pinecone/core-2020-05-10-deduplication huggingface dataset:
Scope of partial least-squares regression applied to the enantiomeric composition determination of ketoprofen from strongly overlapped chromatographic profiles

Valuable quantitative information could be obtained from strongly overlapped chromatographic profiles of two enantiomers by using proper chemometric methods. Complete separation profiles where the peaks are fully resolved are difficult to achieve in chiral separation methods, and this becomes a particularly severe problem in case that the analyst need to measure the chiral purity, i.e., when one of the enantiomers is present in the sample in very low concentrations. In this report, we explore the scope of a multivariate chemometric technique based on unfolded partial least-squares regression, as a mathematical tool to solve this quite frequent difficulty. This technique was applied to obtain quantitative results from partially overlapped chromatographic profiles of R- and S-ketoprofen, with different values of enantioresolution factors (from 0.81 down to less than 0.2 resolution units), and also at several different S:R enantiomeric ratios. Enantiomeric purity below 1% was determined with excellent precision even from almost completely overlapped signals. All these assays were tested on the most demanding condition, i.e., when the minor peak elutes immediately after the main peak. The results were validated using univariate calibration of completely resolved profiles and the method applied to the determination of enantiomeric purity of commercial pharmaceuticals.Fil: Padro, Juan Manuel. Universidad Nacional de la Plata. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Osorio Grisales, Jaiver. Universidad Nacional de la Plata. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arancibia, Juan Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Olivieri, Alejandro Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Castells, Cecilia Beatriz Marta. Universidad Nacional de la Plata. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
High-performance liquid chromatography separation of unsaturated organic compounds by a monolithic silica column embedded with silver nanoparticles.

Article first published online: 15 JUL 2015The optimization of a porous structure to ensure good separation performances is always a significant issue in high-performance liquid chromatography column design. Recently we reported the homogeneous embedment of Ag nanoparticles in periodic mesoporous silica monolith and the application of such Ag nanoparticles embedded silica monolith for the high-performance liquid chromatography separation of polyaromatic hydrocarbons. However, the separation performance remains to be improved and the retention mechanism as compared with the Ag ion high-performance liquid chromatography technique still needs to be clarified. In this research, Ag nanoparticles were introduced into a macro/mesoporous silica monolith with optimized pore parameters for high-performance liquid chromatography separations. Baseline separation of benzene, naphthalene, anthracene, and pyrene was achieved with the theoretical plate number for analyte naphthalene as 36, 000 m(-1). Its separation function was further extended to cis/trans isomers of aromatic compounds where cis/trans stilbenes were chosen as a benchmark. Good separation of cis/trans-stilbene with separation factor as 7 and theoretical plate number as 76, 000 m(-1) for cis-stilbene was obtained. The trans isomer, however, is retained more strongly, which contradicts the long- established retention rule of Ag ion chromatography. Such behavior of Ag nanoparticles embedded in a silica column can be attributed to the differences in the molecular geometric configuration of cis/trans stilbenes
Effect of the flow profile on separation efficiency in pressure-assisted reversed-polarity capillary zone electrophoresis of anions: Simulation and experimental evaluation

Capillary electrophoresis connected to electrospray ionization mass spectrometry is a promising combination to analyze complex biological samples. The use of sheathless electrospray ionization interfaces, such as a porous nanoelectrospray capillary emitter, requires the application of forward flow (either by pressure or electroosmosis) to maintain the electrospray process. The analysis of solute molecules with strong negative charges (e.g., aminopyrenetrisulfonate labeled glycans)\ud
necessitates a reversed-polarity capillary electrophoresis separation mode, in which case the electroosmotic flow is counter current, thus pressure assistance is necessary. In this study, we compared the effect of forced convection with and without counter electroosmotic flow on the resulting separation efficiency in capillary electrophoresis based on flow profile simulations by computational fluid dynamics technique and by actual experiments. The efficiencies of the detected peaks were calculated from the resulting electropherograms and found approximately 790 000 plates/m for electrophoresis with counter electroosmotic flow, 16 000 plates/m with pressure only (such as would be in open tubular liquid chromatography) and 400 000 plates/m for electrophoresis with simultaneous counter electroosmotic flow and forward pressure assistance, which validates the simulation data
Bowler analysis in cricket using centre of mass inertial monitoring

