pinecone/core-2020-05-10-deduplication huggingface dataset:
Development of an ATCA IPMI controller mezzanine board and its usage on an ATCA ROD evaluator board for the ATLAS LAr upgrade

International audienceIn the context of the LHC upgrades, a new Read-Out Driver (ROD) board for the ATLAS LAr calorimeter is being developed. xTCA (Advanced/Micro Telecom Computing Architecture) is becoming a standard in high energy physics and is a serious candidate for future readout systems. We will present our current developments to master ATCA and to integrate a large number of very high speed links (96 links/8.5 Gbps) on a ROD Evaluator ATCA board. To manage our ROD Evaluator, we have developed a versatile ATCA IPMI controller for ATCA boards which is FPGA Mezzanine Card (FMC) compliant
Energy of tsunami waves generated by bottom motion

20 pages, 12 figures. Accepted to Proceedings of the Royal Society A. Other authors papers and supporting material can be downloaded at http://www.lama.univ-savoie.fr/~dutykhInternational audienceIn the vast literature on tsunami research, few articles have been devoted to energy issues. A theoretical investigation on the energy of waves generated by bottom motion is performed here. We start with the full incompressible Euler equations in the presence of a free surface and derive both dispersive and non-dispersive shallow-water equations with an energy equation. It is shown that dispersive effects only appear at higher order in the energy budget. Then we solve the Cauchy-Poisson problem of tsunami generation for the linearized water wave equations. Exchanges between potential and kinetic energies are clearly revealed
Self Determination-Based Design To Achieve Acceptance of Assisted Living Technologies For Older Adults

Accepted for publication in the journal Computers In Human BehaviorInternational audienceProviding technological support to assist older adults in their daily activities is a promising approach to aging in place. However, acceptance is critical when technologies are embedded in the user's life. Recently, Lee et al. established a connection between acceptance and motivation. They approached motivation via the Self-Determination Theory (SDT): the capacity to make choices and to take decisions. This paper leverages SDT to promote a new design style for gerontechnologies that consists of principles and requirements. We applied our approach to develop an assisted living platform, which was used to conduct a six-month field study with 34 older adults. We show that self-determination is a determining factor of technology acceptance. Furthermore, our platform improved the self-determination of equipped participants, compared to the control group, suggesting that our approach is effective. As such, SDT opens up new opportunities for improving the design process of geron-technologies
Multi-Rate Mass Transfer (MRMT) models for general diffusive porosity structures

International audienceWe determine the relevance of Multi-Rate Mass Tansfer (MRMT) models to general diffusive porosity structures. To this end, we introduce Structured INteracting Continua models (SINC) as the combination of a finite number of diffusion-dominated interconnected immobile zones exchanging with an advection-dominated mobile domain. It directly extends Multiple INteracting Continua framework [34] by introducing a structure in the immobile domain, coming for example from the dead-ends of fracture clusters or poorly-connected dissolution patterns. We demonstrate that, whatever their structure, SINC models can be made equivalent in terms of concentration in the mobile zone to a unique Multi-Rate Mass Transfer (MRMT) model [21]. We develop effective shape-free numerical methods to identify its few dominant rates, that comply with any distribution of rates and porosities. We show that differences in terms of macrodispersion are not larger than 50% for approximate MRMT models with only one rate (double porosity models), and drop down to less than 0.1% for five rates MRMT models. Low-dimensional MRMT models accurately approach transport in structured diffusive porosities at intermediate and long times and only miss early responses
Refinement and Difference for Probabilistic Automata

International audienceThis paper studies a difference operator for stochastic systems whose specifications are represented by Abstract Probabilistic Automata (APAs). In the case refinement fails between two specifications, the target of this operator is to produce a specification APA that represents all witness PAs of this failure. Our contribution is an algorithm that allows to approximate the difference of two deterministic APAs with arbitrary precision. Our technique relies on new quantitative notions of distances between APAs used to assess convergence of the approximations as well as on an in-depth inspection of the refinement relation for APAs. The procedure is effective and not more complex than refinement checking
Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study.

