pinecone/core-2020-05-10-deduplication huggingface dataset:
Search for a light charged Higgs boson in top quark decays in pp collisions at √s = 7 TeV

Results are presented on a search for a light charged Higgs boson that can be produced in the decay of the top quark t → H +b and which, in turn, decays into τ +ν t. The analysed data correspond to an integrated luminosity of about 2 fb -1 recorded in protonproton collisions at √s = 7 TeV by the CMS experiment at the LHC. The search is sensitive to the decays of the top quark pairs tt̄ → H ±W ∓bb̄ and tt̄ → H ±H ∓bb̄. Various final states have been studied separately, all requiring presence of a τ lepton from H + decays, missing transverse energy, and multiple jets. Upper limits on the branching fraction B(t → H +b) in the range of 2-4% are established for charged Higgs boson masses between 80 and 160 GeV, under the assumption that B(H + → τ +ν τ) = 1.The Scientific and Technical Research Council of Turkey, and Turkish Atomic Energy Authorit
Comparison of time domain numerical solvers for the propagation of a Gaussian pulse inside a rectangular waveguide

We analyse techniques for increasing the accuracy and efficiency of a finite-volume time-domain (FV-TD) cell-centred computational methodology. Various state-of-the-art spatial and temporal discretisation methods employed to solve Maxwell equations on multi-dimensional structured grid networks are investigated and the dispersive and dissipative errors inherent in those techniques examined. Both staggered and unstaggered grid approaches are considered. Staggered and unstaggered Leapfrog and Runge-Kutta time integration methods are analysed by the use of Gaussian microwave pulse simulations. The implementation of typical electromagnetic boundary conditions is also deliberated. Finally, a comparison of the classical finite-difference time-domain (FD-TD) method and FV-TD numerical results for a standard case study in rectangular waveguides allows the accuracy of the developed methods to be assessed. © Austral. Mathematical Soc. 2003
Stochastic modelling and simulations for solute transport in porous media

A stochastic model for solute transport in aquifers is studied based on the concepts of stochastic velocity and stochastic diffusivity. By applying finite difference techniques to the spatial variables of the stochastic governing equation, a system of stiff stochastic ordinary differential equations is obtained. Both the semi-implicit Euler method and the balanced implicit method are used for solving this stochastic system. Based on the Karhunen-Loeve expansion, stochastic processes in time and space are calculated by means of a spatial correlation matrix. Four types of spatial correlation matrices are presented based on the hydraulic properties of physical parameters. Simulations with two types of correlation matrices are presented
Robustness of mathematical models for biological systems

The robustness of mathematical models for biological systems is studied by sensitivity analysis and stochastic simulations. Using a neural network model with three genes as the test problem, we study robustness properties of synthesis and degradation processes. For single parameter robustness, sensitivity analysis techniques are applied for studying parameter variations and stochastic simulations are used for investigating the impact of external noise. Results of sensitivity analysis are consistent with those obtained by stochastic simulations. Stochastic models with external noise can be used for studying the robustness not only to external noise but also to parameter variations. For external noise we also use stochastic models to study the robustness of the function of each gene and that of the system
Optimising offsets and bandwidths in vehicle traffic networks

Bandwidths and offsets are important components in vehicle traffic control strategies. This article proposes new methods for quantifying and selecting them. Bandwidth is the amount of green time available for vehicles to travel through adjacent intersections without the requirement to stop at the second traffic light. The offset is the difference between the starting-time of ``green'' periods at two adjacent intersections, along a given route. The core ideas in this article were developed during the 2013 Maths and Industry Study Group in Brisbane, Australia. Analytical expressions for computing bandwidth, as a function of offset, are developed. An optimisation model, for selecting offsets across an arterial, is proposed. Arterial roads were focussed upon, as bandwidth and offset have a greater impact on these types of road as opposed to a full traffic network. A generic optimisation-simulation approach is also proposed to refine an initial starting solution, according to a specified metric. A metric that reflects the number of stops, and the distance between stops, is proposed to explicitly reduce the dissatisfaction of road users, and to implicitly reduce fuel consumption and emissions. Conceptually the optimisation-simulation approach is superior as it handles real-life complexities and is a global optimisation approach. The models and equations in this article can be used in road planning and traffic control
Introduction to discrete functional analysis techniques for the
  numerical study of diffusion equations with irregular data

