pinecone/core-2020-05-10-deduplication huggingface dataset:
A systematic review of generic multidimensional patient-reported outcome measures for children, part II: evaluation of psychometric performance of English-language versions in a general population

Journal ArticleResearch Support, Non-U.S. Gov'tReviewCopyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc.OBJECTIVES: The objectives of this systematic review were 1) to identify studies that assess the psychometric performance of the English-language version of 35 generic multidimensional patient-reported outcome measures (PROMs) for children and young people in general populations and evaluate their quality and 2) to summarize the psychometric properties of each PROM. METHODS: MEDLINE, EMBASE, and PsycINFO were searched. The methodological quality of the articles was assessed using the COnsensus-based Standards for selection of health Measurement INstruments checklist. For each PROM, extracted evidence of content validity, construct validity, internal consistency, test-retest reliability, proxy reliability, responsiveness, and precision was judged against standardized reference criteria. RESULTS: We found no evidence for 14 PROMs. For the remaining 21 PROMs, 90 studies were identified. The methodological quality of most studies was fair. Quality was generally rated higher in more recent studies. Not reporting how missing data were handled was the most common reason for downgrading the quality. None of the 21 PROMs has had all psychometric properties evaluated; data on construct validity and internal consistency were most frequently reported. CONCLUSIONS: Overall, consistent positive findings for at least five psychometric properties were found for Child Health and Illness Profile, Healthy Pathways, KIDSCREEN, and Multi-dimensional Student Life Satisfaction Scale. None of the PROMs had been evaluated for responsiveness to detect change in general populations. Further well-designed studies with transparent reporting of methods and results are required.(NIHR) Health Services and Delivery Research programme (Project 10/2002/16 http://www.nets.nihr.ac.uk/projects/hsdr/10200216).PenCLAHRCCerebr
Unitarity Challenges to the Randall Sundrum Model

We show that perturbative unitarity for $W_L^+ W_L^- \to W_L^+ W_L^-$ scattering places strong constraints on the Randall-Sundrum theory with two 3-branes, with matter confined to the TeV brane. The exchange of massive 4D Kaluza-Klein gravitons leads to amplitudes growing linearly with the CM energy squared. If the ratio $\mompl$ of the curvature of the metric to the 4D Planck mass is too small, the gravitational contributions lead to a violation of unitarity for energies below the TeV 4D cutoff, $\lphi$. The lower bound obtained by demanding unitarity up to $\sqrt s\sim \lphi$ can easily conflict with the $\mompl\lsim 0.1$ upper bound required for model consistency. Observation of the mass and width of one or more KK gravitons at the LHC will directly determine $\mompl$ and $\lphi$ and perturbative unitarity will then imply an upper energy limit for which the RS model is valid. This limit could be smaller than the value of $\lphi$ determined from the mass and width measurement
Continuum limit of the Volterra model, separation of variables and non standard realizations of the Virasoro Poisson bracket.

Latex, 43 pages Synchronized with the to be published versionThe classical Volterra model, equipped with the Faddeev-Takhtadjan Poisson bracket provides a lattice version of the Virasoro algebra. The Volterra model being integrable, we can express the dynamical variables in terms of the so called separated variables. Taking the continuum limit of these formulae, we obtain the Virasoro generators written as determinants of infinite matrices, the elements of which are constructed with a set of points lying on an infinite genus Riemann surface. The coordinates of these points are separated variables for an infinite set of Poisson commuting quantities including $L_0$. The scaling limit of the eigenvector can also be calculated explicitly, so that the associated Schroedinger equation is in fact exactly solvable
Search for direct top-squark pair production in final states with two leptons in pp collisions at root s=8 TeV with the ATLAS detector

A search is presented for direct top-squark pair production in final states with two leptons (electrons or muons) of opposite charge using 20.3 fb(-1) of pp collision data at root s = 8 TeV, collected by the ATLAS experiment at the Large Hadron Collider in 2012. No excess over the Standard Model expectation is found. The results are interpreted under the separate assumptions (i) that the top squark decays to a b-quark in addition to an on-shell chargino whose decay occurs via a real or virtual W boson, or (ii) that the top squark decays to a t-quark and the lightest neutralino. A top squark with a mass between 150 GeV and 445 GeV decaying to a b-quark and an on-shell chargino is excluded at 95% confidence level for a top squark mass equal to the chargino mass plus 10 GeV, in the case of a 1 GeV lightest neutralino. Top squarks with masses between 215 (90) GeV and 530 (170) GeV decaying to an on-shell (off-shell) t-quark and a neutralino are excluded at 95% confidence level for a 1 GeV neutralino
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.

