pinecone/core-2020-05-10-deduplication huggingface dataset:
Monitoring for potential residual disease activity by serum insulin-like growth factor 1 and soluble Klotho in patients with acromegaly after pituitary surgery: is there an impact of the genomic deletion of exon 3 in the growth hormone receptor (d3-GHR) gene on "safe" GH cut-off values?

BACKGROUND: Acromegaly is an illness usually defined by excessively high growth hormone (GH) and insulin like growth factor 1 (IGF-1) levels, the latter mainly reflecting GH action on the liver. IGF-1, also known as somatomedin C, mediates several actions of GH. The diagnosis and management of acromegaly is relatively straight forward, but long-term follow-up of patients can be difficult, as elevated IGF-1 levels can occur in the presence of apparently normalised GH levels and late recurrence of acromegaly may arise despite previous suppression on oral glucose tolerance testing. Data suggest this applies especially to patients in whom the GH receptor lacks exon 3. In such patients, GH may not always be a useful marker of disease, and traditional GH cut-offs may be misleading. Recent data suggest that soluble Klotho (sKlotho), besides and in addition to IGF-1, may help monitor the activity of GH-producing adenomas (presumably reflecting GH action on the kidneys) and may be a useful supplementary tool.\ud
METHODS: GHR genotyping was performed in 112 patients with acromegaly. IGF-1 and sKlotho levels were measured in the sera of patients before and after transsphenoidal surgery, with emphasis on patients judged inconclusively cured by surgery or with small residual tumour masses shortly after surgery. Patients were assessed for recurrence of acromegaly with GH levels (random or nadir during an oGTT).\ud
RESULTS: Of the 48 patients who underwent surgery between 2000 and 2009 and who had well-documented longer term follow-up at our institution, 29 had no biochemical evidence of residual disease activity after transsphenoidal surgery (marked reduction in IGF-1 and sKlotho levels, GH suppressible to <1 ng/ml) and were classified as in remission. 2 of these patients developed recurrent symptoms of acromegaly during follow-up with increasing levels of IGF-1 and sKlotho, and both patients were carriers of the d3-GHR genotype.\ud
CONCLUSIONS: Acromegalic patients with the d3-GHR polymorphism might be - for a given low postsurgical GH level - at higher risk for recurrence and may require a lower GH nadir during oGTT to be classified as in remission. Soluble Klotho could be useful in the follow-up of acromegalic patients. The question arises whether sKlotho not only reflects the activity of GH-secreting pituitary adenomas but whether Klotho (ectodomain clipping?) could also mediate selected actions of GH
The effects of mergers and acquisitions on the firm size distribution.

This paper provides new empirical evidence on the effects of mergers and acquisitions (M&As) on the shape of the firm size distribution, by using data of the population of manufacturing firms in the Netherlands. Our analysis shows that M&As do not affect the size distribution when we consider the entire population of firms. When we focus on the firms involved in an M&A event, we observe a shift of the firm size distribution towards larger sizes. Firm size distribution becomes more concentrated around the mean, less skewed to the right hand side, and thinner at the tails as a whole. The shift toward higher sizes due to M&A is not uniform but affects firms of different sizes in different ways. While the number of firms in the lower tail decreased, the number of firms in the central size classes increased substantially and outweighed the increase in the number (and mean size) of firms in the upper tail of the distribution (consequently the overall market concentration measured by the Herfindahl index declines). M&As lead to a departure from log-normality of the firm size distribution, suggesting that external growth does not follow Gibrat’s law. Our counterfactual analysis highlights that only internal growth does not affect the shape of the size distribution of firms. On the contrary, it suggests that the change in the size distribution is almost entirely due to the external growth of the firms
Stability of personality traits in adulthood

Stability represents a fundamental concept in developmental theory and research. In this article we give an overview of recent work on personality traits and their stability in adulthood. First, we define personality traits and stability. Second, we present empirical evidence supporting change and stability of personality traits across the adult years with respect to conceptually and statistically different forms of stability. Third, we describe mechanisms and processes that enable trait stability. Finally, we discuss implications of trait stability for theory, research, and application
Data on clinical characteristics of a heart failure patients' cohort with reduced ejection fraction and analysis of the circulating values of five different heart failure biomarkers; high sensitivity troponin T, galectin-3, C-terminal propeptide of type I procollagen, soluble AXL and BNP

