pinecone/core-2020-05-10-deduplication huggingface dataset:
Differential sympathetic activation induced by intermittent hypoxia and sleep loss in rats: Action of angiotensin (1-7)

The present study attempted to evaluate the effects of chronic intermittent hypoxia (CIH) associated with sleep restriction in hemodynamic parameters and the plasma renin-angiotensin system. Wistar-Hannover rats were submitted to isolated CIH exposure (1000-1600 h), sleep restriction (1600-1000 h), defined as 18-h paradoxical sleep deprivation followed by 6-h sleep permission period and CIH associated to sleep restriction for 21 days. the CIH and sleep restriction group showed a preferential increase in renal sympathetic nervous system (rSNA) associated with a reduction in plasma angiotensin (1-7) concentrations. However, CIH-sleep restriction rats did not modify rSNA and showed a higher angiotensin (1-7) concentration when compared to isolated CIH and sleep restriction. These results suggest that CIH and sleep restriction impaired the cardiovascular system, and its association to sleep loss can modify these effects by partially restoring circulating angiotensin (1-7). (C) 2010 Elsevier B.V. All rights reserved.Associacao Fundo de lncentivo a Psicofarmacologia (AFIP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Nephrol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Nephrol, BR-04024002 São Paulo, BrazilFAPESP: 98/14303-3CNPq: 558924/2008-5Web of Scienc
Enhancing chemotherapy efficacy in pten-deficient prostate tumors by activating the senescence-associated antitumor immunity

Prosenescence therapy has recently emerged as a novel therapeutic approach for treating cancer. However, this concept is challenged by conflicting evidence showing that the senescence-associated secretory phenotype (SASP) of senescent tumor cells can have pro- as well as antitumorigenic effects. Herein, we report that, in Pten-null senescent tumors, activation of the Jak2/Stat3 pathway establishes an immunosuppressive tumor microenvironment that contributes to tumor growth and chemoresistance. Activation of the Jak2/Stat3 pathway in Pten-null tumors is sustained by the downregulation of theprotein tyrosine phosphatase PTPN11/SHP2, providing evidence for the existence of a novel PTEN/SHP2 axis. Importantly, treatment with docetaxel in combination with a JAK2 inhibitor reprograms the SASP and improves the efficacy of docetaxel-induced senescence by triggering a strong antitumor immune response in Pten-null tumors. Altogether, these data demonstrate that immune surveillance of senescent tumor cells can be suppressed in specific genetic backgrounds but also evoked by pharmacological treatments.published_or_final_versio
Common variant at 16p11.2 conferring risk of psychosis.

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders)
The visual strategy specific to humans among hominids: A study using the gap-overlap paradigm.

Although an extensive body of literature exists on the cognitive underpinnings of gaze movements in macaques and humans, few studies have investigated this topic from a broader evolutionary perspective. This study used the gap-overlap paradigm to examine the timing of the gaze movements by four hominid species: humans, chimpanzees, gorillas, and orangutans. The saccade latency involved in shifting the gaze from central to peripheral stimuli was measured and compared under two conditions, gap and overlap. The central stimulus disappeared shortly before the onset of the peripheral stimulus under the gap condition, but it remained under the overlap condition. Although all species demonstrated similar saccade latencies under the gap condition, the species clearly differed from one another under the overlap condition, which may suggest their similar perceptual and motor mechanism of making a saccade on the one hand and their differential strategies for coping with the competition between two activities involving fixation and initiation of a saccade (i.e. central vs. peripheral visual stimuli) on the other hand. In particular, humans showed longer saccade latency under the overlap condition compared to the other great apes, which may reflect this species' unique means of visual processing
Hadronic Few-Body Systems in Chiral Dynamics

Hadronic composite states are introduced as few-body systems in hadron physics. The Λ(1405) resonance is a good example of the hadronic few-body systems. It has turned out that Λ(1405) can be described by hadronic dynamics in a modern technology which incorporates coupled channel unitarity framework and chiral dynamics. The idea of the hadronic Kbar N composite state of Λ(1405) is extended to kaonic few-body states. It is concluded that, due to the fact that K and N have similar interaction nature in s-wave Kbar couplings, there are few-body quasibound states with kaons systematically just below the break-up thresholds, like KbarNN, KbarKN and KbarKK, as well as Λ(1405) as a KbarN quasibound state and f0(980) and a0(980) as KbarK
Pattern formation of an epithelial tubule by mechanical instability during epididymal development.

