pinecone/core-2020-05-10-deduplication huggingface dataset:
A coordinated X-ray and Optical Campaign of the Nearest Massive
  Eclipsing Binary, $\delta$ Orionis Aa: IV. A multiwavelength, non-LTE
  spectroscopic analysis

Eclipsing systems of massive stars allow one to explore the properties of
their components in great detail. We perform a multi-wavelength, non-LTE
analysis of the three components of the massive multiple system $\delta$ Ori A,
focusing on the fundamental stellar properties, stellar winds, and X-ray
characteristics of the system. The primary's distance-independent parameters
turn out to be characteristic for its spectral type (O9.5 II), but usage of the
${\rm \it Hipparcos}$ parallax yields surprisingly low values for the mass,
radius, and luminosity. Consistent values follow only if $\delta$ Ori lies at
about twice the ${\rm \it Hipparcos}$ distance, in the vicinity of the
$\sigma$-Orionis cluster. The primary and tertiary dominate the spectrum and
leave the secondary only marginally detectable. We estimate the V-band
magnitude difference between primary and secondary to be $\Delta V \approx
2.\!\!^{\rm m}8$. The inferred parameters suggest the secondary is an early
B-type dwarf ($\approx$ B1 V), while the tertiary is an early B-type subgiant
($\approx$ B0 IV). We find evidence for rapid turbulent velocities ($\sim 200$
km ${\rm s}^{-1}$) and wind inhomogeneities, partially optically thick, in the
primary's wind. The bulk of the X-ray emission likely emerges from the
primary's stellar wind ($\log L_{\text{X}} / L_{\text{Bol}} \approx -6.85$),
initiating close to the stellar surface at $R_0 \sim 1.1\,R_*$. Accounting for
clumping, the mass-loss rate of the primary is found to be $\log \dot{M}
\approx -6.4\,[M_\odot\,{\rm yr}^{-1}]$, which agrees with hydrodynamic
predictions, and provides a consistent picture along the X-ray, UV, optical and
radio spectral domains.Comment: Accepted for Publication in APJ, 21 pages, 16 figures and 2 table
Observation of the ${B^0 \to \rho^0 \rho^0}$ decay from an amplitude
  analysis of ${B^0 \to (\pi^+\pi^-)(\pi^+\pi^-)}$ decays

Proton-proton collision data recorded in 2011 and 2012 by the \lhcb
experiment, co\-rres\-pon\-ding to an integrated luminosity of 3.0\invfb, are
a\-na\-lysed to search for the charmless ${B^0 \to \rho^0 \rho^0}$ decay. More
than 600 ${\B^0 \to (\pi^+\pi^-)(\pi^+\pi^-)}$ signal decays are selected and
used to perform an amplitude analysis from which the ${B^0 \to \rho^0 \rho^0}$
decay is observed for the first time with 7.1 standard deviations significance.
The fraction of ${B^0 \to \rho^0 \rho^0}$ decays yielding a longitudinally
polarised final state is measured to be $\fL = 0.745^{+0.048}_{-0.058} ({\rm
stat}) \pm 0.034 ({\rm syst})$. The ${B^0 \to \rho^0 \rho^0}$ branching
fraction, using the ${\B^0 \to \phi K^*(892)^{0}}$ decay as reference, is also
reported as ${\BF(B^0 \to \rho^0 \rho^0) = (0.94 \pm 0.17 ({\rm stat}) \pm 0.09
({\rm syst}) \pm 0.06 ({\rm BF})) \times 10^{-6}}$.Comment: as published in PL
Asymptotic safety in $O(N)$ scalar models coupled to gravity

We extend recent results on scalar-tensor theories to the case of an
O(N)-invariant multiplet. Some exact fixed point solutions of the RG flow
equations are discussed. We find that also in the functional context, on
employing a standard "type-I" cutoff, too many scalars destroy the
gravitational fixed point. For d=3 we show the existence of the gravitationally
dressed Wilson-Fisher fixed point also for N>1. We discuss also the results of
the analysis for a different, scalar-free, coarse-graining scheme.Comment: Latex, 15 pages, 1 figur
Wideband superconducting nanotube electrometer

