pinecone/core-2020-05-10-deduplication huggingface dataset:
Current practices in long-term video-EEG monitoring services: A survey among partners of the E-PILEPSY pilot network of reference for refractory epilepsy and epilepsy surgery

AbstractPurposeThe European Union-funded E-PILEPSY network aims to improve awareness of, and accessibility to, epilepsy surgery across Europe. In this study we assessed current clinical practices in epilepsy monitoring units (EMUs) in the participating centers.MethodA 60-item web-based survey was distributed to 25 centers (27 EMUs) of the E-PILEPSY network across 22 European countries. The questionnaire was designed to evaluate the characteristics of EMUs, including organizational aspects, admission, and observation of patients, procedures performed, safety issues, cost, and reimbursement.ResultsComplete responses were received from all (100%) EMUs surveyed. Continuous observation of patients was performed in 22 (81%) EMUs during regular working hours, and in 17 EMUs (63%) outside of regular working hours. Fifteen (56%) EMUs requested a signed informed consent before admission. All EMUs performed tapering/withdrawal of antiepileptic drugs, 14 (52%) prior to admission to an EMU. Specific protocols on antiepileptic drugs (AED) tapering were available in four (15%) EMUs. Standardized Operating Procedures (SOP) for the treatment of seizure clusters and status epilepticus were available in 16 (59%). Safety measures implemented by EMUs were: alarm seizure buttons in 21 (78%), restricted patient's ambulation in 19 (70%), guard rails in 16 (59%), and specially designated bathrooms in 7 (26%). Average costs for one inpatient day in EMU ranged between 100 and 2200 Euros.ConclusionThis study shows a considerable diversity in the organization and practice patterns across European epilepsy monitoring units. The collected data may contribute to the development and implementation of evidence-based recommended practices in LTM services across Europe
Effects of ursolic acid on the structural and morphological behaviours of dipalmitoyl lecithin vesicles

AbstractEffects of ursolic acid on the structural and morphological characteristics of dipalmitoyl lecithin(DPPC)-water system was studied by using differential scanning calorimetry (DSC), small- and wide-angle X-ray scattering (SWAXS), freeze-fracture method combined with transmission electron-microscopy (FF-TEM) and infrared spectroscopy (FT-IR). The surface of the uncorrelated lipid system is rippled or grained and a huge number of small, presumably unilamellar vesicles are present if the UA/DPPC molar ratio is 0.1mol/mol or higher. Besides the destroyed layer packing of regular multilamellar vesicles, non-bilayer (e.g. cubic or hexagonal) local structures are evidenced by SAXS and FF-TEM methods. The ability of UA to induce non-bilayer structures in hydrated DPPC system originates from the actual geometry form of associated lipid and UA molecules as concluded from the FT-IR measurements and theoretical calculations. Beside numerous beneficial e.g. chemopreventive and chemotherapeutic effect of ursolic acid against cancer, their impact to modify the lipid bilayers can be utilized in liposomal formulations
Dispersion relations and soft pion theorems for K→ππ

AbstractWe propose a new method to obtain the K→ππ amplitude from K→π which allows one to fully account for the effects of final state interactions. The method is based on a set of dispersion relations for the K→ππ amplitude in which the weak Hamiltonian carries momentum. The soft pion theorem, which relates this amplitude to the K→π amplitude, can be used to determine one of the two subtraction constants—the second constant is at present known only to leading order in chiral perturbation theory. We solve the dispersion relations numerically and express the result in terms of the unknown higher order corrections to this subtraction constant
Low adherence of Swiss children to national dietary guidelines

AbstractIntroductionDietary guidelines aim to inform people of the types of foods and quantities they should consume each day or week to promote and maintain health. The aim of this study was to describe children's dietary behaviors in terms of adherence to the Swiss Society for Nutrition (SSN) dietary guidelines and possible determinants.MethodsA cross-sectional study was conducted in September 2010 with 568 children aged 6–12years old living in Ticino Switzerland. Food intake was collected using 7-day food logs. Adherence with the dietary guidelines from the SSN was assessed according to age group.ResultsWith the exception of fish and cereal/potato intake (adherence rates of 68.5% and 47.9%, respectively), adherence to SSN guidelines was low: 26.9% for meat; 22.7% for eggs; 10.4% for fruit; 9.5% for sweets, snacks & soft drinks; 3.5% for milk & dairy, and 0% for vegetables. Multivariate analysis showed no consistent association between the child or their parent's socio-demographic characteristics and adherence to SSN guidelines. Girls had a higher likelihood of adhering with fruit and meat guidelines: multivariate adjusted odds ratio (95% confidence interval) 1.98 (1.10–3.56) and 1.80 (1.08–2.99), respectively. Children aged 10 to 12 had a lower likelihood of adhering with cereals and potatoes 0.48 (0.29–0.78), and a higher likelihood of adhering with the guideline for eggs 1.78 (1.00–3.15).ConclusionDietary intake of Ticinese children shows poor adherence with SSN guidelines. Given the lack of specific socio-demographic factors associated with adherence, population-wide interventions to improve dietary intake are necessary
Supersymmetric grand unification model with the orbifold symmetry breaking in the six-dimensional supergravity

