pinecone/core-2020-05-10-deduplication huggingface dataset:
UVB-Induced Skin Inflammation and Cutaneous Tissue Injury Is Dependent on the MHC Class I–Like Protein, CD1d

CD1d is a major histocompatibility complex class 1–like molecule that regulates the function and development of natural killer T (NKT) cells. Previously, we identified a critical role for the CD1d-NKT cell arm of innate immunity in promoting the development of UVB-induced p53 mutations, immune suppression, and skin tumors. Sunburn, an acute inflammatory response to UVB-induced cutaneous tissue injury, represents a clinical marker for non-melanoma skin cancer (NMSC) risk. However, the innate immune mechanisms controlling sunburn development are not considered relevant in NMSC etiology, and remain poorly investigated. Here we found that CD1d knockout (CD1d−/−) mice resist UVB-induced cutaneous tissue injury and inflammation compared with wild-type (WT) mice. This resistance was coupled with a faster epithelial tissue healing response. In contrast, the skins of UVB-irradiated invariant NKT cell-knockout (Jα18−/−) and NKT cell–deficient (TCRα−/−) mice, which express CD1d but are deficient in CD1d-dependent NKT cells, exhibited as much cutaneous tissue injury and inflammation as WT mice. In the absence of NKT cells, CD1d-deficient keratinocytes, dendritic cells, and macrophages exhibited diminished basal and stress-induced levels of pro-inflammatory mediators. Thus, our findings identify an essential role for CD1d in promoting UVB-induced cutaneous tissue injury and inflammation. They also suggest sunburn and NMSC etiologies are immunologically linked
AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

SummaryMacrophages control the resolution of inflammation through the transition from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present evidence for a role of AMPKα1, a master regulator of energy homeostasis, in macrophage skewing that occurs during skeletal muscle regeneration. Muscle regeneration was impaired in AMPKα1−/− mice. In vivo loss-of-function (LysM-Cre;AMPKα1fl/fl mouse) and rescue (bone marrow transplantation) experiments showed that macrophagic AMPKα1 was required for muscle regeneration. Cell-based experiments revealed that AMPKα1−/− macrophages did not fully acquire the phenotype or the functions of M2 cells. In vivo, AMPKα1−/− leukocytes did not acquire the expression of M2 markers during muscle regeneration. Skewing from M1 toward M2 phenotype upon phagocytosis of necrotic and apoptotic cells was impaired in AMPKα1−/− macrophages and when AMPK activation was prevented by the inhibition of its upstream activator, CaMKKβ. In conclusion, AMPKα1 is crucial for phagocytosis-induced macrophage skewing from a pro- to anti-inflammatory phenotype at the time of resolution of inflammation
Disassembly of a Medial Transenvelope Structure by Antibiotics during Intracellular Division

SummaryChlamydiales possess a minimal but functional peptidoglycan precursor biosynthetic and remodeling pathway involved in the assembly of the division septum by an atypical cytokinetic machine and cryptic or modified peptidoglycan-like structure (PGLS). How this reduced cytokinetic machine collectively coordinates the invagination of the envelope has not yet been explored in Chlamydiales. In other Gram-negative bacteria, peptidoglycan provides anchor points that connect the outer membrane to the peptidoglycan during constriction using the Pal-Tol complex. Purifying PGLS and associated proteins from the chlamydial pathogen Waddlia chondrophila, we unearthed the Pal protein as a peptidoglycan-binding protein that localizes to the chlamydial division septum along with other components of the Pal-Tol complex. Together, our PGLS characterization and peptidoglycan-binding assays support the notion that diaminopimelic acid is an important determinant recruiting Pal to the division plane to coordinate the invagination of all envelope layers with the conserved Pal-Tol complex, even during osmotically protected intracellular growth
Stellar kinematics across the Hubble sequence in the CALIFA survey: general properties and aperture corrections

We present the stellar kinematic maps of a large sample of galaxies from the integral-field spectroscopic survey CALIFA. The sample comprises 300 galaxies displaying a wide range of morphologies across the Hubble sequence, from ellipticals to late-type spirals. This dataset allows us to homogeneously extract stellar kinematics up to several effective radii. In this paper, we describe the level of completeness of this subset of galaxies with respect to the full CALIFA sample, as well as the virtues and limitations of the kinematic extraction compared to other well-known integral-field surveys. In addition, we provide averaged integrated velocity dispersion radial profiles for different galaxy types, which are particularly useful to apply aperture corrections for single aperture measurements or poorly resolved stellar kinematics of high-redshift sources. The work presented in this paper sets the basis for the study of more general properties of galaxies that will be explored in subsequent papers of the survey
ARC : an open-source library for calculating properties of alkali Rydberg atoms.

