pinecone/core-2020-05-10-deduplication huggingface dataset:
Hartree–Fock many-body perturbation theory for nuclear ground-states

AbstractWe investigate the order-by-order convergence behavior of many-body perturbation theory (MBPT) as a simple and efficient tool to approximate the ground-state energy of closed-shell nuclei. To address the convergence properties directly, we explore perturbative corrections up to 30th order and highlight the role of the partitioning for convergence. The use of a simple Hartree–Fock solution for the unperturbed basis leads to a convergent MBPT series for soft interactions, in contrast to the divergent MBPT series obtained with a harmonic oscillator basis. For larger model spaces and heavier nuclei, where a direct high-order MBPT calculation is not feasible, we perform third-order calculations and compare to advanced ab initio coupled-cluster results for the same interactions and model spaces. We demonstrate that third-order MBPT provides ground-state energies for nuclei up into the tin isotopic chain in excellent agreement with the best available coupled-cluster calculations at a fraction of the computational cost
On the constants in a basic inequality for the Euler and Navier–Stokes equations

AbstractWe consider the incompressible Euler or Navier–Stokes (NS) equations on a d-dimensional torus Td; the quadratic term in these equations arises from the bilinear map sending two velocity fields v,w:Td→Rd into v⋅∂w, and also involves the Leray projection L onto the space of divergence free vector fields. We derive upper and lower bounds for the constants in two inequalities related to the above quadratic term; these bounds hold, in particular, for the sharp constants Knd≡Kn in the basic inequality ‖L(v⋅∂w)‖n⩽Kn‖v‖n‖w‖n+1, where n∈(d/2,+∞) and v,w are in the Sobolev spaces HΣ0n,HΣ0n+1 of zero mean, divergence free vector fields of orders n and n+1, respectively. As examples, the numerical values of our upper and lower bounds are reported for d=3 and some values of n. Some practical motivations are indicated for an accurate analysis of the constants Kn, making reference to other works on the approximate solutions of Euler or NS equations
The Zee–Babu model revisited in the light of new data

AbstractWe update previous analyses of the Zee–Babu model in the light of new data, e.g., the mixing angle θ13, the rare decay μ→eγ and the LHC results. We also analyze the possibility of accommodating the deviations in Γ(H→γγ) hinted by the LHC experiments, and the stability of the scalar potential. We find that neutrino oscillation data and low energy constraints are still compatible with masses of the extra charged scalars accessible to LHC. Moreover, if any of them is discovered, the model can be falsified by combining the information on the singly and doubly charged scalar decay modes with neutrino data. Conversely, if the neutrino spectrum is found to be inverted and the CP phase δ is quite different from π, the masses of the charged scalars will be well outside the LHC reach
Energy–pressure relation for low-dimensional gases

AbstractA particularly simple relation of proportionality between internal energy and pressure holds for scale-invariant thermodynamic systems (with Hamiltonians homogeneous functions of the coordinates), including classical and quantum – Bose and Fermi – ideal gases. One can quantify the deviation from such a relation by introducing the internal energy shift as the difference between the internal energy of the system and the corresponding value for scale-invariant (including ideal) gases. After discussing some general thermodynamic properties associated with the scale-invariance, we provide criteria for which the internal energy shift density of an imperfect (classical or quantum) gas is a bounded function of temperature. We then study the internal energy shift and deviations from the energy–pressure proportionality in low-dimensional models of gases interpolating between the ideal Bose and the ideal Fermi gases, focusing on the Lieb–Liniger model in 1d and on the anyonic gas in 2d. In 1d the internal energy shift is determined from the thermodynamic Bethe ansatz integral equations and an explicit relation for it is given at high temperature. Our results show that the internal energy shift is positive, it vanishes in the two limits of zero and infinite coupling (respectively the ideal Bose and the Tonks–Girardeau gas) and it has a maximum at a finite, temperature-depending, value of the coupling. Remarkably, at fixed coupling the energy shift density saturates to a finite value for infinite temperature. In 2d we consider systems of Abelian anyons and non-Abelian Chern–Simons particles: as it can be seen also directly from a study of the virial coefficients, in the usually considered hard-core limit the internal energy shift vanishes and the energy is just proportional to the pressure, with the proportionality constant being simply the area of the system. Soft-core boundary conditions at coincident points for the two-body wavefunction introduce a length scale, and induce a non-vanishing internal energy shift: the soft-core thermodynamics is considered in the dilute regime for both the families of anyonic models and in that limit we can show that the energy–pressure ratio does not match the area of the system, opposed to what happens for hard-core (and in particular 2d Bose and Fermi) ideal anyonic gases
Kaltofen’s division-free determinant algorithm differentiated for matrix adjoint computation

