pinecone/core-2020-05-10-deduplication huggingface dataset:
First look at the physics case of TLEP.

The discovery by the ATLAS and CMS experiments of a new boson with mass around 125 GeV and with measured properties compatible with those of a Standard-Model Higgs boson, coupled with the absence of discoveries of phenomena beyond the Standard Model at the TeV scale, has triggered interest in ideas for future Higgs factories. A new circular e+e− collider hosted in a 80 to 100 km tunnel, TLEP, is among the most attractive solutions proposed so far. It has a clean experimental environment, produces high luminosity for top-quark, Higgs boson, W and Z studies, accommodates multiple detectors, and can reach energies up to the tt¯ threshold and beyond. It will enable measurements of the Higgs boson properties and of Electroweak Symmetry-Breaking (EWSB) parameters with unequalled precision, offering exploration of physics beyond the Standard Model in the multi-TeV range. Moreover, being the natural precursor of the VHE-LHC, a 100 TeV hadron machine in the same tunnel, it builds up a long-term vision for particle physics. Altogether, the combination of TLEP and the VHE-LHC offers, for a great cost effectiveness, the best precision and the best search reach of all options presently on the market. This paper presents a first appraisal of the salient features of the TLEP physics potential, to serve as a baseline for a more extensive design study
Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium.

Background: Delirium is a profound neuropsychiatric disturbance precipitated by acute illness. Although dementia is the major risk factor this has typically been considered a binary quantity (i.e., cognitively impaired versus cognitively normal) with respect to delirium risk. We used humans and mice to address the hypothesis that the severity of underlying neurodegenerative changes and/or cognitive impairment progressively alters delirium risk.\ud
Methods: Humans in a population-based longitudinal study, Vantaa 85+, were followed for incident delirium. Odds for reporting delirium at follow-up (outcome) were modeled using random-effects logistic regression, where prior cognitive impairment measured by Mini-Mental State Exam (MMSE) (exposure) was considered. To address whether underlying neurodegenerative pathology increased susceptibility to acute cognitive change, mice at three stages of neurodegenerative disease progression (ME7 model of neurodegeneration: controls, 12 weeks, and 16 weeks) were assessed for acute cognitive dysfunction upon systemic inflammation induced by bacterial lipopolysaccharide (LPS; 100 μg/kg). Synaptic and axonal correlates of susceptibility to acute dysfunction were assessed using immunohistochemistry.\ud
Results: In the Vantaa cohort, 465 persons (88.4 ± 2.8 years) completed MMSE at baseline. For every MMSE point lost, risk of incident delirium increased by 5% (p = 0.02). LPS precipitated severe and fluctuating cognitive deficits in 16-week ME7 mice but lower incidence or no deficits in 12-week ME7 and controls, respectively. This was associated with progressive thalamic synaptic loss and axonal pathology.\ud
Conclusions: A human population-based cohort with graded severity of existing cognitive impairment and a mouse model with progressing neurodegeneration both indicate that the risk of delirium increases with greater severity of pre-existing cognitive impairment and neuropathology
A novel model of urinary tract differentiation, tissue regeneration, and disease : reprogramming human prostate and bladder cells into induced pluripotent stem cells.