N-methyl-D-aspartate receptors (NMDARs) are located in neuronal cell membranes at synaptic and extrasynaptic locations, where they are believed to mediate distinct physiological and pathological processes. Activation of NMDARs requires glutamate and a coagonist whose nature and impact on NMDAR physiology remain elusive. We report that synaptic and extrasynaptic NMDARs are gated by different endogenous coagonists, D-serine and glycine, respectively. The regionalized availability of the coagonists matches the preferential affinity of synaptic NMDARs for D-serine and extrasynaptic NMDARs for glycine. Furthermore, glycine and D-serine inhibit NMDAR surface trafficking in a subunit-dependent manner, which is likely to influence NMDARs subcellular location. Taking advantage of this coagonist segregation, we demonstrate that long-term potentiation and NMDA-induced neurotoxicity rely on synaptic NMDARs only. Conversely, long-term depression requires both synaptic and extrasynaptic receptors. Our observations provide key insights into the operating mode of NMDARs, emphasizing functional distinctions between synaptic and extrasynaptic NMDARs in brain physiology
Planck intermediate results: XXIII. Galactic plane emission components derived from Planck with ancillary data

Planck data when combined with ancillary data provide a unique opportunity to separate the diffuse emission components of the inner Galaxy. The purpose of the paper is to elucidate the morphology of the various emission components in the strong star-formation region lying inside the solar radius and to clarify the relationship between the various components. The region of the Galactic plane covered is l = 300° → 0° → 60° wherestar-formation is highest and the emission is strong enough to make meaningful component separation. The latitude widths in this longitude range lie between 1° and 2°, which correspond to FWHM z-widths of 100-200 pc at a typical distance of 6 kpc. The four emission components studied here are synchrotron, free-free, anomalous microwave emission (AME), and thermal (vibrational) dust emission. These components are identified by constructing spectral energy distributions (SEDs) at positions along the Galactic plane using the wide frequency coverage of Planck (28.4-857 GHz) in combination with low-frequency radio data at 0.408-2.3 GHz plus WMAP data at 23-94 GHz, along with far-infrared (FIR) data from COBE-DIRBE and IRAS. The free-free component is determined from radio recombination line (RRL) data. AME is found to be comparable in brightness to the free-free emission on the Galactic plane in the frequency range 20-40 GHz with a width in latitude similar to that of the thermal dust; it comprises 45 ± 1% of the total 28.4 GHz emission in the longitude range l = 300° → 0° → 60°. The free-free component is the narrowest, reflecting the fact that it is produced by current star-formation as traced by the narrow distribution of OB stars. It is the dominant emission on the plane between 60 and 100 GHz. RRLs from this ionized gas are used to assess its distance, leading to a free-free z-width of FWHM ≈ 100 pc. The narrow synchrotron component has a low-frequency brightness spectral index βsynch ≈ -2.7 that is similar to the broad synchrotron component indicating that they are both populated by the cosmic ray electrons of the same spectral index. The width of this narrow synchrotron component is significantly larger than that of the other three components, suggesting that it is generated in an assembly of older supernova remnants that have expanded to sizes of order 150 pc in 3 × 105 yr; pulsars of a similar age have a similar spread in latitude. The thermal dust is identified in the SEDs with average parameters of Tdust = 20.4 ± 0.4 K, βFIR = 1.94 ± 0.03 (> 353 GHz), and βmm = 1.67 ± 0.02 (< 353 GHz). The latitude distributions of gamma-rays, CO, and the emission in high-frequency Planck bands have similar widths, showing that they are all indicators of the total gaseous matter on the plane in the inner Galaxy
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents

The synthesis and characterization of a new class of DOTA 
(1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) 
monoamide-linked glycoconjugates (glucose, lactose and galactose) of 
different valencies (mono, di and tetra) and their Sm(III), Eu(III) and 
Gd(III) complexes are reported. The proton NMR spectrum of 
Eu(III)-DOTALac(III) shows the predominance of a single structural 
isomer of square antiprismatic geometry of the DOTA chelating moiety and

fast rotation about the amide bond connecting to the targeting 
glycodendrimer. The in vitro relaxivity of the Gd(III)-glycoconjugates 
was studied by proton nuclear magnetic relaxation dispersion (NMRD), 
yielding parameters close to those reported for other DOTA monoamides. 
The known recognition of sugars by lectins makes these glycoconjugates 
good candidates for medical imaging agents (MRI and gamma scintigraphy)
Search for H→γγ produced in association with top quarks and constraints on the Yukawa coupling between the top quark and the Higgs boson using data taken at 7 TeV and 8 TeV with the ATLAS detector

