pinecone/core-2020-05-10-deduplication huggingface dataset:
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

Background: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods: For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings: We pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and southeast Asia, south Asia, Oceania, and sub-Saharan Africa. In 2015, central and eastern Europe, sub-Saharan Africa, and south Asia had the highest blood pressure levels. Prevalence of raised blood pressure decreased in high-income and some middle-income countries; it remained unchanged elsewhere. The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries. The global increase in the number of adults with raised blood pressure is a net effect of increase due to population growth and ageing, and decrease due to declining age-specific prevalence. Interpretation: During the past four decades, the highest worldwide blood pressure levels have shifted from high-income countries to low-income countries in south Asia and sub-Saharan Africa due to opposite trends, while blood pressure has been persistently high in central and eastern Europe
The significance of land-atmosphere interactions in the Earth system — iLEAPS achievements and perspectives

The integrated land ecosystem-atmosphere processes study (iLEAPS) is an international research project focussing on the fundamental processes that link land-atmosphere exchange, climate, the water cycle, and tropospheric chemistry. The project, iLEAPS, was established 2004 within the International Geosphere-Biosphere Programme (IGBP). During its first decade, iLEAPS has proven to be a vital project, well equipped to build a community to address the challenges involved in understanding the complex Earth system: multidisciplinary, integrative approaches for both observations and modeling. The iLEAPS community has made major advances in process understanding, land-surface modeling, and observation techniques and networks. The modes of iLEAPS operation include elucidating specific iLEAPS scientific questions through networks of process studies, field campaigns, modeling, long-term integrated field studies, international interdisciplinary mega-campaigns, synthesis studies, databases, as well as conferences on specific scientific questions and synthesis meetings. Another essential component of iLEAPS is knowledge transfer and it also encourages community- and policy-related outreach activities associated with the regional integrative projects. As a result of its first decade of work, iLEAPS is now setting the agenda for its next phase (2014–2024) under the new international initiative, future Earth. Human influence has always been an important part of land-atmosphere science but in order to respond to the new challenges of global sustainability, closer ties with social science and economics groups will be necessary to produce realistic estimates of land use and anthropogenic emissions by analysing future population increase, migration patterns, food production allocation, land management practices, energy production, industrial development, and urbanization
High Oral Carriage of Non-albicans Candida spp. among HIV-Infected Individuals.

Non-albicans Candida (NAC) spp. in immunocompromised patients are linked to invasive infections with narrow treatment choice. This study aimed at comparing the oral colonization of NAC spp. between HIV and non-HIV infected individuals in Mwanza, Tanzania. Oral rinse of 351 HIV-infected and 639 non-HIV infected individuals were collected between March and July 2015. Phenotypic identifications of Candida spp. was done using Candida Chromogenic agar and confirmed by MALDI-TOF MS. NAC spp. were detected in 36/351 (10.3%) HIV-infected individuals compared to 28/639 (4.4%) of non-HIV infected individuals; P=0.0003. In HIV infected individuals, commonly isolated NAC spp. were Candida tropicalis, 10(2.8%), C. krusei (Issatschenki orientalis) 9(2.6%) and C. glabrata 8(2.3%). While for non-HIV infected individuals C. dubliniensis 8(1.3%) and C. tropicalis 5(0.9%) were commonly detected. As CD4 count/μl decreases by one unit the risk of being colonized by NAC spp. among HIV infected individuals increases by 1% (OR 1.01, 95% CI; 1.001-1.004, P=0.001).B The prevalence of NAC spp. is high among HIV-infected individuals with low CD4 count placing them at higher risk of invasive infections. Further studies to investigate the role of NAC spp. in causing invasive infections among immunocompromised patients are recommended
Micro-indentation based study on steel sheet degradation through forming and flattening: Toward a predictive model to assess cold recyclability

This paper was accepted for publication in the journal Materials & Design and the definitive published version is available at http://dx.doi.org/10.1016/j.matdes.2016.07.075.In Cold Roll Forming (CRF) process sheet material undergo a complex set of deformation that entail complicated through thickness residual deformation. This paper, focuses on material behaviour in CRF processes, with regarding damage and material degradation. A roll forming process is taken as case study and experimental investigation using extensive microhardness mapping alongside FE simulation of the process are the basis of material damage study. Indentation on different cross-sectional cutting angles -45, 0, 45 has been performed to study the sensitivity to orientation and crystallographic texture. A 3D Finite Element simulation with emphasis on through-thickness variation of the plastic deformation was carried out, using multiple layers of solid elements representing the sheet. A smart approach to reduce computational cost was employed in MSC.Marc by implementing simulation of a master model of complete material with shell elements, followed by partial sub-modelling comprising solid elements in regions of interest. This cross-sectional hardness map was then converted to the corresponding equivalent plastic strain in the cross section for validation. The correlation factor between Hardness and yield stress was discussed
SEARCHES FOR LARGE-SCALE ANISOTROPY IN THE ARRIVAL DIRECTIONS OF COSMIC RAYS DETECTED ABOVE ENERGY OF 10(19) eV AT THE PIERRE AUGER OBSERVATORY AND THE TELESCOPE ARRAY

