pinecone/core-2020-05-10-deduplication huggingface dataset:
Relevance Evaluation of Engineering Master's Program in Peru

AbstractIn a context of mass higher education, it is necessary to ensure not only quality but also the relevance of engineering master's programs, namely the appropriateness of the objectives and outcomes to the needs and interests of the program beneficiaries. After a literature review we analyzed the evaluation models of three organizations in Peru: the Board of Evaluation, Accreditation and Certification of the University Education Quality – CONEAU, the Institute of Quality and Accreditation of Computing, Engineering and Technology - ICACIT and the Pontificia Universidad Catolica del Peru. The result of this study is a model for relevance evaluation for an engineering masteŕs program in Peru
Radiative breaking of the minimal supersymmetric left–right model

AbstractWe study a variation to the SUSY Left–Right symmetric model based on the gauge group SU(3)c×SU(2)L×SU(2)R×U(1)BL. Beyond the quark and lepton superfields we only introduce a second Higgs bidoublet to produce realistic fermion mass matrices. This model does not include any SU(2)R triplets. We calculate renormalization group evolutions of soft SUSY parameters at the one-loop level down to low energy. We find that an SU(2)R slepton doublet acquires a negative mass squared at low energies, so that the breaking of SU(2)R×U(1)BL→U(1)Y is realized by a non-zero vacuum expectation value of a right-handed sneutrino. Small neutrino masses are produced through neutrino mixings with gauginos. Mass limits on the SU(2)R×U(1)BL sector are obtained by direct search results at the LHC as well as lepton-gaugino mixing bounds from the LEP precision data
Quark CP-phase and Froggatt–Nielsen mechanism

AbstractOn the basis of the Froggatt–Nielsen mechanism, we study quark flavor mixings in the SU(6)×SU(2)R model. The characteristic structure of the CKM matrix is attributed to the hierarchical effective Yukawa couplings due to the Froggatt–Nielsen mechanism and also to the state-mixings beyond the MSSM. We elucidate the detailed form of the CKM matrix elements and find interesting relations between the CP violating phase and three mixing angles. Taking the existing data of three mixing angles, we estimate the quark CP-phase at δ=(75±3)°. This result is in accord with observations
Dark matter self-interactions via collisionless shocks in cluster mergers

AbstractWhile dark matter self-interactions may solve several problems with structure formation, so far only the effects of two-body scatterings of dark matter particles have been considered. We show that, if a subdominant component of dark matter is charged under an unbroken U(1) gauge group, collective dark plasma effects need to be taken into account to understand its dynamics. Plasma instabilities can lead to collisionless dark matter shocks in galaxy cluster mergers which might have been already observed in the Abell 3827 and 520 clusters. As a concrete model we propose a thermally produced dark pair plasma of vector-like fermions. In this scenario the interacting dark matter component is expected to be separated from the stars and the non-interacting dark matter halos in cluster collisions. In addition, the missing satellite problem is softened, while constraints from all other astrophysical and cosmological observations are avoided
Chirally motivated K− nuclear potentials

AbstractIn-medium subthreshold K¯N scattering amplitudes calculated within a chirally motivated meson–baryon coupled-channel model are used self consistently to confront K− atom data across the periodic table. Substantially deeper K− nuclear potentials are obtained compared to the shallow potentials derived in some approaches from threshold K¯N amplitudes, with ReVK−chiral=−(85±5) MeV at nuclear matter density. When K¯NN contributions are incorporated phenomenologically, a very deep K− nuclear potential results, ReVK−chiral+phen.=−(180±5) MeV, in agreement with density dependent potentials obtained in purely phenomenological fits to the data. Self consistent dynamical calculations of K−–nuclear quasibound states generated by VK−chiral are reported and discussed
The Classic: Bone Morphogenetic Protein

