pinecone/core-2020-05-10-deduplication huggingface dataset:
Unbalanced sediment budgets in the catchment-alluvial fan system of the Kuitun River (northern Tian Shan, China): Implications for mass-balance estimates, denudation and sedimentation rates in orogenic systems

International audienceMass balances are often used to calculate sediment fluxes in foreland basins and denudation rates in adjacent mountain ranges on intermediate to long timescales (from a few tens of thousand to a million years). Here, we study the simple Quaternary catchment-alluvial fan system of the Kuitun River, in northern Tian Shan, to discuss some ideas about sediment storage, release, and bypass in relatively short (100 km long) sediment routing systems. This study shows that the Kuitun catchment and piedmont areas clearly present evidence of a significant and temporary storage of sediments during the Pleistocene. These sediments were then excavated and delivered farther into the foreland basin during the Holocene. The difference between the volumes of materials released from the catchment and piedmont areas (5.5 ± 1.7 km3) and the volume stored in a contemporaneous fan downstream (2.6 ± 0.6 km3) indicates that the latter did not trap the whole sediment load transported by the river. The alluvial fan was bypassed by 27 to 78% of this load toward its distal alluvial plain. If this value is well estimated, it implies a major volumetric partitioning of the deposits between the fan and the alluvial plain, with a very high sedimentation rate in the fan (1.97 ± 0.52 mm*y− 1) and a much lower one downstream (0.11 ± 0.11 mm*y− 1). However, this volumetric partitioning might only occur during periods with a very specific hydrological regime such as the Holocene deglaciation. Eventually, the peculiar sediment storage and release pattern within the Kuitun catchment and piedmont areas during the Pleistocene and Holocene complicates the calculation of mean paleodenudation rates using either sediment budgets or in situ produced cosmogenic nuclides
Effect of engineered nanoparticles on vasomotor responses in rat intrapulmonary artery.

International audiencePulmonary circulation could be one of the primary vascular targets of finest particles that can deeply penetrate into the lungs after inhalation. We investigated the effects of engineered nanoparticles on vasomotor responses of small intrapulmonary arteries using isometric tension measurements. Acute in vitro exposure to carbon nanoparticles (CNP) decreased, and in some case abolished, the vasomotor responses induced by several vasoactive agents, whereas acute exposure to titanium dioxide nanoparticles (TiO(2)NP) did not. This could be attributed to a decrease in the activity of those vasoactive agents (including PGF(2)(alpha), serotonin, endothelin-1 and acetylcholine), as suggested when they were exposed to CNP before being applied to arteries. Also, CNP decreased the contraction induced by 30 mM KCl, without decreasing its activity. After endoplasmic reticulum calcium stores depletion (by caffeine and thapsigargin), CaCl(2) addition induced a contraction, dependent on Store-Operated Calcium Channels that was not modified by acute CNP exposure. Further addition of 30 mM KCl elicited a contraction, originating from activation of Voltage-Operated Calcium Channels that was diminished by CNP. Contractile responses to PGF(2)(alpha) or KCl, and relaxation to acetylcholine were modified neither in pulmonary arteries exposed in vitro for prolonged time to CNP or TiO(2)NP, nor in those removed from rats intratracheally instilled with CNP or TiO(2)NP. In conclusion, prolonged in vitro or in vivo exposure to CNP or TiO(2)NP does not affect vasomotor responses of pulmonary arteries. However, acute exposure to CNP decreases contraction mediated by activation of Voltage-Operated, but not Store-Operated, Calcium Channels. Moreover, interaction of some vasoactive agents with CNP decreases their biological activity that might lead to misinterpretation of experimental data
Modeling tumor cell migration: from microscopic to macroscopic

