Careers Contact Services Publications Content News & Events About Publications Services Computational Toxicology (44) Genetic Toxicology (38) In Vitro Toxicology (23) In Vivo Toxicology (48) Pathology & Histology (50) Toxicogenomics (14) Pathology (6) CLEAR ALL Names of ILS employees are shown in boldface font: Migration and Histologic Effects of Visible Implant Elastomer (VIE) and Passive Integrated Transponder (PIT) Tags in the Marine Toad (Rhinella marina) November 14, 2021 Cabot, Megan L., Brigid V. Troan, Kimberly Ange-van Heugten, Rodney W. Schnellbacher, Dustin Smith, Frank Ridgley, and Larry J. Minter Application of open-source PBPK models in rat-to-human pharmacokinetic extrapolation of oral nicotine exposure November 1, 2021 David E Hines, Jingjie Zhang, Xiaoqing Chang, Shannon M. Bell, K. Monica Lee, Phthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans September 23, 2021 Cynthia Willson RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days September 23, 2021 Michael B. Black, Melvin E. Andersen, Salil N. Pendse, Susan J. Borghoff, Michael Streicker, Patrick D. McMullen Application of open-source PBPK models in rat-to-human pharmacokinetic extrapolation of oral nicotine exposure August 27, 2021 David E Hines, Jingjie Zhang, Xiaoqing Chang, Shannon M. Bell, K. Monica Lee A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures August 18, 2021 Buick Julie K., Williams Andrew, Meier Matthew J., Swartz Carol D., Recio Leslie, Gagné Rémi, Ferguson Stephen S., Engelward Bevin P., Yauk Carole L. Immunotoxicity studies of sulfolane following developmental exposure in Hsd:Sprague Dawley SD rats and adult exposure in B6C3F1/N mice August 6, 2021 AtLee T. D. Watson, Victor J. Johnson, Michael I. Luster, Gary R. Burleson, Dawn M. Fallacara, Barney R. Sparrow, Mark F. Cesta, Michelle C. Cora, Keith R. Shockley, Matt D. Stout, Chad R. Blystone, Dori R. Germolec Effects of Buprenorphine, Chlorhexidine, and Low-level Laser Therapy on Wound Healing in Mice June 29, 2021 Donna R Webb, Sheba R Churchill, Georgette D Hill, Christopher A McGee, Min Shi, Angela P King-Herbert, Terry L Blankenship-Paris Urinary polycyclic aromatic hydrocarbon metabolites and mortality in the United States: A prospective analysis June 4, 2021 Achal P. Patel, Suril S. Mehta, Alexandra J. White, Nicole M. Niehoff, Whitney D. Arroyave, Amy Wang, Ruth M. Lunn The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma April 21, 2021 Chuancang Jiang, Ming-Lang Zhao, Luis Ramos, Katarzyna Dobaczewska, Ronald Herbert, Kristen Hobbie, Zbigniew Mikulski, Laurent Verkoczy and Marilyn Diaz Human-Relevant Approaches to Assess Eye Corrosion/Irritation Potential of Agrochemical Formulations April 8, 2021 Amy J Clippinger, Hans A Raabe, David G Allen, Neepa Choksi, Anna van der Zalm, Nicole Kleinstreuer, João Barroso, Anna Lowit alpha-Glycosyl Isoquercitrin (AGIQ) and its lack of carcinogenicity in rasH2 mice April 2, 2021 Debabrata Mahapatra, Douglas A. Donahue, Abraham Nyska, Shim-mo Hayashi, Mihoko Koyanagi, Robert R. Maronpot Disposition and metabolism of ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, and in vitro in rat hepatocytes March 26, 2021 AtLee T. D. Watson, Benjamin C. Moeller, Melanie Doyle-Eisele, Edwin Garner, Chad R. Blystone, Jacob D. McDonald & Suramya Waidyanatha Retrospective analysis of dermal absorption triple pack data March 17, 2021 