pinecone/core-2020-05-10-deduplication huggingface dataset:
HAMLET forms annular oligomers when deposited with phoshpolipid monolayers

Recently, the anticancer activity of human α-lactalbumin made lethal to
tumor cells (HAMLET) has been linked to its increased membrane affinity in
vitro, at neutral pH, and ability to cause leakage relative to the inactive
native bovine α-lactalbumin (BLA) protein. In this study, atomic force
microscopy resolved membrane distortions and annular oligomers (AOs)
produced by HAMLET when deposited at neutral pH on mica together
with a negatively charged lipid monolayer. BLA, BAMLET (HAMLET's
bovine counterpart) and membrane-binding Peptide C, corresponding to
BLA residues 75–100, also form AO-like structures under these conditions
but at higher subphase concentrations than HAMLET. The N-terminal
Peptide A, which binds to membranes at acidic but not at neutral pH, did
not form AOs. This suggests a correlation between the capacity of the
proteins/peptides to integrate into the membrane at neutralpH—as observed
by liposome content leakage and circular dichroism experiments—and
the formation of AOs, albeit at higher concentrations. Formation of AOs,
which might be important to HAMLET's tumor toxic action, appears
related to the increased tendency of the protein to populate intermediately
folded states compared to the native protein, the formation of which is
promoted by, but not uniquely dependent on, the oleic acid molecules
associated with HAMLET
Sport development programmes for Indigenous Australians : innovation, inclusion and development, or a product of ‘white guilt’?

Under the legacy of neoliberalism, it is important to consider how the indigenous people, in this case of Australia, are to advance, develop and achieve some approximation of parity with broader societies in terms of health, educational outcomes and economic participation. In this paper, we explore the relationships between welfare dependency, individualism, responsibility, rights, liberty and the role of the state in the provision of Government-funded programmes of sport to Indigenous communities. We consider whether such programmes are a product of ‘white guilt’ and therefore encourage dependency and weaken the capacity for independence within communities and individuals, or whether programmes to increase rates of participation in sport are better viewed as good investments to bring about changes in physical activity as (albeit a small) part of a broader social policy aimed at reducing the gaps between Indigenous and non-Indigenous Australians in health, education and employment
Limit on Neutrinoless Double Beta Decay of $^{76}$Ge by GERDA

The Gerda experiment at the Laboratori Nazionali del Gran Sasso in Italy uses germanium detectors made from material with an enriched 76Ge isotope fraction to search for neutrinoless double beta decay of this nucleus. Applying a blind analysis we find no signal after an exposure of 21.6 kg·yr and a background of about 0.01 cts/(keV·kg·yr). A half-life limit of Tov1/2> 2.1 · 1025 yr (90% C.L.) is extracted. The previous claim of a signal for 76Ge is excluded with 99% probability in a model independent way
Search for heavy Majorana neutrinos in mu+mu+[mu-mu-]+jets and e+e+[e-e-]+jets events in pp collisions at sqrt(s) = 7 TeV

A search is performed for heavy Majorana neutrinos (N) using an event signature defined by two same-sign charged leptons of the same flavour and two jets. The data correspond to an integrated luminosity of 4.98 inverse femtobarns of pp collisions at a centre-of-mass energy of 7 TeV collected with the CMS detector at the Large Hadron Collider. No excess of events is observed beyond the expected standard model background and therefore upper limits are set on the square of the mixing parameter, abs(V[ell N]) squared, for ell = e, mu, as a function of heavy Majorana-neutrino mass. These are the first direct upper limits on the heavy Majorana-neutrino mixing for m[N] &gt; 90 GeV
Lax matrix solution of c = 1 conformal field theory

To a correlation function in a two-dimensional conformal field theory with the central charge c = 1, we associate a matrix differential equation Ψ ′ = L Ψ, where the Lax matrix L is a matrix square root of the energy-momentum tensor. Then local conformal symmetry implies that the differential equation is isomonodromic. This provides a justification for the recently observed relation between four-point conformal blocks and solutions of the Painlevé VI equation. This also provides a direct way to compute the three-point function of Runkel-Watts theory — the common c → 1 limit of Minimal Models and Liouville theory
RG flows from (1,0) 6D SCFTs to N = 1 SCFTs in four and three dimensions

