pinecone/core-2020-05-10-deduplication huggingface dataset:
Exploring the crowded central region of ten Galactic globular clusters using EMCCDs. Variable star searches and new discoveries

Aims: We aim to obtain time-series photometry of the very crowded central regions of Galactic globular clusters; to obtain better angular resolution than has been previously achieved with conventional CCDs onground-based telescopes; and to complete, or improve, the census of the variable star population in those stellar systems. Methods: Images were taken using the Danish 1.54-m Telescope at the ESO observatory at La Silla in Chile. The telescope was equipped with an electron-multiplying CCD, and the short-exposure-time images obtained (ten images per second) were stacked using the shift-and-add technique to produce the normal-exposure-time images (minutes). Photometry was performed via difference image analysis. Automatic detection of variable stars in the field was attempted. Results: The light curves of 12541 stars in the cores of ten globular clusters were statistically analysed to automatically extract the variable stars. We obtained light curves for 31 previously known variable stars (3 long-period irregular,2 semi-regular, 20 RR Lyrae, 1 SX Phoenicis, 3 cataclysmic variables, 1W Ursae Majoris-type and 1 unclassified) and we discovered 30 new variables (16 long-period irregular, 7 semi-regular, 4 RR Lyrae, 1 SX Phoenicis and 2 unclassified). Fluxes and photometric measurements for these stars are available in electronic form through the Strasbourg astronomical Data Center.Publisher PDFPeer reviewe
The phosphorylation of endogenous Nedd4-2 In Na+—absorbing human airway epithelial cells.

Neural precursor cell expressed, developmentally down-regulated protein 4-2 (Nedd4-2) mediates the internalisation / degradation of epithelial Na+ channel subunits (α-, β- and γ-ENaC). Serum / glucocorticoid inducible kinase 1 (SGK1) and protein kinase A (PKA) both appear to inhibit this process by phosphorylating Nedd4-2-Ser221, -Ser327 and -Thr246. This Nedd4-2 inactivation process is thought to be central to the hormonal control of Na+ absorption. The present study of H441 human airway epithelial cells therefore explores the effects of SGK1 and / or PKA upon the phosphorylation / abundance of endogenous Nedd4-2; the surface expression of ENaC subunits, and electrogenic Na+ transport. Effects on Nedd4-2 phosphorylation/abundance and the surface expression of ENaC were monitored by western analysis, whilst Na+ absorption was quantified electrometrically. Acutely (20 min) activating PKA in glucocorticoid-deprived (24 h) cells increased the abundance of Ser221-phosphorylated, Ser327-phosphorylated and total Nedd4-2 without altering the abundance of Thr246-phosphorylated Nedd4-2. Activating PKA under these conditions did not cause a co-ordinated increase in the surface abundance of α-, β- and γ-ENaC and had only a very small effect upon electrogenic Na+ absorption. Activating PKA (20 min) in glucocorticoid-treated (0.2 µM dexamethasone, 24 h) cells, on the other hand, increased the abundance of Ser221-, Ser327- and Thr246-phosphorylated and total Nedd4-2; increased the surface abundance of α-, β- and γ-ENaC and evoked a clear stimulation of Na+ transport. Chronic glucocorticoid stimulation therefore appears to allow cAMP-dependent control of Na+ absorption by facilitating the effects of PKA upon the Nedd4-2 and ENaC subunits
Intermediate scalings in holographic RG flows and conductivities.

We construct numerically finite density domain-wall solutions which interpolate between two AdS 4 fixed points and exhibit an intermediate regime of hyperscaling violation, with or without Lifshitz scaling. Such RG flows can be realized in gravitational models containing a dilatonic scalar and a massive vector field with appropriate choices of the scalar potential and couplings. The infrared AdS 4 fixed point describes a new ground state for strongly coupled quantum systems realizing such scalings, thus avoiding the well-known extensive zero temperature entropy associated with AdS2×R2. We also examine the zero temperature behavior of the optical conductivity in these backgrounds and identify two scaling regimes before the UV CFT scaling is reached. The scaling of the conductivity is controlled by the emergent IR conformal symmetry at very low frequencies, and by the intermediate scaling regime at higher frequencies
The Schr\"odinger Equation in the Mean-Field and Semiclassical Regime

