pinecone/core-2020-05-10-deduplication huggingface dataset:
Planck intermediate results: XXVII. High-redshift infrared galaxy overdensity candidates and lensed sources discovered by Planck and confirmed by Herschel-SPIRE

We have used the Planck all-sky submillimetre and millimetre maps to search for rare sources distinguished by extreme brightness, a few hundred millijanskies, and their potential for being situated at high redshift. These "cold" Planck sources, selected using the High Frequency Instrument (HFI) directly from the maps and from the Planck Catalogue of Compact Sources (PCCS), all satisfy the criterion of having their rest-frame far-infrared peak redshifted to the frequency range 353-857 GHz. This colour-selection favours galaxies in the redshift range z = 2-4, which we consider as cold peaks in the cosmic infrared background. With a 4.´5 beam at the four highest frequencies, our sample is expected to include overdensities of galaxies in groups or clusters, lensed galaxies, and chance line-of-sight projections. We perform a dedicated Herschel-SPIRE follow-up of 234 such Planck targets, finding a significant excess of red 350 and 500μm sources, in comparison to reference SPIRE fields. About 94% of the SPIRE sources in the Planck fields are consistent with being overdensities of galaxies peaking at 350μm, with 3% peaking at 500μm, and none peaking at 250μm. About 3% are candidate lensed systems, all 12 of which have secure spectroscopic confirmations, placing them at redshifts z> 2.2. Only four targets are Galactic cirrus, yielding a success rate in our search strategy for identifying extragalactic sources within the Planck beam of better than 98%. The galaxy overdensities are detected with high significance, half of the sample showing statistical significance above 10σ. The SPIRE photometric redshifts of galaxies in overdensities suggest a peak at z ≃ 2, assuming a single common dust temperature for the sources of Td = 35 K. Under this assumption, we derive an infrared (IR) luminosity for each SPIRE source of about 4 × 1012L⊙, yielding star formation rates of typically 700 M⊙ yr-1. If the observed overdensities are actual gravitationally-bound structures, the total IR luminosity of all their SPIRE-detected sources peaks at 4 × 1013L⊙, leading to total star formation rates of perhaps 7 × 103M⊙ yr-1 per overdensity. Taken together, these sources show the signatures of high-z (z> 2) protoclusters of intensively star-forming galaxies. All these observations confirm the uniqueness of our sample compared to reference samples and demonstrate the ability of the all-skyPlanck-HFI cold sources to select populations of cosmological and astrophysical interest for structure formation studies
Search for WZ resonances in the fully leptonic channel using pp collisions at s√ = 8 TeV with the ATLAS detector

A search for resonant WZ   production in the ℓνℓ′ℓ′ℓνℓ′ℓ′ (ℓ,ℓ′=e,μℓ,ℓ′=e,μ) decay channel using 20.3 fb−1 of View the MathML sources=8 TeVpp   collision data collected by the ATLAS experiment at LHC is presented. No significant deviation from the Standard Model prediction is observed and upper limits on the production cross sections of WZ   resonances from an extended gauge model W′W′ and from a simplified model of heavy vector triplets are derived. A corresponding observed (expected) lower mass limit of 1.52 (1.49) TeV is derived for the W′W′ at the 95% confidence level.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COL-CIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT and NSRF, Greece; ISF, MINERVA, GIF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW and NCN, Poland; GRICES and FCT, Portugal; MNE/IFA, Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America
Search for R-parity-violating supersymmetry in events with four or more leptons in √s =7 TeV pp collisions with the ATLAS detector

Journal of High Energy Physics 2012.12 (2012): 124 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMA search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fb-1 of √s =7 TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 4
Polymorphic Phase Transformation of Degussa P25 TiO2 by the Chelation of Diaminopyridine on TiO62- Octahedron: Correlation of Anatase to Rutile Phase Ratio on the Photocatalytic Activity

A series of nitrogen-doped Degussa P25 photocatalysts were synthesized successfully by grinding and calcination method using 2,6-diaminopyridine (DAP) as a nitrogen precursor. The prepared samples were characterized by various analytical methods. The phase contents of anatase and rutile in the Degussa P25 powders have been altered by simply changing the proportion of DAP. A mechanism involving chelated DAP molecule on TiO62- octahedron is discussed. The enhanced activity is attributed to synergistic effect in the two phase solid material. Due to the low activation barrier, the effective inter particle electron transfer between the two polymorphs is quite efficient only when they are in close proximity with similar crystallite sizes. The transfer of electrons from the rutile phase to lattice/electron trapping sites of anatase and also to the Ti3+-Vo defect level created by the dopant favors effective charge separation and enhance the photocatalytic activity under solar illumination
Magnetoresistive studies on nanocrystalline La0.8Sr0.2MnO3+delta manganite

