pinecone/core-2020-05-10-deduplication huggingface dataset:
Improvement in bladder storage function by tamsulosin depends on suppression of C-fiber urethral afferent activity in rats.

PURPOSE: Alpha(1)-blockers improve voiding symptoms by decreasing prostatic and urethral smooth muscle tone. However, to our knowledge the mechanism underlying improvements in storage symptoms is not known. Topical application of prostaglandin E(2) to the rat lower urinary tract stimulates the micturition reflex. Using an animal model we investigated whether the alpha(1)-blocker tamsulosin (Astellas Pharma, Tokyo, Japan) acts on C-fiber afferent activity and, if so, the location of this effect. MATERIALS AND METHODS: To induce desensitization of C-fiber afferent activity resiniferatoxin (0.3 mg/kg) was subcutaneously injected in female Sprague-Dawley rats 2 days before experiments. Simultaneous recordings of urethral pressure and rhythmic bladder pressure were made with the rats under urethane anesthesia. Prostaglandin E(2) (0.4 mg/ml) was continuously administered intravesically or intraurethrally to rats pretreated with resiniferatoxin (resiniferatoxin rats) or rats without pretreatment (nonresiniferatoxin rats). We investigated the effects on the micturition reflex of intravenous (2.2 x 10(-1) to 2.2 x 10(3) nM/kg) or intrathecal (0.001 to 0.1 nmol) administration of tamsulosin. RESULTS: The bladder contraction interval was markedly decreased after intravesical or intraurethral administration of prostaglandin E(2) in nonresiniferatoxin rats but it was unchanged in resiniferatoxin rats. This effect was antagonized by the EP1 receptor antagonist ONO-8711 (6-[(2S,3S)-3-(4-chloro-2-methylphenylsulfonylaminomethyl)-bicyclo[2.2.2]octan-2-yl]-5Z-hexenoic acid). Intravenous administration of tamsulosin significantly increased the bladder contraction interval in nonresiniferatoxin rats receiving intraurethral prostaglandin E(2) but it had no effect on nonresiniferatoxin rats receiving intravesical prostaglandin E(2). Intrathecal administration of tamsulosin produced a slight and insignificant increase in the bladder contraction interval in nonresiniferatoxin rats receiving intraurethral prostaglandin E(2). CONCLUSIONS: These results suggest that prostaglandin E(2) enhances the micturition reflex through C-fiber afferents and tamsulosin had an inhibitory effect on the C-fiber urethral afferent nerves, thereby improving bladder storage function
White organic light-emitting devices with a solution-processed and molecular host-employed emission layer

[[abstract]]The brightness, efficiency, chromaticity, and processibility of white organic light-emitting devices have been markedly improved by forming therein via spin-coating a single white emission layer, in which the red, green, and blue dyes of iridium-based complexes were previously solution-mixed into the host matrix composed of small molecules instead of polymers. Among the hosts studied, the 4,4-bis(carbazol-9-yl)-biphenyl-based devices performed best in terms of luminance and efficiency for having the lowest-energy barrier for electrons to inject from the hole-blocking layer to the host layer. The device having a pure white emission of (0.34, 0.35) had a maximum power efficiency of 2.9  lm/W at an applicable luminance of 1680  cd/m2, while 5.6  lm/W at 550  cd/m2 for that of (0.34, 0.39).[[fileno]]2020306010001[[department]]材料科學工程學
Formation of collisionless shocks in magnetized plasma interaction with
  kinetic-scale obstacles

We investigate the formation of collisionless magnetized shocks triggered by
the interaction between magnetized plasma flows and miniature-sized (order of
plasma kinetic-scales) magnetic obstacles resorting to massively parallel, full
particle-in-cell simulations, including the electron kinetics. The critical
obstacle size to generate a compressed plasma region ahead of these objects is
determined by independently varying the magnitude of the dipolar magnetic
moment and the plasma magnetization. We find that the effective size of the
obstacle depends on the relative orientation between the dipolar and plasma
internal magnetic fields, and we show that this may be critical to form a shock
in small-scale structures. We study the microphysics of the magnetopause in
different magnetic field configurations in 2D and compare the results with full
3D simulations. Finally, we evaluate the parameter range where such miniature
magnetized shocks can be explored in laboratory experiments
A Salmonella toxin promotes persister formation through acetylation of tRNA

