Buddy Guy har så langt mottatt åtte Grammy Awards og er også i 2023 nominert i klassen Best Traditional Blues Album for . Han har mottatt en rekke hederspriser som for eksempel innlemmelse i Blues Hall of Fame (1985 ), National Medal of Arts (2003), innlemmelse i Rock & Roll Hall of Fame (2005), Lifetime Achievement Award fra The Blues Foundation (2010), Kennedy Center Honours (2012), The National GUITAR Museum Lifetime Achievement Award (2014), Grammy Lifetime Achievement Award (2015) og Americana Music Assn. Lifetime Achievement Award (2018),