We have investigated the microwave response of nanotube Josephson junctions
at 600-900 MHz at microwave powers corresponding to currents from 0 to $2\times
I_{\mathrm C}$ in the junction. Compared with theoretical modeling, the
response of the junctions correspond well to the lumped element model of
resistively and capacitively shunted junction. We demonstrate the operation of
these superconducting FETs as charge detectors at high frequencies without any
matching circuits. Gate-voltage-induced charge $Q_{\rm G}$ modifies the
critical current $I_{\rm C}$, which changes the effective impedance of the
junction under microwave irradiation. This change, dependent on the transfer
characteristics $dI_{\mathrm C}/dQ_{\rm G}$, modifies the reflected signal and
it can be used for wide band electrometry. We measure a sensitivity of
$3.1\times10^{-5}$ $e/\sqrt{\mathrm{Hz}}$ from a sample which has a maximum
switching current of 2.6 nA.Comment: 4 pages, 4 figure
Harmonizing and supporting infection control training in Europe.

Healthcare-associated infection (HCAI), patient safety, and the harmonization of related policies and programmes are the focus of increasing attention and activity in Europe. Infection control training for healthcare workers (HCWs) is a cornerstone of all patient safety and HCAI prevention and control programmes. In 2009 the European Centre for Disease Prevention and Control (ECDC) commissioned an assessment of needs for training in infection control in Europe (TRICE), which showed a substantial increase in commitment to HCAI prevention. On the other hand, it also identified obstacles to the harmonization and promotion of training in infection control and hospital hygiene (IC/HH), mostly due to differences between countries in: (i) the required qualifications of HCWs, particularly nurses; (ii) the available resources; and (iii) the sustainability of IC/HH programmes. In 2013, ECDC published core competencies for infection control and hospital hygiene professionals in the European Union and a new project was launched ['Implementation of a training strategy for infection control in the European Union' (TRICE-IS)] that aimed to: define an agreed methodology and standards for the evaluation of IC/HH courses and training programmes; develop a flexible IC/HH taxonomy; and implement an easily accessible web tool in 'Wiki' format for IC/HH professionals. This paper reviews several aspects of the TRICE and the TRICE-IS projects
Search for signatures of magnetically-induced alignment in the arrival directions measured by the Pierre Auger Observatory

We present the results of an analysis of data recorded at the Pierre Auger Observatory in which we search for groups of directionally-aligned events (or ‘multiplets’) which exhibit a correlation between arrival direction and the inverse of the energy. These signatures are expected from sets of events coming from the same source after having been deflected by intervening coherent magnetic fields. The observation of several events from the same source would open the possibility to accurately reconstruct the position of the source and also measure the integral of the component of the magnetic field orthogonal to the trajectory of the cosmic rays. We describe the largest multiplets found and compute the probability that they appeared by chance from an isotropic distribution. We find no statistically significant evidence for the presence of multiplets arising from magnetic deflections in the present data
Advanced functionality for radio analysis in the Offline software framework of the Pierre Auger Observatory

The advent of the Auger Engineering Radio Array (AERA) necessitates the development of a powerful framework for the analysis of radio measurements of cosmic ray air showers. As AERA performs “radio-hybrid” measurements of air shower radio emission in coincidence with the surface particle detectors and fluorescence telescopes of the Pierre Auger Observatory, the radio analysis functionality had to be incorporated in the existing hybrid analysis solutions for fluorescence and surface detector data. This goal has been achieved in a natural way by extending the existing Auger Offline software framework with radio functionality. In this article, we lay out the design, highlights and features of the radio extension implemented in the Auger Offline framework. Its functionality has achieved a high degree of sophistication and offers advanced features such as vectorial reconstruction of the electric field, advanced signal processing algorithms, a transparent and efficient handling of FFTs, a very detailed simulation of detector effects, and the read-in of multiple data formats including data from various radio simulation codes. The source code of this radio functionality can be made available to interested parties on request
Comparison of the Z/γ ∗ + jets to γ + jets cross sections in pp collisions at s√=8TeV

A comparison of the differential cross sections for the processes Z/γ* + jets and photon (γ)+jets is presented. The measurements are based on data collected with the CMS detector at s=8(Formula presented.) TeV corresponding to an integrated luminosity of 19.7 fb−1. The differential cross sections and their ratios are presented as functions of pT. The measurements are also shown as functions of the jet multiplicity. Differential cross sections are obtained as functions of the ratio of the Z/γ*pT to the sum of all jet transverse momenta and of the ratio of the Z/γ*pT to the leading jet transverse momentum. The data are corrected for detector effects and are compared to simulations based on several QCD calculation
Biomarker discovery in asthma and COPD: Application of proteomics techniques in human and mice – mini review