Bowling in cricket requires accuracy, repeatability, and speed control. Incorrect bowling action can result in poor performance and injury to the shoulder, lower back, and knee joints. In this paper, we present a wearable wireless technology suitable for everyday use by elite and recreational athletes alike. Wireless monitoring of front-on bowler actions using inertial sensors placed in the centre of mass results in clear signals, which can be interpreted in terms of run-up speed and length and hip rotation. For a bowler who was bowling submaximally, the run-up speed was 2.7 m/s with a predelivery stride length of 1.2 m/s and a hip rotation of 401. This simple, inexpensive technique allows in-field bowling assessment and analysis and promises to be a significant training aid.Griffith Sciences, Griffith School of EngineeringFull Tex
Internet-enabled tourism entrepreneurs. International entrepreneurial values elicited through repertory test and laddering analysis

Although the tourism industry has been dramatically altered due to the Internet, there has been limited research published about international entrepreneurial values and Internet use in tourism firms. The findings of this study point to a relationship between the values of Internet-enabled international entrepreneurs in small-sized to medium-sized enterprises and the inclination of the firm to develop and initiate international activity. The findings of this study suggest that Internet-enabled tourism entrepreneurs share similar construct values. Two effective but underutilized qualitative methods were used in this study. The first method, repertory test, is an efficient technique for exploring constructs in decision making; the second method, laddering analysis, facilitates understanding of the perceived consequences and personal values guiding behaviour
Dive tourism and local communities: active participation or passive impacts? Case studies from Malaysia.

For many Less Developed Countries international tourism has long been considered a driver for economic development (OECD, 1967). However, tourism has also been heavily criticised for its negative environmental and cultural impacts and significant economic leakages due to the dependence of many host countries on large trans-national corporations (Mowforth and Munt, 2003). Specialist tourism forms such as eco-tourism or small-scale locally owned tourism have been promoted in response to these criticisms,with benefits advocated for local communities, greater cultural awareness by tourists and\ud
more controllable environmental impacts (Weaver, 2001; Scheyvens, 2002; Hampton,2005).\ud
Using local participation approaches, this Working Paper examines dive tourism\ud
as a form of niche tourism and assesses its impacts on local host communities. It investigates whether, or to what extent, active local participation is possible, and how far host communities are merely exposed to ‘passive’ impacts of dive tourism.\ud
The study covered three research locations in Malaysia and revealed that many\ud
aspects of local community life were affected by dive tourism. Besides physical changes such as new infrastructure, the study showed varied economic impacts for local communities through the existence (or lack of)employment/business opportunities, and differing levels of economic linkages, notably the purchase of goods and services between the dive industry and host villages. Local participation varied between locations and a number of obstacles to increased participation were revealed. Furthermore, impacts\ud
on local culture and society were observed as well as a lack of participation in possible cultural productions (handicrafts, performances) by local host communities. As a consequence of the dive industry’s initiatives however, positive educational impacts were noted, especially concerning environmental awareness and English language acquisition
Conjoint Analysis of Tourist Choice of Hotel Attributes Presented in Travel Agent Brochures

The purposes of this study are to demonstrate how it is possible to determinewhich attributes are the most important in the final choices of tourists who use a travel agent brochure as a source of information and how these attributes influence perceived value in a pre-purchase stage.We conduct the study in three phases: (i) a qualitative study, (ii) an experiment using choice-based conjoint analysis by means of a fractional factorial experimental design and (iii) another experiment using a full factorial derived from the same design. Results suggest advertisement size, a hotel's starred rating and price influence perceived value at this stage. The presence of a positive combined effect of price and advertising was found. Implications and directions for future applications are offered,focusing particularly on marketing services
Conjoint Analysis of Tourist Choice of Hotel Attributes Presented in Travel Agent Brochures

The purposes of this study are to demonstrate\ud
how it is possible to determine which attributes are the most important in the final choices of tourists who use a travel agent brochure as a source of information and how these attributes influence perceived value in a pre-purchase stage.We conduct the study in three phases: (i) a qualitative study, (ii) an experiment using choice-based conjoint analysis by means of a fractional factorial experimental design and (iii) another experiment using a full factorial\ud
derived from the same design. Results suggest\ud
advertisement size, a hotel’s starred rating and price influence perceived value at this stage. The presence of a positive combined effect of price and advertising was found. Implications and directions for future applications are offered, focusing particularly on marketing services.Postprint (published version
Geographic information systems in the pay of alternative tourism  – methods with landscape evaluation and target group preference weighting

