pinecone/core-2020-05-10-deduplication huggingface dataset:
Effect of Quinapril, Quinapril-Hydrochlorothiazide, and Enalapril on the Bone Mass of Hypertensive Subjects: Relationship With Angiotensin Converting Enzyme Polymorphisms

Producción CientíficaBackground: Many alterations in extracellular metabolism
of calcium have been associated to hypertension, but
the number of studies relating this disease with osteoporosis
is extremely low. This study clarifies the therapeutic
effect of three treatments— quinapril, quinapril   hydrochlorothiazide
(HCTZ), enalapril—on bone remodeling
markers, bone mineral density (BMD) in hypertensive
patients, and relationship with angiotensin converting enzyme
(ACE) polymorphism.2015-09-0
At the Crossroads: The impact of new Irish science curricula on first year post-primary students

In Ireland, new science curricula were introduced at primary and early post- primary levels in 2003, in an effort to reverse declining interest and enrolment in science. This paper reports on a national study that explored first year post-primary students’ experiences of and attitudes towards school science under these new curricula. Data were gathered from 366 pupils using survey and case study approaches. Findings revealed broadly positive attitudes towards post-primary school science, especially the experimental work that is at the heart of the new curriculum. However, it would appear that students were not conducting open-ended investigations or using information and communications technology [ICT] to any great extent; moreover, there was some evidence of traditional teaching methods being utilised. Pupils were highly critical of previous primary school science experiences, reporting a lack of ‘hands-on’ activities, didactic methodologies and, for a significant minority, a paucity of any memorable primary science at all. Improvements in curricular implementation are proposed
Self-activated mesh device using shape memory alloy for periosteal expansion osteogenesis

The present study evaluated the use of this self-activated shape memory alloy (SMA) device, with a focus on its effects in the region under the periosteum. Twelve Japanese white rabbits were used in this study. The device was inserted under the periosteum at the forehead. In the experimental group, the device was pushed, bent, and attached to the bone surface and fixed with a titanium screw. In control group, the device was only inserted under the periosteum. After 14 days, the screw was removed and the mesh was activated in the experimental group. Rabbits were sacrificed 5 and 8 weeks after the operation and newly formed bone was histologically and radiographically evaluated. The quantitative data by the area and the occupation of newly formed bone indicated that the experimental group had a higher volume of new bone than the control group at each consolidation period. Histologically, some newly formed bone was observed and most of the subperiosteal space underneath the device was filled with fibrous tissue, and a thin layer of immature bone was observed in the control group. In the experimental group, multiple dome-shaped bones, outlined by thin and scattered trabeculae, were clearly observed under the SMA mesh device. The use of self-activated devices for the periosteal expansion technique may make it possible to avoid donor site morbidity, trans-skin activation rods, any bone-cutting procedure, and the following intermittent activation procedure
Extracting diagnostic knowledge from MedLine Plus: a comparison between MetaMap and cTAKES Approaches

The development of diagnostic decision support systems (DDSS) requires having a reliable and\ud
consistent knowledge base about diseases and their symptoms, signs and diagnostic tests. Physicians are\ud
typically the source of this knowledge, but it is not always possible to obtain all the desired information from\ud
them. Other valuable sources are medical books and articles describing the diagnosis of diseases, but again, extracting this\ud
information is a hard and time-consuming task. In this paper we present the results of our research, in which we have used\ud
Web scraping, natural language processing techniques, a variety of publicly available sources of diagnostic knowledge\ud
and two widely known medical concept identifiers, MetaMap and cTAKES, to extract diagnostic criteria for infectious\ud
diseases from MedLine Plus articles. A performance comparison of MetaMap and cTAKES is also presented
CHEMICALLY- BONDED BRICK PRODUCTION BASED ON BURNT CLAY BY MEANS OF SEMIDRY PRESSING

We presented a study on the possibility of using the burned rocks of the Krasnoyarsk Territory for production
chemically- bonded materials in the form of bricks, so widely used in multistory housing and private house building. The
radiographic analysis of the composition of burnt rock was conducted and a modifier to adjust the composition uniformity
was identified. The mixing moisture content was identified and optimal amount at 13-15% was determined. The method of
semidry pressing has been chosen. The process of obtaining moldings has been theoretically proved, the advantages of
chemically- bonded wall materials compared to ceramic brick were shown. The production of efficient artificial stone based
on material burnt rocks, which is comparable with conventionally effective ceramic materials or effective with cell tile was
proved, the density of the burnt clay - based cell tile makes up 1630-1785 kg \ m3, with compressive strength of 13,6-20,0
MPa depending on the compression ratio and cement consumption, frost resistance index is F50, and the thermal
conductivity in the masonry is λ = 0,459-0,546 W \ m * 0C. The clear geometric dimensions of pressed products allow the use of the chemically- bonded brick based on burnt clay as a facing brick
The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression

Abstract5-Hydroxymethylcytosine (5hmC) was recently described as a stable modification in mammalian DNA. 5hmC is formed by the enzymatic oxidation of 5-methylcytosine (5meC). Overwhelming evidence supports the notion that 5meC has a negative effect on transcription; however, only recently has the effect that 5hmC has on transcription begun to be studied. Using model substrates including the CMVIE promoter and a generic gene body we have directly assessed the effect that 5hmC, both at the promoter and in the gene body, has on in vitro gene transcription. We show that the presence of the 5hmC modifications strongly represses transcription. We also demonstrate that the inhibition of transcriptional activity is primarily due to the presence of 5hmC in the promoter and that 5hmC in the gene body has a minimal effect on transcription. Thus, we propose that the presence of 5hmC in promoter prevents the binding of essential transcription factors or recruits factors that repress transcription
Mutations in FBXL4, Encoding a Mitochondrial Protein, Cause Early-Onset Mitochondrial Encephalomyopathy

Whole-exome sequencing and autozygosity mapping studies, independently performed in subjects with defective combined mitochondrial OXPHOS-enzyme deficiencies, identified a total of nine disease-segregating FBXL4 mutations in seven unrelated mitochondrial disease families, composed of six singletons and three siblings. All subjects manifested early-onset lactic acidemia, hypotonia, and developmental delay caused by severe encephalomyopathy consistently associated with progressive cerebral atrophy and variable involvement of the white matter, deep gray nuclei, and brainstem structures. A wide range of other multisystem features were variably seen, including dysmorphism, skeletal abnormalities, poor growth, gastrointestinal dysmotility, renal tubular acidosis, seizures, and episodic metabolic failure. Mitochondrial respiratory chain deficiency was present in muscle or fibroblasts of all tested individuals, together with markedly reduced oxygen consumption rate and hyperfragmentation of the mitochondrial network in cultured cells. In muscle and fibroblasts from several subjects, substantially decreased mtDNA content was observed. FBXL4 is a member of the F-box family of proteins, some of which are involved in phosphorylation-dependent ubiquitination and/or G protein receptor coupling. We also demonstrate that FBXL4 is targeted to mitochondria and localizes in the intermembrane space, where it participates in an approximately 400 kDa protein complex. These data strongly support a role for FBXL4 in controlling bioenergetic homeostasis and mtDNA maintenance. FBXL4 mutations are a recurrent cause of mitochondrial encephalomyopathy onset in early infancy
Wnt5A Activates the Calpain-Mediated Cleavage of Filamin A

We have previously shown that Wnt5A and ROR2, an orphan tyrosine kinase receptor, interact to mediate melanoma cell motility. In other cell types, this can occur through the interaction of ROR2 with the cytoskeletal protein filamin A. Here, we found that filamin A protein levels correlated with Wnt5A levels in melanoma cells. Small interfering RNA (siRNA) knockdown of WNT5A decreased filamin A expression. Knockdown of filamin A also corresponded to a decrease in melanoma cell motility. In metastatic cells, filamin A expression was predominant in the cytoplasm, which western analysis indicated was due to the cleavage of filamin A in these cells. Treatment of nonmetastatic melanoma cells with recombinant Wnt5A increased filamin A cleavage, and this could be prevented by the knockdown of ROR2 expression. Further, BAPTA-AM chelation of intracellular calcium also inhibited filamin A cleavage, leading to the hypothesis that Wnt5A/ROR2 signaling could cleave filamin A through activation of calcium-activated proteases, such as calpains. Indeed, WNT5A knockdown decreased calpain 1 expression, and by inhibiting calpain 1 either pharmacologically or using siRNA, it decreased cell motility. Our results indicate that Wnt5A activates calpain-1, leading to the cleavage of filamin A, which results in a remodeling of the cytoskeleton and an increase in melanoma cell motility
Using game authoring platforms to develop screen-based simulated functional assessments in persons with executive dysfunction following traumatic brain injury

