pinecone/core-2020-05-10-deduplication huggingface dataset:
MineRank: Leveraging users’ latent roles for unsupervised collaborative information retrieval

International audienceResearch on collaborative information retrieval (CIR) has shown positive impacts of collaboration on retrieval effectiveness in the case of complex and/or exploratory tasks. The synergic effect of accomplishing something greater than the sum of its individual components is reached through the gathering of collaborators' complementary skills. However, these approaches often lack the consideration that collaborators might refine their skills and actions throughout the search session, and that a flexible system mediation guided by collaborators' behaviors should dynamically adapt to this situation in order to optimize search effectiveness. In this article, we propose a new unsupervised collaborative ranking algorithm which leverages collaborators' actions for (1) mining their latent roles in order to extract their complementary search behaviors; and (2) ranking documents with respect to the latent role of collaborators. Experiments using two user studies with respectively 25 and 10  pairs of collaborators demonstrate the benefit of such an unsupervised method driven by collaborators' behaviors throughout the search session. Also, a qualitative analysis of the identified latent role is proposed to explain an over-learning noticed in one of the datasets
Evaluating sealing efficiency of caprocks for CO2 storage: an overview of the Geocarbone Integrity program and results

8 pagesInternational audienceThe objectives of the Geocarbone-Integrity program are to develop techniques, methodologies and knowledge concerning the long term confinement of CO2 in geological storage. Linked to other French programs such as Geocarbone Injectivity or Picoref, it is an integrated approach involving geochemistry, petrophysics, geology and geomechanics. Different scales must be considered in order to describe caprocks: from the pore or grain scale in petrophysics and geochemistry, to regional scale in geology and geomechanics. The program focused on a specific site of the Paris basin but the methodologies developed are general and can be applied elsewhere
Diet affects the redox system in developing Atlantic cod(Gadus morhua) larvae

-The growth and development of marine fish larvae fed copepods is superior to those fed rotifers, but the underlying molecular reasons for this are unclear. In the following study we compared the effects of such diets on redox regulation pathways during development of Atlantic cod (Gadus morhua) larvae. Cod larvae were fed a control diet of copepods or the typical rotifer/Artemia diet commonly used in commercial marine fish hatcheries, from first feeding until after metamorphosis. The oxidised and reduced glutathione levels, the redox potential, and the mRNA expression of 100 genes in redox system pathways were then compared between treatments during larval development. We found that rotifer/Artemia-fed cod larvae had lower levels of oxidised glutathione, a more reduced redox potential, and altered expression of approximately half of the redox system genes when compared to copepod-fed larvae. This rotifer/Artemia diet-induced differential regulation of the redox system was greatest during periods of suboptimal growth. Upregulation of the oxidative stress response transcription factor, nrf2, and NRF2 target genes in rotifer/Artemia fed larvae suggest this diet induced an NRF2-mediated oxidative stress response. Overall, the data demonstrate that nutritional intake plays a role in regulating the redox system in developing fish larvae. This may be a factor in dietary-induced differences observed in larval growth
Submicroscopic Deletions at 13q32.1 Cause Congenital Microcoria.

International audienceCongenital microcoria (MCOR) is a rare autosomal-dominant disorder characterized by inability of the iris to dilate owing to absence of dilator pupillae muscle. So far, a dozen MCOR-affected families have been reported worldwide. By using whole-genome oligonucleotide array CGH, we have identified deletions at 13q32.1 segregating with MCOR in six families originating from France, Japan, and Mexico. Breakpoint sequence analyses showed nonrecurrent deletions in 5/6 families. The deletions varied from 35 kbp to 80 kbp in size, but invariably encompassed or interrupted only two genes: TGDS encoding the TDP-glucose 4,6-dehydratase and GPR180 encoding the G protein-coupled receptor 180, also known as intimal thickness-related receptor (ITR). Unlike TGDS which has no known function in muscle cells, GPR180 is involved in the regulation of smooth muscle cell growth. The identification of a null GPR180 mutation segregating over two generations with iridocorneal angle dysgenesis, which can be regarded as a MCOR endophenotype, is consistent with the view that deletions of this gene, with or without the loss of elements regulating the expression of neighboring genes, are the cause of MCOR
A new low magnetic field magnetar: the 2011 outburst of Swift
  J1822.3-1606

