pinecone/core-2020-05-10-deduplication huggingface dataset:
Student voice and the community forum: Finding ways of ‘being heard’ at an alternative school for disenfranchised young people

Opportunities for students to speak and to be heard are important elements of democratic schooling processes but research into student voice has shown that a culture of silence is a more common feature of schooling. Efforts to re‐engage young people in learning often recognise the importance of schooling processes that provide them with opportunities to participate meaningfully in schooling dialogues. This paper describes attempts to provide such opportunities for young people in an alternative school, who had been marginalised in mainstream schooling. Research was conducted over a period of 18 months, utilising a range of data collection methods, including interviews, observations, photography and the collection of artefacts, such as school documents. Drawing particularly on data related to a daily community forum, the paper explores how this routine afforded opportunities for student voice. The three‐part structure of the forum produced a range of effects, including: a discussion of issues related to local and wider community news as well as college announcements; a check‐in where each member of the community voiced their readiness (or otherwise) for the day's learning; and a sign‐up process that incorporated informed decision making about the day's learning sessions. It is argued that the intentions that underpin the community forum are important and relevant in all forms of schooling, not just alternative programmes, but these intentions can produce unintended effects.Full Tex
Curriculum differentiation and social inequality in higher education entry in Scotland and Ireland

This paper examines the relative importance of upper secondary subject choice and attainment in explaining social inequalities in access to higher education (HE) in Scotland and Ireland. These two countries differ in the extent of curriculum differentiation, in the degree of standardisation in school examination and in HE entry criteria. In particular, in Scotland subject choice in upper secondary education is more differentiated (both in terms of number and type of subjects taken) and allocation of places in HE is less standardised and more dependent upon the subjects studied at school than in Ireland. Given these institutional differences, we expected subject choices to be more important for explaining social origin differences in HE entry and access to prestigious institutions in Scotland than in Ireland. Because of increasing student competition for HE places, we further hypothesised the growing importance of school subjects over time in mediating social inequalities in HE entry in both countries, more so in Scotland than in Ireland. Our results confirm that subject choice is a stronger mediator of social inequalities in HE entry and access to prestigious universities in Scotland while attainment is more important in Ireland. Contrary to our expectations, the role of subject choice in HE entry has not become more important over time. However, in Scotland subject choice continues to be a strong mediator for social inequalities in HE entry
Higher education, graduate skills and the skills of graduates: the case of graduates as residential sales estate agents

The UK labour market is subject to significant graduatisation. Yet in the context of an over-supply of graduates, little is known about the demand for and deployment of graduate skills in previously non-graduate jobs. Moreover, there is little examination of where these skills are developed, save an assumption in higher education. Using interviews and questionnaire data from a study of British residential sales estate agents, this article explores the demand, deployment and development of graduate skills in an occupation that is becoming graduatised. These data provide no evidence to support the view that the skills demanded and deployed are those solely developed within higher education. Instead what employers require is a wide array of predominantly soft skills developed in many different situs. These findings suggest that, in the case of estate agents, what matters are the ‘skills of graduates’ rather than putative ‘graduate skills’
Conceptualising transformative undergraduate experiences:a phenomenographic exploration of students’ personal projects

Existing ways of understanding the transformative potential of students’ undergraduate experiences either focus solely on the formal educational elements of these experiences or present an overly static picture of students’ intentions in engaging in higher education. In this article we argue that the notion of ‘personal project’ offers a more flexible way of understanding what students are trying to gain from being at university. Based on a phenomenographic analysis of interviews with 31 students over the three years of their degrees, we examine how sociology students’ accounts of their personal projects develop over the three years of their degree programmes and how these relate to their accounts of their integration into their institutions and the development of their intellectual engagement with their discipline. We argue that students’ accounts of their personal projects are relatively stable over the course of their degrees but do not appear to shape the development of their intellectual engagement with their degree programme. What appears to be more significant is whether or not students understand their time at university as an educational experience. Based on this, we argue that the transformative elements of an undergraduate education lie in students developing their personal projects and intellectual engagement through the educational context that is offered at university
Supporting and inhibiting the well-being of early career secondary school teachers: extending self-determination theory