AbstractKaltofen has proposed a new approach in Kaltofen (1992) for computing matrix determinants without divisions. The algorithm is based on a baby steps/giant steps construction of Krylov subspaces, and computes the determinant as the constant term of the characteristic polynomial. For matrices over an abstract ring, by the results of Baur and Strassen (1983), the determinant algorithm, actually a straight-line program, leads to an algorithm with the same complexity for computing the adjoint of a matrix. However, the latter adjoint algorithm is obtained by the reverse mode of automatic differentiation, and hence is in some way not “explicit”. We present an alternative (still closely related) algorithm for obtaining the adjoint that can be implemented directly, without resorting to an automatic transformation. The algorithm is deduced partly by applying program differentiation techniques “by hand” to Kaltofen’s method, and is completely described. As a subproblem, we study the differentiation of the computation of minimum polynomials of linearly generated sequences, and we use a lazy polynomial evaluation mechanism for reducing the cost of Strassen’s avoidance of divisions in our case
Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting

AbstractThe chief and largely terminal element of normal blood clotting is considered to involve the polymerisation of the mainly α-helical fibrinogen to fibrin, with a binding mechanism involving ‘knobs and holes’ but with otherwise little change in protein secondary structure. We recognise, however, that extremely unusual mutations or mechanical stressing can cause fibrinogen to adopt a conformation containing extensive β-sheets. Similarly, prions can change morphology from a largely α-helical to largely β-sheet conformation, and the latter catalyses both the transition and the self-organising polymerisation of the β-sheet structures. Many other proteins can also do this, where it is known as amyloidogenesis. When fibrin is formed in samples from patients harbouring different diseases it can have widely varying diameters and morphologies. We here develop the idea, and summarise the evidence, that in many cases the anomalous fibrin fibre formation seen in such diseases actually amounts to amyloidogenesis. In particular, fibrin can interact with the amyloid-β (Aβ) protein that is misfolded in Alzheimer's disease. Seeing these unusual fibrin morphologies as true amyloids explains a great deal about fibrin(ogen) biology that was previously opaque, and provides novel strategies for treating such coagulopathies. The literature on blood clotting can usefully both inform and be informed by that on prions and on the many other widely recognised (β-)amyloid proteins. A preprint has been lodged in bioRxiv (Kell and Pretorius, 2016)
Habitual chocolate consumption and the risk of incident heart failure among healthy men and women

AbstractBackgroundWe aimed to examine the association between chocolate intake and the risk of incident heart failure in a UK general population. We conducted a systematic review and meta-analysis to quantify this association.Methods and resultsWe used data from a prospective population-based study, the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort. Chocolate intake was quantified based on a food frequency questionnaire obtained at baseline (1993–1997) and incident heart failure was ascertained up to March 2009. We supplemented the primary data with a systematic review and meta-analysis of studies which evaluated risk of incident heart failure with chocolate consumption. A total of 20,922 participants (53% women; mean age 58 ± 9 years) were included of whom 1101 developed heart failure during the follow up (mean 12.5 ± 2.7 years, total person years 262,291 years). After adjusting for lifestyle and dietary factors, we found 19% relative reduction in heart failure incidence in the top (up to 100 g/d) compared to the bottom quintile of chocolate consumption (HR 0.81 95%CI 0.66–0.98) but the results were no longer significant after controlling for comorbidities (HR 0.87 95%CI 0.71–1.06). Additional adjustment for potential mediators did not attenuate the results further. We identified five relevant studies including the current study (N = 75,408). The pooled results showed non-significant 19% relative risk reduction of heart failure incidence with higher chocolate consumption (HR 0.81 95%CI 0.66–1.01).ConclusionsOur results suggest that higher chocolate intake is not associated with subsequent incident heart failure
Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

