pinecone/core-2020-05-10-deduplication huggingface dataset:
Solid State Electrochemical Oxidation Mechanisms Of Morin in Aqueous Media

The mechanism of electrochemical oxidation of morin has been studied using cyclic, differential pulse and square-wave voltammetry techniques in aqueous electrolyte with solid, insoluble morin hydrate mechanically transferred to a glassy carbon electrode surface, over a wide pH range. The oxidation mechanism proceeds in sequential steps, related with the hydroxyl groups in the three aromatic rings and the oxidation is pH dependent over part of the pH range the oxidation potentials are shifted to lower values with increasing pH. Oxidation of the 2prime,4primedihydroxy moiety at the B ring of morin occurs first, at very low positive potentials, and is a one electron one proton reversible reaction. The hydroxyl groups oxidized at more positive potentials were shown to undergo an irreversible oxidation reaction.http://dx.doi.org/10.1002/elan.20040315
Chromium(VI) interaction with plant and animal mitochondrial bioenergetics: A comparative study

The mechanism of Cr(VI)-induced toxicity in plants and animals has been assessed for mitochondrial bioenergetics and membrane damage in turnip root and rat liver mitochondria. By using succinate as the respiratory substrate, ADP/O and respiratory control ratio (RCR) were depressed as a function of Cr(VI) concentration. State 3 and uncoupled respiration were also depressed by Cr(VI). Rat mitochondria revealed a higher sensitivity to Cr(VI), as compared to turnip mitochondria. Rat mitochondrial state 4 respiration rate triplicated in contrast to negligible stimulation of turnip state 4 respiration. Chromium(VI) inhibited the activity of the NADH-ubiquinone oxidoreductase (complex I) from rat liver mitochondria and succinate-dehydrogenases (complex II) from plant and animal mitochondria. In rat liver mitochondria, complex I was more sensitive to Cr(VI) than complex II. The activity of cytochrome c oxidase (complex IV) was not sensitive to Cr(VI). Unique for plant mitochondria, exogenous NADH uncoupled respiration was unaffected by Cr(VI), indicating that the NADH dehydrogenase of the outer leaflet of the plant inner membrane, in addition to complexes III and IV, were insensitive to Cr(VI). The ATPase activity (complex V) was stimulated in rat liver mitochondria, but inhibited in turnip root mitochondria. In both, turnip and rat mitochondria, Cr(VI) depressed mitochondrial succinate-dependent transmembrane potential (Deltapsi) and phosphorylation efficiency, but it neither affected mitochondrial membrane permeabilization to protons (H+) nor induced membrane lipid peroxidation. However, Cr(VI) induced mitochondrial membrane permeabilization to K+, an effect that was more pronounced in turnip root than in rat liver mitochondria. In conclusion, Cr(VI)-induced perturbations of mitochondrial bioenergetics compromises energy-dependent biochemical processes and, therefore, may contribute to the basal mechanism underlying its toxic effects in plant and animal cells. © 2002 Wiley Periodicals, Inc. J Biochem Mol Toxicol 16:53-63, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/jbt.10025http://dx.doi.org/10.1002/jbt.1002
Conformational stability of ibuprofen: Assessed by DFT calculations and optical vibrational spectroscopy

A thorough conformational analysis of ibuprofen [2-(4-isobutylphenyl) propionic acid] was carried by out, using density functional theory (DFT) calculations coupled to optical vibrational spectroscopy (both Raman and FTIR). Eight different geometries were found to be energy minima. The relative orientations of the substituent groups in the ibuprofen molecule, which can be considered as a para-substituted phenyl ring, were verified to hardly affect its conformational stability. The internal rotations converting the calculated conformers of ibuprofen were studied and the intramolecular interactions governing the conformational preferences of the molecule were analyzed by quantitative potential energy deconvolution using Fourier type profiles. The harmonic vibrational frequencies and corresponding intensities were calculated for all the conformers obtained, leading to the assignment of the spectra, and evidencing the sole presence of one of the lowest energy conformers in the solid state. Vibrational spectroscopic proof of intermolecular hydrogen bonds between the carboxylic groups of adjacent ibuprofen molecules, leading to the formation of dimers, was also obtained. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:845-859, 2008http://dx.doi.org/10.1002/jps.2100
Partial Tetrasomy of Chromosome 3q and Mosaicism in a Child with Autism

