≡ YOU ARE HERE HOME » SCIENCE » DISEASE AREAS CANCER The Broad Institute’s commitment to finding cures for cancer focuses on scientific research aimed at understanding the molecular mechanisms of each type of cancer and applying this knowledge to transform the clinical practice of cancer medicine. Broad cancer research includes efforts to decipher the genetic and molecular landscape of a wide range of cancer and immune cells as well as equally systematic genome-wide approaches to interrogate the function of cancer genes and the vulnerabilities of tumors. In partnership with colleagues within academia and industry, Broad cancer researchers develop breakthrough technologies to drive discoveries of new drug targets and potential therapies, and generate systematic strategies for predicting therapeutic combinations to combat resistance. The Broad’s interdisciplinary scientific community shares cancer data and ideas freely. This scientific culture propels us to overcome key challenges in cancer biology and cancer therapeutics via both individual and large-scale collaborative research projects that leverage the potent synergy between innovation and scale. As described herein, key areas of focus for Broad cancer researchers include the following: creating a Tumor Atlas and Cancer Dependency Map, enhancing Cancer Genome Interpretation, driving Cancer Therapeutics Discovery, and identifying Combination Therapies to Overcome Resistance. By working together with a wide array of partners, such as scientists and clinicians in academia and industry, cancer patients and advocates, and philanthropists, we aim to rapidly propel scientific discoveries. Our goal is to accelerate the discovery of cancer cures by overcoming key bottlenecks and catalyzing worldwide research efforts. CANCER About Research Highlights Recent Cancer Publications Team Join Us Contact Us AREAS OF FOCUS Tumor Atlas Cancer Genome Interpretation Cancer Dependency Map Cancer Therapeutics Discovery Combination Therapies to Overcome Resistance RECENT PUBLICATIONS Analytical protocol to identify local ancestry-associated molecular features in cancer. Biologically informed deep neural network for prostate cancer discovery. Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer. Duplex-Repair enables highly accurate sequencing, despite DNA damage. Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death. Other Cancer Program Publications RELATED NEW RESEARCH INITIATIVE LAUNCHES FOR ALL PATIENTS EVER DIAGNOSED WITH... Read More NEWS AT THE BROAD ALL NEWS NEWS / 10.28.21 A conversation about the legacy of ENCODE and what comes next READ MORE NEWS / 10.6.21 Richard Merkin, M.D., renews support for transformative science at Broad READ MORE NEWS / 11.15.21 Artificial intelligence–based method predicts risk of atrial fibrillation READ MORE NEWS / 10.13.21 Mapping the effects of genetic variation, one letter at a time READ MORE CAREERS GIVING NEWS AND MEDIA CONTACT US PRIVACY POLICY Copyright © 2021 Broad Institute. All rights reserved. TWITTER FACEBOOK YOUTUBE INSTAGRAM