We report on the long term X-ray monitoring with Swift, RXTE, Suzaku, Chandra
and XMM-Newton of the outburst of the newly discovered magnetar Swift
J1822.3-1606 (SGR 1822-1606), from the first observations soon after the
detection of the short X-ray bursts which led to its discovery, through the
first stages of its outburst decay (covering the time-span from July 2011,
until end of April 2012). We also report on archival ROSAT observations which
witnessed the source during its likely quiescent state, and on upper limits on
Swift J1822.3-1606's radio-pulsed and optical emission during outburst, with
the Green Bank Telescope (GBT) and the Gran Telescopio Canarias (GTC),
respectively. Our X-ray timing analysis finds the source rotating with a period
of P=8.43772016(2) s and a period derivative \dot{P}=8.3(2)x10^{-14} s s^{-1} ,
which entails an inferred dipolar surface magnetic field of B~2.7x10^{13} G at
the equator. This measurement makes Swift J1822.3-1606 the second lowest
magnetic field magnetar (after SGR 0418+5729; Rea et al. 2010). Following the
flux and spectral evolution from the beginning of the outburst, we find that
the flux decreased by about an order of magnitude, with a subtle softening of
the spectrum, both typical of the outburst decay of magnetars. By modeling the
secular thermal evolution of Swift J1822.3-1606, we find that the observed
timing properties of the source, as well as its quiescent X-ray luminosity, can
be reproduced if it was born with a poloidal and crustal toroidal fields of
B_{p}~1.5x10^{14} G and B_{tor}~7x10^{14} G, respectively, and if its current
age is ~550 kyr.Comment: 14 pages, 9 figures; new observations added; ApJ in pres
A search for flavour changing neutral currents in top-quark decays in pp
  collision data collected with the ATLAS detector at sqrt(s) = 7 TeV

A search for flavour changing neutral current (FCNC) processes in top-quark
decays by the ATLAS Collaboration is presented. Data collected from pp
collisions at the LHC at a centre-of-mass energy of sqrt(s) = 7 TeV during
2011, corresponding to an integrated luminosity of 2.1 fb^-1, were used. A
search was performed for top-quark pair-production events, with one top quark
decaying through the t->Zq FCNC (q=u,c) channel, and the other through the
Standard Model dominant mode t->Wb. Only the decays of the Z boson to charged
leptons and leptonic W-boson decays were considered as signal. Consequently,
the final-state topology is characterised by the presence of three isolated
charged leptons, at least two jets and missing transverse momentum from the
undetected neutrino. No evidence for an FCNC signal was found. An upper limit
on the t->Zq branching ratio of BR(t->Zq)<0.73% is set at the 95% confidence
level.Comment: 19 pages plus author list (41 pages total), 2 figures, 3 tables,
  submitted to JHE
Infrared study of H 1743-322 in outburst: a radio-quiet and NIR-dim microquasar

International audienceContext. Microquasars are accreting Galactic sources that are commonly observed to launch relativistic jets. One of the most important issues regarding these sources is the energy budget of ejections relative to the accretion of matter.Aims. The X-ray binary, black hole candidate, and microquasar H 1743-322 exhibited a series of X-ray outbursts between 2003 and 2008. We took optical and near-infrared (OIR) observations with the ESO/NTT telescope during three of these outbursts (2003, 2004, and 2008). The goals of these observations were to investigate the presence of a jet, and to disentangle the various contributions constituting the spectral energy distribution (SED): accretion, ejection, and stellar emission.Methods. Photometric and spectroscopic OIR observations allowed us to produce a high time-resolution lightcurve in Ks-band, to analyze emission lines present in the IR spectra, to construct a multiwavelength SED including radio, IR, and X-ray data, and to complete the OIR vs. X-ray correlation of black hole binaries with H 1743-322 data points.Results. We detect rapid flares of duration ~5 min in the high time-resolution IR lightcurve. We identify hydrogen and helium emission lines in the IR spectra, coming from the accretion disk. The IR SED exhibits the spectral index typically associated with the X-ray high, soft state in our observations taken during the 2003 and 2004 outbursts, while the index changes to one that is typical of the X-ray low, hard state during the 2008 outburst. During this last outburst, we detected a change of slope in the NIR spectrum between the J and Ks bands, where the JH part is characteristic of an optically thick disk emission, while the HKs part is typical of optically thin synchrotron emission. Furthermore, the comparison of our IR data with radio and X-ray data shows that H 1743-322 exhibits a faint jet both in radio and NIR domains. Finally, we suggest that the companion star is a late-type main sequence star located in the Galactic bulge.Conclusions. These OIR photometric and spectroscopic observations of the microquasar H 1743-322, which are the first of this source to be published in a broad multiwavelength context, allow us to unambiguously identify two spectra of different origins in the OIR domain, evolving from optically thick thermal emission to optically thin synchrotron emission toward longer wavelengths. Comparing these OIR observations with other black hole candidates suggests that H 1743-322 behaves like a radio-quiet and NIR-dim black hole in the low, hard state. This study will be useful when quantitatively comparing the overall contribution of the compact jet and accretion flow in the energy budget of microquasars
Magnetically-Active Carbon Nanotubes at Work