In this paper, we establish (1) the classical limit of the Hartree equation
leading to the Vlasov equation, (2) the classical limit of the $N$-body linear
Schr\"{o}dinger equation uniformly in N leading to the N-body Liouville
equation of classical mechanics and (3) the simultaneous mean-field and
classical limit of the N-body linear Schr\"{o}dinger equation leading to the
Vlasov equation. In all these limits, we assume that the gradient of the
interaction potential is Lipschitz continuous. All our results are formulated
as estimates involving a quantum analogue of the Monge-Kantorovich distance of
exponent 2 adapted to the classical limit, reminiscent of, but different from
the one defined in [F. Golse, C. Mouhot, T. Paul, Commun. Math. Phys. 343
(2016), 165-205]. As a by-product, we also provide bounds on the quadratic
Monge-Kantorovich distances between the classical densities and the Husimi
functions of the quantum density matrices.Comment: 33 page
Measurement of the CP-violating phase $\phi_s$ and the $B^0_s$ meson
  decay width difference with $B^0_s \to J/\psi\phi$ decays in ATLAS

A measurement of the $B^0_s$ decay parameters in the $B^0_s \to J/\psi\phi$
channel using an integrated luminosity of 14.3 $\mathrm{fb}^{-1}$ collected by
the ATLAS detector from 8 TeV $pp$ collisions at the LHC is presented. The
measured parameters include the $CP$-violating phase $\phi_s$, the decay width
$\Gamma_s$ and the width difference between the mass eigenstates
$\Delta\Gamma_s$. The values measured for the physical parameters are
statistically combined with those from 4.9 $\mathrm{fb}^{-1}$ of 7 TeV data,
leading to the following: \begin{eqnarray*} \phi_s & = & -0.090 \pm
0.078\;\mathrm{(stat.)} \pm 0.041\;\mathrm{(syst.)\;rad} \\ \Delta\Gamma_s & =
& 0.085 \pm 0.011\;\mathrm{(stat.)} \pm 0.007\;\mathrm{(syst.)\;ps}^{-1} \\
\Gamma_s & = & 0.675 \pm 0.003\;\mathrm{(stat.)} \pm
0.003\;\mathrm{(syst.)\;ps}^{-1}. \end{eqnarray*} In the analysis the parameter
$\Delta\Gamma_s$ is constrained to be positive. Results for $\phi_s$ and
$\Delta\Gamma_s$ are also presented as 68% and 95% likelihood contours in the
$\phi_s-\Delta\Gamma_s$ plane. Also measured in this decay channel are the
transversity amplitudes and corresponding strong phases. All measurements are
in agreement with the Standard Model predictions.Comment: 27 pages plus author list (44 pages total), 10 figures, 8 tables,
  published version, all figures and tables are available at
  https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/BPHY-2014-03
Z/gamma* plus Multiple Hard Jets in High Energy Collisions

We present a description of the production of a di-lepton pair (through Z
boson and virtual photon) in association with at least two jets. This
calculation adds to the fixed-order accuracy the dominant logarithms in the
limit of large partonic centre-of-mass energy to all orders in the strong
coupling. This is achieved within the framework of High Energy Jets. This
calculation is made possible by extending the high energy treatment to take
into account the multiple t-channel exchanges arising from Z and
gamma*-emissions off several quark lines. The correct description of the
interference effects from the various t-channel exchanges requires an extension
of the subtraction terms in the all-order calculation. We describe this
construction and compare the resulting predictions to a number of recent
analyses of LHC data. The description of a wide range of observables is good,
and, as expected, stands out from other approaches in particular in the regions
of large dijet invariant mass and large dijet rapidity spans.Comment: 35 pages, 14 figures; v2: additional appendix discussing scale
  variation in normalised distributions plus additional comments on scale
  variation in section 4, matches published versio
Molecular tools for bathing water assessment in Europe: Balancing social science research with a rapidly developing environmental science evidence-base