This Classic Article is a reprint of the original work by Marshall R. Urist and Basil S. Strates, Bone Morphogenetic Protein. An accompanying biographical sketch of Marshall R. Urist, MD is available at DOI 10.1007/s11999-009-1067-4; a second Classic Article is available at DOI 10.1007/s11999-009-1069-2; and a third Classic Article is available at DOI 10.1007/s11999-009-1070-9. The Classic Article is © 1971 by Sage Publications Inc. Journals and is reprinted with permission from Urist MR, Strates BS. Bone morphogenetic protein. J Dent Res. 1971;50:1392–1406
Shared values and deliberative valuation: Future directions

Valuation that focuses only on individual values evades the substantial collective and intersubjective meanings, significance and value from ecosystems. Shared, plural and cultural values of ecosystems constitute a diffuse and interdisciplinary field of research, covering an area that links questions around value ontology, elicitation and aggregation with questions of participation, ethics, and social justice. Synthesising understanding from various contributions to this Special Issue of Ecosystem Services, and with a particular focus on deliberation and deliberative valuation, we discuss key findings and present 35 future research questions in eight topic areas: 1) the ontology of shared values; 2) the role of catalyst and conflict points; 3) shared values and cultural ecosystem services; 4) transcendental values; 5) the process and outcomes of deliberation; 6) deliberative monetary valuation; 7) value aggregation, meta-values and 'rules of the game'; and 8) integrating valuation methods. The results of this Special Issue and these key questions can help develop a more extensive evidence base to mature the area and develop environmental valuation into a more pluralistic, comprehensive, robust, legitimate and effective way of safeguarding ecosystems and their services for the future
Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver.

Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulation at the transcriptional level, much less is known about temporally controlled functions within the nucleus and their regulation at the protein level. Here, we quantified the temporal nuclear accumulation of proteins and phosphoproteins from mouse liver by SILAC proteomics. We identified around 5,000 nuclear proteins, over 500 of which showed a diurnal accumulation. Parallel analysis of the nuclear phosphoproteome enabled the inference of the temporal activity of kinases accounting for rhythmic phosphorylation. Many identified rhythmic proteins were parts of nuclear complexes involved in transcriptional regulation, ribosome biogenesis, DNA repair, and the cell cycle and its potentially associated diurnal rhythm of hepatocyte polyploidy. Taken together, these findings provide unprecedented insights into the diurnal regulatory landscape of the mouse liver nucleus
Planck 2015 results: IX. Diffuse component separation: CMB maps

We present foreground-reduced cosmic microwave background (CMB) maps derived from the full Planck data set in both temperature and polarization. Compared to the corresponding Planck 2013 temperature sky maps, the total data volume is larger by a factor of 3.2 for frequencies between 30 and 70 GHz, and by 1.9 for frequencies between 100 and 857 GHz. In addition, systematic errors in the forms of temperature-to-polarization leakage, analogue-to-digital conversion uncertainties, and very long time constant errors have been dramatically reduced, to the extent that the cosmological polarization signal may now be robustly recovered on angular scales ℓ ≳ 40. On the very largest scales, instrumental systematic residuals are still non-negligible compared to the expected cosmological signal, and modes with ℓ< 20 are accordingly suppressed in the current polarization maps by high-pass filtering. As in 2013, four different CMB component separation algorithms are applied to these observations, providing a measure of stability with respect to algorithmic and modelling choices. The resulting polarization maps have rms instrumental noise ranging between 0.21 and 0.27μK averaged over 55' pixels, and between 4.5 and 6.1μK averaged over 3.4 parcm pixels. The cosmological parameters derived from the analysis of temperature power spectra are in agreement at the 1σ level with the Planck 2015 likelihood. Unresolved mismatches between the noise properties of the data and simulations prevent a satisfactory description of the higher-order statistical properties of the polarization maps. Thus, the primary applications of these polarization maps are those that do not require massive simulations for accurate estimation of uncertainties, for instance estimation of cross-spectra and cross-correlations, or stacking analyses. However, the amplitude of primordial non-Gaussianity is consistent with zero within 2σ for all local, equilateral, and orthogonal configurations of the bispectrum, including for polarization E-modes. Moreover, excellent agreement is found regarding the lensing B-mode power spectrum, both internally among the various component separation codes and with the best-fit Planck 2015 Λ cold dark matter model
First observation of the decay B0s → D0K*0 and a measurement of the ratio of branching fractions B (B0s → D0K*0) / B (B0s → D0ρ0