There is a large variety of types of rural areas and many of them are rich in landscape beauty. However, their preserved culture and traditions are revalued in today’s rapid transformation of lifestyles. Alternative tourism is thus an emerging potential to economically support these areas, at the same time helps to preserve natural and cultural heritage. The methods provide sophisticated means to analyse the characteristics and the potential attractiveness of landscape and cultural attractions from the viewpoint of alternative tourism development. Homogenous tourism sub-regions can be defined and the most suitable development scenarios can be found to the certain areas
Tourism demand forecasting with neural network models : Different ways of treating information

This paper aims to compare the performance of three different artificial neural network techniques for tourist demand forecasting: a multi-layer perceptron, a radial basis function and an Elman network. We find that multi-layer perceptron and radial basis function models outperform Elman networks. We repeated the experiment assuming different topologies regarding the number of lags used for concatenation so as to evaluate the effect of the memory on the forecasting results. We find that for higher memories, the forecasting performance obtained for longer horizons improves, suggesting the importance of increasing the dimensionality for long-term forecasting
Causal Maps and Indirect Influences Analysis in the Diagnosis of Second-Home Tourism Impacts

This paper proposes a method for diagnosing the impacts of second-home tourism and illustrates it for a Mediterranean Spanish destination. This method proposes the application of network analysis software to the analysis of causal maps in order to create a causal network model based on stakeholder-identified impacts. The main innovation is the analysis of indirect relations in causal maps for the identification of the most influential nodes in the model. The results show that the most influential nodes are of a political nature, which contradicts previous diagnoses identifying technical planning as the ultimate cause of problems.The project described in this paper was funded by the Spanish Ministry of Science and Education under the title Residential tourism: analysis of demand and proposals for restructuring consolidated destinations (SEJ/2005/04305)
Different but similar: Social comparison of travel motives among tourists

Although previous research suggests that people prefer to think of themselves as being authentic (or individualistic) travellers rather than stereotyped tourists, there have been few studies investigating the external validity of such claim. This paper addresses this research gap by investigating tendencies to dissociate the self from typical tourists in terms of travel motivation. Findings suggest that people perceive their own travel motives to be different from those who they perceive as typical tourists and that these tendencies generalize across people involved in different forms of tourism. This paper discusses the results from a social psychological perspective and provides implications for future research and destination management alike
Backpacking through an ontology of becoming : a never‐ending cycle of journeys

By adopting an ontological stance of becoming, this study traces qualitatively the journeys of contemporary backpacker tourists using the theoretical construct of the 'Hero's Journey' as a conceptual vehicle. This process allows for the development of a cyclical model of experience that illustrates the backpacker's experience in three stages of departure, initiation and return. This approach reveals the role that former backpackers play through the sharing of knowledge and the invaluable support they offer to novice backpackers through a network of support that is available to contemporary backpackers who choose to follow established backpacking trails. This never ending cycle of journeys becomes instrumental into the shaping of what this paper see as the common, collective consciousness of the backpacking experience and the evolution of the backpacking experience market
Social Tourism and Healthy Ageing

Recent research in social tourism notes possible links between tourism participation and improvements in health. However, there is a lack of quantitative evidence concerning the potential links between tourism participation and self-reported health amongst older people. An ageing society requires measures to promote independent living and enhance older people's quality of life. This paper provides evidence that older tourists are more active and healthy than non-tourists, from a study comparing health perceptions amongst Spanish older people. The results provide tentative conclusions of causal relationships between tourism and dimensions of physical and mental health through a Structural Equation Model
The RAE-ification of Tourism Research in the UK

Whereas those working on the inside of tourism generally feel that tourism research is making good progress, the 2001 Research Assessment Exercise (RAE) in the UK offered an outsiders' assessment of UK tourism research that was less benign. This paper examines the results and consequences of the RAE based on an examination of the submissions made by UK higher education institutions. It describes the position of tourism in the RAE and focuses on three key issues—structure, outcomes and visibility. It invokes Kuhnian and Foucauldian perspectives to foreground hidden consequences of the RAE (termed RAE-ification by the author) that threaten the development of UK tourism research. The article concludes that tourism research, finding itself on the periphery of UK research, faces similar problems to those faced by peripheral tourism regions
Selling adventure tourism : A distribution channels perspective

This article examines the distribution channels structure as well as the underlying factors influencing the most prominent channel choices within the adventure tourism industry. It is based on in-depth interviews with adventure tourism operators in Queenstown, New Zealand. The findings suggest that the distribution structure is similar to other attraction sectors and that business size has some bearing on the ‘length’ of the distribution chains. However, regardless of business size the sector places a clear priority on ‘at destination’ distribution and the factors underlying this choice were found to be varied and reflective of both sector-specific demand and supply characteristics
Using the Delphi method to assess the potential of Taiwan's hot springs tourism sector