We give an introduction to discrete functional analysis techniques for
stationary and transient diffusion equations. We show how these techniques are
used to establish the convergence of various numerical schemes without assuming
non-physical regularity on the data. For simplicity of exposure, we mostly
consider linear elliptic equations, and we briefly explain how these techniques
can be adapted and extended to non-linear time-dependent meaningful models
(Navier--Stokes equations, flows in porous media, etc.). These convergence
techniques rely on discrete Sobolev norms and the translation to the discrete
setting of functional analysis results
Cambodia Report : Feeding China's Expanding Demand for Wood Pulp
 : 
A Diagnostic Assessment of Plantation Development, Fiber Supply, and Impacts on Natural Forests in China and in the South East Asia Region

32 p ISBN 979-24-4675-3After decades of war, Cambodia is one of the world's poorest nations, its economy and its political life are still suffering from the civil war that racked the country during the latter part of the 20th century. Rice and rubber were traditionally the principal exports of Cambodia, but exports fell sharply after the onset of the civil war, which put most of the rubber plantations out of operation. By the 1990s, however, rubber plantings had been undertaken as part of a national recovery program, and rubber and rice were again being exported. The fishing industry has also somehow been revived, but some food shortages continue. From this period, the largest source of export income has been timber, until the Cambodian government set up a “log export” ban in 1995. With a rather limited national environment supporting the development of an internationally competitive wood processing industry, this industry sector has not benefited from this ban. Wood material exports have continued under a limited processed form, i.e. squared logs and thick boards. Up to now, no development of any wood pulp or chipping industry has been impossible in Cambodia. Additionally, in 2002, any logging activity has been suspended for any forest companies, until the approval of their new forest concessions. Some forest companies which had old logs (harvested before 2001) were still authorized to process them. Further, in 2003, a large portion of the territory (about 24%) was declared as protected area. The industrial growth of the country is now mainly sustained by the garment and tourism sectors. But until now, inadequate transportation hampers the development of national industries, except in some “development pockets”. This poor transportation is a major impediment for the development of pulp wood plantations or pulp and chipping industries in Cambodia
Connection between heat diffusion and heat conduction in one-dimensional
  systems

Heat and energy are conceptually different, but often are assumed to be the
same without justification. An effective method for investigating diffusion
properties in equilibrium systems is discussed. With this method, we
demonstrate that for one-dimensional systems, using the indices of particles as
the space variable , which has been accepted as a convention, may lead to
misleading conclusions. We then show that though in one-dimensional systems
there is no general connection between energy diffusion and heat conduction,
however, a general connection between heat diffusion and heat conduction may
exist. Relaxation behavior of local energy current fluctuations and that of
local heat current fluctuations are also studied. We find that they are
significantly different, though the global energy current equals the globe heat
current.Comment: 6 pages,3 figure
Possessive Constructions in Egyptian and Coptic. Distribution, definiteness, and the construct state phenomenon

In this paper, the distribution of Coptic possessive constructions is defined in terms of syntactic constraints: the construction involving the linking element N- requires the obligatory (and simple) definiteness of the possessed noun as well as the strict adjacency of regens and rectum. In relation to a comparison made between this Coptic possessive pattern and the so-called construct state phenomenon, a historical overview of the Egyptian language is given to explore the possible reconstruction of a true construct state formation in the earlier language stages
StratusLab Cloud Distribution

