pinecone/core-2020-05-10-deduplication huggingface dataset:
Consumo de sustancias en jóvenes adultos con TDAH: comorbilidad y síntomas de inatención e hiperactividad/impulsividad

Young adults with attention deficit hyperactivity disorder (ADHD) are at high risk of substance use (SU). The aims of the current study were: 1) to examine the use of alcohol, tobacco, marijuana and other illegal drugs by adults with and without ADHD; 2) to compare the oppositional, conduct, anxiety, depression, sleep and antisocial personality symptoms of ADHD adults with SU and ADHD adults without SU; 3) to examine the ability of ADHD symptoms and conduct problems to predict SU. A total of 93 young adults, 43 without ADHD and 50 with a childhood diagnosis of ADHD, who were part of the Spanish sample of the Multicenter ADHD Genetics (IMAGE) study, collaborated in a follow-up evaluation 10.1 years later. ADHD participants were divided into two groups based on the presence or absence of SU. Statistically significant differences were found between young adults with and without ADHD in their use of tobacco, marijuana and alcohol. A statistically significant association was also shown between externalization problems and a greater risk of SU. Conduct problems, to a greater degree than ADHD symptoms, affect SU in ADHD adults.Los jóvenes con trastorno por déficit de atención con hiperactividad (TDAH) tienen un elevado riesgo de uso de sustancias (US). Los objetivos del presente trabajo fueron: 1) analizar el consumo de alcohol, tabaco, marihuana y otras drogas ilegales en adultos con y sin TDAH; 2) comparar a los adultos con TDAH con y sin US en oposicionismo, problemas de conducta, ansiedad, depresión, sueño y personalidad antisocial; 3) determinar la capacidad de la sintomatología de TDAH y de los problemas de conducta para predecir el US. Noventa y tres jóvenes adultos, 43 sin TDAH y 50 con diagnóstico de TDAH en la infancia que participaron en el estudio Multicenter ADHD Genetics (IMAGE) colaboraron en una evaluación de seguimiento 10.1 años después. Los participantes con TDAH se dividieron en dos subgrupos según presencia o ausencia de US. Los jóvenes con y sin TDAH se diferenciaron significativamente en consumo de tabaco, marihuana y alcohol. Se constató una relación significativa entre los trastornos de conducta y US en adultos TDAH. Los problemas de conducta más que los síntomas de TDAH influyen en el US de adultos con TDAH
The simplest resonant spin-flavour solution to the solar neutrino problem

We re-analyse the resonant spin-flavour (RSF) solutions to the solar neutrino problem in the framework of analytic solutions to the solar magneto-hydrodynamics (MHD) equations. By substantially eliminating the arbitrariness associated to the magnetic field profile due to both mathematical consistency and physical requirements we propose the simplest scheme (MHD-RSF, for short) for solar neutrino conversion using realistic static MHD solutions. Using such effective two-parameter scheme we perform the first global fit of the recent solar neutrino data, including event rates as well as zenith angle distributions and recoil electron spectra induced by solar neutrino interactions in SuperKamiokande. We compare quantitatively our simplest MHD-RSF fit with vacuum oscillation (VAC) and MSW-type (SMA, LMA and LOW) solutions to the solar neutrino problem using a common well-calibrated theoretical calculation and fit procedure. We find our MHD-RSF fit to be somewhat better than those obtained for the favored neutrino oscillation solutions, though not in a statistically significant way with Deltam(2) approximate to 10(-8) eV(2) and sin(2) 2 theta = 0. We briefly discuss the prospects to disentangle our MHD-RSF scenario from oscillation-type solutions to the solar neutrino problem at future solar neutrino experiments, giving some predictions for the SNO experiment
4-[2-(Trimethylsilyl) Ethynyl]Benzoates: Synthesis and Evaluation for Mesomorphic Properties of some Novel Calamitic Molecules

