pinecone/core-2020-05-10-deduplication huggingface dataset:
Business impact and ROI : a proposed approach to learning and development investment

In increasing markets and economy, human capital investments have evolved as a result of intense competition, rapid growth and change, colliding cultures, technology waves and more, that occurs at unprecedented speeds. The interest and purpose of this research is due to Malaysian Government worries on Government Linked Companies (GLCs) and to assist the Malaysian Government as in the 9th Malaysian Plan, to focus on the National Mission to achieve Vision 2020 through one of the priority areas, human capital development. This paper draws on the review of training evaluation literature on the factors contributing to the implementation of evaluation on business impacts (BI) and ROI for soft skills training in Malaysian GLCs. The proposed contribution factors to be discussed are organisational policy, organisational resources and organisational culture
The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression.

The cerebral cavernous malformation (CCM) pathway is required in endothelial cells for normal cardiovascular development and to prevent postnatal vascular malformations, but its molecular effectors are not well defined. Here we show that loss of CCM signaling in endocardial cells results in mid-gestation heart failure associated with premature degradation of cardiac jelly. CCM deficiency dramatically alters endocardial and endothelial gene expression, including increased expression of the Klf2 and Klf4 transcription factors and the Adamts4 and Adamts5 proteases that degrade cardiac jelly. These changes in gene expression result from increased activity of MEKK3, a mitogen-activated protein kinase that binds CCM2 in endothelial cells. MEKK3 is both necessary and sufficient for expression of these genes, and partial loss of MEKK3 rescues cardiac defects in CCM-deficient embryos. These findings reveal a molecular mechanism by which CCM signaling controls endothelial gene expression during cardiovascular development that may also underlie CCM formation
Different answers to different questions. Exploring clinical decision making by general practitioners and psychiatrists about depressed patients

Contains fulltext :
                  129670.pdf (publisher's version ) (Open Access)Purpose: Exploring three perspectives on differences between general practitioners (GP) and psychiatrists in clinical decision making about depressed patients. The gold standard perspective focuses on differences in decisions (output) as a result of lack of expertise, the input perspective relates differences to different information use and to other roles, and the throughput perspective attributes differences to other information processing.
Methods: Twenty-six psychiatrists and 25 GPs gave their clinical judgment on four on-line vignettes of increasingly severely depressed patients. Supplementary information on 15 themes could be asked for by clicking on underlined phrases. Dependent variables were the amount and type of extra information used, time needed and judgments of the severity of symptoms, appropriate treatment and health care providers.
Results: Compared to psychiatrists, GPs were more reluctant to refer to specialized care, they needed less supplementary information and reached their conclusion in less time. Their processing of information appeared to be more contextual. Psychiatrists used a more stable procedure in which information inspection took place independently of differences in the vignettes.
Conclusions: GPs and psychiatrists not only give different answers (treatment advices) because they have different expertise, but also because they have different questions due to other roles, and they use different clinical decision procedures. Insight in these differences can be useful for ameliorating collaborative mental health care
Probabilistic true-concurrency models: Markov nets and a Law of large numbers

International audienceWe introduce the model of Markov nets, a probabilistic extension of safe Petri nets under the true-concurrency semantics. This means that traces, not firing sequences, are given a probability. This model builds upon our previous work on probabilistic event structures. We use the notion of branching cell for event structures and show that the latter provides the adequate notion of local state, for nets. We prove a Law of Large Numbers (LLN) for Markov nets, which constitutes the main contribution of the paper. This LLN allows characterizing in a quantitative way the asymptotic behavior of Markov nets
Characterization of lead-recycling facility emissions at various workplaces: Major insights for sanitary risks assessment