Background: Primary culture and animal and cell-line models of prostate and bladder development have limitations in describing human biology, and novel strategies that describe the full spectrum of differentiation from foetal through to ageing tissue are required. Recent advances in biology demonstrate that direct reprogramming of somatic cells into pluripotent embryonic stem cell (ESC)-like cells is possible. These cells, termed induced pluripotent stem cells (iPSCs), could theoretically generate adult prostate and bladder tissue, providing an alternative strategy to study differentiation.\ud
Objective: To generate human iPSCs derived from normal, ageing, human prostate (Pro-iPSC), and urinary tract (UT-iPSC) tissue and to assess their capacity for lineage-directed differentiation.\ud
Design, setting, and participants: Prostate and urinary tract stroma were transduced with POU class 5 homeobox 1 (POU5F1; formerly OCT4), SRY (sex determining region Y)-box 2 (SOX2), Kruppel-like factor 4 (gut) (KLF4), and v-myc myelocytomatosis viral oncogene homolog (avian) (MYC, formerly C-MYC) genes to generate iPSCs.\ud
Outcome measurements and statistical analysis: The potential for differentiation into prostate and bladder lineages was compared with classical skin-derived iPSCs. The student t test was used.\ud
Results and limitations: Successful reprogramming of prostate tissue into Pro-iPSCs and bladder and ureter into UT-iPSCs was demonstrated by characteristic ESC morphology, marker expression, and functional pluripotency in generating all three germ-layer lineages. In contrast to conventional skin-derived iPSCs, Pro-iPSCs showed a vastly increased ability to generate prostate epithelial-specific differentiation, as characterised by androgen receptor and prostate-specific antigen induction. Similarly, UT-iPSCs were shown to be more efficient than skin-derived iPSCs in undergoing bladder differentiation as demonstrated by expression of urothelial-specific markers: uroplakins, claudins, and cytokeratin; and stromal smooth muscle markers: α-smooth-muscle actin, calponin, and desmin. These disparities are likely to represent epigenetic differences between individual iPSC lines and highlight the importance of organ-specific iPSCs for tissue-specific studies.\ud
Conclusions: IPSCs provide an exciting new model to characterise mechanisms regulating prostate and bladder differentiation and to develop novel approaches to disease modelling. Regeneration of bladder cells also provides an exceptional opportunity for translational tissue engineering
Lifshitz flows in IIB and dual field theories.\ud

We construct solutions describing flows between AdS and Lifshitz spacetimes in IIB supergravity. We find that flows from AdS5 can approach either AdS3 or Lifshitz3 in the IR depending on the values of the deformation from AdS5. Surprisingly, the choice between AdS and Lifshitz IR depends only on the value of the deformation, not on its character; the breaking of the Lorentz symmetry in the flows with Lifshitz IR is spontaneous. We find that the values of the deformation which lead to flows to Lifshitz make the UV field theory dual to the AdS5 geometry unstable, so that these flows do not offer an approach to defining the field theory dual to the Lifshitz spacetime
The effect of auditory verbal imagery on signal detection in hallucination-prone individuals.

Cognitive models have suggested that auditory hallucinations occur when internal mental events, such as inner speech or auditory verbal imagery (AVI), are misattributed to an external source. This has been supported by numerous studies indicating that individuals who experience hallucinations tend to perform in a biased manner on tasks that require them to distinguish self-generated from non-self-generated perceptions. However, these tasks have typically been of limited relevance to inner speech models of hallucinations, because they have not manipulated the AVI that participants used during the task. Here, a new paradigm was employed to investigate the interaction between imagery and perception, in which a healthy, non-clinical sample of participants were instructed to use AVI whilst completing an auditory signal detection task. It was hypothesized that AVI-usage would cause participants to perform in a biased manner, therefore falsely detecting more voices in bursts of noise. In Experiment 1, when cued to generate AVI, highly hallucination-prone participants showed a lower response bias than when performing a standard signal detection task, being more willing to report the presence of a voice in the noise. Participants not prone to hallucinations performed no differently between the two conditions. In Experiment 2, participants were not specifically instructed to use AVI, but retrospectively reported how often they engaged in AVI during the task. Highly hallucination-prone participants who retrospectively reported using imagery showed a lower response bias than did participants with lower proneness who also reported using AVI. Results are discussed in relation to prominent inner speech models of hallucinations
The effects of junction interdiffusion and misfit dislocations on the efficiency of highly mismatched heterojunction photovoltaic devices.

