pinecone/core-2020-05-10-deduplication huggingface dataset:
Simulations of magnetized multiphase galactic disc regulated   by supernovae explosions

International audienceContext. What exactly controls star formation in the Galaxy remains controversial. In particular, the role of feedback and magnetic field are still partially understood.Aims. We investigate the role played by supernovae feedback and magnetic field on the star formation and the structure of the Galactic disc. Methods. We perform numerical simulations of the turbulent, magnetized, self-gravitating, multi-phase, supernovae regulated ISM within a 1 kpc stratified box. We implemented various schemes for the supernovae. This goes from a random distribution at a fixed rate to distributions for which the supernovae are spatially and temporally correlated to the formation of stars. To study the influence of magnetic field on star formation, we perform both hydrodynamical and magneto-hydrodynamical simulations. Results. We find that supernovae feedback has a drastic influence on the galactic evolution. The supernovae distribution plays a very significant role. When the supernovae are not correlated with star formation events, they do not significantly modify the very high star formation rate obtained without feedback. When the supernovae follow the accretion, the star formation rate can be reduced by a factor up to 30. The magnetic field is also playing a significant role. It reduces the star formation rate by a factor up to 2−3 and reduces the number of collapse sites by a factor of about 2. Conclusions. The exact correlation between the supernovae and the dense gas appears to have significant consequences on the galactic disc evolution and the star formation. This implies that small scale studies are necessary to understand and quantify the feedback efficiency. The magnetic field does influence the star formation at galactic scales by reducing the star formation rate and the number of star formation sites
Dumbing down rational players: Learning and teaching in an experimental game

International audienceThis paper uses experimental data to examine the existence of a teaching strategy among boundedly rational players. If players realize that their own actions modify their opponents' beliefs and actions, they might play certain actions to this specific end and forego immedi- ate payoffs if the expected payoff gain from a teaching strategy is high enough. Our results support the existence of a teaching strategy in several ways. After exhibiting some regular- ities consistent with teaching, we examine more precisely the existence of such a strategy. First we show that players update their beliefs in order to take account of the reaction of their opponents to their own action. Second, we examine whether players actually use a teaching strategy by playing an action that induces a poor immediate payoff but is likely to modify the opponent's behavior so that a preferable outcome might emerge in the future. We find strong evidence of such a strategy in the data and confirm this finding within a logistic model that suggests that the future expected payoff that could arise from a teach- ing strategy has indeed a significant impact on choice probabilities. Finally, we investigate the effective impact of a teaching strategy on achieved outcomes and find that more tena- cious teachers can successfully use such a strategy in order to reach their favorite outcome at the expense of their opponents
MULTIWAVELENGTH OBSERVATIONS OF 3C 454.3. II. THE AGILE 2007 DECEMBER CAMPAIGN

We report on the second Astrorivelatore Gamma a Immagini Leggero (AGILE) multiwavelength campaign of the blazar 3C 454.3 during the first half of 2007 December. This campaign involved AGILE, Spitzer, Swift, Suzaku, the Whole Earth Blazar Telescope (WEBT) consortium, the Rapid Eye Mount (REM), and the Multicolor Imaging Telescopes for Survey and Monstrous Explosions (MITSuME) telescopes, offering a broadband coverage that allowed for a simultaneous sampling of the synchrotron and inverse Compton (IC) emissions. The two-week AGILE monitoring was accompanied by radio to optical monitoring by WEBT and REM, and by sparse observations in mid-infrared and soft/ hard X-ray energy bands performed by means of Target of Opportunity observations by Spitzer, Swift, and Suzaku, respectively. The source was detected with an average flux of similar to 250 x 10(-8) photons cm(-2) s(-1) above 100 MeV, typical of its flaring states. The simultaneous optical and gamma-ray monitoring allowed us to study the time lag associated with the variability in the two energy bands, resulting in a possible <= one-day delay of the gamma-ray emission with respect to the optical one. From the simultaneous optical and gamma-ray fast flare detected on December 12, we can constrain the delay between the gamma-ray and optical emissions within 12 hr. Moreover, we obtain three spectral energy distributions (SEDs) with simultaneous data for 2007 December 5, 13, and 15, characterized by the widest multifrequency coverage. We found that a model with an external Compton on seed photons by a standard disk and reprocessed by the broad-line regions does not describe in a satisfactory way the SEDs of 2007 December 5, 13, and 15. An additional contribution, possibly from the hot corona with T = 10(6) K surrounding the jet, is required to account simultaneously for the softness of the synchrotron and the hardness of the IC emissions during those epochs
Measurement of the pp -> ZZ production cross section and constraints on anomalous triple gauge couplings in four-lepton final states at sqrt(s) = 8 TeV

