pinecone/core-2020-05-10-deduplication huggingface dataset:
Peganum harmala L.'s anti-growth effect on a breast cancer cell line

This research was done to evaluate the induction of apoptosis in MDA-MB-231 breast cancer cell line by Peganum harmala's extract, in which a significant amount of β-carbolines is included. The apoptosis incidence was assessed through Annexin-V-Flous kit. The expressions of genes through which intrinsic apoptosis pathway are involved, Bax, Bcl-2, Bid, and Puma, over the genes the expressions of which are linked to extrinsic apoptosis pathway, TRAIL, Caspase8, p21, and p53, were examined by RT-PCR and Real-time PCR. The results demonstrate that the extract decreases the growth rate of the cancer cell line through inducing apoptosis mechanism. As long as the expression of anti-apoptosis Bcl-2 gen reduced dramatically, an over-expression in Bax and Puma genes was monitored indicating activation of intrinsic apoptosis pathway. A notable over-expression observed with TRAIL and Caspase8 genes as well as Bid gene. The latter is an intermediate for both intrinsic and extrinsic pathways of apoptosis. © 2015 The Author
Functional integral construction of the massive Thirring model: Verification of axioms and massless limit

We present a complete construction of a Quantum Field Theory for the Massive Thirring model by following a functional integral approach. This is done by introducing an ultraviolet and an infrared cutoff and by proving that, if the "bare" parameters are suitably chosen, the Schwinger functions have a well defined limit satisfying the Osterwalder-Schrader axioms, when the cutoffs are removed. Our results, which are restricted to weak coupling, are uniform in the value of the mass. The control of the effective coupling (which is the main ingredient of the proof) is achieved by using the Ward Identities of the massless model, in the approximated form they take in the presence of the cutoffs. As a byproduct, we show that, when the cutoffs are removed, the Ward Identities have anomalies which are not linear in the bare coupling. Moreover, we find for the interacting propagator of the massless theory a closed equation which is different from that usually stated in the physical literature
Stacked Bayesian general Lomb-Scargle periodogram : identifying stellar activity signals

The research leading to these results received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number 313014 (ETAEARTH). ACC acknowledges support from STFC grant ST/M001296/1.Context. Distinguishing between a signal induced by either stellar activity or a planet is currently the main challenge in radial velocity searches for low-mass exoplanets. Even when the presence of a transiting planet and hence its period are known, stellar activity can be the main barrier to measuring the correct amplitude of the radial velocity signal. Several tools are being used to help understand which signals come from stellar activity in the data. Aims. We aim to present a new tool that can be used for the purpose of identifying periodicities caused by stellar activity, and show how it can be used to track the signal-to-noise ratio (SNR) of the detection over time. The tool is based on the principle that stellar activity signals are variable and incoherent. Methods. We calculate the Bayesian general Lomb-Scargle periodogram for subsets of data and by adding one extra data point we track what happens to the presence and significance of periodicities in the data. Publicly available datasets from HARPS and HARPS-N were used for this purpose. Additionally, we analysed a synthetic dataset that we created with SOAP2.0 to simulate pure stellar activity and a mixture of stellar activity and a planet. Results. We find that this tool can easily be used to identify unstable and incoherent signals, such as those introduced by stellar activity. The SNR of the detection grows approximately as the square root of the number of data points, in the case of a stable signal. This can then be used to make decisions on whether it is useful to keep observing a specific object. The tool is relatively fast and easy to use, and thus lends itself perfectly to a quick analysis of the data.PostprintPeer reviewe
A Comprehensive Framework for Studying $W'$ and $Z'$ Bosons at Hadron
  Colliders with Automated Jet Veto Resummation

