ABOUT COMPANY PRODUCTS DISTRIBUTORS PRESS CENTER SHAREHOLDERS NEWS CONTACTS ENGLISH QUESTION ANSWER TRIGEXIPHENIDYL ORGANIC Active substance: trihexyphenidil hydrochloride Pharmacological action: trihexyphenidyl belongs to the list of potent substances. It has a central and peripheral m-anticholinergic effect. It has an antispasmodic effect, has a direct depressing effect on the parasympathetic nervous system, as well as a muscle relaxant effect on smooth muscles and reduces the secretion of especially salivary and bronchial glands, reduces sweating. Has a slight effect on the secretion of the pancreas and bile. The effect of the drug occurs within 1 hour after ingestion. The half-life is 6-10 hours. Indications: parkinsonism; prevention and control of drug-induced extra-pyramidal symptoms (with the exception of tardive dyskinesia). Method of administration and dosage: inside, regardless of the time of eating. The tablet is recommended to be taken with a sufficient amount of liquid. The dose must be selected individually, starting with the lowest, increasing it to the minimum effective. With parkinsonism syndromes: the initial dose is 1 mg per day. Every 3-5 days, the dose is gradually increased by 1-2 mg per day to 6-10 mg per day, depending on the patient's response, until the optimal therapeutic effect is obtained. For the treatment of drug-induced extrapyramidal disorders, 5-10 mg of trihexyphenidil is usually prescribed per day, depending on the severity of the symptoms. In some cases, 1 mg daily may be sufficient. Treatment should be completed gradually, reducing the dose of trihexyphenidil for 1-2 weeks, until it is completely canceled. Abrupt withdrawal of the drug can lead to a sudden deterioration in the patient's condition due to exacerbation of the symptoms of the disease. The duration of treatment is determined by the doctor individually in each case. Elderly patients over 65 years of age are prescribed trihexyphenidil in minimal doses of 1-2 mg under the control of cognitive functions and mental state. When trihexyphenidil is used together with other drugs used to treat parkinsonism, a dose reduction is necessary. The maximum single dose is 10 mg, the daily dose is 20 mg. used to treat parkinsonism, dose reduction is necessary. The maximum single dose is 10 mg, the daily dose is 20 mg. used for the treatment of parkinsonism, dose reduction is necessary. The maximum single dose is 10 mg, the daily dose is 20 mg. Contraindications: according to the instructions. Adverse reactions: according to the instructions. Special instructions: Since the use of trihexyphenidil in some cases can last for a long time, the patient should be closely monitored for a long time to avoid allergic or other undesirable reactions. Treatment should not be stopped suddenly. At the end of treatment or in the case of starting an alternative treatment, the dose of trihexyphenidil should be gradually reduced. Intraocular pressure should be monitored periodically. The drug should be used with extreme caution in elderly patients. Release form: tablets 2 mg No. 50. Before use, consult a doctor. For more information, see the instructions for use. HELPFUL INFORMATION The first commercial batch of the antiparkinsonian drug Trihexyphenidil Organic has been produced