The purpose of the present study is to identify the various factors that influence the competitiveness of the hot springs tourism sector. The research draws on the models of Ritchie and Crouch, Dwyer and Kim, and Enright and\ud
Newton, who concluded that destination competitiveness is determined by three major components: resources and attractors, destination strategies and environments.\ud
The investigation produced both qualitative and quantitative data using the Delphi technique. An expert panel reached consensus about priorities for the development of Taiwan’s hot springs tourism sector and provided written justifi cations for their responses. This paper reports on the qualitative fi ndings of the\ud
three-round Delphi survey and provides a supply-side perspective on Taiwan’s hot springs tourism sector. An examination of the expert comments concluded that\ud
the Taiwanese are increasingly concerned with good health and longevity. This emerging characteristic offers new business opportunities for the providers of hot springs tourism experiences to extend their appeal into health protection and medical treatments. However, if they are to achieve sustainable development and ensure highquality\ud
visitor experiences, hot springs proprietors will need to work closely with local governments and communities to\ud
promote sustainable use of natural hot springs and to conduct routine inspections of spa premises. Overall, the future of the hot springs tourism sector appears to be\ud
promising
An Evaluation of Satisfaction Levels Among Chinese Tourists in Vietnam

This paper examines the extent to which\ud
Vietnam satisfi es the various destination\ud
attributes sought by Chinese tourists. The\ud
research investigates a number of variables,\ud
including socio-demographics and travel\ud
characteristics, and compares the importance\ud
that travellers attach to various destination\ud
attributes with their associated satisfaction\ud
with Vietnam’s various tourism products.\ud
By investigating the relationship between\ud
importance and satisfaction from the\ud
perspective of Chinese tourists, the paper\ud
makes a contribution to the literature. The\ud
fi ndings should provide Vietnamese service\ud
providers with insights into the perceptions\ud
and satisfaction levels of Chinese tourists
Attributes Affecting the Level of Tourist Satisfaction with and Loyalty towards Theatrical Performance in China: Evidence from a Qualitative Study

This study seeks to explore attributes affecting the level of tourist satisfaction with and loyalty towards theatrical performance in China. Based on four focus group discussions with 31 participants, the study identifies 34 attributes that affect the level of tourist satisfaction with theatrical performance, and groups them into five categories: stage, performance, venue, service and tourist-related attributes. The findings on tourist loyalty reveal that 21 of the 31 respondents would not watch the same theatrical performance alone in the future; however, they would recommend it to others. The study concludes with a discussion of the rich and insightful findings and their implications for tourism industry practitioners.Full Tex
Assessing Mainland Chinese Tourists' Satisfaction with Hong Kong Using Tourist Satisfaction Index

The purpose of this study is to test a two-step tourist satisfaction index framework empirically. The first step estimates sectoral-level satisfaction indexes based on a structural equation model, and the second obtains an overall tourist satisfaction index by conducting second-order confirmatory factor analysis. This study is a pilot test of the theoretical framework based on three tourism-related service sectors in Hong Kong. The results indicate that mainland Chinese tourists are most satisfied with the hotel sector in Hong Kong, followed by the retail sector, and least satisfied with local tour operators. The aggregate tourist satisfaction index is 74.04 out of 100. The results of this study have important practical implications for long-term destination management
The European timeshare consumer in the twenty - first century

This paper outlines the results of the most recent pan-European survey of timeshare and its owners. The paper begins by placing timeshare in context of the European leisure sector and outlining previous research on timeshare. It then goes on to examine the results of a major survey of timeshare owners and the industry. The results unveil the profile of timeshare owners in Europe, their purchasing behaviour and their future intentions; it also looks into the satisfaction of the timeshare experience. The survey demonstrates that timeshare represents a significant sector of the European accommodation market a d that in general, consumers have a high satisfaction rate with their use of timeshare
The challenges of marketing destinations in the Central African sub-region: The Cameroon example

During the last decade, Sub-Saharan Africa has consistently posted the one of the highest tourism growth with rates at an average +6% p.a. between 2007 and 2010. However, not all countries have profited from this growth. Countries in the Central African sub-region, which even though recognised internationally as potential hotspots for sustainable ecotourism development are still lagging behind those located in Western, Eastern and Southern Africa. This paper identifies some challenges inhibiting the development and marketing tourism destinations in the Central African sub-region and Cameroon in particular and proposes some concise measures whose implementation would help in redressing the situation