SummaryNo methods for isolating induced alveolar epithelial progenitor cells (AEPCs) from human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have been reported. Based on a study of the stepwise induction of alveolar epithelial cells (AECs), we identified carboxypeptidase M (CPM) as a surface marker of NKX2-1+ “ventralized” anterior foregut endoderm cells (VAFECs) in vitro and in fetal human and murine lungs. Using SFTPC-GFP reporter hPSCs and a 3D coculture system with fetal human lung fibroblasts, we showed that CPM+ cells isolated from VAFECs differentiate into AECs, demonstrating that CPM is a marker of AEPCs. Moreover, 3D coculture differentiation of CPM+ cells formed spheroids with lamellar-body-like structures and an increased expression of surfactant proteins compared with 2D differentiation. Methods to induce and isolate AEPCs using CPM and consequently generate alveolar epithelial spheroids would aid human pulmonary disease modeling and regenerative medicine
The axigluon, a four-site model and the top quark forward–backward asymmetry at the Tevatron

AbstractVery recently, it has been shown by other authors that the CDF measurement of the top quark forward–backward asymmetry can be explained by means of a heavy and broad axigluon. In order to work, this mechanism needs that the axigluon coupling to the top quark must be different than the coupling to light quarks and both must be stronger than the one predicted in classical axigluon models. In this Letter, we argue that this kind of axigluon can be accommodated in an extended chiral color model we proposed previously. Additionally, we show that the desired features can be derived from a simple four-site model with delocalized fermions
A live test of automated facies prediction at wells for CO2 storage projects

AbstractAt least 900 m of image log data have been interpreted in detail through the Late Cretaceous and Cenozoic succession intersected at two purpose-drilled injection wells of the CO2CRC Otway Project. Interpretations have been calibrated against core observations where possible. Natural clusters for the combined signature of a common suite of coincident well log data were determined using an unsupervised Naïve Bayesian classification algorithm called Autoclass. A deterministic relationship between these modelled clusters and interpreted image log facies provides a two-step facies prediction algorithm that can be applied using well log data acquired at other wells intersecting sedimentary successions prospective for CO2 storage.Earlier this year the Division of Resources & Energy, Department of Trade & Investment, of the Australian state of New South Wales drilled a new stratigraphic test well within the Pondie Range Trough of the Darling Basin. The new well, Mena Murtee-1, was drilled close to a 2D seismic tie line linking the Pondie Range Trough depocenter with an old petroleum exploration well, Pondie Range-1, that is sited on a flanking high. Analyses and interpretation of data acquired at Mena Murtee-1 is the latest step in reducing the uncertainty surrounding CO2 storage potential within the Darling Basin. Interpretation of core and image log data acquired at the new well has provided a means by which to test facies predictions made on the basis of the models developed within the Otway Basin
Patterns of disease progression in type 2 and 3 SMA: Implications for clinical trials

AbstractThe aim of the study was to establish 12-month changes in the Hammersmith Functional motor scale in a large cohort of SMA patients, to identify patterns of disease progression and the effect of different variables. 268 patients were included in this multicentric study. Their age ranged between 2.5 and 55.5 years at baseline, 68 were ambulant and 200 non-ambulant. The baseline scores ranged between 0 and 66 (mean 23.91, SD 20.09). The 12-month change was between −14 and +9 (mean −0.56, SD 2.72). Of the 268 patients, 206 (76.86%) had changes between −2 and +2 points. Ambulant and non-ambulant subjects had a different relationship between baseline values and age (p for age X ambulation interaction = 0.007). There was no association with age in ambulant subjects, while there was a significant heterogeneity at different age for non-ambulant patients (p < 0.001). The 12-month change (adjusted for baseline) was not associated with age in ambulant patients (p = 0.34), but it was significantly different among various age groups in non-ambulant patients. Our results suggest that there are different profiles of progression in ambulant and non-ambulant patients, and that age may play an important role in the progression of non-ambulant patients
Equations of motion of test particles for solving the spin-dependent Boltzmann–Vlasov equation