In this report we describe the case of an 11-year-old male with autism and mental retardation, presenting a tetrasomy of chromosome 3q. Cytogenetic analysis showed a mosaic for an unbalanced karyotype consisting of mos46,XY,add(12)(p13.3)(56)/46,XY(45). FISH using WCP and subtelomeric probes identified the extra material on 12p to be an inverted duplication of the distal segment of chromosome 3q. Anomalies in chromosome 3q have not been previously described in association with autism, although association with psychomotor delays and behavior problems has been frequently reported and are here further discussed. This chromosomal 3q segment is therefore likely to include genes involved in specific neurodevelopment pathways, and further analysis of the region is warranted for the identification of the molecular alterations that lead to the autistic features described.http://dx.doi.org/10.1023/A:102294362766
In vitro and in vivo evaluation of an intraocular implant for glaucoma treatment

Implantable disks for glaucoma treatment were prepared by blending poly(ɛ-caprolactone), PCL, poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) and dorzolamide. Their in vivo performance was assessed by their capacity to decrease intraocular pressure (IOP) in normotensive and hypertensive eyes. Drug mapping showed that release was complete from blend disks and the low molecular weight (MW) PCL after 1 month in vivo. The high MW PCL showed non-cumulative release rates above the therapeutic level during 3 months in vitro. In vivo, the fibrous capsule formation around the implant controls the drug release, working as a barrier membrane. Histologic analysis showed normal foreign body reaction response to the implants. In normotensive eyes, a 20% decrease in IOP obtained with the disks during 1 month was similar to Trusopt® eyedrops treatment. In hypertensive eyes, the most sustained decrease was shown by the high MW PCL (40% after 1 month, 30% after 2 months). It was shown that the implants can lower IOP in sustained manner in a rabbit glaucoma model
Automatic summarization of rushes video using bipartite graphs

In this paper we present a new approach for automatic summarization of rushes, or unstructured video. Our approach is composed of three major steps. First, based on shot and sub-shot segmentations, we filter sub-shots with low information content not likely to be useful in a summary. Second, a method using maximal matching in a bipartite graph is adapted to measure similarity between the remaining shots and to minimize inter-shot redundancy by removing repetitive retake shots common in rushes video. Finally, the presence of faces and motion intensity are characterised in each sub-shot. A measure of how representative the sub-shot is in the context of the overall video is then proposed. Video summaries composed of keyframe slideshows are then generated. In order to evaluate the effectiveness of this approach we re-run the evaluation carried out by TRECVid, using the same dataset and evaluation metrics used in the TRECVid video summarization task in 2007 but with our own assessors. Results show that our approach leads to a significant improvement on our own work in terms of the fraction of the TRECVid summary ground truth included and is competitive with the best of other approaches in TRECVid 2007
Real-time gaze estimation using a Kinect and a HD webcam

In human-computer interaction, gaze orientation is an important and promising source of information to demonstrate the attention and focus of users. Gaze detection can also be an extremely useful metric for analysing human mood and affect. Furthermore, gaze can be used as an input method for human-computer interaction. However, currently real-time and accurate gaze estimation is still an open problem. In this paper, we propose a simple and novel estimation model of the real-time gaze direction of a user on a computer screen. This method utilises cheap capturing devices, a HD webcam and a Microsoft Kinect. We consider that the gaze motion from a user facing forwards is composed of the local gaze motion shifted by eye motion and the global gaze motion driven by face motion. We validate our proposed model of gaze estimation and provide experimental evaluation of the reliability and the precision of the method
Using LDP-TOP in video-based spoofing detection