A series of novel terminal trimethylsilylacetylene benzoate derivatives with various linking groups were synthesized using Friedel-Craft's O-acylation reaction. The chemical structures of the novel4-[2-(trimethylsilyl)ethynyl]benzoates were confirmed by standard spectroscopic techniques. The compounds were investigated for their liquid crystalline properties employing polarised optical microscopy and differential scanning calorimetry. The esters 5c – 5f, 5h and 5n possessing three phenyl rings exhibited liquid crystalline property of SmA/SmC phases with wide thermal range
Deviations from Born-Oppenheimer mass scaling in spectroscopy and
  ultracold molecular physics

We investigate Born-Oppenheimer breakdown (BOB) effects (beyond the usual
mass scaling) for the electronic ground states of a series of homonuclear and
heteronuclear alkali-metal diatoms, together with the Sr$_2$ and Yb$_2$
diatomics. Several widely available electronic structure software packages are
used to calculate the leading contributions to the total isotope shift for
commonly occurring isotopologs of each species. Computed quantities include
diagonal Born-Oppenheimer corrections (mass shifts) and isotopic field shifts.
Mass shifts dominate for light nuclei up to and including K, but field shifts
contribute significantly for Rb and Sr and are dominant for Yb. We compare the
{\em ab initio} mass-shift functions for Li$_2$, LiK and LiRb with
spectroscopically derived ground-state BOB functions from the literature. We
find good agreement in the values of the functions for LiK and LiRb at their
equilibrium geometries, but significant disagreement with the shapes of the
functions for all 3 systems. The differences may be due to contributions of
nonadiabatic terms to the empirical BOB functions. We present a semiclassical
model for the effect of BOB corrections on the binding energies of
near-threshold states and the positions of zero-energy Feshbach resonances.Comment: 34 pages, 10 figure
Spectroscopic characterisation of microlensing events Towards a new
  interpretation of OGLE-2011-BLG-0417

The microlensing event OGLE-2011-BLG-0417 is an exceptionally bright lens
binary that was predicted to present radial velocity variation at the level of
several km/s. Pioneer radial velocity follow-up observations with the UVES
spectrograph at the ESO - VLT of this system clearly ruled out the large radial
velocity variation, leaving a discrepancy between the observation and the
prediction. In this paper, we further characterise the microlensing system by
analysing its spectral energy distribution (SED) derived using the UVES
spectrum and new observations with the ARCoIRIS (CTIO) near-infrared
spectrograph and the Keck adaptive optics instrument NIRC2 in the J, H, and Ks
bands. We determine the mass and distance of the stars independently from the
microlensing modelling. We find that the SED is compatible with a giant star in
the Galactic bulge and a foreground star with a mass of 0.94+/-0.09Msun at a
distance of 1.07+/-0.24kpc. We find that this foreground star is likely the
lens. Its parameters are not compatible with the ones previously reported in
the literature (0.52+/-0.04Msun at 0.95+/-0.06kpc), based on the microlensing
light curve. A thoughtful re-analysis of the microlensing event is mandatory to
fully understand the reason of this new discrepancy. More importantly, this
paper demonstrates that spectroscopic follow-up observations of microlensing
events are possible and provide independent constraints on the parameters of
the lens and source stars, hence breaking some degeneracies in the analysis.
UV-to-NIR low-resolution spectrographs like X-SHOOTER (ESO - VLT) could
substantially contribute to this follow-up efforts, with magnitude limits above
all microlensing events detected so far.Comment: accepted for publication in A&A Letter
Measurement of the W±Z boson pair-production cross section in pp collisions at s=13 TeV with the ATLAS detector

