pinecone/core-2020-05-10-deduplication huggingface dataset:
Dryland, calcareous soils store (and lose) significant quantities of near-surface organic carbon

PublishedSemiarid ecosystems are susceptible to changes in dominant vegetation which may have significant implications for terrestrial carbon dynamics. The present study examines the distribution of organic carbon (OC) between particle size fractions in near-surface (0–0.05 m) soil and the water erosion-induced redistribution of particle-associated OC over a grass-shrub ecotone, in a semiarid landscape, subject to land degradation. Coarse (>2 mm) particles have comparable average OC concentrations to the fine (<2 mm) particles, accounting for ~24–38% of the OC stock in the near-surface soil. This may be due to aggregate stabilization by precipitated calcium carbonate in these calcareous arid soils. Critically, standard protocols assuming that coarse fraction particles contain no OC are likely to underestimate soil OC stocks substantially, especially in soils with strongly stabilized aggregates. Sediment eroded from four hillslope scale (10 × 30 m) sites during rainstorm events was monitored over four annual monsoon seasons. Eroded sediment was significantly enriched in OC; enrichment increased significantly across the grass-shrub ecotone and appears to be an enduring phenomenon probably sustained through the dynamic replacement of preferentially removed organic matter. The average erosion-induced OC event yield increased sixfold across the ecotone from grass-dominated to shrub-dominated ecosystems, due to both greater erosion and greater OC enrichment. This erosional pathway is rarely considered when comparing the carbon budgets of grasslands and shrublands, yet this accelerated efflux of OC may be important for long-term carbon storage potentials of dryland ecosystems.This research was conducted while A.M.
Cunliffe was in receipt of a NERC
Doctoral Training grant (NE/K500902/1)
and was supported by the NSF Long
Term Ecological Research Program at
the Sevilleta National Wildlife Refuge
(DEB-1232294) This research was conducted
while A.M.C. was in receipt of a
NERC Doctoral Training grant (NE/
K500902/1) and was supported by the
NSF Long Term Ecological Research
Program at the Sevilleta National
Wildlife Refuge (DEB-1232294). L.T. was
supported by travel bursaries from the
University of Sheffield, the Worshipful
Company of Farmers, and the Royal
Society Dudley Stamp Memorial Fund
Award. We are
grateful to John Buffington, Jon
Pelletier, and two anonymous reviews
whose suggestions greatly improved
upon earlier versions of this paper
Coupled subdaily and multiweek cycles during the lava dome erupt of Soufriere Hills Volcano, Montserrat

Observations of volcanoes extruding andesitic lava to produce lava domes often reveal cyclic behaviour. At Soufriere Hills Volcano, Montserrat, cycles with sub-daily and multi-week periods have been recognised on many occasions. These two types of cycle have been modelled separately as stick-slip magma flow at the junction between a dyke and an overlying cylindrical conduit (Costa et al. 2012), and as the filling and discharge of magma through the elastic-walled dyke (Costa et al., 2007a) respectively. Here, we couple these two models to simulate the behaviour over a period of well-observed multi-week cycles, with accompanying sub-daily cycles, from 13 May to 21 September 1997. The coupled model captures well the asymmetrical first-order behaviour: the first 40% of the multi-week cycle consists of high rates of lava extrusion during short period/high amplitude sub-daily cycles as the dyke reservoir discharges itself. The remainder of the cycle involves increasing pressurization as more magma is stored, and extrusion rate falls, followed by a gradual increase in the period of the sub-daily cycles
Characteristics of a Graphene Nanoplatelet Anode in Advanced Lithium-Ion Batteries Using Ionic Liquid Added by a Carbonate Electrolyte

A Cu-supported, graphene nanoplatelet (GNP) electrodes are reported a as high performance anode in lithium ion battery. The electrode precursor is an easy-to-handle aqueous ink cast on cupper foil and following dried in air. The scanning electron microscopy evidences homogeneous, micrometric flakes-like morphology. Electrochemical tests in conventional electrolyte reveal a capacity of about 450 mAh g<sup>-1</sup> over 300 cycles, delivered at a current rate as high as 740 mA g<sup>-1</sup>. The graphene-based electrode is characterized using a N-butyl-N-methyl-pyrrolidiniumbis (trifluoromethanesulfonyl) imide, lithium-bis(trifluoromethanesulfonyl)imide (Py<inf>1,4</inf>TFSI-LiTFSI) ionic liquid-based solution added by ethylene carbonate (EC): dimethyl carbonate (DMC). The Li-electrolyte interface is investigated by galvanostatic and potentiostatic techniques as well as by electrochemical impedance spectroscopy, in order to allow the use of the graphene-nanoplatelets as anode in advanced lithium-ion battery. Indeed, the electrode is coupled with a LiFePO<inf>4</inf> cathode in a battery having a relevant safety content, due to the ionic liquid-based electrolyte that is characterized by an ionic conductivity of the order of 10<sup>-2</sup> S cm<sup>-1</sup>, a transference number of 0.38 and a high electrochemical stability. The lithium ion battery delivers a capacity of the order of 150 mAh g<sup>-1</sup> with an efficiency approaching 100%, thus suggesting the suitability of GNPs anode for application in advanced configuration energy storage systems
Triple negative breast cancer: nanosolutions for a big challenge

Triple negative breast cancer (TNBC) is a particular immunopathological subtype of breast cancer that lacks expression of estrogen and progesterone receptors (ER/PR) and amplification of the human epidermal growth factor receptor 2 (HER2) gene. Characterized by aggressive and metastatic phenotypes and high rates of relapse, TNBC is the only breast cancer subgroup still lacking effective therapeutic options, thus presenting the worst prognosis. The development of targeted therapies, as well as early diagnosis methods, is vital to ensure an adequate and timely therapeutic intervention in patients with TNBC. This review intends to discuss potentially emerging approaches for the diagnosis and treatment of TNBC patients, with a special focus on nano-based solutions that actively target these particular tumors.his study was supported by the Portuguese Foundation for Science and Technology (FCT) and the European Community fund FEDER, through Program COMPETE, under the scope of the Projects FCOMP01–0124-FEDER -0 21053 (PTDC/ SAU-BMA/121028/2010), PEst-OE/ EQB/LA0023/2013, RECI/BBB-EBI/0179/2012 (FCOMP-01–0124FEDER-027462), the strategic funding of UID/BIO/04469/2013 unit, and the Projects “BioHealth – Biotechnology and Bioengineering approaches to improve health quality”, REF. NORTE-07–0124-FEDER-000027, and “BioInd – Biotechnology and Bioengineering for improved Industrial and Agro-Food processes”, REF. NORTE-07–0124-FEDER-000028, co-funded by the Programa Operacional Regional do Norte (ON.2 – O Novo Norte), QREN, FEDER. Tânia Mendes acknowledges the FCT for supporting her PhD grant (SFRH / BD / 51955 / 2012)
Injection Length in Staggered Organic Thin Film Transistors: Assessment and Implications for Device Downscaling

In staggered thin film transistors, the injection length is the fraction of the gate to contact overlap that is effectively involved in current injection. Its assessment is important to properly downscale device dimensions. In fact, in order to increase transistor operation speed, the whole device footprint should be downscaled, which means both the gate to contact overlap and the channel length, as they affect the relative weight of gate to contact parasitic capacitances and the carrier transit time along the channel respectively. Nevertheless, it is not advisable to make the gate to contact overlap smaller than the injection length, because this negatively affects contact resistances. Suitable figures of merits are introduced to quantify these aspects, and a method is proposed to extract the injection length from electrical measurements. As an example of application, transistors based on the prototypical n-type polymer poly[N,N′-bis(2-octyldodecyl)-naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,5′-(2,2′-bithiophene) (P(NDI2OD-T2) are analyzed. When the channel length is scaled while driving voltages are kept constant, in P(NDI2OD-T2) the injection length decreases as well, thus proving that the downscaling of the whole device footprint is feasible. The physical origins of this finding are analyzed and traced back to material properties, in order to suggest general guidelines for a successful transistor downscaling
Basic theory behind parameterizing atmospheric convection

Last fall, a network of the European Cooperation in Science and Technology (COST), called “Basic Concepts for Convection Parameterization in Weather Forecast and Climate Models” (COST Action ES0905; see http://w3.cost.esf.org/index.php?id=205&action_number=ES0905), organized a 10-day training course on atmospheric convection and its parameterization. The aim of the workshop, held on the island of Brac, Croatia, was to help young scientists develop an in-depth understanding of the core theory underpinning convection parameterizations. The speakers also sought to impart an appreciation of the various approximations, compromises, and ansatz necessary to translate theory into operational practice for numerical models
Contribution of ultrarare variants in mTOR pathway genes to sporadic focal epilepsies

Objective: We investigated the contribution to sporadic focal epilepsies (FE) of ultrarare variants in genes coding for the components of complexes regulating mechanistic Target Of Rapamycin (mTOR)complex 1 (mTORC1). Methods: We collected genetic data of 121 Italian isolated FE cases and 512 controls by Whole Exome Sequencing (WES) and single-molecule Molecular Inversion Probes (smMIPs) targeting 10 genes of the GATOR1, GATOR2, and TSC complexes. We collapsed “qualifying” variants (ultrarare and predicted to be deleterious or loss of function) across the examined genes and sought to identify their enrichment in cases compared to controls. Results: We found eight qualifying variants in cases and nine in controls, demonstrating enrichment in FE patients (P = 0.006; exact unconditional test, one-tailed). Pathogenic variants were identified in DEPDC5 and TSC2, both major genes for Mendelian FE syndromes. Interpretation: Our findings support the contribution of ultrarare variants in genes in the mTOR pathway complexes GATOR and TSC to the risk of sporadic FE and a shared genetic basis between rare and common epilepsies. The identification of a monogenic etiology in isolated cases, most typically encountered in clinical practice, may offer to a broader community of patients the perspective of precision therapies directed by the underlying genetic cause
National Scientific Performance Evolution Patterns: Retrenchment, Successful Expansion, or Overextension

National governments would like to preside over an expanding and increasingly high impact science system but are these two goals largely independent or closely linked? This article investigates the relationship between changes in the share of the world’s scientific output and changes in relative citation impact for 2.6 million articles from 26 fields in the 25 countries with the most Scopus-indexed journal articles from 1996 to 2015. There is a negative correlation between expansion and relative citation impact but their relationship varies. China, Spain, Australia, and Poland were successful overall across the 26 fields, expanding both their share of the world’s output and its relative citation impact, whereas Japan, France, Sweden and Israel had decreased shares and relative citation impact. In contrast, the USA, UK, Germany, Italy, Russia, Netherlands, Switzerland, Finland, and Denmark all enjoyed increased relative citation impact despite a declining share of publications. Finally, India, South Korea, Brazil, Taiwan, and Turkey all experienced sustained expansion but a recent fall in relative citation impact. These results may partly reflect changes in the coverage of Scopus and the selection of fields
Care pathways in the transition of patients between district psychiatric hospital centres (DPCs) and community mental health services

Rationale, aims, and objectives: Patients with mental health problems experience numerous transitions into and out of the hospital. Primary care providers have mixed success in identifying and managing patients' needs. This study explores health personnel’s experience of care pathways in patient transition between inpatient and community mental health services.\ud
Method: A descriptive qualitative design was chosen. Four focus group interviews with twelve informants from seven different communities were conducted. Interviews were analyzed thematically. \ud
Results: Two main themes were identified: integrated care and patient activation. The participants shared their experiences on topics that can affect smooth care pathways in mental health. Six promoting factors were identified for successful patient transition: opportunities for information sharing, implementation of systematic plans, use of e-messages, around-the-clock care, designating one responsible health person in each system for each patient, and the involvement of patients and their families. The following barriers were all found to impede the patients’ transition between levels of care: the lack of a single responsible person at each health care level, insufficient meetings, the absence of systematic plans, difficulties in identifying the right staff at different levels, delays in information sharing, and the complexity of welfare systems negatively affecting patient dignity. \ud
Conclusions: Systems and procedures should be developed to ensure clear responsibilities and transparency at each stage of the pathways of care. A single person should take charge of ensuring sufficient connection and communication between inpatient and community mental health services. Finally, both patient and staff in community services should be linked through a direct telephone number with around-the-clock availability
Does influence beget autonomy? Clarifying the relationship between social and personal power

We iteratively develop and test a model to clarify the relationship between both high and low levels of social (influence) and personal (autonomy) power. A meta-analysis synthesising primary data (n = 298) and secondary data (n = 498) found that impaired personal power coincided with impaired social power, but not vice versa. Unexpectedly, elevated social power did not coincide with elevated personal power, suggesting that the association between influence and autonomy attenuates with increasing levels of power. Predictions arising from the meta-analysis and our revised theoretical model were supported in a subsequent study (n = 266). We discuss implications of these findings and avenues for future research
Developmental components of resting ventilation among high- and low-altitude Andean children and adults

This paper evaluates the age-associated changes of resting ventilation of 115 high- and low-altitude Aymara subjects, of whom 61 were from the rural Aymara village of Ventilla situated at an average altitude of 4,200 m and 54 from the rural village of Caranavi situated at an average altitude of 900 m. Comparison of the age patterns of resting ventilation suggests the following conclusions: 1) the resting ventilation (ml/kg/min) of high-altitude natives is markedly higher than that of low-altitude natives; 2) the age decline of ventilation is similar in both lowlanders and highlanders, but the starting point and therefore the age decline are much higher at high altitude; 3) the resting ventilation that characterizes high-altitude Andean natives is developmentally expressed in the same manner as it is at low altitude; and 4) the resting ventilation (ml/kg/min) of Aymara high-altitude natives is between 40–80% lower than that of Tibetans. Am J Phys Anthropol 109:295–301, 1999. © 1999 Wiley-Liss, Inc
High prevalence of hepatitis C virus infection in patients with B-cell lymphoproliferative disorders in Italy.

Starting from the observation that a number of consecutive patients with non-Hodgkin's lymphoma (NHL) resulted positive for hepatitis C virus (HCV) antibodies on routine testing, we set up a survey for HCV contact prevalence in all patients with lymphoproliferative disorders (LPD) followed in our institution. We searched for HCV antibodies by a thirdgeneration ELISA technique, followed by a confirmation test (RIBA III); serum viral RNA and HCV genotype were investigated by a RT-PCR technique. We screened a total of 315 patients suffering from B-NHL (91), multiple myeloma (56), MGUS (48), chronic lymphocytic leukemia (57), Waldentrom's macroglobulinemia (13), Hodgkin's disease (HD)(43), and T-NHL (9). While only I of 52 patients with a non-B-LPD (HD or T-NHL) had signs of HCV contact (i.e., 1.9%, which is in the range of the normal population in the South of Italy), 59 of 263 patients with a B-LPD (22.4%) had HCV antibodies or RNA, or both, with no major differences among the various types of disorders, except for WM, in which the rate was higher (61.5%). The same prevalence was found for patients tested at diagnosis or during the follow-up, and in transfused or never-transfused patients. Only a few patients were aware of having a liver disease; one-half of HCV-positive patients never had transaminase increase. A review of data from Central and Northern Italy is included, showing similar findings; a report from Japan has confirmed such an association, while limited surveys in England have not revealed any correlation. These findings may have important biological and clinical implications
Effects of low molecular weight heparin, alone or combined with antithrombin III, on mortality, fibrin deposits and hemostatic parameters in endotoxin-induced disseminated intravascular coagulation in rabbits

The effect of low molecular weight heparin (LMWH) with or without antithrombin III (AT III) has been studied in a rabbit model of disseminated intravascular coagulation (DIC) induced by continuous infusion of 100 microg/kg/hr of Escherichia coli endotoxin for 6 hr. LMWH (5 and 10 IU/kg/hr/6 hr), alone or in combination with AT III (20 U/kg/hr/6 hr), or saline were administered simultaneously with endotoxin. Hemostatic markers at 0, 2, and 6 hr as well as kidney fibrin deposits and the mortality rate at 24 hr were determined. Rabbits receiving only endotoxin showed an impairment in hemostasis, as well as high kidney fibrin deposits and a high mortality rate. LMWH alone did not exert any effect. The simultaneous infusion of LMWH and AT III exerted a beneficial effect on the hemostatic markers and reduced the kidney fibrin deposits as well as the mortality rate in a LMWH dose-dependent manner. Fibrinogen and protein C consumption were significantly higher and renal fibrin deposits more intense in the rabbits that had died in the first 24 hr. There was also a significant positive correlation between kidney fibrin deposits and platelets, fibrinogen, and protein C consumption, taking the whole rabbit population. It is concluded that the simultaneous infusion of LMWH and AT III is useful in this DIC model and would make it possible to reduce significantly the AT III doses used when AT III is given alone
Recombinant Human Erythropoietin for the Treatment of Anemia in Children With Solid Malignant Tumors

Cancer is often associated with chronic anemia which frequently requires blood transfusions. This study was performed to assess the efficacy and safety of r-HuEPO therapy in children with cancer.

PATIENTS AND METHODS: Twenty-five patients under 18 years of age with solid malignant tumors were treated with 150 U/kg/day of r-HuEPO 5 times weekly for 12 weeks. Response was defined as an increase of the baseline hemoglobin level by at least 2 g/dl. r-HuEPO patients were compared to 25 matched historical controls.

RESULTS: Response was achieved in 72% of r-HuEPO patients. Hemoglobin level increased from 9.8 +/- 0.6 g/dl at baseline to 12.4 +/- 1.7 g/dl at the end of treatment in the r-HuEPO group and increased from 9.5 +/- 0.7 g/dl to 9.6 +/- 1.4 g/dl in the control group (P < .001, Student's t-test). Only 16% of patients receiving r-HuEPO required blood transfusions vs 96% of control patients (P < .001, Student's t-test), with mean units of blood transfused per patient being 0.35 in the r-HuEPO group and 3.56 in controls (P < .001, Student's t-test). There was a statistically significance improvement in Karnofsky's index in r-HuEPO patients. No adverse reaction related to r-HuEPO therapy was observed.

CONCLUSIONS: r-HuEPO is a safe and effective means of increasing hemoglobin level and reducing blood requirements in children with solid malignant tumors receiving chemotherapy
Emergence of Secondary Acute Leukemia in a Patient Treated for Osteosarcoma: Implications of Germline TP53 Mutations

Secondary leukemia and myelodysplastic syndromes have been reported
      in patients following treatment for a wide range of neoplastic disorders. However
      second malignancies after chemotherapy and/or irradiation for osteosarcoma are
      unusual. PROCEDURE: We report the case of a 15-year-old girl who developed a
      myelodysplastic syndrome with evolution to acute nonlymphocytic leukemia after
      treatment for osteosarcoma. Therapy-related acute leukemia karyotype findings
      such as abnormalities of chromosomes 5, 7, and 17 were found in the cytogenetic
      analysis. Moreover, using denaturing gradient gel electrophoresis and DNA
      sequencing, we detected the presence of a double germline mutation in exon 7 of
      the TP53 gene. CONCLUSION: This observation supports the possibility of a causal 
      relationship between germline TP53 mutations and the development of secondary
      leukemia and myelodysplasi