pinecone/core-2020-05-10-deduplication huggingface dataset:
Long term underwater sound measurements in the shipping noise indicator bands 63 Hz and 125 Hz from the port of Falmouth Bay, UK

Chronic low frequency anthropogenic sound, such as shipping noise, may be negatively affecting marine life. The EU’s Marine Strategy Framework Directive (MSFD) includes a specific indicator focused on this noise. This indicator is the yearly average sound level in third-octave bands with centre frequencies at 63 Hz and 125 Hz. These levels are described for Falmouth Bay, UK, an active port at the entrance to the English Channel. Underwater sound was recorded for 30 min. h-1 over the period June 2012 to November 2013 for a total of 435 days. Mean third-octave levels were louder in the 125-Hz band (annual mean level of 96.0 dB re 1 μPa) than in the 63-Hz band (92.6 dB re 1 μPa). These levels and variations are assessed as a function of seasons, shipping activity and wave height, providing comparison points for future monitoring activities, including the MSFD and emerging international regulation
Exploiting human and mouse transcriptomic data: Identification of circadiangenes and pathways influencing health

The power of the application of bioinformatics across multiplepublicly available transcriptomic data sets was explored. Using 19 human and mouse circadian transcriptomic data sets, we found that NR1D1 and NR1D2 which encode heme- responsive nuclear receptors are the most rhythmic tran- scripts across sleep conditions and tissues suggesting that they are at the core of circadian rhythm generation. Analyzes of human transcriptomic data show that a core set of transcripts related to processes including immune function, glucocorticoid signalling, and lipid metabolism is rhythmically expressed independently of the sleep-wake cycle. We also identify key transcripts associated with transcription and translation that are disrupted by sleep manipulations, and through network analysis identify putative mechanisms underlying the adverse health outcomes associated with sleep disruption, such as diabetes and cancer. Comparative bioinformatics applied toexisting and future data sets will be a powerful tool for the identification of core circadian- andsleep-dependent molecules
Galactic cold cores VI. Dust opacity spectral index

The Galactic Cold Cores project has made Herschel observations of 116 fields
where the Planck survey has found signs of cold dust emission. The fields
contain sources in different environments and different phases of star
formation. The dust opacity spectral index beta and the dust colour temperature
T are derived using Herschel and Planck data. The relation between beta and T
is examined for the whole sample and inside individual fields. Based on IRAS
and Planck data, the fields are characterised by a median colour temperature of
16.1 K and a median opacity spectral index of beta=1.84. We observe a clear
T-beta anti-correlation. In Herschel observations, constrained at lower
resolution by Planck data, the variations follow the column density structure
and beta(FIR) can rise to ~2.2 in individual clumps. The Planck 217 GHz band
shows a systematic excess that is consistent with a general flattening of the
dust emission spectrum at millimetre wavelengths. When fitted separately below
and above 700 um, the median spectral index values are beta(FIR) ~ 1.91 and
beta(mm) ~ 1.66. The spectral index changes as a function of column density and
wavelength. Beta variations are partly masked by temperature gradients and the
changes in the intrinsic grain properties may be even greater.Comment: Accepted to A&A, 138 page
A versatile dual-species Zeeman slower for caesium and ytterbium

We describe the design, construction and operation of a versatile
dual-species Zeeman slower for both Cs and Yb, which is easily adaptable for
use with other alkali metals and alkaline earths. With the aid of analytic
models and numerical simulation of decelerator action, we highlight several
real-world problems affecting the performance of a slower and discuss effective
solutions. To capture Yb into a magneto-optical trap (MOT), we use the broad
$^1S_0$ to $^1P_1$ transition at 399 nm for the slower and the narrow $^1S_0$
to $^3P_1$ intercombination line at 556 nm for the MOT. The Cs MOT and slower
both use the D2 line ($6^2S_{1/2}$ to $6^2P_{3/2}$) at 852 nm. We demonstrate
that within a few seconds the Zeeman slower loads more than $10^9$ Yb atoms and
$10^8$ Cs atoms into their respective MOTs. These are ideal starting numbers
for further experiments on ultracold mixtures and molecules.Comment: 15 pages, 15 figures, 4 tables, revtex4-
Bethe-Salpeter bound-state structure in Minkowski space