The production of W±ZW±Z events in proton–proton collisions at a centre-of-mass energy of 13 TeV13 TeV is measured with the ATLAS detector at the LHC. The collected data correspond to an integrated luminosity of 3.2 fb−13.2 fb−1. The W±ZW±Z candidates are reconstructed using leptonic decays of the gauge bosons into electrons or muons. The measured inclusive cross section in the detector fiducial region for leptonic decay modes is View the MathML sourceσW±Z→ℓ′νℓℓfid.=63.2±3.2(stat.)±2.6(sys.)±1.5(lumi.) fb. In comparison, the next-to-leading-order Standard Model prediction is View the MathML source53.4−2.8+3.6 fb. The extrapolation of the measurement from the fiducial to the total phase space yields View the MathML sourceσW±Ztot.=50.6±2.6(stat.)±2.0(sys.)±0.9(th.)±1.2(lumi.) pb, in agreement with a recent next-to-next-to-leading-order calculation of View the MathML source48.2−1.0+1.1 pb. The cross section as a function of jet multiplicity is also measured, together with the charge-dependent W+ZW+Z and W−ZW−Z cross sections and their ratio.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Knut and Alice Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, the Canada Council, Canarie, CRC, Compute Canada, FQRNT, and the Ontario Innovation Trust, Canada; EPLANET, ERC, FP7, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex and Idex, ANR, Region Auvergne and Fondation Partager le Savoir, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF; BSF, GIF and Minerva, Israel; BRF, Norway; Generalitat de Catalunya, Generalitat Valenciana, Spain; the Royal Society and Leverhulme Trust, United Kingdom
The Instantaneous wave-Free Ratio (iFR) pullback: a novel innovation using baseline physiology to optimise coronary angioplasty in tandem lesions.

28.05.15 KB. Ok to add published version to spiral, oa paper© 2015 The Authors.Coronary intervention is increasingly performed in complex disease with tandem and diffuse disease. Pressure wires enable detailed assessment of the physiological significance of a stenosis but in the presence of tandem disease, predicting the impact of a stenting a given stenosis can be difficult and is impeded by flow interaction between stenoses under hyperemia. In this review, we consider the physiological difficulties posed by flow interaction under hyperemia and consider alternative approaches such as assessment under baseline conditions. Specifically we consider the potential value of the iFR-Pullback approach and its capacity to enable Virtual-PCI, which may assist in planning intervention
Circadian regulation of slow waves in human sleep:Topographical aspects

Slow waves (SWs, 0.5-4Hz) in field potentials during sleep reflect synchronized alternations between bursts of action potentials and periods of membrane hyperpolarization of cortical neurons. SWs decline during sleep and this is thought to be related to a reduction of synaptic strength in cortical networks and to be central to sleep's role in maintaining brain function. A central assumption in current concepts of sleep function is that SWs during sleep, and associated recovery processes, are independent of circadian rhythmicity. We tested this hypothesis by quantifying all SWs from 12 EEG derivations in 34 participants in whom 231 sleep periods were scheduled across the circadian cycle in a 10-day forced-desynchrony protocol which allowed estimation of the separate circadian and sleep-dependent modulation of SWs. Circadian rhythmicity significantly modulated the incidence, amplitude, frequency and the slope of the SWs such that the peaks of the circadian rhythms in these slow-wave parameters were located during the biological day. Topographical analyses demonstrated that the sleep-dependent modulation of SW characteristics was most prominent in frontal brain areas whereas the circadian effect was similar to or greater than the sleep-dependent modulation over the central and posterior brain regions. The data demonstrate that circadian rhythmicity directly modulates characteristics of SWs thought to be related to synaptic plasticity and that this modulation depends on topography. These findings have implications for the understanding of local sleep regulation and conditions such as ageing, depression, and neurodegeneration which are associated with changes in SWs, neural plasticity and circadian rhythmicity
Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner.

Upon infection, antigen-specific naive CD8 T cells are activated and differentiate into short-lived effector cells (SLECs) and memory precursor cells (MPECs). The underlying signaling pathways remain largely unresolved. We show that Rictor, the core component of mammalian target of rapamycin complex 2 (mTORC2), regulates SLEC and MPEC commitment. Rictor deficiency favors memory formation and increases IL-2 secretion capacity without dampening effector functions. Moreover, mTORC2-deficient memory T cells mount more potent recall responses. Enhanced memory formation in the absence of mTORC2 was associated with Eomes and Tcf-1 upregulation, repression of T-bet, enhanced mitochondrial spare respiratory capacity, and fatty acid oxidation. This transcriptional and metabolic reprogramming is mainly driven by nuclear stabilization of Foxo1. Silencing of Foxo1 reversed the increased MPEC differentiation and IL-2 production and led to an impaired recall response of Rictor KO memory T cells. Therefore, mTORC2 is a critical regulator of CD8 T cell differentiation and may be an important target for immunotherapy interventions
Measurement of the t-channel single top-quark production cross section in pp collisions at √s = 7 TeV with the ATLAS detector