The production of high-mass, color-singlet particles in hadron colliders is
universally accompanied by initial state QCD radiation that is predominantly
soft with respect to the hard process scale $Q$ and/or collinear with respect
to the beam axis. At TeV-scale colliders, this is in contrast to top quark and
multijet processes, which, by definition, are hard and central. Consequently,
vetoing events with jets possessing transverse momenta above $p_T^{\rm Veto}$
in searches for new color-singlet states can efficiently reduce non-singlet
backgrounds, thereby increasing experimental sensitivity. To quantify this
generic observation, we investigate the production and leptonic decay of a
Sequential Standard Model $W'$ boson at the 13 TeV LHC. We systematically
consider signal and background processes at next-to-leading-order (NLO) in QCD
with parton shower (PS) matching; for color-singlet channels, we resum Sudakov
logarithms of the form $\alpha_s^j(p_T^{\rm Veto})\log^k(Q/p_T^{\rm Veto})$ up
to next-to-next-to-leading logarithmic accuracy (NNLL) with NLO matching. We
obtain our results using the MadGraph5aMC@NLO and MadGraph5aMC@NLO-SCET
frameworks, respectively. Associated FeynRules model files capable of handling
NLO+PS- and NLO+NNLL-accurate computations are publicly available. We find that
within their given uncertainties, both the NLO+PS and NLO+NNLL(veto)
calculations give accurate and consistent predictions. Consequently, jet vetoes
applied to color-singlet processes can be reliably modeled at the NLO+PS level.
With respect to a $b$-jet veto of $p_{T}^{\rm Veto} = 30$ GeV, flavor-agnostic
vetoes of $p_{T}^{\rm Veto} = 30-40$ GeV can further reduce single top and
$t\overline{t}$ rates by a factor of 2-50 at a mild cost of the signal rate.
Jet vetoes can increase signal-to-noise ratios by roughly 10\% for light $W'$
boson masses of 30-50 GeV and 25\%-250\% for masses of 300-800 GeV.Comment: Journal version (very minor changes and updated references).
  FeynRules files available from:
  http://feynrules.irmp.ucl.ac.be/wiki/WZPrimeAtNL
Modeling and Analysis of Wireless "Charge While Driving" Operations for Fully Electric Vehicles

Abstract This study presents a method for analysing the traffic and electric performance of wireless Charge While Driving (CWD) systems for two types of electric vehicle: a light-van for freight distribution and a city car. After performing a preliminary design of the \{CWD\} system, a simplified traffic simulation, including an energy assessment for vehicles, is presented to test the design settings, such as the travelling speed on \{CWD\} and the percentage of equipped lanes. The speed range explored refers to quite low values because the design layout of the \{EVSE\} should be a compromise between the need to minimize the installation and maintenance costs and users' acceptance of the time required to obtain a proper recharge. The choice of the traffic modelling approach derives from the specific requirements of the \{CWD\} system defined in the eCo-FEV project, which may be assumed as having been installed along a low speed lane of a motorway. The simplified traffic model simulates the vehicles time series along the road, introducing their energy needs as an influencing factor of drivers' behaviour. The simulated scenarios involve electric light-vans travelling along a 5-km highway that have the opportunity to charge in motion if their State of Charge (SOC) is under an established threshol
A single-mode external cavity diode laser using an intra-cavity atomic Faraday filter with short-term linewidth <400 kHz and long-term stability of <1 MHz.

We report on the development of a diode laser system - the “Faraday laser” - using an atomic Faraday filter as the frequency-selective element. In contrast to typical external-cavity diode laser systems which offer tunable output frequency but require additional control systems in order to achieve a stable output frequency, our system only lases at a single frequency, set by the peak transmission frequency of the internal atomic Faraday filter. Our system has both short-term and long-term stability of less than 1 MHz, which is less than the natural linewidth of alkali-atomic D-lines, making similar systems suitable for use as a “turn-key” solution for laser-cooling experiments
Search for R-parity violating decays of a top squark in proton–proton collisions at s=8 TeV

