pinecone/core-2020-05-10-deduplication huggingface dataset:
Imaging the spinning gas and dust in the disc around the supergiant A[e] star HD62623

To be published soon in A&AInternational audienceContext. To progress in the understanding of evolution of massive stars one needs to constrain the mass-loss and determine the phenomenon responsible for the ejection of matter an its reorganization in the circumstellar environment Aims. In order to test various mass-ejection processes, we probed the geometry and kinematics of the dust and gas surrounding the A[e] supergiant HD 62623. Methods. We used the combined high spectral and spatial resolution covered by the VLTI/AMBER instrument. Thanks to a new multiwavelength optical/IR interferometry imaging technique, we reconstructed the first velocity-resolved images with a milliarcsecond resolution in the infrared domain. Results. We managed to disentangle the dust and gas emission in the HD 62623 circumstellar disc.We measured the dusty disc inner inner rim, i.e. 6 mas, constrained the inclination angle and the position angle of the major-axis of the disc.We also measured the inner gaseous disc extension (2 mas) and probed its velocity field thanks to AMBER high spectral resolution. We find that the expansion velocity is negligible, and that Keplerian rotation is a favoured velocity field. Such a velocity field is unexpected if fast rotation of the central star alone is the main mechanism of matter ejection. Conclusions. As the star itself seems to rotate below its breakup-up velocity, rotation cannot explain the formation of the dense equatorial disc. Moreover, as the expansion velocity is negligible, radiatively driven wind is also not a suitable explanation to explain the disc formation. Consequently, the most probable hypothesis is that the accumulation of matter in the equatorial plane is due to the presence of the spectroscopic low mass companion
A randomized encoding of the pi-calculus with mixed choice

International audienceWe consider the problem of encoding the pi-calculus with mixed choice into the asynchronous pi-calculus via a uniform translation while preserving a reasonable semantics. Although it has been shown that this is not possible with an exact encoding, we suggest a randomized approach using a probabilistic extension of the asynchronous pi-calculus, and we show that our solution is correct with probability 1 under any proper adversary wrt a notion of testing semantics. This result establishes the basis for a distributed and symmetric implementation of mixed choice which, differently from previous proposals in literature, does not rely on assumptions on the relative speed of processes and it is robust to attacks of proper adversaries
Tracheostomy in patients with long-term mechanical ventilation: a survey.

BACKGROUND:\ud
Tracheostomy is increasingly performed in intensive care units (ICU), with many patients transferred to respiratory ICU (RICU). Indications/timing for closing tracheostomy are discussed.\ud
AIM AND METHOD:\ud
We report results of a one-year survey evaluating: 1) clinical characteristics, types of tracheostomy, complications in patients admitted to Italian RICU in 2006; 2) clinical criteria and systems for performing decannulation, and outcome of patients undergoing tracheostomy (number decannulated; number non-decannulated/non-ventilated; number non-decannulated/ventilated; dead/lost patients).\ud
RESULTS:\ud
22/32 RICUs replied. There were 846 admissions of 719 patients (Mean age 64,3 (+/-14.2) years, 489 (68%) males). Causes of admission were: acute respiratory failure with underlying chronic co-morbidities 176 (24.4%); exacerbation of Chronic Obstructive Pulmonary Disease 222 (34.4%); neuromuscular diseases 200 (27.8%); surgical patients 77 (10.7%); thoracic dysmorphism 28 (3.8%); obstructive sleep apnea syndrome 16 (2.2%). Percutaneous tracheostomies were 65.9%. Major complications after tracheostomy were 2%. 427 tracheostomies were evaluated for decannulation: 96 (22.5%) were closed; 175 patients (41%) were discharged with home mechanical ventilation; 114 patients (26.5%) maintained the tracheostomy despite weaning from mechanical ventilation and 42 patients (10%) died or lost. The clinical criteria chosen for decannulation were: stability of respiratory conditions, effective cough, underlying diseases and ability to swallow. The systems for evaluating feasibility of decannulation were: closure of tracheostomy tube; laryngo-tracheoscopy; use of tracheal button and down-sizing.\ud
CONCLUSIONS:\ud
There were few major complications of tracheostomy. A substantial proportion of patients maintain the tracheostomy despite not requiring mechanical ventilation. There was no agreement on indications and systems for closing tracheostom
Search for a massive resonance decaying into a Higgs boson and a W or Z boson in hadronic final states in proton-proton collisions at sqrt(s) = 8 TeV