International audienceMost available studies on lead smelter emissions deal with the environmental impact of outdoor particles, but only a few focus on air quality at workplaces. The objective of this study is to physically and chemically characterize the Pb-rich particles emitted at different workplaces in a lead recycling plant. A multi-scale characterization was conducted from bulk analysis to the level of individual particles, to assess the particles properties in relation with Pb speciation and availability. Process PM from various origins were sampled and then compared; namely Furnace and Refining PM respectively present in the smelter and at refinery workplaces, Emissions PM present in channeled emissions. These particles first differed by their morphology and size distribution, with finer particles found in emissions. Differences observed in chemical composition could be explained by the industrial processes. All PM contained the same major phases (Pb, PbS, PbO, PbSO4 and PbO*PbSO4) but differed on the nature and amount of minor phases. Due to high content in PM, Pb concentrations in the CaCl2 extractant reached relatively high values (40 mg L−1). However, the ratios (soluble/total) of CaCl2 exchangeable Pb were relatively low (<0.02%) in comparison with Cd (up to 18%). These results highlight the interest to assess the soluble fractions of all metals (minor and major) and discuss both total metal concentrations and ratios for risk evaluations. In most cases metal extractability increased with decreasing size of particles, in particular, lead exchangeability was highest for channeled emissions. Such type of study could help in the choice of targeted sanitary protection procedures and for further toxicological investigations. In the present context, particular attention is given to Emissions and Furnace PM. Moreover, exposure to other metals than Pb should be considered
Synthesis, Structure and Electrochemical Behavior of New RPONOP (R = tBu, iPr) Pincer Complexes of the Fe2+, Co2+, Ni2+ and Zn2+ ions.

International audienceThe coordination chemistry of the M2+ ions of the first row elements iron, cobalt, nickel and zinc was explored with the ligands RPONOP (2,6-(R2PO)(C5H3N), R = iPr and tBu). Syntheses and characterization of the complexes Fe(RPONOP)Br2, Co(tBuPONOP)Cl2, Ni(RPONOP)I2 and Zn(RPONOP)I2 (R = tBu, iPr) are reported together with the crystal structures of Fe(RPONOP)Br2 (R = iPr and tBu), Co(tBuPONOP)Cl2, Co(iPrPONOP)Cl(m-Cl)CoCl2(THF), Ni(iPrPONOP)I2, Zn(iPrPONOP)I2 and of the oxidation product Zn[tBuP(=O)ONOP(=O)]I2 resulting from reaction with oxygen. The electrochemical behavior of the M(tBuPONOP)X2 complexes has been investigated in acetonitrile. While the nickel compound is stable, all the complexes are sensitive to dissociation of the RPONOP ligand or ligand scrambling in strongly coordinating media. Catalytic activity in formic acid dehydrogenation with TONs up to 1143 has been found for Ni(tBuPONOP)I2
CLASH-VLT: The mass, velocity-anisotropy, and          pseudo-phase-space density profiles of the z = 0.44 galaxy cluster MACS            J1206.2-0847

International audienceAims. We constrain the mass, velocity-anisotropy, and pseudo-phase-space          density profiles of the z = 0.44 CLASH cluster MACS J1206.2-0847, using the projected phase-space          distribution of cluster galaxies in combination with gravitational lensing.Methods. We use an unprecedented data-set of ≃600 redshifts for cluster          members, obtained as part of a VLT/VIMOS large program, to constrain the cluster mass          profile over the radial range ~0–5 Mpc (0–2.5 virial radii) using the MAMPOSSt and Caustic          methods. We then add external constraints from our previous gravitational lensing          analysis. We invert the Jeans equation to obtain the velocity-anisotropy profiles of          cluster members. With the mass-density and velocity-anisotropy profiles we then obtain the          first determination of a cluster pseudo-phase-space density profile.Results. The kinematics and lensing determinations of the cluster mass          profile are in excellent agreement. This is very well fitted by a NFW model with mass            M200 = (1.4 ± 0.2) × 1015 M⊙          and concentration c200 = 6 ± 1, only slightly higher than          theoretical expectations. Other mass profile models also provide acceptable fits to our          data, of (slightly) lower (Burkert, Hernquist, and Softened Isothermal Sphere) or          comparable (Einasto) quality than NFW. The velocity anisotropy profiles of the passive and          star-forming cluster members are similar, close to isotropic near the center and          increasingly radial outside. Passive cluster members follow extremely well the theoretical          expectations for the pseudo-phase-space density profile and the relation between the slope          of the mass-density profile and the velocity anisotropy. Star-forming cluster members show          marginal deviations from theoretical expectations.Conclusions. This is the most accurate determination of a cluster mass          profile out to a radius of 5 Mpc, and the only determination of the velocity-anisotropy          and pseudo-phase-space density profiles of both passive and star-forming galaxies for an          individual cluster. These profiles provide constraints on the dynamical history of the          cluster and its galaxies. Prospects for extending this analysis to a larger cluster sample          are discussed
Terrestrial and submarine evidence for the extent and timing of the Last Glacial Maximum and the onset of deglaciation on the maritime-Antarctic and sub-Antarctic islands

