pinecone/core-2020-05-10-deduplication huggingface dataset:
Pyrethroid insecticide exposure and cognitive developmental disabilities in children: The PELAGIE mother–child cohort

International audiencePyrethroid insecticides are widely used in agriculture and in homes. Despite the neurotoxicity of these insecticides at high doses, few studies have examined whether lower-level exposures could adversely affect children's neurodevelopment. The PELAGIE cohort included 3421 pregnant women from Brittany, France between 2002 and 2006. When their children reached their sixth birthday, 428 mothers from the cohort were randomly selected, successfully contacted and found eligible. A total of 287 (67%) mothers agreed to participate with their children in the neuropsychological follow-up. Two cognitive domains were assessed by the Wechsler Intelligence Scale for Children: verbal comprehension and working memory. Five pyrethroid and two organophosphate insecticide metabolites were measured in maternal and child first-void urine samples collected between 6 and 19 gestational weeks and at 6 years of age, respectively. Linear regression models were used to estimate associations between cognitive scores and urinary pyrethroid metabolite concentrations, adjusting for organophosphate metabolite concentrations and potential confounders. Maternal prenatal pyrethroid metabolite concentrations were not consistently associated with any children's cognitive scores. By contrast, childhood 3-PBA and cis-DBCA concentrations were both negatively associated with verbal comprehension scores (P-trend = 0.04 and P-trend &lt; 0.01, respectively) and with working memory scores (P-trend = 0.05 and P-trend &lt; 0.01, respectively). No associations were observed for the three other childhood pyrethroid metabolite concentrations (4-F-3-PBA, cis-DCCA, and trans-DCCA). Low-level childhood exposures to deltamethrin (as cis-DBCA is its principal and selective metabolite), in particular, and to pyrethroid insecticides, in general (as reflected in levels of the 3-PBA metabolite) may negatively affect neurocognitive development by 6 years of age. Whatever their etiology, these cognitive deficits may be of importance educationally, because cognitive impairments in children interfere with learning and social development. Potential causes that can be prevented are of paramount public health importanc
TerraSAR-X dual-pol time-series for mapping of wetland vegetation

International audienceMapping vegetation formations at a fine scale is crucial for assessing wetland functions and for better landscape management. Identification and characterization of vegetation formations is generally conducted at a fine scale using ecological ground surveys, which are limited to small areas. While optical remotely sensed imagery is limited to cloud-free periods, SAR time-series are used more extensively for wetland mapping and characterization using the relationship between distribution of vegetation formations and flood duration. The aim of this study was to determine the optimal number and key dates of SAR images to be classified to map wetland vegetation formations at a 1:10,000 scale. A series of eight dual-polarization TerraSAR-X images (HH/VV) was acquired in 2013 during dry and wet seasons in temperate climate conditions. One polarimetric parameter was extracted first, the Shannon entropy, which varies with wetland flooding status and vegetation roughness. Classification runs of all the possible combinations of SAR images using different k (number of images) subsets were performed to determine the best combinations of the Shannon entropy images to identify wetland vegetation formations. The classification runs were performed using Support Vector Machine techniques and were then analyzed using the McNemar test to investigate significant differences in the accuracy of all classification runs based on the different image subsets. The results highlight the relevant periods (i.e. late winter, spring and beginning of summer) for mapping vegetation formations, in accordance with ecological studies. They also indicate that a relationship can be established between vegetation formations and hydrodynamic processes with a short time-series of satellite images (i.e. 5 dates). This study introduces a new approach for herbaceous wetland monitoring using SAR polarimetric imagery. This approach estimates the number and key dates required for wetland management (e.g. restoration) and biodiversity studies using remote sensing data
Sand bodies at the shelf edge in the Gulf of Lions (Western Mediterranean): Deglacial history and modern processes

