pinecone/core-2020-05-10-deduplication huggingface dataset:
Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.

International audienceCONTEXT: Results of comparative genomic hybridization studies have suggested that rare copy number variations (CNVs) at numerous loci are involved in the cause of mental retardation, autism spectrum disorders, and schizophrenia. OBJECTIVES: To provide an estimate of the collective frequency of a set of recurrent or overlapping CNVs in 3 different groups of cases compared with healthy control subjects and to assess whether each CNV is present in more than 1 clinical category. DESIGN: Case-control study. SETTING: Academic research. PARTICIPANTS: We investigated 28 candidate loci previously identified by comparative genomic hybridization studies for gene dosage alteration in 247 cases with mental retardation, in 260 cases with autism spectrum disorders, in 236 cases with schizophrenia or schizoaffective disorder, and in 236 controls. MAIN OUTCOME MEASURES: Collective and individual frequencies of the analyzed CNVs in cases compared with controls. RESULTS: Recurrent or overlapping CNVs were found in cases at 39.3% of the selected loci. The collective frequency of CNVs at these loci is significantly increased in cases with autism, in cases with schizophrenia, and in cases with mental retardation compared with controls (P < .001, P = .01, and P = .001, respectively, Fisher exact test). Individual significance (P = .02 without correction for multiple testing) was reached for the association between autism and a 350-kilobase deletion located at 22q11 and spanning the PRODH and DGCR6 genes. CONCLUSIONS: Weakly to moderately recurrent CNVs (transmitted or occurring de novo) seem to be causative or contributory factors for these diseases. Most of these CNVs (which contain genes involved in neurotransmission or in synapse formation and maintenance) are present in the 3 pathologic conditions (schizophrenia, autism, and mental retardation), supporting the existence of shared biologic pathways in these neurodevelopmental disorders
Simple and sensitive method for quantification of fludarabine triphosphate intracellular concentration in leukemic cells

A simple, isocratic HPLC method was newly developed for quantitating intracellular fludarabine triphosphate (F-ara-ATP).  Samples (500 µl) were injected onto an anion-exchange column and eluted isocratically with phosphate-acetonitrile buffer (flow rate: 0.7 ml/min) at an ambient temperature.  F-ara-ATP was quantitated according to its peak area at the absorbance of 261 nm.  The standard curve was linear with minimal within-day and inter-day variability.  The low and high quantification limits were 50 pmol and 20 nmol, respectively.  The method was capable of measuring F-ara-ATP generated in cultured leukemic cells in vitro.  Thus, our method will be useful because of its sensitivity and simplicity as well as applicability to biological materials
Cathodoluminescence spectroscopy of ambipolar diffusion in (Al,Ga)As barriers 
and capture of nonequilibrium carriers in GaAs quantum well

Ambipolar vertical diffusion of carriers generated in an Al0.3Ga0.7As barrier is investigated by cathodoluminescence  CL  spectroscopy in a system containing a sequence of GaAs-based quantum wells  QWs . The intensity distribution of the CL line scan exhibits a single exponential decay for the first QW of the sequence, reflecting a pure diffusion-limited transport. However, the CL line scans of the second, third, and fourth QWs are governed by diffusion only for large separations between the electron beam and the corresponding QW. For smaller distances, the CL intensity distribution is significantly influenced by the carrier capture into the intervening QWs
Model interoperability in building information modelling

The exchange of design models in the design and construction industry is evolving away from 2-dimensional computer-aided design (CAD) and paper towards semantically-rich 3-dimensional digital models. This approach, known as Building Information Modelling (BIM), is anticipated to become the primary means of information exchange between the various parties involved in construction projects. From a technical perspective, the domain represents an interesting study in model-based interoperability, since the models are large and complex, and the industry is one in which collaboration is a vital part of business. In this paper, we present our experiences with issues of model-based interoperability in exchanging building information models between various tools, and in implementing tools which consume BIM models, particularly using the industry standard IFC data modelling format. We report on the successes and challenges in these endeavours, as the industry endeavours to move further towards fully digitised information exchange
Globalization, culture, and marketing strategy: Introduction to the special issue