We present an object-oriented Python library for computation of properties of highly-excited Rydberg states of alkali atoms. These include single-body effects such as dipole matrix elements, excited-state lifetimes (radiative and black-body limited) and Stark maps of atoms in external electric fields, as well as two-atom interaction potentials accounting for dipole and quadrupole coupling effects valid at both long and short range for arbitrary placement of the atomic dipoles. The package is cross-referenced to precise measurements of atomic energy levels and features extensive documentation to facilitate rapid upgrade or expansion by users. This library has direct application in the field of quantum information and quantum optics which exploit the strong Rydberg dipolar interactions for two-qubit gates, robust atom-light interfaces and simulating quantum many-body physics, as well as the field of metrology using Rydberg atoms as precise microwave electrometers
Search for supersymmetry in events with at least one photon, missing
  transverse momentum, and large transverse event activity in proton-proton
  collisions at sqrt(s) = 13 TeV

A search for physics beyond the standard model in final states with at least
one photon, large transverse momentum imbalance, and large total transverse
event activity is presented. Such topologies can be produced in gauge-mediated
supersymmetry models in which pair-produced gluinos or squarks decay to photons
and gravitinos via short-lived neutralinos. The data sample corresponds to an
integrated luminosity of 35.9 inverse femtobarns of proton-proton collisions at
sqrt(s) = 13 TeV recorded by the CMS experiment at the LHC in 2016. No
significant excess of events above the expected standard model background is
observed. The data are interpreted in simplified models of gluino and squark
pair production, in which gluinos or squarks decay via neutralinos to photons.
Gluino masses of up to 1.50-2.00 TeV and squark masses up to 1.30-1.65 TeV are
excluded at 95% confidence level, depending on the neutralino mass and
branching fraction.Comment: Replaced with the published version. Added the journal reference and
  DOI. All the figures and tables, including additional supplemental figures,
  can be found at
  http://cms-results.web.cern.ch/cms-results/public-results/publications/CMS-SUS=16-047
  (CMS Public Pages
Study of the underlying event at forward rapidity in pp collisions at √s = 0.9, 2.76, and 7 TeV

The underlying event activity in proton-proton collisions at forward pseudo-rapidity (—6.6 < η < —5.2) is studied with the CMS detector at the LHC, using a novel observable: the ratio of the forward energy density, dE/dη, for events with a charged-particle jet produced at central pseudorapidity (|ηjet| < 2) to the forward energy density for inclusive events. This forward energy density ratio is measured as a function of the central jet transverse momentum, pT, at three different pp centre-of-mass energies (√s = 0.9, 2.76, and 7TeV). In addition, the √s evolution of the forward energy density is studied in inclusive events and in events with a central jet. The results are compared to those of Monte Carlo event generators for pp collisions and are discussed in terms of the underlying event. Whereas the dependence of the forward energy density ratio on jet pT at each ^fs separately can be well reproduced by some models, all models fail to simultaneously describe the increase of the forward energy density with √s in both inclusive events and in events with a central jet. © 2013, CERN.The Scientific and Technical Research Council of Turkey, and Turkish Atomic Energy Authorit
XMM-Newton and INTEGRAL view of the hard state of EXO 1745-248 during its 2015 outburst

Context. Transient low-mass X-ray binaries (LMXBs) often show outbursts that typically last a few weeks and are characterized by a high X-ray luminosity (Lx â\u89\u88 1036-1038 erg s-1), while most of the time they are found in X-ray quiescence (LX â\u89\u88 1031-1033 erg s-1). The source EXO 1745-248 is one of them. Aims. The broad-band coverage and sensitivity of the instrument on board XMM-Newton and INTEGRAL offers the opportunity of characterizing the hard X-ray spectrum during the outburst of EXO 1745-248. Methods. We report on quasi-simultaneous XMM-Newton and INTEGRAL observations of the X-ray transient EXO 1745-248 located in the globular cluster Terzan 5, performed ten days after the beginning of the outburst (on 2015 March 16) of the source between March and June 2015. The source was caught in a hard state, emitting a 0.8-100 keV luminosity of â\u89\u83 1037 erg s-1. Results. The spectral continuum was dominated by thermal Comptonization of seed photons with temperature kTin â\u89\u83 1.3 keV, by a cloud with a moderate optical depth Ï\u84 â\u89\u83 2, and with an electron temperature of kTe â\u89\u83 40 keV. A weaker soft thermal component at temperature kTth â\u89\u83 0.6-0.7 keV and compatible with a fraction of the neutron star radius was also detected. A rich emission line spectrum was observed by the EPIC-pn on board XMM-Newton; features at energies compatible with K-Î± transitions of ionized sulfur, argon, calcium, and iron were detected, with a broadness compatible with either thermal Compton broadening or Doppler broadening in the inner parts of an accretion disk truncated at 20 Â± 6 gravitational radii from the neutron star. Strikingly, at least one narrow emission line ascribed to neutral or mildly ionized iron is needed to model the prominent emission complex detected between 5.5 and 7.5 keV. The different ionization state and broadness suggest an origin in a region located farther from the neutron star than where the other emission lines are produced. Seven consecutive type I bursts were detected during the XMM-Newton observation, none of which showed hints of photospheric radius expansion. A thorough search for coherent pulsations from the EPIC-pn light curve did not result in any significant detection. Upper limits ranging from a few to 15% on the signal amplitude were set, depending on the unknown spin and orbital parameters of the system
Developmental and sex differences in responses to novel objects : an exploration of animal models of sensation seeking behaviour

