Mark Kiszla, en sportsjournalist for , sa at Mannings formue "is estimated to be in excess of $150 million" og "That's not enough money to buy an NFL franchise by himself, although an ownership group that included Manning as president with a financial stake in the team would be led by a brilliant football mind." Han har donert over $8 000 til politikere fra Det republikanske parti, blant andre Fred Thompson, Bob Corker og tidligere president George W. Bush. Under presidentvalget i 2016 donerte Manning til Jeb Bush. Den 26. oktober 2012 kjøpte Manning 21 Papa John's Pizza-restauranter i Colorado. Han solgte sin andel av restaurantene i februar 2018.