The quantitative investigation of the scalar Bethe-Salpeter equation in
Minkowski space, within the ladder-approximation framework, is extended to
include the excited states. This study has been carried out for an interacting
system composed by two massive bosons exchanging a massive scalar, by adopting
(i) the Nakanishi integral representation of the Bethe-Salpeter amplitude, and
(ii) the formally exact projection onto the null plane. Our analysis, on one
hand, confirms the reliability of the method already applied to the ground
state and, on the other one, extends the investigation from the valence
distribution in momentum space to the corresponding quantity in the
impact-parameter space, pointing out some relevant features, like (i) the
equivalence between Minkowski and Euclidean transverse-momentum amplitudes, and
(ii) the leading exponential fall-off of the valence wave function in the
impact-parameter space.Comment: 15 pages, 7 figure
Higher harmonic flow coefficients of identified hadrons in Pb-Pb
  collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV

The elliptic, triangular, quadrangular and pentagonal anisotropic flow
coefficients for $\pi^{\pm}$, $\mathrm{K}^{\pm}$ and p+$\overline{\mathrm{p}}$
in Pb-Pb collisions at $\sqrt{s_\mathrm{{NN}}} = 2.76$ TeV were measured with
the ALICE detector at the Large Hadron Collider. The results were obtained with
the Scalar Product method, correlating the identified hadrons with reference
particles from a different pseudorapidity region. Effects not related to the
common event symmetry planes (non-flow) were estimated using correlations in pp
collisions and were subtracted from the measurement. The obtained flow
coefficients exhibit a clear mass ordering for transverse momentum
($p_{\mathrm{T}}$) values below $\approx$ 3 GeV/$c$. In the intermediate
$p_{\mathrm{T}}$ region ($3 < p_{\mathrm{T}} < 6$ GeV/$c$), particles group at
an approximate level according to the number of constituent quarks, suggesting
that coalescence might be the relevant particle production mechanism in this
region. The results for $p_{\mathrm{T}} < 3$ GeV/$c$ are described fairly well
by a hydrodynamical model (iEBE-VISHNU) that uses initial conditions generated
by A Multi-Phase Transport model (AMPT) and describes the expansion of the
fireball using a value of 0.08 for the ratio of shear viscosity to entropy
density ($\eta/s$), coupled to a hadronic cascade model (UrQMD). Finally,
expectations from AMPT alone fail to quantitatively describe the measurements
for all harmonics throughout the measured transverse momentum region. However,
the comparison to the AMPT model highlights the importance of the late hadronic
rescattering stage to the development of the observed mass ordering at low
values of $p_{\mathrm{T}}$ and of coalescence as a particle production
mechanism for the particle type grouping at intermediate values of
$p_{\mathrm{T}}$ for all harmonics.Comment: 40 pages, 22 captioned figures (7 in app A), 2 tables, authors from
  page 35, published version, figures at
  http://aliceinfo.cern.ch/ArtSubmission/node/290
Associated production of a top pair and a W boson at
  next-to-next-to-leading logarithmic accuracy

We consider soft gluon emission corrections to the production of a
top-antitop pair in association with a W boson at the Large Hadron Collider. We
obtain a soft-gluon resummation formula for this production process which is
valid up to next-to-next-to-leading logarithmic accuracy. We evaluate the soft
gluon resummation formula in Mellin space by means of an in-house parton level
Monte Carlo code which allows us to obtain predictions for the total cross
section as well as for several differential distributions. We study the impact
of the soft-gluon resummation corrections in comparison to fixed order
calculations.Comment: 31 pages, 8 figures and 5 table
A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II

Crigler-Najjar (CN) disease is caused by a deficiency of the hepatic enzyme, bilirubin UDP-glucuronosyltransferase (B-UGT). We have found two CN type II patients, who were homozygous for a leucine to arginine transition at position 15 of B-UGT1. This mutation is expected to disrupt the hydrophobic core of the signal peptide of B-UGT1. Wild type and mutant B-UGT cDNAs were transfected in COS cells. Mutant and wild type mRNA were formed in equal amounts. The mutant protein was expressed with 0.5% efficiency, as compared to wild type. Mutant and wild type mRNAs were translated in vitro. Wild type transferase is processed by microsomes, no processing of the mutant protein was observed
A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizonts.