This special issue of the Journal of Business Research features eleven articles selected from the papers presented during the fifth meeting of the Royal Bank International Research Seminar which took place in Montreal at the John Molson School of Business, Concordia University, September 25 and 26, 2009. They cover topics related to globalization, cultural values, global consumer behavior, market segmentation, marketing strategies of emerging economies, consumer socialization, materialism, service quality, and government actions
Solving a robust airline crew pairing problem with column generation

In this study, we solve a robust version of the airline crew pairing problem. Our concept of robustness was partially shaped during our discussions with small local airlines in Turkey which may have to add a set of extra flights into their schedule at short notice during operation. Thus, robustness in this case is related to the ability of accommodating these extra flights at the time of operation by disrupting the original plans as minimally as possible. We focus on the crew pairing aspect of robustness and prescribe that the planned crew pairings incorporate a number of predefined recovery solutions for each potential extra flight. These solutions are implemented only if necessary for recovery purposes and involve either inserting an extra flight into an existing pairing or partially swapping the flights in two existing pairings in order to cover an extra flight. The resulting mathematical programming model follows the conventional set covering formulation of the airline crew pairing problem typically solved by column generation with an additional complication. The model includes constraints that depend on the columns due to the robustness consideration and grows not only column-wise but also row-wise as new columns are generated. To solve this dicult model, we propose a row and column generation approach. This approach requires a set of modifications to the multi-label shortest path problem for pricing out new columns (pairings) and various mechanisms to handle the simultaneous increase in the number of rows and columns in the restricted master problem during column generation. We conduct computational experiments on a set of real instances compiled from a local airline in Turkey
Approximate Analytical Model for the Squeeze-Film Lubrication of the Human Ankle Joint with Synovial Fluid Filtrated by Articular Cartilage

The aim of this article is to propose an analytical approximate squeeze-film lubrication model of the human ankle joint for a quick assessment of the synovial pressure field and the load carrying due to the squeeze motion. The model starts from the theory of boosted lubrication for the human articular joints lubrication (Walker et al., Rheum Dis 27:512–520, 1968; Maroudas, Lubrication and wear in joints. Sector, London, 1969) and takes into account the fluid transport across the articular cartilage using Darcy’s equation to depict the synovial fluid motion through a porous cartilage matrix. The human ankle joint is assumed to be cylindrical enabling motion in the sagittal plane only. The proposed model is based on a modified Reynolds equation; its integration allows to obtain a quick assessment on the synovial pressure field showing a good agreement with those obtained numerically (Hlavacek, J Biomech 33:1415–1422, 2000). The analytical integration allows the closed form description of the synovial fluid film force and the calculation of the unsteady gap thickness
Fusion of children’s speech and 2D gestures when conversing with 3D characters

Most existing multi-modal prototypes enabling users to combine 2D gestures and speech input are task-oriented. They help adult users solve particular information tasks often in 2D standard Graphical User Interfaces. This paper describes the NICE Andersen system, which aims at demonstrating multi-modal conversation between humans and embodied historical and literary characters. The target users are 10–18 years old children and teenagers. We discuss issues in 2D gesture recognition and interpretation as well as temporal and semantic dimensions of input fusion, ranging from systems and component design through technical evaluation and user evaluation with two different user groups. We observed that recognition and understanding of spoken deictics were quite robust and that spoken deictics were always used in multimodal input. We identified the causes of the most frequent failures of input fusion and suggest possible improvements for removing these errors. The concluding discussion summarises the knowledge provided by the NICE Andersen system on
how children gesture and combine their 2D gestures with speech when conversing with a 3D character, and looks at some of the challenges facing theoretical solutions aimed at supporting unconstrained speech/2D gesture fusion
Quantiﬁcation and localization of the liquid zone of partially remelted M2 tool steel using X-ray microtomography and scanning electron microscopy

