pinecone/core-2020-05-10-deduplication huggingface dataset:
Design and field evaluation of REMPAD: a recommender system supporting group reminiscence therapy

This paper describes a semi-automated web-based system to facilitate digital remi-niscence therapy for patients with mild-to-moderate dementia, enacted in a group setting. The system, REMPAD, uses proactive recommendation technology to profile participants and groups, and offers interactive multimedia content from the Internet to match these profiles. In this paper, we focus on the design of the system to deliver an innovative personalized group reminiscence experience. We take a user-centered design approach to discover and address the design challenges and considerations. A combination of methodologies is used throughout this research study, including exploratory interviews, prototype use case walkthroughs, and field evaluations. The results of the field evaluation indicate high user satisfaction when using the system, and strong tendency towards repeated use in future. These studies provide an insight into the current practices and challenges of group reminiscence therapy, and inform the design of a multimedia recommender system to support facilitators and group therapy participants
Combining Computational and Biochemical Studies for a Rationale on the Anti-Aromatase Activity of Natural Polyphenols

Aromatase, an enzyme of the cytochrome P450 family, is a very important pharmacological target, particularly for the treatment of breast cancer. The anti-aromatase activity of a set of natural polyphenolic compounds was evaluated in vitro. Strong aromatase inhibitors including flavones, flavanones, resveratrol, and oleuropein, with activities comparable to that of the reference anti-aromatase drug aminoglutethimide, were identified. Through the application of molecular modeling techniques based on grid-independent descriptors and molecular interaction fields, the major physicochemical features associated with inhibitory activity were disclosed, and a putative virtual active site of aromatase was proposed. Docking of the inhibitors into a 3D homology model structure of the enzyme defined a common binding mode for the small molecules under investigation. The good correlation between computational and biological results provides the first rationalization of the anti-aromatase activity of polyphenolic compounds. Moreover, the information generated in this approach should be further exploited for the design of new aromatase inhibitors.http://dx.doi.org/10.1002/cmdc.20070014
Trehalose biosynthesis in Thermus thermophilus RQ-1: biochemical properties of the trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase

The genes for trehalose synthesis in Thermus thermophilus RQ-1, namely otsA [trehalose-phosphate synthase (TPS)], otsB [trehalose-phosphate phosphatase (TPP)], and treS [trehalose synthase (maltose converting) (TreS)] genes are structurally linked. The TPS/TPP pathway plays a role in osmoadaptation, since mutants unable to synthesize trehalose via this pathway were less osmotolerant, in trehalose-deprived medium, than the wild-type strain. The otsA and otsB genes have now been individually cloned and overexpressed in Escherichia coli and the corresponding recombinant enzymes purified. The apparent molecular masses of TPS and TPP were 52 and 26 kDa, respectively. The recombinant TPS utilized UDP-glucose, TDP-glucose, ADP-glucose, or GDP-glucose, in this order as glucosyl donors, and glucose-6-phosphate as the glucosyl acceptor to produce trehalose-6-phosphate (T6P). The recombinant TPP catalyzed the dephosphorylation of T6P to trehalose. This enzyme also dephosphorylated G6P, and this activity was enhanced by NDP-glucose. TPS had an optimal activity at about 98°C and pH near 6.0; TPP had a maximal activity near 70°C and at pH 7.0. The enzymes were extremely thermostable: at 100°C, TPS had a half-life of 31 min, and TPP had a half-life of 40 min. The enzymes did not require the presence of divalent cations for activity; however, the presence of Co 2+ and Mg 2+ stimulates both TPS and TPP. This is the first report of the characterization of TPS and TPP from a thermophilic organism.http://dx.doi.org/10.1007/s00792-004-0421-
The role of a firm's absorptive capacity and the technology transfer process in clusters: How effective are technology centres in low-tech clusters?

