pinecone/core-2020-05-10-deduplication huggingface dataset:
Relationship Between Impaired Microvascular Function in the Non-Infarct-Related Area and Left Ventricular Remodeling in Patients With Myocardial Infarction

Background. Myocardial flow reserve (MFR) in the non-infarct-related area (NIRA)
	has been reported to be impaired after the onset of myocardial infarction (MI). The aim
	of this study was to determine whether microvascular dysfunction in the NIRA is related
	to left-ventricular remodeling after MI.
	Methods. We prospectively studied 17 patients who suffered their first single-vessel MI,
	and who underwent successful revascularization. The MFR in the NIRA was assessed
	quantitatively using ^13N-ammonia positron emission tomography within 2 weeks after
	the onset. Peak creatinine kinase and the defect score on ^<99m>Tc-tetrofosmin myocardial
	perfusion imaging were used as an index of the severity of MI. The left-ventricular
	end-diastolic volume index (LVEDVI) was calculated using left ventriculography at 1
	month and 6 months after the onset.
	Results. Patients with severely impaired MFR (< 2.09) had higher peak creatinine
	kinase values (6,000 ± 5,485 IU/L vs. 2,250 ± 1,950 IU/L, p = 0.0081), defect scores
	(16.3 ± 5.9 vs. 7.9 ± 6.5, p = 0.0404), and LVEDVI at 1 month (125.6 ± 34.4 mL/m^2 vs.
	82.8 ± 17.7 mL/m^2, p = 0.0036) than those with mildly impaired MFR (≥ 2.09).
	Moreover, the differences of LVEDVI between the 2 groups persisted over 6 months
	(133.3 ± 43.6 mL/m^2 vs. 89.5 ± 17.3 mL/m^2, p = 0.0078). The MFR in the NIRA
	correlated inversely with the LVEDVI at 1 month and 6 months (r = -0.590, p = 0.0127
	and r = -0.729, p = 0.0031, respectively).
	Conclusions. These data indicate that microvascular impairment in the NIRA might
	have contributed to left-ventricular remodeling after MI
Checking unimodality using isotonic regression: an application to breast cancer mortality rates

In some diseases it is well-known that a unimodal mortality pattern exists. A clear example
in developed countries is breast cancer, where mortality increased sharply until the
nineties and then decreased. This clear unimodal pattern is not necessarily applicable to all
regions within a country. In this paper, we develop statistical tools to check if the unimodality
pattern persists within regions using order restricted inference. Break points as well as
con dence intervals are also provided. In addition, a new test for checking monotonicity
against unimodality is derived allowing to discriminate between a simple increasing pattern
and an up-then-down response pattern. A comparison with the widely used joinpoint regression
technique under unimodality is provided. We show that the joinpoint technique could
fail when the underlying function is not piecewise linear. Results will be illustrated using
age-speci c breast cancer mortality data from Spain in the period 1975-2005.Ministerio de Ciencia e Innovación grant (MTM2012-37129)Spanish Ministry of Science and Innovation project MTM 2011-22664Ministerio de Ciencia e Innovación and FEDER grant MTM2014-51992-RHealth Department of Navarre Government (Project 113, Res. 2186/2014
Recognizing and engineering digital-like logic gates and switches in gene regulatory networks

A central aim of synthetic biology is to build organisms that can perform useful activities in response to specified conditions. The digital computing paradigm which has proved so successful in electrical engineering is being mapped to synthetic biological systems to allow them to make such decisions. However, stochastic molecular processes have graded input-output functions, thus, bioengineers must select those with desirable characteristics and refine their transfer functions to build logic gates with digital-like switching behaviour. Recent efforts in genome mining and the development of programmable RNA-based switches, especially CRISPRi, have greatly increased the number of parts available to synthetic biologists. Improvements to the digital characteristics of these parts are required to enable robust predictable design of deeply layered logic circuits
Strategies for teaching professional ethics to IT engineering degree students and evaluating the result