We study AdS 5 × Σ 2 and AdS 4 × Σ 3 solutions of N = 2, SO(4) gauged supergravity in seven dimensions with Σ 2,3 being S 2,3 or H 2,3 . The SO(4) gauged supergravity is obtained from coupling three vector multiplets to the pure N = 2, SU(2) gauged supergravity. With a topological mass term for the 3-form field, the SO(4) ∼ SU(2) × SU(2) gauged supergravity admits two supersymmetric AdS 7 critical points, with SO(4) and SO(3) symmetries, provided that the two SU(2) gauge couplings are different. These vacua correspond to N = (1 , 0) superconformal field theories (SCFTs) in six dimensions. In the case of Σ 2 , we find a class of AdS 5 × S 2 and AdS 5 × H 2 solutions preserving eight supercharges and SO(2) × SO(2) symmetry, but only AdS 5 × H 2 solutions exist for SO(2) symmetry. These should correspond to some N = 1 four-dimensional SCFTs. We also give RG flow solutions from the N = (1 , 0) SCFTs in six dimensions to these four-dimensional fixed points including a two-step flow from the SO(4) N = (1 , 0) SCFT to the SO(3) N = (1 , 0) SCFT that eventually flows to the N = 1 SCFT in four dimensions. For AdS 4 × Σ 3 , we find a class of AdS 4 × S 3 and AdS 4 × H 3 solutions with four supercharges, corresponding to N =1 SCFTs in three dimensions. When the two SU(2) gauge couplings are equal, only AdS 4 × H 3 are possible. The uplifted solutions for equal SU(2) gauge couplings to eleven dimensions are also given
Exotic pairing in 1D spin-3/2 atomic gases with SO(4) symmetry

Tuning interactions in the spin singlet and quintet channels of two colliding atoms could change the symmetry of the one-dimensional spin-3/2 fermionic systems of ultracold atoms while preserving the integrability. Here we find a novel SO(4) symmetry integrable point in the spin-3/2 Fermi gas and derive the exact solution of the model using the Bethe ansatz. In contrast to the model with SU(4) and SO(5) symmetries, the present model with SO(4) symmetry preserves spin singlet and quintet Cooper pairs in two sets of SU(2)⊗SU(2) spin subspaces. We obtain full phase diagrams, including the Fulde–Ferrel–Larkin–Ovchinnikov like pair correlations, spin excitations and quantum criticality through the generalized Yang–Yang thermodynamic equations. In particular, various correlation functions are calculated by using finite-size corrections in the frame work of conformal field theory. Moreover, within the local density approximation, we further find that spin singlet and quintet pairs form subtle multiple shell structures in density profiles of the trapped gas
Poisson Lie symmetry and D-branes in WZW model on the Heisenberg Lie group H4

We show that the WZW model on the Heisenberg Lie group H4 has Poisson–Lie symmetry only when the dual Lie group is A2⊕2A1 . In this way, we construct the mutual T-dual sigma models on Drinfel'd double generated by the Heisenberg Lie group H4 and its dual pair, A2⊕2A1 , as the target space in such a way that the original model is the same as the H4 WZW model. Furthermore, we show that the dual model is conformal up to two-loop order. Finally, we discuss D -branes and the worldsheet boundary conditions defined by a gluing matrix on the H4 WZW model. Using the duality map obtained from the canonical transformation description of the Poisson–Lie T-duality transformations for the gluing matrix which locally defines the properties of the D -brane, we find two different cases of the gluing matrices for the WZW model based on the Heisenberg Lie group H4 and its dual model
Corrections and new developments in rigid earth nutation theory. III, Final tables "REN-2000" including crossed-nutation and spin-orbit coupling effects