A search is performed for Higgs bosons produced in association with top quarks using the diphoton decay mode of the Higgs boson. Selection requirements are optimized separately for leptonic and fully hadronic final states from the top quark decays. The dataset used corresponds to an integrated luminosity of 4.5 fb−1 of proton--proton collisions at a center-of-mass energy of 7 TeV and 20.3 fb−1 at 8 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. No significant excess over the background prediction is observed and upper limits are set on the tt¯H production cross section. The observed exclusion upper limit at 95% confidence level is 6.7 times the predicted Standard Model cross section value. In addition, limits are set on the strength of the Yukawa coupling between the top quark and the Higgs boson, taking into account the dependence of the tt¯H and tH cross sections as well as the H→γγ branching fraction on the Yukawa coupling. Lower and upper limits at 95% confidence level are set at −1.3 and +8.0 times the Yukawa coupling strength in the Standard Model.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT and NSRF, Greece; ISF, MINERVA, GIF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW and NCN, Poland; GRICES and FCT, Portugal; MNE/IFA, Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America
Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells

Phagocytosis of apoptotic cells is a key step in the completion of programmed cell death that occurs throughout life in multicellular organisms. The molecular events involved in clearance of apoptotic cells are just beginning to be elucidated. Recently, CED-6, an adapter protein involved in engulfment has been cloned in Caenorhabditis elegans and in humans. CED-6 is composed of a phosphotyrosine-binding (PTB) domain and a proline-rich C-terminal domain with no apparent catalytic domain. Since PTB domains, originally identified in Shc, mediate intracellular signaling downstream of cell surface receptors, CED-6 has also been proposed to mediate intracellular signals leading to engulfment. In this report, we demonstrate that CED-6 dimerizes through a leucine zipper domain that is immediately adjacent to the PTB domain, Several lines of evidence based on co-immunoprecipitation studies, yeast two-hybrid assays, and gel filtration studies suggest that CED-B exists as a dimer in vivo. Through mutational analyses, we show that the leucine zipper is necessary and sufficient for CED-6 dimerization and that this dimerization is conserved among C. elegans, rodent, and human CED-6 proteins. We propose that dimerization may have unique implications for ligand binding via CED-6 and its function during the phagocytosis of apoptotic cells
The central region of spiral galaxies as seen by Herschel : M81, M99 and M100

With appropriate spatial resolution, images of spiral galaxies in thermal infrared (similar to 10 mu m and beyond) often reveal a bright central component, distinct from the stellar bulge, superimposed on a disk with prominent spiral arms. ISO and Spitzer studies have shown that much of the scatter in the mid-infrared colors of spiral galaxies is related to changes in the relative importance of these two components, rather than to other modifications, such as the morphological type or star formation rate, that affect the properties of the galaxy as a whole. With the Herschel imaging capability from 70 to 500 mu m, we revisit this two-component approach at longer wavelengths, to see if it still provides a working description of the brightness distribution of galaxies, and to determine its implications on the interpretation of global far-infrared properties of galaxies. We quantify the luminosity of the central component by both a decomposition of the radial surface brightness profile and a direct extraction in 2D. We find the central component contribution is variable within the three galaxies in our sample, possibly connected more directly to the presence of a bar than to the morphological type. The central component's relative contribution is at its maximum in the mid-infrared range and drops around 160 mu m to reach a constant value beyond 200 mu m. The central component contains a greater fraction of hot dust than the disk component, and while the colors of the central components are scattered, colors of the disk components are more homogenous from one galaxy to the next
Search for TeV-scale gravity signatures in high-mass final states with leptons and jets with the ATLAS detector at √s=13TeV

A search for physics beyond the Standard Model, in final states with at least one high transverse momentum charged lepton (electron or muon) and two additional high transverse momentum leptons or jets, is performed using 3.2 fb−1 of proton–proton collision data recorded by the ATLAS detector at the Large Hadron Collider in 2015 at View the MathML sources=13 TeV. The upper end of the distribution of the scalar sum of the transverse momenta of leptons and jets is sensitive to the production of high-mass objects. No excess of events beyond Standard Model predictions is observed. Exclusion limits are set for models of microscopic black holes with two to six extra dimensions
Untargeted Metabolomics in Doping Control: Detection of New Markers of Testosterone Misuse by Ultrahigh Performance Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