International audienceThe outer continental shelf of the Gulf of Lions is covered by thick, mainly regressive, sand deposits. A combination of seismic, sedimentological and geochronological methods allows us to demonstrate that a veneer of transgressive sand bodies, few m to less than 1 m thick, reworks these deposits. They take the form of sand ridges and transverse dunes that formed at different periods. In fact, the low-gradient outer shelf of the Gulf of Lions displays a complete record of deglacial history, including not only transgressive deposits that formed during sea-level rise, but also bedforms that still evolve under episodic high-energy events that occur under more highstand conditions. Core lithology, 14C dates and regional sea-level curve suggest that the formation of the sand ridges was favoured during a period of deceleration of sea-level rise, such as during the Younger Dryas event. The dunes are part of a “mobile carpet” (here U160). The deposition of this marine sand veneer is possibly related to the interplay between different factors that trigger the turning on/off for bottom currents sand deposition/transport on the outer shelf. In fact, the sands appear to have been reworked intermittently due to high-energy conditions in shallow water depth (currents, wave regime and wind-driven circulation) as well as they form current ridges superi
Proving Determinacy of the PharOS Real-Time Operating System

International audienceExecutions in the PharOS real-time system are deterministic in the sense that the sequence of local states for every process is independent of the order in which processes are scheduled. The essential ingredient for achieving this property is that a temporal window of execution is associated with every instruction. Messages become visible to receiving processes only after the time window of the sending message has elapsed. We present a high-level model of PharOS in TLA+ and formally state and prove determinacy using the TLA+ Proof System
A weakly nonlinear mechanism for mode selection in swirling jets

International audienceGlobal linear and nonlinear bifurcation analysis is used to revisit the spiral vortex breakdown of nominally axisymmetric swirling jets. For the parameters considered herein, stability analyses single out two unstable linear modes of azimuthal wavenumber m=1 and m=2, bifurcating from the axisymmetric breakdown solution. These modes are interpreted in terms of spiral perturbations wrapped around and behind the axisymmetric bubble, rotating in time in the same direction as the swirling flow but winding in space in the opposite direction. Issues are addressed regarding the role of these modes with respect to the existence, mode selection and internal structure of vortex breakdown, as assessed from the three-dimensional direct numerical simulations of Ruith et al. (J. Fluid Mech., vol. 486, 2003, pp. 331-378). The normal form describing the leading-order nonlinear interaction between modes is computed and analysed. It admits two stable solutions corresponding to pure single and double helices. At large swirl, the axisymmetric solution bifurcates to the double helix which remains the only stable solution. At low and moderate swirl, it bifurcates first to the single helix, and subsequently to the double helix through a series of subcritical bifurcations yielding hysteresis over a finite range of Reynolds numbers, the estimated bifurcation threshold being in good agreement with that observed in the direct numerical simulations. Evidence is provided that this selection is not to be ascribed to classical mean flow corrections induced by the existence of the unstable modes, but to a non-trivial competition between harmonics. Because the frequencies of the leading modes approach a strong 2:1 resonance, an alternative normal form allowing interactions between the m=2 mode and the first harmonics of the m=1 mode is computed and analysed. It admits two stable solutions, the double helix already identified in the non-resonant case, and a single helix differing from that observed in the non-resonant case only by the presence of a slaved, phase-locked harmonic deformation. On behalf of the finite departure from the 2:1 resonance, the amplitude of the slaved harmonic is however low, and the effect of the resonance on the bifurcation structure is merely limited to a reduction of the hysteresis range
Effects on CHP plant efficiency of H 2 production through partial oxydation of natural gas over two group VIII metal catalysts