© 2016 The Author(s)The results of a search for a supersymmetric partner of the top quark (top squark), pair-produced in proton–proton collisions at s=8 TeV, are presented. The search, which focuses on R-parity violating, chargino-mediated decays of the top squark, is performed in final states with low missing transverse momentum, two oppositely charged electrons or muons, and at least five jets. The analysis uses a data sample corresponding to an integrated luminosity of 19.7 fb−1 collected with the CMS detector at the LHC in 2012. The data are found to be in agreement with the standard model expectation, and upper limits are placed on the top squark pair production cross section at 95% confidence level. Assuming a 100% branching fraction for the top squark decay chain, t˜→tχ˜1±,χ˜1±→ℓ±+jj, top squark masses less than 890 (1000) GeV for the electron (muon) channel are excluded for the first time in models with a single nonzero R-parity violating coupling λijk′ (i,j,k≤2), where i,j,k correspond to the three generations
Origin and insertion of the medial patellofemoral ligament: a systematic review of anatomy

Purpose: The Medial Patellofemoral Ligament (MPFL) is the major medial soft-tissue stabiliser of the patella, originating from the medial femoral condyle and inserting onto the medial patella. The exact position reported in the literature varies. Understanding the true anatomical origin and insertion of the MPFL is critical to successful reconstruction. The purpose of this systematic review was to determine these locations. Methods: A systematic search of published (AMED, CINAHL, MEDLINE, EMBASE, PubMed and Cochrane Library) and unpublished literature databases was conducted from their inception to the 3rd February 2016. All papers investigating the anatomy of the MPFL were eligible. Methodological quality was assessed using a modified CASP tool. A narrative analysis approach was adopted to synthesise the findings. Results: After screening and review of 2045 papers, a total of studies investigating the relevant anatomy were included. From this, the origin appears to be from an area rather than (as previously reported) a single point on the medial femoral condyle. The weighted average length was 56mm with an ‘hourglass’ shape, fanning out at both ligament ends. Conclusion: The MPFL is an hourglass shaped structure running from a triangular space between the adductor tubercle, medial femoral epicondyle and gastrocnemius tubercle and inserts onto the superomedial aspect of the patella. Awareness of anatomy is critical for assessment, anatomic repair and successful surgical patellar stabilisation
6d holographic anomaly match as a continuum limit.

An infinite class of analytic AdS7 × S3 solutions has recently been found. The S3 is distorted into a “crescent roll” shape by the presence of D8-branes. These solutions are conjectured to be dual to a class of “linear quivers”, with a large number of gauge groups coupled to (bi-)fundamental matter and tensor fields. In this paper we perform a precise quantitative check of this correspondence, showing that the a Weyl anomalies computed in field theory and gravity agree. In the holographic limit, where the number of gauge groups is large, the field theory result is a quadratic form in the gauge group ranks involving the inverse of the AN Cartan matrix C. The agreement can be understood as a continuum limit, using the fact that C is a lattice analogue of a second derivative. The discrete data of the field theory, summarized by two partitions, become in this limit the continuous functions in the geometry. Conversely, the geometry of the internal space gets discretized at the quantum level to the discrete data of the two partitions
Search for events with large missing transverse momentum, jets, and at least two tau leptons in 7 TeV proton–proton collision data with the ATLAS detector

A search for events with large missing transverse momentum, jets, and at least two tau leptons has been performed using 2 fb[superscript −1] of proton–proton collision data at √s = 7 TeV recorded with the ATLAS detector at the Large Hadron Collider. No excess above the Standard Model background expectation is observed and a 95% CL upper limit on the visible cross section for new phenomena is set, where the visible cross section is defined by the product of cross section, branching fraction, detector acceptance and event selection efficiency. A 95% CL lower limit of 32 TeV is set on the gauge-mediated supersymmetry breaking (GMSB) scale Λ independent of tan β. These limits provide the most stringent tests to date in a large part of the considered parameter space.European Organization for Nuclear ResearchUnited States. Dept. of EnergyNational Science Foundation (U.S.)Brookhaven National Laborator
Performance of jet substructure techniques for large-R jets in proton-proton collisions at root s = 7 TeV using the ATLAS detector