The use of advanced proteomics approaches in the search for biomarkers in chronic lung diseases, such as asthma and COPD, is rather limited. Asthma and COPD are complex disorders, which can be subdivided into several phenotypes. This results in a heterogeneity of differential expressed biological molecules. Furthermore, genetic differences between animals and humans make ‘translation’ of possible biomarkers challenging. Yet, the improved sensitivity and high throughput of proteomic techniques could be an important asset for(new) protein biomarker discovery in either human or animal models. We have reviewed the literature that reported the use of different proteomics approaches performed on samples obtained from humans and murine models in asthma and COPD research for the discovery of new biomarkers of diseases, biomarkers of sensitization or for the refinement of treatment. There is an increasing trend in the use of proteomics to explore new biomarkers of asthma or COPD. Although several murine models have been developed to study these lung diseases, and proteomics studies have been performed, ‘translation’ of identified candidate biomarkers into clinical studies is often lacking.status: publishe
Low voltage I–V characteristics in magnetic tunneling junctions

3 pages, 2 figures.We show that elastic currents, which take into account variations of the tunneling transmission with voltage and a large ratio of majority to minority spin densities of states of the conduction band at the Fermi level, can account for the low voltage current anomalies observed in magnet–oxide–magnet junctions.This work was supported by EU Project No. IST-2000-\ud
26011. One of the authors is grateful to the LFSPN for support. He also acknowledges partial financial support\ud
from Fundaçao de Amparo à Pesquisa do Estado de Sao\ud
Paulo (Brazil) through project No. FAPESP 2000/09434-3.Peer reviewe
A expressão do antígeno humano leucocitário G (HLA-G) em pacientes com polipose nasossinusal

INTRODUCTION:Sinonasal polyposis (NP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown. HLA-G molecules are a kind of no classic class I antigen with anti-inflammatory and tolerogenic properties. Little attention has been paid to the role of HLA-G chronic inflammatory disorders.OBJECTIVE:The aim of this study is to investigate the expression of HLA-G in the NP.MATERIALS AND METHODS:Prospective study involving samples of patients presenting with nasal polyposis that were subjected to the immunohistochemistry technique. After a skin prick test, all patients were divided into atopic and nonatopic groups and classified as asthmatic or non-asthmatic.RESULTS:Immunohistochemical staining demonstrated a higher expression of the HLA-G molecule in samples from nonatopic than in those from atopic patients, and was significantly lower in the non-asthmatic patients.CONCLUSION:These results indicate that HLA-G may play an important role in the pathology of nasal polyposis. Considering the anti-inflammatory properties of HLA-G, this study suggests that it could reduce susceptibility to atopy and asthma.INTRODUÇÃO:Polipose nasossinusal (PNS) é uma patologia inflamatória crônica das cavidades nasais/paranasais que afeta 1%-4% da população. Embora os pólipos pareçam ser uma manifestação de inflamação crônica em ambos os indivíduos alérgicos e não alérgicos, a patogênese da polipose nasal permanece desconhecida. Moléculas HLA-G são antígenos não clássicos da classe I com propriedades anti-inflamatórias e tolerogênicas. Pouca atenção tem sido dada ao papel do HLA-G em doenças inflamatórias crônicas.OBJETIVO:Investigar a expressão de HLA-G na PNS.MATERIAIS E MÉTODOS:Estudo prospectivo de pacientes com polipose nasal que foram submetidas à técnica de imuno-histoquímica. Após realizarem teste cutâneo, os pacientes foram divididos em grupos atópicos e não atópicos e classificados como asmáticos ou não asmáticos.RESULTADO:A coloração imuno-histoquímica mostrou uma maior expressão da molécula HLA-G em pacientes não atópicos do que naqueles atópicos e foi significativamente inferior nos pacientes não asmáticos.CONCLUSÃO:Os resultados indicam que o HLA-G pode ter um papel importante na patologia da polipose nasal. Considerando as propriedades anti-inflamatórias do HLA-G, este estudo sugere que ele poderia reduzir a susceptibilidade a atopia e asma.Universidade Federal de GoiásUniversidade Estadual de GoiásPontifícia Universidade Católica de GoiásUniversidade Federal de São Paulo (UNIFESP)UNIFESPSciEL
CD24 + Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation

Tumor-initiating cells (T-ICs) are a subpopulation of chemoresistant tumor cells that have been shown to cause tumor recurrence upon chemotherapy. Identification of T-ICs and their related pathways are therefore priorities for the development of new therapeutic paradigms. We established chemoresistant hepatocellular carcinoma (HCC) xenograft tumors in immunocompromised mice in which an enriched T-IC population was capable of tumor initiation and self-renewal. With this model, we found CD24 to be upregulated in residual chemoresistant tumors when compared with bulk tumor upon cisplatin treatment. CD24 + HCC cells were found to be critical for the maintenance, self-renewal, differentiation, and metastasis of tumors and to significantly impact patients' clinical outcome. With a lentiviral-based knockdown approach, CD24 was found to be a functional liver T-IC marker that drives T-IC genesis through STAT3-mediated NANOG regulation. Our findings point to a CD24 cascade in liver T-ICs that may provide an attractive therapeutic target for HCC patients. © 2011 Elsevier Inc.postprin
Time Varying Parameter and Fixed Parameter Linear AIDS: An Application to Tourism Demand Forecasting

This study develops time varying parameter (TVP) linear almost ideal demand system (LAIDS) models in both long-run (LR) static and short-run error correction (EC) forms. The superiority of TVP-LAIDS models over the original static version and the fixed-parameter EC counterparts is examined in an empirical study of modelling and forecasting the demand for tourism in Western European destinations by UK residents. Both the long-run static and the short-run EC-LAIDS models are estimated using the Kalman filter algorithm. The evolution of demand elasticities over time is illustrated using the Kalman filter estimation results. The remarkably improved forecasting performance of the TVP-LAIDS relative to the fixed-parameter LAIDS is illustrated by a one-year- to four-years-ahead forecasting performance assessment. Both the unrestricted TVP-LR-LAIDS and TVP-EC-LAIDS outperform their fixed-parameter counterparts in the overall evaluation of demand level forecasts, and the TVP-EC-LAIDS is also ranked ahead of most other competitors when demand changes are concerned. (c) 2005 International Institute of Forecasters. Published by Elsevier B.V. All rights reserved
High precision locations of long-period events at La Fossa Crater  (Vulcano Island, Italy)

Since the last eruption in 1888-90, the volcanic activity on Vulcano Island (Aeolian Archipelago, Italy) has been limited to fumarolic degassing. Fumaroles are mainly concentred at the active cone of La Fossa in the northern sector of the island and are periodically characterized by increases in the temperature as well as in the amount of both CO2 and He .Seismic background activity at Vulcano is dominated by micro-seismicity originating at shallow depth (<1-1.5 km) under La Fossa cone. This seismicity is related to geothermal system processes and comprises long period (LP) events. LPs are generally considered as the resonance of a fluid-filled volume in response to a trigger. We analyzed LP events recorded during an anomalous degassing period (August-October 2006) applying a high precision technique to define the shape of the trigger source. Absolute and high precision locations suggest that LP events recorded at Vulcano, during 2006, were produced by a shallow focal zone ca. 200 m long, 40 m wide and N30-40E oriented. Their occurrence is linked to magmatic fluid inputs that by modifying the hydrothermal system cause excitation of a fluid-filled cavity
The IDIPOS project: is a multidisciplinary data infrastructure for weather and space weather feasible?