Final published version; 14 pages, 7 figuresInternational audienceIt has been shown experimentally that contact interactions may influence the migration of cancer cells. Previous works have modelized this thanks to stochastic, discrete models (cellular automata) at the cell level. However, for the study of the growth of real-size tumors with several millions of cells, it is best to use a macroscopic model having the form of a partial differential equation (PDE) for the density of cells. The difficulty is to predict the effect, at the macroscopic scale, of contact interactions that take place at the microscopic scale. To address this we use a multiscale approach: starting from a very simple, yet experimentally validated, microscopic model of migration with contact interactions, we derive a macroscopic model. We show that a diffusion equation arises, as is often postulated in the field of glioma modeling, but it is nonlinear because of the interactions. We give the explicit dependence of diffusivity on the cell density and on a parameter governing cell-cell interactions. We discuss in details the conditions of validity of the approximations used in the derivation and we compare analytic results from our PDE to numerical simulations and to some in vitro experiments. We notice that the family of microscopic models we started from includes as special cases some kinetically constrained models that were introduced for the study of the physics of glasses, supercooled liquids and jamming systems
Rnd family genes are differentially regulated by 3,4-methylenedioxymethamphetamine and cocaine acute treatment in mice brain.

International audienceDrugs of abuse induce alterations in cytoskeletal and cytoskeleton associated genes in several brain areas. We have previously shown that acute MDMA regulates the mRNA level of Rnd3, a Rho GTPase involved in actin cytoskeleton regulation, in mice striatum. In this study we investigated the effects of single administration of cocaine, another psychostimulant with a slightly different mechanism of action, on the mRNA levels of the three members of the Rnd genes family (Rnd1, Rnd2 and Rnd3). Mice were treated with either MDMA (9 mg/kg) or cocaine (20 mg/jg) and brain samples (i.e. hippocampus, striatum and prefrontal cortex) were processed for quantitative real-time PCR assay 1, 2, 4 and 6 h after the injections. The expression level of Rnd2 was differentially affected depending on the drug, brain area and time point after injection. Interestingly the two drugs up-regulate Rnd3 gene expression in the three structures tested with some differences in the timing. The effects of MDMA on Rnd3 appear earlier in the hippocampus as compared to cocaine, while it is the opposite in the prefrontal cortex. However, in the dorsal striatum, the two drugs induce an early and significant up-regulation of Rnd3 expression that is longer-lasting in the case of MDMA. In the case of cocaine contrarily to what was observed with MDMA, this modulation could not be blocked with the ERK activation inhibitor SL327 suggesting that the two drugs lead to the same effect on Rnd3 by two distinct pathways
The Einstein Telescope: a third-generation gravitational wave observatory

International audienceET: a 3 rd generation GW observatory 2 10 Abstract. Advanced gravitational wave interferometers, currently under realization, will soon permit the detection of gravitational waves from astronomical sources. To open the era of precision gravitational-wave astronomy, a further substantial improvement in sensitivity is required. The future space-based Laser Interferometer Space Antenna (LISA) and the third-generation ground-based observatory Einstein Telescope (ET) promise to achieve the required sensitivity improvements in frequency ranges. The vastly improved sensitivity of the third generation of gravitational-wave observatories could permit detailed measurements of the sources ' physical parameters and could complement, in a multi-messenger approach, the observation of signals emitted by cosmological sources obtained through other kinds of telescopes. This paper describes the progresses of the ET project which is currently in its design study phase. ET: a 3 rd generation GW observatory 3 PACS numbers: 04.80.Nn Submitted to: Class. Quantum Grav. ET: a 3 rd generation GW observatory
Phonemes as images
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An experimental inquiry into shape-sound symbolism applied to the distinctive features of French

International audienceThis paper attempts to improve the understanding of shape-sound symbolism by isolating the phonological features of the pseudo-words used in the experiments and the graphic features of the figures matched with them. In a first section, it analyses the classic maluma-takete effect from both an articulatory and acoustical point of view, showing that it is determined by several phonological features operating simultaneously. In a second section, two new experiments are presented to isolate, first, vowels and consonants and, second, the consonant features of [voicing], [manner of articulation], [nasality] and [place of articulation] in relation to the graphic features of {acuity}, {continuity}, {curvature}, {regularity}, and {density}. The main result is that each phonological feature shows a different pattern of correlations with the graphic features, determined by its subtle phono-articulatory and phono-acoustic structure
Elusive anion growth in Titan’s atmosphere: low temperature kinetics of the C3N−− + HC3N reaction

