pinecone/core-2020-05-10-deduplication huggingface dataset:
First International New Intravascular Rigid-Flex Endovascular Stent Study (FINESS): Clinical and Angiographic Results After Elective and Urgent Stent Implantation fn1fn1This study was supported in part by a grant from Medinol, Ltd., Kiryat Atidim, Tel Aviv, Israel.

AbstractObjectives. The purpose of this study was to determine the feasibility, safety and efficacy of elective and urgent deployment of the new intravascular rigid-flex (NIR) stent in patients with coronary artery disease.Background. Stent implantation has been shown to be effective in the treatment of focal, new coronary stenoses and in restoring coronary flow after coronary dissection and abrupt vessel closure. However, currently available stents either lack flexibility, hindering navigation through tortuous arteries, or lack axial strength, resulting in suboptimal scaffolding of the vessel. The unique transforming multicellular design of the NIR stent appears to provide both longitudinal flexibility and radial strength.Methods. NIR stent implantation was attempted in 255 patients (341 lesions) enrolled prospectively in a multicenter international registry from December 1995 through March 1996. Nine-, 16- and 32-mm long NIR stents were manually crimped onto coronary balloons and deployed in native coronary (94%) and saphenous vein graft (6%) lesions. Seventy-four percent of patients underwent elective stenting for primary or restenotic lesions, 21% for a suboptimal angioplasty result and 5% for threatened or abrupt vessel closure. Fifty-two percent of patients presented with unstable angina, 48% had a previous myocardial infarction, and 45% had multivessel disease. Coronary lesions were frequently complex, occurring in relatively small arteries (mean [±SD] reference diameter 2.8 ± 0.6 mm). Patients were followed up for 6 months for the occurrence of major adverse cardiovascular events.Results. Stent deployment was accomplished in 98% of lesions. Mean minimal lumen diameter increased by 1.51 ± 0.51 mm (from 1.09 ± 0.43 mm before to 2.60 ± 0.50 mm after the procedure). Mean percent diameter stenosis decreased from 61 ± 13% before to 17 ± 7% after intervention. A successful interventional procedure with <50% diameter stenosis of all treatment site lesions and no major adverse cardiac events within 30 days occurred in 95% of patients. Event-free survival at 6 months was 82%. Ninety-four percent of surviving patients were either asymptomatic or had mild stable angina at 6 month follow-up.Conclusions. Despite unfavorable clinical and angiographic characteristics of the majority of patients enrolled, the acute angiographic results and early clinical outcome after NIR stent deployment were very promising. A prospective, randomized trial comparing the NIR stent with other currently available stents appears warranted
Second-order corrections to mean field evolution of weakly interacting Bosons. II

AbstractWe study the evolution of an N-body weakly interacting system of Bosons. Our work forms an extension of our previous paper Grillakis, Machedon, and Margetis (2010) [13], in which we derived a second-order correction to a mean-field evolution law for coherent states in the presence of small interaction potential. Here, we remove the assumption of smallness of the interaction potential and prove global existence of solutions to the equation for the second-order correction. This implies an improved Fock-space estimate for our approximation of the N-body state
A New Approach to Ocean Eddy Detection, Tracking, and Event Visualization –Application to the Northwest Pacific Ocean

AbstractHigh-resolution ocean general circulation models have advanced the numerical study of ocean eddies. To gain an understanding of ocean eddies from the large volume of data produced by simulations, visualizing just the distribution of eddies at each time step is insufficient; time- variations in eddy events and phenomena must also be considered. However, existing methods cannot accurately detect and track eddy events such as amalgamation and bifurcation. In this study, we propose a new approach for eddy detection, tracking, and event visualization based on an eddy classification system. The proposed method detects streams and currents in addition to eddies, and it classifies detected eddies into several categories using the additional stream and current information. By tracking how the classified eddies vary over time, it is possible to detect events such as eddy amalgamation and bifurcation as well as the interaction between eddies and ocean currents. We visualize the detected eddies and events in a time series of images (or animation), enabling us to gain an intuitive understanding of a region of interest hidden in a high-resolution data set
Viral cell-to-cell movement requires formation of cortical punctate structures containing Red clover necrotic mosaic virus movement protein