Low-temperature magnetoresistance (MR) measurement has been carried out on nanocrystalline La0.8Sr0.2MnO3+delta manganites prepared by combustion synthesis. This preparation method yields voluminous powders with large surface area (similar to 40 m(2)/g) having crystalline nanosize (similar to 50 nm) products. Formation and homogeneity of the solid solutions have been confirmed by powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS). Rietveld refinement of X-ray data indicates that as-formed compound exhibits cubic phase with space group Pm3 m. However, calcined sample transforms into rhombohedral phase with space group R-3c. The stabilization of the cubic phase in as-formed manganite is due to the substitution of Sr2+ on La3+ sites, resulting in higher Mn4+ content. The low-temperature resistivity measurements down to 70 K exhibit a broad metal-insulator transition (TM-I) at around 257 K. MR measurements on sintered pellets show similar to 5% MR at 1 T, whereas for 4 and 7 T, the %MR values are found as 22% and 28%. respectively, at TM-I. (C) 2008 Elsevier B.V. All rights reserved
Measurement of the cross-section for producing a $W$ boson in
  association with a single top quark in $pp$ collisions at $\sqrt{s}={13}$ TeV
  with ATLAS

The inclusive cross-section for the associated production of a $W$ boson and
top quark is measured using data from proton-proton collisions at
$\sqrt{s}={13}$ TeV. The dataset corresponds to an integrated luminosity of 3.2
fb$^{-1}$, and was collected in 2015 by the ATLAS detector at the Large Hadron
Collider at CERN. Events are selected requiring two opposite sign isolated
leptons and at least one jet; they are separated into signal and control
regions based on their jet multiplicity and the number of jets that are
identified as containing $b$ hadrons. The $Wt$ signal is then separated from
the $t\bar{t}$ background using boosted decision tree discriminants in two
regions. The cross-section is extracted by fitting templates to the data
distributions, and is measured to be $94 \pm 10$ (stat.)$^{+28}_{-22}$ (syst.)
$\pm 2$ (lumi.) pb. The measurement is in agreement with the Standard Model
prediction of $\sigma_{\mathrm{theory}} = 71.7 \pm 1.8\,(\mathrm{scale})\,\pm
3.4\,(\mathrm{PDF})\,\mathrm{pb}$.Comment: 40 pages in total, author list starting page 24, 7 figures, 4 tables,
  published in JHEP, All figures including auxiliary figures are available at
  http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/TOPQ-2015-16
Diversity and extracellular enzyme activities of\ud
fungal endophytes isolated from medicinal\ud
plants of Western Ghats, Karnataka

A total of 112 endophytic fungi belonging to 26 genera were isolated from six wild medicinal plants belonging to Bisle region, Western Ghats of Karnataka, among which Hedychium flavescens Carey ex Roscoe and Hedychium coronarium J. Koenig are listed as endangered plants\ud
in the Red data book. The endophytic fungal diversity and extracellular enzyme activity from the endangered plants are reported for the first time. The diversity of the fungal isolates was analyzed using Simpson’s diversity indices, Shannon–Weiner index and Evenness. The fungal isolates were screened for the production of extracellular enzymes, of which 29% were positive for amylase, 28% for cellulase, 18% for pectinase and 40% for asparaginase activity. None of the endophytic isolates depicted laccase activity
Collider signatures of a light NMSSM pseudoscalar in neutralino decays in the light of LHC results.

We investigate signatures induced by a very light pseudoscalar Higgs in neutralino decays in the Next-to-Minimal Supersymmetric Standard Model (NMSSM) and determine their observability at the LHC. We concentrate on scenarios which feature two light scalar Higgs bosons (one of them is SM-like with a mass of 125 GeV and a singlet-like lighter one) with a very light (singlet-like) pseudoscalar Higgs in the mass range 2mτ< ma01ma10 < 2mb. We consider neutralino-chargino pair production and the subsequent decay  χ˜02,3→ χ˜01a01χ~2,30→ χ~10a10 , which leads to topologies involving multi-leptons and missing transverse energy. We determine a set of selection cuts that can effectively isolate the signal from backgrounds of the Standard Model or the Minimal Supersymmetric Standard Model. We also exemplify the procedure with a set of benchmark points, for which we compute the expected number of events and signal strength for LHC with 8 TeV center of mass energy. We show that this signal can already be probed for some points in the NMSSM parameter space
Kinase-dead BRAF and oncongenic RAS cooperate to drive tumour progression through CRAF