A search for a massive resonance decaying into a standard-model-like Higgs boson (H) and a W or Z boson is reported. The analysis is performed on a data sample corresponding to an integrated luminosity of 19.7 fb−1, collected in proton-proton collisions at a centre-of-mass energy of 8 TeV with the CMS detector at the LHC. Signal events, in which the decay products of Higgs, W, or Z bosons at high Lorentz boost are contained within single reconstructed jets, are identified using jet substructure techniques, including the tagging of b hadrons. This is the first search for heavy resonances decaying into HW or HZ resulting in an all-jet final state, as well as the first application of jet substructure techniques to identify H → WW* → 4q decays at high Lorentz boost. No significant signal is observed and limits are set at 95% confidence level on the production cross sections of W′ and Z′ in a model with mass-degenerate charged and neutral spin-1 resonances. Resonance masses are excluded for W′ in the interval [1.0, 1.6] TeV, for Z′ in the intervals [1.0, 1.1] and [1.3, 1.5] TeV, and for mass-degenerate W′ and Z′ in the interval [1.0, 1.7] TeV
Searches for a heavy scalar boson H decaying to a pair of 125 GeV Higgs bosons hh or for a heavy pseudoscalar boson A decaying to Zh, in the final states with h -> tau tau

A search for a heavy scalar boson H decaying into a pair of lighter standard-model-like 125 GeV Higgs bosons hh and a search for a heavy pseudoscalar boson A decaying into a Z and an h boson are presented. The searches are performed on a data set corresponding to an integrated luminosity of 19.7 fb−1 of pp collision data at a centre-of-mass energy of 8 TeV, collected by CMS in 2012. A final state consisting of two τ   leptons and two b jets is used to search for the H→hhH→hh decay. A final state consisting of two τ   leptons from the h boson decay, and two additional leptons from the Z boson decay, is used to search for the decay A→ZhA→Zh. The results are interpreted in the context of two-Higgs-doublet models. No excess is found above the standard model expectation and upper limits are set on the heavy boson production cross sections in the mass ranges 260<mH<350 GeV260<mH<350 GeV and 220<mA<350 GeV220<mA<350 GeV
Intracellular delivery of methylprednisolone by dendrimer-based nanoparticles improves locomotor outcomes after spinal cord injury

Spinal cord injuries (SCI) still remain a major challenge in current biomedical
research. In spite of several advances in the understanding of
its mechanisms there has not been an equal significant translation into
the clinics. As a result, there is no effective treatment that can overcome
the biochemical and cellular adverse reactions that lead to a chronic
severely impaired condition. One of the first opportunities to minimize
these drastic consequences is to control the secondary events that follow
the trauma. We are proposing the local delivery of an anti-inflammatory
corticosteroid - methylprednisolone (MP) – in an attempt to
modulate the noxious effects of the inflammation in the acute SCI. A
sustained delivery as the one provided by these nanoparticles (NP) can
be highly advantageous, maximizing the drug’s potency in the target
site. Therefore, we synthesized MP-loaded NPs composed of an inner
poly/(amido)amine (PAMAM) dendrimeric core and grafted with carboxymethylchitosan
(CMCht). Chemical and biological characterization
studies were carried out showing that the NPs are stable in acidic
and neutral buffer solutions. Also, the viability of primary glial cultures
was not compromised by the presence of 200 lg/mL of NP. In turn, an
MP action in microglial cultures was observed in dosages above 1 mg/
mL showing that MP is being released from the NPs inside the cells.
The uptake profile of these NPs is time dependent and reaches itsmaximum
24 h after incubation with astrocytes, oligodendrocytes and
microglia. In a preview of a possible therapeutic effect, the NPs were
administered in hemisected spinal cord injured rats. To assess the efficacy
of local injections around the lesion site the animals were sacrificed
3 h after surgery and frozen sections were observed. The
fluorescently labeled-NPs were detected in the injury and in the surrounding
spinal tissue indicating a successful delivery of the NP to the
spinal tissue. The local injections were repeated in hemisected rats that
were kept for 1 month, performing the BBB locomotory test weekly.
Significant differences in the BBB test were found between the MPloaded
NPs injected rats and the sham group as well as the ones
injected with MP, demonstrating a favorable action of the MP-NPs in
the acute phase of the injury. This work revealed that sustained delivery
of MP via a NP system can be highly beneficial in the management
of the secondary injury that follows SCI improving the overall functional
outcome of the injured animals
Measurement of χc1 and χc2 production with s√ = 7 TeV pp collisions at ATLAS

The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at TeX = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT and NSRF, Greece; ISF, MIN-ERVA, GIF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW and NCN, Poland; GRICES and FCT, Portugal; MNE/IFA, Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America
Keratin/chitosan as novel grafts for peripheral nerve regeneration

For many years Peripheral Nerve Injuries (PNI) has been raising major concerns in regenerative medicine. Currently, the gold standard treatment for PNI is the autologous nerve grafting but it presents several drawbacks. Chitosan, along with keratin [1], for their good biocompatibility and physicochemical properties have been widely used as biomaterials in tissue engineering scaffolding. Many engineered biomaterials, natural or synthetic, have also been studied, but its poor architecture and lack of appropriate biological cues have been limiting nerve tissue regeneration [2]. In this study, an innovative combination of chitosan and keratin is obtained in order to create a novel nerve conduit (medical device) aimed at finding applications in the treatment of PNI
Search for new physics with jets and missing transverse momentum in pp collisions at √s = 7 TeV