The recalcitrance of many bacterial infections to antibiotic treatment is thought to be due to the presence of persisters that are non-growing, antibiotic-insensitive cells. Eventually, persisters resume growth, accounting for relapses of infection. Salmonella is an important pathogen that causes disease through its ability to survive inside macrophages. After macrophage phagocytosis, a significant proportion of the Salmonella population forms non-growing persisters through the action of toxin-antitoxin modules. Here we reveal that one such toxin, TacT, is an acetyltransferase that blocks the primary amine group of amino acids on charged tRNA molecules, thereby inhibiting translation and promoting persister formation. Furthermore, we report the crystal structure of TacT and note unique structural features, including two positively charged surface patches that are essential for toxicity. Finally, we identify a detoxifying mechanism in Salmonella wherein peptidyl-tRNA hydrolase counteracts TacT-dependent growth arrest, explaining how bacterial persisters can resume growth
A Restricted Repertoire of De Novo Mutations in ITPR1 Cause Gillespie Syndrome with Evidence for Dominant-Negative Effect

Gillespie syndrome (GS) is characterized by bilateral iris hypoplasia, congenital hypotonia, non-progressive ataxia, and progressive cerebellar atrophy. Trio-based exome sequencing identified de novo mutations in ITPR1 in three unrelated individuals with GS recruited to the Deciphering Developmental Disorders study. Whole-exome or targeted sequence analysis identified plausible disease-causing ITPR1 mutations in 10/10 additional GS-affected individuals. These ultra-rare protein-altering variants affected only three residues in ITPR1: Glu2094 missense (one de novo, one co-segregating), Gly2539 missense (five de novo, one inheritance uncertain), and Lys2596 in-frame deletion (four de novo). No clinical or radiological differences were evident between individuals with different mutations. ITPR1 encodes an inositol 1,4,5-triphosphate-responsive calcium channel. The homo-tetrameric structure has been solved by cryoelectron microscopy. Using estimations of the degree of structural change induced by known recessive- and dominant-negative mutations in other disease-associated multimeric channels, we developed a generalizable computational approach to indicate the likely mutational mechanism. This analysis supports a dominant-negative mechanism for GS variants in ITPR1. In GS-derived lymphoblastoid cell lines (LCLs), the proportion of ITPR1-positive cells using immunofluorescence was significantly higher in mutant than control LCLs, consistent with an abnormality of nuclear calcium signaling feedback control. Super-resolution imaging supports the existence of an ITPR1-lined nucleoplasmic reticulum. Mice with Itpr1 heterozygous null mutations showed no major iris defects. Purkinje cells of the cerebellum appear to be the most sensitive to impaired ITPR1 function in humans. Iris hypoplasia is likely to result from either complete loss of ITPR1 activity or structure-specific disruption of multimeric interactions
Automated protocol selection for energy efficient wSN applications

A mature wireless sensor network automation tool requires the implementation of different protocols for different topology and application scenarios to optimise the overall system performance. Focusing on the transport layer energy-aware routing function for the Tyndall Heterogeneous Automated Wireless Sensor (THAWS), embedding a reactive routing protocol, an energy-efficient proactive heuristic protocol and a distributed geographical routing mechanism on the Tyndall 10 and 25 mm nodes is proposed. Those protocols manage small, medium and large sensor applications adaptively, while the end users of the THAWS tool are transparent from protocol selection
Risk of lung cancer mortality in nuclear workers from internal
                exposure to alpha particle-emitting radionuclides

BACKGROUND:

Carcinogenic risks of internal exposures to alpha-emitters (except radon) are poorly understood. Since exposure to alpha particles-particularly through inhalation-occurs in a range of settings, understanding consequent risks is a public health priority. We aimed to quantify dose-response relationships between lung dose from alpha-emitters and lung cancer in nuclear workers.
METHODS:

We conducted a case-control study, nested within Belgian, French, and UK cohorts of uranium and plutonium workers. Cases were workers who died from lung cancer; one to three controls were matched to each. Lung doses from alpha-emitters were assessed using bioassay data. We estimated excess odds ratio (OR) of lung cancer per gray (Gy) of lung dose.
RESULTS:

The study comprised 553 cases and 1,333 controls. Median positive total alpha lung dose was 2.42 mGy (mean: 8.13 mGy; maximum: 316 mGy); for plutonium the median was 1.27 mGy and for uranium 2.17 mGy. Excess OR/Gy (90% confidence interval)-adjusted for external radiation, socioeconomic status, and smoking-was 11 (2.6, 24) for total alpha dose, 50 (17, 106) for plutonium, and 5.3 (-1.9, 18) for uranium.
CONCLUSIONS:

We found strong evidence for associations between low doses from alpha-emitters and lung cancer risk. The excess OR/Gy was greater for plutonium than uranium, though confidence intervals overlap. Risk estimates were similar to those estimated previously in plutonium workers, and in uranium miners exposed to radon and its progeny. Expressed as risk/equivalent dose in sieverts (Sv), our estimates are somewhat larger than but consistent with those for atomic bomb survivors.See video abstract at, http://links.lww.com/EDE/B232
On-line identification of seeds in mandarins with magnetic resonance imaging

Mandarins have been inspected using magnetic resonance imaging (MRI) in order to detect the presence of seeds. To enhance contrast between seeds and pulp, effective transverse relaxation time-weighted fast low angle shot images (703 ms acquisition time) were acquired. Stationary fruits were imaged and then the images were segmented to extract several features. The maximum radius of the region containing the seeds and the central axis rmax, and the perimeter of this region P were the most powerful features for discrimination between seedless and seed-containing fruits. Such features were the most robust since they showed the lowest noise-to-signal ratios (N/S). The proportions of correct classification were 88.9% and 86.7% for seedless and seed-containing fruits, respectively, under MRI stationary conditions. The performance under on-line conditions was evaluated by imaging the fruits while conveyed at 54 mm/s. An analysis of variance with the features extracted from the static images and the motion-corrected dynamic images showed that there were statistically indistinguishable. The proportions of correct classification were 92.5% and 79.5% for the seedless and seed-containing category, respectively, under MRI dynamic conditions. Reduction in the distance between categories for rmax was addressed as the main cause for the decrease in discrimination performance. The robustness of the motion correction procedure was highlighted by the low differences in the N/S ratio and the noise-to-measured range ratios between static and dynamic features
Larger crises cost more: impact of banking sector instability on output growth

We propose a method for calculating the macroeconomic costs of banking crises that controls for the downward impact of recessions on banking activity. In contrast to earlier research, we estimate the cost of crises based on the size of banking crises. The extent of a crisis is measured using banking sector aggregates. The results, based on our method and data from over 100 banking crises, suggest that the size of a crisis matters for economic growth. Lower credit, deposit and money growth during crises cause GDP growth to decline.
The source of the 1722 Algarve earthquake: evidence from MCS and Tsunami data

Abstract  The 27 December 1722 Algarve earthquake destroyed a large area in southern Portugal generating a local tsunami that inundated the shallow areas of Tavira. It is unclear whether its source was located onshore or offshore and, in any case, what was the tectonic source responsible for the event. We analyze available historical information concerning macroseismicity and the tsunami to discuss the most probable location of the source. We also review available seismotectonic knowledge of the offshore region close to the probable epicenter, selecting a set of four candidate sources. We simulate tsunamis produced by these candidate sources assuming that the sea bottom displacement is caused by a compressive dislocation over a rectangular fault, as given by the half-space homogeneous elastic approach, and we use numerical modeling to study wave propagation and run-up. We conclude that the 27 December 1722 Tavira earthquake and tsunami was probably generated offshore, close to 37?01'N, 7?49'W.http://dx.doi.org/10.1007/s10950-007-9058-
Synchronous parallel kinetic Monte Carlo for\ud
continuum diffusion-reaction systems

