pinecone/core-2020-05-10-deduplication huggingface dataset:
Increasing loyalty to breastfeeding : investigating a product development strategy

This paper demonstrates how social marketing insights were used to influence women’s loyalty to breastfeeding. The paper reports on a social marketing campaign undertaken by the Australian Breastfeeding Association and a government health department, which used a product development strategy in order to increase breastfeeding loyalty. Seeking new approaches to support breastfeeding behaviors is critical and timely, because while initiation rates of breastfeeding are high in developed countries such as the UK, Australia, Canada, and the USA, duration rates are significantly lower. Results indicate that a product focused strategy influences pregnant women’s loyalty to exclusively breastfeeding
p63 transcription factor regulates nuclear shape and expression of nuclear envelope-associated genes in epidermal keratinocytes.

The maintenance of a proper nuclear architecture and 3D organization of the genes, enhancer elements and transcription machinery plays an essential role in tissue development and regeneration. Here we show that in the developing skin, epidermal progenitor cells of mice lacking p63 transcription factor display alterations in the nuclear shape accompanied by marked decrease in expression of several nuclear envelop-associated components (Lamin B1, Lamin A/C, SUN1, Nesprin-3, Plectin) compared to controls. Furthermore, ChIP-qPCR assay showed enrichment of p63 on Sun1, Syne3 and Plec promoters, suggesting them as p63 targets. Alterations in the nuclei shape and expression of nuclear envelope-associated proteins were accompanied by altered distribution patterns of the repressive histone marks H3K27me3, H3K9me3 and heterochromatin protein 1- alpha in p63-null keratinocytes. These changes were also accompanied by downregulation of the transcriptional activity and relocation of the keratinocyte-specific gene loci away from the sites of active transcription towards the heterochromatin-enriched repressive nuclear compartments in p63-null cells. These data demonstrate functional links between the nuclear envelope organization, chromatin architecture and gene expression in keratinocytes and suggest nuclear envelope-associated genes as important targets mediating p63-regulated gene expression programme in the epidermis
Incorporation of Drosophila CID/CENP-A and CENP-C into centromeres during early embryonic anaphase.

The centromere/kinetochore complex is indispensable for accurate segregation of chromosomes during cell divisions when it serves as the attachment site for spindle microtubules. Centromere identity in metazoans is believed to be governed by epigenetic mechanisms, because the highly repetitive centromeric DNA is neither sufficient nor required for specifying the assembly site of the kinetochore. A candidate for an epigenetic mark is the centromere-specific histone H3 variant CENP-A that replaces H3 in alternating blocks of chromatin exclusively in active centromeres. CENP-A acts as an initiator of kinetochore assembly, but the detailed dynamics of the deposition of metazoan CENP-A and of other constitutive kinetochore components are largely unknown. Here we show by quantitative fluorescence measurements in living early embryos that functional fluorescent fusion proteins of the Drosophila CENP-A and CENP-C homologs are rapidly incorporated into centromeres during anaphase. This incorporation is independent of ongoing DNA synthesis and pulling forces generated by the mitotic spindle, but strictly coupled to mitotic progression. Thus, our findings uncover a strikingly dynamic behavior of centromere components in anaphase
Combined measurement and QCD analysis of the inclusive e ± p scattering cross sections at HERA

A combination is presented of the inclusive deep inelastic cross sections measured by the H1 and ZEUS Collaborations in neutral and charged current unpolarised e ± p scattering at HERA during the period 1994-2000. The data span six orders of magnitude in negative four-momentum-transfer squared, Q 2, and in Bjorken x. The combination method used takes the correlations of systematic uncertainties into account, resulting in an improved accuracy. The combined data are the sole input in a NLO QCD analysis which determines a new set of parton distributions, HERAPDF1.0, with small experimental uncertainties. This set includes an estimate of the model and parametrisation uncertainties of the fit result
Monetary and fiscal policy interactions with central bank transparency and public investment