This paper analyses how the internal resources of small- and medium-sized enterprises determine access (learning processes) to technology centres (TCs) or industrial research institutes (innovation infrastructure) in traditional low-tech clusters. These interactions basically represent traded (market-based) transactions, which constitute important sources of knowledge in clusters. The paper addresses the role of TCs in low-tech clusters, and uses semi-structured interviews with 80 firms in a manufacturing cluster. The results point out that producer–user interactions are the most frequent; thus, the higher the sector knowledge-intensive base, the more likely the utilization of the available research infrastructure becomes. Conversely, the sectors with less knowledge-intensive structures, i.e. less absorptive capacity (AC), present weak linkages to TCs, as they frequently prefer to interact with suppliers, who act as transceivers of knowledge. Therefore, not all the firms in a cluster can fully exploit the available research infrastructure, and their AC moderates this engagement. In addition, the existence of TCs is not sufficient since the active role of a firm's search strategies to undertake interactions and conduct openness to available sources of knowledge is also needed. The study has implications for policymakers and academia
Scaling of Power Corrections for Angularities from Dressed Gluon
  Exponentiation

We study power corrections to a recently introduced family of event shapes,
the class of angularities, within the formalism of dressed gluon exponentiation
(DGE). We find that the universal scaling rule for the leading power
corrections deduced from resummation also holds when taking renormalon
enhancements into account. The scaling is due to boost invariance of eikonal
dynamics in the two-jet limit, which we recover in the context of DGE.
Furthermore, dressed gluon exponentiation provides an ansatz for non-leading
power corrections that violate the scaling. These non-leading corrections are
further suppressed by non-integer powers of the hard scale.Comment: 24 page
Suppression of the thermal hysteresis in magnetocaloric MnAs thin film
  by highly charged ion bombardment

We present the investigation on the modifications of structural and magnetic
properties of MnAs thin film epitaxially grown on GaAs induced by slow highly
charged ions bombardment under well-controlled conditions. The ion-induced
defects facilitate the nucleation of one phase with respect to the other in the
first-order magneto-structural MnAs transition with a consequent suppression of
thermal hysteresis without any significant perturbation on the other structural
and magnetic properties. In particular, the irradiated film keeps the giant
magnetocaloric effect at room temperature opening new perspective on magnetic
refrigeration technology for everyday use
Partition functions and the continuum limit in Penner matrix models

We present an implementation of the method of orthogonal polynomials which is
particularly suitable to study the partition functions of Penner random matrix
models, to obtain their explicit forms in the exactly solvable cases, and to
determine the coefficients of their perturbative expansions in the continuum
limit. The method relies on identities satisfied by the resolvent of the Jacobi
matrix in the three-term recursion relation of the associated families of
orthogonal polynomials. These identities lead to a convenient formulation of
the string equations. As an application, we show that in the continuum limit
the free energy of certain exactly solvable models like the linear and double
Penner models can be written as a sum of gaussian contributions plus linear
terms. To illustrate the one-cut case we discuss the linear, double and cubic
Penner models, and for the two-cut case we discuss theoretically and
numerically the existence of a double-branch structure of the free energy for
the gaussian Penner model
A bidirectional path-finding algorithm and data structure for maritime routing

Route planning is an important problem for many real-time applications in open and
complex environments. The maritime domain is a relevant example of such environments where dynamic phenomena and navigation constraints generate difficult route finding problems. This paper develops a spatial data structure that supports the search for an optimal route between two locations while minimizing a cost function. Although various search algorithms have been proposed so far (e.g. breadth-first search, bidirectional breadth-first search, Dijkstra’s algorithm, A*, etc.), this approach provides a bidirectional dynamic routing algorithm which is based on hexagonal meshes and an iterative deepening A* (IDA*) algorithm, and a front to front strategy using a dynamic graph that facilitates data accessibility. The whole approach is applied to the context of maritime navigation, taking into account navigation hazards and restricted areas. The algorithm developed searches for optimal routes while minimizing
distance and computational time
An LP-based inconsistency monitoring of pairwise comparison matrices