cited By (since 1996)0International audienceBlending H 2 with natural gas in spark ignition engines can increase for electric efficiency. In-situ H 2 production for spark ignition engines fuelled by natural gas has therefore been investigated recently, and reformed exhaust gas recirculation (RGR) has been identified a potentially advantageous approach: RGR uses the steam and O 2 contained in exhaust gases under lean combustion, for reforming natural gas and producing H 2, CO, and CO 2. In this paper, an alternative approach is introduced: air gas reforming circulation (AGRC). AGRC uses directly the O 2 contained in air, rendering the chemical pathway comparable to partial oxidation. Formulations based on palladium and platinum have been selected as potential catalysts. With AGRC, the concentrations of the constituents of the reformed gas are approximately 25% hydrogen, 10% carbon monoxide, 8% unconverted hydrocarbons and 55% nitrogen. Experimental results are presented for the electric efficiency and exhaust gas (CO and HC) composition of the overall system (SI engine equipped with AGRC). It is demonstrated that the electric efficiency can increase for specific ratios of air to natural gas over the catalyst. Although the electric efficiency gain with AGRC is modest at around 0.2%, AGRC can be cost effective because of its straightforward and inexpensive implementation. Misfiring and knock were both not observed in the tests reported here. Nevertheless, technical means of avoiding knock are described by adjusting the main flow of natural gas and the additional flow of AGRC. Copyright © 2012, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved
Phase transitions of a polymer threading a membrane coupled to coil-globule transitions

We theoretically study phase transitions of a polymer threading through a pore imbedded in a membrane. We focus on the coupling between a partition of the polymer segments through the membrane and a coil-globule transition of the single polymer chain. Based on the Flory model for collapse transitions of a polymer chain, we calculate the fraction of polymer segments and the expansion factor of a polymer coil on each side of the membrane. We predict a first-order phase transition of a polymer threading a membrane; polymer segments in one side are discontinuously translocated into the other side, depending on solvent conditions and molecular weight of the polymer. We also discuss the equilibrium conformation of the polymer chain on each side of the membrane
IGBT Scaling Principle Toward CMOS Compatible Wafer Processes

A scaling principle for trench gate IGBT is proposed. CMOS technology on large diameter wafer enables to produce various digital circuits with higher performance and lower cost. The transistor cell structure becomes laterally smaller and smaller and vertically shallower and shallower. In contrast, latest IGBTs have rather deeper trench structure to obtain lower on-state voltage drop and turn-off loss. In the aspect of the process uniformity and wafer warpage, manufacturing such structure in the CMOS factory is difficult. In this paper, we show the scaling principle toward shallower structure and better performance. The principle is theoretically explained by our previously proposed “Structure Oriented” analytical model. The principle represents a possibility of technology direction and roadmap for future IGBT for improving the device performance consistent with lower cost and high volume productivity with CMOS compatible large diameter wafer technologies
Mutations in SNX14 cause a distinctive autosomal-recessive cerebellar ataxia and intellectual disability syndrome

Intellectual disability and cerebellar atrophy occur together in a large number of genetic conditions and are frequently associated with microcephaly and/or epilepsy. Here we report the identification of causal mutations in Sorting Nexin 14 (SNX14) found in seven affected individuals from three unrelated consanguineous families who presented with recessively inherited moderate-severe intellectual disability, cerebellar ataxia, early-onset cerebellar atrophy, sensorineural hearing loss, and the distinctive association of progressively coarsening facial features, relative macrocephaly, and the absence of seizures. We used homozygosity mapping and whole-exome sequencing to identify a homozygous nonsense mutation and an in-frame multiexon deletion in two families. A homozygous splice site mutation was identified by Sanger sequencing of SNX14 in a third family, selected purely by phenotypic similarity. This discovery confirms that these characteristic features represent a distinct and recognizable syndrome. SNX14 encodes a cellular protein containing Phox (PX) and regulator of G protein signaling (RGS) domains. Weighted gene coexpression network analysis predicts that SNX14 is highly coexpressed with genes involved in cellular protein metabolism and vesicle-mediated transport. All three mutations either directly affected the PX domain or diminished SNX14 levels, implicating a loss of normal cellular function. This manifested as increased cytoplasmic vacuolation as observed in cultured fibroblasts. Our findings indicate an essential role for SNX14 in neural development and function, particularly in development and maturation of the cerebellum
A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia.

