 'blurring of the boundaries between roles'. Factors associated with organizational climate (role conflict; job satisfaction) were inhibiting team working and preventing staff from identifying the patients' health requirements and care delivery through innovation in skill mix. There were mixed attitudes towards the pharmacist's inclusion as a team member. Conclusions Our findings suggest deficiencies within the clinics that may be manifestations of the wider culture of the NHS. The implications for mental health outpatient clinics are that local initiatives are crucial to the implementation of recovery models; clear guidance should be provided on the skill mix required in clozapine clinics and interprofessional learning should be encouraged to reduce role conflict
Optimised conditions for the synthesis of 17O and 18O labelled cholesterol

Conditions are described for the preparation of cholesterol with 17O and 18O labels from i-cholesteryl methyl ether using minimal amounts of isotopically enriched water. Optimum yields employed trifluoromethanesulfonic acid as catalyst in 1,4-dioxane at room temperature with 5 equivalents of water. An isotopic enrichment >90% of that of the water used for the reaction could be attained. Tetrafluoroboric acid could also be used as catalyst, at the expense of a lower overall reaction yield. Byproducts from the reaction included dicholesteryl ether, methyl cholesteryl ether, compounds formed by ether hydrolysis, and olefins arising from elimination reactions. Reactions in tetrahydrofuran yielded significant amounts of cholesteryl ethers formed by reaction with alcohols arising from hydrolysis of the solvent
Development of a facial expression scale using footrot and mastitis as models of pain in sheep.

Management of pain in sheep is limited by the challenges of recognising and accurately quantifying pain in this species. The use of facial expression scoring to assess pain is a well-utilised, practical tool in both humans and non-human animals. The objective of this study was to develop a standardised facial expression pain scale for adult sheep, that could be used reliably and accurately to detect pain associated with naturally occurring painful diseases, such as footrot and mastitis. We also investigated whether the scale could be reliably and accurately utilised by observers after training, enabling the development of an on-farm pain assessment tool. The Sheep Pain Facial Expression Scale (SPFES) was able to correctly identify sheep suffering from disease with a high degree of accuracy (AUC; Footrot: 0.81, Mastitis: 0.80). Diseased sheep scored higher on the scale than controls on the day of disease identification (P<0.05) and diseased sheep showed changes in their facial expression after treatment (P<0.001). The abnormal facial expressions of diseased sheep reduced over time, and at recovery were in line with control sheep. Control sheep did not change their facial expression over time. Five scorers who were trained to use the developed scale also assessed the facial expressions of sheep. The scorers were blind to treatment and session. Scorers reliably (ICC: 0.86) and accurately (α = 0.86) identified changes in the facial expression of sheep with footrot over time (P<0.05), and scored control sheep consistently low over time. The SPFES offers a reliable and effective method of assessing pain in sheep after minimal training.We would like to thank the EU VII Framework Program (FP7-KBBE-2010-4) for funding this study as part of the AWIN project. Boehringer Imgelheim Ltd are thanked for providing the meloxicam used in this study.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.applanim.2016.01.00
Post-trafficking bordering practices : perverse co-production, marking and stretching borders

The research for this paper was funded by the Economic and Social Research Council – ESRC Res-062-23-1490: ‘Post Trafficking in Nepal: Sexuality and Citizenship in Livelihood Strategies’.This paper highlights the significance of post-trafficking scenarios for understanding bordering practices in political geography. In so doing, it addresses two significant research gaps: the lack of attention to trafficking in geography and the failure of wider interdisciplinary debates to engage with post-trafficking specifically. While extensive research in political geography has addressed the related experiences of refugees, asylum seekers and 'illegals', much of this work has centred on policies, processes and practices that aim to keep 'unwanted strangers out'. By contrast, very little research has addressed how the border is configured for and by those who are crossing-back over; those who are 'returning home', in this case from diverse trafficking situations. The paper draws on recent empirical research on post-trafficking citizenship and livelihoods in Nepal which examined how women returning from trafficking situations deal with stigma and marginalisation. Our analysis illuminates how bordering practices circumscribe and shape women's lives in powerful ways as they seek to (re)establish a sense of belonging and respect. We examine the interplay of state and non-state actors (national and transnational) in structuring mobility and anti-trafficking advocacy through a range of bordering practices and explore how the border is (co-)produced by varied actors at different border sites. This includes women returning from diverse trafficking situations, who invoke the border to argue that they are 'not as trafficked' as other women, and others who perform the border differently as agents for trafficking prevention.Publisher PDFPeer reviewe
Artificial turf field-A new build case study