We present here the new tables REN-2000\ud
of the nutation for a rigid Earth model, starting from\ud
Hamiltonian theory, with a level of truncature at 0:1  as\ud
for individual coe cients instead of 5  as (Kinoshita &\ud
Souchay 1990). For this presentation to be achieved we\ud
 rst carry out the calculations of the second-order effects\ud
due to crossed-nutations and spin-orbit coupling, at\ud
the same level of truncation as above. This paper is the\ud
third and last one in the frame of the complete reconstruction\ud
of the theory of the rigid Earth nutation. It\ud
is the complementary part to previous studies concerning\ud
the luni-solar nutation involving indirect planetary effects\ud
(Souchay & Kinoshita 1996), and the influence of the\ud
second-order geopotential (J3, J4) and of the direct planetary\ud
e ect (Souchay & Kinoshita 1997). Quasi-diurnal\ud
and sub-diurnal nutations coming from the harmonics of\ud
degree 2, 3 and 4 of the geopotential are also included in\ud
REN-2000, their values being taken from Folgueira et al.\ud
(1998a,b). A presentation of the series REN-2000 is done\ud
at the end of the paper, with separated informations for\ud
each contribution.Peer reviewe
ATLAS search for new phenomena in dijet mass and angular distributions using pp collisions at root s=7 TeV

Mass and angular distributions of dijets produced in LHC proton-proton collisions at a centre-of-mass energy root s = 7TeV have been studied with the ATLAS detector using the full 2011 data set with an integrated luminosity of 4.8 fb(-1). Dijet masses up to similar to 4.0TeV have been probed. No resonance-like features have been observed in the dijet mass spectrum, and all angular distributions are consistent with the predictions of QCD. Exclusion limits on six hypotheses of new phenomena have been set at 95% CL in terms of mass or energy scale, as appropriate. These hypotheses include excited quarks below 2.83 TeV, colour octet scalars below 1.86TeV, heavy W bosons below 1.68 TeV, string resonances below 3.61 TeV, quantum black holes with six extra space-time dimensions for quantum gravity scales below 4.11 TeV, and quark contact interactions below a compositeness scale of 7.6 TeV in a destructive interference scenario.<p>ATLAS Collaboration, for complete list of authors see http://dx.doi.org/10.1007/JHEP01(2013)029</p
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at=8 TeV with the ATLAS detector

The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1 fb(-1) of proton-proton collision data at = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via or , where denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of . For a branching fraction of 100%, top squark masses in the range 270-645 GeV are excluded for masses below 30 GeV. For a branching fraction of 50% to either or , and assuming the mass to be twice the mass, top squark masses in the range 250-550 GeV are excluded for masses below 60 GeV.<p>ATLAS Collaboration, for complete list of authors see http://dx.doi.org/10.1007/JHEP09(2014)015</p
Evolutionary dynamics of spliceosomal intron revealed by in silico analyses of the P-Type ATPase superfamily genes.

It has been long debated whether spliceosomal introns originated in the common ancestor of eukaryotes and prokaryotes. In this study, we tested the possibility that extant introns were inherited from the common ancestor of eukaryotes and prokaryotes using in silico simulation. We first identified 21 intron positions that are shared among different families of the P-Type ATPase superfamily, some of which are known to have diverged before the separation of prokaryotes and eukaryotes. Theoretical estimates of the expected number of intron positions shared by different genes suggest that the introns at those 21 positions were inserted independently. There seems to be no intron that arose from before the diversification of the P-Type ATPase superfamily. Namely, the present introns were inserted after the separation of eukaryotes and prokaryotes
Adherence to guidelines and the Screening Tool of Older Persons' potentially inappropriate Prescriptions criteria for colchicine dosing for gout treatment in beneficiaries of the Nova Scotia Seniors' Pharmacare Program Clinical Therapeutics

Purpose: Colchicine is commonly used in the management of gout; however, older persons have higher risks of toxicity. Accordingly, the Screening Tool of Older Person’s potentially inappropriate Prescriptions (STOPP) criteria for colchicine consider 43 months of treatment as potentially inappropriate in older persons. Recent evidence also suggests lower dosing of colchicine is as effective and results in fewer toxicities than high-dose colchicine. The objectives of this study were to determine the dose, duration, and prescribers of colchicine and to evaluate adherence to the STOPP criteria and international guidelines for colchicine in older persons. Methods: A retrospective, observational study was conducted from April 1, 2006 to March 31, 2011 to evaluate colchicine use. Nova Scotia Seniors’ Pharmacare Program beneﬁciaries who met inclusion criteria for an incident case of gout and who ﬁlled at least 1prescription for colchicine during the study period were included. Colchicine dose and duration were reported descriptively. Multivariate logistic regression was used to identify predictors of the study population in making a claim for colchicine 490 and 4180 days. Findings: A total of 518 persons were dispensed 1327 courses of colchicine during the study period. The mean daily dose of colchicine ranged from 1.39 to 1.50 mg. Colchicine doses 41.2 mg were prescribed in approximately one-third of the study population. Colchicine was prescribed for 490 days in 14.2% of treatment courses and for 4180 days in 8.1% of treatment courses. Female sex was the only predictor of treatment duration 490 days. Implications: This study is the ﬁrst to report on colchicine dose and duration using STOPP criteria in a specific cohort of older persons with incident gout. Strategies to improve colchicine prescribing in older persons are needed
The Swift Burst Analyser I. BAT and XRT spectral and flux evolution of gamma ray bursts