The first observation of the decay $\bar{B}^0_s \to D^0 K^{*0}$ using $pp$ data collected by the LHCb detector at a centre-of-mass energy of 7 TeV, corresponding to an integrated luminosity of 36 pb$^{-1}$, is reported. A signal of $34.4 \pm 6.8$ events is obtained and the absence of signal is rejected with a statistical significance of more than nine standard deviations. The $\bar{B}^0_s \to D^0 K^{*0}$ branching fraction is measured relative to that of $\bar{B}^0 \to D^0 \rho^0$: $\frac{{\cal B}(\bar{B}^0_s \to D^0 K^{*0})}{{\cal B}(\bar{B}^0 \to D^0 \rho^0)} = 1.48 \pm 0.34 \pm 0.15 \pm 0.12$, where the first uncertainty is statistical, the second systematic and the third is due to the uncertainty on the ratio of the $B^0$ and $B^0_s$ hadronisation fractions
GDP Growth and Credit Data

It is a well-known fact that there is a strong relationship between bank credits and economic activity. Thus, it is a reasonable question whether credit data can be used in nowcasting GDP growth.  It is important for policymakers to make on-time decisions with the most available data and nowcasting is an important tool when policies in question are needed to be made based on current figures. Most macroeconomic variables are made available to public after a considerable delay; however, banking credit data may be very valuable for the early estimate of current GDP as it is available only with a few days delay. In this paper, we aim to investigate the feasibility of using credit data in explaining the variability in Turkish GDP growth and as well as nowcasting it. For this purpose, we use credit impulse and new borrowing, two measures of credit flows. We show that credit impulse and new borrowing are significant in explaining the pattern of the Turkish GDP growth and they have significant contribution to nowcasting it.
Ultrasound-assisted swelling of bacterial cellulose

Bacterial cellulose (BC) was obtained by static cultivation using commercial BC gel from scoby. BC membranes (oven dried and freeze-dried) were swelled with 8% NaOH, in absence and in presence of ultrasound (US), for 30, 60 and 90 min. The influence of swelling conditions on both physico-chemical properties and molecules entrapment was evaluated. Considering the highest levels of entrapment, an optimum swelling procedure was established: 8% NaOH for 30 min. at room temperature in the presence of US. Native and PEGylated laccase from Myceliophthora Thermophila was immobilized on BC membranes and a different catalytic behaviour was observed after immobilization. Native laccase presented activity values similar to published reports (5-7 U/gBC) after immobilization whereas PEGylated enzymes showed much lower activity (1-2 U/gBC). BC swelled membranes are presented herein as a potential support for the preparation of immobilized enzymes for industrial applications, like phenolics polymerization.The authors would like to acknowledge Portuguese Foundation for Science and Technology (FCT)under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI01-0145-FEDER-006684) and BioTecNorte operation (NORTE01-0145-FEDER-000004) funded by European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. The authors would like also to acknowledge the Basic Science Research Program through the National Research Foundation of Korea (NRF), which was funded by the Ministry of Education (2015R1D1A1A01060747). This work also received funding from the European Union Horizon 2020 research and innovation programme under grant agreement NMP-06-2015-683356 FOLSMART.info:eu-repo/semantics/publishedVersio
CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to 191,161 adult samples from 26 cohorts. The study reveals five CNV associations at 1q21.1, 3q29, 7q11.23, 11p14.2, and 18q21.32 and confirms two known loci at 16p11.2 and 22q11.21, implicating at least one anthropometric trait. The discovered CNVs are recurrent and rare (0.01–0.2%), with large effects on height (>2.4 cm), weight (>5 kg), and body mass index (BMI) (>3.5 kg/m2). Burden analysis shows a 0.41 cm decrease in height, a 0.003 increase in waist-to-hip ratio and increase in BMI by 0.14 kg/m2 for each Mb of total deletion burden (P = 2.5 × 10−10, 6.0 × 10−5, and 2.9 × 10−3). Our study provides evidence that the same genes (e.g., MC4R, FIBIN, and FMO5) harbor both common and rare variants affecting body size and that anthropometric traits share genetic loci with developmental and psychiatric disorders.Peer-reviewedPublisher Versio
Polarization dependence of the fundamental absorption edge and the Urbach rule in PbMoO4 crystals