Abstract\ud
\ud
This paper presents an experience in developing professional ethics by an approach that integrates knowledge, teaching methodologies and assessment coherently. It has been implemented for students in both the Software Engineering and Computer Engineering degree programs of the Technical University of Madrid, in which professional ethics is studied as a part of a required course. Our contribution of this paper is a model for formative assessment that clarifies the learning goals, enhances the results, simplifies the scoring and can be replicated in other contexts. A quasi-experimental study that involves many of the students of the required course has been developed. To test the effectiveness of the teaching process, the analysis of ethical dilemmas and the use of deontological codes have been integrated, and a scoring rubric has been designed. Currently, this model is also being used to develop skills related to social responsibility and sustainability for undergraduate and postgraduate students of diverse academic context
Nitrogen-carbon graphite-like semiconductor synthesized from uric acid

A new carbon-nitrogen organic semiconductor has been synthesized by pyrolysis of uric acid. This layered carbon-nitrogen material contains imidazole-, pyridine (naphthyridine)- and graphitic-like nitrogen, as evinced by infrared and X-ray photoelectron spectroscopies. Quantum chemistry calculations support that it would consist of a 2D polymeric material held together by hydrogen bonds. Layers are stacked with an interplanar distance between 3.30 and 3.36 Å, as in graphite and coke. Terahertz spectroscopy shows a behavior similar to that of amorphous carbons, such as coke, with non-interacting layers. This material features substantial differences from polymeric carbon nitride, with some characteristics closer to those of nitrogen-doped graphene, in spite of its higher nitrogen content. The direct optical band gap, dependent on the polycondensation temperature, ranges from 2.10 to 2.32 eV. Although in general the degree of crystallinity is low, the material synthesized at 600 °C is composed of globular hollow particles, in which spots with a certain degree of crystallinity can be found.Junta de Castilla y León Grant VA089U1
Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup

Cationic peptides proved fundamental importance as pharmaceutical agents and/or drug carrier moieties functioning in cellular processes. The comparison of the in vitro activity of these peptides is an experimental challenge and a combination of different methods, such as cytotoxicity, internalisation rate, haemolytic and antibacterial effect, is necessary. At the same time, several issues need to be addressed as the assay conditions have a great influence on the measured biological effects and the experimental setup needs to be optimised. Therefore, critical comparison of results from different assays using representative examples of cell penetrating and antimicrobial peptides was performed and optimal test conditions were suggested. Our main goal was to identify carrier peptides for drug delivery systems of antimicrobial drug candidates. Based on the results of internalisation, haemolytic, cytotoxic and antibacterial activity assays, a classification of cationic peptides is advocated. We found eight promising carrier peptides with good penetration ability of which Penetratin, Tat, Buforin and Dhvar4 peptides showed low adverse haemolytic effect. Penetratin, Transportan, Dhvar4 and the hybrid CM15 peptide had the most potent antibacterial activity on Streptococcus pneumoniae (MIC lower than 1.2 μM) and Transportan was effective against Mycobacterium tuberculosis as well. The most selective peptide was the Penetratin, where the effective antimicrobial concentration on pneumococcus was more than 250 times lower than the HC50 value. Therefore, these peptides and their analogues will be further investigated as drug delivery systems for antimicrobial agents
Dialogical self: author and narrator of career life themes

This conceptual paper introduces the Theory of Dialogical Self to the career development literature. The life themes component of the Theory of Career Construction is the focus of application for dialogical self. It is proposed that the notion of dialogical self may contribute to understanding how individuals construct the career-related life themes. Dialogical self is thus presented as a promising theoretical construct to augment the explanatory capacity of the Theory of Career Construction and the constructivist, narrative approach to career theory in general. Implications for career counselling are presented
Low complexity video compression using moving edge detection based on DCT coefficients

In this paper, we propose a new low complexity video compression method based on detecting blocks containing moving edges us- ing only DCT coe±cients. The detection, whilst being very e±cient, also allows e±cient motion estimation by constraining the search process to moving macro-blocks only. The encoders PSNR is degraded by 2dB com- pared to H.264/AVC inter for such scenarios, whilst requiring only 5% of the execution time. The computational complexity of our approach is comparable to that of the DISCOVER codec which is the state of the art low complexity distributed video coding. The proposed method ¯nds blocks with moving edge blocks and processes only selected blocks. The approach is particularly suited to surveillance type scenarios with a static camera
An agent-based approach to immune modelling