This article reports an original examination of the well-being of early career secondary school teachers in England, which extends the evidence bases relating to early career teachers’ working lives, teacher well-being, self-determination theory (Ryan &amp; Deci, 2000), and performativity (Ball, 2003), respectively. Drawing on a secondary analysis of qualitative data generated for four separate empirical studies between 2005 and 2013, in a context in which teachers’ work was subject to unparalleled external regulation, the authors examine the extent to which the well-being of early career teachers can be explained by self-determination theory, which posits that well-being is enhanced when innate psychological needs for competence, relatedness and autonomy are satisfied. The findings suggest that satisfaction of these three basic psychological needs is a necessary but not sufficient condition for optimising the well-being of early career teachers, which is dependent upon the interaction of a wider range of individual, relational and micro-, meso- and macro-environmental factors. Amongst the recommendations for policy and practice, policymakers and school leaders are urged to uphold their duty of care to newly and recently qualified teachers by doing their utmost to create conditions for the optimisation of their well-being. Several specific means of bringing this about are proposed, together with a checklist for those concerned to support early career teachers’ well-being
Supporting and inhibiting the well-being of early career secondary school teachers: extending self-determination theory

This article reports an original examination of the well-being of early career secondary school teachers in England, which extends the evidence bases relating to early career teachers’ working lives, teacher well-being, self-determination theory (Ryan & Deci, 2000), and performativity (Ball, 2003), respectively. Drawing on a secondary analysis of qualitative data generated for four separate empirical studies between 2005 and 2013, in a context in which teachers’ work was subject to unparalleled external regulation, the authors examine the extent to which the well-being of early career teachers can be explained by self-determination theory, which posits that well-being is enhanced when innate psychological needs for competence, relatedness and autonomy are satisfied. The findings suggest that satisfaction of these three basic psychological needs is a necessary but not sufficient condition for optimising the well-being of early career teachers, which is dependent upon the interaction of a wider range of individual, relational and micro-, meso- and macro-environmental factors. Amongst the recommendations for policy and practice, policymakers and school leaders are urged to uphold their duty of care to newly and recently qualified teachers by doing their utmost to create conditions for the optimisation of their well-being. Several specific means of bringing this about are proposed, together with a checklist for those concerned to support early career teachers’ well-being.  \ud
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Keywords: teacher well-being; early career teachers; self-determination theory; performativit
Governing through trust: Community-based link workers and parental engagement in education

This article seeks to further understandings of contemporary patterns of parental government. It explores the politicisation of family life by examining a pilot programme tasked with enhancing parental engagement in education amongst ‘hard-to-reach’ families within the white British community of a large inner-London borough. Focusing on the programme’s signature device – the deployment of community-based ‘link workers’ to bridge home and school – ‘governmentality’ (Foucault, 2009) is used as a theoretical lens through which to foreground the link workers’ role in governing parents. We draw on qualitative data collected from link workers, parents, and school leaders, to argue that link workers represent a mode of governmentality that privileges the instrumental use of trust to achieve strategic objectives, rather than coercive authority. The aim being to produce responsible, self-disciplined parents who act freely in accordance with normative expectations as to what constitutes ‘good’ parenting and effective parental support. As such, the article highlights the link workers’ role in (re)producing the ideal, neoliberal parent. However, governing through trust comes at the cost of being unable to firmly secure desired outcomes. We thereby conclude that this gentle art of parental government affords parents some latitude in resisting institutional agendas.Camden City Counci
Pannexins, distant relatives of the connexin family with specific cellular functions?

Intercellular communication (IC) is mediated by gap junctions (GJs) and hemichannels, which consist of proteins. This has been particularly well documented for the connexin (Cx) family. Initially, Cxs were thought to be the only proteins capable of GJ formation in vertebrates. About 10 years ago, however, a new GJ-forming protein family related to invertebrate innexins (Inxs) was discovered in vertebrates, and named the pannexin (Panx) family. Panxs, which are structurally similar to Cxs, but evolutionarily distinct, have been shown to be co-expressed with Cxs in vertebrates. Both protein families show distinct properties and have their own particular function. Identification of the mechanisms that control Panx channel gating is a major challenge for future work. In this review, we focus on the specific properties and role of Panxs in normal and pathological conditions.status: publishe
Characterization of normal and cancer stem cells: One experimental paradigm for two kinds of stem cells

International audienceThe characterization of normal stem cells and cancer stem cells uses the same paradigm. These cells are isolated by a Fluorescent-Activated Cell Sorting step and their stemness is assayed following implantation into animals. However, differences exist between these two kinds of stem cells. Therefore, the translation of the experimental procedures used for normal stem cell isolation into the cancer stem cell research field is a potential source of artefacts. In addition, normal stem cell therapy has for objective the regeneration of a tissue, while cancer stem cell-centred therapy seeks the destruction of the cancer tissue. Taking these differences into account is critical for anticipating problems that might arise in cancer stem cell-centred therapy and for upgrading the cancer stem cell paradigm accordingly
Parasite annexins - New molecules with potential for drug and vaccine development

