PUBLICATIONS 2021 A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease. Wightman DP, Nat Genet. 2021 Sep;53(9):1276-1282. doi: 10.1038/s41588-021-00921-z. Epub 2021 Sep 7.PMID: 34493870 Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Boer CG, Cell. 2021 Sep 2;184(18):4784-4818.e17. doi: 10.1016/j.cell.2021.07.038. Epub 2021 Aug 26.PMID: 34450027 The genomics of heart failure: design and rationale of the HERMES consortium. Lumbers RT ESC Heart Fail. 2021 Sep 3. doi: 10.1002/ehf2.13517. Online ahead of print.PMID: 34480422 Free article. Sequence variants in malignant hyperthermia genes in Iceland: classification and actionable findings in a population database. Fridriksdottir R, Eur J Hum Genet. 2021 Aug 31. doi: 10.1038/s41431-021-00954-2. Online ahead of print.PMID: 34462577 Genetic insights into biological mechanisms governing human ovarian ageing. Ruth KS, Nature. 2021 Aug;596(7872):393-397. doi: 10.1038/s41586-021-03779-7. Epub 2021 Aug 4.PMID: 34349265 Large-Scale Screening for Monogenic and Clinically Defined Familial Hypercholesterolemia in Iceland. Björnsson E, Arterioscler Thromb Vasc Biol. 2021 Aug 19:ATVBAHA120315904. doi: 10.1161/ATVBAHA.120.315904. Online ahead of print.PMID: 34407635 Distinction between the effects of parental and fetal genomes on fetal growth. Juliusdottir T, Nat Genet. 2021 Aug;53(8):1135-1142. doi: 10.1038/s41588-021-00896-x. Epub 2021 Jul 19.PMID: 34282336 Identification of 22 susceptibility loci associated with testicular germ cell tumors. Pluta J, Nat Commun. 2021 Jul 23;12(1):4487. doi: 10.1038/s41467-021-24334-y.PMID: 34301922 Free PMC article. Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits. Beyter D, Nat Genet. 2021 Jun;53(6):779-786. doi: 10.1038/s41588-021-00865-4. Epub 2021 May 10.PMID: 33972781 Molecular benchmarks of a SARS-CoV-2 epidemic. Jonsson H, et al Nat Commun. 2021 Jun 15;12(1):3633. doi: 10.1038/s41467-021-23883-6.PMID: 34131116 Predicting the probability of death using proteomics. Eiriksdottir T, et al Commun Biol. 2021 Jun 18;4(1):758. doi: 10.1038/s42003-021-02289-6.PMID: 34145379 Molecular benchmarks of a SARS-CoV-2 epidemic. Jonsson H, et al Nat Commun. 2021 Jun 15;12(1):3633. doi: 10.1038/s41467-021-23883-6.PMID: 34131116 Predicting the probability of death using proteomics. Eiriksdottir T, et al Commun Biol. 2021 Jun 18;4(1):758. doi: 10.1038/s42003-021-02289-6.PMID: 34145379 Model-based assessment of replicability for genome-wide association meta-analysis. McGuire D, Nat Commun. 2021 Mar 30;12(1):1964. doi: 10.1038/s41467-021-21226-z.PMID: 33785739 Free PMC article. Loss-of-Function Variants in the Tumor-Suppressor Gene PTPN14 Confer Increased Cancer Risk. Olafsdottir T, Cancer Res. 2021 Apr 15;81(8):1954-1964. doi: 10.1158/0008-5472.CAN-20-3065. Epub 2021 Feb 18.PMID: 33602785 Lifelong Reduction in LDL (Low-Density Lipoprotein) Cholesterol due to a Gain-of-Function Mutation in LDLR. Bjornsson E et al Circ Genom Precis Med. 2021 Feb;14(1):e003029. doi: 10.1161/CIRCGEN.120.003029. Epub 2020 Dec 14.PMID: 33315477 The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacements: a large-scale proteomics scan in Iceland. Styrkarsdottir U, et al Arthritis Rheumatol. 2021 May 13. doi: 10.1002/art.41793. Online ahead of print.PMID: 33982893 The genetic structure of Norway. Mattingsdal M, et al. Hum Genet. 2021 May 17. doi: 10.1038/s41431-021-00899-6. Online ahead of print.PMID: 34002043 Cognition in Schizophrenia. Stefansson H, et al. Biol Psychiatry. 2021 Jul 1;90(1):4-5. doi: 10.1016/j.biopsych.2021.05.004.PMID: 34140119 No abstract available. Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs. Sønderby IE, et al. Hum Brain Mapp. 2021 Feb 21. doi: 10.1002/hbm.25354. Online ahead of print.PMID: 33615640 Review. Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs. Sønderby IE, et al. Hum Brain Mapp. 2021 Feb 21. doi: 10.1002/hbm.25354. Online ahead of print.PMID: 33615640 Review. Molecular benchmarks of a SARS-CoV-2 epidemic. Jonsson H, et al Nat Commun. 