pinecone/core-2020-05-10-deduplication huggingface dataset:
Impact of source/drain contacts formation of self-aligned amorphous-IGZO TFTs on their negative-bias-illumination-stress stabilities

In this study, we have compared the performance of self-aligned a-IGZO thin-film transistors (TFTs) whereby the source/drain (S/D) region's conductivity enhanced in three different ways, that is, using SiNx interlayer plasma (hydrogen diffusion), using calcium (Ca as reducing metal) and using argon plasma (changing the atomic ratio). All these TFTs show comparable characteristics such as field-effect mobility (μFE) of over 10.0 cm2/(V.s), sub-threshold slope (SS-1) of 0.5 V/decade, and current ratio (ION/IOFF) over 108. However, under negative-bias-illumination-stress (NBIS), all these TFTs showed strong degradation. We attributed this NBIS stability issue to the exposed S/D regions and changes in the conductivity of S/D contact regions. The hydrogen plasma-treated TFTs showed the worst NBIS characteristics. This is linked to increased hydrogen diffusion from the S/D contact regions to the channelstatus: publishe
Characteristics improvement of top-gate self-aligned amorphous indium gallium zinc oxide thin-film transistors using a dual-gate control

In this work, we have reported dual-gate amorphous indium gallium zinc oxide thin-film transistors (a-IGZO TFTs), where a top-gate self-aligned TFTs has a secondary bottom gate and the TFT integration comprises only five mask steps. The electrical characteristics of a-IGZO TFTs under different gate control are compared. With the enhanced control of the channel with two gates connected together, parameters such as on current (ION), sub-threshold slope (SS−1), output resistance, and bias-stress instabilities are improved in comparison with single-gate control self-aligned a-IGZO TFTs. We have also investigated the applicability of the dual-gate a-IGZO TFTs in logic circuitry such as 19-stage ring oscillators.status: publishe
Surgical Treatment of Extravasation Injuries

Surgical treatment of extravasation injuries.\ud
\ud
Napoli P, Corradino B, Badalamenti G, Tripoli M, Vieni S, Furfaro MF, Cordova A, Moschella F.\ud
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Source\ud
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Chirurgia Plastica e Ricostruttiva, Dipartimento di Discipline Chirurgiche ed Oncologiche, Università degli Studi di Palermo, Italy. pietronapoli@libero.it\ud
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\ud
Abstract\ud
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The authors present their experience of treating anti-cancer drug extravasation by means of a composite surgical technique that consists of infiltration with physiological solution and hyaluronidase and subsequent manual aspiration of solutes alternated with profuse irrigation of the infiltrated area. In the immediate post-op we carry out a medical therapy that consists of calciparine and topic antibiotic and/or steroid creams. Since the year 2000 this technique has been used on 25 patients. We have had neither complications nor scars
A comparison of surgical outcomes between endoscopic and robotically assisted thyroidectomy: the authors’ initial experience

Background: The gasless, transaxillary endoscopic thyroidectomy (GTET) offers a distinct advantage over the conventional open operation by leaving no visible neck scar, and in an attempt to improve its ergonomics and surgical outcomes, the robotically assisted thyroidectomy (RAT) was introduced. The RAT uses the same endoscopic route as the GTET but with the assistance of the da Vinci S robotic system. Excellent results for RAT have been reported, but it remains unclear whether RAT offers any potential benefits over GTET. Methods: From June to December 2009, 46 patients underwent endoscopic thyroidectomy. Of these patients, 39 had surgery without the robot (GTET) and 7 had surgery with the robot (RAT). Demographics, surgical indications, operative findings, and postoperative outcomes were compared between the two groups. All the patients were followed up for at least 6 months after surgery. Results: Patient demographics, surgical indications, and extent of resection were similar between the two groups. The median total procedure time was significantly longer for RAT (149 min) than for GTET (100 min; p = 0.018), but the contralateral recurrent laryngeal nerve was more likely to identified in RAT (100%) than in GTET (42.9%; p = 0.070). On the average, GTET needed one more surgical assistant than RAT (1 vs. 0; ppublished_or_final_versionSpringer Open Choice, 21 Feb 201
Portal vein embolization (prior to major hepatectomy) effects on regeneration, resectability, and outcome