A measurement of the inclusive ZZZZ production cross section and constraints on anomalous triple gauge couplings in proton–proton collisions at View the MathML sources=8 TeV are presented. The analysis is based on a data sample, corresponding to an integrated luminosity of 19.6 fb−119.6 fb−1, collected with the CMS experiment at the LHC. The measurements are performed in the leptonic decay modes ZZ→ℓℓℓ′ℓ′ZZ→ℓℓℓ′ℓ′, where ℓ=e,μℓ=e,μ and ℓ′=e,μ,τℓ′=e,μ,τ. The measured total cross section View the MathML sourceσ(pp→ZZ)=7.7±0.5 (stat)−0.4+0.5 (syst)±0.4(theo)±0.2 (lumi) pb, for both Z bosons produced in the mass range 60<mZ<120 GeV60<mZ<120 GeV, is consistent with standard model predictions. Differential cross sections are measured and well described by the theoretical predictions. The invariant mass distribution of the four-lepton system is used to set limits on anomalous ZZZZZZ and ZZγZZγ couplings at the 95% confidence level: View the MathML source−0.004<f4Z<0.004, View the MathML source−0.004<f5Z<0.004, View the MathML source−0.005<f4γ<0.005, and View the MathML source−0.005<f5γ<0.005
Expanding the Phenotype Associated with NAA10 Related N-terminal Acetylation Deficiency

International audienceN-terminal acetylation is a common protein modification in eukaryotes associated with numerous cellular processes. Inherited mutations in NAA10, encoding the catalytic subunit of the major N-terminal acetylation complex NatA have been associated with diverse, syndromic X-linked recessive disorders, whereas de novo missense mutations have been reported in one male and one female individual with severe intellectual disability but otherwise unspecific phenotypes. Thus, the full genetic and clinical spectrum of NAA10 deficiency is yet to be delineated. We identified three different novel and one known missense mutation in NAA10, de novo in 11 females, and due to maternal germ line mosaicism in another girl and her more severely affected and deceased brother. In vitro enzymatic assays for the novel, recurrent mutations p.(Arg83Cys) and p.(Phe128Leu) revealed reduced catalytic activity. X-inactivation was random in five females. The core phenotype of X-linked NAA10-related N-terminal-acetyltransferase deficiency in both males and females includes developmental delay, severe intellectual disability, postnatal growth failure with severe microcephaly, and skeletal or cardiac anomalies. Genotype–phenotype correlations within and between both genders are complex and may include various factors such as location and nature of mutations, enzymatic stability and activity, and X-inactivation in females
Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5