AbstractMovement protein (MP) of Red clover necrotic mosaic virus (RCNMV) forms punctate structures on the cortical endoplasmic reticulum (ER) of Nicotiana benthamiana cells, which are associated with viral RNA1 replication (Kaido et al., Virology 395, 232–242. 2009). We investigated the significance of ER-targeting by MP during virus movement from cell to cell, by analyzing the function of a series of MPs with varying length deletions at their C-terminus, either fused or not fused with green fluorescent protein (GFP). The C-terminal 70 amino acids were crucial to ER-localization of MP-GFP and cell-to-cell movement of the recombinant virus encoding it. However, C-terminal deletion did not affect MP functions, such as increasing the size exclusion limit of plasmodesmata, single-stranded RNA binding in vitro, and MP interacting in vivo. We discuss the possible role of this MP region in virus movement from cell to cell
On root categories of finite-dimensional algebras

AbstractFor any finite-dimensional algebra A over a field k of finite global dimension, we investigate the root category RA as the triangulated hull of the 2-periodic orbit category of A via the construction of B. Keller in “On triangulated orbit categories”. This is motivated by Ringel–Hall Lie algebras associated to 2-periodic triangulated categories. As an application, we study the Ringel–Hall Lie algebras for a class of finite-dimensional k-algebras of global dimension 2, which turns out to give an alternative answer to a question of GIM-Lie algebras by Slodowy in “Beyond Kac–Moody algebra, and inside”
Ds0⁎±(2317) and KD scattering from Bs0 decay

AbstractWe study the B¯s0→Ds−(KD)+ weak decay, and look at the KD invariant mass distribution, for which we use recent lattice QCD results for the KD interaction from where the Ds0⁎(2317) resonance appears as a KD bound state. Since there are not yet experimental data on this reaction, in a second step we propose an analysis method to obtain information on the Ds0⁎(2317) resonance from the future experimental KD mass distribution in this decay. For this purpose, we generate synthetic data taking a few points from our theoretical distribution, to which we add a 5% or 10% error. With this analysis method, we prove that one can obtain from these “data” the existence of a bound KD state, the KD scattering length and effective range, and most importantly, the KD probability in the wave function of the bound state obtained, which was found to be largely dominant in lattice QCD studies. This means that one can obtain information on the nature of the Ds0⁎+(2317) resonance from the implementation of this experiment, in the line of finding the structure of resonances, which is one of the main aims in hadron spectroscopy
Elevated levels of ZAC1 disrupt neurogenesis and promote rapid in vivo reprogramming

AbstractThe zinc finger transcription factor Zac1 is expressed in dividing progenitors of the nervous system with expression levels negatively controlled by genomic imprinting. To explore the consequences of elevated ZAC1 levels during neurogenesis we overexpressed it in the developing CNS. Increased levels of ZAC1 rapidly promoted upregulation of CDK inhibitors P57 and P27 followed by cell cycle exit. Surprisingly this was accompanied by stalled neuronal differentiation. Genome wide expression analysis of cortical cells overexpressing Zac1 revealed a decrease in neuronal gene expression and an increased expression of imprinted genes, factors regulating mesoderm formation as well as features of differentiated muscle. In addition, we observed a rapid induction of several genes regulating pluripotency. Taken together, our data suggests that expression levels of Zac1 need to be kept under strict control to avoid premature cell cycle exit, disrupted neurogenesis and aberrant expression of non-neuronal genes including pluripotency associated factors
Leptogenesis, Yukawa textures and weak-basis invariants

AbstractWe show that a large class of sets of leptonic texture zeros considered in the literature imply the vanishing of certain CP-odd weak-basis invariants. These invariant conditions enable one to recognize a flavour model corresponding to a set of texture zeros, when written in an arbitrary weak-basis where the zeros are not manifest. We also analyse the rôle of texture zeros in allowing for a connection between leptogenesis and low-energy leptonic masses, mixing and CP violation. For some of the textures the variables relevant for leptogenesis can be fully determined in terms of low energy parameters and heavy neutrino masses
Recognition of the ligand-type specificity of classical and non-classical MHC I proteins