This study focuses on trying to understand why the range\ud
of experience with respect to HIV infection is so diverse, especially as regards to the latency period. The challenge is to determine what assumptions can be made about the nature of the experience of antigenic invasion and diversity that can be modelled, tested and argued plausibly.\ud
To investigate this, an agent-based approach is used to extract high-level behaviour which cannot be described analytically from the set of interaction rules at the cellular level. A prototype model encompasses local variation in baseline properties contributing to the individual disease experience and is included in a network which mimics the chain of lymphatic nodes. Dealing with massively multi-agent systems requires major computational efforts. However, parallelisation methods are a natural\ud
consequence and advantage of the multi-agent approach. These are implemented using the MPI library
Density measurements using the Background Oriented13; Schlieren technique

This paper describes the implementation of a13; novel technique called Background Oriented Schlieren that13; can produce quantitative visualization of density in a flow.13; This technique uses only a digital still camera, a structured13; background, and inverse tomographic algorithms which13; can extract two-dimensional slices from a three-dimensional13; flow. This has been applied to obtain the density13; field for an axisymmetric supersonic flow over a conecylinder13; model. Comparisons with cone tables show13; excellent agreement
Model based optimization criteria for the generation of deep compressive residual stress fields in high elastic limit metallic alloys by ns-laser shock processing

Laser Shock Processing (LSP) is based on the application of a high intensity pulsed Laser beam (IN1 GW/cm2; τb50 ns) on a metallic target forcing a sudden vaporization of its surface into a high temperature and density plasma that immediately develops inducing a shock wave propagating into the material. The main acknowledged advantages of LSP consist on its capability of inducing a relatively deep compression residual stresses field into metallic alloy pieces allowing an improved mechanical behavior, explicitly, the life improvement of the treated specimens against wear, crack growth and stress corrosion cracking. Due to these specific advantages, Laser Shock Processing is considered as a competitive alternative technology to classical treatments for improving fatigue, corrosion cracking and wear resistance of metallic materials, and is being developed as a practical process amenable to production technology. In this paper, a model based systematization of process optimization criteria and a practical assessment on the real possibilities of the technique is presented along with practical results at laboratory scale on the application of LSP to characteristic high elastic limit metallic alloys, showing the induced residual stresses fields and the corresponding results on mechanical properties improvement induced by the treatment. The homogeneity of the residual stress fields distribution following the laser treatment spatial density will be specially analyzed
He production and induced swelling in KOYO-F

From preliminary results[1] of neutron fluxes and energy spectra obtained for the vacuum vessel of the Fast Ignition Fusion Reactor KOYO-F, the distribution of Primary Knock-on Atoms (PKA), necessary to quantify defect production, has been calculated. In the presence of He these defects could induce swelling through nucleation of voids and bubbles. Kinetic Monte Carlo models are being developed to predict the evolution of these defects in different metals. As a first study we have focused on He in Ni, since there are systematic experimental results available
Mineralogy and geochemistry of the Masa Valverde blind massive sulphide deposit, Iberian Pyrite Belt (Spain)