Portal vein embolization (PVE) is used to increase the volume and function of the liver that will remain after extensive liver resection. Operative outcomes are improved in properly selected patients who undergo PVE and experience adequate future liver remnant (FLR) hypertrophy. Absolute volume and volume change of the FLR after PVE (interpreted in context of liver disease) predict adequate liver function postresection. Oncologic outcomes following resection in patients with appropriately applied PVE are excellent. J. Surg. Oncol. 2010;102:960–967. © 2010 Wiley-Liss, Inc.PublishedN/
Systemic therapy for advanced gastrointestinal stromal tumors: Beyond imatinib

Progression on first‐line therapy with imatinib in gastrointestinal stromal tumors (GIST) is caused by either initial resistance or more often a secondary mutation in tyrosine kinases KIT or PDGFR. Therapies in development for imatinib‐resistant GIST include agents that target KIT/PDGFR with greater potency or possess broader kinase inhibition profiles including VEGFR. To circumvent secondary mutations in KIT/PDGFR, inhibition of the downstream signaling in PI3K/Akt/mTOR pathway and enhanced degradation of KIT/PDGFR are also under investigation. J. Surg. Oncol. 2011; 104:901–906. © 2011 Wiley Periodicals, Inc
Morphology of gastrointestinal stromal tumors: Historical perspectives

About 2/3 of gastrointestinal stromal tumors occur in the stomach and about 1/5 in the small intestine with few in the rectum, colon, and esophagus. Their cells are related to the interstitial cells of Cajal. They differ by site in terms of cell type and growth pattern. Benign and malignant tumors are separated based on their light microscopic appearances, size as measured by innumerable pathologists and assistants and mitotic counts. J. Surg. Oncol. 2011; 104:874–881. © 2011 Wiley Periodicals, Inc
Surgical options for localized and advanced gastrointestinal stromal tumors

The development of imitinab has led to a revolution in the management of gastrointestinal stromal tumors (GIST), but surgical resection remains the cornerstone of treatment for patients with localized disease. The principles to surgical treatment of GIST include careful handling of tissues to prevent tumor rupture and resection to negative margins without the need for wide excision. Minimally invasive techniques have proven equally efficacious provided appropriate oncologic resections are performed. J. Surg. Oncol. 2011; 104:882–887. © 2011 Wiley Periodicals, Inc
Advanced or metastatic gastrointestinal stromal tumors: Systemic treatment options

Gastrointestinal stromal tumor (GIST), the most common sarcoma arising in the gastrointestinal tract, typically expresses the tyrosine‐kinase receptor, C‐KIT, and contains activating mutation in the  c‐kit  or platelet‐derived growth factor receptor ( pdgfr ) gene. Recently, development of small molecules that inhibit the kinase activity of mutant C‐KIT and PDGFR proteins has radically changed treatment and prognosis of patients diagnosed with advanced GIST as this molecularly “targeted” therapy has demonstrated remarkable high‐level of activity in this disease. J. Surg. Oncol. 2011; 104:888–895. © 2011 Wiley Periodicals, Inc
Is a level III dissection necessary for a positive sentinel lymph node in melanoma?

Background  For melanoma patients with a positive axillary SLN, the extent of ALND remains controversial, with debate over whether a level III dissection is needed.    Methods  We queried our IRB approved prospective database for patients with a positive axillary SLN who had a level I/II dissection only, and compared recurrence and complication rates to the existing literature.    Results  Between 1998 and 2008, 270 patients had 285 level I/II ALNDs for a positive SLN. Median number of SLN removed was 2, while the median number of involved SLN was 1 (range 1–4). An average of 18.7 nodes/ALND were removed, with 13% having positive non‐SLN. Post‐operative complications occurred in 31 patients (11%), primarily cellulitis (8%). After a mean follow‐up of 44 months, 14 patients had a regional recurrence in the axillary basin (5%).    Conclusions  The complication rate and regional recurrence rate for patients undergoing a level I/II ALND for a positive SLN are either lower than or on par with reported series of ALND for level I, II, and III dissections, suggesting that in this setting, the level III dissection may be of minimal benefit. J. Surg. Oncol. 2012; 105:225–228. © 2011 Wiley Periodicals, Inc
B lymphocytes as effector cells in the immunotherapy of cancer