Spherical harmonic moments are well-suited for capturing anisotropy at any scale in the flux of cosmic rays. An unambiguous measurement of the full set of spherical harmonic coefficients requires full-sky coverage. This can be achieved by combining data from observatories located in both the northern and southern hemispheres. To this end, a joint analysis using data recorded at the Telescope Array and the Pierre Auger Observatory above 10(19) eV is presented in this work. The resulting multipolar expansion of the flux of cosmic rays allows us to perform a series of anisotropy searches, and in particular to report on the angular power spectrum of cosmic rays above 10(19) eV. No significant deviation from isotropic expectations is found throughout the analyses performed. Upper limits on the amplitudes of the dipole and quadrupole moments are derived as a function of the direction in the sky, varying between 7% and 13% for the dipole and between 7% and 10% for a symmetric quadrupole.open
The globular cluster system of NGC 1316: Wide-field photometry in the Washington system

Context: NGC 1316 (Fornax A) is a prominent merger remnant in the outskirts of the Fornax cluster. The bulge stellar population of NGC 1316 has a strong intermediate-age component. Studies of its globular cluster system may help to further refine its probably complex star formation history. 
Aims: The cluster system has not yet been studied in its entirety. We therefore present a wide-field study of the globular cluster system of NGC 1316, investigating its properties in relation to the global morphology of NGC 1316. 
Methods: We used the MOSAIC II camera at the 4-m Blanco telescope at CTIO in the filters Washington C and Harris R. We identified globular cluster candidates and studied their color distribution and the structural properties of the system. In an appendix, we also remark on the morphology, present color maps, and present new models for the brightness and color profiles of the galaxy. 
Results: The cluster system is well confined to the optically visible outer contours of NGC 1316. There are about 640 cluster candidates down to R = 24 mag. The color distribution of the entire sample is unimodal, but the color distribution of bright subsamples in the bulge shows two peaks that, compared with theoretical Washington colors with solar metallicity, correspond to ages of about 2 Gyr and 0.8 Gyr, respectively. We also find a significant population of clusters in the color range 0.8 < C − R < 1.1, which must be populated by clusters younger than 0.8 Gyr, unless they are very metal-poor. The color interval 1.3 < C − R < 1.6 hosts the bulk of intermediate-age clusters, which show a surface density profile with a sharp decline at about 4 . The outer cluster population shows an unimodal color distribution with a peak at C − R = 1.1, indicating a higher contribution of old, metal-poor clusters. However, their luminosity function does not show the expected turn-over, so the fraction of younger clusters is still significant. We find a pronounced concentration of blue cluster candidates in the area of Schweizer’s L1-structure. 
Conclusions:. Cluster formation in NGC 1316 has continued after an initial burst that is presumably related to the main merger. A toy model with two bursts of ages 2 Gyr and 0.8 Gyr is consistent with photometric properties and dynamical M/L-values. In this model, the older, metal-rich pre-merger population has an age of 7 Gyr, contributes 90% of the bulge mass and 70% of the luminosity. Its properties are consistent with spiral galaxies, where star-bursts were triggered by major/minor mergers and/or close encounters.Fil: Richtler, T.. Universidad de Concepción; ChileFil: Bassino, Lilia Patricia. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Astrofísica de La Plata; ArgentinaFil: Dirsch, B.. Friedrich-Ebert-Gymnasium; AlemaniaFil: Kumar, B.. Aryabhatta Research Institute of Observational Sciences; Indi
A planetary system with gas giants and super-Earths around the nearby M dwarf GJ676A :
                    Optimizing data analysis techniques for the detection of multi-planetary systems