This is the final version of the article. Available from the publisher via the DOI in this record.The use of molecular tools, principally qPCR, versus traditional culture-based methods for quantifying microbial parameters (e.g., Fecal Indicator Organisms) in bathing waters generates considerable ongoing debate at the science–policy interface. Advances in science have allowed the development and application of molecular biological methods for rapid (~2 h) quantification of microbial pollution in bathing and recreational waters. In contrast, culture-based methods can take between 18 and 96 h for sample processing. Thus, molecular tools offer an opportunity to provide a more meaningful statement of microbial risk to water-users by providing near-real-time information enabling potentially more informed decision-making with regard to water-based activities. However, complementary studies concerning the potential costs and benefits of adopting rapid methods as a regulatory tool are in short supply. We report on findings from an international Working Group that examined the breadth of social impacts, challenges, and research opportunities associated with the application of molecular tools to bathing water regulations.The Working Group and associated workshop
series were funded by the Natural Environment Research Council as
part of the Delivering Healthy Water project (NE/I022191/1). LF
received funding in part by the European Regional Development
Fund Programme and the European Social Fund Convergence Programme
for Cornwall and the Isles of Scilly. Thanks are extended to
all participants who contributed to the online survey. Finally, the
constructive comments from two anonymous referees and the editor
helped to improve the overall quality of this manuscript
Non-invasive assessement of coronary flow velocity: Clinical and experimental studies

BACKGROUND AND OBJECTIVES
Coronary flow velocity (CFV) and coronary flow velocity reserve (CFVR)
evaluated by transthoracic ultrasound is a promising method to assess ischemic
heart disease. CFVR is the ratio between CFV during maximal hyperemia and
baseline. A reduced CFVR indicates an increased risk for cardiovascular events.
The aims of this thesis were 1. To evaluate the effect of nitroglycerine
administration on CFV and CFVR. 2. To investigate if CFVR provides prognostic
information about cardiovascular events, in addition to myocardial scintigraphy,
in patients with suspected coronary artery disease. 3. To investigate the
relationship between CFVR and significant coronary stenosis. 4. To assess the
effects of ticagrelor on CFV and dyspnea.
METHODS
In study I, CFV and CFVR and coronary artery diameter were assessed before and
after sublingual nitroglycerine administration in 26 healthy subjects. In study II,
CFVR was measured in 371 patients undergoing scintigraphy due to suspected
coronary artery disease. CFVR and scintigraphy results were related to
cardiovascular events (cardiovascular death, myocardial infarction, acute
revascularization) during a mean follow-up of 4.5 years. In study III, CFVR and
coronary angiograms were evaluated in 123 patients from study II (n=123).
Study IV was a double-blind placebo-controlled cross-over study randomizing 40
healthy subjects to ticagrelor or placebo. CFV and dyspnea were assessed at
baseline and during increasing doses of adenosine.
RESULTS
Nitroglycerine increased CFVR due to a reduction in baseline CFV. Adenosineinduced
CFV remained unchanged. A CFVR≤2 was independently associated with
cardiovascular event rate (adjusted hazard ratio 3.02 (1.51-6.04, p=0.002) and
added prognostic information in addition to scintigraphy. There was a significant
association between CFVR and the presence of coronary stenoses. Ticagrelor
augmented CFV and dyspnea during adenosine administration.
CONCLUSIONS
Nitroglycerine increases CFVR which indicates that adenosine alone causes a
submaximal hyperemia. The associations between CFVR and cardiovascular
events, and between CFVR and significant coronary stenosis supports routine
assessment with CFVR in patients with suspected ischemic heart disease. The
results indicate that adenosine is involved in the systemic effects of ticagrelor.
Keywords: ischemic heart disease, coronary flow velocity, ultrasoun
Prognostication in comatose survivors of cardiac arrest: An advisory statement from the European Resuscitation Council and the European Society of Intensive Care Medicine