In this paper, we study how the interactions between central bank transparency and fiscal policy affect macroeconomic performance and volatility, in a framework where productivity-enhancing public investment could improve future growth potential. We analyze the effects of central bank’s opacity (lack of transparency) according to the marginal effect of public investment by considering the Stackelberg equilibrium where the government is the first mover and the central bank the follower. We show that the optimal choice of tax rate and public investment, when the public investment is highly productivity-enhancing, eliminates the effects of distortionary taxation and fully counterbalance both the direct and the fiscal-disciplining effects of opacity, on the level and variability of inflation and output gap. In the case where the public investment is not sufficiently productivity-enhancing, opacity could still have some disciplining effects as in the benchmark model, which ignores the effects of public investment.
A framework of coopetitive games:applications to the Greek crisis

In the present work we propose an original analytical model of coopetitive game. We shall apply this analytical model of coopetition (based on normal form game theory) to the
Greek crisis, while conceiving this game theory model at a macro level. We construct two realizations of such model, trying to represent possible realistic macro-economic scenarios of the Germany-Greek strategic interaction. We shall suggest - after a deep and complete study of the two samples - feasible transferable utility solutions in a properly coopetitive perspective for the divergent interests which drive the economic policies in the euro area.
Permanent Effects of Economic Crises on Household Welfare: Evidence and Projections from Argentina’s Downturns

The quantification of the impact of crises on household welfare and socioeconomic outcomes is a fundamental input for the design of ex ante safety nets and ex post alleviation programs. Economic downturns have direct effects through employment and household income, but whether these and other impacts are permanent rather than transitory is harder to establish. This study of Argentina estimates the relationship between GDP growth and severe crises on poverty, youth unemployment, and a series of human capital related outcomes, such as infant and maternal health, and school enrollment and progression. The identification strategy relies on provincial variation in GDP, and on a difference in differences estimation from the severe 1999-2002 crisis. The objective is twofold. On the one hand, the study documents the effects of past episodes. On the other hand, it extrapolates past results to provide bounds for the impact of the 2007-2009 financial crisis in Argentina. Besides the expected and well-documented relationship between crises and poverty levels, the main finding of this study is a strong effect on infant mortality and low weight at birth. Moreover, there is an asymmetry in these effects: the negative impact of downturns is greater than the positive evolution during recoveries. The results for education variables are more ambiguous, and even counter-cyclical in some cases. The document discusses the implications of these estimates for the current episode. Overall, these results provide evidence of permanent effects of economic crises through lower levels of human capital, worsening health outcomes and increased mortality.
Carbon cage-like materials as potential low work function metallic compounds : Case of clathrates

We present an ab initio calculation of the electronic affinity of the hypothetical C-46 clathrate by studying its bare and hydrogenated (100) surfaces. We show that such a system shares with the diamond phase a small electronic affinity. Furthermore, contrary to the diamond phase, the possibility of endohedrally doping these cage-like systems allows to significantly raise the position of the Fermi level, resulting in a true metal with a small work function. This is illustrated in the case of the Li-8 @ C-46 doped compound. Such a class of materials might be of much interest for the design of electron-emitting devices. (C) 2002 American Institute of Physics
Endogenous Systemic Liquidity Risk

Traditionally, aggregate liquidity shocks are modelled as exogenous events. Extending our previous work (Cao & Illing, 2007), this paper analyses the adequate policy response to endogenous systemic liquidity risk. We analyse the feedback between lender of last resort policy and incentives of private banks, determining the aggregate amount of liquidity available. We show that imposing minimum liquidity standards for banks ex ante are a crucial requirement for sensible lender of last resort policy. In addition, we analyse the impact of equity requirements and narrow banking, in the sense that banks are required to hold sufficient liquid funds so as to pay out in all contingencies. We show that such a policy is strictly inferior to imposing minimum liquidity standards ex ante combined with lender of last resort policy.
Quantitative simulation of a magneto-optical trap operating near the photon recoil limit.