Context: Gamma ray burst models predict the broadband spectral evolution and the temporal evolution of the energy flux. In contrast, standard data analysis tools and data repositories provide count-rate data, or use single flux conversion factors for all of the data, neglecting spectral evolution.\ud
\ud
Aims: We produce Swift BAT and XRT light curves in flux units, where the spectral evolution is accounted for.\ud
\ud
Methods: We have developed software to use the hardness ratio information to track spectral evolution of GRBs, and thus to convert the count-rate light curves from the BAT and XRT instruments on Swift into accurate, evolution-aware flux light curves.\ud
\ud
Results: The Swift Burst Analyser website (http://www.swift.ac.uk/burst_analyser) contains BAT, XRT and combined BAT-XRT flux light curves in three energy regimes for all GRBs observed by the Swift satellite. These light curves are automatically built and updated when data become available, are presented in graphical and plain-text format, and are available for download and use in research.Peer-reviewedPublisher Version4412
Enriched lithospheric mantle keel below the Scottish margin of the North Atlantic Craton : evidence from the Palaeoproterozoic Scourie Dyke Swarm and mantle xenoliths.

The Lewisian Gneiss Complex of NW Scotland represents the eastern margin of the North Atlantic Craton. It comprises mid-late Archaean tonalite-trondhjemite-granodiorite gneisses that were metamorphosed and deformed during the Late-Archaean and Palaeoproterozoic. A major swarm of mafic-ultramafic dykes, the Scourie Dyke Swarm, was intruded at ca. 2.4–2.3 Ga during a period of extension that can be correlated across the North Atlantic Craton. The majority of dykes are doleritic, with volumetrically minor picrite and olivine gabbro suites.\ud
\ud
New major and trace element geochemical data and Re-Os isotopes indicate that the Scourie Dyke Swarm was not solely derived from a ‘typical’ asthenospheric mantle source region. The geochemical signatures of the dykes show significant negative Nb, Ta and Ti anomalies, coupled with enrichment in Th, Light Rare Earth Elements and other large ion lithophile elements. These features cannot be reproduced by simple contamination of asthenospheric sources with Lewisian granulite-facies crust. Instead they are a feature of the mantle source that produced the Scourie Dykes and may have developed during Archaean subduction episodes.\ud
\ud
Spinel lherzolite mantle xenoliths from the Isle of Lewis offer direct insight into the lithospheric mantle below this region. They display similar geochemical ‘enrichments’ and ‘depletions’ observed in the Scourie Dykes and the magma source is thus considered to reside primarily in the sub-continental lithospheric mantle (SCLM), with some potential contribution from asthenospheric melts. Platinum Group Element geochemistry and trace element modelling indicate that the dolerite dykes were formed by moderate (<15%) partial melting of the source, whilst higher degrees of partial melting led to the formation of picritic and olivine gabbro suites. Magma production was triggered by significant crustal and lithospheric extension, causing both asthenospheric and substantial lithospheric melting
A Lagrangian for self-dual strings

