Etter Milford Academy begynte McCoy på Pittsburgh. Han begynte sesongen som reserve for Larod Stephens-Howling, som var startende running back i 2006 og løp for 890 yards sesongen før. I august 2007 skrev Dave Grdnic for , "After just one week, LeSean McCoy has been as amazing as advertised. He's been dynamic on the field and off, banging up the middle on runs as hard as he bolts around end and talking just as good a game to the media.