Face authentication has been shown to be vulnerable against three main kinds of attacks: print, replay, and 3D mask. Among those, video replay attacks appear more challenging to be detected. There exist in the literature many countermeasures to face spoofing attacks, but a sophisticated detector is still needed to deal with particularly high-quality video based attacks. In this work, we perform analysis on the noise residual in frequency domain, and extract discriminative features by using a dynamic texture descriptor to characterize video based spoofing attacks. We propose a promising detector, which produces competitive results on the most challenging dataset of video based spoofing
Automatic Inference of Upper Bounds for Recurrence Relations in Cost Analysis

The classical approach to automatic cost analysis consists of two phases. Given a program and some measure of cost, we first produce recurrence relations (RRs) which capture the cost of our program in terms of the size of its input data. Second, we convert such RRs into closed form (i.e., without recurrences). Whereas the first phase has received considerable attention, with a number of cost analyses available for a variety of programming languages, the second phase has received comparatively little attention. In this paper we first study the features of RRs generated by automatic cost analysis and discuss why existing computer algebra systems are not appropriate for automatically obtaining closed form solutions nor upper bounds of them. Then we present, to our knowledge, the first practical framework for the fully automatic generation of reasonably accurate upper bounds of RRs originating from cost analysis of a wide range of programs. It is based on the inference of ranking functions and loop invariants and on partial evaluation
LiDAR simulation in modelled orchards to optimise the use of terretrial laser scanners and derived vegetative measures

Light detection and ranging (LiDAR) technology is beginning to have an impact on agriculture.\ud
Canopy volume and/or fruit tree leaf area can be estimated using terrestrial laser sensors based on this technology. However, the use of these devices may have different options depending on the resolution and scanning mode. As a consequence, data accuracy and LiDAR derived parameters are affected by sensor configuration, and may vary according\ud
to vegetative characteristics of tree crops. Given this scenario, users and suppliers of these devices need to know how to use the sensor in each case. This paper presents a\ud
computer program to determine the best configuration, allowing simulation and evaluation of different LiDAR configurations in various tree structures (or training systems). The ultimate goal is to optimise the use of laser scanners in field operations. The software presented generates a virtual orchard, and then allows the scanning simulation with a laser sensor. Trees are created using a hidden Markov tree (HMT) model. Varying the foliar\ud
structure of the orchard the LiDAR simulation was applied to twenty different artificially created orchards with or without leaves from two positions (lateral and zenith). To validate the laser sensor configuration, leaf surface of simulated trees was compared with the parameters obtained by LiDAR measurements: the impacted leaf area, the impacted total area (leaves and wood), and th impacted area in the three outer layers of leaves
Selective ablation with UV lasers of a-Si:H thin film solar cells in direct scribing configuration

Monolithical series connection of silicon thin-film solar cells modules performed by laser scribing plays a very important role in the entire production of these devices. In the current laser process interconnection the two last steps are developed for a configuration of modules where the glass is essential as transparent substrate. In addition, the change of wavelength in the employed laser sources is sometimes enforced due to the nature of the different materials of the multilayer structure which make up the device. The aim of this work is to characterize the laser patterning involved in the monolithic interconnection process in a different configurations of processing than the usually performed with visible laser sources. To carry out this study, we use nanosecond and picosecond laser sources working at 355nm of wavelength in order to achieve the selective ablation of the material from the film side. To assess this selective removal of material has been used EDX (energy dispersive using X-ray) analysi
Temperature controlled light-emitting diode lamp for photovoltaic rural applications

In recent years, interest in light-emitting diode (LED) lighting has been growing because of its high efficacy, lifetime and ruggedness. This paper proposes a better adaptation of LED lamps to the technical requirements of photovoltaic lighting domestic systems, whose main quality criteria are reliability and that behave as voltage power supplies. As the key element of reliability in LED lamps is temperature, a solution is proposed for driving LED lamps using voltage sources, such as photovoltaic system batteries, with a control architecture based on pulse width modulation signal that regulates the current applied according to the LED lamp temperature. A prototype of the LED lamp has been implemented and tested to show its good performance at different temperatures and at different battery voltages
Effects of conservation interventions on the archaeological Roman site of Merida (Spain). Advance of research.