AbstractFunctional characterization of proteins belonging to the MHC I superfamily involves knowing their cognate ligands, which can be peptides, lipids or none. However, the experimental identification of these ligands is not an easy task and generally requires some a priori knowledge of their chemical nature (ligand-type specificity). Here, we trained k-nearest neighbor and support vector machine classifiers that predict the ligand-type specificity MHC I proteins with great accuracy. Moreover, we applied these classifiers to human and mouse MHC I proteins of uncharacterized ligands, obtaining some results that can be instrumental to unravel the function of these proteins
Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing

AbstractFlavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in dementia. Amyloid precursor protein processing and the subsequent generation of amyloid beta (Aβ) are central to the pathogenesis of Alzheimer's disease, as soluble, oligomeric Aβ is thought to be the toxic species driving disease progression. We undertook an in vitro screen to identify flavonoids with bioactivity at βγ-mediated amyloid precursor protein processing, which lead to identification of a number of flavonoids bioactive at 100 nM. Because of known bioavailability, we investigated the catechin family further and identified epigallocatechin and (−)-epicatechin as potent (nanomolar) inhibitors of amyloidogenic processing. Supporting this finding, we have shown reduced Aβ pathology and Aβ levels following short term, a 21-day oral delivery of (−)-epicatechin in 7-month-old TASTPM mice. Further, in vitro mechanistic studies suggest this is likely because of indirect BACE1 inhibition. Taken together, our results suggest that orally delivered (−)-epicatechin may be a potential prophylactic for Alzheimer's disease
Upper bounds and algorithms for parallel knock-out numbers

AbstractWe study parallel knock-out schemes for graphs. These schemes proceed in rounds in each of which each surviving vertex simultaneously eliminates one of its surviving neighbours; a graph is reducible if such a scheme can eliminate every vertex in the graph. We resolve the square-root conjecture, first posed at MFCS 2004, by showing that for a reducible graph G, the minimum number of required rounds is O(n); in fact, our result is stronger than the conjecture as we show that the minimum number of required rounds is O(α), where α is the independence number of G. This upper bound is tight. We also show that for reducible K1,p-free graphs at most p−1 rounds are required. It is already known that the problem of whether a given graph is reducible is NP-complete. For claw-free graphs, however, we show that this problem can be solved in polynomial time. We also pinpoint a relationship with (locally bijective) graph homomorphisms
Gluon fusion and bb¯ corrections to HW+W−/HZZ production in the POWHEG-BOX

AbstractThe study of the Higgs boson properties is one of the most important tasks to be accomplished in the next years, at the Large Hadron Collider (LHC) and at future colliders such as the Future Circular Collider in hadron–hadron mode (FCC-hh), the potential 100 TeV follow-up of the LHC machine. In this view the precise study of the Higgs couplings to weak gauge bosons is crucial and requires as much information as possible. After the recent calculation of the next-to-leading order QCD corrections to the production cross sections and differential distributions of a Standard Model Higgs boson in association with a pair of weak bosons, matched with parton shower in the POWHEG-BOX framework, we present the gluon fusion correction gg→HW+W−(HZZ) to the process pp→HW+W−(HZZ). This correction can be sizeable and amounts to +3% (+10%) in the HW+W− process and +5% (+18%) in the HZZ process at the LHC (FCC-hh). We also present the first study of the impact of the bottom-quark initiated channels bb¯→HW+W−/HZZ and find that they induce a significant +18% correction in the HW+W− channel at the FCC-hh. We present results on total cross sections and distributions at the LHC and at the FCC-hh
Anti-inflammatory Activity of Calophyllum Inophyllum Fruits Extracts