This paper is the maritime and sub Antarctic contribution to the Scientific Committee for Antarctic Research (SCAR) Past Antarctic Ice Sheet Dynamics (PAIS) community Antarctic Ice Sheet reconstruction. The overarching aim for all sectors of Antarctica was to reconstruct the Last Glacial Maximum (LGM) ice sheet extent and thickness, and map the subsequent deglaciation in a series of 5000 year time slices. However, our review of the literature found surprisingly few high quality chronological constraints on changing glacier extents on these timescales in the maritime and sub Antarctic sector. Therefore, in this paper we focus on an assessment of the terrestrial and offshore evidence for the LGM ice extent, establishing minimum ages for the onset of deglaciation, and separating evidence of deglaciation from LGM limits from those associated with later Holocene glacier fluctuations. Evidence included geomorphological descriptions of glacial landscapes, radiocarbon dated basal peat and lake sediment deposits, cosmogenic isotope ages of glacial features and molecular biological data. We propose a classification of the glacial history of the maritime and sub Antarctic islands based on this assembled evidence. These include: (Type I) islands which accumulated little or no LGM ice; (Type II) islands with a limited LGM ice extent but evidence of extensive earlier continental shelf glaciations; (Type III) seamounts and volcanoes unlikely to have accumulated significant LGM ice cover; (Type IV) islands on shallow shelves with both terrestrial and submarine evidence of LGM (and/or earlier) ice expansion; (Type V) Islands north of the Antarctic Polar Front with terrestrial evidence of LGM ice expansion; and (Type VI) islands with no data. Finally, we review the climatological and geomorphological settings that separate the glaciological history of the islands within this classification scheme
A search for prompt lepton-jets in pp collisions at √s=8 TeV with the ATLAS detector

A search is presented for a new, light boson with a mass of about 1 GeV and decaying promptly to jets of collimated electrons and/or muons (lepton-jets). The analysis is performed with 20.3 fb−1 of data collected by the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a centre-of-mass energy of 8 TeV. Events are required to contain at least two lepton-jets. This study finds no statistically significant deviation from predictions of the Standard Model and places 95% confidence-level upper limits on the contribution of new phenomena beyond the SM, incuding SUSY-portal and Higgs-portal models, on the number of events with lepton-jets
Liquid-crystal alignment on a-C : H films by nitrogen plasma beam scanning

[[abstract]]A plasma beam scanning treatment has been developed to modify the surface of the hydrogenated amorphous carbon (a-C:H) film on the indium tin oxide glass. The plasma beam scanning treatment makes the a-C:H film an excellent layer for liquid-crystal alignment. The qualities of a-C:H films were characterized by using atomic force microscope, micro-Raman spectroscopy, and field-emission scanning electron microscope. The ultrathin a-C:H films were deposited at 50% CH4/(H-2+CH4) gas ratio, 100 W radio-frequency power, and a gas pressure of 10 mtorr for 15 min by capacitive-coupled plasma chemical-vapor deposition method. The twist nematic cells were filled with liquid crystal (ZLI-2293) on the a-C:H film treated with different nitrogen plasma beam scanning time. The grooving mechanism is considered not responsible for the liquid-crystal (LC) alignment. Raman spectra suggest that a bond-breaking process of aromatic rings occurs in the a-C:H film. The O-1s, C-1s, and N-1s core-level spectra support that the nitrogen plasma beam scanning treatment induces a bond-breaking process of aromatic rings to create available carbon dangling bonds for the formation of C-O bonds. The newly formed C-O bonds are &quot;directional,&quot; which favor the LC alignment on the a-C:H film.[[fileno]]2010137010005[[department]]物理
Stable clustering, the halo model and non-linear cosmological power spectra.