We report a measurement of the cross section of single top-quark production in the t  -channel using 1.04 fb[superscript −1] of pp  collision data at √s = 7 TeV recorded with the ATLAS detector at the LHC. Selected events feature one electron or muon, missing transverse momentum, and two or three jets, exactly one of them identified as originating from a b   quark. The cross section is measured by fitting the distribution of a multivariate discriminant constructed with a neural network, yielding [formula] which is in good agreement with the prediction of the Standard Model. Using the ratio of the measured to the theoretically predicted cross section and assuming that the top-quark-related CKM matrix elements obey the relation |Vtb|>>|Vts|, |Vtd|, the coupling strength at the W -t -b  vertex is determined to be . If it is assumed that |Vtb|[less than or equal to] 1 a lower limit of [formula] is obtained at the 95% confidence level.Brookhaven National LaboratoryUnited States. Dept. of EnergyNational Science Foundation (U.S.
An update on EMU sovereign yield spreads drivers in times of crisis: A panel data analysis

respect to the German bund. Using panel data techniques, we examine the role of a wide set of potential drivers. To our knowledge, this paper presents one of the most exhaustive compilations of the variables used in the literature to study the behaviour of sovereign yield spreads and, in particular, to gauge the effect on these spreads of changes in market sentiment and risk aversion. We use a sample of both central and peripheral countries from January 1999 to December 2012 and assess whether there were significant changes after the outbreak of the euro area debt crisis. Our results suggest that the rise in sovereign risk in central countries can only be partially explained by the evolution of local macroeconomic variables in those countries. Besides, without exception, the marginal effects of sovereign spread drivers (specifically, the variables that measure global market sentiment) increased during the crisis compared to the pre-crisis period, especially in peripheral countries. Moreover, the increase in the significance of the banking level of indebtedness and foreign bank's claims in the public sector (mainly in peripheral countries) along with the crisis unfolding seems to highlight the interconnection between private and public debt and thus, between banking and sovereign crises
Cluster analysis of diffusion tensor field with application to the segmentation of the Corpus Callosum

This paper was presented at the International Conference On Medical Imaging Understanding and Analysis  (MIUA 2016), Loughborough, UK, 6-8th July. This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 4.0 Attribution-NonCommercial-NoDerivatives Licence (CC BY-NC-ND). Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/4.0/Accurate segmentation of the Corpus Callosum (CC) is an important aspect of clinical medicine and is used in the diagnosis of\ud
various brain disorders. In this paper, we propose an automated method for two and three dimensional segmentation of the CC\ud
using diffusion tensor imaging. It has been demonstrated that Hartigan’s K-means is more efficient than the traditional Lloyd\ud
algorithm for clustering. We adapt Hartigan’s K-means to be applicable for use with the metrics that have a f -mean (e.g. Cholesky, root Euclidean and log Euclidean). Then we applied the adapted Hartigan’s K-means, using Euclidean, Cholesky, root Euclidean and log Euclidean metrics along with Procrustes and Riemannian metrics (which need numerical solutions for mean computation), to diffusion tensor images of the brain to provide a segmentation of the CC. The log Euclidean and Riemannian metrics provide more accurate segmentations of the CC than the other metrics as they present the least variation of the shape and size of the tensors in the CC for 2D segmentation. They also yield a full shape of the splenium for the 3D segmentation
A search for high-mass resonances decaying to T(+) T(-)in pp collisions at root s = 8 TeV with the ATLAS detectorr