AbstractWe construct supersymmetric (SUSY) grand unification (GUT) models in the six-dimensional space–time where the GUT symmetry is broken down to the standard-model gauge group by a simple orbifolding T2/Z4 or T2/Z6 and a pair of massless Higgs doublets in the SUSY standard model are naturally obtained. Since the background geometry here is simple compared with models using the Scherk–Schwarz mechanism, one might hope for an approximate gauge coupling unification in the present models. Here, the presence of the massless Higgs multiplets in the bulk is quite natural, since the anomaly cancellation in the six-dimensional space–time requires N=2 hyper multiplets in the bulk, some of which are origins of the Higgs doublets. However, the origin of the quarks and leptons is still not clear at all
Beurling–Landau densities of weighted Fekete sets and correlation kernel estimates

AbstractLet Q be a suitable real function on C. An n-Fekete set corresponding to Q is a subset {zn1,…,znn} of C which maximizes the expression ∏i<jn|zni−znj|2e−n(Q(zn1)+⋯+Q(znn)). It is well known that, under reasonable conditions on Q, there is a compact set S known as the “droplet” such that the measures μn=n−1(δzn1+⋯+δznn) converges to the equilibrium measure ΔQ⋅1SdA as n→∞. In this note we prove that Fekete sets are, in a sense, maximally spread out with respect to the equilibrium measure. In general, our results apply only to a part of the Fekete set, which is at a certain distance away from the boundary of the droplet. However, for the potential Q=|z|2 we obtain results which hold globally, and we conjecture that such global results are true for a wide range of potentials
Effective theories and measurements at colliders

AbstractIf the LHC run 2 will not provide conclusive hints for new resonant Physics beyond the Standard Model, dedicated and consistent search strategies at high momentum transfers will become the focus of searches for anticipated deviations from the Standard Model expectation. We discuss the phenomenological importance of QCD and electroweak corrections in bounding higher dimensional operators when analysing energy-dependent differential distributions. In particular, we study the impact of RGE-induced operator running and mixing effects on measurements performed in the context of an Effective Field Theory extension of the SM. Furthermore, we outline a general analysis strategy which allows a RGE-improved formulation of constraints free of theoretical shortcomings that can arise when differential distributions start to probe the new interaction scale. We compare the numerical importance of such a programme against the standard analysis approach which is widely pursued at present
Measurement of W+W− production in association with one jet in proton–proton collisions at s=8TeV with the ATLAS detector

AbstractThe production of W boson pairs in association with one jet in pp collisions at s=8 TeV is studied using data corresponding to an integrated luminosity of 20.3 fb−1 collected by the ATLAS detector during 2012 at the CERN Large Hadron Collider. The cross section is measured in a fiducial phase-space region defined by the presence of exactly one electron and one muon, missing transverse momentum and exactly one jet with a transverse momentum above 25 GeV and a pseudorapidity of |η|<4.5. The leptons are required to have opposite electric charge and to pass transverse momentum and pseudorapidity requirements. The fiducial cross section is found to be σWWfid,1-jet=136±6(stat)±14(syst)±3(lumi) fb. In combination with a previous measurement restricted to leptonic final states with no associated jets, the fiducial cross section of WW production with zero or one jet is measured to be σWWfid,≤1-jet=511±9(stat)±26(syst)±10(lumi) fb. The ratio of fiducial cross sections in final states with one and zero jets is determined to be 0.36±0.05. Finally, a total cross section extrapolated from the fiducial measurement of WW production with zero or one associated jet is reported. The measurements are compared to theoretical predictions and found in good agreement
On matrix-model approach to simplified Khovanov–Rozansky calculus