A distance-based inconsistency indicator, defined by the third author for the
consistency-driven pairwise comparisons method, is extended to the incomplete
case. The corresponding optimization problem is transformed into an equivalent
linear programming problem. The results can be applied in the process of
filling in the matrix as the decision maker gets automatic feedback. As soon as
a serious error occurs among the matrix elements, even due to a misprint, a
significant increase in the inconsistency index is reported. The high
inconsistency may be alarmed not only at the end of the process of filling in
the matrix but also during the completion process. Numerical examples are also
provided
Comparison of frequency, risk factors, and time course of postoperative delirium in octogenarians after transcatheter aortic valve implantation versus surgical aortic valve replacement

Postoperative delirium (PD) after transcatheter aortic valve implantation (TAVI) remains to be explored. We sought to (1) determine the incidence of PD in octogenarians who underwent TAVI or surgical aortic valve replacement (SAVR), (2) identify its risk factors, and (3) describe possible differences in the onset and course of PD between treatment groups. A prospective cohort study of consecutive patients aged ≥80 years with severe aortic stenosis who underwent elective TAVI or SAVR (N = 143) was conducted. The incidence of PD was assessed for 5 days using the Confusion Assessment Method (CAM). Risk factors for PD were studied with logistic regression. Patients treated with TAVI were older (p ≤0.001), had lower cognitive scores (p = 0.007), and more co-morbidities (p = 0.003). Despite this, significantly fewer (p = 0.013) patients treated with TAVI (44%) experienced PD compared to patients treated with SAVR (66%). Undergoing SAVR (p = 0.02) and having lower cognitive function (p = 0.03) emerged as risk factors for PD, whereas gender, activities of daily living, frailty, atrial fibrillation, and postoperative use of opioids and anxiolytics did not. Patients treated with TAVI and without PD during the first 2 postoperative days were unlikely to experience PD on subsequent days. The onset of PD after SAVR could occur at any time during the postoperative evaluation. In conclusion, SAVR in octogenarian patients with aortic stenosis might be considered as a predisposing factor for PD. Our data also suggest that the onset of PD was more unpredictable after SAVR
Which evolutionary model best explains the culture of honour?

The culture of honour hypothesis offers a compelling example of how human psychology differentially adapts to pastoral and horticultural environments. However, there is disagreement over whether this pattern is best explained by a memetic, evolutionary psychological, dual inheritance, or niche construction model. I argue that this disagreement stems from two shortcomings: lack of clarity about the theoretical commitments of these models and inadequate comparative data for testing them. To resolve the first problem, I offer a theoretical framework for deriving competing predictions from each of the four models. In particular, this involves a novel interpretation of the difference between dual inheritance theory and cultural niche construction. I then illustrate a strategy for testing their predictions using data from the Human Relations Area File. Empirical results suggest that the aggressive psychological phenotype typically associated with honour culture is more common among pastoral societies than among horticultural societies. Theoretical considerations suggest that this pattern is best explained as a case of cultural niche construction
Input-Output Modeling

Input-output modeling activities have been sponsored by IIASA for many years. These activities provided a link between various research centers as well as associated research groups engaged in constructing similar systems, and also individual researchers interested in the application of input-output type models. \ud
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The aim of the sixth IIASA meeting was to demonstrate to a wide community of researchers, policy makers and their advisers the likely uses of integrated input-output models in economic policy both at industrial and national levels. This message is well illustrated. The papers provide the users with  illuminating simulation studies showing on the one hand the impact of  technological structural changes in the macroaggregates and on the other hand how the changes in macrovariables influence the pattern of changes in  particular industries. \ud
\ud
This volume presents the results of the meeting organized by IIASA and IES in Warsaw
The effect of the geomagnetic field on cosmic ray energy estimates and large scale anisotropy searches on data from the Pierre Auger Observatory