Masa Valverde is a blind, volcanic-hosted massive sulphide deposit recently discovered in the Spanish sector of the\ud
Iberian Pyrite Belt (IPB). The deposit is more than 1 km long and is located at depths between 400 and 850 m, in direct\ud
spatial association with a residual gravimetric anomaly. The ore body is concealed beneath Culm sedimentary rocks which\ud
cover the westem extension of a Hercynian age anticline, a few kilometers west of an area where older massive sulphide\ud
workings existed. The Masa Valverde deposit consists of two main ore bodies composed dominantly of massive and banded\ud
pyrite which are hosted by a volcano-sedimentary sequence made up of felsic tuffs interlayered with shale, siliceous exhalite\ud
and radiolarian chert. The abundance of sedimentary host rocks to the deposit is a feature shared by other large massive\ud
sulphide deposits in the eastem sector of the IPB and is interpreted as significant with respect to the origin of the deposit (a\ud
break in volcanic activity). The thickness of the upper massive sulphide orebody varies between a few meters and 70 m, and\ud
it consists of lenses and blankets of massive sulphides with interbedded tuff and shale and occasionally stockwork zones.\ud
The lower orebody is smaller and thinner than the upper one, but this may be due to incomplete drilling. Two types of\ud
stockwork occur beneath the massive sulphide bodies, the more common type consists of irregular and anastomosing\ud
sulphide veinlets and irregular blebs formed by replacement. Stockwork with cross-cutting, generally straight-sided, sulphide\ud
veins is, by contrast, suggestive of formation by hydraulic fracturing. The mineralogy and alteration processes of the ore and\ud
host rocks at Masa Valverde are analogous to those of other IPB massive sulphides
Dissociative photoionization of the NO molecule studied by photoelectron-photon coincidence technique

Low-energy photoelectron–vacuum ultraviolet (VUV) photon coincidences have been measured using synchrotron radiation excitation in the inner-valence region of the nitric oxide molecule. The capabilities of the coincidence set-up were demonstrated by detecting the 2s−1 → 2p−1 radiative transitions in coincidence with the 2s photoelectron emission in Ne. In NO, the observed coincidence events are attributed to dissociative photoionization with excitation, whereby photoelectron emission is followed by fragmentation of excited NO+ ions into O+ + N* or N+ + O* and VUV emission from an excited neutral fragment. The highest coincidence rate occurs with the opening of ionization channels which are due to correlation satellites of the 3σ photoionization. The decay time of VUV photon emission was also measured, implying that specific excited states of N atoms contribute significantly to observed VUV emission
Quantitative study of hydration of C3S and C2S by thermal analysis. Evolution and composition of C-S-H gels formed

This research is part of a European project (namely, CODICE project), main objective of which is modelling, at a multi-scale, the evolution of the mechanical performance of non-degraded and degraded cementitious matrices. For that, a series of experiments were planned with pure synthetic tri-calcium silicate (C3S) and bi-calcium silicate (C2S) (main components of the Portland cement clinker) to obtain different calcium–silicate–hydrate (C–S–H) gel structures during their hydration. The characterization of those C–S–H gels and matrices will provide experimental parameters for the validation of the multi-scale modelling scheme proposed. In this article, a quantitative method, based on thermal analyses, has been used for the determination of the chemical composition of the C–S–H gel together with the degree of hydration and quantitative evolution of all the components of the pastes. Besides, the microstructure and type of silicate tetrahedron and mean chain length (MCL) were studied by scanning electron microscopy (SEM) and 29Si magic-angle-spinning (MAS) NMR, respectively. The main results showed that the chemical compositions for the C–S–H gels have a CaO/SiO2 M ratio almost constant of 1.7 for both C3S and C2S compounds. Small differences were found in the gel water content: the H2O/SiO2 M ratio ranged from 2.9 ± 0.2 to 2.6 ± 0.2 for the C3S (decrease) and from 2.4 ± 0.2 to 3.2 ± 0.2 for the C2S (increase). The MCL values of the C–S–H gels, determined from 29Si MAS NMR, were 3.5 and 4 silicate tetrahedron, for the hydrated C3S and C2S, respectively, remaining almost constant at all hydration periods
Flying vs. climbing: Factors controlling arboreal seed removal in oak-beech forests