International audiencePURPOSE: Frailty is a recent concept used for evaluating elderly individuals. Our study determined the prevalence of frailty in intensive care unit (ICU) patients and its impact on the rate of mortality. METHODS: A multicenter, prospective, observational study performed in four ICUs in France included 196 patients aged ≥65 years hospitalized for >24 h during a 6-month study period. Frailty was determined using the frailty phenotype (FP) and the clinical frailty score (CFS). The patients were separated as follows: FP score <3 or ≥3 and CFS <5 or ≥5. RESULTS: Frailty was observed in 41 and 23% of patients on the basis of an FP score ≥3 and a CFS ≥5, respectively. At admission to the ICU, the Simplified Acute Physiology Score II (SAPS II) and Sequential Organ Failure Assessment (SOFA) scores did not differ between the frail and nonfrail patients. In the multivariate analysis, the risk factors for ICU mortality were FP score ≥3 [hazard ratio (HR), 3.3; 95% confidence interval (CI), 1.6-6.6; p < 0.001], male gender (HR, 2.4; 95% CI, 1.1-5.3; p = 0.026), cardiac arrest before admission (HR, 2.8; 95% CI, 1.1-7.4; p = 0.036), SAPS II score ≥46 (HR, 2.6; 95% CI, 1.2-5.3; p = 0.011), and brain injury before admission (HR, 3.5; 95% CI, 1.6-7.7; p = 0.002). The risk factors for 6-month mortality were a CFS ≥5 (HR, 2.4; 95% CI, 1.49-3.87; p < 0.001) and a SOFA score ≥7 (HR, 2.2; 95% CI, 1.35-3.64; p = 0.002). An increased CFS was associated with significant incremental hospital and 6-month mortalities. CONCLUSIONS: Frailty is a frequent occurrence and is independently associated with increased ICU and 6-month mortalities. Notably, the CFS predicts outcomes more effectively than the commonly used ICU illness scores
Finger creases lend a hand in Kabuki syndrome.

International audienceKabuki syndrome (KS) is a rare syndrome associating malformations with intellectual deficiency and numerous visceral, orthopedic, endocrinological, immune and autoimmune complications. The early establishment of a diagnostic of KS leads to better care of the patients and therefore prevents complications such as perception deafness, severe complications of auto-immune diseases or obesity. However, the diagnosis of KS remains difficult because based on the appreciation of facial features combined with other highly variable features. We describe a novel sign, namely the attenuation and/or congenital absence of the IPD crease of the third and fourth fingers associated with limitation of flexion of the corresponding joints, which seems to be specific of KS and could help the clinician to diagnose KS
From EEG signals to brain connectivity: a model-based evaluation of interdependence measures.

International audienceIn the past, considerable effort has been devoted to the development of signal processing techniques aimed at characterizing brain connectivity from signals recorded from spatially-distributed regions during normal or pathological conditions. In this paper, three families of methods (linear and nonlinear regression, phase synchronization, and generalized synchronization) are reviewed. Their performances were evaluated according to a model-based methodology in which a priori knowledge about the underlying relationship between systems that generate output signals is available. This approach allowed us to relate the interdependence measures computed by connectivity methods to the actual values of the coupling parameter explicitly represented in various models of signal generation. Results showed that: (i) some of the methods were insensitive to the coupling parameter; (ii) results were dependent on signal properties (broad band versus narrow band); (iii) there was no "ideal" method, i.e., none of the methods performed better than the other ones in all studied situations. Nevertheless, regression methods showed sensitivity to the coupling parameter in all tested models with average or good performances. Therefore, it is advised to first apply these "robust" methods in order to characterize brain connectivity before using more sophisticated methods that require specific assumptions about the underlying model of relationship. In all cases, it is recommended to compare the results obtained from different connectivity methods to get more reliable interpretation of measured quantities with respect to underlying coupling. In addition, time-frequency methods are also recommended when coupling in specific frequency sub-bands ("frequency-locking") is likely to occur as in epilepsy
Measures for the exceptionality of gene order in conserved genomic regions