G. Anglada-Escude and M. Tuomi, 'A planetary system via gas giants and super-Earths around the nearby M dwarf GJ 676A: Optimizing data analysis techniques for the detection of multi-planetary systems', Astronomy & Astrophysics, Vol. 548, A58 (2012). The version of record is available online at DOI: 10.1051/0004-6361/201219910 ?? ESO 2012 Published by EDP SciencesContext. Several M dwarfs are targets of systematical monitoring in searches for Doppler signals caused by low-mass exoplanet companions. As a result, an emerging population of high-multiplicity planetary systems around low-mass stars are being detected as well. Aims. We optimize classic data analysis methods and develop new ones to enhance the sensitivity towards lower amplitude planets in high-multiplicity systems. We apply these methods to the public HARPS observations of GJ????? 676A, a nearby and relatively quiet M dwarf with one reported gas giant companion. Methods. We rederived Doppler measurements from public HARPS spectra using the recently developed template matching method (HARPS-TERRA software). We used refined versions of periodograms to assess the presence of additional low-mass companions. We also analysed the same dataset with Bayesian statistics tools and compared the performance of both approaches. Results. We confirm the already reported massive gas giant candidate and a long period trend in the Doppler measurements. In addition to that, we find very secure evidence in favour of two new candidates in close-in orbits and masses in the super-Earth mass regime. Also, the increased time-span of the observations allows the detection of curvature in the long-period trend. suggesting the presence of a massive outer companion whose nature is still unclear. Conclusions. Despite the increased sensitivity of our new periodogram tools, we find that Bayesian methods are significantly more sensitive and reliable in the early detection of candidate signals, but more work is needed to quantify their robustness against false positives. While hardware development is important in increasing the Doppler precision, development of data analysis techniques can help to reveal new results from existing data sets with significantly fewer resources. This new system holds the record of minimum-mass range (from Msini ~ 4.5 M??????? to 5 Mjup) and period range (from P ~ 3.6 days to more than 10 years). Although all planet candidates are substantially more massive, it is the first exoplanetary system with a general architecture similar to our solar system. GJ 676A can be happily added to the family of high-multiplicity planetary systems around M dwarfs
In good company: The influence of peers on industry engagement by academic scientists

AbstractPrevious research on academic entrepreneurship and engagement with industry has found that the behaviour of academics is influenced by their local social context. However, we know little about the mechanisms that produce this effect. We argue that academic scientists’ industry engagement is influenced significantly by the behaviour of their peers, that is, the behaviour of colleagues of similar seniority. Using insights from social psychology, we hypothesize that these peer effects are produced by the mechanism of social comparison. In an analysis of data from multiple sources for 1370 UK academic scientists and engineers, we find that peer effects are stronger for early career individuals and weaker for star scientists, suggesting the incidence of social comparison. We argue that individuals look to their immediate peers for inspiration, because they view them as an important reference group and use them as a benchmark for their own ambitions and behaviours. Our findings have important implications for how universities may encourage scientists’ behaviours by paying attention to local work contexts
The Hankel transform of first- and second-order tensor fields: definition and use for modeling circularly symmetric leaky waveguides

AbstractA tensor Hankel transform (THT) is defined for vector fields, such as displacement, and second-order tensor fields, such as stress or strain. The THT establishes a bijection between the real space and the wave-vector domain, and, remarkably, cannot be reduced to a scalar transform applied separately to each component.One of the advantages of this approach is that some standard elasticity problems can be concisely rewritten by applying this tensor integral transform coupled with an azimuthal Fourier series expansion. A simple and compact formulation of the boundary conditions is also achieved.Thanks to the THT, we obtain for each azimuthal wavenumber and each azimuthal direction exactly the same wave equation as for a standard 2D model of elastic wave propagation. Thus, waves similar to the standard plane P, SV and SH waves are naturally found.Lastly, the THT is used to calculate the ultrasonic field in an isotropic cylindrical leaky waveguide, the walls of which radiating into a surrounding elastic medium, by using a standard scattering approach
Beyond Compulsory Schooling: Resilience and Academic Success of Immigrant Youth

AbstractThe present study examines the relationship between resilience and school completion of immigrant youth in Spain. Ninety- four students in their fourth year compulsory education participated in the study; they were from 19 different nationalities, between 15 and 18 years of age, and the ratio boys/girls was 55/45. There were no significant differences by gender, age, residence time, or incorporation into the education system. Differences were associated to cultural groups and variables related with academic self-perception. Finally, it was shown that young students that continue their studies beyond obligatory education have higher levels of resilience, as measured by the SV-RES scale. Overall, the findings in this study suggest the activation of the relational dimension of “social capital” in youth, as for example through mentoring or service-learning programs
Different answers to different questions Exploring clinical decision making by general practitioners and psychiatrists about depressed patients

