Chargers' terminliste for -sesongen ble annonsert 7. mai. {| class="wikitable" style="text-align:center" |- !style=""| Uke !style=""| Dato !style=""| Motstander !style=""| Resultat !style=""| Stilling !style=""| Stadion !style=""| OppsummeringNFL.com |-style="background:#cfc" ! 1 | 13. september | at Cincinnati Bengals | 16–13 | 1–0 | Paul Brown Stadium | Oppsummering |-style="background:#fcc" ! 2 | 20. september | | 20–23 | 1–1 | SoFi Stadium | Oppsummering |-style="background:#fcc" ! 3 | 27. september | Carolina Panthers | 16–21 | 1–2 | SoFi Stadium | Oppsummering |-style="background:#fcc" ! 4 | 4. oktober | at Tampa Bay Buccaneers | 31–38 | 1–3 | Raymond James Stadium | Oppsummering |-style="background:#fcc" ! 5 | | at New Orleans Saints | 27–30 | 1–4 | Mercedes-Benz Superdome | Oppsummering |- ! 6 | colspan="6"| SDenver BroncosTLas Vegas RaidersTTSTTSLas Vegas RaidersSDenver BroncosSKansas City ChiefsSMerknaderfet''' tekst.