A general modelling methodology has been developed to evaluate the effects of chemical interdiffusion and misfit dislocations on the performance of heterojunction solar cells made from highly mismatched materials. Results for the exemplar materials system CdS-CdTe are contrary to the widely held belief that such interdiffusion is beneficial to photovoltaic performance. In the model, recombination is presumed to take place at the cores of misfit dislocations, with the distribution of these dislocations in the interdiffused layer being calculated so as to minimise the total energy (an incidental result shows that the total number of dislocations is independent of the diffusion profile). The model takes calculated chemical profiles, optical absorption, and dislocation distributions from which the photovoltaic performance and recombination losses are evaluated. It was shown that for the realistic case in which the interdiffused region does not extend beyond the space charge region, the photovoltage losses dominate over any photocurrent gains. Methods to engineer mixed junctions that may increase solar conversion efficiency are discussed
Sound::Gender::Feminism::Activism: Research and Challenges to the Orthodoxies of Sound Arts

The previously anecdotal lack of a broad engagement by women in sound art and music technology in the UK has been confirmed by the statistical evidence and analysis undertaken by the MusDig project. Initiatives designed to widen participation through access to production resources, both inside and outside formal education, have proved to be qualitatively important but quantitatively ineffective with the figures for women’s participation hovering stubbornly around the same percentages. In order for the situation to improve, I argue that there needs to be a seismic cultural shift in the critical and contextual frameworks that surround sound art, contemporary music and music technology, one that will challenge existing orthodoxies and enable a wider range of diversity and of practices to be encompassed within the sounding arts
Resolution of a conflict between Laser and Elementary Particle Physics

The claim some years ago, contrary to all textbooks, that the angular
momentum of a photon (and gluon) can be split in a gauge-invariant way into an
orbital and spin term, sparked a major controversy in the Particle Physics
community. A further cause of upset was the realization that the gluon
polarization in a nucleon, a supposedly physically meaningful quantity,
corresponds only to the gauge-variant gluon spin derived from Noether's
theorem, evaluated in a particular gauge. On the contrary, Laser Physicists
have, for decades, been happily measuring physical quantities which correspond
to orbital and spin angular momentum evaluated in a particular gauge. This
paper reconciles the two points of view.Comment: 6 pages, no figure
Neutrino phenomenology and scalar Dark Matter with $A_{4}$ flavor
  symmetry in Inverse and type II seesaw

We present a TeV scale seesaw mechanism for exploring the dark matter and
neutrino phenomenology in the light of recent neutrino and cosmology data. A
different realization of the Inverse seesaw(ISS) mechanism with $A_{4}$ flavor
symmetry is being implemented as a leading contribution to the light neutrino
mass matrix which usually gives rise to vanishing reactor mixing angle
$\theta_{13}$. Using a non-diagonal form of Dirac neutrino mass matrix and
$3\sigma$ values of mass square differences we parameterize the neutrino mass
matrix in terms of Dirac Yukawa coupling "$y$". We then use type II seesaw as a
perturbation which turns out to be active to have a non-vanishing reactor
mixing angle without much disturbing the other neutrino oscillation parameters.
Then we constrain a common parameter space satisfying the non-zero
$\theta_{13}$, Yukawa coupling and the relic abundance of dark matter.
Contributions of neutrinoless double beta decay are also included for standard
as well as non-standard interaction. This study may have relevance in future
neutrino and Dark Matter experiments.Comment: 29 pages, 13 figures (Model has been changed, Contributions of
  neutrinoless double beta decay are included, more references added), to
  appear in Nucl. Phys.
Roaming form factors for the tricritical to critical Ising flow

We study the massless flows described by the staircase model introduced by
Al.B. Zamolodchikov through the analytic continuation of the sinh-Gordon
S-matrix, focusing on the renormalisation group flow from the tricritical to
the critical Ising model. We show that the properly defined roaming limits of
certain sinh-Gordon form factors are identical to the form factors of the order
and disorder operators for the massless flow. As a by-product, we also
construct form factors for a semi-local field in the sinh-Gordon model, which
can be associated with the twist field in the ultraviolet limiting free
massless bosonic theory.Comment: 23 pages, Latex2e file. v2: published version, clarifications added,
  typos correcte
Estimating a Preference-Based Index for an Eight-Dimensional Health State Classification System for Multiple Sclerosis.