BACKGROUND AND PURPOSE:\ud
Chronic inflammatory conditions, such as granulomas, are associated with angiogenesis. Mast cells represent the main cell type orchestrating angiogenesis, through the release of their granule content. Therefore, compounds able to modulate mast cell behaviour may be considered as a new pharmacological approach to treat angiogenesis-dependent events. Here, we tested the effect of selective cannabinoid (CB) receptor agonists in a model of angiogenesis-dependent granuloma formation induced by lambda-carrageenin in rats.\ud
EXPERIMENTAL APPROACH:\ud
Granulomas were induced by lambda-carrageenin-soaked sponges implanted subcutaneously on the back of male Wistar rats. After 96 h, implants were removed and granuloma formation was measured (wet weight); angiogenesis was evaluated by histological analysis and by the measurement of haemoglobin content. Mast cells in the granulomas were evaluated histologically and by RT-PCR and immunoblotting analysis for mast cell-derived proteins (rat mast cell protease-5 (rMCP-5) and nerve growth factor). Selective CB1 and CB2 receptor agonists(,) ACEA and JWH-015 (0.001-0.1 mg mL(-1)), were given locally only once, at the time of implantation.\ud
KEY RESULTS:\ud
The CB1 and CB2 receptor agonists decreased the weight and vascularization of granulomas after 96 h. This treatment also reduced mast cell number and activation in granulomatous tissue. Specifically, these compounds prevented the transcription and expression of rMCP-5, a protein involved in sprouting and advance of new blood vessels.\ud
CONCLUSION AND IMPLICATIONS:\ud
Modulation of mast cell function by cannabinoids reduced granuloma formation and associated angiogenesis. Therefore cannabinoid-related drugs may be useful in the management of granulomatous diseases accompanied by angiogenesis
VirtualECare : group support in collaborative networks organizations for digital homecare

Collaborative Work plays an important role in today’s organizations and normally in areas
where decisions must be made. However, any decision that involves a collective or group of
decision makers is, by itself, complex but is becoming normal in recent years. In this work we
present the VirtualECare project (Figure 10), intelligent multi‐agent system able to monitor,
interact and serve its customers, which are, normally, in need of care services.
In the last years there has been a substantially increase in the number of people needed of
intensive care, especially among the elderly, a phenomenon that is related to population
ageing. However, this is not exclusive of the elderly, as diseases as obesity, diabetes, and blood
pressure have been increasing among young adults. As a new reality, it has to be dealt by the
health sector, and particularly by the public one. Thus, the importance of finding new and cost
effective ways for health care delivery are of particular importance, especially when one want
them not to be removed from their “habitat”. Following this line of thinking, the VirtualECare
project will be presented, like similar ones that preceded it.
Recently we have assisted to a growing interest in combining the advances in information
society ‐ computing, telecommunications and presentation – in order to create Group Decision
Support Systems (GDSS). Indeed, the new economy, along with increased competition in
today’s complex business environments, takes the companies to seek complementarities in
order to increase competitiveness and reduce risks. Under these scenarios, planning takes a
major role in a company life. However, effective planning depends on the generation and
analysis of ideas (innovative or not) and, as a result, the idea generation and management
processes are crucial.
Our objective is to apply the above presented GDSS to a new area. We believe that the use of
GDSS in the healthcare arena will allow professionals to achieve better results in the analysis of
one’s Electronically Clinical Profile (ECP). This achievement is vital, regarding the explosion of
knowledge and skills, together with the need to use limited resources and get better results
Search for long-lived, multi-charged particles in pp collisions at s√=7 TeV using the ATLAS detector

A search for highly ionising, penetrating particles with electric charges from |q| = 2e to 6e is performed
using the ATLAS detector at the CERN Large Hadron Collider. Proton–proton collision data taken
at √s = 7 TeV during the 2011 running period, corresponding to an integrated luminosity of 4.4 fb−1,
are analysed. No signal candidates are observed, and 95% confidence level cross-section upper limits are
interpreted as mass-exclusion lower limits for a simplified Drell–Yan production model. In this model,
masses are excluded from 50 GeV up to 430, 480, 490, 470 and 420 GeV for charges 2e, 3e, 4e, 5e and
6e, respectively.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; EPLANET, ERC and NSRF, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT and NSRF, Greece; ISF, MINERVA, GIF, DIP and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; BRF and RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America
Kaon mixing beyond the SM from N-f=2 tmQCD and model independent constraints from the UTA