AbstractIn the present work, we are reporting the isolation. characterisation and bioactvity of inophyllums, xanthones and other compounds found in the fruits of Callophyllum inophyllum. In-vitro assays demonstrated that the crude extract at concentration of 50μg/ml inhibited 77% and 88% cyclooxygenase and lipooxygenase activities, respectively, indicating its potential as anti-inflamatory agent. Phytochemical studies was also conducted on the fruits. Inophyllum A, inophyllum C, inophyllum E, calophylloide, calophynic acid, 11,12-anhydroinophyllum A, 1,7-dihydroxy-6-methoxyxanthone, potocatechuic acid, gallic acid, n-nonacosane, β-sitosterol and sitosterol-3-O-β-D-glucopyranoside were isolated and idetified. On the HPLC chromatogram, at least 18 compounds can be detected
Getting more 'carbon bang' for your 'buck' in Acre State, Brazil

Acre State in Brazil is at the forefront of efforts to institutionalize jurisdictional-scale policies that aim to reduce emissions from deforestation and forest degradation (REDD+). Given limited REDD+ funds and uncertain returns from alternative land uses, this paper estimates the minimum incentive payment Acre’s government would have to pay forest landowners in each of its 22 municipalities to ensure forest conservation. Despite lower profits but with lower conversion costs and more stable returns over time relative to corn and coffee production, cattle pasture generates the highest returns in 19 municipalities. Municipalities are ranked according to their relative policy costs, a ranking which is compared to the distribution of forest carbon stocks across Acre. Finally, the relative cost per tonne of carbon is derived, which enables the identification of a group of 13 municipalities with the greatest potential for ‘carbon bang’ for a given ‘buck’
Falls screening and assessment tools used in acute mental health settings :
                    A review of policies in England and Wales

V. Narayanan, et al, "Falls screening and assessment tools used in acute mental health settings: A review of policies in England and Wales", Physiotherapy, Vol. 102, Issue 2: 178-183, June 2016. ?? 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Objectives: There is an urgent need to improve the care of older people at risk of falls or who experience falls in mental health settings. The aims of this study were to evaluate the individual falls risk assessment tools adopted by National Health Service (NHS) mental health trusts in England and healthcare boards in Wales, to evaluate the comprehensiveness of these tools and to review their predictive validity. Methods: All NHS mental health trusts in England (n = 56) and healthcare boards in Wales (n = 6) were invited to supply their falls policies and other relevant documentation (e.g. local falls audits). In order to check the comprehensiveness of tools listed in policy documents, the risk variables of the tools adopted by the mental health trusts' policies were compared with the 2004 National Institute for Health and Care Excellence (NICE) falls prevention guidelines. A comprehensive analytical literature review was undertaken to evaluate the predictive validity of the tools used in these settings. Results: Falls policies were obtained from 46 mental health trusts. Thirty-five policies met the study inclusion criteria and were included in the analysis. The main falls assessment tools used were the St. Thomas' Risk Assessment Tool in Falling Elderly Inpatients (STRATIFY), Falls Risk Assessment Scale for the Elderly, Morse Falls Scale (MFS) and Falls Risk Assessment Tool (FRAT). On detailed examination, a number of different versions of the FRAT were evident; validated tools had inconsistent predictive validity and none of them had been validated in mental health settings. Conclusions: Falls risk assessment is the most commonly used component of risk prevention strategies, but most policies included unvalidated tools and even well validated tool such as the STRATIFY and the MFS that are reported to have inconsistent predictive accuracy. This raises questions about operational usefulness, as none of these tools have been tested in acute mental health settings. The falls risk assessment tools from only four mental health trusts met all the recommendations of the NICE falls guidelines on multifactorial assessment for prevention of falls. The recent NICE (2013) guidance states that tools predicting risk using numeric scales should no longer be used; however, multifactorial risk assessment and interventions tailored to patient needs is recommended. Trusts will need to update their policies in response to this guidance
Asymptotic Existence of Fair Divisions for Groups