This is the pre-peer reviewed version of the following article: Fujita M. and Itoh. M. Polarization dependence of the fundamental absorption edge and the Urbach rule in PbMoO4 crystals. physica status solidi (b). 247(9), 2240-2243, 2010, which has been published in final form at http://dx.doi.org/10.1002/pssb.201046034The fundamental absorption tail of PbMoO4 crystals has been investigated in the ac plane in a wide temperature range between 6 and 300 K by using linearly polarized light. A remarkable dichroism between E//a and E//c is observed in the tail region. A defect-related absorption band is clarified for the polarization E//a. It is found that the Urbach rule holds for the absorption spectra measured with light polarized with E//c. The results of the analysis of the Urbach tail are discussed in comparison with the experimental results on the exciton transition and luminescence properties in this material
Engaging with energy reduction : does a climate change frame have the potential for achieving broader sustainable behaviour?

Reducing energy use is key in meeting ambitious climate change targets being set around the world. This research considers the psychological impact, and potential for behavioural spillover, resulting from receiving energy information framed in terms of financial costs or the environment. We utilised an online tool in order to present undergraduate participants with an energy display simulation of their own energy use and presented energy use in terms of kilowatt-hours, carbon dioxide (CO2), or costs. Study 1 found increased motivations to save energy for climate change reasons and some indications that environmental behaviour might increase after participants received CO2 information compared to alternatives. Study 2 found that CO2 information increased climate change salience, which mediated effects observed on environmental behaviour intentions. Data suggest that highlighting climate change in relation to energy savings may be useful for promoting broader environmental behaviour
Phenolic profile and effect of regular consumption of Brazilian red wines on\ud
in vivo antioxidant activity

In this study, Vitis vinifera L wines cv. Cabernet Franc, Merlot, Sangiovese and Syrah, 2006 and 2007 vintages, produced in Sa˜o Joaquim, a new wine-producing region in southern Brazil, were evaluated. As phenolic compound content is one of the most important parameters in assessing wine quality and is possibly partially responsible for the beneficial health properties of wines, in this paper the levels of the main anthocyanins, flavonols, hydroxycinnamic acid and hydroxybenzoic acid (HPLC-DAD and HPLCDAD–MS analysis) and the in vivo antioxidant activity in mice are reported. The antioxidant capacity of plasma was assessed through the reduction of ferric iron (FRAP). Lipid peroxidation (TBARS), carbonyl protein (CP), reduced glutathione (GSH) levels and the catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity were determined in livers of the test animals. The results for the phenolic compounds content of the wine samples were considered appropriate for quality red wines, and the wine consumption promoted a significant increase in FRAP and decreases in the TBARS and CP levels and in the CAT, SOD and GPx activity. Moreover, the phenolic content of the wines was positively\ud
correlated with the in vivo antioxidant capacity promoted by regular wine consumptio
Gut microbiota functions: metabolism of nutrients and other food components

The diverse microbial community that inhabits the human gut has an extensive metabolic repertoire that is distinct from, but complements the activity of mammalian enzymes in the liver and gut mucosa and includes functions essential for host digestion. As such, the gut microbiota is a key factor in shaping the biochemical profile of the diet and, therefore, its impact on host health and disease. The important role that the gut microbiota appears to play in human metabolism and health has stimulated research into the identification of specific microorganisms involved in different processes, and the elucidation of metabolic pathways, particularly those associated with metabolism of dietary components and some host-generated substances. In the first part of the review, we discuss the main gut microorganisms, particularly bacteria, and microbial pathways associated with the metabolism of dietary carbohydrates (to short chain fatty acids and gases), proteins, plant polyphenols, bile acids, and vitamins. The second part of the review focuses on the methodologies, existing and novel, that can be employed to explore gut microbial pathways of metabolism. These include mathematical models, omics techniques, isolated microbes, and enzyme assays
Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling

Contains fulltext :
                  182312.pdf (publisher's version ) (Open Access)TNF receptor superfamily members (TNFRSF) such as CD40, Fas and TRAIL receptor 2 (TRAILR2) participate to the adaptive immune response by eliciting survival, proliferation, differentiation and/or cell death signals. The balance between these signals determines the fate of the immune response. It was previously reported that these receptors are able to self-assemble in the absence of ligand through their extracellular regions. However, the role of this oligomerization is not well understood, and none of the proposed hypotheses take into account potential hetero-association of receptors. Using CD40 as bait in a flow cytometry Forster resonance energy transfer assay, TNFRSF members with known functions in B cells were probed for interactions. Both Fas and TRAILR2 associated with CD40. Immunoprecipitation experiments confirmed the interaction of CD40 with Fas at the endogenous levels in a BJAB B-cell lymphoma cell line deficient for TRAILR2. TRAILR2-expressing BJAB cells displayed a robust CD40-TRAILR2 interaction at the expense of the CD40-Fas interaction. The same results were obtained by proximity ligation assay, using TRAILR2-positive and -negative BJAB cells and primary human B cells. Expression of the extracellular domains of Fas or TRAILR2 with a glycolipid membrane anchor specifically reduced the intrinsic signalling pathway of CD40 in 293T cells. Conversely, BJAB cells lacking endogenous Fas or TRAILR2 showed an increased NF-kappaB response to CD40L. Finally, upregulation of TRAILR2 in primary human B cells correlated with reduced NF-kappaB activation and reduced proliferation in response to CD40L. Altogether, these data reveal that selective interactions between different TNFRSF members may modulate ligand-induced responses upstream signalling events
Default and Abandonment Option in Motorway Concessions

As long as motorway concessions are subject to the variability of traffic demand, it is necessary to apply valuation methods that can take into account that uncertainty. In the past, many concession projects have faced an early termination of the contract due to lower traffic than expected. These insolvency situations raise the issue of the compensation to the concessionaire when the contract is prematurely terminated. A methodology based on the real-options approach has been developed in this paper to assess insolvency situations in motorway concessions. Under this approach, the mechanism of compensation can be modeled as an abandonment option, granted by the public administration to the concessionaire, in which the value of the option will depend on the evolution of traffic. This methodology is then applied to the case of a real concession in Spain. The results show a significant value of the abandonment option, which represents an implicit aid from the public administration to the concession. In this way, the methodology presented in this paper can contribute to gaining a better understanding of the risks of motorway concessions and enhancing the transparency in concession contracts
Searches for heavy ZZ and ZW resonances in the llqq and vvqq final states in pp collisions at √ s=13 TeV with the ATLAS detector

This paper reports searches for heavy resonances decaying into ZZ or ZW using data from proton-proton collisions at a centre-of-mass energy of s√=13 TeV. The data, corresponding to an integrated luminosity of 36.1 fb−1, were recorded with the ATLAS detector in 2015 and 2016 at the Large Hadron Collider. The searches are performed in final states in which one Z boson decays into either a pair of light charged leptons (electrons and muons) or a pair of neutrinos, and the associated W boson or the other Z boson decays hadronically. No evidence of the production of heavy resonances is observed. Upper bounds on the production cross sections of heavy resonances times their decay branching ratios to ZZ or ZW are derived in the mass range 300-5000GeV within the context of Standard Model extensions with additional Higgs bosons, a heavy vector triplet or warped extra dimensions. Production through gluon-gluon fusion, Drell-Yan or vector-boson fusion are considered, depending on the assumed mode