International audienceIon chemistry appears to be deeply involved in the formation of heavy molecules in the upper atmosphere of Titan. These large species form the seeds of the organic aerosols responsible for the opaque haze surrounding the biggest satellite of Saturn. The chemical pathways involving individual anions remain however mostly unknown. The determination of the rates of the elementary reactions with ions and the identification of the products are essential to the progress in our understanding of Titan’s upper atmosphere. We have taken steps in that direction through the investigation of the low temperature reactivity of C3N−,−, which was tentatively identified in the spectra measured by the CAPS-ELS instrument of the Cassini spacecraft during its high altitude flybys. The reaction of this anion with HC3N, one of the most abundant trace organics in the atmosphere, has been studied over the 49–294 K temperature range in uniform supersonic flows using the CRESU technique. The proton transfer is found to be the main exit channel ( > 91%) of the CView the MathML source315N−− + HC3N reaction. It remains however indistinguishable with the non-isotopically labeled CView the MathML source314N−− reactant. The T−1/2T−1/2 temperature dependence of this proton transfer reaction and its global rate are reasonably well reproduced theoretically using an average dipole orientation model. A minor exit channel, reactive detachment ( < 9%), has also been uncovered, although the nature of the neutral products has not been determined. It is concluded that the CView the MathML source314N−− + HC3N reaction cannot contribute to the growth of molecular anions in the upper atmosphere of Titan. Due to the low branching into the neutral exit channel, it cannot contribute either to the growth of neutrals even assuming a complete mass transfer
Residence time distributions for hydrologic systems: Mechanistic foundations and steady-state analytical solutions

International audienceThis review presents the physical mechanisms generating residence time distributions (RTDs) in hydrologic systems with a focus on steady-state analytical solutions. Steady-state approximations of the RTD in hydrologic systems have seen widespread use over the last half-century because they provide a convenient, simplified modeling framework for a wide range of problems. The concept of an RTD is useful anytime that characterization of the timescales of flow and transport in hydrologic systems is important, which includes topics like water quality, water resource management, contaminant transport, and ecosystem preservation. Analytical solutions are often adopted as a model of the RTD and a broad spectrum of models from many disciplines has been applied. Although these solutions are typically reduced in dimensionality and limited in complexity, their ease of use makes them preferred tools, specifically for the interpretation of tracer data. Our review begins with the mechanistic basis for the governing equations, highlighting the physics for generating a RTD, and a catalog of analytical solutions follows. This catalog explains the geometry, boundary conditions and physical aspects of the hydrologic systems, as well as the sampling conditions, that altogether give rise to specific RTDs. The similarities between models are noted, as are the appropriate conditions for their applicability. The presentation of simple solutions is followed by a presentation of more complicated analytical models for RTDs, including serial and parallel combinations, lagged systems, and non-Fickian models. The conditions for the appropriate use of analytical solutions are discussed, and we close with some thoughts on potential applications, alternative approaches, and future directions for modeling hydrologic residence time
Late Ordovician scolecodonts from the Qusaiba-1 core hole, central Saudi Arabia, and their paleogeographical affinities