PublishedJournal ArticleBACKGROUND: Condition-specific measures are frequently used to assess the health-related quality of life of people with multiple sclerosis (MS). Such measures are unsuitable for use in economic evaluations that require estimates of cost per quality-adjusted life-year because they are not based on preferences. OBJECTIVES: To report the estimation of a preference-based single index for an eight-dimensional instrument for MS, the Multiple Sclerosis Impact Scale - Eight Dimensions (MSIS-8D), derived from an MS-specific measure of health-related quality of life, the 29-item Multiple Sclerosis Impact Scale (MSIS-29). METHODS: We elicited preferences for a sample of MSIS-8D states (n = 169) from a sample (n = 1702) of the UK general population. Preferences were elicited using the time trade-off technique via an Internet-based survey. We fitted regression models to these data to estimate values for all health states described by the MSIS-8D. Estimated values were assessed against MSIS-29 scores and values derived from generic preference-based measures in a large, representative sample of people with MS. RESULTS: Participants reported that the time trade-off questions were easy to understand. Observed health state values ranged from 0.08 to 0.89. The best-performing model was a main effects, random effects model (mean absolute error = 0.04). Validation analyses support the performance of the MSIS-8D index: it correlated more strongly than did generic measures with MSIS-29 scores, and it discriminated effectively between subgroups of people with MS. CONCLUSIONS: The MSIS-8D enables health state values to be estimated from the MSIS-29, adding to the methods available to assess health outcomes and to estimate quality-adjusted life-years for MS for use in health technology assessment and decision-making contexts
Regular and irregular patterns of self-localized excitation in arrays of coupled phase oscillators.

This is the author manuscript. The final version is available from the publisher via the DOI in this record.We study a system of phase oscillators with nonlocal coupling in a ring that supports self-organized patterns of coherence and incoherence, called chimera states. Introducing a global feedback loop, connecting the phase lag to the order parameter, we can observe chimera states also for systems with a small number of oscillators. Numerical simulations show a huge variety of regular and irregular patterns composed of localized phase slipping events of single oscillators. Using methods of classical finite dimensional chaos and bifurcation theory, we can identify the emergence of chaotic chimera states as a result of transitions to chaos via period doubling cascades, torus breakup, and intermittency. We can explain the observed phenomena by a mechanism of self-modulated excitability in a discrete excitable medium.We want to thank Y. L. Maistrenko for pointing out to us the importance of small size chimera states. M.W.
acknowledges the support by DFG within the collaborative research center SFB 910
Development and psychometric evaluation of a new measure for children\u27s participation in hand-use life situations

Objective To describe the development of the Children\u27s Assessment of Participation with Hands, a parent-report questionnaire that assesses children\u27s participation in life situations requiring hand use specifically, and to investigate its construct validity (using Rasch analysis and known-group comparison) and reliability (test-retest reliability and internal consistency). Design Cross-sectional, validation, and test-retest studies. Setting Schools. Participants Parents/caregivers (N=202) reported on their children aged 2 to 12 years with (n=97) and without disabilities (n=105). Interventions Not applicable. Main Outcome Measure The Children\u27s Assessment of Participation with Hands was developed based on a content review of existing children\u27s participation measures and literature, expert review, and pilot testing. The Children\u27s Assessment of Participation with Hands included 37 items measuring participation diversity, frequency, independence, and desire for change in specific hand-use life situations across 4 domains of self-care, recreation, education, and domestic life and community. Results Evidence for construct validity of the Children\u27s Assessment of Participation with Hands domains was established through Rasch analysis (after removing 2 misfitting items from the recreational domain and 1 item from the domestic life and community domain). Differences in summary scores of each domain between children with and without disabilities were also significant (
Multiwavelength study of the fast rotating supergiant high-mass X-ray binary IGR J16465−4507