Electronic version excludes material for which permission has not been granted by the rights holderHuman adolescents exhibit higher levels of sensation seeking behaviour than younger or older individuals, and sensation seeking is higher in males than females from adolescence onwards.  Data suggest that changes in gonadal hormone levels during adolescence and differences in the dopamine neurotransmitter system are the bases for why some people exhibit sensation seeking behaviour while others do not. However, causal relationships between physiology and behaviour have been difficult to establish in humans. In order to explore the physiological influences on novelty-seeking behaviour, we looked at response to novelty in a laboratory rodent. This research examined responses to novelty in the conditioned place preference (CPP) task and the novel object recognition (NOR) task  in Lister-hooded rats, and assessed the benefits and limitations of each methodology. While the CPP task was not found to provide a reliable measure of response to novelty, the NOR task was more successful. In order to understand the ontogeny of sex differences in novelty responses, both males and females were tested from adolescence through to adulthood.  While no sex difference was found in adults in the NOR test, mid-adolescent males exhibited higher novelty preference behaviour than either younger or older males, or females at each stage of development. Since gonadal hormones levels rise during adolescence, a pharmacological agent (a gonadotrophin-releasing hormone antagonist) was used to suppress gonadal hormone levels from early adolescence before again examining responses on the NOR test at mid-adolescence.  Gonadal hormone suppression from early adolescence onwards eliminated the sex difference in the NOR test at mid-adolescence by reducing the male response to novelty, while no difference was measured in the female animals.  These findings suggest that gonadal hormones play a significant role in the development of response to novelty, especially in males, and the implications for our understanding of human sensation-seeking behaviour are discussed
The role of human resource practices in developing knowledge and learning capabilities for innovation: A study of IT service providers in India

This paper examines the role of human resource practices in the development of knowledge and learning capabilities for innovation for information technology service providers (ITSP) in India. Developing knowledge and learning capabilities for innovation has been the subject of much attention from industry, governments and researchers. However, the questions surrounding how human resource practices influence the development of knowledge and learning capabilities that lead to organizational innovation remains unclear; particularly for knowledge intensive firms in developing countries. The study draws from the experience of 11 of the largest ITSPs in India and based on in-depth interviews. The findings suggest that while traditional human resource practices are important, senior executives should take a strategic approach in developing human resource practices with knowledge and learning capabilities as central piece for organizational innovation
Energy market reforms in Turkey: An economic analysis

In the early 2000s, the Republic of Turkey has initiated an ambitious reform program in the most important segments of her energy market; namely, electricity, natural gas, petroleum and liquefied petroleum gas industries, which requires privatization, liberalization as well as a radical restructuring of these industries. However, there is no consensus that the measures introduced are optimal. The present dissertation attempts to answer, first, whether or not recently introduced energy market reforms in Turkey are optimal from an economic perspective to ensure a fully functioning energy market; and second, what still needs to be done to improve them. The dissertation not only provides an economic analysis of these reforms but also lists some policy suggestions with crucial importance. Since the rapid electricity demand growth is the most contentious reason behind the recent reforms; the dissertation specifically focuses on the issue by both providing an electricity demand estimation and forecast, and comparing the results with official projections. The study concludes that despite relatively good legislative framework, in practice, the reforms in Turkey are far from ideal as they are mainly in the form of "textbook reforms"; and therefore a significant amount of work still lies ahead of Turkey to set up a fully-fledged energy market.
A conditional full frontier modelling for analyzing environmental efficiency and economic growth

By applying conditional and unconditional data envelopment analysis (DEA) models along side with statistical inference using bootstrap techniques; this paper investigates the link between China’s carbon dioxide emissions (CO2) environmental efficiency and its economic growth (measured in GNI per capita) for the time period of 1965 to 2009. The results reveal that China’s changing consumption patterns has caused emissions levels to increase dramatically the last two decades providing clear evidence of a negative effect of China’s GNI per capita increase on its environmental efficiency.
Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans.