This paper presents the application of a variety of techniques to study jet substructure. The performance of various modified jet algorithms, or jet grooming techniques, for several jet types and event topologies is investigated for jets with transverse momentum larger than 300 GeV. Properties of jets subjected to the mass-drop filtering, trimming, and pruning algorithms are found to have a reduced sensitivity to multiple proton-proton interactions, are more stable at high luminosity and improve the physics potential of searches for heavy boosted objects. Studies of the expected discrimination power of jet mass and jet substructure observables in searches for new physics are also presented. Event samples enriched in boosted W and Z bosons and top-quark pairs are used to study both the individual jet invariant mass scales and the efficacy of algorithms to tag boosted hadronic objects. The analyses presented use the full 2011 ATLAS dataset, corresponding to an integrated luminosity of 4.7 ± 0.1 fb⁻¹ from proton-proton collisions produced by the Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV.G. Aad ... P. Jackson ... L. Lee ... A. Petridis ... N. Soni ... M.J. White ... et al. (The ATLAS Collaboration
Search for an Isospin I =3 Dibaryon

Various theoretical calculations based on QCD or hadronic interactions predict that in addition to the recently observed dibaryon resonance $d^*(2380)$ with $I(J^P) = 0(3^+)$ there should also exist a dibaryon resonance with mirrored quantum numbers $I(J^P) = 3(0^+)$. We report here on a search for such a $NN$-decoupled state in data on the $pp \to pp\pi^+\pi^+\pi^-\pi^-$ reaction. Since no clear-cut evidence has been found, we give upper limits for the production cross section of such a resonance in the mass range 2280 - 2500 MeV
Measurement of the tt¯ production cross-section using eμ events with b-tagged jets in pp collisions at √s=13TeV with the ATLAS detector

This paper describes a measurement of the inclusive top quark pair production cross-section (View the MathML sourceσtt¯) with a data sample of View the MathML source3.2fb−1 of proton–proton collisions at a centre-of-mass energy of View the MathML sources=13TeV, collected in 2015 by the ATLAS detector at the LHC. This measurement uses events with an opposite-charge electron–muon pair in the final state. Jets containing b-quarks are tagged using an algorithm based on track impact parameters and reconstructed secondary vertices. The numbers of events with exactly one and exactly two b  -tagged jets are counted and used to determine simultaneously View the MathML sourceσtt¯ and the efficiency to reconstruct and b-tag a jet from a top quark decay, thereby minimising the associated systematic uncertainties. The cross-section is measured to be:View the MathML sourceσtt¯=818±8(stat)±27(syst)±19(lumi)±12(beam) pb,Turn MathJax onwhere the four uncertainties arise from data statistics, experimental and theoretical systematic effects, the integrated luminosity and the LHC beam energy, giving a total relative uncertainty of 4.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. A fiducial measurement corresponding to the experimental acceptance of the leptons is also presented
Properties of the Michaelis–Menten mechanism in phase space

AbstractWe study the two-dimensional reduction of the Michaelis–Menten reaction of enzyme kinetics. First, we prove the existence and uniqueness of a slow manifold between the horizontal and vertical isoclines. Second, we determine the concavity of all solutions in the first quadrant. Third, we establish the asymptotic behaviour of all solutions near the origin, which generally is not given by a Taylor series. Finally, we determine the asymptotic behaviour of the slow manifold at infinity. To this end, we show that the slow manifold can be constructed as a centre manifold for a fixed point at infinity
Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex

SummaryGentamicin C complex is a mixture of aminoglycoside antibiotics used worldwide to treat severe Gram-negative bacterial infections. Despite its clinical importance, the enzymology of its biosynthetic pathway has remained obscure. We report here insights into the four enzyme-catalyzed steps that lead from the first-formed pseudotrisaccharide gentamicin A2 to gentamicin X2, the last common intermediate for all components of the C complex. We have used both targeted mutations of individual genes and reconstitution of portions of the pathway in vitro to show that the secondary alcohol function at C-3″ of A2 is first converted to an amine, catalyzed by the tandem operation of oxidoreductase GenD2 and transaminase GenS2. The amine is then specifically methylated by the S-adenosyl-l-methionine (SAM)-dependent N-methyltransferase GenN to form gentamicin A. Finally, C-methylation at C-4″ to form gentamicin X2 is catalyzed by the radical SAM-dependent and cobalamin-dependent enzyme GenD1
New inhomogeneous Einstein metrics on sphere bundles over Einstein–Kähler manifolds