Research on the assessment of the effects of conservation/restoration treatments on stone material has been significant in recent years, with focus on the early observation of decay caused by the application of these treatments. However, in the case of archaeological sites, research is still scarce and few studies on the subject have been published. Restoration, as everything else, has changed according to trends, mainly guided by the release of new products and technologies, an experimental field where scientific assessment of suitability, efficacy and durability pre-evaluations of treatments are not always conducted. Some efforts have been made to solve this problem in the architectural field, where functional needs and technical requirements force to set clear standards. Unfortunately, archaeological sites, unlike historic buildings, have specific features that preclude the extrapolation of these results. A critical review of the methodologies, products and restoration materials is necessary, coupled with deeper research on degradation mechanisms caused by these treatments in the mid- and long-term. The aim of this paper is to introduce the research on the above issues using Merida as a case study
A partial study of vertical distribution of conventional no-till seeders and spatial variability of seed depth placement of maize in the Alentejo region, Portugal

The requirements for a good stand in a no-till field are the same as those for conventional planting as well as added field and machinery management. Among the\ud
various factors that contribute towards producing a successful maize crop, seed depth placement is a key determinant. Although most no-till planters on the market work well under good soil and residue conditions, adjustments and even modifications are frequently\ud
needed when working with compacted or wet soils or with heavy residues. The main objective of this study, carried out in 2010, 2011 and 2012, was to evaluate the vertical\ud
distribution and spatial variability of seed depth placement in a maize crop under no-till conditions, using precision farming technologies and conventional no-till seeders. The results obtained indicate that the seed depth placement was affected by soil moisture content and forward speed. The seed depth placement was negatively correlated with soil resistance and seeding depth had a significant impact on mean emergence time and the percentage of emerged plants. Shallow average depth values and high coefficients of variation suggest a need for improvements in controlling the seeders’ sowing depth mechanism or more accurate calibration by operators in the field
High-power UV-LED degradation: Continuous and cycled working condition influence

High-power (HP) UV-LEDs can replace UV lamps for real-time fluoro-sensing applications by allowing portable and autonomous systems. However, HP UV-LEDs are not a mature technology, and there are still open issues regarding their performance evolution over time. This paper presents a reliability study of\ud
3W UV-LEDs, with special focus on LED degradation for two working conditions: continuous and cycled (30 s ON and 30 s OFF). Accelerated life tests are developed to evaluate the influence of temperature and electrical working conditions in high-power LEDs degradation, being the predominant failure mechanism the degradation of the package. An analysis that includes dynamic thermal and optical HP UV-LED measurements\ud
has been performed. Static thermal and stress simulation analysis with the finite element method (FEM) identifies the causes of package degradation. Accelerated life test results prove that HP UV-LEDs working in cycled condition have a better performance than those working in continuous condition
Multi-class Boosting for imbalanced data.

We consider the problem of multi-class classification with imbalanced data-sets. To this end, we introduce a cost-sensitive multi-class Boosting algorithm (BAdaCost) based on a generalization of the Boosting margin, termed multi-class cost-sensitive margin. To address the class imbalance we introduce a cost matrix that weighs more hevily the costs of confused classes and a procedure to estimate these costs from the confusion matrix of a standard 0|1-loss classifier. Finally, we evaluate the performance of the approach with synthetic and real data-sets and compare our results with the AdaC2.M1 algorithm
Islands of biogeodiversity in arid lands on a polygons map study: Detecting scale invariance patterns from natural resources maps