A novel parallel kinetic Monte Carlo (kMC) algorithm formulated on the basis of perfect time synchronicity is presented. The algorithm is intended as a generalization of the standard n-fold kMC method, and is trivially implemented in parallel architectures. In its present form, the algorithm is not rigorous in the sense that boundary conflicts are ignored. We demonstrate, however, that, in their absence, or if they were correctly accounted for, our algorithm solves the same master equation as the serial method. We test the validity and parallel performance of the method by solving several pure diffusion problems (i.e. with no particle interactions) with known analytical solution. We also study diffusion-reaction systems with known asymptotic behavior and find that, for large systems with interaction radii smaller than the typical diffusion length, boundary conflicts are negligible and do not affect the global kinetic evolution, which is seen to agree with the expected analytical behavior. Our method is a controlled approximation in the sense that the error incurred by ignoring boundary conflicts can be quantified intrinsically, during the course of a simulation, and decreased arbitrarily (controlled) by modifying a few problem-dependent simulation parameters
Disparate connectivity for structural and functional networks is revealed when physical location of the connected nodes is considered

Macroscopic brain networks have been widely described with the manifold of metrics available using graph theory. However, most analyses do not incorporate information about the physical position of network nodes. Here, we provide a multimodal macroscopic network characterization while considering the physical positions of nodes. To do so, we examined anatomical and functional macroscopic brain networks in a sample of twenty healthy subjects. Anatomical networks are obtained with a graph based tractography algorithm from diffusion-weighted magnetic resonance images (DW-MRI). Anatomical con- nections identified via DW-MRI provided probabilistic constraints for determining the connectedness of 90 dif- ferent brain areas. Functional networks are derived from temporal linear correlations between blood-oxygenation level-dependent signals derived from the same brain areas. Rentian Scaling analysis, a technique adapted from very- large-scale integration circuits analyses, shows that func- tional networks are more random and less optimized than the anatomical networks. We also provide a new metric that allows quantifying the global connectivity arrange- ments for both structural and functional networks. While the functional networks show a higher contribution of inter-hemispheric connections, the anatomical networks highest connections are identified in a dorsal?ventral arrangement. These results indicate that anatomical and functional networks present different connectivity organi- zations that can only be identified when the physical locations of the nodes are included in the analysis
Renal biopsy findings among Indigenous Australians: a nationwide review

Australia\u27s Indigenous people have high rates of chronic kidney disease and kidney failure. To define renal disease among these people, we reviewed 643 renal biopsies on Indigenous people across Australia, and compared them with 249 biopsies of non-Indigenous patients. The intent was to reach a consensus on pathological findings and terminology, quantify glomerular size, and establish and compare regional biopsy profiles. The relative population-adjusted biopsy frequencies were 16.9, 6.6, and 1, respectively, for Aboriginal people living remotely/very remotely, for Torres Strait Islander people, and for non-remote-living Aboriginal people. Indigenous people more often had heavy proteinuria and renal failure at biopsy. No single condition defined the Indigenous biopsies and, where biopsy rates were high, all common conditions were in absolute excess. Indigenous people were more often diabetic than non-Indigenous people, but diabetic changes were still present in fewer than half their biopsies. Their biopsies also had higher rates of segmental sclerosis, post-infectious glomerulonephritis, and mixed morphologies. Among the great excess of biopsies in remote/very remote Aborigines, females predominated, with younger age at biopsy and larger mean glomerular volumes. Glomerulomegaly characterized biopsies with mesangiopathic changes only, with IgA deposition, or with diabetic change, and with focal segmental glomerulosclerosis (FSGS). This review reveals great variations in biopsy rates and findings among Indigenous Australians, and findings refute the prevailing dogma that most indigenous renal disease is due to diabetes. Glomerulomegaly in remote/very remote Aboriginal people is probably due to nephron deficiency, in part related to low birth weight, and probably contributes to the increased susceptibility to kidney disease and the predisposition to FSGS
That sounds sweet: using cross-modal correspondences to communicate gustatory attributes