International audienceCloud technologies provide many benefits for scientific and engineering applications, such as customised execution environments, near-instantaneous provisioning, elasticity, and the ability to run user-level services. However, a rapid, wholesale shift to using public, commercial cloud services is unlikely because of capital investments in existing resources and data management issues. To take full advantage of cloud technologies in the short term, institutes and companies must be able to deploy their own cloud infrastructures. The StratusLab project provides a complete, open-source cloud distribution that permits them to do this. The StratusLab services include the computing, storage, and networking services required for an Infrastructure as a Service (IaaS) cloud. It also includes high-level services like the Marketplace that facilitates the sharing of machine images and Claudia that allows the deployment and management of complete software systems
A Randomized, Double-blind, Placebo-Controlled Study of Latrepirdine in Patients With Mild to Moderate Huntington Disease.

BACKGROUND Latrepirdine is an orally administered experimental small molecule that was initially developed as an antihistamine and subsequently was shown to stabilize mitochondrial membranes and function, which might be impaired in Huntington disease. OBJECTIVE To determine the effect of latrepirdine on cognition and global function in patients with mild to moderate Huntington disease. DESIGN Randomized, double-blind, placebo-controlled study. SETTING Sixty-four research centers in Australia, Europe, and North America. PATIENTS Four hundred three patients with mild to moderate Huntington disease and baseline cognitive impairment (Mini-Mental State Examination score, 10-26). INTERVENTION Latrepirdine (20 mg) vs matching placebo administered orally 3 times daily for 26 weeks. MAIN OUTCOME MEASURES The co-primary outcome measures were cognition as measured by the change in Mini-Mental State Examination score from baseline to week 26 and global function at week 26 as measured by the Clinician Interview-Based Impression of Change, plus carer interview, which ranges from 1 (marked improvement) to 7 (marked worsening). Secondary efficacy outcome measures included behavior, daily function, motor function, and safety. RESULTS The mean change in Mini-Mental State Examination score among participants randomized to latrepirdine (1.5-point improvement) did not differ significantly from that among participants randomized to placebo (1.3-point improvement) (P = .39). Similarly, the distribution of the Clinician Interview-Based Impression of Change, plus carer interview did not differ significantly among those randomized to latrepirdine compared with placebo (P = .84). No significant treatment effects were detected on the secondary efficacy outcome measures. The incidence of adverse events was similar between those randomized to latrepirdine (68.5%) and placebo (68.0%). CONCLUSION In patients with mild to moderate Huntington disease and cognitive impairment, treatment with latrepirdine for 6 months was safe and well tolerated but did not improve cognition or global function relative to placebo. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00920946
Predicting Treatment Response in Social Anxiety Disorder From Functional Magnetic Resonance Imaging

Context: Current behavioral measures poorly predict treatment outcome in social anxiety disorder (SAD). To our knowledge, this is the first study to examine neuroimaging-based treatment prediction in SAD.
Objective: To measure brain activation in patients with SAD as a biomarker to predict subsequent response to cognitive behavioral therapy (CBT).
Design: Functional magnetic resonance imaging (fMRI) data were collected prior to CBT intervention. Changes in clinical status were regressed on brain responses and tested for selectivity for social stimuli.
Setting: Patients were treated with protocol-based CBT at anxiety disorder programs at Boston University or Massachusetts General Hospital and underwent neuroimaging data collection at Massachusetts Institute of Technology.
Patients: Thirty-nine medication-free patients meeting DSM-IV criteria for the generalized subtype of SAD.
Interventions: Brain responses to angry vs neutral faces or emotional vs neutral scenes were examined with fMRI prior to initiation of CBT.
Main Outcome Measures: Whole-brain regression analyses with differential fMRI responses for angry vs neutral faces and changes in Liebowitz Social Anxiety Scale score as the treatment outcome measure.
Results: Pretreatment responses significantly predicted subsequent treatment outcome of patients selectively for social stimuli and particularly in regions of higher-order visual cortex. Combining the brain measures with information on clinical severity accounted for more than 40% of the variance in treatment response and substantially exceeded predictions based on clinical measures at baseline. Prediction success was unaffected by testing for potential confounding factors such as depression severity at baseline.
Conclusions: The results suggest that brain imaging can provide biomarkers that substantially improve predictions for the success of cognitive behavioral interventions and more generally suggest that such biomarkers may offer evidence-based, personalized medicine approaches for optimally selecting among treatment options for a patient
Retinoids strongly and selectively correlate with keratin 13 and not keratin 19 expression in cutaneous warts of renal transplant recipients.