A single epithelial tubule undergoes morphogenesis to form a functional shape during the development of internal organs; however, the mechanical processes that are directed by the molecular signals regulating tubular morphogenesis are poorly understood. Here, axial tubular buckling triggered by cell proliferation is shown to drive the morphogenesis of murine epididymal tubules through mechanical interactions between the developing epithelial tubule and its surrounding tissues. Through immunofluorescence labeling and mathematical modeling, epididymal tubule shape formation is found to depend on two factors: cell proliferation area in the tubule and mechanical resistance from the tissues surrounding the tubule. Moreover, experimental perturbations of these two factors alter the shape of the epididymal tubule as predicted by the mathematical model, suggesting that the shape of the epididymal tubule spontaneously emerges through mechanical coupling between developing tissues instead of by growing according to a predetermined fate
Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models.

Recent evidence suggests a role of transient receptor potential melastatin 2 (TRPM2) in immune and inflammatory responses. We previously reported that TRPM2 deficiency attenuated inflammatory and neuropathic pain in some pain mouse models, including formalin- or carrageenan-induced inflammatory pain, and peripheral nerve injury-induced neuropathic pain models, while it had no effect on the basal mechanical and thermal nociceptive sensitivities. In this study, we further explored the involvement of TRPM2 in various pain models using TRPM2-knockout mice. There were no differences in the chemonociceptive behaviors evoked by intraplantar injection of capsaicin or hydrogen peroxide between wildtype and TRPM2-knockout mice, while acetic acid-induced writhing behavior was significantly attenuated in TRPM2-knockout mice. In the postoperative incisional pain model, no difference in mechanical allodynia was observed between the two genotypes. By contrast, mechanical allodynia in the monosodium iodoacetate-induced osteoarthritis pain model and the experimental autoimmune encephalomyelitis model were significantly attenuated in TRPM2-knockout mice. Furthermore, mechanical allodynia in paclitaxel-induced peripheral neuropathy and streptozotocin-induced painful diabetic neuropathy models were significantly attenuated in TRPM2-knockout mice. Taken together, these results suggest that TRPM2 plays roles in a wide range of pathological pain models based on peripheral and central neuroinflammation, rather than physiological nociceptive pain
Online optimization of casualty processing in major incident response : an experimental analysis.

When designing an optimization model for use in mass casualty incident (MCI) response, the dynamic and uncertain nature of the problem environment poses a significant challenge. Many key problem parameters, such as the number of casualties to be processed, will typically change as the response operation progresses. Other parameters, such as the time required to complete key response tasks, must be estimated and are therefore prone to errors. In this work we extend a multi-objective combinatorial optimization model for MCI response to improve performance in dynamic and uncertain environments. The model is developed to allow for use in real time, with continuous communication between the optimization model and problem environment. A simulation of this problem environment is described, allowing for a series of computational experiments evaluating how model utility is influenced by a range of key dynamic or uncertain problem and model characteristics. It is demonstrated that the move to an online system mitigates against poor communication speed, while errors in the estimation of task duration parameters are shown to significantly reduce model utility
In search of the determinants of European asset market comovements.

We show, in a broad class of affine general equilibrium models with long-run risk, that the covariances between asset returns are linear functions of risk factors. We use a dynamic conditional correlation model to measure the covariances of stock and sovereign bond markets in the Euro Area. We use a new approach to measure risk factors based on Google search data. The factors explain 50 to 60% of the variation of the covariances between European stocks and 25 to 35% of the covariances between European bonds. The information improves the portfolio performance compared to an equally weighted portfolio
Cutting cost in service systems: are you running with scissors?

© John Wiley & Sons, Ltd. This is the accepted version of the following article: THENENT, N.E. ... et al, 2014. Cutting cost in service systems: are you running with scissors? Strategic Change, 23 (5-6), pp. 341-357, which has been published in final form at http://dx.doi.org/10.1002/jsc.1981A rigorous link between the domains of cost estimation, systems theory, and accident investigation reveals fundamental epistemological limitations of commonly employed cost models when dealing with the characteristics of servitization systems
Search for two-neutrino double electron capture on $^{124}$Xe with the
  XMASS-I detector

Double electron capture is a rare nuclear decay process in which two orbital
electrons are captured simultaneously in the same nucleus. Measurement of its
two-neutrino mode would provide a new reference for the calculation of nuclear
matrix elements whereas observation of its neutrinoless mode would demonstrate
lepton number violation. A search for two-neutrino double electron capture on
$^{124}$Xe is performed using 165.9 days of data collected with the XMASS-I
liquid xenon detector. No significant excess above background was observed and
we set a lower limit on the half-life as $4.7 \times 10^{21}$ years at 90%
confidence level. The obtained limit has ruled out parts of some theoretical
expectations. We obtain a lower limit on the $^{126}$Xe two-neutrino double
electron capture half-life of $4.3 \times 10^{21}$ years at 90% confidence
level as well.Comment: 6 pages, 3 figures, accepted for publication in Physics Letters
Cotangent models for integrable systems