AbstractWilson-loop averages in Chern–Simons theory (HOMFLY polynomials) can be evaluated in different ways – the most difficult, but most interesting of them is the hypercube calculus, the only one applicable to virtual knots and used also for categorification (higher-dimensional extension) of the theory. We continue the study of quantum dimensions, associated with hypercube vertices, in the drastically simplified version of this approach to knot polynomials. At q=1 the problem is reformulated in terms of fat (ribbon) graphs, where Seifert cycles play the role of vertices. Ward identities in associated matrix model provide a set of recursions between classical dimensions. For q≠1 most of these relations are broken (i.e. deformed in a still uncontrollable way), and only few are protected by Reidemeister invariance of Chern–Simons theory. Still they are helpful for systematic evaluation of entire series of quantum dimensions, including negative ones, which are relevant for virtual link diagrams. To illustrate the effectiveness of developed formalism we derive explicit expressions for the 2-cabled HOMFLY of virtual trefoil and virtual 3.2 knot, which involve respectively 12 and 14 intersections – far beyond any dreams with alternative methods. As a more conceptual application, we describe a relation between the genus of fat graph and Turaev genus of original link diagram, which is currently the most effective tool for the search of thin knots
Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination

Inherited retinal dystrophies (iRDs) are a group of genetically and clinically heterogeneous conditions resulting from mutations in over 250 genes. Here, homozygosity mapping and whole-exome sequencing (WES) in a consanguineous family revealed a homozygous missense mutation, c.973C>T (p.His325Tyr), in RCBTB1. In affected individuals, it was found to segregate with retinitis pigmentosa (RP), goiter, primary ovarian insufficiency, and mild intellectual disability. Subsequent analysis of WES data in different cohorts uncovered four additional homozygous missense mutations in five unrelated families in whom iRD segregates with or without syndromic features. Ocular phenotypes ranged from typical RP starting in the second decade to chorioretinal dystrophy with a later age of onset. The five missense mutations affect highly conserved residues either in the sixth repeat of the RCC1 domain or in the BTB1 domain. A founder haplotype was identified for mutation c.919G>A (p.Val307Met), occurring in two families of Mediterranean origin. We showed ubiquitous mRNA expression of RCBTB1 and demonstrated predominant RCBTB1 localization in human inner retina. RCBTB1 was very recently shown to be involved in ubiquitination, more specifically as a CUL3 substrate adaptor. Therefore, the effect on different components of the CUL3 and NFE2L2 (NRF2) pathway was assessed in affected individuals’ lymphocytes, revealing decreased mRNA expression of NFE2L2 and several NFE2L2 target genes. In conclusion, our study puts forward mutations in RCBTB1 as a cause of autosomal-recessive non-syndromic and syndromic iRD. Finally, our data support a role for impaired ubiquitination in the pathogenetic mechanism of RCBTB1 mutations
Impact of Body Parameters on Dynamic Movement Primitives for Robot Control

AbstractThe problem of movement coordination in large DoF (Degree of Freedom) robots is complex due to redundancies. In this regard, Dynamic Movement Primitive (DMP) is a useful planning technique, inspired by biology, that can be used to store and reproduce trajectories about every DoF. This work is a preliminary study that aims to understand and quantify the influence of the robot dynamics upon the performance of DMP in a simulated 2DoF robot arm. The investigation demonstrates that the effect of the robot body dynamics needs to be taken into account during the learning process of the DMP
Continuum of Vasodilator Stress From Rest to Contrast Medium to Adenosine Hyperemia for Fractional Flow Reserve Assessment