We present a quantitative model for magneto-optical traps operating on narrow transitions, where the transition linewidth and the recoil shift are comparable. We combine a quantum treatment of the light scattering process with a Monte-Carlo simulation of the atomic motion. By comparing our model to an experiment operating on the 5s21S0→5s5p3P15s21S0→5s5p3P1 transition in strontium, we show that it quantitatively reproduces the cloud size, position, temperature and dynamics over a wide range of operating conditions, without any adjustable parameters. We also present an extension of the model that quantitatively reproduces the transfer of atoms into a far off-resonance dipole trap, highlighting its use as a tool for optimizing complex cold atom experiments
A-Wardpβ: effective hierarchical clustering using the Minkowski metric and a fast k-means initialisation

In this paper we make two novel contributions to hierarchical clustering. First, we introduce an anomalous pattern initialisation method for hierarchical clustering algorithms, called A-Ward, capable of substantially reducing the time they take to converge. This method generates an initial partition with a sufficiently large number of clusters. This allows the cluster merging process to start from this partition rather than from a trivial partition composed solely of singletons.\ud
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Our second contribution is an extension of the Ward and Wardp algorithms to the situation where the feature weight exponent can differ from the exponent of the Minkowski distance. This new method, called A-Wardpβ, is able to generate a much wider variety of clustering solutions. We also demonstrate that its parameters can be estimated reasonably well by using a cluster validity index.\ud
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We perform numerous experiments using data sets with two types of noise, insertion of noise features and blurring within-cluster values of some features. These experiments allow us to conclude: (i) our anomalous pattern initialisation method does indeed reduce the time a hierarchical clustering algorithm takes to complete, without negatively impacting its cluster recovery ability; (ii) A-Wardpβ provides better cluster recovery than both Ward and Wardp
Far-infrared transmission in GaN,AlN and AlGaN thin films grown by molecular beam epitaxy

We present a far-infrared transmission study on group-III nitride thin films. Cubic GaN and AlN layers and c-oriented wurtzite GaN, AlN, and AlxGa1−xN (x<0.3) layers were grown by molecular beam epitaxy on GaAs and Si(111) substrates, respectively. The Berreman effect allows us to observe simultaneously the transverse optic and the longitudinal optic phonons of both the cubic and the hexagonal films as transmission minima in the infrared spectra acquired with obliquely incident radiation. We discuss our results in terms of the relevant electromagnetic theory of infrared transmission in cubic and wurtzite thin films. We compare the infrared results with visible Raman-scattering measurements. In the case of films with low scattering volumes and/or low Raman efficiencies and also when the Raman signal of the substrate material obscures the weaker peaks from the nitride films, we find that the Berreman technique is particularly useful to complement Raman spectroscop
Destination Marketing Organizations and destination marketing :
                    A narrative analysis of the literature

This document is the Accepted Manuscript version of the following article: Stephen Pike, and Stephen J. Page, ???Destination Marketing Organizations and destination marketing: A??narrative analysis of the literature???, Tourism Management, Vol. 41: 202-227, April 2014, made available under the terms of the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ The final, definitive Version of Record is available online via DOI: https://doi.org/10.1016/j.tourman.2013.09.009This article presents the first narrative analysis of the areas of research that have developed within the destination marketing field since its commencement in 1973. Given the broad extent of the field, and the absence of any previous reviews in four decades, a key challenge is in providing a focus for such a disparate body of knowledge. The review is structured around one principal question: 'To what extent is the Destination Marketing Organisation (DMO) responsible for the competitiveness of the destination?'. In pursuit of this underlying question, we address a number of themes including nomenclature and the DMO, the evolution of the destination marketing literature, competitiveness as the DMO reason d'??tre, and DMO effectiveness including issues of branding and positioning, and future research themes in the field
Cultural and Gender Convergence in Adolescent Drunkenness Evidence From 23 European and North American Countries