This paper was presented at the 11th conference of the International Sports Engineering Association, ISEA 2016. This is an Open Access Article. It is published by Elsevier under the Creative Commons   Attribution-NonCommercial-NoDerivatives 4.0 license(CC BY-NC-ND). Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/4.0/© 2016 The Authors. Published by Elsevier Ltd. Artificial turf is widely used around the world and is used successfully for many sports and at many levels of performance requirement. Enhanced quality assurance systems set in place by sport governing bodies, such as World Rugby's Regulation 22 require inspection and certification of the installed system, and increasingly testing of the whole pitch build. Monitoring of play performance is then required at intervals to maintain certification for (high level) competition. However, very little published case study data exists that presents the build quality and monitoring data in a suitable form to share knowledge and best practice for the wide range of stakeholders, or for the maintenance provider. This paper presents a (unique) case study overview of the key activities undertaken and the measurement data and observations made during the construction of a full size elite level artificial (3rd generation) turf pitch, in autumn 2014 at Loughborough University. The research team monitored all the construction layers with a variety of specialist geotechnical devices, and additionally instrumented the pitch for drainage performance and thermal heat transfer. In addition play performance related properties and maintenance have been monitored during its first year of use. The test results give a unique insight into the surface system initial state and the early life changes that have occurred. The collective outcomes of the case study findings are considered useful to both academics and practitioners to further our understanding of appropriate methods of effective sports pitch monitoring for quality and performance and the expected early-life in service changes. The geotechnical measurements add to the current (global) debate on design verification and how to specify and monitor a pitch base build quality
Matching, Sorting, and Wages

We develop an empirical search-matching model which is suitable for analyzing the wage, employment and welfare impact of regulation in a labor market with heterogeneous workers and jobs. To achieve this we develop an equilibrium model of wage determination and employment which extends the current literature on equilibrium wage determination with matching and provides a bridge between some of the most prominent macro models and microeconometric research. The model incorporates productivity shocks, long-term contracts, on-the-job search and counter-offers. Importantly, the model allows for the possibility of assortative matching between workers and jobs due to complementarities between worker and job characteristics. We use the model to estimate the potential gain from optimal regulation and we consider the potential gains and redistributive impacts from optimal unemployment benefit policy. Here optimal policy is defined as that which maximizes total output and home production, accounting for the various constraints that arise from search frictions. The model is estimated on the NLSY using the method of moments
Socio-gnoseological Issues of Alienation in G.S. Batishchev's Works

AbstractIn this article, the authors have introduced the gynecological analyses of the category of alienation, the problem of self-knowledge and the ways of its scientific understanding in G.S. Batishchev's works. This time, the authors state that the problem of alienation of personality in modern world is connected with not only just deprivation of attention, but it is also the result of the increased alienation and social problems. The authors have analyzed a number of social relationships, such as social-organic, atomistic, each of which can be further divided into two more classes: utilitarian and pluralistic, polyphonic or harmonic. These classes of relationships are important for understanding of the subject and object, and their interrelations. A particular attention has been paid to social polyphonic ties, which facilitate the advancement of the individual and humanity towards the overcoming of alienation. In addition, the authors have focused their attention on the role of creative activities in the development of social relations. The analyses of relationships described in the works of G.S. Batishchev embark on the way of overcoming of alienation of personality
Homogenization of a stochastic nonlinear reaction–diffusion equation with a large reaction term: The almost periodic framework

AbstractHomogenization of a stochastic nonlinear reaction–diffusion equation with a large nonlinear term is considered. Under a general Besicovitch almost periodicity assumption on the coefficients of the equation we prove that the sequence of solutions of the said problem converges in probability towards the solution of a rather different type of equation, namely, the stochastic nonlinear convection–diffusion equation which we explicitly derive in terms of appropriate functionals. We study some particular cases such as the periodic framework, and many others. This is achieved under a suitable generalized concept of Σ-convergence for stochastic processes
Search for Dirac magnetic monopoles in e+e− collisions with the OPAL detector at LEP2

