Burton er kjent for å gjenbruk av de samme skuespillere i flerfoldige film prosjekter, inkludert Johnny Depp, Helena Bonham Carter, Danny DeVito, Conchata Ferrell, Albert Finney, Carmen Filpi, Michael Gough, Pat Hingle, Jan Hooks, Rance Howard, Jeffrey Jones, O-Lan Jones, Michael Keaton, Martin Landau, Christopher Lee, Lisa Marie, Catherine O'Hara, Michelle Pfeiffer, Vincent Price, Missi Pyle, Paul Reubens, Alan Rickman, Deep Roy, Winona Ryder, Diane Salinger, Glenn Shadix, Martin Short, Timothy Spall, Sylvia Sidney, Christopher Walken, Frank Welker, and Paul Whitehouse.