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMJournal of High Energy Physics 2011.8 (2011): 155 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)A search for new physics is presented based on an event signature of at least three jets accompanied by large missing transverse momentum, using a data sample corresponding to an integrated luminosity of 36 pb-1 collected in proton-proton collisions at √s = 7TeV with the CMS detector at the LHC. No excess of events is observed above the expected standard model backgrounds, which are all estimated from the data. Exclusion limits are presented for the constrained minimal supersymmetric extension of the standard model. Cross section limits are also presented using simplified models with new particles decaying to an undetected particle and one or two jet
Investigation of barriers to entry into the design-build market in the People’s Republic of China

Although the design-build (DB) system has been demonstrated to be an effective delivery method and has gained popularity worldwide, it has not gained the same popularity in the construction market of the People’s Republic of China (PRC). The objective of this study was to investigate the barriers to entry in the DB market. A total of 22 entry barriers were first identified through an open-ended questionnaire survey with 15 top construction professionals in the construction market of China. A broad questionnaire survey was further conducted to prioritize these entry barriers. Statistical analysis of responses shows that the most dominant barriers to entry into the DB market are lack of design expertise, lack of interest from owners, lack of suitable organization structure, lack of DB specialists, and lack of credit record system. Analysis of variance indicates that there is no difference of opinions among the respondent groups of academia, government departments, state-owned companies, and private companies, at the 5% significance level, on most of the barriers to entry. Finally, the underlying dimensions of barriers to entry in the DB market were investigated through factor analysis. The results indicate that there are six major underlying dimensions of entry barriers in DB market, including the competence of design-builders, difficulty in project procurement, characteristics of DB projects, lack of support from public sectors, the competence of DB owners, and the immaturity of DB market. These findings are useful for both potential and incumbent design-builders to understand and analyze the DB market in China.Department of Building and Real Estate2011-2012 > Academic research: refereed > Publication in refereed journalpreprint_postprin
Angiogenic mechanims in adipose tissue and tumor

Angiogenesis is involved in the development and progression of many human diseases,
including cancer, cardiovascular diseases, chronic inflammation, and metabolic
diseases. Despite differences in microenvironment under various pathological settings,
angiogenic blood vessels share some common features in numerous diseases. This
thesis reveals novel molecular mechanisms of angiogenesis in tumors and adipose
tissues, as well as defining potential therapeutic targets for treatment of cancer and
obesity-associated metabolic diseases.




In Paper I, we showed that PDGF-BB is a tumor-derived vascular remodeling
factor that promotes tumor growth through activation of stromal fibroblasts and
perivascular cells in tumor microenvironment. Tumor-derived PDGF-BB activates
stromal fibroblasts to produce erythropoietin (Epo), which in turn triggers
extramedullary hematopoiesis thereby enhancing oxygen perfusion in tumor
vasculatures leading to an accelerated tumor growth rate. Epo is also known as a potent
angiogenic factor which acts directly on endothelial cells (ECs) to induce tumor
neovascularization. Therefore, PDGF-BB modulates tumor angiogenesis, vascular
remodeling and hematopoiesis, via activation of the Epo signaling pathway, thus
facilitating tumor growth, invasion and possibly reduces drug responsiveness.
Understanding the role of Epo in promoting tumor growth and angiogenesis not only
provides novel mechanistic insights into the complex interplay between various
signaling pathways involved in the stimulation of angiogenesis, but also highlights the
risk associated with using Epo in treatment of cancer-associated anemia.




In Paper II, we used mouse tumor models to propose a novel mechanism
underlying the combination therapy consisting of anti-angiogenic and
chemotherapeutic agents commonly used in human patients. We showed that tumorderived
VEGF induces severe aplastic anemia in mice, and delivery of
chemotherapeutics to these tumor-bearing mice led to an earlier demise due to the
synergistic or additive suppression of bone marrow hematopoiesis by VEGF and
chemotherapy. Switching to a sequential delivery of anti-angiogenic drugs prior to
administration of chemotherapeutics drugs resulted in significant recovery of bone
marrow hematopoiesis, and thus markedly increased tolerance to chemotoxicity. Given
the fact that a significant number of cancer patients die of chemotoxicity, our findings
provide an important mechanism in which anti-angiogenic drugs decreases
chemotoxicity.