Contains fulltext :
                  99213.pdf (publisher's version ) (Open Access)Objective: To investigate time-trend changes in the frequency of drunkenness among European and North American adolescents.
Design: Cross-sectional surveys in the 1997/1998 and 2005/2006 Health Behaviour in School-Aged Children Study (HBSC).
Setting: High schools in 23 countries.
Participants: A sample of 77 586 adolescents aged 15 years was analyzed by means of hierarchical linear modeling.
Main Outcome Measure: The frequency of drunkenness.
Results: We observed a significant increase of about 40% in the mean frequency of drunkenness in all 7 participating Eastern European countries. This increase was evident among both genders, but most consistently among girls. Meanwhile, it declined in 13 of 16 Western countries, about 25% on average. Declines in Western countries were particularly notable among boys and in North America, Scandinavia, the United Kingdom, and Ireland. Despite this gender convergence, with few exceptions (Greenland, Norway, United Kingdom) boys continued to have a higher frequency of drunkenness in 2005/2006 than girls.
Conclusions: The confirmed cultural convergence implies that adoption and implementation of evidence-based measures to mitigate the frequency of adolescent drunkenness such as tax increases and restricting alcohol access and advertisement should get the same priority in Eastern European countries as in Western countries. Policy measures that might facilitate decreases in drunkenness such as server training and the promotion of alcohol-free leisure-time activities should be reinforced in Western countries. The gender convergence implies that prevention policy should be less exclusively focused on male adolescents
Finite-size scaling investigation of the liquid-liquid critical point in ST2 water and its stability with respect to crystallization.

The liquid-liquid critical point scenario of water hypothesizes the existence of two metastable liq- uid phases low-density liquid (LDL) and high-density liquid (HDL) deep within the supercooled region. The hypothesis originates from computer simulations of the ST2 water model, but the stabil- ity of the LDL phase with respect to the crystal is still being debated. We simulate supercooled ST2 water at constant pressure, constant temperature, and constant number of molecules N for N ≤ 729 and times up to 1 μs. We observe clear differences between the two liquids, both structural and dynamical. Using several methods, including finite-size scaling, we confirm the presence of a liquid-liquid phase transition ending in a critical point. We find that the LDL is stable with respect to the crystal in 98% of our runs (we perform 372 runs for LDL or LDL-like states), and in 100% of our runs for the two largest system sizes (N = 512 and 729, for which we perform 136 runs for LDL or LDL-like states). In all these runs, tiny crystallites grow and then melt within 1 μs. Only for N ≤ 343 we observe six events (over 236 runs for LDL or LDL-like states) of spontaneous crystal- lization after crystallites reach an estimated critical size of about 70 ± 10 molecules
Ultra-thin oxide films for band engineering:design principles and numerical experiments

The alignment of band energies between conductive oxides and semiconductors is crucial for the further development of oxide contacting layers in electronic devices. The growth of ultra thin films on the surface of an oxide material can be used to introduce a dipole moment at that surface due to charge differences. The dipole, in turn, alters the electrostatic potential - and hence the band energies - in the substrate oxide. We demonstrate the fundamental limits for the application of thin-films in this context, applying analytical and numerical simulations, that bridge continuum and atomistic. The simulations highlight the different parameters that can affect the band energy shifting potential of a given thin-film layer, taking the examples of MgO and SnO2. In particular we assess the effect of formal charge, layer orientation, layer thickness and surface coverage, with respect to their effect on the electrostatic potential. The results establish some design principles, important for further development and application of thin-films for band energy engineering in transparent conductive oxide materials
Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.

The ubiquitin-conjugating yeast enzyme RAD6 and its human homologs hHR6A and hHR6B are implicated in postreplication repair and damage-induced mutagenesis. The yeast protein is also required for sporulation and may modulate chromatin structure via histone ubiquitination. We report the phenotype of the first animal mutant in the ubiquitin pathway: inactivation of the hHR6B-homologous gene in mice causes male infertility. Derailment of spermatogenesis becomes overt during the postmeiotic condensation of chromatin in spermatids. These findings provide a parallel between yeast sporulation and mammalian spermatogenesis and strongly implicate hHR6-dependent ubiquitination in chromatin remodeling. Since heterozygous male mice and even knockout female mice are completely normal and fertile and thus able to transmit the defect, similar hHR6B mutations may cause male infertility in man
Chromosomal disorders: estimating baseline birth prevalence and pregnancy outcomes worldwide.