Abstract Many maps (geology, hydrology, soil, vegetation, etc.) are created to inventory natural resources. Each of these resources is mapped using a unique set of criteria, including scales and taxonomies. Past research indicates that comparing results of related maps (e.g., soil and geology maps) may aid in identifying mapping deficiencies. Therefore, this study was undertaken in Almeria Province, Spain to (i) compare the underlying map structures of soil and vegetation maps and (ii) investigate if a vegetation map can provide useful soil information that was not shown on a soil map. Soil and vegetation maps were imported into ArcGIS 10.1 for spatial analysis, and results then exported to Microsoft Excel worksheets for statistical analyses to evaluate fits to linear and power law regression models. Vegetative units were grouped according to the driving forces that determined their presence or absence: (i) climatophilous (ii) lithologic-climate; and (iii) edaphophylous. The rank abundance plots for both the soil and vegetation maps conformed to Willis or Hollow Curves, meaning the underlying structures of both maps were the same. Edaphophylous map units, which represent 58.5% of the vegetation units in the study area, did not show a good correlation with the soil map. Further investigation revealed that 87% of the edaphohygrophilous units were found in ramblas, ephemeral riverbeds that are not typically classified and mapped as soils in modern systems, even though they meet the definition of soil given by the most commonly used and most modern soil taxonomic systems. Furthermore, these edaphophylous map units tend to be islands of biodiversity that are threatened by anthropogenic activity in the region. Therefore, this study revealed areas that need to be revisited and studied pedologically. The vegetation mapped in these areas and the soils that support it are key components of the earth's critical zone that must be studied, understood, and preserved
The Rotational Spectrum of Tyrosine

Producción CientíficaIn this work neutral tyrosine has been generated in the gas phase by laser ablation of solid samples, and its most abundant conformers characterized through their rotational spectra. Their identification has been made by comparison between the experimental and ab initio values of the rotational and quadrupole coupling constants. Both conformers are stabilized by an O–H•••N hydrogen bond established within the amino acid skeleton chain and an additional weak N–H•••π hydrogen bond. The observed conformers differ in the orientation of the phenolic −OH group.Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA175U13
Influence of stored elastic strain energy on fatigue behaviour of NiTi shape memory alloy thermal actuator wire

Influence of stored elastic strain energy, Eelse, on thermo-mechanical fatigue behaviour of NiTi shape memory alloy (SMA)thermal actuator wire was investigated.  Two near equi-atomic NiTi SMA wires obtained from different sources were evaluated for quasi-static and functional fatigue properties.  Study showed that the wires had similar chemical composition, transformation temperatures and static\ud
mechanical properties. However, the functional fatigue behaviour of the wires upon thermo-mechanical cycling (TMC) was found to be significantly different.  Under avariable TMC stress in the range 150–450 MPa and 4% recovery strain, one of the wires showed better stability, and substantially\ud
higher fatigue life(~30000cycles)than the other (~3500 cycles).  Thermodynamic and microstructural analyses indicated that the wide variation in fatigue response of the wires was due to difference in magnitude of Eelse in the material. It is observed that at a given temperature above austenite start temperature (As), the wire with higher stored Eelse, generated about 70–100MP a higher recovery stress than that of the wire with lower stored Eelse. As a consequence,the maximum temperature, Tmax,\ud
necessary for generation of preset peak stress during reverse(martensite-austenite)transformation, was always less in the former wire than that of the latter.  This in turn was responsible for wide variations in thermo-mechanical fatigue behaviour of the two wires upon TMC
Dissecting cancer evolution at the macro-heterogeneity and micro-heterogeneity scale

Intratumour heterogeneity complicates biomarker discovery and treatment personalization, and pervasive cancer evolution is a key mechanism leading to therapy failure and patient death. Thus, understanding subclonal heterogeneity architectures and cancer evolution processes is critical for the development of effective therapeutic approaches which can control or thwart cancer evolutionary plasticity. Current insights into heterogeneity are mainly limited to the macroheterogeneity level, established by cancer subclones that have undergone significant clonal expansion. Novel single cell sequencing and blood-based subclonal tracking technologies are enabling detailed insights into microheterogeneity and the dynamics of clonal evolution. We assess how this starts to delineate the rules governing cancer evolution and novel angles for more effective therapeutic intervention