The assessment of functional status is a critical component of clinical neuropsychological
evaluations used for both diagnostic and therapeutic purposes in patients with cognitive brain
disorders. There are, however, no widely adopted neuropsychological tests that are both
ecologically valid and easily administered in daily clinical practice. This discrepancy is a
roadblock to the widespread adoption of functional assessments. In this paper, we propose a novel approach using a serious game authoring platform (eAdventure) for creating screenbased
simulated functional assessments. We created a naturalistic functional task that
consisted of preparing a cup of tea (SBS-COT) and applied the assessment in a convenience
sample of eight dyads of therapists/patients with mild executive dysfunction after traumatic
brain injury. We had three main aims. First, we performed a comprehensive review of
executive function assessment in activities of daily living. Second, we were interested in
measuring the feasibility of this technology with respect to staffing, economic and technical
requirements. Third, a serious game was administered to patients to study the feasibility of
this technology in the clinical context (pre-screening test). In addition, quantitative
(Technology Acceptance Model (TAM) questionnaires) and qualitative (semistructured
interviews) evaluations were applied to obtain user input. Our results suggest that the
staffing, economic and technical requirements of the SBS-COT are feasible. The outcomes of
the pre-screening test provide evidence that this technology is useful in the functional
assessment of patients with executive dysfunction. In relation to subjective data, the TAM
questionnaire showed good user acceptability from a professional perspective. Interview
analyses with professionals and patients showed positive experiences related to the use of the
SBS-COT. Our work indicates that the use of these types of authoring platforms could have
positive long-term implications for neuropsychological research, opening the door to more
reproducible, cooperative and efficient research by allowing the facilitated production, reuse
and sharing of neuropsychological assessment tools.This study is part of the RAGE project. The RAGE project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 644187.  This publication reflects only the author's view. The European Commission is not responsible for any use that may be made of the information it contains
Two-photon absorption photocurrent enhancement in bulk AlGaAs semiconductor microcavities

We report on two-photon absorption (TPA) photocurrent in semiconductor microcavities. We experimentally show a substantial increase in the TPA photocurrent generated, at resonance, in a GaAlAs/GaAs microcavity designed for TPA operation at ~890 nm. An enhancement factor of ~12 000 of the photocurrent is obtained via the microcavity effect, which could have an important impact on the use of TPA devices for high speed switching and sampling applications. Our results also show the implications of the cavity photon lifetime on autocorrelation traces measured using TPA in semiconductor microcavities
4p-inner-shell and double-excitation spectrum of Sr II

We report photoabsorption measurements from the 4p inner shell of singly ionized strontium in the spectral region between 26.0 and 37.4  eV. More than 60 levels of Sr  II are reported which are interpreted as singly excited inner-shell transitions 4p65s 2S1∕2→4p45s(1P,3P)ns, md and doubly excited transitions 4p65s 2S1∕2→4p54d(1P,3P,3D)nl. Multiconfiguration Hartree-Fock calculations are performed in jj coupling and the levels are arranged into Rydberg series converging on seven limits, allowing the identification of two levels in Sr  III
Laminar gas jets in high-temperature atmospheres

Numerical and asymptotic methods are used to describe the structure of low-temperature laminar gas jets discharging into a hot atmosphere of the same gas in the limit of small jet-to-ambient temperature ratios " = Tj/To 1. In the limit " ! 0, heat conduction cannot modify significantly the temperature in the cold gas, leading to a two-region flow structure consisting of a neatly defined unperturbed cold jet for r < rf (x), where T = T0/To = " and u = U0/Uj = 1, surrounded by a hot gas. These two region are separated by a transition layer where T − " " and 1 − u 1. In planar jets the front thickens with distance achieving thickness of order unity at axial distances x "−(1+)Rea forcing the near-axis fluid to change slowly its velocity and temperature, being necessary distances x "−2Rea to reach values of T and 1−u of order unity. In round jets the front remains at r = a up to distances x "−(1−)(log "−1)2 where the front is forced to move radially towards the axis of the jet, reaching r = 0 at x "−1 log "−1Rea. The arrival of the front forces the change of the velocity and temperature in the near-axis region, reaching values of order unity in a far field region of characteristic length x "−1 log "−1Rea, distance comparable to that needed by the front to achieve the axis. In both geometries, the distance necessary for the fully development of the cold jet is considerably longer than that required by the isothermal jet x Rea
MIRACLE Progress in Monolingual Information Retrieval at Ad-Hoc CLEF 2007

This paper presents the 2007 MIRACLE’s team approach to the Ad-Hoc Information Retrieval track. The main work carried out for this campaign has been around monolingual experiments, in the standard and in the robust tracks. The most important contributions have been the general introduction of automatic named-entities extraction and the use of Wikipedia resources. For the2007 campaign, runs were submitted for the following languages and tracks: a) Monolingual: Bulgarian, Hungarian, and Czech. b) Robust monolingual: French, English and Portuguese
Wobbling of a liquid column between unequal discs

One of the most puzzling results of an experiment on the stability of long liquid columns under microgravity, performed aboard Spacelab-D2 in 1993 and named STACO, aiming at the analysis of deformations of nearly cylindrical liquid columns under several mechanical disturbances, is revisited here. It corresponds to the unexplained breakage of an 85 mm long liquid bridge of low viscosity silicone oil, established between unequal discs of 30 and 28 mm, intended to counterbalance the expected deformation by residual acceleration found in previous flights, and left idle because the vibrations and oscillations to be applied afterwards were not started, for fear of premature breakage. A detailed image analysis is performed to extract the maximum amount of data, to be able to check against available theories for axisymmetric and non-axisymmetric deformations of a liquid column
Lipid binding proteins from the endosperms of wheat and Oats