AbstractObjectivesThis study compared the diagnostic performance with adenosine-derived fractional flow reserve (FFR) ≤0.8 of contrast-based FFR (cFFR), resting distal pressure (Pd)/aortic pressure (Pa), and the instantaneous wave-free ratio (iFR).BackgroundFFR objectively identifies lesions that benefit from medical therapy versus revascularization. However, FFR requires maximal vasodilation, usually achieved with adenosine. Radiographic contrast injection causes submaximal coronary hyperemia. Therefore, intracoronary contrast could provide an easy and inexpensive tool for predicting FFR.MethodsWe recruited patients undergoing routine FFR assessment and made paired, repeated measurements of all physiology metrics (Pd/Pa, iFR, cFFR, and FFR). Contrast medium and dose were per local practice, as was the dose of intracoronary adenosine. Operators were encouraged to perform both intracoronary and intravenous adenosine assessments and a final drift check to assess wire calibration. A central core lab analyzed blinded pressure tracings in a standardized fashion.ResultsA total of 763 subjects were enrolled from 12 international centers. Contrast volume was 8 ± 2 ml per measurement, and 8 different contrast media were used. Repeated measurements of each metric showed a bias <0.005, but a lower SD (less variability) for cFFR than resting indexes. Although Pd/Pa and iFR demonstrated equivalent performance against FFR ≤0.8 (78.5% vs. 79.9% accuracy; p = 0.78; area under the receiver-operating characteristic curve: 0.875 vs. 0.881; p = 0.35), cFFR improved both metrics (85.8% accuracy and 0.930 area; p < 0.001 for each) with an optimal binary threshold of 0.83. A hybrid decision-making strategy using cFFR required adenosine less often than when based on either Pd/Pa or iFR.ConclusionscFFR provides diagnostic performance superior to that of Pd/Pa or iFR for predicting FFR. For clinical scenarios or health care systems in which adenosine is contraindicated or prohibitively expensive, cFFR offers a universal technique to simplify invasive coronary physiological assessments. Yet FFR remains the reference standard for diagnostic certainty as even cFFR reached only ∼85% agreement
Biomarker discovery in asthma and COPD: Application of proteomics techniques in human and mice

AbstractThe use of advanced proteomics approaches in the search for biomarkers in chronic lung diseases, such as asthma and COPD, is rather limited. Asthma and COPD are complex disorders, which can be subdivided into several phenotypes. This results in a heterogeneity of differential expressed biological molecules. Furthermore, genetic differences between animals and humans make ‘translation’ of possible biomarkers challenging. Yet, the improved sensitivity and high throughput of proteomic techniques could be an important asset for (new) protein biomarker discovery in either human or animal models. We have reviewed the literature that reported the use of different proteomics approaches performed on samples obtained from humans and murine models in asthma and COPD research for the discovery of new biomarkers of diseases, biomarkers of sensitization or for the refinement of treatment. There is an increasing trend in the use of proteomics to explore new biomarkers of asthma or COPD. Although several murine models have been developed to study these lung diseases, and proteomics studies have been performed, ‘translation’ of identified candidate biomarkers into clinical studies is often lacking
Search for excited quarks in the γ+jet final state in proton–proton collisions at s=8 TeV

AbstractA search for excited quarks decaying into the γ+jet final state is presented. The analysis is based on data corresponding to an integrated luminosity of 19.7 fb−1 collected by the CMS experiment in proton–proton collisions at s=8 TeV at the LHC. Events with photons and jets with high transverse momenta are selected and the γ+jet invariant mass distribution is studied to search for a resonance peak. The 95% confidence level upper limits on the product of cross section and branching fraction are evaluated as a function of the excited quark mass. Limits on excited quarks are presented as a function of their mass and coupling strength; masses below 3.5 TeV are excluded at 95% confidence level for unit couplings to their standard model partners
Intercropping leek (Allium porrum L.) with dyer’s woad (Isatis tinctoria L.) increases rooted zone and agro-ecosystem retention of nitrogen

AbstractNitrate leaching can be high in organic vegetable production. Late-harvested crops like leek limit the use of autumn catch crops. The aim of this study was to investigate the growing of a combination of a deep-rooted catch crop and a shallow-rooted vegetable to reduce the risk of nitrate leaching. We compared a leek sole crop (S) with two intercropped systems of leek and early-sown dyer’s woad (five weeks after leek planting) (IE) or late-sown dyer’s woad (eight weeks after leek planting) (IL) in two seasons: 2012 and 2013. To reveal root and resource competition, leek with dyer’s woad rows left empty (Semp), and early and late-sown dyer’s woad with leek rows left empty (DEemp, DLemp) were included. Yield, dry above-ground biomass, aboveground N accumulation and soil inorganic N (Ninorg) were measured as well as root growth by use of minirhizotrons to 2.3m soil depth. Results showed that the marketable yield of leek in IE and IL systems was comparable with the yield in the S system when calculated per length of leek row. The Relative Competition Index (RCI) revealed that interspecific competition facilitated the growth of leek but hampered that of dyer’s woad. The rooted zone increased from 0.5m in the S system to more than 2m depth in those of the intercropped systems. Dyer’s woad ceased growing above ground but kept growing below ground after crop harvest and extended roots under the leek root system in 2012. Intercropping increased the root intensity of late-sown dyer’s woad after leek harvest in the 0.75–1.75m soil layer compared to dyer’s woad growing alone (DLemp), while the root depth was not affected. The intercropped system with early-sown dyer’s woad reduced soil Ninorg by 52kgha−1 relative to the sole-cropped system, and dyer’s woad accumulated 48kgNha−1 in aboveground biomass at harvest in 2013. Late-sown dyer’s woad had fewer roots, left higher soil Ninorg and had lower aboveground N accumulation than early-sown dyer’s woad until the following spring. Therefore, early-sown dyer’s woad is applicable in an organic intercropped system with high yields of leek to decrease the risk of nitrate leaching
On the boundaries of quantum integrability for the spin-1/2 Richardson–Gaudin system