The use of untargeted metabolomics for the
discovery of markers is a promising and virtually unexplored
tool in the doping control field. Hybrid quadrupole time-of-
flight (QTOF) and hybrid quadrupole Orbitrap (Q Exactive)
mass spectrometers, coupled to ultrahigh pressure liquid
chromatography, are excellent tools for this purpose. In the
present work, QTOF and Q Exactive have been used to look
for markers for testosterone cypionate misuse by means of
untargeted metabolomics. Two different groups of urine
samples were analyzed, collected before and after the
intramuscular administration of testosterone cypionate. In
order to avoid analyte losses in the sample treatment, samples
were just 2-fold diluted with water and directly injected into
the chromatographic system. Samples were analyzed in both
positive and negative ionization modes. Data from both systems were treated under untargeted metabolomic strategies using
XCMS application and multivariate analysis. Results from the two mass spectrometers differed in the number of detected
features, but both led to the same potential marker for the particular testosterone ester misuse. The in-depth study of the MS and
MS/MS behavior of this marker allowed for the establishment of 1-cyclopentenoylglycine as a feasible structure. The putative
structure was confirmed by comparison with synthesized material. This potential marker seems to come from the metabolism of
the cypionic acid release after hydrolysis of the administered ester. Its suitability for doping control has been evaluated.Ministry of Education and Science, Spain: DEP2011-­‐28573-­‐C02-­‐01/02; WADA: project 14A29OP; Generalitat Valenciana: Prometeo/2009/054; PrometeoII/2014/023; ISIC EnviFood 2012/01
Pathogenesis of an emerging pathogen - Crimean-Congo Hemorrhagic Fever Virus

Epithelial cells represent the first barrier to viral infection and the site of viral entry and
release is often intimately connected with viral spread and pathogenesis. The plasma
membrane of epithelial cells is polarized into an apical and basolateral domain
separated by tight junctions (TJs). TJs also regulate paracellular permeability and can
cause leakage upon deregulation.
The key players underlying VHF pathogenesis are believed to be endothelial cells
(ECs) and immune cells. Generally ECs can be targeted either directly by viral
infection and/or indirectly by soluble mediators released from infected immune cells
leading to the observed hemorrhage and vascular permeability.
The main aims of this thesis were to study the direct and indirect effect of viral
replication on epithelial and immune cells as a possible contribution to CCHF
molecular pathogenesis.
By studying the site of entry and release in polarized epithelial cells, we showed the
entry and release of CCHFV to be preferentially basolateral. We studied the
transepithelial electrical resistance (TER) over infected epithelial cells, and showed that
CCHFV replication has no direct effect on epithelial permeability. Furthermore, we
observed no effect of CCHFV on the localization of the TJ proteins occludin and ZO-1
in epithelial cells. Interestingly, CCHFV directly activates ECs upon infection as shown
by upregulation of intercellular adhesion molecule 1 (ICAM-1), release of IL-6 and IL-
8 and most importantly increased adhesion of leukocytes.
The finding that the increased vascular permeability and hemorrhage is most likely not
caused by CCHFV induced TJ disassembly suggests that other cells are likely to be, at
least partly, involved in pathogenesis and we therefore focused on the contribution of
immune cells to pathogenesis. We showed that only monocyte-derived dendritic cells
(moDCs) could be productively infected by CCHFV and that infection was followed by
the release of tumor necrosis factor (TNF), IL-6 and IL-10. Interestingly, conditioned
media from CCHFV-infected moDCs activated ECs as indicated by enhanced
intercellular adhesion molecule 1 (ICAM-1) expression. This effect was shown to be
dependent on TNF.
The work presented in this thesis provides an insight into the direct and indirect
interplay between epithelial cells and immune cells and provides data that could be
used for further studies into the underlying mechanisms of CCHF pathogenesis.
Importantly understanding the mechanisms behind CCHF pathogenesis is most likely
needed for the future development of specific treatments and/or vaccines against
CCHFV
Measurement of the b-hadron production cross section using decays to D⁎+μ−X final states in pp collisions at √(s)=7 TeV with the ATLAS detector

The b-hadron production cross section is measured with the ATLAS detector in pp collisions at root s = 7 TeV, using 3.3 pb(-1) of integrated luminosity, collected during the 2010 LHC run. The b-hadrons are selected by partially reconstructing D*(+)mu X- final states. Differential cross sections are measured as functions of the transverse momentum and pseudorapidity. The measured production cross section for a b-hadron with p(T) > 9 GeV and vertical bar eta vertical bar < 2.5 is 32.7 +/- 0.8(stat.)(-6.8)(+4.5)(syst.) μb, higher than the next-to-leading-order QCD predictions but consistent within the experimental and theoretical uncertainties
Coherent gamma photon generation in a Bose-Einstein condensate of
  $^{135m}$Cs

We have identified a mechanism of collective nuclear de-excitation in a
Bose-Einstein condensate of $^{135}$Cs atoms in their isomeric states,
$^{135m}$Cs, suitable for the generation of coherent gamma photons. The process
described here does not correspond to single-pass amplification, which cannot
occur in atomic systems due to the large shift between absorption and emission
lines, nor does it require the large densities associated to standard Dicke
super-radiance. It thus overcome the limitations that have been hindering the
generation of coherent gamma rays in many systems. Therefore, we propose an
approach for generation of coherent gamma rays, which relies on a combination
of well established techniques of nuclear and atomic physics, and can be
realized with currently available technology.Comment: published in Physics Letters