pinecone/core-2020-05-10-deduplication huggingface dataset:
Post-streptococcal glomerulonephritis is a strong risk factor for chronic kidney disease in later life

Although unusual in western countries and in Australia in general, post-streptococcal glomerulonephritis (PSGN) is still common in Australian Aboriginal children living in remote communities. Here, we evaluated whether episodes of acute PSGN increased the risk for chronic kidney disease in later life in 1519 residents of a remote Aboriginal community (85% of those age eligible), with high rates of renal and cardiovascular disease, who participated in a health screen over a 3-year period. Of these, 200 had had at least one episode of PSGN, with 27 having had multiple episodes, usually in childhood. High levels of albuminuria (albumin/creatinine ratio) with increasing age were confirmed. All PSGN episodes were associated with group A streptococcal skin infections, often related to scabies. In both genders, aged 10-39 years at screening, about one in five had such a history. Among them, PSGN (5 years or more earlier) was significantly associated with higher levels of albuminuria than those without. In women, aged 30-39 years, a history of PSGN was associated with a significantly higher frequency of estimated glomerular filtration rates < 60 ml/min. The adjusted odds ratios for an albumin/creatinine ratio over 34 g/mol (overt albuminuria) in males and females with a history of PSGN were 4.6 and 3.1, respectively, compared with those without a history. Thus, PSGN contributes to the very serious burden of chronic kidney disease in this community. Rigorous strategies to prevent scabies and Group A streptococcal infections will reduce this burden
Merging allosteric and active site binding motifs : de novo generation of target selectivity and potency via natural-product-derived fragments

The de novo design of molecules from scratch with tailored biological activity is still the major intellectual challenge in chemical biology and drug discovery. Herein we validate natural-product-derived fragments (NPDFs) as excellent molecular seeds for the targeted de novo discovery of lead structures for the modulation of therapeutically relevant proteins. The application of this de novo approach delivered, in synergy with the combination of allosteric and active site binding motifs, highly selective and ligand-efficient non-zinc-binding (3: 4-{[5-(2-{[(3-methoxyphenyl)methyl]carbamoyl}eth-1-yn-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl]methyl}benzoic acid) as well as zinc-binding (4: 4-({5-[2-({[3-(3-carboxypropoxy)phenyl]methyl}carbamoyl)eth-1-yn-1-yl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzoic acid) uracil-based MMP-13 inhibitors presenting IC50 values of 11 nM (3: LE=0.35) and 6 nM (4: LE=0.31)
Adaptation to Low Salinity Promotes Genomic Divergence in Atlantic Cod (Gadus morhua L.)

-How genomic selection enables species to adapt to divergent environments is a fundamental question in ecology and evolution. We investigated the genomic signatures of local adaptation in Atlantic cod (Gadus morhua L.) along a natural salinity gradient, ranging from 35‰ in the North Sea to 7‰ within the Baltic Sea. By utilizing a 12 K SNPchip, we simultaneously assessed neutral and adaptive genetic divergence across the Atlantic cod genome. Combining outlier analyses with a landscape genomic approach, we identified a set of directionally selected loci that are strongly correlated with habitat differences in salinity, oxygen, and temperature. Our results show that discrete regions within the Atlantic cod genome are subject to directional selection and associated with adaptation to the local environmental conditions in the Baltic- and the North Sea, indicating divergence hitchhiking and the presence of genomic islands of divergence. We report a suite of outlier single nucleotide polymorphisms within or closely located to genes associated with osmoregulation, as well as genes known to play important roles in the hydration and development of oocytes. These genes are likely to have key functions within a general osmoregulatory framework and are important for the survival of eggs and larvae, contributing to the buildup of reproductive isolation between the low-salinity adapted Baltic cod and the adjacent cod populations. Hence, our data suggest that adaptive responses to the environmental conditions in the Baltic Sea may contribute to a strong and effective reproductive barrier, and that Baltic cod can be viewed as an example of ongoing speciation
Digital work design : the interplay of human and computer in future work practices as an interdisciplinary (grand) challenge

Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)More and more academic studies and practitioner reports claim that human work is increasingly disrupted or even determined by information and communication technology (ICT) (Cascio and Montealegre 2016). This will make a considerable share of jobs currently performed by humans susceptible to automation (e.g., Frey and Osborne 2017; Manyika et al. 2017). These reports often sketch a picture of ‘machines taking over’ traditional domains like manufacturing, while ICT advances and capabilities seem to decide companies’ fate. Consequently, ICT is often put at the core of innovative efforts. While this applies to nearly all areas of workplace design, a recent popular example of increasing technology centricity is ‘Industry 4.0’, which is often delineated as ‘machines talking to computers’
Supervised Associative Learning in Spiking Neural Network

In this paper, we propose a simple supervised associative learning approach for spiking neural networks. In an excitatory-inhibitory network paradigm with Izhikevich spiking neurons, synaptic plasticity is implemented on excitatory to excitatory synapses dependent on both spike emission rates and spike timings. As results of learning, the network is able to associate not just familiar stimuli but also novel stimuli observed through synchronised activity within the same subpopulation and between two associated subpopulations
Ice sheets and nitrogen

Snow and ice play their most important role in the nitrogen cycle as a barrier to land–atmosphere and ocean–atmosphere exchanges that would otherwise occur. The inventory of nitrogen compounds in the polar ice sheets is approximately 260 Tg N, dominated by nitrate in the much larger Antarctic ice sheet. Ice cores help to inform us about the natural variability of the nitrogen cycle at global and regional scale, and about the extent of disturbance in recent decades. Nitrous oxide concentrations have risen about 20 per cent in the last 200 years and are now almost certainly higher than at any time in the last 800 000 years. Nitrate concentrations recorded in Greenland ice rose by a factor of 2–3, particularly between the 1950s and 1980s, reflecting a major change in NOx emissions reaching the background atmosphere. Increases in ice cores drilled at lower latitudes can be used to validate or constrain regional emission inventories. Background ammonium concentrations in Greenland ice show no significant recent trend, although the record is very noisy, being dominated by spikes of input from biomass burning events. Neither nitrate nor ammonium shows significant recent trends in Antarctica, although their natural variations are of biogeochemical and atmospheric chemical interest. Finally, it has been found that photolysis of nitrate in the snowpack leads to significant re-emissions of NOx that can strongly impact the regional atmosphere in snow-covered areas
EU-CargoXpress: wind propulsion concept

The EU-CargoXpress project suggests the usage of sustainable energies to reduce the fuel consumption. The updated concept consists of hoisting the superstructure and using it as a sail together with the conventional propulsion. This paper presents the study of the sail performance by means of a computational analysis and wind tunnel tests. Moreover, a research of the energy saving in different operational areas has been conducted. It is concluded that there is a significant energy saving by using the superstructure as a sail which leads to a reduction of fossil fuel consumption and consequently, a reduction of greenhouse gas emissions
Age estimation of adolescent and young adult male and female skeletons II, epiphyseal union at the upper limb and scapular girdle in a modern Portuguese skeletal sample