AbstractWe construct new complete, compact, inhomogeneous Einstein metrics on Sm+2 sphere bundles over 2n-dimensional Einstein–Kähler spaces K2n, for all n⩾1 and all m⩾1. We also obtain complete, compact, inhomogeneous Einstein metrics on warped products of Sm with S2 bundles over K2n, for m>1. Additionally, we construct new complete, non-compact Ricci-flat metrics with topologies Sm times R2 bundles over K2n that generalise the higher-dimensional Taub-BOLT metrics, and with topologies Sm×R2n+2 that generalise the higher-dimensional Taub-NUT metrics, again for m>1
A-stable Runge–Kutta methods for semilinear evolution equations

AbstractWe consider semilinear evolution equations for which the linear part generates a strongly continuous semigroup and the nonlinear part is sufficiently smooth on a scale of Hilbert spaces. In this setting, we prove the existence of solutions which are temporally smooth in the norm of the lowest rung of the scale for an open set of initial data on the highest rung of the scale. Under the same assumptions, we prove that a class of implicit, A-stable Runge–Kutta semidiscretizations in time of such equations are smooth as maps from open subsets of the highest rung into the lowest rung of the scale. Under the additional assumption that the linear part of the evolution equation is normal or sectorial, we prove full order convergence of the semidiscretization in time for initial data on open sets. Our results apply, in particular, to the semilinear wave equation and to the nonlinear Schrödinger equation
UV–IR mixing in non-commutative plane

AbstractPoincaré-invariant quantum field theories can be formulated on non-commutative planes if the coproduct on the Poincaré group is suitably deformed. As shown in our previous work, this important result implies modification of free field commutation and anti-commutation relations and striking phenomenological consequences such as violations of Pauli principle. In this Letter we prove that with these modifications, UV–IR mixing disappears to all orders in perturbation theory from the S-matrix. This result is in agreement with the previous results of Oeckl
The effects of an insertion in the 5′UTR of the AMCase on gene expression and pulmonary functions

SummaryBackgroundStudies regarding the physiological role of acidic mammalian chitinase (AMCase) and the effects of its genetic variants on asthma have produced conflicting results.ObjectivesWe aimed to determine the genetic variants in the AMCase gene that could regulate the gene expression and thus influence disease severity.MethodsGenetic variants of the AMCase gene were determined by sequencing of asthmatics and healthy controls in up to −1 kb in the promoter region and exon 1 and 2. In an association study, a population of asthmatic (n = 504) and healthy Turkish children (n = 188) were genotyped for the observed SNPs. A replication study was performed in a North American adult population of patients with mild (n = 317) and severe (n = 145) asthma. The functional properties of the insertion were determined by promoter reporter assay, electromobility shift assay and transcription factor ELISA experiments.ResultsOf the identified SNPs, only a ten base pair insertion (CAATCTAGGC) in the 5′UTR region of exon 2 was significantly associated with lower FEV1 (β = −14.63 SE = 6.241, P = 0.019) in Turkish children with asthma. However, in the adult population, the same insertion showed a trend toward higher FEV1. The insertion was shown to have enhancer activity and the mutant probe possessing the insertion had higher binding affinity for the nuclear extracts.ConclusionOur study shows that a ten base pair insertion in the 5′UTR region of AMCase gene may modify gene expression and thus may affect the severity of asthma. However, its effects appear to be different in different populations
Conformal Newton–Hooke algebras, Niederer's transformation and Pais–Uhlenbeck oscillator

AbstractDynamical systems invariant under the action of the l-conformal Newton–Hooke algebras are constructed by the method of nonlinear realizations. The relevant first order Lagrangians together with the corresponding Hamiltonians are found. The relation to the Galajinsky and Masterov [24] approach as well as the higher derivatives formulation is discussed. The generalized Niederer's transformation is presented which relates the systems under consideration to those invariant under the action of the l-conformal Galilei algebra [25]. As a nice application of these results an analogue of Niederer's transformation, on the Hamiltonian level, for the Pais–Uhlenbeck oscillator is constructed