AbstractA consistent derivation of the equations of motion (EOMs) of test particles for solving the spin-dependent Boltzmann–Vlasov equation is presented. The resulting EOMs in phase space are similar to the canonical equations in Hamiltonian dynamics, and the EOM of spin is the same as that in the Heisenburg picture of quantum mechanics. Considering further the quantum nature of spin and choosing the direction of total angular momentum in heavy-ion reactions as a reference of measuring nucleon spin, the EOMs of spin-up and spin-down nucleons are given separately. The key elements affecting the spin dynamics in heavy-ion collisions are identified. The resulting EOMs provide a solid foundation for using the test-particle approach in studying spin dynamics in heavy-ion collisions at intermediate energies. Future comparisons of model simulations with experimental data will help to constrain the poorly known in-medium nucleon spin–orbit coupling relevant for understanding properties of rare isotopes and their astrophysical impacts
Comments on the symmetry of AdS6 solutions in string/M-theory and Killing spinor equations

AbstractIt was recently pointed out in [1] that AdS6 solutions in IIB theory enjoy an extended symmetry structure and the consistent truncation to D=4 internal space leads to a nonlinear sigma model with target SL(3,R)/SO(2,1). We continue to study the purely bosonic D=4 effective action, and elucidate how the addition of scalar potential term still allows Killing spinor equations in the absence of gauge fields. In particular, the potential turns out to be a single diagonal component of the coset representative. Furthermore, we perform a general analysis of the integrability conditions of Killing spinor equations and establish that the effective action can be in fact generalized to arbitrary sizes and signatures, e.g. with target SL(n,R)/SO(p,n−p) and the scalar potential expressible by a single diagonal component of the coset representative. We also comment on a similar construction and its generalizations of effective D=5 purely bosonic non-linear sigma model action related to AdS6 in M-theory
Improving arteriovenous fistula patency: Transdermal delivery of diclofenac reduces cannulation-dependent neointimal hyperplasia via AMPK activation

AbstractCreation of an autologous arteriovenous fistula (AVF) for vascular access in haemodialysis is the modality of choice. However neointimal hyperplasia and loss of the luminal compartment result in AVF patency rates of ~60% at 12months. The exact cause of neointimal hyperplasia in the AVF is poorly understood. Vascular trauma has long been associated with hyperplasia. With this in mind in our rabbit model of AVF we simulated cannulation autologous to that undertaken in vascular access procedures and observed significant neointimal hyperplasia as a direct consequence of cannulation. The neointimal hyperplasia was completely inhibited by topical transdermal delivery of the non-steroidal anti-inflammatory (NSAID) diclofenac. In addition to the well documented anti-inflammatory properties we have identified novel anti-proliferative mechanisms demonstrating diclofenac increases AMPK-dependent signalling and reduced expression of the cell cycle protein cyclin D1. In summary prophylactic transdermal delivery of diclofenac to the sight of AVF cannulation prevents adverse neointimal hyperplasic remodelling and potentially offers a novel treatment option that may help prolong AVF patency and flow rates
Forum on Global Land Grabbing Part 2: The politis of evidence: methodologies for understanding the global land rush

The most recent ‘land rush’ precipitated by the convergent ‘crises’ of fuel, feed and food
in 2007–2008 has heightened the debate on the consequences of land investments, with
widespread media coverage, policy commentary and civil society engagement. This
‘land rush’ has been accompanied by a ‘literature rush’, with a fast-growing body of
reports, articles, tables and books with varied purposes, metrics and methods. Land
grabbing, as it is popularly called, is now a hot political topic around the world,
discussed amongst the highest circles. This is why getting the facts right is very
important and having effective methodologies for doing so is crucial. Several global
initiatives have been created to aggregate information on land deals, and to describe
their scale, character and distribution. All have contributed to building a bigger (if not
always better) picture of the phenomenon, but all have struggled with methodology.
This JPS Forum identifies a profound uncertainty about what it is that is being
counted, questions the methods used to collate and aggregate ‘land grabs’, and calls
for a second phase of land grab research which abandons the aim of deriving total
numbers of hectares in favour of more specific, grounded and transparent methods.Department of HE and Training approved lis
Some thoughts on neural network modelling of micro-abrasion-corrosion processes