Supplemental Information includes Extended Experimental Procedures, four\ud
figures, and three tables and can be found with this article online at doi:\ud
10.1016/j.cell.2009.12.040.We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive RAS-dependent BRAF binding to CRAF, CRAF activation, and MEK–ERK signaling. This does not occur when oncogenic BRAF is inhibited, demonstrating that BRAF inhibition per se does not drive pathway activation; it only occurs when BRAF is inhibited in the presence of oncogenic RAS. Kinase-dead BRAF mimics the effects of the BRAF-selective drugs and kinase-dead Braf and oncogenic Ras cooperate to induce melanoma in mice. Our data reveal another paradigm of BRAF-mediated signaling that promotes tumor progression. They highlight the importance of understanding pathway signaling in clinical practice and of genotyping tumors prior to administering BRAF-selective drugs, to identify patients who are likely to respond and also to identify patients who may experience adverse effects.The Institute of Cancer Research, Cancer Research UK (C107/A10433), and\ud
the Wellcome Trust (080333/Z/06/Z) funded this work. J.S.R.-F. is funded in\ud
part by Breakthrough Breast Cancer. We acknowledge NHS funding to the\ud
NIHR Biomedical Research Centre.Peer-reviewedPublisher Versio
LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

© 2015.Aims/Hypothesis: Glucagon release from pancreatic alpha cells is required for normal glucose homoeostasis and is dysregulated in both Type 1 and Type 2 diabetes. The tumour suppressor LKB1 (STK11) and the downstream kinase AMP-activated protein kinase (AMPK), modulate cellular metabolism and growth, and AMPK is an important target of the anti-hyperglycaemic agent metformin. While LKB1 and AMPK have emerged recently as regulators of beta cell mass and insulin secretion, the role of these enzymes in the control of glucagon production invivo is unclear. Methods: Here, we ablated LKB1 (αLKB1KO), or the catalytic alpha subunits of AMPK (αAMPKdKO, -α1KO, -α2KO), selectively in ~45% of alpha cells in mice by deleting the corresponding floxd alleles with a preproglucagon promoter (. PPG) Cre. Results: Blood glucose levels in male αLKB1KO mice were lower during intraperitoneal glucose, aminoimidazole carboxamide ribonucleotide (AICAR) or arginine tolerance tests, and glucose infusion rates were increased in hypoglycemic clamps (p<0.01). αLKB1KO mice also displayed impaired hypoglycemia-induced glucagon release. Glucose infusion rates were also elevated (p<0.001) in αAMPKα1 null mice, and hypoglycemia-induced plasma glucagon increases tended to be lower (p=0.06). Glucagon secretion from isolated islets was sensitized to the inhibitory action of glucose in αLKB1KO, αAMPKdKO, and -α1KO, but not -α2KO islets. Conclusions/Interpretation: An LKB1-dependent signalling cassette, involving but not restricted to AMPKα1, is required in pancreatic alpha cells for the control of glucagon release by glucose
Evolutionary genomics and conservation of the endangered Przewalski's horse

Przewalski's horses (PHs, Equus ferus ssp. przewalskii) were discovered in the Asian steppes in the 1870s and represent the last remaining true wild horses. PHs became extinct in the wild in the 1960s but survived in captivity, thanks to major conservation efforts. The current population is still endangered, with just 2,109 individuals, one-quarter of which are in Chinese and Mongolian reintroduction reserves [1]. These horses descend from a founding population of 12 wild-caught PHs and possibly up to four domesticated individuals [2-4]. With a stocky build, an erect mane, and stripped and short legs, they are phenotypically and behaviorally distinct from domesticated horses (DHs, Equus caballus). Here, we sequenced the complete genomes of 11 PHs, representing all founding lineages, and five historical specimens dated to 1878-1929 CE, including the Holotype. These were compared to the hitherto-most-extensive genome dataset characterized for horses, comprising 21 new genomes. We found that loci showing the most genetic differentiation with DHs were enriched in genes involved in metabolism, cardiac disorders, muscle contraction, reproduction, behavior, and signaling pathways. We also show that DH and PH populations split ∼45,000 years ago and have remained connected by gene-flow thereafter. Finally, we monitor the genomic impact of ∼110 years of captivity, revealing reduced heterozygosity, increased inbreeding, and variable introgression of domestic alleles, ranging from non-detectable to as much as 31.1%. This, together with the identification of ancestry informative markers and corrections to the International Studbook, establishes a framework for evaluating the persistence of genetic variation in future reintroduced populations
Added value of molecular assay Xpert MTB/RIF compared to sputum smear microscopy to assess the risk of tuberculosis transmission in a low-prevalence country.