AbstractThis Letter describes a direct search for pair produced magnetic monopoles in e+e− collisions. The analysis is based on 62.7 pb−1 of data collected with the OPAL detector at an average centre-of-mass energy of s=206.3 GeV. The monopole signal was assumed to be characterized by two back-to-back particles with an anomalously high ionization energy loss dE/dx in the tracking chambers. No evidence for production of monopoles was observed. Upper limits were obtained on the magnetic monopole pair-production cross-section (σ) in the mass range 45 GeV/c2<mM<102 GeV/c2. The average limit is σ<0.05 pb and is essentially independent of the magnetic monopole mass. The cross-section limit is derived at the 95% confidence level and is valid for spin-1/2 magnetic monopoles
Clinical outcome 10 years after attempted percutaneous transluminal coronary angioplasty in 856 patients

AbstractObjectives.This study reports the 10-year outcome of 856 consecutive patients who underwent attempted coronary angioplasty at the Thoraxcenter during the years 1980 to 1985.Background.Coronary balloon angioplasty was first performed in 1977, and this procedure was introduced into clinical practice at the Thoraxcenter in 1980. Although advances have been made, extending our knowledge of the long-term outcome in terms of survival and major cardiac events remains of interest and a valuable guide in the treatment of patients with coronary artery disease.Methods.Details of survival, cardiac events, symptoms and medication were retrospectively obtained from the Dutch civil registry, medical records or by letter or telephone or from the patient's physician and entered into a dedicated data base. Patient survival curves were constructed, and factors influencing survival and cardiac events were identified.Results.The procedural clinical success rate was 82%. Follow-up information was obtained in 837 patients (97.8%). Six hundred forty-one patients (77%) were alive, of whom 334 (53%) were symptom free, and 254 (40%) were taking no antianginal medication. The overall 5- and 10-year survival rates were 90% (95% confidence interval [CI] 87.6% to 92.4%) and 78% (95% CI 75.0% to 81.0%), respectively, and the respective freedom from significant cardiac events (death, myocardial infarction, coronary artery bypass surgery and repeat angioplasty) was 57% (95% CI 53.4% to 60.6%) and 36% (95% CI 32.4% to 39.6%). Factors that were found to adversely influence 10-year survival were age ≥60 years (≥60 years [67%], 50 to 59 years [82%], <50 years [88%]), multivessel disease (multivessel disease [69%], single-vessel disease [82%]), impaired left ventricular function (ejection fraction <50% [57%], ≥50% [80%]) and a history of previous myocardial infarction (previous myocardial infarction [72%], no previous infarction [83%]). These factors were also found to be independent predictors of death during the follow-up period by a multivariate stepwise logistic regression analysis. Other factors tested, with no influence on survival, were gender, procedural success and stability of angina at the time of intervention.Conclusion.The long-term prognosis of patients after coronary angioplasty is good, particularly in those <60 years old with single-vessel disease and normal left ventricular function. The majority of patients are likely to experience a further cardiac event in the 10 years after their first angioplasty procedure
Non-Exercise Physical Activity and Survival English Longitudinal Study of Ageing

BackgroundThe activity patterns of older adults include more light/mild-intensity or “non-exercise” activity and less moderate- to vigorous-intensity activity. The health benefits of this type of activity pattern remain unclear.PurposeTo examine dose–response associations between physical activity and survival using time-varying analysis to understand the importance of “non-exercise” activity for survival in older adults.MethodsParticipants (N=10,426) were drawn from The English Longitudinal Study of Ageing, a representative sample of men and women aged ≥50 years living in England. Participant data were linked with death records from the National Health Service registries from 2002 to 2011. Analyses were conducted in 2013. Cox proportional hazards models were used to estimate the risk of death according to time-varying estimates of physical activity.ResultsOver an average follow-up of 7.8 years (median follow-up, 8.5 years), there were 1,896 deaths. In models adjusted for comorbidities, psychosocial factors, smoking, and obesity, there was a dose–response association between time-varying physical activity and mortality, with the greatest survival benefit in vigorously active participants. However, participating in mild (“non-exercise”)-intensity physical activity was also associated with a lower risk of all-cause mortality (hazard ratio [HR]=0.76, 95% CI=0.69, 0.83); cardiovascular mortality (HR=0.74, 95% CI=0.64, 0.85); and death by other causes (HR=0.67, 95% CI=0.58, 0.78). Time-varying models produced stronger, more robust estimates than models using a single measurement of physical activity at baseline.ConclusionsOlder adults gain health benefits from participating in regular “non-exercise” physical activity, although the greatest benefits are observed for more vigorous activity
Modifying the osteoblastic niche with zoledronic acid in vivo—Potential implications for breast cancer bone metastasis