Altres ajuts: Fundació La Marató de TV3 (projecte 081010 i projecte 080121)In this article, the full description of a heart failure with reduced ejection fraction (HF_REF) cohort of 192 patients is provided. Tables with the baseline demographic, prior history, ECG parameters, echocardiographic parameters, laboratory values and pharmacological treatment of these patients are included. Also, the quartile values of the analyzed circulating biomarkers: high sensitivity Troponin T (hs-TnT), galectin-3 (Gal-3), C-terminal propeptide of type I procollagen (CICP), soluble AXL (sAXL) and Brain Natriuretic Peptide (BNP) are given. The main demographic and clinical features of the patients' subgroups that have hs-TnT, Gal-3, CICP or BNP above the third quartile are described. Tables with Pearson correlation analysis of the HF_REF patients' biomarker levels are included. And Pearson correlation analysis of the HF_REF patients' hs-TnT, Gal-3, CICP levels with patients' biochemical parameters, blood count and inflammation parameters are also described. These data are related to the research articles (AXL receptor tyrosine kinase is increased in patients with heart failure (M. Batlle, P. Recarte-Pelz, E. Roig, M.A. Castel, M. Cardona, M. Farrero, et al., 2014) [1] and Use of serum levels of high sensitivity troponin T, galectin-3 and C-terminal propeptide of type I procollagen at long term follow-up in Heart Failure patients with reduced ejection fraction: comparison with soluble AXL and BNP (M. Batlle, B. Campos, M. Farrero, M. Cardona, B. González, M.A. Castel, et al., 2016) [2]
Geometric morphometric analysis of grain shape and the identification of two-rowed barley (Hordeum vulgare subsp distichum L.) in southern France

Open Access funded by Natural Environment Research Council Under a Creative Commons license We would like to thank Michel Lemoine (CNRS, Muséum), for his invaluable help during the carbonization of the fresh caryopses. We are also most grateful to the society Secobra for providing the fresh caryopses used in this study, to Raphaël Cornette (UMR7205) for welcoming us into the morphometric platform of the National Museum of Paris, to prof. Jean- Frédéric Terral (University Montpellier 2) for his advice and to Elizabeth Kerr (UMR7209) and Nelly Gidaszewski (UMR7205) for language editing. A. Evin acknowledges financial support from the Natural Environment Research Council, UK (grant number NE/F003382/1). Finally, we would like to thank the UMR7209 (CNRS-MNHN), for financial support.Peer reviewedPublisher PD
The inverse problem for the Gross - Pitaevskii equation

Two different methods are proposed for the generation of wide classes of
exact solutions to the stationary Gross - Pitaevskii equation (GPE). The first
method, suggested by the work by Kondrat'ev and Miller (1966), applies to
one-dimensional (1D) GPE. It is based on the similarity between the GPE and the
integrable Gardner equation, all solutions of the latter equation (both
stationary and nonstationary ones) generating exact solutions to the GPE, with
the potential function proportional to the corresponding solutions. The second
method is based on the "inverse problem" for the GPE, i.e. construction of a
potential function which provides a desirable solution to the equation.
Systematic results are presented for 1D and 2D cases. Both methods are
illustrated by a variety of localized solutions, including solitary vortices,
for both attractive and repulsive nonlinearity in the GPE. The stability of the
1D solutions is tested by direct simulations of the time-dependent GPE
Quantum Criticality in Einstein-Maxwell-Dilaton Gravity

We investigate the quantum Lifshitz criticality in a general background of
Einstein-Maxwell-Dilaton gravity. In particular, we demonstrate the existence
of critical point with dynamic critical exponent z by tuning a nonminimal
coupling to its critical value. We also study the effect of nonminimal coupling
and exponent z to the Efimov states and holographic RG flow in the overcritical
region. We have found that the nonminimal coupling increases the instability
for a probe scalar to condensate and its back reaction is discussed. At last,
we give a quantum mechanics treatment to a solvable system with z=2, and
comment for generic z>2.Comment: 15 pages, 6 figures, revtex
Integrating out geometry: Holographic Wilsonian RG and the membrane
  paradigm