International audienceWe propose in this article three measures for quantifying the exceptionality of gene order in conserved genomic regions found by the reference region approach. The three measures are based on the transposition distance in the permutation group. We obtain analytic expressions for their distribution in the case of a random uniform permutation, i.e. under the null hypothesis of random gene order. Our results can be used to increase the power of the significance tests for gene clusters which take into account only the proximity of the orthologous genes and not their order
Compliance error compensation technique for parallel robots composed of non-perfect serial chains

International audienceThe paper presents the compliance errors compensation technique for over-constrained parallel manipulators under external and internal loadings. This technique is based on the non-linear stiffness modeling which is able to take into account the influence of non-perfect geometry of serial chains caused by manufacturing errors. Within the developed technique, the deviation compensation reduces to an adjustment of a target trajectory that is modified in the off-line mode. The advantages and practical significance of the proposed technique are illustrated by an example that deals with groove milling by the Orthoglide manipulator that considers different locations of the workpiece. It is also demonstrated that the impact of the compliance errors and the errors caused by inaccuracy in serial chains cannot be taken into account using the superposition principle
Full scale experimentation on a new translucent passive solar wall combining silica aerogels and phase change materials

International audienceThis paper presents the first passive solar wall providing simultaneously super insulation, heat storage and daylighting to the inner space. The wall’s external layer is composed of a silica aerogels bed for high insulation and solar radiation transmission. The second layer, internal, is composed of glass bricks filled with a eutectic phase change material (PCM) for heat storage and restitution. The whole wall is translucent. The experimentations carried out to characterize thermal and optical properties of the materials used are described. Then results are given for a full scale comparative experimentation on a twin zones building located in the south of France for the solar wall and a standard opaque high thermal capacity wall. Results show the heat losses through the wall are very low while the heat and light gains are high: The U value of the solar wall is 0.59 W m−1 K−1 and 0.72 W m−1 K−1 respectively when the PCM is in liquid and solid state. With the test building in free floating condition, the temperature difference between the outdoor and indoor air provided by the wall is about 9 °C in winter. The wall can provide up to 500 lux to the inner environment, which is sufficient for conference rooms. The tested wall has proven more effective in winter and shoulder season, particularly for cold sunny climates, but may cause overheating in summer
Negotiating a Voluntary Agreement When Firms Self-Regulate

CERNA Working Paper Series 2010-18International audienceDoes self-regulation improve social welfare? We develop a policy game featuring a regulator and a firm that can unilaterally commit to better environmental or social behavior in order to preempt future public policy. We show that the answer depends on the set of policy instruments available to the regulator. Self-regulation improves welfare if the regulator can only use mandatory regulation: it reduces welfare when the regulator opts for a voluntary agreement. This suggests that self-regulation and voluntary agreements are not good complements from a welfare point of view. We derive the policy implications, and extend the basic model in several dimensions
Adding virtual measuring stations to a network for urban air pollution mapping

International audienceMaps of pollutants concentration are usually generated by means of interpolation and extrapolation methods. The quality of the results depends mainly of the number of permanent or temporary measuring stations. This paper deals with a method for the virtual densification of the network of stations. The method creates “virtual measuring stations”. It aims at improving the quality of interpolation by increasing the number of data on pollutant concentration. The virtual stations are determined by the means of a classification method applied to each pixel of the area under concern. Discriminating elements are pollutants emission classes, land cover types, urban morphological indicators created to this purpose and distance to major roads. A first implementation was made for particulate matter (PM) for the city of Strasbourg (France) using thin-plates spline interpolation method in Arcview 9 GIS. The relative Root Mean Square Error decreases from 49% for five input stations down to 15% for the virtual stations
A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)