Lactate has been shown to offer neuroprotection in several pathologic conditions. This beneficial effect has been attributed to its use as an alternative energy substrate. However, recent description of the expression of the HCA1 receptor for lactate in the central nervous system calls for reassessment of the mechanism by which lactate exerts its neuroprotective effects. Here, we show that HCA1 receptor expression is enhanced 24 hours after reperfusion in an middle cerebral artery occlusion stroke model, in the ischemic cortex. Interestingly, intravenous injection of L-lactate at reperfusion led to further enhancement of HCA1 receptor expression in the cortex and striatum. Using an in vitro oxygen-glucose deprivation model, we show that the HCA1 receptor agonist 3,5-dihydroxybenzoic acid reduces cell death. We also observed that D-lactate, a reputedly non-metabolizable substrate but partial HCA1 receptor agonist, also provided neuroprotection in both in vitro and in vivo ischemia models. Quite unexpectedly, we show D-lactate to be partly extracted and oxidized by the rodent brain. Finally, pyruvate offered neuroprotection in vitro whereas acetate was ineffective. Our data suggest that L- and D-lactate offer neuroprotection in ischemia most likely by acting as both an HCA1 receptor agonist for non-astrocytic (most likely neuronal) cells as well as an energy substrate
The price of complexity in financial networks

Financial institutions form multilayer networks by engaging in contracts with each other and by holding exposures to common assets. As a result, the default probability of one institution depends on the default probability of all of the other institutions in the network. Here, we show how small errors on the knowledge of the network of contracts can lead to large errors in the probability of systemic defaults. From the point of view of financial regulators, our findings show that the complexity of financial networks may decrease the ability to mitigate systemic risk, and thus it may increase the social cost of financial crises
Understanding causes and effects of non-uniform light distributions on multi-junction\ud
solar cells: Procedures for estimating efficiency losses

This paper presents the mechanisms of efficiency losses that have to do with the non-uniformity of the irradiance over the multi-junction solar cells and different measurement techniques used to investigate them. To show the capabilities of the presented techniques, three different concentrators (that consist of an acrylic Fresnel lens, different SOEs and a lattice matched multi-junction cell) are evaluated. By employing these techniques is possible to answer some critical questions when designing concentrators as for example which degree of non-uniformity the cell can withstand, how critical the influence of series resistance is, or what kind of non-uniformity (spatial or spectral) causes more losses
Circularly polarised broadband planar lightweight reflectarray with eligible pattern for satellite communications in Ku-Band

This study presents a lightweight planar patch-array reflectarray at Ku-band for satellite communications. The reflectarray is composed of two separate planar structures: the radiating interface formed by a planar multi-layered broadband patch array, and a phase shifting device formed by 3 dB/90° couplers. The radiating element is a multi-layered patch structure, designed to provide circular polarisation (CP). Each array cell phase is controlled by open-ended shifting lines of variable length connected to the 3 dB/90° couplers. The use of this kind of couplers maintains the same CP received/transmitted: the design imposes that if a right-hand CP (RHCP) [or left-hand CP (LHCP)] is received coming from the feeder, the same RHCP (or LHCP) configuration is re-radiated by the reflectarray. Additionally, the feeding horn can be moved in the x or y axes, so that the feeder angular position let re-define the radiation pattern and its pointing direction. Finally, measurements of a lightweight portable planar reflectarray prototype are provided and very good agreement is observed when compared with theoretical result
The effect of acute simvastatin administration on the severity of arrhythmias resulting from ischaemia and reperfusion in the canine: Is there a role for nitric oxide?