A search for high-mass resonances decaying into τ+τ− final states using proton-proton collisions at √s=8 TeV produced by the Large Hadron Collider is presented. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 19.5–20.3 fb⁻¹. No statistically significant excess above the Standard Model expectation is observed; 95% credibility upper limits are set on the cross section times branching fraction of Z′ resonances decaying into τ⁺τ⁻ pairs as a function of the resonance mass. As a result, Z′ bosons of the Sequential Standard Model with masses less than 2.02 TeV are excluded at 95% credibility. The impact of the fermionic couplings on the Z′ acceptance is investigated and limits are also placed on a Z′ model that exhibits enhanced couplings to third-generation fermions.G. Aad ... P. Jackson ... L. Lee ... A. Petridis ... N. Soni ... M.J. White ... et al. (ATLAS Collaboration
Bystander effects and their implications for clinical radiation therapy : insights from multiscale in silico experiments

GGP and MAJC thank University of Dundee, where this research was carried out. The authors gratefully acknowledge the support of the ERC Advanced Investigator Grant 227619, M5CGS - From Mutations to Metastases: Multiscale Mathematical Modelling of Cancer Growth and Spread. AJM Acknowledges support from EU BIOMICS Project DG-CNECT Contract 318202.Radiotherapy is a commonly used treatment for cancer and is usually given in varying doses. At low radiation doses relatively few cells die as a direct response to radiation but secondary radiation effects, such as DNA mutation or bystander phenomena, may affect many cells. Consequently it is at low radiation levels where an understanding of bystander effects is essential in designing novel therapies with superior clinical outcomes. In this article, we use a hybrid multiscale mathematical model to study the direct effects of radiation as well as radiation-induced bystander effects on both tumour cells and normal cells. We show that bystander responses play a major role in mediating radiation damage to cells at low-doses of radiotherapy, doing more damage than that due to direct radiation. The survival curves derived from our computational simulations showed an area of hyper-radiosensitivity at low-doses that are not obtained using a traditional radiobiological model.PostprintPeer reviewe
Yang–Baxter sigma models based on the CYBE

AbstractIt is known that Yang–Baxter sigma models provide a systematic way to study integrable deformations of both principal chiral models and symmetric coset sigma models. In the original proposal and its subsequent development, the deformations have been characterized by classical r-matrices satisfying the modified classical Yang–Baxter equation (mCYBE). In this article, we propose the Yang–Baxter sigma models based on the classical Yang–Baxter equations (CYBE) rather than the mCYBE. This generalization enables us to utilize various kinds of solutions of the CYBE to classify integrable deformations. In particular, it is straightforward to realize partial deformations of the target space without loss of the integrability of the parent theory
Functional Properties of Dendritic Gap Junctions in Cerebellar Golgi Cells

SummaryThe strength and variability of electrical synaptic connections between GABAergic interneurons are key determinants of spike synchrony within neuronal networks. However, little is known about how electrical coupling strength is determined due to the inaccessibility of gap junctions on the dendritic tree. We investigated the properties of gap junctions in cerebellar interneurons by combining paired somato-somatic and somato-dendritic recordings, anatomical reconstructions, immunohistochemistry, electron microscopy, and modeling. By fitting detailed compartmental models of Golgi cells to their somato-dendritic voltage responses, we determined their passive electrical properties and the mean gap junction conductance (0.9 nS). Connexin36 immunofluorescence and freeze-fracture replica immunogold labeling revealed a large variability in gap junction size and that only 18% of the 340 channels are open in each plaque. Our results establish that the number of gap junctions per connection is the main determinant of both the strength and variability in electrical coupling between Golgi cells
Production of two charm quark–antiquark pairs in single-parton scattering within the kt-factorization approach

AbstractWe present first results for the 2→4 single-parton scattering gg→cc¯cc¯ subprocess for the first time fully within the kt-factorization approach. In this calculation we have used the Kimber–Martin–Ryskin unintegrated gluon distribution which effectively includes some class of higher-order gluon emissions, and an off-shell matrix element squared calculated using recently developed techniques. The results are compared with our earlier result obtained within the collinear-factorization approach. Only slightly larger cross sections are obtained than in the case of the collinear approach. Inclusion of transverse momenta of gluons entering the hard process leads to a much stronger azimuthal decorrelation between cc and c¯c¯ than in the collinear-factorization approach. A comparison to predictions of double parton scattering (DPS) results and the LHCb data strongly suggests that the assumption of two fully independent DPS (gg→cc¯⊗gg→cc¯) may be too approximate