We formulate a holographic Wilsonian renormalization group flow for strongly
coupled systems with a gravity dual, motivated by the need to extract
efficiently low energy behavior of such systems. Starting with field theories
defined on a cut-off surface in a bulk spacetime, we propose that integrating
out high energy modes in the field theory should correspond to integrating out
a part of the bulk geometry. We describe how to carry out this procedure in
practice in the classical gravity approximation using examples of scalar and
vector fields. By integrating out bulk degrees of freedom all the way to a
black hole horizon, this formulation defines a refined version of the black
hole membrane paradigm. Furthermore, it also provides a derivation of the
semi-holographic description of low energy physics.Comment: 21 pages, 2 figures; references added, minor change
Analysis of the pi^+pi^-pi^+pi^- and pi^+pi^0pi^-pi^0 Final States in
  Quasi-Real Two-Photon Collisions at LEP

The reactions gamma gamma -> pi^+pi^-pi^+pi^- and gamma gamma ->
pi^+pi^0pi^-pi^0 are studied with the L3 detector at LEP in a data sample
collected at centre-of-mass energies from 161GeV to 209GeV with a total
integrated luminosity of 698/pb. A spin-parity-helicity analysis of the rho^0
rho^0 and rho^+ rho^- systems for two-photon centre-of-mass energies between
1GeV and 3GeV shows the dominance of the spin-parity state 2+ with helicity 2.
The contribution of 0+ and 0- spin-parity states is also observed, whereas
contributions of 2- states and of a state with spin-parity 2+ and zero helicity
are found to be negligible
The SM prediction of g-2 of the muon

We calculate (g-2)/2 of the muon, by improving the determination of the
hadronic vacuum polarisation contribution, a_mu^{had,LO}, and its
uncertainties. The different e+e- data sets for each exclusive (and the
inclusive) channel are combined in order to obtain the optimum estimate of the
cross sections and their uncertainties. QCD sum rules are evaluated in order to
resolve an apparent discrepancy between the inclusive data and the sum of the
exclusive channels. We conclude a_mu^{had,LO}=(683.1 +- 5.9_{exp} +- 2.0_{rad})
10^{-10} which, when combined with the other contributions to (g-2)/2, is about
3 sigma below the present world average measurement.Comment: 8 pages, LaTeX, 3 PostScript figures included. For completeness, we
  have added a recent prediction of the hadronic contribution by F. Jegerlehne
Saddle-Node Bifurcation Associated with Parasitic Inductor Resistance in
  Boost Converters

Saddle-node bifurcation occurs in a boost converter when parasitic inductor
resistance is modeled. Closed-form critical conditions of the bifurcation are
derived. If the parasitic inductor resistance is modeled, the saddle-node
bifurcation occurs in the voltage mode control or in the current mode control
with the voltage loop closed, but not in the current mode control with the
voltage loop open. If the parasitic inductor resistance is not modeled, the
saddle-node bifurcation does not occur, and one may be misled by the wrong
dynamics and the wrong steady-state solutions. The saddle-node bifurcation
still exists even in a boost converter with a popular type-III compensator.
When the saddle-node bifurcation occurs, multiple steady-state solutions may
coexist. The converter may operate with a voltage jump from one solution to
another. Care should be taken in the compensator design to ensure that only the
desired solution is stabilized. In industry practice, the solution with a
higher duty cycle (and thus the saddle-node bifurcation) may be prevented by
placing a limitation on the maximum duty cycle.Comment: Minor revision from a manuscript dated in 201
f_0(1710) production in exclusive B decays

Production of $f_0(1710)$, a theoretical endeavor of pure scalar glueball
state, is studied in detail from exclusive rare B decay within the framework of
perturbative QCD. The branching fraction for $B^\pm \to K^{*\pm} f_0(1710) \to
K^{*\pm} (K \bar K)$ is estimated to be about $8 \times 10^{-6}$, while for
$B^\pm \to K^\pm f_0(1710) \to K^\pm (K \bar K)$ it is smaller by roughly an
order of magnitude. With the accumulation of almost 1 billion $B \bar B$ pairs
from the B{\tiny A}B{\tiny AR} and Belle experiments to date, hunting for a
scalar glueball via these rare decay modes should be attainable.Comment: 20 pages, 4 figures, 6 tables. Published version. To appear in PL
DIGIT survey of far-infrared lines from protoplanetary disks I