AbstractWe discuss a generalised version of Sklyanin's Boundary Quantum Inverse Scattering Method applied to the spin-1/2, trigonometric sl(2) case, for which both the twisted-periodic and boundary constructions are obtained as limiting cases. We then investigate the quasi-classical limit of this approach leading to a set of mutually commuting conserved operators which we refer to as the trigonometric, spin-1/2 Richardson–Gaudin system. We prove that the rational limit of the set of conserved operators for the trigonometric system is equivalent, through a change of variables, rescaling, and a basis transformation, to the original set of trigonometric conserved operators. Moreover, we prove that the twisted-periodic and boundary constructions are equivalent in the trigonometric case, but not in the rational limit
Absence of U(1) Anomalous Superamplitudes in $\mathcal{N}\geq 5$
  Supergravities

We list all potential candidates for U(1) anomalous non-local 1-loop 4-point
amplitudes and higher loop UV divergences in $\mathcal{N}\geq 5$
supergravities. The relevant chiral superinvariants are constructed from
linearized chiral superfields and define the corresponding superamplitudes. The
anomalous amplitudes, of the kind present in $\mathcal{N}=4$, are shown to be
absent in $\mathcal{N} \geq 5$. In $\mathcal{N}=6$ supergravity the result is
deduced from the double-copy $\mathcal{N}=4_{YM} \times (\mathcal{N}=2)_{YM}$
model, whereas in $\mathcal{N}=5,8$ the result on absence of anomalous
amplitudes is derived in supergravities as well as in the $(\mathcal{N}=4)_{YM}
\times (\mathcal{N}-4)_{YM}$ double-copy models.Comment: 32 pages, v2:typo corrected, reference added, v3:typos correcte
Proton irradiation of CdTe thin film photovoltaics deposited on\ud
cerium‐doped space glass

Space photovoltaics is dominated by multi‐junction (III‐V) technology. However, emerging applications\ud
will require solar arrays with high specific power (kW/kg), flexibility in stowage and\ud
deployment, and a significantly lower cost than the current III‐V technology offers. This research\ud
demonstrates direct deposition of thin film CdTe onto the radiation‐hard cover glass that is normally\ud
laminated to any solar cell deployed in space. Four CdTe samples, with 9 defined contact\ud
device areas of 0.25 cm2, were irradiated with protons of 0.5‐MeV energy and varying fluences.\ud
At the lowest fluence, 1 × 1012 cm−2, the relative efficiency of the solar cells was 95%. Increasing\ud
the proton fluence to 1 × 1013 cm−2 and then 1 × 1014 cm−2 decreased the solar cell efficiency to\ud
82% and 4%, respectively. At the fluence of 1 × 1013 cm−2, carrier concentration was reduced by\ud
an order of magnitude. Solar Cell Capacitance Simulator (SCAPS) modelling obtained a good fit\ud
from a reduction in shallow acceptor concentration with no change in the deep trap defect concentration.\ud
The more highly irradiated devices resulted in a buried junction characteristic of the\ud
external quantum efficiency, indicating further deterioration of the acceptor doping. This is\ud
explained by compensation from interstitial H+ formed by the proton absorption. An anneal of\ud
the 1 × 1014 cm−2 fluence devices gave an efficiency increase from 4% to 73% of the pre‐irradiated\ud
levels, indicating that the compensation was reversible. CdTe with its rapid recovery through\ud
annealing demonstrates a radiation hardness to protons that is far superior to conventional multijunction\ud
III‐V solar cells