The Italian National Antarctic Programme (PNRA) has long supported scientific and technological activities addressed to the implementation, upgrade and maintenance of infrastructure and instruments supporting
geosciences and physical sciences in the polar region. This report describes
the first results of the Italian Database Infrastructure for Polar Observation
Sciences (IDIPOS) project, which was recently approved by the PNRA. The project aims to study the feasibility of the hardware and software infrastructure for the construction of relational databases of acquisitions from past and current experiments in the polar areas. The study
is based on the fundamental characteristics of the infrastructure: its implementation
in Italy, with locations across the country, and its integration into the existing and future telematics infrastructure that will be
available at the Italian bases. The project proposes a modern and hightech infrastructure dedicated to data treatment, accessibility and archiving, in line with international standards. This infrastructure will allow modern, rapid and reliable treatment of the acquired data. The IDIPOS
infrastructure is crucial during the planning phase of scientific and monitoring
activities of the PNRA, especially of those included in the Scientific Committe for Antarctic Research (SCAR) projects, the International Polar Year, and the framework of international cooperation. In the first
phase of the project, the observations are related to research projects in different
PNRA sectors. The infrastructure will be potentially extendable to other observational activities. In this report, the infrastructure is introduced,
while highlighting its usefulness for weather and space-weather forecasting for the scientific community and in the framework of Global Navigation Satellite System (GNSS) Research and Application for Polar Environment (GRAPE) in particular
Looking ahead: Anticipatory cueing of attention to objects others will look at

Seeing a face gaze at an object elicits rapid attention shifts towards the same object. We tested whether gaze cuing is predictive: do people shift their attention towards objects others are merely expected to look at? Participants categorized objects while a face either looked at this object, at another object, or straight ahead. Unbeknownst to participants, one face would only look at drinks and the other at foods. We tested whether attention was drawn towards objects “favoured” by a face even when currently looking straight ahead. Indeed, while gaze expectations initially had a disruptive effect, participants did shift attention to the faces‟ favoured objects once learning had been established, as long as emotional expressions had indicated personal relevance of the object to the individual. These data support predictive models of social perception, which assume that predictions can drive perception and action, as if these stimuli were directly perceived
Learning climate and workplace learning: Does work restructuring make a difference?

In the current study, we propose that organizational learning climate in terms of facilitation learning climate, appreciation learning climate, and error-avoidance climate has the capacity to enhance employees’ level of newly acquired competences. Additionally, we investigated whether this relationship holds when employees face work-restructuring. Structural Equation Modeling was used to test the hypotheses on a large sample of the Dutch working population (N = 1013). The results showed that work restructuring moderated the hypothesized relationships. Under conditions of high restructuring, facilitation learning climate was an important predictor of learning outcomes; yet, under conditions of low work restructuring, appreciation learning climate was more effective. The current paper contributes to research on organizational change and workplace learning by providing evidence that organizational change can impact the way organizational learning climate supports employee learning
D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells.

BACKGROUND: The D prostanoid receptor 2 (DP2; also known as chemoattractant receptor-homologous molecule expressed on TH2 cells) is implicated in the pathogenesis of asthma, but its expression within bronchial biopsy specimens is unknown. OBJECTIVES: We sought to investigate the bronchial submucosal DP2 expression in asthmatic patients and healthy control subjects and to explore its functional role in epithelial cells. METHODS: DP2 protein expression was assessed in bronchial biopsy specimens from asthmatic patients (n = 22) and healthy control subjects (n = 10) by using immunohistochemistry and in primary epithelial cells by using flow cytometry, immunofluorescence, and quantitative RT-PCR. The effects of the selective DP2 agonist 13, 14-dihydro-15-keto prostaglandin D2 on epithelial cell migration and differentiation were determined. RESULTS: Numbers of submucosal DP2(+) cells were increased in asthmatic patients compared with those in healthy control subjects (mean [SEM]: 78 [5] vs 22 [3]/mm(2) submucosa, P < .001). The bronchial epithelium expressed DP2, but its expression was decreased in asthmatic patients compared with that seen in healthy control subjects (mean [SEM]: 21 [3] vs 72 [11]/10 mm(2) epithelial area, P = .001), with similar differences observed in vitro by primary epithelial cells. Squamous metaplasia of the bronchial epithelium was increased in asthmatic patients and related to decreased DP2 expression (rs = 0.69, P < .001). 13, 14-Dihydro-15-keto prostaglandin D2 promoted epithelial cell migration and at air-liquid interface cultures increased the number of MUC5AC(+) and involucrin-positive cells, which were blocked with the DP2-selective antagonist AZD6430. CONCLUSIONS: DP2 is expressed by the bronchial epithelium, and its activation drives epithelial differentiation, suggesting that in addition to its well-characterized role in inflammatory cell migration, DP2 might contribute to airway remodeling in asthmatic patients.Peer-reviewedPublisher Versio