Intracellular schizonts of the apicomplexans Theileria annulata and Theileria parva immortalize bovine leucocytes thereby causing fatal immunoproliferative diseases. Buparvaquone, a hydroxynaphthoquinone related to parvaquone, is the only drug available against Theileria. The drug is only effective at the onset of infection and emerging resistance underlines the need for identifying alternative compounds. Current drug assays employ monitoring of proliferation of infected cells, with apoptosis of the infected host cell as a read-out, but it is often unclear whether active compounds directly impair the viability of the parasite or primarily induce host cell death. We here report on the development of a quantitative reverse transcriptase real time PCR method based on two Theileria genes, tasp and tap104, which are both expressed in schizonts. Upon in vitro treatment of T. annulata infected bovine monocytes with buparvaquone, TaSP and Tap104 mRNA expression levels significantly decreased in relation to host cell actin already within 4 h of drug exposure, while significant differences in host cell proliferation were detectable only after 48-72 h. TEM revealed marked alterations of the schizont ultrastructure already after 2 h of buparvaquone treatment, while the host cell remained unaffected. Expression of TaSP and Tap104 proteins showed a marked decrease only after 24 h. Therefore, the analysis of expression levels of mRNA coding for TaSP and Tap104 allows to directly measuring impairment of parasite viability. We subsequently applied this method using a series of compounds affecting different targets in other apicomplexan parasites, and show that monitoring of TaSP- and Tap104 mRNA levels constitutes a suitable tool for anti-theilerial drug development
An algebraic framework for Diffie–Hellman assumptions

We put forward a new algebraic framework to generalize and analyze Diffie-Hellman like Decisional Assumptions which allows us to argue about security and applications by considering only algebraic properties. Our D`,k-MDDH assumption states that it is hard to decide whether a vector in ¿ìs linearly dependent of the columns of some matrix in ¿`×k sampled according to distribution D`,k. It covers known assumptions such as DDH, 2-Lin (linear assumption), and k-Lin (the k-linear assumption). Using our algebraic viewpoint, we can relate the generic hardness of our assumptions in m-linear groups to the irreducibility of certain polynomials which describe the output of D`,k. We use the hardness results to find new distributions for which the D`,k-MDDH-Assumption holds generically in m-linear groups. In particular, our new assumptions 2-SCasc and 2-ILin are generically hard in bilinear groups and, compared to 2-Lin, have shorter description size, which is a relevant parameter for efficiency in many applications. These results support using our new assumptions as natural replacements for the 2-Lin Assumption which was already used in a large number of applications. To illustrate the conceptual advantages of our algebraic framework, we construct several fundamental primitives based on any MDDH-Assumption. In particular, we can give many instantiations of a primitive in a compact way, including public-key encryption, hash-proof systems, pseudo-random functions, and Groth-Sahai NIZK and NIWI proofs. As an independent contribution we give more efficient NIZK and NIWI proofs for membership in a subgroup of ¿` . The results imply very significant efficiency improvements for a large number of schemes.Peer ReviewedPostprint (author's final draft
Myeloma bone disease: Pathophysiology and management.

Multiple myeloma bone disease is marked by severe dysfunction of both bone formation and resorption and serves as a model for understanding the regulation of osteoblasts (OBL) and osteoclasts (OCL) in cancer. Myeloma bone lesions are purely osteolytic and are associated with severe and debilitating bone pain, pathologic fractures, hypercalcemia, and spinal cord compression, as well as increased mortality. Interactions within the bone marrow microenvironment in myeloma are responsible for the abnormal bone remodeling in myeloma bone disease. Myeloma cells drive bone destruction that increases tumor growth, directly stimulates the OCL formation, and induces cells in the marrow microenvironment to produce factors that drive OCL formation and suppress OBL formation. Factors produced by marrow stromal cells and OCL promote tumor growth through direct action on myeloma cells and by increasing angiogenesis. Current therapies targeting MMBD focus on preventing osteoclastic bone destruction; however regulators of OBL inhibition in MMBD have also been identified, and targeted agents with a potential anabolic effect in MMBD are under investigation. This review will discuss the mechanisms responsible for MMBD and therapeutic approaches currently in use and in development for the management of MMBD
Monotonic Extensions of Petri Nets: Forward and Backward Search Revisited