We associate cotangent models to a neighbourhood of a Liouville torus in
symplectic and Poisson manifolds focusing on a special class called
$b$-Poisson/$b$-symplectic manifolds. The semilocal equivalence with such
models uses the corresponding action-angle coordinate theorems in these
settings: the theorem of Liouville-Mineur-Arnold [A74] for symplectic manifolds
and an action-angle theorem for regular Liouville tori in Poisson manifolds
[LMV11]. Our models comprise regular Liouville tori of Poisson manifolds but
also consider the Liouville tori on the singular locus of a $b$-Poisson
manifold. For this latter class of Poisson structures we define a twisted
cotangent model. The equivalence with this twisted cotangent model is given by
an action-angle theorem recently proved in [KMS16]. This viewpoint of cotangent
models provides a new machinery to construct examples of integrable systems,
which are especially valuable in the $b$-symplectic case where not many sources
of examples are known. At the end of the paper we introduce non-degenerate
singularities as lifted cotangent models on $b$-symplectic manifolds and
discuss some generalizations of these models to general Poisson manifolds.Comment: 25 pages; final version to appear at Communications in Mathematical
  Physic
Generalized Zee-Babu model with 750 GeV Diphoton Resonance

We propose a generalized Zee-Babu model with a global $U(1)$ B-L symmetry, in
which we classify the model in terms of the number of the hypercharge $N/2$ of
the isospin doublet exotic charged fermions. Corresponding to each of the
number of $N$, we need to introduce some multiply charged bosons in order to
make the exotic fields decay into the standard model fields. We also discuss
the muon anomalous magnetic moment and the diphoton excess depending on $N$,
and we show what kind of models are in favor of these phenomenologies.Comment: 21 pages, 3 figures, 1 table. published versio
GammaLib and ctools: A software framework for the analysis of
  astronomical gamma-ray data

The field of gamma-ray astronomy has seen important progress during the last
decade, yet there exists so far no common software framework for the scientific
analysis of gamma-ray telescope data. We propose to fill this gap by means of
the GammaLib software, a generic library that we have developed to support the
analysis of gamma-ray event data. GammaLib has been written in C++ and all
functionality is available in Python through an extension module. On top of
this framework we have developed the ctools software package, a suite of
software tools that enables building of flexible workflows for the analysis of
Imaging Air Cherenkov Telescope event data. The ctools are inspired by science
analysis software available for existing high-energy astronomy instruments, and
they follow the modular ftools model developed by the High Energy Astrophysics
Science Archive Research Center. The ctools have been written in Python and
C++, and can be either used from the command line, via shell scripts, or
directly from Python. In this paper we present the GammaLib and ctools software
versions 1.0 that have been released end of 2015. GammaLib and ctools are ready
for the science analysis of Imaging Air Cherenkov Telescope event data, and
also support the analysis of Fermi-LAT data and the exploitation of the COMPTEL
legacy data archive. We propose to use ctools as the Science Tools software for
the Cherenkov Telescope Array Observatory.Comment: 19 pages, 10 figures, accepted for publication in A&A, corrected X
  axis units in Figure 1
The abundance and thermal history of water ice in the disk surrounding
  HD142527 from the DIGIT Herschel Key Program

The presence or absence of ice in protoplanetary disks is of great importance
for the formation of planets. By enhancing the solid surface density and
increasing the sticking efficiency, ice catalyzes the rapid formation of
planetesimals and decreases the time scale for giant planet core accretion.
Aims: In this paper we analyse the composition of the outer disk around the
Herbig star HD~142527. We focus on the composition of the water ice, but also
analyse the abundances of previously proposed minerals. Methods: We present new
Herschel far infrared spectra and a re-reduction of archival data from the
Infrared Space Observatory (ISO). We model the disk using full 3D radiative
transfer to obtain the disk structure. Also, we use an optically thin analysis
of the outer disk spectrum to obtain firm constraints on the composition of the
dust component. Results: The water ice in the disk around HD~142527 contains a
large reservoir of crystalline water ice. We determine the local abundance of
water ice in the outer disk (i.e. beyond 130\,AU). The re-reduced ISO spectrum
differs significantly from that previously published, but matches the new
Herschel spectrum at their common wavelength range. In particular, we do not
detect any significant contribution from carbonates or hydrous silicates, in
contrast to earlier claims. Conclusions: The amount of water ice detected in
the outer disk requires $\sim80\,$\% of the oxygen atoms. This is comparable to
the water ice abundance in the outer solar system, in comets and in dense
interstellar clouds. The water ice is highly crystalline while the temperatures
where we detect it are too low to crystallize the water on relevant time
scales. We discuss the implications of this finding.Comment: Accepted for publication in A&
Effectiveness of mindfulness-based stress reduction and mindfulness based cognitive therapy in vascular disease: A systematic review and meta-analysis of randomised controlled trials.