This study completes previously reported ages for timing of epiphyseal union in the postcranial skeleton in a recent sample, with data from the scapula, clavicle, humerus, radius, and ulna. A sample of 121 individuals between the ages of 9 and 29 (females = 65, males = 56) was derived from the Lisbon documented skeletal collection. Epiphyseal union was scored at 16 anatomical locations, using a three-stage scheme: 1) no union; 2) partial union; and 3) completed union, all traces of fusion having disappeared. In the upper limb, the epiphyses of the elbow are the first to fuse at around 11 to 15 years of age, followed by those of the shoulder and wrist. In the scapular girdle, the coracoid area is the first to fuse, followed by the glenoid surface and remaining epiphyses, with the medial clavicle fusing last, by the age of 25-27. There is a sex difference in maturation, with females showing an advance relative to males of about 2 years in the upper limb. Sex differences in maturation are less noticeable in the scapular girdle, but data suggest that females are also ahead of males. Results suggest overall similar age ranges for stages of union as previous dry bone observations, but some studies show significant divergences which seem to derive from methodological issues. Although some radiographic reference standards provide comparable age ranges, they should probably be avoided when aging skeletal remains. Am J Phys Anthropol, 2008. © 2008 Wiley-Liss, Inc.http://dx.doi.org/10.1002/ajpa.2085
Ring-testing and Field-validation of a Terrestrial Model Ecosystem(TME) – An Instrument for Testing Potentially Harmful Substances: Effects of Carbendazim on Organic Matter Breakdown and Soil Fauna Feeding Activity

Organic matter (OM) decomposition and soil fauna feeding activity were integrated as functional endpoints into ecotoxicological tests with intact-soil-core Terrestrial Model Ecosystems (TMEs). Cellulose filter paper served as standardized OM and was either inserted into the top soil or placed on the soil surface for a period of up to 16 weeks. Faunal feeding activity was assessed by the bait-lamina method. The fungicide carbendazim, applied at six dosages ranging from 0.36 kg/ha to 87.5 kg a.i./ha, served as a model chemical. To validate the results from the TME test, a field study was run in parallel. In TMEs the cellulose paper inserted into the soil was decomposed faster than under field conditions. The carbendazim-induced effects on OM decomposition in TMEs and in the field were comparable and followed a clear dose–response relationship. The calculated EC50 values after 8 weeks of incubation were 9.5, 7.1 and 2.1 kg carbendazim/ha for grassland TMEs, grassland field and arable TMEs, respectively. The feeding activity of the soil fauna showed a large variability. The EC50 values for the effect of carbendazim on bait-lamina consumption ranged between 2.0 and 56 kg a.i./ha. Effects on decomposition were correlated with effects on enchytraeids and earthworms but not with effects on bait-lamina consumption.http://dx.doi.org/10.1023/B:ECTX.0000012410.99020.9
Connes' embedding problem and Tsirelson's problem

We show that Tsirelson's problem concerning the set of quantum correlations and Connes' embedding problem on finite approximations in von Neumann algebras (known to be equivalent to Kirchberg's QWEP conjecture) are essentially equivalent. Specifically, Tsirelson's problem asks whether the set of bipartite quantum correlations generated between tensor product separated systems is the same as the set of correlations between commuting C*-algebras. Connes' embedding problem asks whether any separable II$_1$ factor is a subfactor of the ultrapower of the hyperfinite II$_1$ factor. We show that an affirmative answer to Connes' question implies a positive answer to Tsirelson's. Conversely, a positve answer to a matrix valued version of Tsirelson's problem implies a positive one to Connes' problem
Anticorrelation between Ion Acceleration and Nonlinear Coherent Structures from Laser-Underdense Plasma Interaction

In laser-plasma experiments, we observed that ion acceleration from the Coulomb explosion of the plasma channel bored by the laser, is prevented when multiple plasma instabilities such as filamentation and hosing, and nonlinear coherent structures (vortices/post-solitons) appear in the wake of an ultrashort laser pulse. The tailoring of the longitudinal plasma density ramp allows us to control the onset of these insabilities. We deduced that the laser pulse is depleted into these structures in our conditions, when a plasma at about 10% of the critical density exhibits a gradient on the order of 250 {\mu}m (gaussian fit), thus hindering the acceleration. A promising experimental setup with a long pulse is demonstrated enabling the excitation of an isolated coherent structure for polarimetric measurements and, in further perspectives, parametric studies of ion plasma acceleration efficiency
Quasiparticle interference in an iron-based superconductor