[abridged] We present far-infrared spectroscopic observations of PMS stars
taken with Herschel/PACS as part of the DIGIT key project. The sample includes
22 Herbig AeBe and 8 T Tauri sources. Multiple atomic fine structure and
molecular lines are detected at the source position: [OI], [CII], CO, OH, H_2O,
CH^+. The most common feature is the [OI] 63micron line detected in almost all
of the sources followed by OH. In contrast with CO, OH is detected toward both
Herbig AeBe groups (flared and non-flared sources). An isothermal LTE slab
model fit to the OH lines indicates column densities of 10^13 < N_OH < 10^16
cm^-2, emitting radii 15 < r < 100 AU and excitation temperatures 100 < T_ex <
400 K. The OH emission thus comes from a warm layer in the disk at intermediate
stellar distances. Warm H_2O emission is detected through multiple lines toward
the T Tauri systems AS 205, DG Tau, S CrA and RNO 90 and three Herbig AeBe
systems HD 104237, HD 142527, HD 163296 (through line stacking). Overall,
Herbig AeBe sources have higher OH/H_2O abundance ratios across the disk than
do T Tauri disks, from near- to far-infrared wavelengths. Far-infrared CH^+
emission is detected toward HD 100546 and HD 97048. The slab model suggests
moderate excitation (T_ex ~ 100 K) and compact (r ~ 60 AU) emission in the case
of HD 100546. The [CII] emission is spatially extended in all sources where the
line is detected. This suggests that not all [CII] emission is associated with
the disk and that there is a substantial contribution from diffuse material
around the young stars. The flux ratios of the atomic fine structure lines are
consistent with a disk origin for the oxygen lines for most of the sources.Comment: Accepted for publication in A&
Charm mixing as input for model-independent determinations of the CKM
  phase gamma

The coherence factor and average strong phase difference of D0 and D0bar
decay amplitudes to the same final state play an important role in the
precision determination of the CKM parameter gamma using B- -> DK- and related
decay modes. So far, this important input from the charm sector could only be
obtained from measurements based on quantum-correlated DDbar pairs produced at
the charm threshold. We propose to constrain these parameters using charm
mixing, using the large charm samples available at the B factories and LHCb. We
demonstrate for the example of D0->Kpipipi that a substantial improvement in
the precision of the coherence factor and average strong phase difference can
be obtained with this method, using existing data.Comment: Accepted for publication in PL
A Nonabelian $(1,0)$ Tensor Multiplet Theory in 6D

We construct a general nonabelian (1,0) tensor multiplet theory in six
dimensions. The gauge field of this (1,0) theory is non-dynamical, and the
theory contains a continuous parameter $b$. When $b=1/2$, the (1,0) theory
possesses an extra discrete symmetry enhancing the supersymmetry to (2,0), and
the theory turns out to be identical to the (2,0) theory of Lambert and
Papageorgakis (LP). Upon dimension reduction, we obtain a general ${\cal N}=1$
supersymmetric Yang-Mills theory in five dimensions. The applications of the
theories to D4 and M5-branes are briefly discussed.Comment: 18 pages, published in JHEP. minor changes, references adde
Resolvent estimates for high-contrast elliptic problems with periodic
  coefficients

We study the asymptotic behaviour of the resolvents $({\mathcal
A}^\varepsilon+I)^{-1}$ of elliptic second-order differential operators
${\mathcal A}^\varepsilon$ in ${\mathbb R}^d$ with periodic rapidly oscillating
coefficients, as the period $\varepsilon$ goes to zero. The class of operators
covered by our analysis includes both the "classical" case of uniformly
elliptic families (where the ellipticity constant does not depend on
$\varepsilon$) and the "double-porosity" case of coefficients that take
contrasting values of order one and of order $\varepsilon^2$ in different parts
of the period cell. We provide a construction for the leading order term of the
"operator asymptotics" of $({\mathcal A}^\varepsilon+I)^{-1}$ in the sense of
operator-norm convergence and prove order $O(\varepsilon)$ remainder estimates.Comment: 20 page
Vortex Zero Modes, Large Flux Limit and Ambj{\o}rn-Nielsen-Olesen
  Magnetic Instabilities

In the large flux limit vortices become flux tubes with almost constant
magnetic field in the interior region. This occurs in the case of non-Abelian
vortices as well, and the study of such configurations allows us to reveal a
close relationship between vortex zero modes and the gyromagnetic instabilities
of vector bosons in a strong background magnetic field discovered by Nielsen,
Olesen and Ambj{\o}rn. The BPS vortices are exactly at the onset of this
instability, and the dimension of their moduli space is precisely reproduced in
this way. We present a unifying picture in which, through the study of the
linear spectrum of scalars, fermions and W bosons in the magnetic field
background, the expected number of translational, orientational, fermionic as
well as semilocal zero modes is correctly reproduced in all cases.Comment: 22 pages, 10 figure
Constructing Classical and Quantum Superconformal Algebras on the
  Boundary of AdS_3