This is the authors' accepted and refereed manuscript to the articleBuilding on existing research into sound symbolism and crossmodal correspondences, this article proposes that crossmodal correspondences—systematic mappings between different sensory modalities—can be used to communicate non-musical, low-level sensory properties such as basic tastes through music. A series of three experiments demonstrates that crossmodal correspondences enable people to systematically encode basic taste properties into parameters in musical space (Experiment 1), and that they are able to correctly decode basic taste information embedded in complex musical compositions (Experiments 2 and 3). The results also suggest some culture-specificity to these mappings, given that decoding performance, while still above chance levels, was lower in Indian participants than in those from the United States (Experiment 3). Implications and potential applications of these findings are discussed.1, Forfatterversjo
Effects of restoration management on the estuarine isopod Cyathura carinata: mediation by trematodes and habitat change

Abstract  A restoration programme was introduced in the Mondego Estuary (Portugal) to recover seagrass beds of Zostera noltii endangered by eutrophication. A long-term survey of 10 years was used to assess the development of the processes involved, focusing one of the key species (Cyathura carinata, Isopoda). The mitigation measures implemented since 1998 (nutrient loading reduction, freshwater circulation improvement and seagrass bed protection) enhanced water quality and seagrass recovery, thus preventing the development of macroalgal blooms. C. carinata was resilient to the occurrence of floods and macroalgal blooms, although both events caused dispersion of individuals. This isopod was not much influenced by the changes occurring in the estuary, showing an unalterable population structure during the entire study period. After 1998, its density and biomass became more stable at an inner unvegetated sand flat area, where this isopod was most abundant; its population slightly increased in a bare mud flat at the middle section of the estuary; but it could not establish successfully in a downstream Z. noltii bed, contrarily to other common estuarine species. Apart from other unknown reasons, the disrupted balanced between trematodes and their hosts, caused by the eutrophication processes, may have an important role in the discontinuity of C. carinata at the Z. noltii bed. If the intertidal areas become fully restored to the original seagrass coverage, high prevalence and intensity trematodes may prevent this isopod and other crustaceans from recovering within the intervened areas, by enhancing host mortality and recruitment failure. In order to avoid this kind of situation, it may be necessary to survey the levels of parasite infestation within the target hosts and safeguard areas where crustaceans present healthy populations.http://dx.doi.org/10.1007/s00227-006-0455-
Experimental Evidence of Fluctuation-Dissipation Theorem Violation in a
  Superspin Glass

We present the experimental observation of the fluctuation-dissipation
theorem (FDT) violation in an assembly of interacting magnetic nanoparticles in
the low temperature superspin glass phase. The magnetic noise is measured with
a two-dimension electron gas Hall probe and compared to the out of phase ac
susceptibility of the same ferrofluid. For "intermediate" aging times of the
order of 1 h, the ratio of the effective temperature $T_{\rm eff}$ to the bath
temperature T grows from 1 to 6.5 when T is lowered from $T_g$ to 0.3 $T_g$,
regardless of the noise frequency. These values are comparable to those
measured in an atomic spin glass as well as those calculated for a Heisenberg
spin glass
Time-reversal odd distribution functions in chiral models with vector
  mesons

The so-called time-reversal odd distribution functions are known to be
non-vanishing in QCD due to the presence of the link operator in the definition
of these quantities. I show that T-odd distributions can be non-vanishing also
in chiral models, if vector mesons are introduced as dynamical gauge bosons of
a hidden local symmetry. Moreover, since the flavor dependence of these
distributions is different in chiral models respect to non chiral ones, the
phenomenological analysis of experimental data will be able to distinguish
between these two classes of models.Comment: 4 page
Dynamics of bulk fluctuations in a lamellar phase studied by coherent
  x-ray scattering

Using x-ray photon correlation spectroscopy, we studied the layer
fluctuations in the lamellar phase of an ionic lyotropic system. We measured
the relaxation rate of in-plane (undulation) fluctuations as a function of the
wave vector. Static and dynamic results obtained during the same experiment
were combined to yield the values of both elastic constants of the lamellar
phase (compression and bending moduli) as well as that of the sliding
viscosity. The results are in very good agreement with dynamic light-scattering
data, validating the use of the technique in ordered phases