Contains fulltext :
                  138933.pdf (publisher's version ) (Open Access)OBJECTIVES: To review and update the evidence on predictors of poor outcome (death, persistent vegetative state or severe neurological disability) in adult comatose survivors of cardiac arrest, either treated or not treated with controlled temperature, to identify knowledge gaps and to suggest a reliable prognostication strategy. METHODS: GRADE-based systematic review followed by expert consensus achieved using Web-based Delphi methodology, conference calls and face-to-face meetings. Predictors based on clinical examination, electrophysiology, biomarkers and imaging were included. RESULTS AND CONCLUSIONS: Evidence from a total of 73 studies was reviewed. The quality of evidence was low or very low for almost all studies. In patients who are comatose with absent or extensor motor response at >/=72 h from arrest, either treated or not treated with controlled temperature, bilateral absence of either pupillary and corneal reflexes or N20 wave of short-latency somatosensory evoked potentials were identified as the most robust predictors. Early status myoclonus, elevated values of neuron-specific enolase at 48-72 h from arrest, unreactive malignant EEG patterns after rewarming, and presence of diffuse signs of postanoxic injury on either computed tomography or magnetic resonance imaging were identified as useful but less robust predictors. Prolonged observation and repeated assessments should be considered when results of initial assessment are inconclusive. Although no specific combination of predictors is sufficiently supported by available evidence, a multimodal prognostication approach is recommended in all patients
Performance of jet substructure techniques for large-R jets in proton-proton collisions at root s=7 TeV using the ATLAS detector

This paper presents the application of a variety of techniques to study jet substructure. The performance of various modified jet algorithms, or jet grooming techniques, for several jet types and event topologies is investigated for jets with transverse momentum larger than 300 GeV. Properties of jets subjected to the mass-drop filtering, trimming, and pruning algorithms are found to have a reduced sensitivity to multiple proton-proton interactions, are more stable at high luminosity and improve the physics potential of searches for heavy boosted objects. Studies of the expected discrimination power of jet mass and jet substructure observables in searches for new physics are also presented. Event samples enriched in boosted W and Z bosons and top-quark pairs are used to study both the individual jet invariant mass scales and the efficacy of algorithms to tag boosted hadronic objects. The analyses presented use the full 2011 ATLAS dataset, corresponding to an integrated luminosity of 4.7 +/- 0.1 fb(-1) from proton-proton collisions produced by the Large Hadron Collider at a centre-of-mass energy of root s = 7 TeV
Homophily and Long Run Integration in Social Networks

We model network formation when heterogeneous nodes enter sequentially and form connections through both random meetings and network-based search, but with type-dependent biases. We show that there is “long-run integration”, whereby the composition of types in sufficiently old nodesʼ neighborhoods approaches the global type-distribution, provided that the network-based search is unbiased. However, younger nodesʼ connections still reflect the biased meetings process. We derive the type-based degree distributions and group-level homophily patterns when there are two types and location-based biases. Finally, we illustrate aspects of the model with an empirical application to data on citations in physics journals
Dynamic Force Spectroscopy on Supported Lipid Bilayers: Effect ofTemperature and Sample Preparation

Biological membranes are constantly exposed to forces. The stress-strain relation in membranes determines thebehavior of many integral membrane proteins or other membrane related-proteins that show a mechanosensitive behavior. Here, we studied by force spectroscopy the behavior of supported lipid bilayers (SLBs) subjected to forces perpendicular to their plane. We measured the lipid bilayer mechanical properties and the force required for the punch-through event characteristic of atomic force spectroscopy on SLBs as a function of the interleaflet coupling. We found that for an uncoupled bilayer, the overall tip penetration occurs sequentially through the two leaflets, giving rise to two penetration events. In the case of a bilayer with coupled leaflets, penetration of the atomic force microscope tip always occurred in a single step. Considering the dependence of the jump-through force value on the tip speed, we also studied the process in the context of dynamic force spectroscopy (DFS). We performed DFS experiments by changing the temperature and cantilever spring constant, and analyzed the resultsin the context of the developed theories for DFS. We found that experiments performed at different temperatures and withdifferent cantilever spring constants enabled a more effective comparison of experimental data with theory in comparisonwith previously published data
La2010: a new orbital solution for the long-term motion of the Earth