Airborne precautions are required at hospital admission for patients with suspected pulmonary tuberculosis. The isolation is maintained until 3 serially collected sputum smears are acid-fast bacilli negative, a time- and labor-intensive method with limited sensitivity and specificity, which has a great impact on patient flow management. We evaluated the possibility of replacing the result of microscopy by the semiquantitative result of the molecular point-of-care test Xpert MTB/RIF to assess patients' transmission risk to quickly guide airborne isolation decisions in low-endemic countries. The performance of the Xpert MTB/RIF, used as a first-line test, was compared to the results of microscopy for specimens (n=242) collected from May 2010 to December 2014 in Lausanne, Switzerland. The sensitivity and specificity of Xpert MTB/RIF were 91.5% (65/71) and 99.6% (170/171), respectively, vs. 64.8% (46/71) and 94.2% (161/171) for microscopy. Samples with negative Xpert MTB/RIF were all smear negative for Mycobacterium tuberculosis (negative predictive value, 100%). The semiquantitative results of Xpert MTB/RIF-high, medium, low or very low-were found to correlate with acid-fast bacilli detection: positive predictive value of 100% (6/6), 96.5% (27/28), 52.2% (12/23) and 11.1% (1/9) respectively. Finally, when including clinical criteria, we identified 11 smear-negative but Xpert MTB/RIF-positive patients with a significant transmission potential. In conclusion, our data support the introduction of an Xpert MTB/RIF-based strategy as a replacement of smear microscopy for a faster and more accurate management of tuberculosis patients' transmission risk in a low-prevalence country
Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia.

Abnormal development can lead to deficits in adult brain function, a trajectory likely underlying adolescent-onset psychiatric conditions such as schizophrenia. Developmental manipulations yielding adult deficits in rodents provide an opportunity to explore mechanisms involved in a delayed emergence of anomalies driven by developmental alterations. Here we assessed whether oxidative stress during presymptomatic stages causes adult anomalies in rats with a neonatal ventral hippocampal lesion, a developmental rodent model useful for schizophrenia research. Juvenile and adolescent treatment with the antioxidant N-acetyl cysteine prevented the reduction of prefrontal parvalbumin interneuron activity observed in this model, as well as electrophysiological and behavioral deficits relevant to schizophrenia. Adolescent treatment with the glutathione peroxidase mimic ebselen also reversed behavioral deficits in this animal model. These findings suggest that presymptomatic oxidative stress yields abnormal adult brain function in a developmentally compromised brain, and highlight redox modulation as a potential target for early intervention
A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire.

Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memory T cells impact the repertoire of T cells responding to new antigens is still largely unknown. We demonstrate that even a minimum epitope overlap between infections strongly increases the activation threshold and narrows the diversity of T cells recruited in response to new antigens. Thus, minimal cross-reactivity between infections can significantly impact the outcome of a subsequent immune response. Interestingly, we found that non-transferrable memory T cells are most effective in raising the activation threshold. Our findings have implications for designing vaccines and suggest that vaccines meant to target low-affinity T cells are less effective when they contain a strong CD8 T cell epitope that has previously been encountered
Jet Vetoes interfering with H → WW

Far off-shell Higgs production in H → WW, ZZ, is a particularly powerful probe of Higgs properties, allowing one to disentangle Higgs width and coupling information unavailable in on-shell rate measurements. These measurements require an understanding of the cross section in the far off-shell region in the presence of realistic experimental cuts. We analytically study the effect of a p [subscript T] jet veto on far off-shell cross sections, including signal-background interference, by utilizing hard functions in the soft collinear effective theory that are differential in the decay products of the W/Z. Summing large logarithms of M[subscript WW] [over p superscript Teto subscript T] , we find that the jet veto induces a strong dependence on M [subscript WW], modifying distributions in M [subscript WW] and M [subscript T]. The example of gg → H → WW is used to demonstrate these effects at next to leading log order. We also discuss the importance of jet vetoes and jet binning for the recent program to extract Higgs couplings and widths from far off-shell cross sections.United States. Dept. of Energy. Office of Science (Office of Nuclear Physics. Grant DE-FG02-94ER40818)Natural Sciences and Engineering Research Council of Canad
Searches for third-generation squark production in fully hadronic final states in proton-proton collisions at √s = 8 TeV

Searches for third-generation squarks in fully hadronic final states are presented using data samples corresponding to integrated luminosities of 19.4 or 19.7 fb[superscript −1], collected at a centre-of-mass energy of 8 TeV with the CMS detector at the LHC. Three mutually exclusive searches are presented, each optimized for a different decay topology. They include a multijet search requiring one fully reconstructed top quark, a dijet search requiring one or two jets originating from b quarks, and a monojet search. No excesses above the standard model expectations are seen, and limits are set on top and bottom squark production in the context of simplified models of supersymmetry.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio