pinecone/core-2020-05-10-deduplication huggingface dataset:
Left Ventricular Rotational Mechanics in Tanzanian Children with Sickle Cell Disease.

Sickle cell disease (SCD) is a common inherited hemoglobinopathy. Adults with SCD manifest both systolic and diastolic cardiac dysfunction, though the age of onset of dysfunction has not been defined. Left ventricular (LV) rotational mechanics have not been studied in children with SCD. The aim of this study was to investigate whether cardiac rotational mechanics differed between children with SCD and age-matched controls. Basal and apical LV short-axis images were acquired prospectively in 213 patients with SCD (mean age, 14.1 ± 2.6 years) and 49 controls (mean age, 13.3 ± 2.8 years) from the Muhimbili Sickle Cohort in Dar es Salaam, Tanzania. The magnitude of basal and apical rotation, net twist angle, torsion, and untwist rate were obtained by two-dimensional speckle-tracking. The timing of events was normalized to aortic valve closure. Mean basal rotation was significantly lower in patients with SCD compared with controls (P = .012), although no difference was observed in apical rotation (P = .37). No statistically significant differences in torsion or net twist angle were detected. Rotation rate at the apex (P = .001) and base (P = .0004) were significantly slower in subjects with SCD compared with controls. Mean peak untwisting rate was also significantly slower in patients with SCD (P = .006). No associations were found between hemoglobin concentration and apical rotation, basal rotation, net twist, and torsion. This study demonstrates alterations in LV rotational mechanics in children with SCD, including lower basal rotation, peak differential twist, and untwist rate. These abnormalities denote subclinical changes in LV systolic and diastolic performance in children with SCD. Future work may reveal an association between rotational metrics and long-term patient outcomes
The Oldham Notebooks: an analysis of the development of IVF 1969-1978. II. The treatment cycles and their outcomes

This paper reports on the numbers of treatment cycles involved and their outcomes. We show that between 1969 and 1978 (i) a minimum of 282 women was involved in 495 cycles of potential laparoscopic oocyte recovery (LOR), (ii) of these cycles, 457/495 proceeded to LOR to attempt egg collection, (iii) of which an outcome was recorded in 436/457, (iv) eggs were recovered in 388/436 of these, (v) inseminations were recorded in 331/388, (vi) embryos were recorded in at least 167, (vii) a total of 112 embryo transfers was attempted, and (viii) a maximum of 11 possible biochemical/preclinical pregnancies plus five clinical pregnancies was observed, (ix) from which two healthy live births resulted.The research was supported by grants from the Wellcome Trust (088708 and 094985), which otherwise had no involvement in the research or its publication.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.rbms.2015.04.00
Microtubule-Associated Protein 3 Regulates IP3 Receptor Clustering and Ca^2+ Signaling in Endothelial Cells

The mechanisms by which microtubule cytoskeleton regulates the permeability of endothelial barrier are not well understood. Here we demonstrate that microtubule-associated end-binding protein 3 (EB3), a core component of the microtubule plus-end protein complex, binds to inositol 1,4,5-trisphosphate receptors (IP3Rs) through a S/TxIP EB-binding motif. In endothelial cells, α-thrombin, a pro-inflammatory mediator which stimulates phospholipase Cβ, increases the cytosolic Ca^2+ concentration and elicits clustering of IP3R3s. These responses, and the resulting Ca^2+-dependent phosphorylation of myosin light chain, are prevented by depletion of either EB3 or mutation of TxIP motif of IP3R3 responsible for mediating its binding to EB3. We also show that selective EB3 gene deletion in endothelial cells of mice abrogates α-thrombin-induced increase in endothelial permeability. We conclude that the EB3-mediated interaction of IP3Rs with microtubules controls the assembly of IP3Rs into effective Ca^2+ signaling clusters, which thereby regulate microtubule-dependent endothelial permeability.Supported by NIH grants R01 HL103922 and Giles F. Filley Memorial Award to Y.A.K.; 
PO1 HL60678 to A.B.M; T32 HL07829-17 and AHA AWARD 13PRE17090090 to M. G. and a Wellcome Trust Senior Investigator Award (101844) to C.W.T.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.celrep.2015.06.00
Measurement of the differential dijet production cross section in proton–proton collisions at √s = 7 TeV

A measurement of the double-differential inclusive dijet production cross section in proton–proton collisions at √s = 7 TeV is presented as a function of the dijet invariant mass and jet rapidity. The data correspond to an integrated luminosity of 36 pb[superscript −1], recorded with the CMS detector at the LHC. The measurement covers the dijet mass range 0.2 TeV to 3.5 TeV and jet rapidities up to |y|=2.5. It is found to be in good agreement with next-to-leading-order QCD predictions.United States. Dept. of EnergyNational Science Foundation (U.S.
Trace decategorification of categorified quantum $\mathfrak {sl}_2$

The trace or the 0th Hochschild–Mitchell homology of a linear category $\mathcal{C}$ may be regardedas a kind of decategorification of $\mathcal{C}$. We compute the traces of the two versions $\mathcal{U}$ and $\mathcal{U^*}$ of categorified quantum $\mathrm{U}(\mathfrak{sl}_2)$ introduced by the third author. The trace of $\mathcal{U}$ is isomorphic to the split Grothendieck group $\mathit{K}_0(\mathcal{U})$, and the higher Hochschild–Mitchell homology of $\mathcal{U}$ is zero. The trace of $\mathcal{U^*}$ is isomorphic to the idempotented integral form of the current algebra $\mathrm{U}(\mathfrak{sl}_2[\mathit{t}])$
Application of Humic Sorbents for Pb{2+}, Cu{2+} and Hg{2+} Ions Preconcentration from Aqueous Solutions

The sorbent prepared by sequential treatment of silica gel by polyhexamethylene guanidine of linear structure and humic acids is suggested for sorption concentration of metal ions (Pb{2+}, Cu{2+} and Hg{2+}) from aqueous solutions. Thermogravimetry and infrared spectroscopy have confirmed the success of the attachment of the humic acids onto modified silica surface. Sorption isotherms of lead (II), copper (II) and mercury (II) obtained in optimal conditions of metals sorption were analyzed by using Freundlich and Langmuir adsorption isotherms. Structural model of surface of humic sorbent was proposed based on the obtained results. The results demonstrated the potential applicability of supramolecular humic sorbent in the preconcentration of metal ions from aqueous solution
Hadronization scheme dependence of long-range azimuthal harmonics in high energy p + A reactions

AbstractWe compare the distortion effects of three popular final-state hadronization schemes. We show how hadronization modifies the initial-state gluon correlations in high energy p + A collisions. The three models considered are (1) LPH: local parton–hadron duality, (2) CPR: collinear parton–hadron resonance independent fragmentation, and (3) LUND: color string hadronization. The strong initial-state azimuthal asymmetries are generated using the GLVB model for non-abelian gluon bremsstrahlung, assuming a saturation scale Qsat=2 GeV. Long-range elliptic and triangular harmonics for the final hadron pairs are compared based on the three hadronization schemes. Our analysis shows that the process of hadronization causes major distortions of the partonic azimuthal harmonics for transverse momenta at least up to pT=3 GeV. In particular, they appear to be greatly reduced for pT<1÷2 GeV
Transparency ratio in γA→η′A′ and the in-medium η′ width

AbstractThe photoproduction of η′-mesons off different nuclei has been measured with the CBELSA/TAPS detector system for incident photon energies between 1500–2200 MeV. The transparency ratio has been deduced and compared to theoretical calculations describing the propagation of η′-mesons in nuclei. The comparison indicates a width of the η′-meson of the order of Γ=15–25 MeV at ρ=ρ0 for an average momentum pη′=1050 MeV/c, at which the η′-meson is produced in the nuclear rest frame. The inelastic η′N cross section is estimated to be 3–10 mb. Parameterizing the photoproduction cross section of η′-mesons by σ(A)=σ0Aα, a value of α=0.84±0.03 has been deduced
Chemical and genomic evolution of enzyme-catalyzed reaction networks

AbstractThere is a tendency that a unit of enzyme genes in an operon-like structure in the prokaryotic genome encodes enzymes that catalyze a series of consecutive reactions in a metabolic pathway. Our recent analysis shows that this and other genomic units correspond to chemical units reflecting chemical logic of organic reactions. From all known metabolic pathways in the KEGG database we identified chemical units, called reaction modules, as the conserved sequences of chemical structure transformation patterns of small molecules. The extracted patterns suggest co-evolution of genomic units and chemical units. While the core of the metabolic network may have evolved with mechanisms involving individual enzymes and reactions, its extension may have been driven by modular units of enzymes and reactions
Hanbury–Brown–Twiss measurements at large rapidity separations, or can we measure the proton radius in p-A collisions?

AbstractWe point out that current calculations of inclusive two-particle correlations in p-A collisions based on the Color Glass Condensate approach exhibit a contribution from Hanbury–Brown–Twiss correlations. These HBT correlations are quite distinct from the standard ones, in that they are apparent for particles widely separated in rapidity. The transverse size of the emitter which is reflected in these correlations is the gluonic size of the proton. This raises an interesting possibility of measuring the proton size directly by the HBT effect of particle pairs produced in p-A collisions
Cluster Analysis of Diffusion Tensor Fields with Application to the Segmentation of the Corpus Callosum

AbstractAccurate segmentation of the Corpus Callosum (CC) is an important aspect of clinical medicine and is used in the diagnosis of various brain disorders. In this paper, we propose an automated method for two and three dimensional segmentation of the CC using diffusion tensor imaging. It has been demonstrated that Hartigan's K-means is more efficient than the traditional Lloyd algorithm for clustering. We adapt Hartigan's K-means to be applicable for use with the metrics that have a f -mean (e.g. Cholesky, root Euclidean and log Euclidean). Then we applied the adapted Hartigan's K-means, using Euclidean, Cholesky, root Euclidean and log Euclidean metrics along with Procrustes and Riemannian metrics (which need numerical solutions for mean computation), to diffusion tensor images of the brain to provide a segmentation of the CC. The log Euclidean and Riemannian metrics provide more accurate segmentations of the CC than the other metrics as they present the least variation of the shape and size of the tensors in the CC for 2D segmentation. They also yield a full shape of the splenium for the 3D segmentation
Level-rank duality in Chern–Simons theory from a non-supersymmetric brane configuration

AbstractWe derive level-rank duality in pure Chern–Simons gauge theories from a non-supersymmetric Seiberg duality by using a non-supersymmetric brane configuration in type IIB string theory. The brane configuration consists of fivebranes, N D3 antibranes and an O3 plane. By swapping the fivebranes we derive a 3d non-supersymmetric Seiberg duality. After level shifts from loop effects, this identifies the IR of Sp(2N)2k−2N+2 and Sp(2k−2N+2)−2N pure Chern–Simons theories, which is a level-rank pair. We also derive level-rank duality in a Chern–Simons theory based on a unitary group
Quark–gluon antenna functions from neutralino decay

AbstractThe computation of exclusive QCD jet observables at higher orders requires a method for the subtraction of infrared singular configurations arising from multiple radiation of real partons. One commonly used method at next-to-leading order (NLO) is based on the antenna factorization of colour-ordered matrix elements, and uses antenna functions to subtract the real radiation singularities. Up to now, NLO antenna functions could be derived in a systematic manner only for hard quark–antiquark pairs, while the gluon–gluon and quark–gluon antenna functions were constructed from their limiting behaviour. In this Letter, we show that antenna functions for hard quark–gluon pairs can be systematically derived from an effective Lagrangian describing heavy neutralino decay. The infrared structure of the colour-ordered neutralino decay matrix elements at NLO and NNLO is shown to agree with the structure observed for parton radiation off a quark–gluon antenna
Single-valued Hamiltonian via Legendre–Fenchel transformation and time translation symmetry

AbstractUnder conventional Legendre transformation, systems with a non-convex Lagrangian will result in a multi-valued Hamiltonian as a function of conjugate momentum. This causes problems such as non-unitary time evolution of quantum state and non-determined motion of classical particles, and is physically unacceptable. In this work, we propose a new construction of single-valued Hamiltonian by applying Legendre–Fenchel transformation, which is a mathematically rigorous generalization of conventional Legendre transformation, valid for non-convex Lagrangian systems, but not yet widely known to the physics community. With the new single-valued Hamiltonian, we study spontaneous breaking of time translation symmetry and derive its vacuum state. Applications to theories of cosmology and gravitation are discussed
Potentials and limitations of SAR image simulators – A comparative study of three simulation approaches

AbstractVarious applications, like for instance algorithm design, mission planning, geo-referencing, change detection, Automatic Target Recognition (ATR) or SAR data analysis, rely on simulated synthetic aperture radar (SAR) images. However, there are different SAR simulation techniques with different advantages and disadvantages. Depending on the needs of a certain application, a suitable SAR simulation technique has to be used. This paper compares three SAR image simulation approaches, RaySAR, CohRaS®, and SARViz, showing their similarities and differences. RaySAR and CohRaS® are two ray tracing based SAR image simulators. RaySAR is based on the open-source software POV-Ray, while CohRaS® is developed as SAR simulator from scratch. The third simulator, SARViz, is a real-time SAR simulator based on the rasterization approach. The geometrical features of the three simulators are compared and the differences and different applications are analyzed
Heat of Absorption of CO2 in Aqueous Solutions of DEEA, MAPA and their Mixture

AbstractA reaction calorimeter was used to measure the differential heat of absorption of CO2 in phase change solvents as a function of temperature, CO2 loading and solvent composition. The measurements were taken for aqueous solutions of 2-(diethylamino)ethanol (DEEA), 3-(methylamino)propylamine (MAPA) and their mixture. The tested compositions were 5M DEEA, 2M MAPA and their mixture, 5M DEEA + 2M MAPA which gives two liquid phases on reacting with CO2. Experimental measurements were also carried out for 30% MEA used as a base case. The measurements were taken isothermally at three different temperatures 40, 80 and 120°C at a CO2 feed pressure of 600kPa. In single aqueous amine solutions, heat of absorption increases with increase in temperature and depends on thetype of amine used. DEEA, a tertiary amine, has lower heat of absorption compared to MAPA being a diamine with primary and secondary amine functional groups. For amine mixtures, heat of absorption is a function of CO2 loading and temperature. The heat of absorption against CO2 loading depends on the composition of the amines in the mixture. All the measured data in this work were compared with 30% MEA at absorption (40°C) and desorption (120°C) conditions
A short note on the cephalopods sampled in the Angola Basin during the DIVA-1 expedition

AbstractFive cephalopods, all belonging to different species, were identified from deep-sea trawl samples conducted during the DIVA 1-expedition of RV “Meteor” in the Angola Basin in July 2000. These were the teuthoid squids Bathyteuthis abyssicola, Brachioteuthis riisei, Mastigoteuthis atlantica, Galiteuthis armata, and the finned deep-sea octopus Grimpoteuthis wuelkeri. The present study contributes information on size, morphometry, biology and distribution of the species form this unique cephalopod collection
Sprint-based exercise and cognitive function in adolescents

AbstractModerate intensity exercise has been shown to enhance cognition in an adolescent population, yet the effect of high-intensity sprint-based exercise remains unknown and was therefore examined in the present study. Following ethical approval and familiarisation, 44 adolescents (12.6±0.6 y) completed an exercise (E) and resting (R) trial in a counter-balanced, randomised crossover design. The exercise trial comprised of 10×10s running sprints, interspersed by 50s active recovery (walking). A battery of cognitive function tests (Stroop, Digit Symbol Substitution (DSST) and Corsi blocks tests) were completed 30min pre-exercise, immediately post-exercise and 45min post-exercise. Data were analysed using mixed effect models with repeated measures. Response times on the simple level of the Stroop test were significantly quicker 45min following sprint-based exercise (R: 818±33ms, E: 772±26ms; p=0.027) and response times on the complex level of the Stroop test were quicker immediately following the sprint-based exercise (R: 1095±36ms, E: 1043±37ms; p=0.038), while accuracy was maintained. Sprint-based exercise had no immediate or delayed effects on the number of items recalled on the Corsi blocks test (p=0.289) or substitutions made during the DSST (p=0.689). The effect of high intensity sprint-based exercise on adolescents' cognitive function was dependant on the component of cognitive function examined. Executive function was enhanced following exercise, demonstrated by improved response times on the Stroop test, whilst visuo-spatial memory and general psycho-motor speed were unaffected. These data support the inclusion of high-intensity sprint-based exercise for adolescents during the school day to enhance cognition
Heritage, health and place: The legacies of local community-based heritage conservation on social wellbeing

AbstractGeographies of health challenge researchers to attend to the positive effects of occupying, creating and using all kinds of spaces, including ‘green space’ and more recently ‘blue space’. Attention to the spaces of community-based heritage conservation has largely gone unexplored within the health geography literature. This paper examines the personal motivations and impacts associated with people's growing interest in local heritage groups. It draws on questionnaires and interviews from a recent study with such groups and a conceptual mapping of their routes and flows. The findings reveal a rich array of positive benefits on the participants' social wellbeing with/in the community. These include personal enrichment, social learning, satisfaction from sharing the heritage products with others, and less anxiety about the present. These positive effects were tempered by needing to face and overcome challenging effects associated with running the projects thus opening up an extension to health-enabling spaces debates
BIM & the 5D Project Cost Manager

AbstractThis paper examines the global issues related to the role of project cost management professionals in the implementation and evolution of Building Information Modeling (BIM) in the construction industry. The paper is based on a review of current industry trends and issues with BIM implementation and detailed interviews with quantity surveying firms in Australia. BIM involves more than just 3D modelling and is also commonly defined in further dimensions such as 4D (time), 5D (cost) and even 6D (as-built operation). 4D links information and data in the 3D object model with project programming and scheduling data and facilitates the simulation analysis of construction activities. 5D integrates all of this information with cost data such as quantities, schedules and prices. 6D represents the as-built model that can then be used during the operational stages of the facility. This paper explores the importance for project cost management professionals to be integrally involved across all project phases and to embrace the 5th dimension to become key players in the BIM environment – the ‘5D Project Cost Manager’. The literature review and industry interviews will examine the issues associated with this and will identify leading edge best practices in the field by professional project cost management firms. The paper concludes with the findings that the greatest value with the modern day project cost manager lies in their ability to be 5D literate and to be able to utilise electronic models to provide detailed 5D estimates and living cost plans in real time
A Turnip yellow mosaic virus infection system in Arabidopsis suspension cell culture

AbstractTurnip yellow mosaic virus (TYMV) is a positive-strand RNA virus able to infect Arabidopsis thaliana. To establish a TYMV infection system in Arabidopsis cell culture, TYMV replicons with the capsid protein gene replaced by a reporter gene expressing the Sh ble protein conferring zeocin resistance were used to transfect Arabidopsis cells. Zeocin-resistant Arabidopsis calli were used to generate a suspension cell culture. Detection of viral proteins and RNAs after 18 months in culture demonstrated persistent replication of the replicon. The Arabidopsis cell culture yielded soluble, active replication complexes, providing a useful tool to study host factors involved in TYMV replication
Timelike and spacelike nucleon electromagnetic form factors beyond relativistic constituent quark models

AbstractFor the first time, a phenomenological analysis of the experimental electromagnetic form factors of the nucleon, both in the timelike and spacelike regions, is performed by taking into account the effects of nonvalence components in the nucleon state, within a light-front framework. Our model, based on suitable ansatzes for the nucleon Bethe–Salpeter amplitude and a microscopic version of the well-known Vector Meson Dominance model, has only four adjusted parameters (determined by the spacelike data with χ2/datum∼1.7), and yields a nice description of the experimental electromagnetic form factors in the physical region in the range −30(GeV/c)2<q2<20(GeV/c)2, except for the neutron one in the timelike region. Valuable information can be gained in the timelike region on possible missing Vector Mesons around q2∼4.5(GeV/c)2 and q2∼8.0(GeV/c)2
A refined Jensen’s inequality in Hilbert spaces and empirical approximations

AbstractLet f:X→R be a convex mapping and X a Hilbert space. In this paper we prove the following refinement of Jensen’s inequality: E(f|X∈A)≥E(f|X∈B) for every A,B such that E(X|X∈A)=E(X|X∈B) and B⊂A. Expectations of Hilbert-space-valued random elements are defined by means of the Pettis integrals. Our result generalizes a result of [S. Karlin, A. Novikoff, Generalized convex inequalities, Pacific J. Math. 13 (1963) 1251–1279], who derived it for X=R. The inverse implication is also true if P is an absolutely continuous probability measure. A convexity criterion based on the Jensen-type inequalities follows and we study its asymptotic accuracy when the empirical distribution function based on an n-dimensional sample approximates the unknown distribution function. Some statistical applications are addressed, such as nonparametric estimation and testing for convex regression functions or other functionals