In the last few years, annexins have been discovered in several nematodes and other parasites, and distinct differences between the parasite annexins and those of the hosts make them potentially attractive targets for anti-parasite therapeutics. Annexins are ubiquitous proteins found in almost all organisms across all kingdoms. Here, we present an overview of novel annexins from parasitic organisms, and summarize their phylogenetic and biochemical properties, with a view to using them as drug or vaccine targets. Building on structural and biological information that has been accumulated for mammalian and plant annexins, we describe a predicted additional secondary structure element found in many parasite annexins that may confer unique functional properties, and present a specific antigenic epitope for use as a vaccine.Griffith Sciences, School of Natural SciencesFull Tex
The hidden benefits of sex : evidence for MHC-associated mate choice in primate societies.

Major histocompatibility complex (MHC)-associated mate choice is thought to give offspring a fitness advantage through disease resistance. Primates offer a unique opportunity to understand MHC-associated mate choice within our own zoological order, while their social diversity provides an exceptional setting to examine the genetic determinants and consequences of mate choice in animal societies. Although mate choice is constrained by social context, increasing evidence shows that MHC-dependent mate choice occurs across the order in a variety of socio-sexual systems and favours mates with dissimilar, diverse or specific genotypes non-exclusively. Recent research has also identified phenotypic indicators of MHC quality. Moreover, novel findings rehabilitate the importance of olfactory cues in signalling MHC genes and influencing primate mating decisions. These findings underline the importance to females of selecting a sexual partner of high genetic quality, as well as the generality of the role of MHC genes in sexual selection
How ubiquitination regulates the TGF-β signalling pathway: New insights and new players

Ubiquitination of protein species in regulating signal transduction pathways is universally accepted as of fundamental importance for normal development, and defects in this process have been implicated in the progression of many human diseases. One pathway that has received much attention in this context is transforming growth factor-beta (TGF-ß) signalling, particularly during the regulation of epithelial-mesenchymal transition (EMT) and tumour progression. While E3-ubiquitin ligases offer themselves as potential therapeutic targets, much remains to be unveiled regarding mechanisms that culminate in their regulation. With this in mind, the focus of this review highlights the regulation of the ubiquitination pathway and the significance of a recently described group of NEDD4 E3-ubiquitin ligase isoforms in the context of TGF-ß pathway regulation. Moreover, we now broaden these observations to incorporate a growing number of protein isoforms within the ubiquitin ligase superfamily as a whole, and discuss their relevance in defining a new ‘iso-ubiquitinome’
No jacket required – new fungal lineage defies dress code

Analyses of environmental DNAs have provided tantalizing evidence for “rozellida” or “cryptomycota”, a clade of mostly undescribed and deeply diverging aquatic fungi. Here, we put cryptomycota into perspective through consideration of  Rozella , the only clade member growing in culture. This is timely on account of the publication in  Nature  of the first images of uncultured cryptomycota from environmental filtrates, where molecular probes revealed non‐motile cyst‐like structures and motile spores, all lacking typical fungal chitinous cell walls. Current studies of  Rozella  can complement these fragmentary observations from environmental samples.  Rozella  has a fungal‐specific chitin synthase and its resting sporangia have walls that appear to contain chitin. Cryptomycota, including  Rozella , lack a cell wall when absorbing food but like some other fungi, they may have lost their “dinner jacket” through convergence. Rather than evolutionary intermediates, the cryptomycota may be strange, divergent fungi that evolved from an ancestor with a nearly complete suite of classical fungal‐specific characters
Shadow enhancers: Frequently asked questions about distributed  cis ‐regulatory information and enhancer redundancy

This paper, in the form of a frequently asked questions page (FAQ), addresses outstanding questions about “shadow enhancers”, quasi‐redundant  cis ‐regulatory elements, and their proposed roles in transcriptional control. Questions include: What exactly are shadow enhancers? How many genes have shadow/redundant/distributed enhancers? How redundant are these elements? What is the function of distributed enhancers? How modular are enhancers? Is it useful to study a single enhancer in isolation? In addition, a revised definition of “shadow enhancers” is proposed, and possible mechanisms of shadow enhancer function and evolution are discussed.    The term “shadow enhancer” was coined rather recently and this article not only gives a revised definition of this term but also discusses possible mechanisms of shadow enhancer function and evolution
On the opportunistic nature of transcription and replication initiation in the metazoan genome