International audienceGlioblastoma multiforme is the most aggressive primary tumor of the central nervous system. Glioma stem cells (GSCs), a small population of tumor cells with stem-like properties, are supposedly responsible for glioblastoma multiforme relapse after current therapies. In approximately thirty percent of glioblastoma multiforme tumors, telomeres are not maintained by telomerase but through an alternative mechanism, termed alternative lengthening of telomere (ALT), suggesting potential interest in developing specific therapeutic strategies. However, no preclinical model of ALT glioma was available until the isolation of TG20 cells from a human ALT glioma. Herein, we show that TG20 cells exhibit a high level of telomeric recombination but a stable karyotype, indicating that their telomeres retain their protective function against chromosomal instability. TG20 cells possess all of the characteristic features of GSCs: the expression of neural stem cell markers, the generation of intrace-rebral tumors in NOD-SCID-IL2Rc (NSG) mice as well as in nude mice, and the ability to sustain serial intracerebral transplan-tations without expressing telomerase, demonstrating the stability of the ALT phenotype in vivo. Furthermore, we also demonstrate that 360B, a G-quadruplex ligand of the pyridine derivative series that impairs telomere replication and mitotic progression in cancer cells, prevents the development of TG20 tumors. Together, our results show that intracerebral grafts of TG20 cells in immunodeficient mice constitute an efficient preclinical model of ALT glioblastoma multiforme and that G-quadruplex ligands are a potential therapy for this specific type of tumor
Ambiguous incentives and the persistence of effort: Experimental evidence

International audienceWhen the assignment of incentives is uncertain, we study how the regularity and frequency of rewards and risk attitudes influence participation and effort. We contrast three incentive schemes in a real-effort experiment in which individuals decide when to quit : a continuous incentive scheme and two intermittent ones, fixed and random. In all treatments, we introduce a regime shift by withdrawing monetary rewards after the same unknown number of periods. In such an ambiguous environment, we show that less able and more risk averse players are less persistent in effort. Intermittent incentives lead to a greater persistence of effort, while continuous incentives entail exit as soon as payment stops. Randomness increases both earlier and later exiting. This selection effect in terms of ability and risk attitudes combined with the impact of intermittent rewards on persistence lead to an increase in mean performance after the regime shift when incentives are intermittent
Fixed point strategies for elastostatic frictional contact problems

International audienceSeveral fixed point strategies and Uzawa algorithms (for classical and augmented Lagrangian formulations) are presented to solve the unilateral contact problem with Coulomb friction. These methods are analyzed, without introducing any regularization, and a theoretical comparison is performed. Thanks to a formalism coming from convex analysis, some new fixed point strategies are presented and compared to known methods. The analysis is first performed on continuous Tresca problem and then on the finite dimensional Coulomb problem derived from an arbitrary finite element method
Carbon-enhanced metal-poor stars: the most pristine objects?

International audienceCarbon-enhanced metal poor stars (CEMP) form a significant proportion of the metal-poor stars, their origin is not well understood. Three very metal-poor C-rich turnoff stars were selected from the SDSS survey, observed with the ESO VLT (UVES) to precisely determine the element abundances. In turnoff stars (unlike giants) the carbon abundance has not been affected by mixing with deep layers and is therefore easier to interpret. The analysis was performed with 1D LTE static model atmospheres. When available, non-LTE corrections were applied to the classical LTE abundances. The 3D effects on the CH and CN molecular bands were computed using hydrodynamical simulations of the stellar atmosphere (CO5BOLD) and are found to be very important. To facilitate a comparison with previous results, only 1D abundances are used in the discussion. The abundances (or upper limits) of the elements enable us to place these stars in different CEMP classes. The carbon abundances confirm the existence of a plateau at A(C)= 8.25 for [Fe/H] ≥ -3.4. The most metal-poor stars ([Fe/H] < -3.4) have significantly lower carbon abundances, suggesting a lower plateau at A(C) ≈ 6.5. Detailed analyses of a larger sample of very low metallicity carbon-rich stars are required to confirm (or refute) this possible second plateau and specify the behavior of the CEMP stars at very low metallicity
Bioanalytical characterisation of multiple endocrine- and dioxin-like activities in sediments from reference and impacted small rivers.