Endohedral and exohedral assembly of magnetic nanoparticles (MNPs) and carbon nanotubes (CNTs) recently gave birth to a large body of new hybrid nanomaterials (MNPs-CNTs) featuring properties that are otherwise not in reach with only the graphitic or metallic cores themselves. These materials feature enhanced magnetically guided motions (rotation and translation), magnetic saturation and coercivity, large surface area, and thermal stability. By guiding the reader through the most significant examples in this Concept paper, we describe how researchers in the field engineered and exploited the synergistic combination of these two types of nanoparticles in a large variety of current and potential applications, such as magnetic fluid hyperthermia therapeutics and in magnetic resonance imaging to name a few
Obtaining a class of type O pure radiation metrics with a negative cosmological constant, using invariant operators

Using the generalised invariant formalism we derive a class of conformally
flat spacetimes whose Ricci tensor has a pure radiation and a Ricci scalar
component. The method used is a development of the methods used earlier for
pure radiation spacetimes of Petrov types O and N respectively. In this
paper we demonstrate how to handle, in the generalised invariant formalism,
spacetimes with isotropy freedom and rich Killing vector structure. Once the
spacetimes have been constructed, it is straightforward to deduce their
Karlhede classification: the Karlhede algorithm terminates at the fourth
derivative order, and the spacetimes all have one degree of null isotropy
and three, four or five Killing vectors.Officina Mathematica da Universidade do Minho.Vetenskapsrådet - Swedish Research Council
Taeniid species of the Iberian wolf (Canis lupus signatus) in Portugal with special focus on Echinococcus spp.

Taeniid species represent relevant pathogens in human and animals, circulating between carnivorous definitive hosts and a variety of mammalian intermediate hosts. In Portugal, however, little is known about their occurrence and life cycles, especially in wild hosts. An epidemiological survey was conducted to clarify the role of the Iberian wolf as a definitive host for taeniid species, including Echinococcus spp. Wolf fecal samples (n = 68) were collected from two regions in Northern Portugal. Taeniid eggs were isolated through a sieving-flotation technique, and species identification was performed using multiplex-PCR followed by sequencing of the amplicons. Taenia hydatigena (in 11.8% of the samples), Taenia serialis (5.9%), Taenia pisiformis (2.9%), Taenia polyacantha (1.5%) and Echinococcus intermedius (Echinococcus granulosus 'pig strain', G7) (1.5%) were detected. This is the first study to characterize the taeniid species infecting the Portuguese Iberian wolf, with the first records of T. polyacantha and E. intermedius in this species in the Iberian Peninsula. Iberian wolves can be regarded as relevant hosts for the maintenance of the wild and synanthropic cycles of taeniids in Portugal.U.Porto -Universidade do Port
Stem cells for cardiac regeneration

Recent studies have demonstrated a turnover of cardiomyocytes throughout the
adult life. Whether this regenerative potential is due to proliferation and
differentiation of resident stem cells or to the dedifferentiation of adult
cardiomyocytes remains unclear. Generation of new cardiomyocytes is critical
for cardiac repair following myocardial injury; however the mechanisms by
which injury responses modulate differentiation and proliferation of
cardiomyocyte progenitors is not clear.