We develop a model for the effect of a magnetic field on quasiparticle
interference in an iron-based superconductor. Recently, scanning tunneling
experiments have been performed on Fe(Se,Te) to determine the relative sign of
the superconducting gap from the magnetic-field dependence of quasiparticle
scattering amplitudes. Using a simple two-band BCS model, we study three
different cases of scattering in a spin-split spectrum. The dominant effect of
a magnetic field in iron-based superconductors is caused by the Pauli limiting
of conduction electrons. Thereby time reversal odd scattering is induced which
enhances the sign-preserving and depresses the sign-reversing peaks in the
quasiparticle interference patterns.Comment: final version, some changes in the tex
A new generation photodetector for astroparticle physics: the VSiPMT

The VSiPMT (Vacuum Silicon PhotoMultiplier Tube) is an innovative design we
proposed for a revolutionary photon detector. The main idea is to replace the
classical dynode chain of a PMT with a SiPM (G-APD), the latter acting as an
electron detector and amplifier. The aim is to match the large sensitive area
of a photocathode with the performance of the SiPM technology. The VSiPMT has
many attractive features. In particular, a low power consumption and an
excellent photon counting capability. To prove the feasibility of the idea we
first tested the performance of a special non-windowed SiPM by Hamamatsu (MPPC)
as electron detector and current amplifier. Thanks to this result Hamamatsu
realized two VSiPMT industrial prototypes. In this work, we present the results
of a full characterization of the VSiPMT prototype
Constraints to a Galactic Component of the Ice Cube cosmic neutrino flux
  from ANTARES

The IceCube evidence for cosmic neutrinos in the high-energy starting events
(HESE) sample has inspired a large number of hypothesis on their origin, mainly
due to the poor precision on the measurement of the direction of showering
events. The fact that most of HESE are downward going suggests a possible
Galactic component. This could be originated either by a single point-like
source or to a directional excess from an extended Galactic region. These
hypotheses are reviewed and constrained, using the present available upper
limits from the ANTARES neutrino telescope.
  ANTARES detects $\nu_\mu$ from sources in the Southern sky with an effective
area larger than that providing the IceCube HESE for $E_\nu<60$ TeV and a
factor of about two smaller at 1 PeV. The use of the $\nu_\mu$ signal enables
an accurate measurement of the incoming neutrino direction. The Galactic signal
allowed by the IceCube HESE and the corresponding ANTARES limits are studied in
terms of a power law flux $E^{-\Gamma}$, with spectral index $\Gamma$ ranging
from 2.0 to 2.5 to cover most astrophysical models
Exact Solution of selfconsistent Vlasov equation

An analytical solution of the selfconsistent Vlasov equation is presented. The time evolution is entirely determined by the initial distribution function. The largest Lyapunov exponent is calculated analytically. For special parameters of the model potential positive Lyapunov exponent is possible. This model may serve as a check for numerical codes solving selfconsistent Vlasov equations. The here presented method is also applicable for any system with analytical solution of the Hamilton equation for the formfactor of the potential
Electromagnetic Dissociation of Nuclei in Heavy-Ion Collisions

Large discrepancies have been observed between measured Electromagnetic
Dissociation(ED) cross sections and the predictions of the semiclassical
Weiz\"acker-Williams-Fermi(WWF) method. In this paper, the validity of the
semiclassical approximation is examined. The total cross section for
electromagnetic excitation of a nuclear target by a spinless projectile is
calculated in first Born approximation, neglecting recoil. The final result is
expressed in terms of correlation functions and convoluted densities in
configuration space. The result agrees with the WWF approximation to leading
order(unretarded electric dipole approximation), but the method allows an
analytic evaluation of the cutoff, which is determined by the details of the
electric dipole transition charge density. Using the Goldhaber-Teller model of
that density, and uniform charge densities for both projectile and target, the
cutoff is determined for the total cross section in the nonrelativistic limit,
and found to be smaller than values currently used for ED calculations. In
addition, cross sections are calculated using a phenomenological momentum space
cutoff designed to model final state interactions. For moderate projectile
energies, the calculated ED cross section is found to be smaller than the
semiclassical result, in qualitative agreement with experiment.Comment: 28 page
Recognition of prior learning: exploring the 'knowledge question'