OBJECTIVE: To determine the effectiveness of mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) on psychological and physical outcomes for people with vascular disease. DESIGN: Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES: AMED, CINAHL, EMBASE, British Nursing Index, Medline, Web of Science, PsycINFO, Cochrane Database of Systematic Reviews, Central, Social Sciences Citation Index, Social Policy and Practice, and HMIC from inception to January 2013. REVIEW METHODS: Articles were screened for inclusion independently by two reviewers. Data extraction and quality appraisal were performed by one reviewer and checked by a second with discrepancies resolved by discussion with a third if necessary. Random-effects meta-analyses were performed. RESULTS: Nine articles (from eight original randomised controlled trials) met eligibility criteria and were included in the final review. In total, 578 participants were enrolled across the trials, with participants presenting with prehypertension/hypertension (n=3 trials), type 1 or 2 diabetes (n=2), heart disease (n=2) and stroke (n=1). Meta-analyses, using standardised mean differences, showed evidence of reductions in stress (-0.36; 95% CI -0.67 to -0.09; p=0.01), depression (-0.35; 95% CI -0.53 to -0.16; p=0.003) and anxiety (-0.50; 95% CI -0.70 to -0.29; p<0.001). Effects on physical outcomes (blood pressure, albuminuria, stress hormones) were mixed. CONCLUSION: Whilst populations with vascular disease appear to derive a range of psychological benefits from MBSR/MBCT intervention, the effects on physical parameters of disease are not yet established. More robust studies, with longer term follow-up, are required to ascertain full effectiveness of such intervention.NIHRCLAHRCPenCLAHR
Sexual Problems among Japanese Women: Data from an Online Helpline.

[Introduction]Sexual problems have been more prevalent among East Asian women than those from other areas of the world. However, Japanese women seldom tend to consult their treating physicians as such intimate problems are socially awkward topics to share and may be considered shameful. Presently, there is little data in the literature regarding women's sexual problems in Japan. [Aims]We aimed (i) to investigate the types of sexual problems that were reported among Japanese women who had sought online consultations; and (ii) to examine whether factors such as age and family structure (marital status and presence of children) increased the likelihood of sexual problems. [Methods]An online helpline received a total of 316 messages from Japanese women related to sexual problems over a 3‐year period. We evaluated 276 respondents, who provided demographic information such as age and family structure as well as their response to an open‐ended question regarding their sexual problems. [Main Outcome Measures]Main outcome measures were the types of sexual problems reported by Japanese women. [Results]The majority of respondents were in their 30s (53.6%). Sexual aversion accounted for 42.4% of the complaints, partners' sexual issues for 18.5%, and pain during sex for 16.7%. Family structure significantly correlated with sexual problems (P < 0.001). Women with sexual aversion were more likely to be younger (P = 0.003) and have children (P < 0.001). Women whose partners had sexual issues were more likely to be married (P < 0.001) and have no children (P < 0.001). Women who reported pain during sex were more likely to have no children (P = 0.006). [Conclusion]Sexual aversion was the most common sexual problem among Japanese women who sought help via the online helpline. Family structure was related to sexual problems. More detailed assessments of family structure may be important in better identifying the triggering causes of the reported sexual problems. Ozaki Y, Nagao K, Saigo R, Tai T, Tanaka N, Kobayashi H, Nakajima K, and Takahashi Y. Sexual problems among Japanese women: Data from an online helpline. Sex Med 2015;3:289–295
Localizing Estimates of the Support of Solutions of some Nonlinear Schrödinger Equations - The Stationary Case

The main goal of this paper is to study the nature of the support of the solution of suitable nonlinear Schrödinger equations, mainly the compactness of the support and its spatial localization. This question touches the very foundations underlying the derivation of the Schrödinger equation, since it is well-known a solution of a linear Schrödinger equation perturbed by a regular potential never vanishes on a set of positive measure. A fact, which reflects the impossibility of locating the particle. Here we shall prove that if the perturbation involves suitable singular nonlinear terms then the support of the solution is a compact set, and so any estimate on its spatial localization implies very rich information on places not accessible by the particle. Our results are obtained by the application of certain energy methods which connect the compactness of the support with the local vanishing of a suitable "energy function" which satisfies a nonlinear differential inequality with an exponent less than one. The results improve and extend a previous short presentation by the authors published in 2006