In Study I, we show that sublethal apoptotic stimuli modulate the differentiation
of mouse embryonic stem cells (ESC) into cardiomyocytes through a caspasedependent mechanism. This indicates a direct link between caspase activation
and initiation of the cardiogenic programs. Further unfolding of these
mechanisms may have significant implications for the understanding of the
dynamics of cardiac regeneration after myocardial injury involving both
exogenous and endogenous cell sources.



The intrinsic regenerative capacity of human fetal cardiac mesenchymal stromal
cells (MSCs) has not been fully characterized. In Study II our aim was to
establish a culture protocol for large-scale expansion of human fetal cardiac
MSCs with characteristics of cardiovascular progenitor cells. By culturing the
cardiac MSCs on defined laminin (LN)-based substrata in combination with
stimulation of the canonical Wnt/β-catenin pathway we could generate multipotent cells which could differentiate into endothelial, smooth muscle cells, and
spontaneously beating cardiomyocytes. The expanded cardiac MSCs stained
positive for the progenitor markers: Pdgfr-α, Isl1, and Nkx2.5, and
subpopulations also expressed: Tbx18, Kdr, c-Kit, and Ssea-1. Our protocol for
large-scale culture of human fetal cardiac MSCs enables future exploration of
the regenerative functions of these cells in the context of myocardial injury in
vitro and in vivo.



Subsequently, in Study III we performed bioenergetic and metabolic profiling of
human fetal cardiac MSCs as a tool for investigating metabolic changes in
embryonic hearts during development. The critical role of metabolism in the
active control of cell renewal and lineage specification has recently come into
focus, and Wnt has been proposed as one of the signaling pathways which links
energy metabolism to cell fate decision. In the MSCs derived from hearts of
different gestational age, we observed an increase in oxidative metabolism
during first trimester of development. Finally, stimulation of the canonical
Wnt/β-catenin signaling pathway in hypoxia appeared to enhance long-term
MSC expansion, and resulted in a cell population with higher cardiogenic
differentiation potential. Our findings suggest that manipulation of metabolic
signals may facilitate endogenous stem cell activation, tissue renewal and
induction of cytoprotective properties
Measurement of the cross-section for b-jets produced in association with a Z boson at √s=7 TeV with the ATLAS detector

A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons, and at least one b-jet, identified by its displaced vertex, with transverse momentum p(T) > 25 GeV and rapidity vertical bar y vertical bar < 2.1. After subtraction of background processes, the yield is extracted from the vertex mass distribution of the candidate b-jets. The ratio of this cross-section to the inclusive Z cross-section (the average number of b-jets per Z event) is also measured. Both results are found to be in good agreement with perturbative QCD predictions at next-to-leading order
Observation of the $\varXi^{-}_{b}\to J/\psi\varLambda K^{-}$ decay

The observation of the decay $\varXi^{-}_{b}\to J/\psi\varLambda K^{-}$ is
reported, using a data sample corresponding to an integrated luminosity of
$3~\mathrm{fb}^{-1}$, collected by the LHCb detector in $pp$ collisions at
centre-of-mass energies of $7$ and $8~\mathrm{TeV}$. The production rate of
$\varXi_{b}^{-}$ baryons detected in the decay $\varXi_{b}^{-}\to
J/\psi\varLambda K^{-}$ is measured relative to that of $\varLambda_{b}^{0}$
baryons using the decay $\varLambda_{b}^{0}\to J/\psi \varLambda$. Integrated
over the $b$-baryon transverse momentum $p_{\rm T}<25~\mathrm{GeV/}c $ and
rapidity $2.0<y<4.5$, the measured ratio is \begin{equation*}
\frac{f_{\varXi_{b}^{-}}}{f_{\varLambda_{b}^{0}}}\frac{\mathcal{B}(\varXi_{b}^{-}\to
J/\psi\varLambda K^{-})}{\mathcal{B}(\varLambda_{b}^{0}\to J/\psi
\varLambda)}=(4.19\pm 0.29~(\mathrm{stat})\pm0.15~(\mathrm{syst}))\times
10^{-2}, \end{equation*}where $f_{\varXi_{b}^{-}}$ and $f_{\varLambda_{b}^{0}}$
are the fragmentation fractions of $b\to\varXi_{b}^{-}$ and
$b\to\varLambda_{b}^{0}$ transitions, and $\mathcal{B}$ represents the
branching fraction of the corresponding $b$-baryon decay. The mass difference
between $\varXi_{b}^{-}$ and $\varLambda_{b}^{0}$ baryons is measured to be
\begin{equation*}
M(\varXi_{b}^{-})-M(\varLambda_{b}^{0})=177.08\pm0.47~(\mathrm{stat})\pm0.16~(\mathrm{syst}
)~\mathrm{MeV/}c^{2}. \end{equation*}Comment: All figures and tables, along with any supplementary material and
  additional information, are available at
  https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-053.htm
A prospective development study investigating focal irreversible electroporation in men with localised prostate cancer: Nanoknife Electroporation Ablation Trial (NEAT).

