En rekke kjente personer spilte gjesteroller i serien, inkludert Edward Asner, Mary Astor, Roscoe Ates, Gene Barry, Ed Begley, Barbara Bel Geddes, Charles Bronson, Edgar Buchanan, Macdonald Carey, Art Carney, John Cassavetes, Jack Cassidy, Dabney Coleman, Tom Conway, Joseph Cotten, Bob Crane, Hume Cronyn, Robert Culp, Bette Davis, Francis De Sales, Bruce Dern, Brandon deWilde, Angie Dickinson, Diana Dors, Robert Duvall, Denholm Elliott, Peter Falk, John Forsythe, Anne Francis, Lorne Greene, Edmund Gwenn, Cedric Hardwicke, Charles Herbert, Wendy Hiller, Skip Homeier, Lou Jacobi, Joyce Jameson, Carolyn Jones, Don Keefer, Brian Keith, Jack Klugman, Jessie Royce Landis, Peter Lawford, Christopher Lee, Cloris Leachman, Peter Lorre, E. G. Marshall, Herbert Marshall, Walter Matthau, Darren McGavin, John McGiver, Lee Majors, Jayne Mansfield, Steve McQueen, Tyler McVey, Audrey Meadows, Joyce Meadows, Vera Miles, Elizabeth Montgomery, Joanna Moore, Roger Moore, Vic Morrow, Leslie Nielsen, Robert Newton, Fess Parker, George Peppard, James Philbrook, Sydney Pollack, Judson Pratt, Robert Redford, Michael Rennie, Burt Reynolds, William Shatner, Dan Sheridan, Henry Silva, Barbara Steele, Jan Sterling, Dean Stockwell, Stella Stevens, Beatrice Straight, Jessica Tandy, Torin Thatcher, Rip Torn, Dick Van Dyke, Robert Vaughn, Richard Waring, Dennis Weaver, Estelle Winwood, Joanne Woodward, Fay Wray og Keenan Wynn.