We present the results of a large library of cosmological N-body simulations, using power-law initial spectra. The non-linear evolution of the matter power spectra is compared with the predictions of existing analytic scaling formulae based on the work of Hamilton et al. The scaling approach has assumed that highly non-linear structures obey 'stable clustering' and are frozen in proper coordinates. Our results show that, when transformed under the self-similarity scaling, the scale-free spectra define a non-linear locus that is clearly shallower than would be required under stable clustering. Furthermore, the small-scale non-linear power increases as both the power spectrum index n and the density parameter Ω decrease, and this evolution is not well accounted for by the previous scaling formulae. This breakdown of stable clustering can be understood as resulting from the modification of dark matter haloes by continuing mergers. These effects are naturally included in the analytic 'halo model' for non-linear structure; we use this approach to fit both our scale-free results and also our previous cold dark matter data. This method is more accurate than the commonly used Peacock–Dodds formula and should be applicable to more general power spectra. Code to evaluate non-linear power spectra using this method is available from http://as1.chem.nottingham.ac.uk/~res/software.html. Following publication, we will make the power-law simulation data publically available through the Virgo website http://www.mpa-garching.mpg.de/Virgo/
Characterization of novel podocyte proteins in the glomerular filtration barrier

The kidney is considered the most important organ of excretion eliminating the body
from metabolic waste products. The nephron is the functional unit of the kidney,
composed of a cluster of capillaries named glomerulus, and a tubular system. The blood
is filtered in the glomerular capillaries across the glomerular filtration barrier. The
barrier is an intricate biological structure composed of the inner capillary endothelial
cells, the glomerular basement membrane, and the podocytes. The podocyte is
phenotypically and functionally a sophisticated cell governed by a highly organized
cytoskeleton. Podocytes play a critical role in the initiation and progression of
proteinuric kidney diseases. The reorganization of podocyte cytoskeleton causing foot
process effacement is a key factor in the development of proteinuria. Better
understanding of the molecular composition and the biological interactions in these
cells is a necessity for future specific targeted therapies.



This study is based on a previous genome-wide approach aimed to characterize the
transcriptome of the renal glomerulus through large-scale sequencing and microarray
profiling. In reference to other well characterized podocyte-specific proteins, the
rationale was to identify and characterize novel podocyte-specific proteins that show a
similar restricted expression profile outside the glomerulus. In the papers, several such
proteins are described.



In paper I, sult1b1 was localized exclusively in the podocyte Golgi apparatus and
ankrd25 was localized to podocyte foot processes as shown by RT-PCR, Western
blotting and immunofluorescence stainings.



In Paper II, pdlim2 was localized to podocyte foot processes as shown by RT-PCR,
Western blotting, immunofluorescence and immunoelectron microscopy. In cultured
podocytes, pdlim2 seemed to regulate actin dynamics. In addition, using Coimmunoprecipitation
experiments, pdlim2 was shown to interact with α-actinin-4 and
amotl1. In semi-quantitative immunoelectron microscopy, there was a reduced
expression of pdlim2 in podocytes of patients with certain proteinuric renal diseases.



In Paper III: hip1, nfasc and olfml2a were localized exclusively in podocyte major
processes as shown with RT-PR, Western blotting, immunofluorescence stainings and
immunoelectron microscopy. During glomerulogenesis, the proteins were colocalized
with a major processes marker vimentin as shown by immunofluorescence double
stainings. The expression of hip1, olfml2a and pdlim2 was observed in glomerular
crescents indicating the presence of podocytes in these lesions.