The authors warmly thank Luc Morhain and Marc Wary (Arts et Métiers ParisTech CER Metz) for their technical support.Thixoforming of steels poses challenges due to the high temperatures involved and the lack of understanding of thermomechanical behavior. The volume fractions of the liquid and solid phases in the semi-solid state are the most important parameters for such a form-ing process, as they aﬀect the viscosity and hence the ﬂow behavior of the material. Two-dimensional observations might not always be suﬃcient, as the size distribution and the connectivity of phases cannot be obtained from associated measurements, which can only be determined by three-dimensional (3-D) investigation. This paper presents the ﬁrst application of high-energy X-ray microtomography to the microstructure of steel in the semi-solid state. The microstructure of M2 high-speed tool steel was studied in both as-received and heated-and-quenched states. From the reconstructed images, 3-D information could be obtained and was compared with scanning elec-tron microscopy and energy dispersive spectrometry observations. The volume fraction and the location of liquid phase in the semi-solid state were determined in particular, and the continuous solid skeleton was investigated
Characterization of metal-resistant plant-growth promoting Bacillus weihenstephanensis isolated from serpentine soil in Portugal

A metal-resistant bacterial strain SM3 isolated from a serpentine soil in the north-east of Portugal was characterized as Bacillus weihenstephanensis based on the morphological and biochemical characteristics and on the comparative analysis of the partial 16S ribosomal DNA sequence. Bacillus weihenstephanensis SM3 showed a high degree of resistance to nickel (1500 mg l-1), copper (500 mg l-1) and zinc (700 mg l-1) and also to antibiotics (ampicillin, penicillin, kanamycin and streptomycin). Strain SM3 has also exhibited the capability of solubilizing phosphate and producing indole-3-acetic acid (IAA) both in the absence and in the presence of metals (Ni, Cu and Zn). A pot experiment was conducted to elucidate the effects of strain SM3 on plant growth and uptake of Ni, Cu or Zn by Helianthus annuus. Inoculation with strain SM3 increased the shoot and root biomass of H. annuus  grown in both non-contaminated and contaminated soil. Furthermore, strain SM3 increased the accumulation of Cu and Zn in the root and shoot systems. A batch experiment was also conducted to assess the metal mobilization potential of strain SM3 in soil. Inoculation with this strain increased the concentrations of water soluble Ni, Cu and Zn in soil. Metal solubilization by this bacterial strain may be an important process to promote the uptake of heavy metals by plants. This study elucidates the multifarious role of strain SM3 in plant growth promotion and its metal mobilizing potential. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)http://dx.doi.org/10.1002/jobm.20080007
Voltammetric Oxidation of Drugs of Abuse II. Codeine and Metabolites

The oxidation of codeine on glassy carbon electrodes has been studied in detail using differential pulse voltammetry. The results obtained using a glassy carbon electrode clearly show a much more complex oxidation mechanism than that previously reported when platinum and gold electrodes were used. To clarify the codeine oxidative profile, several metabolites and analogues of this alkaloid, codeine N-oxide, norcodeine, dihydrocodeine, acetylcodeine and 6-chlorodesoxycodeine, were synthesized and studied. It was deduced that the anodic waves observed in codeine oxidation are related to the presence of methoxy, hydroxy and tertiary amine groups. Due to the similarity of potentials at which these oxidative processes take place, at some pHs an overlap of peaks occurs and only one anodic wave is observed.http://dx.doi.org/10.1002/elan.20030296
Exchanged identities in a complex multiple homicide case. Identification and cause of death