Context. Since its launch, the X-ray and γ-ray observatory INTEGRAL satellite has revealed a new class of high-mass X-ray binaries (HMXB) displaying fast flares and hosting supergiant companion stars. Optical and infrared (OIR) observations in a multi-wavelength context are essential to understand the nature and evolution of these newly discovered celestial objects. Aims. The goal of this multiwavelength study (from ultraviolet to infrared) is to characterise the properties of IGR J16465−4507, to confirm its HMXB nature and that it hosts a supergiant star. Methods. We analysed all OIR, photometric and spectroscopic observations taken on this source, carried out at ESO facilities. Results. Using spectroscopic data, we constrained the spectral type of the companion star between B0.5 and B1 Ib, settling the debate on the true nature of this source. We measured a high rotation velocity of v = 320 ± 8km s-1 from fitting absorption and emission lines in a stellar spectral model. We then built a spectral energy distribution from photometric observations to evaluate the origin of the different components radiating at each energy range. Conclusions. We finally show that, having accurately determined the spectral type of the early-B supergiant in IGR J16465−4507, we firmly support its classification as an intermediate supergiant fast X-ray transient (SFXT).This work was supported by the Centre National d’Études Spatiales (CNES). It is based on observations obtained with MINE: the Multi-wavelength INTEGRAL NEtwork. This research is partially supported by the Spanish Mineco under grants AYA2012-39364-C02-01/02. The work of IND is also supported by the Spanish Ministerio de Educación y Ciencia under grant PRX14-00169
Generation of scaffoldless hyaline cartilaginous tissue from human iPSCs.

Defects in articular cartilage ultimately result in loss of joint function. Repairing cartilage defects requires cell sources. We developed an approach to generate scaffoldless hyaline cartilage from human induced pluripotent stem cells (hiPSCs). We initially generated an hiPSC line that specifically expressed GFP in cartilage when teratoma was formed. We optimized the culture conditions and found BMP2, transforming growth factor β1 (TGF-β1), and GDF5 critical for GFP expression and thus chondrogenic differentiation of the hiPSCs. The subsequent use of scaffoldless suspension culture contributed to purification, producing homogenous cartilaginous particles. Subcutaneous transplantation of the hiPSC-derived particles generated hyaline cartilage that expressed type II collagen, but not type I collagen, in immunodeficiency mice. Transplantation of the particles into joint surface defects in immunodeficiency rats and immunosuppressed mini-pigs indicated that neocartilage survived and had potential for integration into native cartilage. The immunodeficiency mice and rats suffered from neither tumors nor ectopic tissue formation. The hiPSC-derived cartilaginous particles constitute a viable cell source for regenerating cartilage defects
Approximating the limit: the interaction between quasi 'almost' and some temporal connectives in Italian

This paper focuses on the interpretation of the Italian approximative adverb quasi 'almost' by primarily looking at cases in which it modifies temporal connectives, a domain which, to our knowledge, has been largely unexplored thus far. Consideration of this domain supports the need for a scalar account of the semantics of quasi (close in spirit to Hitzeman's 1992 semantic analysis of almost). When paired with suitable analyses of temporal connectives, such an account can provide a simple explanation of the patterns of implication that are observed when quasi modifies locational (e.g. quando 'when'), directional (e.g. fino 'until' and da 'since'), and event-sequencing temporal connectives (e.g. prima 'before' and dopo 'after'). A challenging empirical phenomenon that is observed is a contrast between the modification of fino and da by quasi, on the one hand, and the modification of prima and dopo by the same adverb, on the other. While quasi fino and quasi da behave symmetrically, a puzzling asymmetry is observed between quasi prima and quasi dopo. To explain the asymmetry, we propose an analysis of prima and dopo on which the former has the meaning of the temporal comparative più presto 'earlier', while the latter is seen as an atomic predicate denoting temporal succession between events (Del Prete 2008). We show that the same pattern of implication observed for quasi prima is attested when quasi modifies overt comparatives, and propose a pragmatic analysis of this pattern that uniformly applies to both cases, thus providing new evidence for the claim that prima is underlyingly a comparative. A major point of this paper is a discussion of the notion of scale which is relevant for the semantics of quasi; in particular, we show that the notion of Horn (entailment-based) scale is not well-suited for handling modification of temporal connectives, and that a more general notion of scale is required in order to provide a uniform analysis of quasi as a cross-categorial modifier