Motivated by recent progress on the correspondence between string theory on
anti-de Sitter space and conformal field theory, we address the question of
constructing space-time N extended superconformal algebras on the boundary of
AdS_3. Based on a free field realization of an affine SL(2|N/2) current
superalgebra residing on the world sheet, we construct explicitly the Virasoro
generators and the N supercurrents. N is even. The resulting superconformal
algebra has an affine SL(N/2) \otimes U(1) current algebra as an internal
subalgebra. Though we do not complete the general superalgebra, we outline the
underlying construction and present supporting evidence for its validity.
Particular attention is paid to its BRST invariance. In the classical limit
where the free field realization may be substituted by a differential operator
realization, we discuss further classes of generators needed in the closure of
the algebra. We find sets of half-integer spin fields, and for N>4 these
include generators of negative weights. An interesting property of the
construction is that for N>2 it treats the supercurrents in an asymmetric way.
Thus, we are witnessing a new class of superconformal algebras not obtainable
by conventional Hamiltonian reduction. The complete classical algebra is
provided in the case N=4 and is of a new and asymmetric form.Comment: 29 pages, LaTeX, extends hep-th/990518
More on the universality of the Volkov-Akulov action under N = 1
  nonlinear supersymmetry

We discuss further the universality of the Volkov-Akulov (V-A) action of a
Nambu-Goldstone (N-G) fermion for the spontaneous breaking of supersymmetry
(SUSY). We show general relations between the standard V-A action and nonlinear
(NL) SUSY actions including apparently (pathological) higher derivatives of the
N-G fermion. Composite fields of the N-G fermions are found, which transform
homogeneously under NL SUSY transformations of V-A. Consequently, we obtain NL
SUSY invariant constraints which connect our NL SUSY actions with the V-A
action. The constraints are explicitly solved and we show examples of the NL
SUSY actions which are equivalent to the V-A action.Comment: 10pages, Late
Can our Universe be inhomogeneous on large sub-horizon scales?

We show that our Universe may be inomogeneous on large sub-horizon scales without us being able to realise it. We assume that a network of domain walls permeates the universe dividing it in domains with slightly different vacuum energy densities. We require that the energy scale of the phase transition which produced the domain walls is sufficiently low so that the walls have a negligible effect on structure formation. Nevertheless, the different vacuum densities of different domains will lead to different values of the cosmological parameters $\Omega_\Lambda^0$, $\Omega_m^0$ and $h$, in each patch thus affecting the growth of cosmological perturbations at recent times. Hence, if our local patch of the universe (with uniform vacuum density) is big enough -- which is likely to happen given that we should have on average about one domain per horizon volume -- we might not notice these large-scale inomogeneities. This happens because in order to see a patch with a different vacuum density one may have to look back at a time when the universe was still very homogeneous
Search for heavy neutrinos mixing with $\tau$ neutrinos

We report on a search for heavy neutrinos ($\nus$) produced in the decay $D_s\to \tau \nus$ at the SPS proton target followed by the decay $\nudecay$ in the NOMAD detector.\ Both decays are expected to occur if $\nus$ is a component of $\nu_{\tau}$.\ From the analysis of the data collected during the 1996-1998 runs with $4.1\times10^{19}$ protons on target, a single candidate event consistent with background expectations was found.\ %No evidence for this decay chain has been found This allows to derive for the first time an upper limit on the mixing strength between the heavy neutrino and the tau neutrino in the $\nus$ mass range from 10 to 190 $\rm MeV$.\ Windows between the SN1987a and Big Bang Nucleosynthesis lower limits and our result are still open for future experimental searches.\ The results obtained are used to constrain an interpretation of the time anomaly observed in the KARMEN1 detector
Multi-loop Amplitudes and Ressumation

We explore the relation between resummation and explicit multi-loop calculations for QCD hard-scattering amplitudes. We describe how the factorization properties of amplitudes lead to the exponentiation of double and single poles at each order of perturbation theory. For these amplitudes, previously-observed relations between single and double poles in different 2 to 2 processes can now be interpreted in terms of universal functions associated with external partons and process-dependent anomalous dimensions that describe coherent soft radiation. Catani's proposal for multiple poles in dimensionally-continued amplitudes emerges naturally