International audienceA comprehensive evaluation of organic contamination was performed in sediments sampled in two reference and three impacted small streams where endocrine disruptive (ED) effects in fish have been evidenced. The approach combined quantitative chemical analyses of more than 50 ED chemicals (EDCs) and a battery of in vitro bioassays allowing the quantification of receptor-mediated activities, namely estrogen (ER), androgen (AR), dioxin (AhR) and pregnane X (PXR) receptors. At the most impacted sites, chemical analyses showed the presence of natural estrogens, organochlorine pesticides, parabens, polycyclic aromatic hydrocarbons (16 PAHs), bisphenol A and alkylphenols, while synthetic steroids, myco-estrogens and phyto-estrogens were not detected. Determination of toxic-equivalent amounts showed that 28-96% of estrogenic activities in bioassays (0.2-6.3 ng/g 17beta-estradiol equivalents) were explained by 17beta-estradiol and estrone. PAHs were major contributors (20-60%) to the total dioxin-like activities. Interestingly, high PXR and (anti)AR activities were detected; however, the targeted analysed compounds could not explain the measured biological activities. This study highlighted the presence of multiple organic EDCs in French river sediments subjected to mixed diffuse pollution, and argues for the need to further identify AR and PXR active compounds in the aquatic environment
Boron and nitrogen codoping effect on transport properties of carbon nanotubes

International audienceThis paper reports a theoretical study of the effect of boron and nitrogen codoping on the transport properties of carbon nanotubes (CNTs) at the mesoscopic scale. A new tight-binding parametrization has been set up, based on density functional theory calculations, that enables a reliable description of the electronic structure of realistic BN-doped CNTs. With this model, we have carried out a deep analysis of the electronic mean free path (MFP) exhibited by these nanostructures. The MFP is highly sensitive to the geometry of the scattering centers. We report that the relative distance between B and N atoms in the network influences drastically the electronic conduction. Moreover, we point out that the scattering induced by small hexagonal BN domains in the carbon network is less important than the BN-pair case
Paired stable isotopes (O, C) and clumped isotope thermometry of magnesite and silica veins in the New Caledonia Peridotite Nappe

International audienceThe stable isotope compositions of veins provide information on the conditions of fluid-rock interaction and on the origin of fluids and temperatures. In New Caledonia, magnesite and silica veins occur throughout the Peridotite Nappe. In this work, we present stable isotope and clumped isotope data in order to constrain the conditions of fluid circulation and the relationship between fluid circulation and nickel ore-forming laterization focusing on the Koniambo Massif. For magnesite veins occurring at the base of the nappe, the high δ18O values between 27.8‰ and 29.5‰ attest to a low temperature formation. Clumped isotope analyses on magnesite give temperatures between 26°C and 42°C that are consistent with amorphous silica - magnesite oxygen isotope equilibrium. The meteoric origin of the fluid is indicated by calculated δ18Owater values between -3.4‰ to +1.5‰ Amorphous silica associated with magnesite or occurring in the coarse saprolite level displays a narrow range of δ18O values between 29.7‰ and 35.3‰. For quartz veins occurring at the top of the bedrock and at the saprolite level, commonly in association with Ni-talc-like minerals, the δ18O values are lower, between 21.8‰ and 29.0‰ and suggest low-temperature hydrothermal conditions (∼40-95°C). Thermal equilibration of the fluid along the geothermic gradient before upward flow through the nappe and/or influence of exothermic reactions of serpentinization could be the source(s) of heat needed to form quartz veins under such conditions