International audienceThis paper reports the discovery of Late Ordovician scolecodonts from the Qusaiba-1 core hole, central Saudi Arabia. The collection of about 100 relatively well preserved diagnostic jaws represents one of the richest jawed polychaete faunas from the Gondwanan realm and the first description of scolecodonts from the Arabian Peninsula. Scolecodonts were most diverse and abundant in the Quwarah Member and basal Sarah Formation, corresponding to the Ancyrochitina merga and Tanuchitina elongata chitinozoan zones (latest Katian to early Hirnantian). The polychaete assemblage contains up to 15 apparatus-based species and is dominated by the globally distributed genera Kettnerites, Oenonites and Atraktoprion, and a new genus of probable ramphoprionid affinity. Additionally, Skalenoprion and Kalloprion? are recorded, both for the first time from Gondwana. Characteristic of the assemblage is very low frequency of taxa with placognath-type jaws. Comparing the Qusaiba-1 assemblage with coeval faunas of Baltica and Laurentia revealed that northern Gondwana was more similar to mid-continent Laurentia than Baltica. High proportion of paulinitids, ramphoprionids and atraktoprionids, and scarcity of placognaths is typical of both northern Gondwana and Laurentia. The Baltic faunas, in contrast, had several endemic genera particularly among placognaths, whereas paulinitids and ramphoprionids were rare. This anomalous biogeographic pattern, diverging from that of most other fossil groups, cannot be fully explained without additional first-hand data from the Middle and early Late Ordovician of Gondwana and Laurentia
Compact relaxations for polynomial programming problems

Reduced RLT constraints are a special class of Reformulation- Linearization Technique (RLT) constraints. They apply to nonconvex (both continuous and mixed-integer) quadratic programming problems subject to systems of linear equality constraints. We present an extension to the general case of polynomial programming problems and discuss the derived convex relaxation. We then show how to perform rRLT constraint generation so as to reduce the number of inequality constraints in the relaxation, thereby making it more compact and faster to solve. We present some computational results validating our approach
Structure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects.

The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is a member of the ATP-binding cassette transporter superfamily that functions as an epithelial chloride channel. Gating of the CFTR ion conduction pore involves a conserved irreversible cyclic mechanism driven by ATP binding and hydrolysis at two cytosolic nucleotide-binding domains (NBDs): formation of an intramolecular NBD dimer that occludes two ATP molecules opens the pore, whereas dimer disruption after ATP hydrolysis closes it. CFTR dysfunction resulting from inherited mutations causes CF. The most common CF mutation, deletion of phenylalanine 508 (DeltaF508), impairs both protein folding and processing and channel gating. Development of DeltaF508 CFTR correctors (to increase cell surface expression) and potentiators (to enhance open probability, Po) is therefore a key focus of CF research. The practical utility of 5-nitro-2-(3-phenylpropylamino)benzoate (NPPB), one of the most efficacious potentiators of DeltaF508 CFTR identified to date, is limited by its pore-blocking side effect. NPPB-mediated stimulation of Po is unique in that it involves modulation of gating transition state stability. Although stabilization  by NPPB of the transition state for pore opening enhances both the rate of channel opening and the very slow rate of nonhydrolytic closure, because of CFTR's cyclic gating mechanism, the net effect is Po stimulation. In addition, slowing of ATP hydrolysis by NPPB delays pore closure, further enhancing Po. Here we show that NPPB stimulates gating at a site outside the pore and that these individual actions of NPPB on CFTR are fully attributable to one or the other of  its two complementary molecular parts, 3-nitrobenzoate (3NB) and 3-phenylpropylamine (3PP), both of which stimulate Po: the pore-blocking 3NB selectively stabilizes the transition state for opening, whereas the nonblocking  3PP selectively slows the ATP hydrolysis step. Understanding structure-activity relationships of NPPB might prove useful for designing potent, clinically relevant CFTR potentiators
Sustainable supply chain network design: An optimization-oriented review

International audienceSupply chain network design (SCND) models and methods have been the subject of several recent literature review surveys, but none of them explicitly includes sustainable development as a main characteristic of the problem considered. The aim of this review is to bridge this gap. The paper analyzes 87 papers in the field of supply chain network design, covering mathematical models that include economic factors as well as environmental and/or social dimensions. The review is organized along four research questions asking (i) which environmental and social objectives are included, (ii) how are they integrated into the models, (iii) which methods and tool are used and finally (iv) which industrial applications and contexts are covered in these models. The review finds that there are a number of limitations to the current research in sustainable SCND. The narrow scope of environmental and social measures in current models should go beyond limited greenhouse gas indicators to broader life-cycle approaches including new social metrics. The more effective inclusion of uncertainty and risk in models with improved multi-objective approaches is also needed. There are also significant gaps in the sectors used to test models limiting more general applicability. The paper concludes with promising new avenues of research to more effectively include sustainability into SCND models
Formal Verification of e-Auction Protocols