In Paper III, we discuss the novel methods we developed for the study of adipose
angiogenesis, which are becoming increasingly used by other scientists. In Paper IV,
we showed for the first time that cold acclimation of mice markedly activates an
angiogenic phenotype via sympathetic upregulation of VEGF expression. Importantly,
inhibition of angiogenesis significantly modulates adipose metabolism. This work
provides the first example where targeting adipose vasculature might provide a novel
therapeutic approach for the treatment of obesity and metabolic diseases
The return of the nucleus : epigenetic regulation of autophagy

Autophagy is an evolutionary conserved catabolic process activated in response to a variety
of cellular stresses, for example nutrient deprivation or chemotherapy. During autophagy,
cells engulf parts of their cytplasm in a double-membrane vesicle, where misfolded proteins
or damaged organelles are degraded. A plethora of human diseases has been linked to
autophagy, including cancer and neurodegenerative disorders.



Previously, autophagy has been considered a purely cytosolic event as even enucleated cells
were able to display autophagic vesicles. Here we have shown for the first time that
epigenetic changes are a major component of the autophagic process and involve global
changes in the level of several histone modifications and local alterations in DNA
methylation. Autophagy-related epigenetic modifications are involved during all stages of
autophagy and have the potential to influence the autophagic life and death decision.



During the early steps of autophagy, histone modifications are involved in the transcriptional
up-regulation of autophagy-related genes. However, global down-regulation of histone H4
lysine 16 acetylation (H4K16ac) occurring at later stages protects cells from an
overstimulation of autophagy, which can lead to a lethal level of autophagy. Furthermore, we
have uncovered a critical role for the histone H3 lysine 36 (H3K36) demethylase
Rph1/KDM4A in suppressing autophagy under baseline conditions.



As we and others have shown that histone modifications are part of the autophagic process,
we wondered how long the autophagy induced epigenetic modifications remain. By
definition, an epigenetic regulation of autophagy should involve heritable changes that alter
the cellular gene expression for a prolonged period of time.



We indeed found that cancer cells in which autophagy has been induced show a lower
expression of autophagy-related proteins. Upon renewed stimulation these pre-treated cells
show an alteration in autophagic flux compared to untreated cells. This ‘autophagic memory’
involves an early up-regulation of DNA methyl transferase 3A (DNMT3A) which induces a
stable down-regulation of autophagy-related genes by DNA methylation.



In the future, development of new drugs for a variety of diseases involving deregulated
autophagy may benefit from a widened knowledge about the epigenetic autophagy-regulatory
network
N-quantum approach to quantum field theory at finite T and mu: the NJL model

We extend the N-quantum approach to quantum field theory to finite temperature (T) and chemical potential (μ) and apply it to the NJL model. In this approach the Heisenberg fields are expressed using the Haag expansion while temperature and chemical potential are introduced simultaneously through a generalized Bogoliubov transformation. Known mean field results are recovered using only the first term in the Haag expansion. In addition, we find that at finite T and in the broken symmetry phase of the model the mean field approximation can not diagonalize the Hamiltonian. Inclusion of scalar and axial vector diquark channels in the SU(2)rmf otimes SU(3)c version of the model can lead to a lowering of the vacuum energy density. We discuss how to go beyond the mean field approximation by including higher order terms in the Haag expansion
Symmetric Gauss Legendre quadrature formulas for composite numerical integration over a triangular surface

This paper first presents a Gauss Legendre quadrature method for numerical integration of View the MathML source, where f(x, y) is an analytic function in x, y and T is the standard triangular surface: {(x, y)∣0 ⩽ x, y ⩽ 1, x + y ⩽ 1} in the Cartesian two dimensional (x, y) space. We then use a transformation x = x(ξ, η), y = y(ξ, η  ) to change the integral I to an equivalent integral View the MathML source, where S is now the 2-square in (ξ, η) space: {(ξ, η)∣ − 1 ⩽ ξ, η ⩽ 1}. We then apply the one dimensional Gauss Legendre quadrature rules in ξ and η variables to arrive at an efficient quadrature rule with new weight coefficients and new sampling points. We then propose the discretisation of the standard triangular surface T into n2 right isosceles triangular surfaces Ti (i = 1(1)n2) each of which has an area equal to 1/(2n2) units. We have again shown that the use of affine transformation over each Ti and the use of linearity property of integrals lead to the result:\ud
\ud
View the MathML source\ud
Turn MathJax on\ud
\ud
where View the MathML source and x = xi(X, Y) and y = yi(X, Y) refer to affine transformations which map each Ti in (x, y) space into a standard triangular surface T in (X, Y) space. We can now apply Gauss Legendre quadrature formulas which are derived earlier for I   to evaluate the integral View the MathML source. We observe that the above procedure which clearly amounts to Composite Numerical Integration over T   and it converges to the exact value of the integral View the MathML source, for sufficiently large value of n, even for the lower order Gauss Legendre quadrature rules. We have demonstrated this aspect by applying the above explained Composite Numerical Integration method to some typical integrals