Nuts are heavy and nutritious seeds that need animals to be successfully dispersed. Most studies address nut removal by a single animal species once seeds fall onto the ground. However, nuts are also accessible before the seed drop and usually to a wide guild of seed foragers. This study examines the factorscontrollingarborealseedremoval in oak–beechforests within the whole guild of nut foragers. We found that seed-dispersing rodents (Apodemus sylvaticus) were the main acorn removers in the oaks (up to 3.75 m height), with a rapid seed encounter and a high removal rate. However, rodents did not climb the beech trees, probably due to their smoother bark in comparison to oak bark and/or the lower nutritional value of beechnuts with regard to acorns. Jays (Garrulus glandarius) were more abundant in oak stands (both dense and scattered) and clearly preferred acorns to beechnuts whereas nuthatches (Sitta europaea) were more abundant in beech stands and preferred beechnuts to acorns. Non-storing birds such as great tits (Parus major) also removed acorns and beechnuts, especially in the stands where oaks are dominant. Jays and rodents preferred sound seeds over insect-infested seeds but such a preference was not found for nuthatches. This study highlights that pure beech stands showed a reduced guild of arboreal nut foragers in comparison to oak stands. This different guild could probably affect the spatial patterns of seed dispersal, with a proportionally higher number of long dispersal events for acorns (mostly jay-dispersed) than for beechnuts (mostly nuthatch-dispersed). Long-distance dispersal of beechnuts (by jays) is determined by the presence of other preferred species (oaks) and their frequency of non-mast years. Seed location in different habitats strongly determines the contribution of different arboreal removers (including climbing rodents) and their removal speed, leading to a differential seed fate that will eventually affect tree regeneration. As nuthatches are sedentary birds, it is important to maintain old and dead trees where they can breed (crevices), forage (arthropods) and store seeds in order to favor beechnut dispersal and gene flow. By maintaining or favoring oak trees within beech stands we will ensure a wider guild of arboreal nut dispersers
Culture and diversity in knowledge creation

Is the paradise of effortless communication the ideal environment for knowledge creation?  Or, can the development of local culture in regions raise knowledge productivity compared to a single region with a unitary culture?  In other words, can a real technological increase in the cost of collaboration and the cost of public knowledge flow between regions, resulting in cultural differentiation between regions, increase welfare?  In our framework, a culture is a set of ideas held exclusively by residents of a location. In general in our model, the equilibrium path generates separate cultures in different regions. When we compare this to the situation where all workers are resident in one region, R & D workers become too homogeneous and there is only one culture. As a result, equilibrium productivity in the creation of new knowledge is lower relative to the situation when there are multiple cultures and workers are more diverse.
Shock adhesion test for composite bonded assembly using a high pulsed power generator

In a context of the rising use of composite assemblies in aeronautic or defense fields, the assessment of their strength is a key issue. The method developed in this study attempts to provide solutions. A shock adhesion test based on short compressive loads, obtained by a high pulsed power generator, is proposed as a proof test to ensure the quality of composite bonded assemblies. A calibrated load induces a local tensile stress able to damage the bond interface. The high pulsed power source is the GEnerateur de Pression Isentropique device (Isentropic Pressure Generator), used to generate the required stresses, with a 450 ns pulse duration to test assemblies above the mm thickness range. The understanding of the mechanisms of wave propagation and tensile stress generation within these multilayer assemblies are scientific challenges. The ability of the technique to induce a tensile stress able to disbond the laminates and the assemblies is demonstrated. This paper details the response of
carbon epoxy laminates and their bonded assemblies to a shock loading near the damage threshold
Effects of the Amount of Fillers and of the Crosslink Density on the Mechanical Behavior of Carbon-Black Filled Styrene Butadiene Rubbers

Several carbon-black filled styrene-butadiene rubbers are subjected to monotonic uniaxial tension tests in order to investi-gate the effects of the amount of fillers and of the crosslink density on their mechanical properties. The Young modulus, the volume changes associated with material damage and the stretch to failure are extracted and discussed. Results compare well to the literature results when exist and quantitative analysis are proposed when possible. Results show that filled rubbers are not incompressible when submitted to uniaxial tension tests and their volume changes are strongly dependent of the amount of fillers but are unaffected by the crosslink density. The latter shows strong impact on the filled rubbers stretch to failure but more interestingly this impact is com-parable to what is encountered in unfilled rubbers. The stretch to failure is improved by the addition of fillers with an optimum for material filled around 30 phr