Contains fulltext :
                  144559.pdf (publisher's version ) (Open Access)OBJECTIVE: To compare the expression of keratin (K) 13 and K19 in cutaneous warts of renal transplant recipients (RTRs) and immunocompetent individuals (ICIs). DESIGN: Retrospective, nonrandomized immunohistochemical study. PATIENTS AND METHODS: Specimens from cutaneous warts of RTRs and ICIs were retrieved from the archives of the Department of Pathology, University Medical Center St Radboud, Nijmegen, the Netherlands. Twenty-one warts from RTRs and 21 from ICIs were examined. Nine RTRs (10 specimens) received either systemic acitretin or topical all-trans retinoic acid, and their effect on both keratins was assessed. MAIN OUTCOME MEASURES: Frequency and expression patterns of K13 and K19 in warts of RTRs vs ICIs and the effect of retinoids. RESULTS: A significantly higher percentage of warts of RTRs expressed K13 compared with warts of ICIs (86% vs 14%, 18 vs 3 cases, respectively; P<.001). In warts of RTRs, retinoid treatment correlated significantly with a particularly strong, segmental K13 expression pattern, which we termed zebroid. Without use of retinoids, K13 was mostly restricted to suprabasal single cells. Keratin 19 was absent in all warts of both patient groups. CONCLUSIONS: Retinoids strongly correlate with K13 in a characteristic zebroid pattern in warts of RTRs, making K13 a sensitive marker for retinoid bioactivity in skin (lesions) of RTRs. In non-retinoid-treated RTRs, K13 is also frequently found in warts but without the dramatic zebroid pattern noted in retinoid-treated warts
Quality of abstracts in 3 clinical dermatology journals

Background Structured abstracts have been widely adopted in medical journals, with little demonstration of their superiority over unstructured abstracts.Objectives: To compare abstract quality among 3 clinical dermatology journals and to compare the quality of structured and unstructured abstracts within those journals. Design and Data Sources: Abstracts of a random sample of clinical studies (case reports, case series, and reviews excluded) published in 2000 in the Archives of Dermatology, The British Journal of Dermatology, and the Journal of the American Academy of Dermatology were evaluated. Each abstract was rated by 2 independent investigators, using a 30-item quality scale divided into 8 categories (objective, design, setting, subjects, intervention, measurement of variables, results, and conclusions). Items applicable to the study and present in the main text of the article were rated as being present or absent from the abstract. A global quality score (range, 0-1) for each abstract was established by calculating the proportion of criteria among the eligible criteria that was rated as being present. A score was also calculated for each category. Interrater agreement was assessed with a {kappa} statistic. Mean ± SD scores were compared among journals and between formats (structured vs unstructured) using analysis of variance. Main Outcome Measures: Mean quality scores of abstracts by journal and by format. Results: Interrater agreement was good ({kappa} = 0.71). Mean ± SD quality scores of abstracts were significantly different among journals (Archives of Dermatology, 0.78 ± 0.07; The British Journal of Dermatology, 0.67 ± 0.17; and Journal of the American Academy of Dermatology, 0.64 ± 0.15; P = .045) and between formats (structured, 0.71 ± 0.11; and unstructured, 0.56 ± 0.18; P = .002). The setting category had the lowest scores. Conclusions: The quality of abstracts differed across the 3 tested journals. Unstructured abstracts were demonstrated to be of lower quality compared with structured abstracts and may account for the differences in quality scores among the journals. The structured format should be more widely adopted in dermatology journals
Multiple primary melanomas in a CDKN2A mutation carrier exposed to ionizing radiation