We present a comprehensive study of the influence of the geomagnetic field on the energy estimation of extensive air showers with a zenith angle smaller than 60°, detected at the Pierre Auger Observatory. The geomagnetic field induces an azimuthal modulation of the estimated energy of cosmic rays up to the ~ 2% level at large zenith angles. We present a method to account for this modulation of the reconstructed energy. We analyse the effect of the modulation on large scale anisotropy searches in the arrival direction distributions of cosmic rays. At a given energy, the geomagnetic effect is shown to induce a pseudo-dipolar pattern at the percent level in the declination distribution that needs to be accounted for
How the Scalar Field of Unified Dark Matter Models Can Cluster

We use scalar-field Lagrangians with a non-canonical kinetic term to obtain
unified dark matter models where both the dark matter and the dark energy, the
latter mimicking a cosmological constant, are described by the scalar field
itself. In this framework, we propose a technique to reconstruct models where
the effective speed of sound is small enough that the scalar field can cluster.
These models avoid the strong time evolution of the gravitational potential and
the large Integrated Sachs-Wolfe effect which have been a serious drawback of
previously considered models. Moreover, these unified dark matter scalar field
models can be easily generalized to behave as dark matter plus a dark energy
component behaving like any type of quintessence fluid
DTM-based morphometry of the Palinuro seamount (Eastern Tyrrhenian Sea): Geomorphological and volcanological implications

We present a high resolution DTM of the Palinuro Seamount (PS, Tyrrhenian Sea, Italy) resulting from the
processing of multibeam swath bathymetry records acquired during the second leg of the “Aeolian 2007”
cruise. PS consists of several superimposed volcanoes aligned along a N100°E strike and measures
55×25 km. The western and the central sectors result from the coalescence of collapse structures (calderas)
with younger volcanic cones. The eastern sector reveals a more complex and articulated structure. In the
central sector, a volcanic crater with a well-preserved rim not obliterated by erosional events suggests a
volcanological rejuvenation of this sector. The presence of flat surfaces on the top of the seamount may be
due to the formation of marine terraces during the last sea-level lowering. Lateral collapses on the northern
and southern flanks of the seamount are probably related to slope instability, as suggested by the presence of
steep slopes (25–40°). The main fault affecting PS strikes N65°E and shows a right lateral component of
movement. E–W and N10°E striking faults are also present.
Assuming that theN100°E deep-seated fault,which is responsible for theemplacement of PS,movedwith sinistral
slips, we interpret the N65°E and the N10°E faults as right-lateral (second order) shear and left-lateral (third
order) shear, respectively. Due to the particular location of the Palinuro Seamount, the data presented here allow
us to better understand the volcanism and the geodynamic processes of the Tyrrhenian Sea
Impression management and organizational audiences: The Fiat Group case

Author's accepted manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/s10551-013-1991-9In this paper we investigate whether, and how, corporate management strategically uses disclosure to manage the perceptions of different organizational audiences. In particular, we examine the interactions between the FIAT Group and three of its key organizational audiences—the local press, the international press, and the financial analysts, which are characterized by different levels of salience for the company. We focus on both how management reacts to the optimism level existing within each audience and how the narrative disclosure tone adopted by FIAT influences the ex-post optimism in the local and international press or in the financial analyst community. We investigate the disclosure of the FIAT Group over a 6-year period (2004–2009), during which 70 price-sensitive press releases were published. On the basis of 1,887 (331) news articles published in Italian (international) newspapers and 411 analyst reports, we report evidence of different strategic patterns in the interaction processes between FIAT and its audiences. Our findings also indicate some differences in the way FIAT is affected by, and in turn, affects the sentiment of each audience, thus highlighting that the salience of the stakeholder is an important driver of the adoption of impression management techniques. Taken together, our findings point to issues related to setting the “tone at the top” and potential ethical matters. Copyright Springer Science+Business Media Dordrecht 2015Italian Ministry of Research (MIUR
Study and comparison of the decay modes of the systems formed in the reactions $^{78}$Kr+$^{40}$Ca and $^{86}$Kr+$^{48}$Ca at 10 AMeV