In PaperIV, gprc5b was expressed exclusively by podocytes as shown with RTPCR,
Western blotting, immunofluorescence and immunoelectron microscopy. Gprc5b
knockdown in zebrafish exhibited classical features associated with loss of glomerular
function such as pericardial edema and dilated Bowman’s capsule. Thus, gprc5b is
essential for an intact glomerular filtration barrier
Search for high mass dilepton resonances in pp collisions at sqrt{s}=7 TeV with the ATLAS experiment

This Letter presents a search for high mass e(+)e(-) or mu(+)mu(-) resonances in pp collisions at root s = 7 TeV at the LHC. The data were recorded by the ATLAS experiment during 2010 and correspond to a total integrated luminosity of similar to 40 pb(-1). No statistically significant excess above the Standard Model expectation is observed in the search region of dilepton invariant mass above 110 GeV. Upper limits at the 95% confidence level are set on the cross section times branching ratio of Z' resonances decaying to dielectrons and dimuons as a function of the resonance mass. A lower mass limit of 1.048 TeV on the Sequential Standard Model Z' boson is derived, as well as mass limits on Z* and E(6)-motivated Z' models
Electrical conductivity studies of AgIAg 2 OB 2 O 3 TeO 2 gl

The silver ion conducting boro tellurite\ud
glasses have been prepared by melt quenching technique.\ud
The conductivity and dielectric measurements\ud
were carried out on these glasses as a function of\ud
frequency from 10 Hz to 10 MHz over a temperature\ud
range of 298–328 K. The analysis of conductivity\ud
measurement shows that the silver ions are the main\ud
charge carriers, which are considered to be the\ud
predominant factor playing the role of enhancing the\ud
conductivity. The power law exponent s and stretched\ud
exponent b are found to be insensitive to both\ud
temperature and compositions. AC conductivity and\ud
dielectric relaxation behaviour of these glasses were\ud
also studied and the results are discussed in view of the\ud
structure of borate and tellurite network
Search for new physics in events with high jet multiplicity and low
  missing transverse momentum in proton-proton collisions at sqrt(s) = 8 TeV

A dedicated search is presented for new phenomena in inclusive eight- and
ten-jet final states with low missing transverse momentum, with and without
identification of jets originating from b quarks. The analysis is based on data
from proton-proton collisions corresponding to an integrated luminosity of 19.6
inverse femtobarns collected with the CMS detector at the LHC at sqrt(s) = 8
TeV. The dominant multijet background expectations are obtained from low jet
multiplicity control samples. Data agree well with the standard model
background predictions, and limits are set in several benchmark models.
Colorons (axigluons) with masses between 0.6 and 0.75 (up to 1.15) TeV are
excluded at 95% confidence level. Similar exclusion limits for gluinos in
R-parity violating supersymmetric scenarios are from 0.6 up to 1.1 TeV. These
results comprise the first experimental probe of the coloron and axigluon
models in multijet final states.Comment: Replaced with the published version. Added the journal reference. All
  the figures and tables, including additional supplemental figures, can be
  found at
  http://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-13-001/index.htm
The kappa-(A)dS quantum algebra in (3+1) dimensions

The quantum duality principle is used to obtain explicitly the Poisson
analogue of the kappa-(A)dS quantum algebra in (3+1) dimensions as the
corresponding Poisson-Lie structure on the dual solvable Lie group. The
construction is fully performed in a kinematical basis and deformed Casimir
functions are also explicitly obtained. The cosmological constant $\Lambda$ is
included as a Poisson-Lie group contraction parameter, and the limit
$\Lambda\to 0$ leads to the well-known kappa-Poincar\'e algebra in the
bicrossproduct basis. A twisted version with Drinfel'd double structure of this
kappa-(A)dS deformation is sketched.Comment: 13 page