In this paper, we revisit the forward and backward approaches to the verification of extensions of infinite state Petri Nets. As contributions, we propose an efficient data structure to represent infinite downward closed sets of markings and to compute symbolically the minimal coverability set of Petri Nets, we identify a subclass of Transfer Nets for which the forward approach generalizes and we propose a general strategy to use both the forward and the backward approach for the efficient verification of general Transfer Nets
Probabilistic maturation reaction norms assessed from mark- recaptures of wild fish in their natural habitat

Reaction norms are a valuable tool in evolutionary biology. Lately, the probabilistic maturation reaction norm approach, describing probabilities of maturing at combinations of age and body size, has been much applied for testing whether phenotypic changes in exploited populations of fish are mainly plastic or involving an evolutionary component. However, due to typical field data limitations, with imperfect knowledge about individual life histories, this demographic method still needs to be assessed. Using 13years of direct mark-recapture observations on individual growth and maturation in an intensively sampled population of brown trout (Salmo trutta), we show that the probabilistic maturation reaction norm approach may perform well even if the assumption of equal survival of juvenile and maturing fish does not hold. Earlier studies have pointed out that growth effects may confound the interpretation of shifts in maturation reaction norms, because this method in its basic form deals with body size rather than growth. In our case, however, we found that juvenile body size, rather than annual growth, was more strongly associated with maturation. Viewed against earlier studies, our results also underscore the challenges of generalizing life-history patterns among species and populations
Comprehensive Analysis of Market Conditions in the Foreign Exchange
  Market: Fluctuation Scaling and Variance-Covariance Matrix

We investigate quotation and transaction activities in the foreign exchange
market for every week during the period of June 2007 to December 2010. A
scaling relationship between the mean values of number of quotations (or number
of transactions) for various currency pairs and the corresponding standard
deviations holds for a majority of the weeks. However, the scaling breaks in
some time intervals, which is related to the emergence of market shocks. There
is a monotonous relationship between values of scaling indices and global
averages of currency pair cross-correlations when both quantities are observed
for various window lengths $\Delta t$.Comment: 13 pages, 10 figure
Evidence for the associated production of a W boson and a top quark in
  ATLAS at sqrt(s) = 7 TeV

This letter presents evidence for the associated production of a W boson and
a top quark using 2.05 fb^-1 of pp collision data at sqrt(s) = 7 TeV
accumulated with the ATLAS detector at the LHC. The analysis is based on the
selection of the dileptonic final states with events featuring two isolated
leptons, electron or muon, with significant transverse missing momentum and at
least one jet. An approach based on boosted decision trees has been developed
to improve the discrimination of single top-quark Wt events from background. A
template fit to the final classifier distributions is performed to determine
the cross-section. The result is incompatible with the background-only
hypothesis at the 3.3 sigma level, the expected sensitivity assuming the
Standard Model production rate being 3.4 sigma. The corresponding cross-section
is determined and found to be sigma_Wt = 16.8 +/- 2.9 (stat) +/- 4.9 (syst) pb,
in good agreement with the Standard Model expectation. From this result the CKM
matrix element |V_{tb}| = 1.03{+0.16}{-0.19} is derived assuming that the Wt
production through |V_{ts}| and |V_{td}| is small.Comment: 9 pages plus author list (23 pages total), 3 figures, 2 tables,
  matches published version to appear in PL
Signature Sequence of Intersection Curve of Two Quadrics for Exact Morphological Classification