We present the first unquenched, continuum limit, lattice QCD results for the matrix elements of the operators describing neutral kaon oscillations in extensions of the Standard Model. Owing to the accuracy of our calculation on Delta S = 2 weak Hamiltonian matrix elements, we are able to provide a refined Unitarity Triangle analysis improving the bounds coming from model independent constraints on New Physics. In our non-perturbative computation we use a combination of N-f = 2 maximally twisted sea quarks and Osterwalder-Seiler valence quarks in order to achieve both O(a)-improvement and continuum-like renormalization properties for the relevant four-fermion operators. The calculation of the renormalization constants has been performed non-perturbatively in the RI-MOM scheme. Based on simulations at four values of the lattice spacing and a number of quark masses we have extrapolated/interpolated our results to the continuum limit and physical light/strange quark masses
Up, down, strange and charm quark masses with N-f=2+1+1 twisted mass lattice QCD

We present a lattice QCD calculation of the up, down, strange and charm quark masses performed using the gauge configurations produced by the European Twisted Mass Collaboration with N-f = 2 + 1 + 1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their physical values. The simulations are based on a unitary setup for the two light quarks and on a mixed action approach for the strange and charm quarks. The analysis uses data at three values of the lattice spacing and pion masses in the range 210-450 MeV, allowing for accurate continuum limit and controlled chiral extrapolation. The quark mass renormalization is carried out non-perturbatively using the RI'-MOM method. The results for the quark masses converted to the (MS) over bar scheme are: m(ud) (2 GeV) = 3.70(17) MeV, m(s)(2 GeV) = 99.6(4.3) MeV and m(c)(m(c)) = 1.348(46) GeV. We obtain also the quark mass ratios m(s)/m(ud) = 26.66(32) and m(c)/m(s) = 11.62(16). By studying the mass splitting between the neutral and charged kaons and using available lattice results for the electromagnetic contributions, we evaluate m(u)/m(d) = 0.470(56), leading to m(u) = 2.36(24) MeV and m(d) = 5.03(26) MeV
Search for a new gauge boson in pi(0) decays

A search was made for a new light gauge boson X which might be produced in pi(0) -->, gamma + X decay from neutral pions generated by 450 GeV protons in the CERN SPS neutrino target. The X's would penetrate the downstream shielding and be observed in the NOMAD detector via the Primakoff effect, in the process of X --> pi(0) conversion in the external Coulomb field of a nucleus. With 1.45 x 10(18) protons on target, 20 candidate events with energy between 8 and 140 GeV were found from the analysis of neutrino data. This number is in agreement with the expectation of 18.1 +/- 2.8 background events from standard neutrino processes. A new 90% C.L. upper limit on the branching ratio Br(pi(0) --> Y + X)< (3.3 to 1.9)X 10(-5) for X masses ranging from 0 to 120 MeV/c(2) is obtained
The impact of iron limitation on the physiology of the Antarctic diatom Chaetoceros simplex

Iron availability strongly governs the growth of Southern Ocean phytoplankton. To investigate how iron limitation affects photosynthesis as well as the uptake of carbon and iron in the Antarctic diatom Chaetoceros simplex, a combination of chlorophyll a fluorescence measurements and radiotracer incubations in the presence and absence of chemical inhibitors was conducted. Iron limitation in C. simplex led to a decline in growth rates, photochemical efficiency and structural changes in photosystem II (PSII), including a reorganisation of photosynthetic units in PSII and an increase in size of the functional absorption cross section of PSII. Iron-limited cells further exhibited a reduced plastoquinone pool and decreased photosynthetic electron transport rate, while non-photochemical quenching and relative xanthophyll pigment content were strongly increased, suggesting a photoprotective response. Additionally, iron limitation resulted in a strong decline in carbon fixation and thus the particulate organic carbon quotas. Inhibitor studies demonstrated that, independent of the iron supply, carbon fixation was dependent on internal, but not on extracellular carbonic anhydrase activity. Orthovanadate more strongly inhibited iron uptake in iron-limited cells, indicating that P-type ATPase transporters are involved in iron uptake. The stronger reduction in iron uptake by ascorbate in iron-limited cells suggests that the re-oxidation of iron is required before it can be taken up and further supports the presence of a high-affinity iron transport pathway. The measured changes to photosystem architecture and shifts in carbon and iron uptake strategies in C. simplex as a result of iron limitation provide evidence for a complex interaction of these processes to balance the iron requirements for photosynthesis and carbon demand for sustained growth in iron-limited waters
Fluid challenges in intensive care : the FENICE study A global inception cohort study