<span class="Apple-style-span" style="font-family: arial; line-height: 18px;">The ferrous iron and 2-oxoglutarate (2OG) dependent oxygenases catalyse two electron oxidation reactions by coupling the oxidation of substrate to the oxidative decarboxylation of 2OG, giving succinate and carbon dioxide coproducts. The evidence available on the level of incorporation of one atom from dioxygen into succinate is inconclusive. Here, we demonstrate that five members of the 2OG oxygenase family, AlkB from&nbsp;<i>Escherichia coli</i>, anthocyanidin synthase and flavonol synthase from&nbsp;<i>Arabidopsis thaliana</i>, and prolyl hydroxylase domain enzyme 2 and factor inhibiting hypoxia-inducible factor-1 from&nbsp;<i>Homo sapiens</i>&nbsp;all incorporate a single oxygen atom, almost exclusively derived from dioxygen, into the succinate co-product.</span><br /
Bio-Inspired Local Information-Based Control for Probabilistic Swarm
  Distribution Guidance

This paper addresses a task allocation problem for a large-scale robotic
swarm, namely swarm distribution guidance problem. Unlike most of the existing
frameworks handling this problem, the proposed framework suggests utilising
local information available to generate its time-varying stochastic policies.
As each agent requires only local consistency on information with neighbouring
agents, rather than the global consistency, the proposed framework offers
various advantages, e.g., a shorter timescale for using new information and
potential to incorporate an asynchronous decision-making process. We perform
theoretical analysis on the properties of the proposed framework. From the
analysis, it is proved that the framework can guarantee the convergence to the
desired density distribution even using local information while maintaining
advantages of global-information-based approaches. The design requirements for
these advantages are explicitly listed in this paper. This paper also provides
specific examples of how to implement the framework developed. The results of
numerical experiments confirm the effectiveness and comparability of the
proposed framework, compared with the global-information-based framework.Comment: Submitted to IEEE Transactions on Robotic
Measurement of W boson angular distributions in events with high transverse momentum jets at s=8 TeV using the ATLAS detector

The W   boson angular distribution in events with high transverse momentum jets is measured using data collected by the ATLAS experiment from proton–proton collisions at a centre-of-mass energy View the MathML sources=8 TeV at the Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb−120.3 fb−1. The focus is on the contributions to W+jetsW+jets processes from real W emission, which is achieved by studying events where a muon is observed close to a high transverse momentum jet. At small angular separations, these contributions are expected to be large. Various theoretical models of this process are compared to the data in terms of the absolute cross-section and the angular distributions of the muon from the leptonic W decay.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, UGC, Hong Kong SAR, China; ISF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC ICI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Knut and Alice Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States. In addition, individual groups and members have received support from BCKDF, the Canada Council, CANARIE, CRC, Compute Canada, FQRNT, and the Ontario Innovation Trust, Canada; EPLANET, ERC, FP7, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex and Idex, ANR, Region Auvergne and Fondation Partager le Savoir, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF; BSF, GIF and Minerva, Israel; BRF, Norway; Generalitat de Catalunya, Generalitat Valenciana, Spain; the Royal Society and Leverhulme Trust, United Kingdom.info:eu-repo/semantics/publishedVersio
Equivalent Young’s Modulus of the Spiral Accumulating Motor Core Including Many Slits and Embossing Interlockings

The motor core is usually manufactured from magnetic steel sheet with press machine. However, usually most parts of the plate are scalped, and only small percent of the sheet is used for the core. The spiral accumulating core system is suitable for manufacturing the core more ecologically because in this system more than 50% of the magnetic steel sheet can be used. However, since the spiral accumulating core has many slits and embossing interlockings, the equivalent Young\u27s modulus is not known. In this study, therefore, the equivalent Young\u27s modulus of the spiral accumulating core is considered in order to find out a good method to fix the core. Here, the finite element method is applied to analyze the permanent magnet motor core, whose layers and slits are periodically arranged. Then, the effects of slits, layers and embossing interlockings on equivalent Young\u27s modulus are discussed. It is found that around the slits the core layer should be considered to have zero elastic modulus because no tangential stress exists. Finally, a convenient method of calculation based on rule of mixture is newly proposed to estimate the equivalent Young\u27s modulus efficiently.11th International Conference on the mechanical behavior of Materials (ICM11), 5-9 June 2011, Como, Ital