INTRODUCTION: Focal therapy may reduce the toxicity of current radical treatments while maintaining the oncological benefit. Irreversible electroporation (IRE) has been proposed to be tissue selective and so might have favourable characteristics compared to the currently used prostate ablative technologies. The aim of this trial is to determine the adverse events, genito-urinary side effects and early histological outcomes of focal IRE in men with localised prostate cancer.
METHODS: This is a single centre prospective development (stage 2a) study following the IDEAL recommendations for evaluating new surgical procedures. Twenty men who have MRI-visible disease localised in the anterior part of the prostate will be recruited. The sample size permits a precision estimate around key functional outcomes. Inclusion criteria include PSA ≤ 15 ng/ml, Gleason score ≤ 4 + 3, stage T2N0M0 and absence of clinically significant disease outside the treatment area. Treatment delivery will be changed in an adaptive iterative manner so as to allow optimisation of the IRE protocol. After focal IRE, men will be followed during 12 months using validated patient reported outcome measures (IPSS, IIEF-15, UCLA-EPIC, EQ-5D, FACT-P, MAX-PC). Early disease control will be evaluated by mpMRI and targeted transperineal biopsy of the treated area at 6 months.
DISCUSSION: The NEAT trial will assess the early functional and disease control outcome of focal IRE using an adaptive design. Our protocol can provide guidance for designing an adaptive trial to assess new surgical technologies in the challenging landscape of health technology assessment in prostate cancer treatment
Inhabitants' and professionals' social representations of health determinants in a disadvantaged urban area in France: a qualitative analysis.

Access to care in French disadvantaged urban areas remains an issue despite the implementation of local healthcare structures. To understand this contradiction, we investigated social representations held by inhabitants of such areas, as well as those of social and healthcare professionals, regarding events or behaviours that can impact low-income individuals' health.
In the context of a health diagnosis, 288 inhabitants living in five disadvantaged districts of Aix-les-Bains, as well as 28 professionals working in these districts, completed an open-ended questionnaire. The two groups of respondents were asked to describe what could have an impact on health status from the inhabitants' point of view. The textual responses were analyzed using the Alceste method.
We observed a number of differences in the way the inhabitants and professionals represented determinants of health in disadvantaged urban areas: the former proposed a representation mixing personal responsibility with physiological, social, familial, and professional aspects, whereas the latter associated health issues with marginalization (financial, drug, or alcohol problems) and personal responsibility. Both inhabitants and professionals mentioned control over events and lifestyle as determinants of health.
The results are discussed regarding the consequences of these different representations on the beneficiary - healthcare-provider relationship in terms of communication and trust
Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb

Monocytes serve as a central defense system against infection and injury but can also promote pathological inflammatory responses. Considering the evidence that monocytes exist in at least two subsets committed to divergent functions, we investigated whether distinct factors regulate the balance between monocyte subset responses in vivo. We identified a microRNA (miRNA), miR-146a, which is differentially regulated both in mouse (Ly-6C[superscript hi]/Ly-6C[superscript lo]) and human (CD14[superscript hi]/CD14[superscript lo]CD16[superscript +]) monocyte subsets. The single miRNA controlled the amplitude of the Ly-6C[superscript hi] monocyte response during inflammatory challenge whereas it did not affect Ly-6C[superscript lo] cells. miR-146a-mediated regulation was cell-intrinsic and depended on Relb, a member of the noncanonical NF-κB/Rel family, which we identified as a direct miR-146a target. These observations not only provide mechanistic insights into the molecular events that regulate responses mediated by committed monocyte precursor populations but also identify targets for manipulating Ly-6C[superscript hi] monocyte responses while sparing Ly-6C[superscript lo] monocyte activity