Published in Astronomy and Astrophysics. Reproduced with permission. Copyright ESO.International audienceWe present here a new solution for the astronomical computation of the orbital motion of the Earth spanning from 0 to −250 Myr. The main improvement with respect to our previous numerical solution La2004 is an improved adjustment of the parameters and initial conditions through a fit over 1 Myr to a special version of the highly accurate numerical ephemeris INPOP08 (Intégration Numérique Planétaire de l'Observatoire de Paris). The precession equations have also been entirely revised and are no longer averaged over the orbital motion of the Earth and Moon. This new orbital solution is now valid over more than 50 Myr in the past or into the future with proper phases of the eccentricity variations. Owing to the chaotic behavior, the precision of the solution decreases rapidly beyond this time span, and we discuss the behavior of various solutions beyond 50 Myr. For paleoclimate calibrations, we provide several different solutions that are all compatible with the most precise planetary ephemeris. We have thus reached the time where geological data are now required to discriminate between planetary orbital solutions beyond 50 Myr
Confined optical vibrations in CdTe quantum dots and clusters

Absorption of far-infrared (FIR) radiation and Raman scattering in CdTe nano-crystals (spherical quantum dots (QDs) of several nanometers in size) and Cd54Te32(SCH2CH2OH)8- 32 clusters prepared
by colloidal synthesis were studied. Raman spectra of both QDs and clusters are dominated by a peak situated slightly below the bulk CdTe LO phonon frequency. Experimental FIR transmittance
spectra of films containing CdTe clusters show a broad band between the bulk TO and LO phonon frequencies, while there is only a single dip at the Fro¨ hlich frequency observed for larger QDs. These observations are in agreement with the results of our numerical lattice dynamics calculations
and previously published theoretical results based on a continuous model. It is suggested that the lattice dynamics of very small clusters is similar to that of large crystallites in the sense that there still exists the dispersion of optical vibration frequencies within the LO–TO band of bulk material.Fundação para a Ciência e a Tecnologia (FCT
Resource savings by urban mining : the case of desktop and laptop computers in Belgium

Waste electrical and electronic equipment (WEEE) has become increasingly important over the last years. Additionally, the European Union recognizes the growing importance of raw materials, and the crucial role of recycling. In this study the performance of WEEE recycling was assessed for the case of desktop and laptop computers in Belgium in 2013. The analysis was performed in four steps. First, the recycling chain is analyzed through material flow analysis (MFA) at the level of specific materials. Second, an indicator is calculated, which quantifies the effectively recycled weight ratios of the specific materials. Third, a second indicator expresses the recycling efficiency of so-called critical raw materials. Finally, the natural resource consumption of the recycling scheme in a life cycle perspective is calculated using the Cumulative Exergy Extraction from the Natural Environment (CEENE) method, and is benchmarked with a landfill scenario. Overall, the results show that base metals such as ferrous metals, aluminium and copper are recycled to a large extent, but that for precious metals improvements still can be made. The input of criticality (arising from the incoming mass, as well as the individual criticality value of the assessed material) mainly comes from base metals, resulting in a high recovery performance of raw materials criticality. Finally, the natural resource consumption of the recycling scenario is much smaller than in case of landfilling the WEEE: 80 and 87% less resource consumption is achieved for desktops and laptops respectively, hence saving significant primary raw materials
Search for the Standard Model Higgs boson decaying into bb¯¯ produced in association with top quarks decaying hadronically in pp collisions at s√=8 TeV with the ATLAS detector

A search for Higgs boson production in association with a pair of top quarks (tt¯H) is performed, where the Higgs boson decays to bb¯¯, and both top quarks decay hadronically. The data used correspond to an integrated luminosity of 20.3 fb−1 of pp collisions at s√=8 TeV collected with the ATLAS detector at the Large Hadron Collider. The search selects events with at least six energetic jets and uses a boosted decision tree algorithm to discriminate between signal and Standard Model background. The dominant multijet background is estimated using a dedicated data-driven technique. For a Higgs boson mass of 125 GeV, an upper limit of 6.4 (5.4) times the Standard Model cross section is observed (expected) at 95% confidence level. The best-fit value for the signal strength is μ = 1.6 ± 2.6 times the Standard Model expectation for m H = 125 GeV. Combining all tt¯H searches carried out by ATLAS at s√=8 and 7 TeV, an observed (expected) upper limit of 3.1 (1.4) times the Standard Model expectation is obtained at 95% confidence level, with a signal strength μ = 1.7 ± 0.8