2021 Jun 15;12(1):3633. doi: 10.1038/s41467-021-23883-6.PMID: 34131116 Predicting the probability of death using proteomics. Eiriksdottir T, et al Commun Biol. 2021 Jun 18;4(1):758. doi: 10.1038/s42003-021-02289-6.PMID: 34145379 Allele frequency of variants reported to cause adenine phosphoribosyltransferase deficiency. Runolfsdottir HL, et al Hum Genet. 2021 Mar 11. doi: 10.1038/s41431-020-00805-6. Online ahead of print.PMID: 33707627 Increased absorption of phytosterols is the simplest and most plausible explanation for coronary artery disease risk not accounted for by non-HDL cholesterol in high cholesterol absorbers. Helgadottir A, et al. Eur Heart J. 2021 Jan 20;42(3):283-284. doi: 10.1093/eurheartj/ehaa902.PMID: 33167008 Free PMC article. No abstract available. Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor. Dowsett J, et al Commun Biol. 2021 Jun 2;4(1):655. doi: 10.1038/s42003-021-02144-8.PMID: 34079037 Free PMC article. Polygenic Risk Score-Enhanced Risk Stratification of Coronary Artery Disease in Patients With Stable Chest Pain. Christiansen MK, et al Circ Genom Precis Med. 2021 Jun;14(3):e003298. doi: 10.1161/CIRCGEN.120.003298. Epub 2021 May 25.PMID: 34032468 Variable number tandem repeats mediate the expression of proximal genes. Bakhtiari M, et al. Nat Commun. 2021 Apr 6;12(1):2075. doi: 10.1038/s41467-021-22206-z.PMID: 33824302 Free PMC article. Germline variants at SOHLH2 influence multiple myeloma risk. Duran-Lozano. et al. Blood Cancer J. 2021 Apr 19;11(4):76. doi: 10.1038/s41408-021-00468-6.PMID: 33875642 Free PMC article. HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry. Konte B, et al Transl Psychiatry. 2021 Apr 12;11(1):214. doi: 10.1038/s41398-021-01322-w.PMID: 33846298 Free PMC article. 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Sønderby IE, et al. Transl Psychiatry. 2021 Mar 22;11(1):182. doi: 10.1038/s41398-021-01213-0.PMID: 33753722 Free PMC article. Analysis of Diffusion Tensor Imaging Data From the UK Biobank Confirms Dosage Effect of 15q11.2 Copy Number Variation on White Matter and Shows Association With Cognition. Biol Psychiatry. 2021 Mar 3:S0006-3223(21)01099-4. doi: 10.1016/j.biopsych.2021.02.969. Online ahead of print.PMID: 33931204 A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Commun Biol. 2021 Feb 3;4(1):156. doi: 10.1038/s42003-020-01575-z.PMID: 33536631 Free PMC article. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Mullins N, et al Nat Genet. 2021 Jun;53(6):817-829. doi: 10.1038/s41588-021-00857-4. Epub 2021 May 17.PMID: 34002096 The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis. Ivarsdottir EV, et al Commun Biol. 2021 Jun 9;4(1):706. doi: 10.1038/s42003-021-02224-9.PMID: 34108613 Identification of genetic loci associated with nocturnal enuresis: a genome-wide association study. Jørgensen CS, et al. Lancet Child Adolesc Health. 2021 Mar;5(3):201-209. doi: 10.1016/S2352-4642(20)30350-3. Epub 2021 Jan 15.PMID: 33453761 PopDel identifies medium-size deletions simultaneously in tens of thousands of genomes. Niehus S, et al Nat Commun. 2021 Feb 1;12(1):730. doi: 10.1038/s41467-020-20850-5.PMID: 33526789 Free PMC article. A polygenic resilience score moderates the genetic risk for schizophrenia. Hess JL, et al Mol Psychiatry. 2021 Mar;26(3):800-815. doi: 10.1038/s41380-019-0463-8. Epub 2019 Sep 6.PMID: 31492941 Free PMC article. Genome-wide association study identifies 48 common genetic variants associated with handedness. Cuellar-Partida G, et al Nat Hum Behav. 2021 Jan;5(1):59-70. doi: 10.1038/s41562-020-00956-y. Epub 2020 Sep 28.PMID: 32989287 Free PMC article. Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs. Sønderby IE, et al. Hum Brain Mapp. 2021 Feb 21. doi: 10.1002/hbm.25354. Online ahead of print.PMID: 33615640 Review. A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy. Skuladottir A, et al. Sci Rep. 2021 Feb 18;11(1):4188. doi: 10.1038/s41598-021-82736-w.PMID: 33602968 Free Loss-of-Function Variants in the Tumor Suppressor Gene PTPN14 confer increased Cancer Risk. Olafsdottir T, et al. Cancer Res. 2021 Feb 18:canres.3065.2020. doi: 10.1158/0008-5472.CAN-20-3065. Online ahead of print.PMID: 33602785 Genetic insight into sick sinus syndrome. Thorolfsdottir RB, et al. Eur Heart J. 2021 Feb 13:ehaa1108. doi: 10.1093/eurheartj/ehaa1108. Online ahead of print.PMID: 33580673 A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Bell S, et al. Commun Biol. 2021 Feb 3;4(1):156. doi: 10.1038/s42003-020-01575-z.PMID: 33536631 Free PMC article. PopDel identifies medium-size deletions simultaneously in tens of thousands of genomes. Niehus S, Jónsson, et al. Nat Commun. 2021 Feb 1;12(1):730. doi: 10.1038/s41467-020-20850-5.PMID: 33526789 Free PMC article. Differences between germline genomes of monozygotic twins. Jonsson H, et al. Nat Genet. 2021 Jan;53(1):27-34. doi: 10.1038/s41588-020-00755-1. Epub 2021 Jan 7.PMID: 33414551 Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Lagou V, et al. Nat Commun. 2021 Jan 5;12(1):24. doi: 10.1038/s41467-020-19366-9.PMID: 33402679 Free PMC article. 2020 Lifelong Reduction in LDL Cholesterol Due to a Gain-of-Function Mutation in LDLR. Björnsson E, et al. Circ Genom Precis Med. 2020 Dec 14. doi: 10.1161/CIRCGEN.120.003029. Online ahead of print.PMID: 33315477 Cerebral small vessel disease genomics and its implications across the lifespan. Sargurupremraj M, et al. Nat Commun. 2020 Dec 8;11(1):6285. doi: 10.1038/s41467-020-19111-2.PMID: 33293549 Large genome-wide association study identifies three novel risk variants for restless legs syndrome. Didriksen M, et al. Commun Biol. 2020 Nov 25;3(1):703. doi: 10.1038/s42003-020-01430-1.PMID: 33239738 Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Steinthorsdottir V, et al. Nat Commun. 2020 Nov 25;11(1):5976. doi: 10.1038/s41467-020-19733-6.PMID: 33239696 Data Resource Profile: The Copenhagen Hospital Biobank (CHB). Sørensen E, et al. Int J Epidemiol. 2020 Nov 10:dyaa157. doi: 10.1093/ije/dyaa157. Online ahead of print.PMID: 33169150 No abstract available. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Surendran P, et al. Nat Genet. 2020 Dec;52(12):1314-1332. doi: 10.1038/s41588-020-00713-x. Epub 2020 Nov 23.PMID: 33230300 A large-scale genome-wide association study meta-analysis of cannabis use disorder. Johnson EC, et al. Lancet Psychiatry. 2020 Dec;7(12):1032-1045. doi: 10.1016/S2215-0366(20)30339-4. Epub 2020 Oct 20.PMID: 33096046 Increased absorption of phytosterols is the simplest and most plausible explanation for coronary artery disease risk not accounted for by non-HDL cholesterol in high cholesterol absorbers. Helgadottir A, et al. Eur Heart J. 2020 Nov 9:ehaa902. doi: 10.1093/eurheartj/ehaa902. Online ahead of print.PMID: 33167008 No abstract available. Habitual sleep disturbances and migraine: a Mendelian randomization study. Daghlas I, et al. Ann Clin Transl Neurol. 2020 Oct 30;7(12):2370-80. doi: 10.1002/acn3.51228. Online ahead of print.PMID: 33125193 MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk. Surakka I, et al. 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Epub 2020 May 11.PMID: 32499649 Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Bryois J, et al. Nat Genet. 2020 May;52(5):482-493. doi: 10.1038/s41588-020-0610-9. Epub 2020 Apr 27.PMID: 32341526 Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Coleman JRI, et al. Mol Psychiatry. 2020 Jul;25(7):1430-1446. doi: 10.1038/s41380-019-0546-6. Epub 2020 Jan 23.PMID: 31969693 Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. Glanville KP, et al. Biol Psychiatry. 2020 Mar 1;87(5):419-430. doi: 10.1016/j.biopsych.2019.06.031. Epub 2019 Aug 5.PMID: 31570195 Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Ntalla I, et al. 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