Over the years, the role of B cells in the host immune response to malignancy has been overshadowed by our focus on T cells. Nevertheless, B cells play important roles as antigen‐presenting cells and in the production of antibodies. Furthermore, B cells can function as effector cells that mediate tumor destruction on their own. This review will highlight the various functions of B cells that are involved in the host response to tumor. J. Surg. Oncol. 2012;105:431–435. © 2011 Wiley Periodicals, Inc
Analytic morphometric assessment of patients undergoing colectomy for colon cancer

Background  Analytic morphometrics provides objective data that may better stratify risk. We investigated morphometrics and outcome among colon cancer patients.    Methods  An IRB‐approved review identified 302 patients undergoing colectomy who had CT scans. These were processed to measure psoas area (PA), density (PD), subcutaneous fat (SFD), visceral fat (VF), and total body fat (TBF). Correlation with complications, recurrence, and survival were obtained by  t ‐tests and linear regression models after adjusting for age and Charlson index.    Results  The best predictor of surgical complications was PD. PMH, Charlson, BMI, and age were not significant when PD was considered. SF area was the single best predictor of a wound infection. While all measures of obesity correlated with outcome, TBF was most predictive. Final multivariate Cox models for survival included age, Charlson score, nodal positivity, and TBF.    Conclusions  Analytic morphometric analysis provided objective data that stratified complications and outcome better than age, BMI, or co‐morbidities.  J. Surg. Oncol. 2013; 108:169–175 . © 2013 Wiley Periodicals, Inc
The true prognosis of resected distal cholangiocarcinoma

International audienceBACKGROUND: Prognosis of distal cholangiocarcinoma (DCC) after pancreaticoduodenectomy (PD) remains poorly assessed. The aims of this study were to describe the oncological results of PD in DCC and to compare its prognosis to pancreatic ductal adenocarcinoma (PDAC). METHODS: All PD for periampullary carcinoma performed between January 2000 and March 2013 were extracted from a prospective database. Risk factors likely to influence overall (OS) and disease-free (DFS) survivals of DCC were assessed by multivariable analyses. The DCC and PDAC prognoses were compared after matching using propensity score (nearest neighbor matching). RESULTS: Of the 290 patients analyzed, 56 had DCC, with a mean age of 65 ± 15 years. The median OS was 36.9 months. Recurrence occurred in 35 patients (67%), mostly in the liver (37%). The median DFS was 14.6 months. Combined organ resection was an independent risk factor for worse OS and DFS (P = 0.01 and P = 0.001, respectively). Matching analysis found no significant difference between DCC and PDAC in terms of OS (P = 0.284) or DFS (P = 0.438). CONCLUSION: This first propensity analysis demonstrated that DCC and PDAC have the same prognosis, linked to the high rate of early recurrence, particularly associated with the need for combined organ resection. J. Surg. Oncol. © 2016 Wiley Periodicals, In
Functional outcome after surgery in patients with bone sarcoma around the knee; results from a long-term prospective study

Background and Objectives: In a previous conducted study functional outcome of young patients with bone sarcoma located around the knee was longitudinally evaluated during the first 2 years postoperatively. Functional outcome improved significantly over the first 2 years. The purpose of this descriptive study was to evaluate the functional outcome of these patients at long-term follow-up of 7 years. Methods: Functional outcome was assessed with the TESS, MSTS, Baecke questionnaire, and three functional performance tests: time up and down stairs (TUDS), various walking activities (VWA), and the 6-min walking test (6MWT). Linear Mixed Model has been employed for the repeated measurements. Results: Twenty patients of the original study (n=44) participated in the current study. Fifteen limb-salvage and five ablative surgery patients, median follow-up 7.4 years (6.8-8.0) (CI 95%), mean age 22.3 years (18.2-31.6). Between 2 and 7 years after surgery, 8 limb-salvage patients (53%) encountered surgery related complications. Questionnaires and functional performance tests showed no significant difference in functional outcome between 2 years and 7 years after surgery (P<0.05). Conclusions: Between 2 years and follow-up at average 7 years after surgery no further improvements were noticed at young patients with a bone sarcoma located around the knee
Analysis of natural antioxidants by capillary electromigration methods