There is increasing interest in the interactions of microabrasion, involving small particles of less than 10 μm in size, with corrosion. This is because such interactions occur in many environments ranging from the offshore to health care sectors. In particular, micro-abrasion-corrosion can occur in oral processing, where the abrasive components of food interacting with the acidic environment, can lead to degradation of the surface dentine of teeth. Artificial neural networks (ANNs) are computing mechanisms based on the biological brain. They are very effective in various areas such as modelling, classification and pattern recognition. They have been successfully applied in almost all areas of engineering and many practical industrial applications. Hence, in this paper an attempt has been made to model the data obtained in microabrasion-corrosion experiments on polymer/steel couple and a ceramic/lasercarb coating couple using ANN. A multilayer perceptron (MLP) neural network is applied and the results obtained from modelling the tribocorrosion processes will be compared with those obtained from a relatively new class of neural networks namely resource allocation network
The EBLM Project I-Physical and orbital parameters, including spin-orbit
  angles, of two low-mass eclipsing binaries on opposite sides of the Brown
  Dwarf limit

This paper introduces a series of papers aiming to study the dozens of low
mass eclipsing binaries (EBLM), with F, G, K primaries, that have been
discovered in the course of the WASP survey. Our objects are mostly single-line
binaries whose eclipses have been detected by WASP and were initially followed
up as potential planetary transit candidates. These have bright primaries,
which facilitates spectroscopic observations during transit and allows the
study of the spin-orbit distribution of F, G, K+M eclipsing binaries through
the Rossiter-McLaughlin effect. Here we report on the spin-orbit angle of
WASP-30b, a transiting brown dwarf, and improve its orbital parameters. We also
present the mass, radius, spin-orbit angle and orbital parameters of a new
eclipsing binary, J1219-39b (1SWAPJ121921.03-395125.6, TYC 7760-484-1), which,
with a mass of 95 +/- 2 Mjup, is close to the limit between brown dwarfs and
stars. We find that both objects orbit in planes that appear aligned with their
primaries' equatorial planes. Neither primaries are synchronous. J1219-39b has
a modestly eccentric orbit and is in agreement with the theoretical
mass--radius relationship, whereas WASP-30b lies above it.Comment: 12 pages, 7 figures, data in appendices, submitted to A&A (taking in
  account 1st referee report
Search for charged Higgs bosons through the violation of lepton universality in t¯t events using pp collision data at ps = 7 TeV with the ATLAS experiment

In several extensions of the Standard Model, the top quark can decay into a
bottom quark and a light charged Higgs boson H+, t → bH+, in addition to the Standard
Model decay t → bW. Since W bosons decay to the three lepton generations equally, while
H+ may predominantly decay into τν, charged Higgs bosons can be searched for using the
violation of lepton universality in top quark decays. The analysis in this paper is based on
4.6 fb−1 of proton-proton collision data at √s = 7 TeV collected by the ATLAS experiment
at the Large Hadron Collider. Signatures containing leptons (e or μ) and/or a hadronically
decaying τ (τhad) are used. Event yield ratios between e+τhad and e+μ, as well as between
μ+τhad and μ+e, final states are measured in the data and compared to predictions from
simulations. This ratio-based method reduces the impact of systematic uncertainties in
the analysis. No significant deviation from the Standard Model predictions is observed.
With the assumption that the branching fraction B(H+ → τν) is 100%, upper limits in
the range 3.2%–4.4% can be placed on the branching fraction B(t → bH+) for charged
Higgs boson masses mH+ in the range 90–140GeV. After combination with results from a
search for charged Higgs bosons in t¯t decays using the τhad+jets final state, upper limits
on B(t → bH+) can be set in the range 0.8%–3.4%, for mH+ in the range 90–160GeV