AbstractPurposeExploring three perspectives on differences between general practitioners (GP) and psychiatrists in clinical decision making about depressed patients. The gold standard perspective focuses on differences in decisions (output) as a result of lack of expertise, the input perspective relates differences to different information use and to other roles, and the throughput perspective attributes differences to other information processing.MethodsTwenty-six psychiatrists and 25 GPs gave their clinical judgment on four on-line vignettes of increasingly severely depressed patients. Supplementary information on 15 themes could be asked for by clicking on underlined phrases. Dependent variables were the amount and type of extra information used, time needed and judgments of the severity of symptoms, appropriate treatment and health care providers.ResultsCompared to psychiatrists, GPs were more reluctant to refer to specialized care, they needed less supplementary information and reached their conclusion in less time. Their processing of information appeared to be more contextual. Psychiatrists used a more stable procedure in which information inspection took place independently of differences in the vignettes.ConclusionsGPs and psychiatrists not only give different answers (treatment advices) because they have different expertise, but also because they have different questions due to other roles, and they use different clinical decision procedures. Insight in these differences can be useful for ameliorating collaborative mental health care
The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8+ T-cell responses: The immunological consequences of the biodistribution profile

AbstractA prerequisite for vaccine-mediated induction of CD8+ T-cell responses is the targeting of dendritic cell (DC) subsets specifically capable of cross-presenting antigen epitopes to CD8+ T cells. Administration of a number of cationic adjuvants via the intraperitoneal (i.p.) route has been shown to result in strong CD8+ T-cell responses, whereas immunization via e.g. the intramuscular (i.m.) or subcutaneous (s.c.) routes often stimulate weak CD8+ T-cell responses. The hypothesis for this is that self-drainage of the adjuvant/antigen to the lymphoid organs, which takes place upon i.p. immunization, is required for the subsequent activation of cross-presenting lymphoid organ-resident CD8α+ DCs. In contrast, s.c. or i.m. immunization usually results in the formation of a depot at the site of injection (SOI), which hinders the self-drainage and targeting of the vaccine to cross-presenting CD8α+ DCs. We investigated this hypothesis by correlating the biodistribution pattern and the adjuvanticity of the strong CD8+ T-cell inducing liposomal cationic adjuvant formulation 09 (CAF09), which is composed of dimethyldioctadecylammonium bromide/monomycoloyl glycerol liposomes with polyinosinic:polycytidylic acid electrostatically adsorbed to the surface. Biodistribution studies with radiolabeled CAF09 and a surface-adsorbed model antigen [ovalbumin (OVA)] showed that a significantly larger fraction of the vaccine dose localized in the draining lymph nodes (dLNs) and the spleen 6h after i.p. immunization, as compared to after i.m. immunization. Studies with fluorescently labelled OVA+CAF09 demonstrated a preferential association of OVA+CAF09 to DCs/monocytes, as compared to macrophages and B cells, following i.p. immunization. Administration of OVA+CAF09 via the i.p. route did also result in DC activation, whereas no DC activation could be measured within the same period with unadjuvanted OVA and OVA+CAF09 administered via the s.c. or i.m. routes. In the dLNs, the highest level of activated, cross-presenting CD8α+ DCs was detected at 24h post immunization, whereas an influx of activated, migrating and cross-presenting CD103+ DCs to the dLNs could be measured after 48h. This suggests that the CD8α+ DCs are activated by self-draining OVA+CAF09 in the lymphoid organs, whereas the CD103+ DCs are stimulated by the OVA+CAF09 at the SOI. These results support the hypothesis that the self-drainage of OVA+CAF09 to the draining LNs is required for the activation of CD8α+ DCs, while the migratory CD103+ DCs may play a role in sustaining the subsequent induction of strong CD8+ T-cell responses
Hypoglycemia-Activated GLUT2 Neurons of the Nucleus Tractus Solitarius Stimulate Vagal Activity and Glucagon Secretion

SummaryGlucose-sensing neurons in the brainstem participate in the regulation of energy homeostasis but have been poorly characterized because of the lack of specific markers to identify them. Here we show that GLUT2-expressing neurons of the nucleus of the tractus solitarius form a distinct population of hypoglycemia-activated neurons. Their response to low glucose is mediated by reduced intracellular glucose metabolism, increased AMP-activated protein kinase activity, and closure of leak K+ channels. These are GABAergic neurons that send projections to the vagal motor nucleus. Light-induced stimulation of channelrhodospin-expressing GLUT2 neurons in vivo led to increased parasympathetic nerve firing and glucagon secretion. Thus GLUT2 neurons of the nucleus tractus solitarius link hypoglycemia detection to counterregulatory response. These results may help identify the cause of hypoglycemia-associated autonomic failure, a major threat in the insulin treatment of diabetes