Abstract  We report a multiple homicide in Angola involving six Portuguese citizens. Immediately after the crime, four bodies were retrieved from the homicide site. Forensic autopsies were allegedly performed by local doctors and three bodies were transferred to Portugal, where they were buried with no extra expertise, presumably identified only by the examinations carried out in Angola. The two remaining bodies, presumably from sub-adults, were only discovered 1 year later. At that time, some bone samples of these two corpses were sent to Portugal. A multidisciplinary team of the National Institute of Legal Medicine (NILM) in Portugal, including forensic anthropologist and pathologists, and forensic geneticist, found out that the bodies were previously misidentified. In fact, the anthropological and genetic examinations on the remains of the two persons showed that they did not belong to a child and an adolescent but instead to two adult victims, at least one of them was supposed to be buried in Portugal since 1 year. The verification of this misunderstanding led to a series of exhumations, of the three victims previously buried in Portugal. In all, the identities were reconstructed and the cause of death could be established in four of them. A multiplicity of severe traumatic cranial injuries were detected, which were, undoubtedly due to a violent death.http://dx.doi.org/10.1007/s00414-007-0195-
A memetic algorithm for multi-objective dynamic location problems

Abstract  This paper describes a new multiobjective interactive memetic algorithm applied to dynamic location problems. The memetic algorithm integrates genetic procedures and local search. It is able to solve capacitated and uncapacitated multi-objective single or multi-level dynamic location problems. These problems are characterized by explicitly considering the possibility of a facility being open, closed and reopen more than once during the planning horizon. It is possible to distinguish the opening and reopening periods, assigning them different coefficient values in the objective functions. The algorithm is part of an interactive procedure that asks the decision maker to define interesting search areas by establishing limits to the objective function values or by indicating reference points. The procedure will be applied to some illustrative location problems.http://dx.doi.org/10.1007/s10898-007-9239-
Equilibrium Shapes of Non-axisymmetric Liquid Bridges of Arbitrary Volume in Gravitational Fields and their Potential Energy

Bifurcation diagrams of nonaxisymmetric liquid bridges subject to a lateral gravitational force and to both lateral and axial gravitational forces are found by solving the Young–Laplace equation for the interface by a finite difference method. The potential energy of the equilibrium shapes is also calculated. The results obtained show that the slenderness of the bridge determines whether the breaking of the liquid bridge subject to a lateral gravitational force leads to equal or unequal drops. The stability limits calculated are compared with the ones obtained using asymptotic techniques around the cylinder, the agreement being extremely good for a wide range of the parameters
An NMR study on internal browning in pears

Internal browning in pears (Pyrus communis L. cv. Blanquilla) has been studied by NMR and MRI in order to develop a non-destructive procedure for on-line disorder identification. For NMR relaxometry, disordered tissue shows higher transverse relaxation rates compared to sound tissue, especially at higher magnetic field strength and for long pulse spacing. Membrane alteration and therefore tissue disintegration, as well as water evaporation, appear to be the main causes of this response. Correlation between relaxation times and diffusion showed that the proton pools in disordered tissue are grouped into a smaller number of populations compared to sound tissue, also highlighting cell decompartmentation in disordered tissue. At a macroscopic level, fast low angle shot MR images, effective transverse relaxation-weighted (TR 11 ms and TE 3.7 ms) and proton density-weighted (TR 7.6 ms and TE 2.5 ms), were acquired for pears at a rate of 54 mm/s. Images have been discriminated for internal breakdown according to histogram characteristics. Up to 94 and 96% of pears, respectively, were correctly classified in the former and the latter type of images. In this study a minimum value of 12% of tissue affected by breakdown was always clearly identifie
Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

It is still an open question whether subjective memory complaints (SMC) can actually be considered to be clinically relevant predictors for the development of an objective memory impairment and even dementia. There is growing evidence that suggests that SMC are associated with an increased risk of dementia and with the presence of biological correlates of early Alzheimer's disease. In this paper, in order to shed some light on this issue, we try to discern whether subjects with SMC showed a different profile of functional connectivity compared with subjects with mild cognitive impairment (MCI) and healthy elderly subjects. In the present study, we compare the degree of synchronization of brain signals recorded with magnetoencephalography between three groups of subjects (56 in total): 19 with MCI, 12 with SMC and 25 healthy controls during a memory task. Synchronization likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. Briefly, results show that subjects with SMC have a very similar pattern of connectivity to control group, but on average, they present a lower synchronization value. These results could indicate that SMC are representing an initial stage with a hypo-synchronization (in comparison with the control group) where the brain system is still not compensating for the failing memory networks, but behaving as controls when compared with the MCI subjects
Extruded flour improves batter pick-up, coating crispness and aroma profile