We propose a Lagrangian for the low-energy theory that resides at the
(1+1)-dimensional intersection of N semi-infinite M2-branes ending orthogonally
on M M5-branes in ${\mathbb R}^{1,2} \times {\mathbb C}^4/{\mathbb Z}_k$ (for
arbitrary positive integers N,M,k). We formulate this theory as a 2d boundary
theory with explicit ${\cal N}=(1,1)$ supersymmetry that contains two
superfields in the bi-fundamental representation of $U(N)\times U(M)$
interacting with the (2+1)-dimensional $U(N)_k\times U(N)_{-k}$ ABJM
Chern-Simons-matter theory in the bulk. We postulate that the boundary theory
exhibits in the deep infrared supersymmetry enhancement to ${\cal N}=(4,2)$, or
${\cal N}=(4,4)$ depending on the value of k. Arguments in favor of the
proposal follow from the study of the open string theory of a U-dual type IIB
Hanany-Witten setup. To formulate the bulk-boundary interactions special care
is taken to incorporate all the expected boundary effects on gauge symmetry,
supersymmetry, and other global symmetries.Comment: 22 pages, 1 figur
$Z_c(3900)$: what has been really seen?

The $Z^\pm_c(3900)/Z^\pm_c(3885)$ resonant structure has been experimentally
observed in the $Y(4260) \to J/\psi \pi\pi$ and $Y(4260) \to \bar{D}^\ast D
\pi$ decays. This structure is intriguing since it is a prominent candidate of
an exotic hadron. Yet, its nature is unclear so far. In this work, we
simultaneously describe the $\bar{D}^\ast D$ and $J/\psi \pi$ invariant mass
distributions in which the $Z_c$ peak is seen using amplitudes with exact
unitarity. Two different scenarios are statistically acceptable, where the
origin of the $Z_c$ state is different. They correspond to using energy
dependent or independent $\bar D^* D$ $S$-wave interaction. In the first one,
the $Z_c$ peak is due to a resonance with a mass around the $D\bar D^*$
threshold. In the second one, the $Z_c$ peak is produced by a virtual state
which must have a hadronic molecular nature. In both cases the two
observations, $Z^\pm_c(3900)$ and $Z^\pm_c(3885)$, are shown to have the same
common origin, and a $\bar D^* D$ bound state solution is not allowed. Precise
measurements of the line shapes around the $D\bar D^*$ threshold are called for
in order to understand the nature of this state.Comment: 6 pages, 6 figure
Interpreting the 750 GeV diphoton excess by the singlet extension of the
  Manohar-Wise Model

The evidence of a new scalar particle $X$ from the 750 GeV diphoton excess,
and the absence of any other signal of new physics at the LHC so far suggest
the existence of new colored scalars, which may be moderately light and thus
can induce sizable $X g g$ and $X \gamma \gamma$ couplings without resorting to
very strong interactions. Motivated by this speculation, we extend the
Manohar-Wise model by adding one gauge singlet scalar field. The resulting
theory then predicts one singlet dominated scalar $\phi$ as well as three kinds
of color-octet scalars, which can mediate through loops the $\phi gg$ and $\phi
\gamma \gamma$ interactions. After fitting the model to the diphoton data at
the LHC, we find that in reasonable parameter regions the excess can be
explained at $1\sigma$ level by the process $ g g \to \phi \to \gamma \gamma$,
and the best points predict the central value of the excess rate with
$\chi_{min}^2=2.32$, which corresponds to a $p$-value of $0.68$. We also
consider the constraints from various LHC Run I signals, and we conclude that,
although these constraints are powerful in excluding the parameter space of the
model, the best points are still experimentally allowed.Comment: 19 pages, 3 figure
Observation of the $\Lambda_b^0\to\Lambda\phi$ decay

The $\Lambda_b^0\to\Lambda\phi$ decay is observed using data corresponding to
an integrated luminosity of 3.0fb$^{-1}$ recorded by the LHCb experiment. The
decay proceeds at leading order via a $b\to s\bar{s}s$ loop transition and is
therefore sensitive to the possible presence of particles beyond the Standard
Model. A first observation is reported with a significance of $5.9$ standard
deviations. The value of the branching fraction is measured to be
$(5.18\pm1.04\pm0.35\,^{+0.67}_{-0.62})\times10^{-6}$, where the first
uncertainty is statistical, the second is systematic, and the third is related
to external inputs. Triple-product asymmetries are measured to be consistent
with zero.Comment: All figures and tables, along with any supplementary material and
  additional information, are available at
  https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-002.html
  - modified to match minor changes in the published version, corrected to add
  additional factor in the ratio of branching fraction