AbstractIntroductionBone metastasis is the most common complication of advanced breast cancer. The associated cancer-induced bone disease is treated with bone-sparing agents like zoledronic acid. Clinical trials have shown that zoledronic acid also reduces breast cancer recurrence in bone; potentially by modifying the bone microenvironment surrounding disseminated tumour cells. We have characterised the early effects of zoledronic acid on key cell types of the metastatic niche in vivo, and investigated how these modify the location of breast tumour cells homing to bone.MethodsFemale mice were treated with a single, clinically achievable dose of zoledronic acid (100μg/kg) or PBS. Bone integrity, osteoclast and osteoblast activity and number/mm trabecular bone on 1, 3, 5 and 10days after treatment were assessed using μCT, ELISA (TRAP, PINP) and bone histomorphometry, respectively. The effect of zoledronic acid on osteoblasts was validated in genetically engineered mice with GFP-positive osteoblastic cells. The effects on growth plate cartilage were visualised by toluidine blue staining. For tumour studies, mice were injected i.c. with DID-labelled MDA-MB-231-NW1-luc2 breast cancer cells 5days after zoledronic acid treatment, followed by assessment of tumour cell homing to bone and soft tissues by multiphoton microscopy, flow cytometry and ex vivo cultures.ResultsAs early as 3days after treatment, animals receiving zoledronic acid had significantly increased trabecular bone volume vs. control. This rapid bone effect was reflected in a significant reduction in osteoclast and osteoblast number/mm trabecular bone and reduced bone marker serum levels (day 3–5). These results were confirmed in mice expressing GFP in osteoblastic linage cells. Pre-treatment with zoledronic acid caused accumulation of an extra-cellular matrix in the growth plate associated with a trend towards preferential [1] homing of tumour cells to osteoblast-rich areas of bone, but without affecting the total number of tumour cells. The number of circulating tumour cells was reduced in ZOL treated animals.ConclusionA single dose of zoledronic acid caused significant changes in the bone area suggested to contain the metastatic niche. Tumour cells arriving in this modified bone microenvironment appeared to preferentially locate to osteoblast-rich areas, supporting that osteoblasts may be key components of the bone metastasis niche and therefore a potential therapeutic target in breast cancer
The geometry of Minkowski spaces — A survey. Part I

AbstractWe survey elementary results in Minkowski spaces (i.e. finite dimensional Banach spaces) that deserve to be collected together, and give simple proofs for some of them. We place special emphasis on planar results. Many of these results have often been rediscovered as lemmas to other results. In Part I we cover the following topics: The triangle inequality and consequences such as the monotonicity lemma, geometric characterizations of strict convexity, normality (Birkhoff orthogonality), conjugate diameters and Radon curves, equilateral triangles and the affine regular hexagon construction, equilateral sets, circles: intersection, circumscribed, characterizations, circumference and area, inscribed equilateral polygons
Does the NJL chiral phase transition affect the elliptic flow of a fluid at fixed η/s?

AbstractWe have derived and solved numerically the Boltzmann–Vlasov transport equations that includes both two-body collisions and the chiral phase transition by mean of NJL-field dynamics. The scope is to understand if the field dynamics supply new genuine effects on the build-up of the elliptic flow v2, a measure of the asymmetry in the momentum space, and in particular if it can affect the relation between v2 and the shear viscosity to entropy ratio η/s. Solving the transport equation with a constant cross section for the condition of Au+Au collisions at sNN=200AGeV it is shown a sizable suppression of v2 due to the attractive nature of the field dynamics that generates the constituent mass. However the key result is that if η/s of the system is kept fixed by an appropriate local renormalization of the cross section the v2 does not depend on the details of the collisional and/or field dynamics and in particular it is not affected significantly by the chiral phase transition