The present study has examined the effects and the possible mechanisms of a single dose of simvastatin on the severity of arrhythmias resulting from a 25min  occlusion and reperfusion of the left anterior descending coronary artery in anaesthetized (chloralose and urethane) dogs. The control animals (n=16) were given the solvent of simvastatin by slow (over 5min) intracoronary (ic.) injection just prior to the occlusion. Twenty-six dogs were treated with simvastatin (0.1mg/kg) by the same route, both in the absence (n=15) and in the presence (n=11) of l-NAME. This latter was administered (5mg/kg, ic.) either alone (n=12) or 10min before the simvastatin treatment. The severity of ischaemia (epicardial ST-segment, inhomogeneity) and ventricular arrhythmias (ventricular premature beats [VPBs], ventricular tachycardia [VT] and fibrillation [VF]), plasma nitrite/nitrate levels, myocardial superoxide production and eNOS activity were assessed. Compared with controls simvastatin significantly reduced the number of VPBs (289+/-34vs. 94+/-25) and the episodes of VT (5.6+/-1.3vs. 0.3+/-0.2), the incidence of VT (88% vs. 20%) and VF (56% vs. 0%) during occlusion and increased survival (0% vs. 33%) on reperfusion. There were also less marked ischaemic changes in the simvastatin-treated dogs than in the controls. Simvastatin preserved eNOS activity and nitric oxide (NO) bioavailability during occlusion and attenuated superoxide production following reperfusion. All these effects of simvastatin (except for the protection against  VF) were reversed by l-NAME. We conclude that simvastatin given just prior to ischaemia/reperfusion reduces the severity of arrhythmias. This effect involves both NO-dependent and NO-independent mechanisms
Peptide synthesis by recombinant Fasciola hepatica cathepsin L1

Synthesis of the tripeptide Z-Phe-Arg-SerNH2 has been accomplished by a recombinant cysteine protease, cathepsin L1 from liver fluke (Fasciola hepatica), using Z-Phe-Arg-OMe as acyl acceptor and SerNH2 as nucleophile in 0.1 M ammonium acetate pH 9.0–12.5% v/v acetonitrile at 37 °C. LC–MS detection indicated tripeptide formation after 10 min, continuing up to 5.5 h. The ester Z-Phe-Arg-OMe was detected throughout the experiment but the hydrolysis product Z-Phe-Arg-OH appeared early and in quite large amounts. We believe that this is the first application of a parasite protease in enzymatic peptide synthesis
EBSL: supporting deleted node label reuse in XML

Recently, there has been much research into the specification of dynamic labeling schemes supporting XML updates. The primary design goal of any dynamic labeling scheme is to limit the growth rate in node label size, and consequently increase query performance and reduce update costs. The ability to reuse deleted node labels is a key property in achieving this goal. In this paper, we review the existing dynamic labeling schemes that provide this functionality and identify their shortcomings. We present our own dynamic labeling scheme that guarantees every delete node label can be reused. Further, we provide a deleted node label reuse strategy that best suits the nature of node insertions and deletions in an XML tree
Exeter at CLEF 2003: Experiments with machine translation for monolingual, bilingual and multilingual retrieval

The University of Exeter group participated in the monolingual, bilingual and multilingual-4 retrieval tasks this year. The main focus of our investigation this year was the small multilingual task comprising four languages, French, German, Spanish and English. We adopted a document translation strategy and tested four merging techniques to combine results from the separate document collections, as well as a merged collection strategy. For both the monolingual and bilingual tasks we explored the use of a parallel collection for query expansion and term weighting, and also experimented with extending synonym information to conflate British and American English word spellings
Electro-optical properties of an orthoconic liquid crystal mixture (W-182) and its molecular dynamics

We observed that the perfect dark state problem could be solved by using orthoconic antiferroelectric liquid crystal (OAFLC) instead of normal AFLC by comparing the properties of isocontrast and dispersion chromaticity of W-182 OAFLC and normal AFLC CS-4001. We electro-optically observed that several subphases such as SmCγ*, SmC*β, SmC*α and antiferroelectric SmI*A phases exist in W-182 OAFLC. We dielectrically observed in 4 μm thin cell that during heating, several new phases appeared. In the high temperature antiferroelectric region, a higher order than SmC* phase could be detected dielectrically, in the temperature range of 91–98 °C, behaving similar to SmCγ* and also, another phase below SmC* region could be dielectrically detected in the temperature range of 103–1100 °C, behaving similar to SmCα*, and an antiferroelectric, similar to SmIA* phase, was observed in the lower temperature region of the antiferroelectric phase; those are definitely arising due to surface force and interfacial charges interactions. We observed both PH and PL relaxation modes in both cells, although they differed in their strength and relaxation frequency. We studied extensively our observations of PH and PL modes in the antiferroelectric region, a Goldstone mode in the ferroelectric region and a soft mode in the ferroelectric region and SmA* phases