A protein, designated lipid binding protein (LBP), has been purified from the petrol extracts of wheat and oat endosperms by hydrochloric acid precipitation in a non-polar medium and preparative electrophoresis. The purified LBP appeared to be homogeneous both by electrophoresis in sodium dodecyl sulphate-polyacrylamide (SDS-PAGE) gels (MW ca 14 500) and by electrophoresis (PAGE) at pH 3.2. The amino acid composition indicates a high degree of homology between the LBPs from the two sources, as judged by the indexes of Cornish-Bowden and of Harris and Teller. As in the case of thionin, a previously characterized polypeptide from the ether extract, LBP becomes ether-insoluble, chloroform-soluble by precipitation with acetone, and solubility in ether is restored by binding of digalactosyl diglyceride to the chloroform-soluble form
Detection of seeds in citrus using MRI under motion conditions and improvement with motion correction

Magnetic resonance imaging (MRI) is studied under an online strategy. Axial FLASH images (780 ms acquisition time) have been analyzed to identify seed-containing oranges conveyed at 50 and 100 mm/s through a 4.7 Tesla spectrometer. Developed algorithms enable an automated identification of oranges with more than one seed, though axial images under motion conditions suffer from significant blurring artifacts. To overcome this hindrance, coronal FLASH images have been acquired (279 ms acquisition time), developing devoted algorithms for motion correction with encouraging results for quality improvement of dynamic image
Explicit processing of verbal and spatial features during letter-location binding modulates oscillatory activity of a fronto-parietal network.

The present study investigated the binding of verbal and spatial features in immediate memory. In a recent study, we demonstrated incidental and asymmetrical letter-location binding effects when participants attended to letter features (but not when they attended to location features) that were associated with greater oscillatory activity over prefrontal and posterior regions during the retention period. We were interested to investigate whether the patterns of brain activity associated with the incidental binding of letters and locations observed when only the verbal feature is attended differ from those reflecting the binding resulting from the controlled/explicit processing of both verbal and spatial features. To achieve this, neural activity was recorded using magnetoencephalography (MEG) while participants performed two working memory tasks. Both tasks were identical in terms of their perceptual characteristics and only differed with respect to the task instructions. One of the tasks required participants to process both letters and locations. In the other, participants were instructed to memorize only the letters, regardless of their location. Time–frequency representation of MEG data based on the wavelet transform of the signals was calculated on a single trial basis during the maintenance period of both tasks. Critically, despite equivalent behavioural binding effects in both tasks, single and dual feature encoding relied on different neuroanatomical and neural oscillatory correlates. We propose that enhanced activation of an anterior–posterior dorsal network observed in the task requiring the processing of both features reflects the necessity for allocating greater resources to intentionally process verbal and spatial features in this task
Tools for Search Tree Visualization: The APT Tool

The control part of the execution of a constraint logic program can be conceptually shown as a search-tree, where nodes correspond to calis, and whose branches represent conjunctions and disjunctions. This tree represents the search space traversed by the program, and has also a direct\ud
relationship with the amount of work performed by the program. The nodes of the tree can be used to display information regarding the state and origin of instantiation of the variables involved in each cali. This depiction can also be used for the enumeration process. These are the features implemented in APT, a tool which runs constraint logic programs while depicting a (modified) search-tree, keeping at the same time information about the state of the variables at every moment in the execution. This information can be used to replay the execution at will, both forwards and backwards in time. These views can be abstracted when the size of the execution requires it. The search-tree view is used as a framework onto which constraint-level visualizations (such as those presented in the following chapter) can be attached
Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches

We performed global RNA transcript analysis and comprehensive gene group analysis of peripheral blood leukocyte (PBL) RNA from two groups of matched sib-pairs that were discordant for either schizophrenia (n = 33 sib-pairs) or bipolar disorder (n = 5 sib-pairs). The pairs chosen for these analyses were selected from families with known patterns of genetic linkage (5q for schizophrenia and 6q for bipolar disorder). At the single gene level, we obtained lists of the transcripts with the most significant changes in expression and from these lists determined those with the highest degree of predictive power for classifying subjects according to diagnosis in these samples. At the gene group level, we comprehensively analyzed pairwise expression changes of more than 4,000 functional groups and cytogenetic locations, and present a novel method of displaying these data that we term ldquocytogenomicrdquo mapping. Verification of selected changes in expression was performed using quantitative real-time RT-PCR. Our results provide compelling evidence for the utility of analyzing PBL RNA for changes in expression in neuropsychiatric disorders. © 2005 Wiley-Liss, Inc.http://dx.doi.org/10.1002/ajmg.b.3017