Afanasieff har skrevet og/eller produsert sanger for en rekke artister, inkludert Whitney Houston, Thalía, Lionel Richie, Luther Vandross, George Benson, Destiny's Child, Kenny G, Michael Bolton, Toni Braxton, Darren Hayes (Savage Garden), Andrea Bocelli, Johnny Mathis, Kenny Loggins, Barbra Streisand, Christina Aguilera, Ricky Martin, Marc Anthony, Mika, Babyface, Josh Groban, Jordin Sparks, Tina Arena, Lara Fabian og Leona Lewis.