Background: Recent research has shown a possible causal relationship between ionizing radiation exposure and melanoma. Individuals with mutations in CDKN2A (cyclin-dependent kinase inhibitor 2A), the major melanoma predisposition gene, have an increased susceptibility to melanoma-promoting exposures, such as UV light. We describe a patient from a familial melanoma pedigree with 7 primary melanomas on the right side of her body, the first occurring 5 years after exposure to atmospheric nuclear bomb testing in the 1950s. Observations: Physical examination revealed phototype I skin, red hair, and 26 nevi (14 on the right and 12 on the left side of her body). One nevus was larger than 5 mm, and 2 were clinically atypical. Sequence analysis demonstrated a known deleterious mutation in CDKN2A (G-34T) and homozygosity for a red hair color variant in MC1R (melanocortin 1 receptor) (R151C). Fluorescence in situ hybridization analysis of blood, fibroblasts, and melanocytes from both upper extremities ruled out mosaicism. Conclusions: Individuals such as this patient, who has CDKN2A and MC1R mutations, are likely to be more susceptible to environmental insults. A careful review of environmental exposures in these vulnerable cases may reveal cancer-promoting agents, such as ionizing radiation, that go unnoticed in less susceptible populations
Factors associated with the number of lesions excised for each skin cancer: A study of primary care physicians in Queensland, Australia

Objective: To assess physician, patient, and skin lesion characteristics that affect the number of benign skin lesions excised by primary care physicians for each skin cancer. Design: Prospective study collecting clinical, patient, and histopathologic details of excisions or biopsies of skin lesions by random samples of primary care physicians. Setting: Southeast Queensland involving traditional family medicine physicians (n=104; response rate,53.9%) and family medicine physicians working in 27 primary care skin cancer clinics (n=50; response rate,75.0%). Participants: Of 28 755 skin examinations recorded during the study, 11 403 skin lesions were excised or biopsied; 97.5% of the excised lesions had clinical and histologic diagnoses recorded. Main Outcome Measures: Number of lesions needed to excise or biopsy (NNE) for 1 melanoma (pigmented lesions only) and NNE for 1 nonmelanoma skin cancer (nonpigmented lesions only). Results: The NNE for nonpigmented lesions (n=8139) was 1.5 (95% confidence interval, 1.4-1.6) and for pigmented lesions (n=2977) was 19.6 (16.2-22.9). TheNNE estimates were up to 8 times lower if the physician thought the lesion was likely to be malignant and up to 2.5 times higher if there was strong patient pressure to excise. The NNE estimates varied by other physician-, patient-, and lesion-related variables. Conclusions: Clinical impressions of excised skin lesions were strongly associated with NNE estimates. By focusing on pigmented skin lesions and by addressing the physician- and patient-specific factors identified,the effectiveness of future training for primary care physicians in the clinical management of skin cancer could be improved
Ichthyosis, exocrine pancreatic insufficiency, impaired neutrophil chemotaxis, growth retardation, and metaphyseal dysplasia (Shwachman syndrome).

The Shwachman syndrome comprises exocrine pancreatic insufficiency, growth retardation, and bone marrow hypoplasia resulting in neutropenia. Clinical, morphological, and ultrastructural studies, as well as hair analysis, were performed in a patient with Shwachman's syndrome and severe ichthyosis. Clinical findings were lamellar ichthyosiform desquamation on the extremities. The hair was scanty and short on the scalp, in the eyelashes, and in the eyebrows. The nails were hyperkeratotic. Morphologic findings were slight, regular acanthosis and severe diffuse hyperkeratosis with variable parakeratosis. The granular layer was thickened. The papillary dermis showed very slight perivascular lymphocyte infiltration. The most prominent ultrastructural finding was the presence of solitary or multiple droplets of varying size in the cytoplasm of the keratinocytes. Hair analysis revealed no abnormalities; the cystine concentration in hair specimens was normal