This is an Accepted Manuscript of an article published by Taylor & Francis in International Journal of Lifelong Education on 21 Mar 2013, available online: http://www.tandfonline.com/10.1080/02601370.2013.778072.This article addresses the 'knowledge question' in the Recognition of Prior Learning (RPL) in relation to postgraduate programmes. In contrast to many traditional theorisations of RPL which draw largely on adult and experiential learning theory, the article starts from a position of knowledge differentiation and explores whether the nature of the discipline or knowledge domain offers affordances or barriers to RPL. In an interview survey, academics in a South African higher education institution were asked their views on the feasibility of RPL in relation to postgraduate study in their discipline. Data analysis draws primarily on concepts from Bernstein to identify different forms of knowledge and the ways in which that knowledge might be transformed and formulated as curricula. Findings suggest that the disciplinary context or knowledge domain into which an RPL candidate is seeking access does play a role in determining the feasibility of RPL. However, distinct organisational environments offer affordances and barriers to the implementation of RPL and there is also significant room for the exercise of pedagogic agency. It follows that RPL cannot be reducible to 'one size fits all', but needs to assume different forms in diverse institutional and disciplinary settings. RPL for access to postgraduate study in a university will vary according to the purpose and design of the programme to which the candidate is seeking access. This supports a position that RPL should be seen as a specialised pedagogical practice that provides tools for navigating access to new learning opportunities across diverse contexts
Cr2C3–NiCr VPS thermal spray coatings as candidate for chromium replacement

The present investigation has been carried out with the aim of determining the tribological behavior of a VPS chromium carbide coating both in the as-deposited and heat-treated conditions. A commercial powder of Cr2C3–25% NiCr was sprayed employing a VPS system (Medicoat AG, Switzerland) onto plain low carbon steel coupons. The samples were subsequently annealed for 2 h at 600 °C, 800 °C and 900 °C in Ar. The microstructural characterization was carried out by using SEM and XRD before and after the heat treatment of the samples. SEM observations were employed for determining the degradation mechanisms that took place during the wear tests. When the coated systems rubbed against alumina under a 5 N normal load in air, a progressive change in the mechanism, from a mixed adhesive and abrasive, to a predominant abrasive was observed, as the heat treatment temperature increased. The wear constants were found to be of the order of approximately 10− 6 mm3/N.m, which indicates a wear resistance of nearly 4 times higher in comparison with the wear results reported in the literature for similar coating systems obtained by employing HVOF deposition. However, the heat treatment carried out at 900 °C brought about only 20% increase in the sliding wear resistance of the coated system
Plastic deformation of rough rolling contact: An experimental and numerical investigation

Quantifying the surface roughness evolution in contacts is a crucial step in the fatigue prediction process. Surfaces are initially conditioned by the running-in process and later altered by surface fatigue. The aim of this study is to understand and predict the evolution of the micro-geometry in the first few over-rolling cycles. Numerical predictions are validated by experiments. A major difficulty in understanding surface degradation is the measurement of the surface roughness evolution at the relevant scales. A twin disc micro-test rig, called μMag, was specially designed for this kind of analysis. The μMag allows the “in situ” observation of changes in the disc surface during interrupted tests, thus avoiding dismounting the specimens, which is a major cause of inaccuracy. The new method also maintains the relative position of the two discs. The precision of the measurements allows one to use the initial surface micro-geometry as input for the numerical contact calculation. Thus, the plastic deformation of the surfaces can be measured during the first cycles and compared to the numerical prediction. Results show a very good agreement between numerical predictions and experimental measurements