In this work, an exhaustive survey of capillary electromigration methods used to analyze\ud
natural antioxidants is presented together with some discussion of the use of\ud
these substances use as functional foods. This review provides an updated and\ud
exhaustive overview of the separation and identification by capillary electrophoresis\ud
of natural compounds with antioxidant activity found in natural matrices and/or foods.\ud
The compounds concerned are catechins, isoflavones, anthocyanins, phenolic acids,\ud
vitamins, as well as other less common natural substances that have shown antioxidant\ud
activity.MH would like to thank MCYT for a FPI grant. Authors\ud
thank MCYT (project AGL2002-04621-C02-02) for financial\ud
support.Peer reviewe
Detection and quantitation of additions of soybean proteins in cured-meat products by perfusion reversed-phase high-performance liquid chromatography

Perfusion liquid chromatography has been applied in this work to the determination of soybean proteins in commercially available cured meat products, enabling the detection of additions of soybean proteins in cured meat products to which the addition of these vegetable proteins is forbidden and the quantitation of soybean proteins in cured meat products to which the addition of these proteins is allowed up to a certain limit. The analytical methodology is based on a sample treatment (fat extraction and soybean protein solubilization) prior to chromatographic analysis. Fat extraction with acetone and soybean protein solubilization with a buffer solution at basic pH (pH 10 or 9) were necessary to obtain selective and sensitive conditions. Use of water-acetonitrile-trifluoroacetic acid or water-tetrahydrofuran-trifluoroacetic acid linear binary gradients at a flow rate of 3 mL/min, a temperature of 50 degrees C, and UV detection at 280 nm enabled chromatographic analysis of soybean proteins in cured meat products in less than 3 min.The authors thank the Comunidad Autónoma de Madrid\ud
(Spain) for project 07G/0025/2003. Dr. C. García-Ruiz\ud
also thanks the Ministerio de Ciencia y Tecnolog a for her\ud
contract from the Ramón y Cajal program (RYC-2003-001). F. Castro-Rubio thanks the Ministerio de Educación\ud
y Ciencia (Spain) for her predoctoral grant
Analysis of pesticides in soy milk combining solid-phase extraction and capillary electrophoresis-mass spectrometry

In this work, the determination of a group of triazolopyrimidine sulfoanilide herbicides (cloransulam-methyl, metosulam, flumetsulam, florasulam and diclosulam) in soy milk by capillary electrophoresis-mass spectrometry (CE-MS) is presented. The main electrospray interface (ESI) parameters (nebulizer pressure, dry gas flow rate, dry gas temperature and composition of the sheath liquid) are optimized using a central composite design. To increase the sensitivity of the CE-MS method, an off-line sample preconcentration procedure based on solid-phase extraction (SPE) is combined with an on-line stacking procedure (i.e. normal stacking mode, NSM). Samples could be injected up to 100 seconds, providing limits of detection (LODs) down to 74 μg/L, i.e., in the low ppb level, with relative standard deviation values (RSD, %) between 3.8% and 6.4% for peak areas for the same day, and between 6.5% and 8.1% for three different days. The usefulness of the optimized SPE-NSM-CE-MS procedure is demonstrated through the sensitive quantification of the selected pesticides in soy milk samples.J. Hernández-Borges thanks to the Ministerio de Educación y Ciencia de España for a\ud
FPU grant. This work has been supported by Consejería de Educación, Cultura y\ud
Deportes, Gobierno Autónomo de Canarias (Project 2002/074).Peer reviewe
Separation and online preconcentration by multistep stacking with large-volume injection of anabolic steroids by capillary electrokinetic chromatography using charged cyclodextrins and UV-absorption detection

The separation of three common anabolic steroids (methyltestosterone, methandrostenolone and testosterone) was performed for the first time by capillary EKC. Different charged CD derivatives and bile salts were tested as dispersed phases in order to achieve the separation. A mixture of 10 mmol/L succinylated-b-CD with 1 mmol/L bCD in a 50 mmol/L borate buffer (pH 9) enabled the separation of the three anabolic steroids in less than 9 min. Concentration LODs, obtained for these compounds with low absorption of UV light, were ~5610–5 mol/L. The use of online reverse migrating sample stacking with large-volume injection (the effective length of the capillary) enabled to improve the detection sensitivity. Sensitivity enhancement factors (SEFs) ranging from 95 (for testosterone) to 149 (for methyltestosterone) were achieved by single stacking preconcentration. Then, the possibilities of multistep stacking to improve the sensitivity for these analytes were investigated. SEFs obtained by double stacking preconcentration ranged from 138 to 185, enabling concentration LODs of 2.79610–7 mol/L (for methyltestosterone), 3.47610–7 mol/L (for testosterone) and 3.56610–7 mol/L (for methandrostenolone). Although online triple stacking preconcentration was achieved, its repeatability was very poor and SEFs for the studied analytes were not calculated
Analysis of the disaccharides derived from hyaluronic acid and chondroitin sulfate by capillary electrophoresis with sample stacking