The problem of dividing resources fairly occurs in many practical situations
and is therefore an important topic of study in economics. In this paper, we
investigate envy-free divisions in the setting where there are multiple players
in each interested party. While all players in a party share the same set of
resources, each player has her own preferences. Under additive valuations drawn
randomly from probability distributions, we show that when all groups contain
an equal number of players, a welfare-maximizing allocation is likely to be
envy-free if the number of items exceeds the total number of players by a
logarithmic factor. On the other hand, an envy-free allocation is unlikely to
exist if the number of items is less than the total number of players. In
addition, we show that a simple truthful mechanism, namely the random
assignment mechanism, yields an allocation that satisfies the weaker notion of
approximate envy-freeness with high probability.Comment: To appear in the 10th International Symposium on Algorithmic Game
  Theory (SAGT), 201
Topological vertex for Higgsed 5d TN theories

Journal of High Energy Physics 2015.9 (2015): 023 reproduced by permission of Scuola
Internazionale Superiore di Studi Avanzati (SISSA)We analyse the computation of the partition function of 5d TN theories in
Higgs branches using the topological vertex. The theories are realised by a web of (p, q) 5-
branes whose dual description may be given by an M-theory compactification on a certain
local non-toric Calabi-Yau threefold. We explicitly show how it is possible to directly
apply the topological vertex to the non-toric geometry. Using this novel technique, which
considerably simplifies the computation by the existing method, we are able to compute
the partition function of the higher rank E6, E7 and E8 theories. Moreover we show how
in some specific cases similar results can be extended to the computation of the partition
function of 5d TN theories in the Higgs branch using the refined topological vertex. These
cases require a modification of the refined topological vertexThe work of H.H. and G.Z. is supported by the grant FPA2012-32828 from the MINECO, the REA grant agreement PCIG10-GA-2011-304023 from the People Programme of FP7 (Marie Curie Action), the ERC Advanced Grant SPLE under contract ERC-2012-ADG- 20120216-320421 and the grant SEV-2012-0249 of the “Centro de Excelencia Severo Ochoa” Programme. The work of G.Z. is also supported through a grant from “Campus Excelencia Internacional UAM+CSIC” and partially by the COST Action MP121
Search for supersymmetry in the vector-boson fusion topology in proton-proton collisions at √s = 8 TeV

The first search for supersymmetry in the vector-boson fusion topology is presented. The search targets final states with at least two leptons, large missing transverse momentum, and two jets with a large separation in rapidity. The data sample corresponds to an integrated luminosity of 19.7 fb−1 of proton-proton collisions at √s = 8 TeV collected with the CMS detector at the CERN LHC. The observed dijet invariant mass spectrum is found to be consistent with the expected standard model prediction. Upper limits are set on the cross sections for chargino and neutralino production with two associated jets, assuming the supersymmetric partner of the τ lepton to be the lightest slepton and the lightest slepton to be lighter than the charginos. For a so-called compressed-mass-spectrum scenario in which the mass difference between the lightest supersymmetric particle (Formula presented.) and the next lightest, mass-degenerate, gaugino particles (Formula presented.) and (Formula presented.) is 50 GeV, a mass lower limit of 170 GeV is set for these latter two particles.[Figure not available: see fulltext.] © 2015, The Author(s).The Scientific and Technical Research Council of Turkey, and Turkish Atomic Energy Authorit
Degradation mechanisms of bioresorbable polyesters. Part 2, Effects of initial molecular weight and residual monomer

A.G. acknowledges an EPSRC PhD studentship.This paper presents an understanding of how initial molecular weight and initial monomer fraction affect the degradation of bioresorbable polymers in terms of the underlying hydrolysis mechanisms. A mathematical model was used to analyse the effects of initial molecular weight for various hydrolysis mechanisms including noncatalytic random scission, autocatalytic random scission, noncatalytic end scission or autocatalytic end scission. Different behaviours were identified to relate initial molecular weight to the molecular weight half-life and to the time until the onset of mass loss. The behaviours were validated by fitting the model to experimental data for molecular weight reduction and mass loss of samples with different initial molecular weights. Several publications that consider initial molecular weight were reviewed. The effect of residual monomer on degradation was also analysed, and shown to accelerate the reduction of molecular weight and mass loss. An inverse square root law relationship was found between molecular weight half-life and initial monomer fraction for autocatalytic hydrolysis. The relationship was tested by fitting the model to experimental data with various residual monomer contents