Fluid challenges (FCs) are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in intensive care units. There are clear benefits and harms from fluid therapy. Limited data on the indication, type, amount and rate of an FC in critically ill patients exist in the literature. The primary aim was to evaluate how physicians conduct FCs in terms of type, volume, and rate of given fluid; the secondary aim was to evaluate variables used to trigger an FC and to compare the proportion of patients receiving further fluid administration based on the response to the FC. 
This was an observational study conducted in ICUs around the world. Each participating unit entered a maximum of 20 patients with one FC. 
2213 patients were enrolled and analyzed in the study. The median [interquartile range] amount of fluid given during an FC was 500 ml (500-1000). The median time was 24 min (40-60 min), and the median rate of FC was 1000 [500-1333] ml/h. The main indication for FC was hypotension in 1211 (59 %, CI 57-61 %). In 43 % (CI 41-45 %) of the cases no hemodynamic variable was used. Static markers of preload were used in 785 of 2213 cases (36 %, CI 34-37 %). Dynamic indices of preload responsiveness were used in 483 of 2213 cases (22 %, CI 20-24 %). No safety variable for the FC was used in 72 % (CI 70-74 %) of the cases. There was no statistically significant difference in the proportion of patients who received further fluids after the FC between those with a positive, with an uncertain or with a negatively judged response. 
The current practice and evaluation of FC in critically ill patients are highly variable. Prediction of fluid responsiveness is not used routinely, safety limits are rarely used, and information from previous failed FCs is not always taken into account
Combination of searches for WW, WZ, and ZZ resonances in pp collisions at s=8 TeV with the ATLAS detector

The ATLAS experiment at the CERN Large Hadron Collider has performed searches for new, heavy bosons decaying to WW, WZ and ZZ   final states in multiple decay channels using 20.3 fb−120.3 fb−1 of pp   collision data at View the MathML sources=8 TeV. In the current study, the results of these searches are combined to provide a more stringent test of models predicting heavy resonances with couplings to vector bosons. Direct searches for a charged diboson resonance decaying to WZ   in the ℓνℓ′ℓ′ℓνℓ′ℓ′ (ℓ=μ,eℓ=μ,e), View the MathML sourceℓℓqq¯, View the MathML sourceℓνqq¯ and fully hadronic final states are combined and upper limits on the rate of production times branching ratio to the WZ   bosons are compared with predictions of an extended gauge model with a heavy W′W′ boson. In addition, direct searches for a neutral diboson resonance decaying to WW and ZZ   in the View the MathML sourceℓℓqq¯, View the MathML sourceℓνqq¯, and fully hadronic final states are combined and upper limits on the rate of production times branching ratio to the WW and ZZ bosons are compared with predictions for a heavy, spin-2 graviton in an extended Randall–Sundrum model where the Standard Model fields are allowed to propagate in the bulk of the extra dimension.We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States. In addition, individual groups and members have received support from BCKDF, the Canada Council, CANARIE, CRC, Compute Canada, FQRNT, and the Ontario Innovation Trust, Canada; EPLANET, ERC, FP7, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex and Idex, ANR, Region Auvergne and Fondation Partager le Savoir, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF; BSF, GIF and Minerva, Israel; BRF, Norway; the Royal Society and Leverhulme Trust, United Kingdom