El pdf del artículo es la versión de autor.Cellular identity and its response to external or internal signalling variations are encoded in a cell's genome as regulatory information. The genomic regions that specify this type of information are highly variable and degenerated in their sequence determinants, as it is becoming increasingly evident through the application of genome-scale methods to study gene expression. Here, we speculate that the same scenario applies to the regulatory regions controlling where DNA replication starts in the metazoan genome. We propose that replication origins cannot be defined as unique genomic features, but rather that DNA synthesis initiates opportunistically from accessible DNA sites, making cells highly robust and adaptable to environmental or developmental changes. © 2012 WILEY Periodicals, Inc.Research at MG lab was funded by the Spanish Ministry of Sciences and Innovation (BFU2010-18992). J. S. M. is a recipient of a postdoctoral Juan de La Cierva (Spanish Ministry of Sciences and Innovation) contract.Peer Reviewe
Menin as a hub controlling mixed lineage leukemia

Mixed lineage leukemia (MLL) fusion protein (FP)‐induced acute leukemia is highly aggressive and often refractory to therapy. Recent progress in the field has unraveled novel mechanisms and targets to combat this disease. Menin, a nuclear protein, interacts with wild‐type (WT) MLL, MLL‐FPs, and other partners such as the chromatin‐associated protein LEDGF and the transcription factor C‐Myb to promote leukemogenesis. The newly solved co‐crystal structure illustrating the menin–MLL interaction, coupled with the role of menin in recruiting both WT MLL and MLL‐FPs to target genes, highlights menin as a scaffold protein and a central hub controlling this type of leukemia. The menin/WT MLL/MLL‐FP hub may also cooperate with several signaling pathways, including Wnt, GSK3, and bromodomain‐containing Brd4‐related pathways to sustain MLL‐FP‐induced leukemogenesis, revealing new therapeutic targets to improve the treatment of MLL‐FP leukemias.    In MLL fusion protein‐induced leukemias, menin is a central hub due to its role in recruiting WT MLL and MLL‐FPs to target genes. Menin also links C‐Myb/LEDGF to the MLL N‐terminus, underscoring menin's central role. Targeting menin may be especially effective due to its hub role in MLL fusion leukemias
Modeling and simulation of biological systems from image data

This essay provides an introduction to the terminology, concepts, methods, and challenges of image- based modeling in biology. Image-based modeling and simulation aims at using systematic, quantitative image data to build predictive models of biological systems that can be simulated with a computer. This allows one to disentangle molecular mechanisms from effects of shape and geometry. Questions like "what is the functional role of shape" or "how are biological shapes generated and regulated" can be addressed in the framework of image-based systems biology. The combination of image quantification, model building, and computer simulation is illustrated here using the example of diffusion in the endoplasmic reticulum
Underground allies - how and why do mycelial networks help plants defend themselves? What are the fitness, regulatory, and practical implications of defence-related signaling between plants via common mycelial networks?

Most land plants associate with mycorrhizal fungi that can connect roots of neighboring plants in common mycelial networks (CMNs). Recent evidence shows that CMNs transfer warning signals of pathogen and aphid attack between plants. However, we do not know how defence‐related signaling via CMNs operates or how ubiquitous it is. Nor do we know what the ecological relevance and fitness consequences are, particularly from the perspective of the mycorrhizal fungus. Here, we focus on the potential fitness benefits for mycorrhizal fungi and outline hypothetical scenarios in which signal transfer via CMNs is modulated in order to acquire the most benefit for the fungus (i.e. acquisition of carbon) for minimal cost. We speculate that the signal may be quantitative and may elicit plant defence responses on different levels depending on the distance the signal is transferred. Finally, we discuss the possibility of practical applications of this phenomenon for crop protection
Carbohydrate metabolism during vertebrate appendage regeneration: What is its role? How is it regulated? A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis

We recently examined gene expression during Xenopus tadpole tail appendage regeneration and found that carbohydrate regulatory genes were dramatically altered during the regeneration process. In this essay, we speculate that these changes in gene expression play an essential role during regeneration by stimulating the anabolic pathways required for the reconstruction of a new appendage. We hypothesize that during regeneration, cells use leptin, slc2a3, proinsulin, g6pd, hif1α expression, receptor tyrosine kinase (RTK) signaling, and the production of reactive oxygen species (ROS) to promote glucose entry into glycolysis and the pentose phosphate pathway (PPP), thus stimulating macromolecular biosynthesis. We suggest that this metabolic shift is integral to the appendage regeneration program and that the Xenopus model is a powerful experimental system to further explore this phenomenon