Chromosomal disorders, of which Down syndrome is the most common, can cause multi-domain disability. In addition, compared to the general population, there is a higher frequency of death before the age of five. In many settings, large gaps in data availability have hampered policy-making, programme priorities and resource allocation for these important conditions. We have developed methods, which overcome this lack of data and allow estimation of the burden of affected pregnancies and their outcomes in different settings worldwide. For example, the methods include a simple equation relating the percentage of mothers 35 and over to Down syndrome birth prevalence. The results obtained provide a starting point for consideration of services that can be implemented for the care and prevention of these disorders.WHO Regional Office for the Eastern Mediterranean
Euler-Bernoulli beams from a symmetry standpoint-characterization of
  equivalent equations

We completely solve the equivalence problem for Euler-Bernoulli equation
using Lie symmetry analysis. We show that the quotient of the symmetry Lie
algebra of the Bernoulli equation by the infinite-dimensional Lie algebra
spanned by solution symmetries is a representation of one of the following Lie
algebras: $2A_1$, $A_1\oplus A_2$, $3A_1$, or $A_{3,3}\oplus A_1$. Each
quotient symmetry Lie algebra determines an equivalence class of
Euler-Bernoulli equations. Save for the generic case corresponding to arbitrary
lineal mass density and flexural rigidity, we characterize the elements of each
class by giving a determined set of differential equations satisfied by
physical parameters (lineal mass density and flexural rigidity). For each
class, we provide a simple representative and we explicitly construct
transformations that maps a class member to its representative. The maximally
symmetric class described by the four-dimensional quotient symmetry Lie algebra
$A_{3,3}\oplus A_1$ corresponds to Euler-Bernoulli equations homeomorphic to
the uniform one (constant lineal mass density and flexural rigidity) . We
rigorously derive some non-trivial and non-uniform Euler-Bernoulli equations
reducible to the uniform unit beam. Our models extend and emphasize the
symmetry flavor of Gottlieb's iso-spectral beams (Proceedings of the Royal
Society London A 413 (1987) 235-250
Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.

Major outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and corticosubcerebral axons (CSAs) headed to more caudal parts of the nervous system. Previous findings establish that transcriptional programs define cortical neuron identity and suggest that CTAs and thalamic axons may guide each other, but the mechanisms governing CTA versus CSA pathfinding remain elusive. Here, we show that thalamocortical axons are required to guide pioneer CTAs away from a default CSA-like trajectory. This process relies on a hold in the progression of cortical axons, or waiting period, during which thalamic projections navigate toward cortical axons. At the molecular level, Sema3E/PlexinD1 signaling in pioneer cortical neurons mediates a "waiting signal" required to orchestrate the mandatory meeting with reciprocal thalamic axons. Our study reveals that temporal control of axonal progression contributes to spatial pathfinding of cortical projections and opens perspectives on brain wiring
Search for very high energy gamma-ray emission from pulsar-pulsar wind nebula systems with the Magic telescope\ud

The MAGIC collaboration has searched for high-energy gamma-ray emission of some of the most promising pulsar candidates above an energy threshold of 50 GeV, an energy not reachable up to now by other ground-based instruments. Neither pulsed nor steady gamma-ray emission has been observed at energies of 100 GeV from the classical radio pulsars PSR J0205+6449 and PSR J2229+6114 (and their nebulae 3C58 and Boomerang, respectively) and the millisecond pulsar PSR J0218+4232. Here, we present the flux upper limits for these sources and discuss their implications in the context of current model predictions.\u