International audienceWe present an efficient method for classifying the morphology of the intersection curve of two quadrics (QSIC) in PR3, 3D real projective space; here, the term morphology is used in a broad sense to mean the shape, topological, and algebraic properties of a QSIC, including singularity, reducibility, the number of connected components, and the degree of each irreducible component, etc. There are in total 35 different QSIC morphologies with non-degenerate quadric pencils. For each of these 35 QSIC morphologies, through a detailed study of the eigenvalue curve and the index function jump we establish a characterizing algebraic condition expressed in terms of the Segre characteristics and the signature sequence of a quadric pencil. We show how to compute a signature sequence with rational arithmetic so as to determine the morphology of the intersection curve of any two given quadrics. Two immediate applications of our results are the robust topological classification of QSIC in computing B-rep surface representation in solid modeling and the derivation of algebraic conditions for collision detection of quadric primitives
Search for pair production of third-generation scalar leptoquarks and top squarks in proton-proton collisions at sqrt(s) = 8 TeV

A search for pair production of third-generation scalar leptoquarks and supersymmetric top quark partners, top squarks, in final states involving tau leptons and bottom quarks is presented. The search uses events from a data sample of proton–proton collisions corresponding to an integrated luminosity of 19.7 fb−1, collected with the CMS detector at the LHC with View the MathML sources=8 TeV. The number of observed events is found to be in agreement with the expected standard model background. Third-generation scalar leptoquarks with masses below 740 GeV are excluded at 95% confidence level, assuming a 100% branching fraction for the leptoquark decay to a tau lepton and a bottom quark. In addition, this mass limit applies directly to top squarks decaying via an R-parity violating coupling View the MathML sourceλ333′. The search also considers a similar signature from top squarks undergoing a chargino-mediated decay involving the R-parity violating coupling View the MathML sourceλ3jk′. Each top squark decays to a tau lepton, a bottom quark, and two light quarks. Top squarks in this model with masses below 580 GeV are excluded at 95% confidence level. The constraint on the leptoquark mass is the most stringent to date, and this is the first search for top squarks decaying via View the MathML sourceλ3jk′
Planck 2013 results. XXXII. the updated Planck catalogue of Sunyaev-Zeldovich sources

We update the all-sky Planck catalogue of 1227 clusters and cluster candidates (PSZ1) published in March 2013, derived from detections of the Sunyaev-Zeldovich (SZ) effect using the first 15.5 months of Planck satellite observations. As an addendum, we deliver an updated version of the PSZ1 catalogue, reporting the further confirmation of 86 Planck-discovered clusters. In total, the PSZ1 now contains 947 confirmed clusters, of which 214 were confirmed as newly discovered clusters through follow-up observations undertaken by the Planck Collaboration. The updated PSZ1 contains redshifts for 913 systems, of which 736 (~ 80.6%) are spectroscopic, and associated mass estimates derived from the Yz mass proxy. We also provide a new SZ quality flag for the remaining 280 candidates. This flag was derived from a novel artificial neural-network classification of the SZ signal. Based on this assessment, the purity of the updated PSZ1 catalogue is estimated to be 94%. In this release, we provide the full updated catalogue and an additional readme file with further information on the Planck SZ detections
F_q[M_n], F_q[GL_n] and F_q[SL_n] as quantized hyperalgebras

Within the quantum function algebra F_q[GL_n], we study the subset F'_q[GL_n]— introduced in [F. Gavarini, Quantization of Poisson groups, Pacific J. Math. 186 (1998) 217–266] — of all elements of F_q[GL_n] which are Z[q,q^{−1}]-valued when paired with U'_q(gln), the unrestricted Z[q,q^{−1}]-integral form of U_q(gl_n) introduced by De Concini, Kac and Procesi. In particular we obtain a presentation of it by generators and relations, and a PBW-like theorem. Moreover, we give a direct proof that F'_q[GL_n] is a Hopf subalgebra of F_q[GL_n], and that F'_1[GL_n] - i.e., the specialization of F'_q[GL_n] at q=1 - is isomorphic to U(gl_n^*). We describe explicitly its specializations at roots of 1, say ε, and the associated quantum Frobenius (epi)morphism from F'_ε[GL_n] to F'_1[GL_n], also introduced in [F. Gavarini, Quantization of Poisson groups, Pacific J. Math. 186 (1998) 217–266]. The same analysis is done for F_q[SL_n] and (as key step) for F_q[M_n]