The first results of the ISODEC experiment, performed at the INFN-Laboratori Nazionali del Sud (LNS) by using the CHIMERA detector, will be presented. The principal aims of this experiment is to study the competition between the various disintegration modes of 118,134Ba compound nuclei produced in the reactions 78Kr+40Ca and 86Kr+48Ca at 10 AMeV, exploring the isospin dependence of the decay modes of medium mass compound nuclei formed by fusion processes. The experiment complements data already obtained at 5.5 MeV/A for 78,82Kr+40Ca reactions [1], previously realized with beams delivered by GANIL facility and by using the INDRA detector. The studied systems allow to produce compound nuclei with a large variation of N/Z, at very high angular momentum, and with similar excitation energy. Indeed, the neutron enrichment of the compound nuclei is expected to play an important role on the various emission mechanisms, providing crucial information on fundamental nuclear quantities as level density, fission barrier or viscosity. First results show evident staggering effects in the Z distributions, as well as different isotopic composition and enrichment for the reaction products in the two systems. Absolute cross sections calculations of the reaction products are in progress, to provide important indication on the isospin influence on the reaction mechanism and fragments production. Such a set of data will in fact provide new constraint on sophisticated models attempting to describe statistical and/or dynamical properties [2] of excited nuclei
Hashish Revival in Morocco

International audienceBackground: In less than a decade, Morocco reportedly saw cannabis cultivation decrease by 65 %, and hashish production is widely believed to have followed the same trend. Yet large anomalies exist between the alleged fall of hashish production in Morocco and international seizure data. While no explanation for such a discrepancy existed, the main hypothesis was that cannabis cultivation and hashish production had not declined to the extent suggested by the available information. Methods: Based on existing data, on interviews with various actors, from European police sources to Moroccan cannabis cultivators, and on field research in Morocco, this article reviews contradictory available data and confronts it with observations made in the field. Results: In the past decade cannabis cultivation underwent radical changes that could explain the discrepancy between official Moroccan cultivation and production data on the one hand, and international seizures on the other hand. The "traditional" kif cannabis variety is being rapidly replaced by hybrids with much larger resin yields and much higher potency. This unnoticed phenomenon, which slowly started in the early 2000s, explains how a two-third decline in cannabis cultivation was at least partially compensated for by three to fivefold yield increases. Conclusion: The fact that the massive ongoing switch to hybrid cultivation is largely unknown or unaccounted for is actually a serious issue, for it directly questions the economic strategies that are being implemented in part to reduce and suppress cannabis cultivation in the Rif
Numerical modeling of long-term earthquake sequences on the NE Japan megathrust: comparison with observations and implications for fault friction

International audienceWe use numerical modeling to investigate fault properties that explain key features of the 2011 Mw 9.0 Tohoku-Oki earthquake as well as the overall regional behavior of the NE Japan Megathrust. In particular, we study the possibility that slip near the trench resulted from thermal pressurization on a shallow patch of the megathrust, and investigate whether low-velocity friction on that patch is rate-strengthening or rate-weakening. Our models also contain a deeper rate-weakening patch, not prone to efficient thermal pressurization, to account for the moderate-sized interplate seismicity. We produce earthquake sequences and aseismic slip in our models using 2D dynamic simulations that incorporate shear-induced temperature variations and the associated change in pore fluid pressure to capture thermal pressurization. We find that all our models can reproduce more frequent deeper moderate (Mw 7.5) events and less frequent larger events with substantial slip at shallow depth, as observed along the Fukushima-Miyagi segment of the Japan megathrust. However, only the scenario with a sufficiently rate-strengthening patch can match th