CE conditions for monitoring the unsaturated disaccharides of hyaluronic acid (di-HA) and chondroitin sulfate (di-CS) using an alkaline tetraborate buffer, electrokinetic sample injection, and UV absorption detection at 232 nm are reported. Separations were performed in an uncoated fused-silica capillary having reversed polarity and reversed electroosmosis generated with the addition of CTAB to the buffer. The influence of various separation parameters, including the concentration of CTAB, buffer pH, concentration of tetraborate, and applied voltage, on the resolution of the two disaccharides was investigated. Baseline separation was obtained with 25 mM tetraborate at pH 10.0 and having 0.05 mM CTAB. Chloride and phosphate in the sample are beneficial for the stacking of the disaccharides, with di-HA forming a much sharper peak than di-CS. Using samples prepared in 25 mM Tris-HCl (pH 7.5) and electrokinetic injection at the cathode at -10 kV for 40 s, linear relationships between the corrected peak area and the concentration of the disaccharides have been found in the ranges of 1.0-400.0 and 0.1-1.0 {micro}g/mL (0.2-1.0 {micro}g/mL for di-CS), with correlation coefficients being >0.9933 in all cases. The RSDs of detection times and corrected peak areas were between 1.13-1.24 and 1.57-2.13%, respectively. Applied to human serum samples that were prepared by ethanol precipitation and depolymerization of the two polysaccharides with chondroitinase ABC reveals comigration of endogenous compounds with di-HA and a sample-dependent detection time. The di-HA content in the serum sample can be estimated via subtraction of the blank peak that is obtained without enzymatic hydrolysis
Separation and characterization of antioxidants from Spirulina platensis microalgacombining pressurized liquid extraction, TLC and HPLC-DAD

A new procedure has been developed to separate and characterize antioxidant compounds\ud
from Spirulina platensis microalga based on the combination of pressurized liquid extraction\ud
(PLE) and different chromatographic procedures, such as Thin-Layer Chromatography\ud
(TLC), at preparative scale, and High Performance Liquid Chromatography (HPLC) with a\ud
Diode Array Detector (DAD). Different solvents were tested for PLE extraction of\ud
antioxidants from Spirulina platensis microalga. An optimized pressurized liquid extraction\ud
process using ethanol (generally recognized as safe, GRAS) as extraction solvent has been\ud
obtained that provides natural extracts with high yields and good antioxidant properties. TLC\ud
analysis of this ethanolic extract obtained at 115°C for 15 min was carried out and the silica\ud
layer was stained with a DPPH• (diphenyl-pycril-hydrazyl) radical solution to determine the\ud
antioxidant activity of the different chromatographic bands. Next, these coloured bands were\ud
collected for their subsequent analysis by HPLC-DAD revealing that the compounds with the\ud
most important antioxidant activity present in Spirulina extracts were carotenoids, as well as\ud
phenolic compounds and degradation products of chlorophylls.JAM and MH thank MCYT for FPI grants. Authors thank MCYT (project AGL2002-04621-\ud
C02-02) for financial support.Peer reviewe
Online preconcentration of arsenic compounds by dynamic pH junction-capillary electrophoresis

An online preconcentration technique by dynamic pH junction was studied to improve the detection limit for anionic arsenic compounds by CE. The main target compound is roxarsone, or 3-nitro-4-hydroxyphenylarsonic acid, which is being used as an animal feed additive. The other inorganic and organoarsenic compounds studied are the possible biotransformation products of roxarsone. The arsenic species were separated by a dynamic pH junction in a fused-silica capillary using 15 mM phosphate buffer (pH 10.6) as the BGE and 15 mM acetic acid as the sample matrix. CE with UV detection was monitored at a wavelength of 192 nm. The influence of buffer pH and concentration on dynamic pH junction were investigated. The arsenic species focusing resulted in LOD improvement by a factor of 100â€“ 800. The combined use of C18 and anion exchange SPE and dynamic pH junction to CE analysis of chicken litter and soils helps to increase the detection sensitivity. Recoveries of spiked samples ranged between 70 and 72%