International audienceAuctions have a long history, having been recorded as early as 500 B.C.. With the rise of Internet, electronic auctions have been a great success and are increasingly used. Many cryptographic protocols have been proposed to address the various security requirements of these electronic transactions. We propose a formal framework to analyze and verify security properties of e-Auction protocols. We model protocols in the Applied π-Calculus and define privacy notions, which include secrecy of bids, anonymity of the participants, receipt-freeness and coercion-resistance. We also discuss fairness, non-repudiation and non-cancellation. Additionally we show on two case studies how these properties can be verified automatically using ProVerif, and discover several attacks
Dynamics of Drop Coalescence on a Surface: The Role of Initial Conditions and Surface Properties

International audienceAn investigation of the coalescence of two water drops on a surface is presented and compared with drop spreading. The associated capillary numbers are very low (< 10-5). The drops relax exponentially towards equilibrium. The typical relaxation time tc decreases with contact angle. tc is proportional to the drop size R, thus defining a characteristic velocity U* =R/tc. The corresponding U* values are smaller by many orders of magnitude than the bulk hydrodynamic velocity (U = /, with  the gas-liquid surface tension and  the viscosity). The dynamics of receding (coalescence) and spreading motion is found of the same order when coalescence or spreading is induced by a syringe. The dynamics of coalescence induced with the syringe deposition is systematically faster by an order of magnitude than condensation-induced coalescence. This disparity is explained by the coupling of the contact line motion with the oscillation of the drop observed for syringe deposition but absent for condensation-induced coalescence
First-Order Transition in the Magnetic Vortex Matter in Superconducting MgB2 Tuned by Disorder

International audienceThe field-driven transition from an ordered Bragg glass to a disordered vortex phase in singlecrystalline MgB2 is tuned by an increasing density of point defects, introduced by electron irradiation. The discontinuity observed in magnetization attests to the first-order nature of the transition. The temperature and defect density dependences of the transition field point to vortex pinning mediated by fluctuations in the quasiparticle mean free path, and reveal the mechanism of the transition in the absence of complicating factors such as layeredness or thermal fluctuations
The effect of oilseed rape occurrence on main prey abundance and breeding success of the Common Buzzard Buteo buteo

Capsule The occurrence of oilseed rape increased main prey abundance and breeding success of Common Buzzards.

Aims We tested whether the occurrence of oilseed rape influences the abundance of Common Voles, i.e. the main prey of Common Buzzards and so also nesting activity and breeding success of Common Buzzards.

Methods The study was carried out in 2005–2012 in a 38 km2 area in western Poland, where oilseed rape plantations (12–106 ha) covered 18% of the agricultural land. The number of active burrow entrances was used as an index of vole abundance in various crops, and Buzzard breeding performance, i.e. the occurrence of annual nesting attempts in individual long-term nesting sites as well as the presence and number of fledglings, was estimated by observations of their nests.

Results The index of vole abundance was highest in oilseed rape, and judging by the proportion of active burrow entrances (33–77%), the plantations of rape typically supported a larger portion of the local vole population than other crops. The acreage of oilseed rape fields around individual nesting sites of Buzzards did not affect the probability of nesting attempts in these sites. However, the probability of successful nesting and the number of fledglings per successful nest increased with the area of oilseed rape around the Buzzard nesting sites.

Conclusion The occurrence of oilseed rape may positively affect prey availability and in turn the breeding success of Buzzards. The spread of oilseed rape may therefore also be beneficial for other vole-eating raptors hunting in the agricultural landscapes