Fried battered foods are widely consumed worldwide. In this study, the influence of the replacement of native wheat flour by extruded flours (7.5 and 15%) subjected to different extrusion severities on chicken nuggets was assessed. Microstructure, pick-up, moisture and fat content, texture, colour, volatile profile, and consumer acceptability were evaluated. Extruded flour replacement resulted in batters with improved pick-up with increasing percentage and severity of extrusion treatment. Extruded flour also contributed to a moisture increase, while oil remained practically unchanged. Textural properties highlighted a higher crispness of batters made with high-severity treatment extruded flours. Volatile compounds analyses revealed lower amount of lipid oxidation (lower rancidity notes) and higher furfuryl alcohol content (pleasant aroma and darker crust) in fried batters containing extruded flour. Consumers testing showed that batters made with intermediate-severity treatment extruded flour presented the best acceptability. These results confirm that extruded flour inclusion improves the quality of deep-fried batters
Probabilistic opinion pooling generalised. Part two: the premise-based approach

How can several individuals’ probability functions on a given σ-algebra of events be aggregated into a collective probability function? Classic approaches to this problem usually require ‘event-wise independence’: the collective probability for each event should depend only on the individuals’ probabilities for that event. In practice, however, some events may be ‘basic’ and others ‘derivative’, so that it makes sense first to aggregate the probabilities for the former and then to let these constrain the probabilities for the latter. We formalize this idea by introducing a ‘premise-based’ approach to probabilistic opinion pooling, and show that, under a variety of assumptions, it leads to linear or neutral opinion pooling on the ‘premises’
Room temperature photoluminescence from nanostructured amorphous carbon

Visible room-temperature photoluminescence (PL) was observed from hydrogen-free nanostructured amorphous carbon films deposited by pulsed laser ablation in different background pressures of argon (PAr). By varying PAr from 5 to 340 mTorr, the film morphology changed from smooth to rough and at the highest pressures, low-density filamentary growth was observed. Over the same pressure regime an increase in the ordering of s p2 bonded C content was observed using visible Raman spectroscopy. The origin of the PL is discussed in terms of improved carrier localization within an increased s p2 rich phase. © 2004 American Institute of Physics
Regulation of the Ecto-Nucleotidase Pathway in Rat Hippocampal Nerve Terminals

Ecto-nucleotidases play a pivotal role in terminating the signalling via ATP and in producing adenosine, a neuromodulator in the nervous system. We have now investigated the pattern of adenosine formation with different concentrations of extracellular ATP in rat hippocampal nerve terminals. It was found that adenosine formation is delayed with increasing concentrations of ATP. Also, the rate of adenosine formation increased sharply when the extracellular concentrations of ATP + ADP decrease below 5 µM, indicating that ATP/ADP feed-forwardly inhibit ecto-5'-nucleotidase allowing a burst-like formation of adenosine possibly designed to activate facilitatory A2A receptors. Initial rate measurements of ecto-5'-nucleotidase in hippocampal nerve terminals, using IMP as substrate, showed that ATP and ADP are competitive inhibitors (apparent Ki of 14 and 4 µM). In contrast, in hippocampal immunopurified cholinergic nerve terminals, a burst-like formation of adenosine is not apparent, suggesting that channelling processes may overcome the feed-forward inhibition of ecto-5'-nucleotidase, thus favouring A1 receptor activation.http://dx.doi.org/10.1023/A:101239271960