Allen, D. G., Rooney, J., Kleinstreuer, N. ., Lowit, A. and Perron, M. Absence of genotoxicity of purified Aloe vera whole leaf dry juice as assessed by an in vitro mouse lymphoma tk assay and an in vivo comet assay in male F344 rats March 16, 2021 Jiang Hu, Mel Lloyd, Cheryl Hobbs, Peter Cox, Keith Burke, Gareth Pearce, Michael A. Streicker, Quanyin Gao, Vasilios Frankos Cockroach exposure and perceived stress interact to predict clinical outcomes in childhood asthma March 12, 2021 Felicia A. Rabito, Derek Werthmann, Hua He, Aubrey S. Madkour, Whitney D. Arroyave, Michelle L. Sever, Thomas A. LaVeist Recommendations for conducting the rodent erythrocyte Pig-a assay: A report from the HESI GTTC Pig-a Workgroup February 20, 2021 Stephen D Dertinger, Javed A Bhalli, Daniel J Roberts, Leon F Stankowski Jr, B Bhaskar Gollapudi, David P Lovell , Leslie Recio, Takafumi Kimoto, Daishiro Miura, Robert H Heflich Transcriptomic pathway and benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3′,5,5′-Tetrabromobisphenol A in H9 human embryonic stem cells January 25, 2021 Vian Peshdary, Cheryl A. Hobbs, Timothy Maynorc, Kim Shepard, Remi Gagné, Andrew Williams, Byron Kuo, Nikolai Chepelev, Leslie Recio, Carole Yauk, Ella Atlas A modified silent substitution electroretinography protocol to separate photoreceptor subclass function in lightly sedated dogs January 24, 2021 E N Wise, M L Foster, J Kremers, F M Mowat Mind the gaps: Prioritizing activities to meet regulatory needs for acute systemic lethality January 21, 2021 Sullivan, K., Allen, D. G., Clippinger, A. J., Wilson, D. M., Edwards, S. W., Glover, K., Mansouri, K., Settivari, R., Wijeyesakere, S. J. and Casey, W. Training with Multiple Structurally Related Odorants Fails to Improve Generalization of Ammonium Nitrate Detection in Domesticated Dogs (Canis Familiaris) January 16, 2021 David C Dorman, Melanie L Foster, Lucia Lazarowski Using the monocyte activation test as a stand-alone release test for medical devices January 12, 2021 Brown, J., Clippinger, A. J., Fritz Briglia, C. ., Casey, W., Coleman, K., Fritsch, A., Hartung, T., Maouyo, D., Muller, T., Reich, J., Robert, L., Roeder, R., Sanchez, G., Sawyer, A. Y., Solati, S., Tirumalai, R., Zwisler, W. and Allen, D. Using Artificial Intelligence to Detect, Classify, and Objectively Score Severity of Rodent Cardiomyopathy December 9, 2020 Debra A. Tokarz, Thomas J. Steinbach, Avinash Lokhande, Gargi Srivastava, Rajesh Ugalmugle, Caroll A. Co, Keith R. Shockley, Emily Singletary, Mark F. Cesta, Heath C. Thomas, Vivian S. Chen, Kristen Hobbie, Torrie A. Crabbs A weight of evidence assessment of the genotoxicity of 2,6-xylidine based on existing and new data, with relevance to safety of lidocaine exposure. December 7, 2020 David J. Kirkland, Meredith, L. Sheil, Michael A. Streicker, George E. Johnson Assessing Rodent Gnawing of Elastomers Containing Soybean Oil Derivatives December 7, 2020 Richard P. Heggs, Brian C. Pierce, Lisa M. Balbes, Keenan C. McRoberts, Michael A. Streicker, and Keith B. Cockerline An evaluation of the performance of selected (Q)SARs/expert systems for predicting acute oral toxicity. November 1, 2020 Nelms MD, Karmaus AL, Patlewicz G Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms October 16, 2020 Wetendorf M, R Li, SP Wu, J Liu, CJ Creighton, T Wang, KS Janardhan, CJ Willson, RB Lanz, BD Murphy, JP Lydon and FJ DeMayo Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish October 1, 2020 Megan M. Knuth, Debabrata Mahapatra, Dereje Jima, Debin Wan, Bruce D. Hammock, Mac Law & Seth W. Kullman Risk of Bias Assessments and Evidence Syntheses for Observational Epidemiologic Studies of Environmental and Occupational Exposures: Strengths and Limitations September 18, 2020 Kyle Steenland, M.K. Schubauer-Berigan, R. Vermeulen, R.M. Lunn, K. Straif, S. Zahm, P. Stewart, W.D. Arroyave, S.S. Mehta, and N. Pearce Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats June 23, 2020 Kristen R. Hobbie, Darlene Dixon An integrated chemical environment with tools for chemical safety testing June 14, 2020 Bell S, Abedini J, Ceger P, Chang X, Cook B, Karmaus AL, Lea, I, Mansouri K, Phillips J, McAfee E, Rai R, Rooney J, Sprankle C, Tandon A, Allen D, Casey W, and Kleinstreuer N Challenges and recommendations on the conduct of systematic reviews of observational epidemiologic studies in environmental and occupational health June 11, 2020 Whitney D. Arroyave, Suril S. Mehta, Neela Guha, Pam Schwingl, Kyla W. Taylor, Barbara Glenn, Elizabeth G. Radke, Nadia Vilahur, Tania Carreón, Rebecca M. Nachman & Ruth M. Lunn https://www.nature.com/articles/s41370-020-0228-0 Development, Validation and Integration of in Silico Models to Identify Androgen Active Chemicals June 9, 2020 Serena Manganelli, Alessandra Roncaglioni, Kamel Mansouri, Richard S Judson, Emilio Benfenati, Alberto Manganaro, Patricia Ruiz Retinal cone photoreceptor distribution in the American black bear (Ursus americanus) June 8, 2020 Jennifer L. Heyward Benjamin D. Reynolds Melanie L. Foster Kate E. Archibald Michael K. Stoskopf Freya M. Mowat Developmental Exposure of Zebrafish to Vitamin D Receptor Acting Drugs and Environmental Toxicants Disrupts Behavioral Function June 5, 2020 Anthony Oliveri , Lilah Glazer, Debabrata Mahapatra, Seth Kullman, Edward D Levin In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice May 29, 2020 Karina Rodriguez, Namya Mellouk, Erica Ungewitter, Barbara Nicol, Chang Liu, Paula R. Brown, Cynthia J. Willson, Humphrey H.-C.Yao Detection of circulating anti-retinal antibodies in dogs with sudden acquired retinal degeneration syndrome using indirect immunofluorescence: A case-control study April 8, 2020 Freya M Mowat, Janelle Avelino, Ashley Bowyer, Vanessa Parslow, Hans D Westermeyer, Melanie L Foster, Jonathan E Fogle, Petra Bizikova Multigenerational Reproductive Assessment of 4-Methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats March 31, 2020 Mamta Behl, Cynthia J. Willson, Helen Cunny, Paul M.D.Foster, Barry McIntyre, Cynthia Shackelford, Keith R. Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha, Chad R. Blystone Methods for Cryosectioning and Mass Spectrometry Imaging of Whole-Body Zebrafish March 19, 2020 Whitney L. Stutts, Megan M. Knuth, Måns Ekelöf, Debabrata Mahapatra, Seth W. Kullman, David C. Muddiman New Perspectives for Cancer Hazard Evaluation by the Report on Carcinogens: A Case Study Using Read-Across Methods in the Evaluation of Haloacetic Acids Found as Water Disinfection By-Products December 19, 2019 Stanley T. Atwood, Ruth M. Lunn, Sanford C. Garner, and Gloria D. Jahnke A Prospective Analysis of Red and Processed Meat Consumption and Risk of Colorectal Cancer in Women December 16, 2019 Suril S. Mehta, Whitney D. Arroyave, Ruth M. Lunn, Yong-Moon Mark Park, Windy A. Boyd and Dale P. Sandler Previously Diagnosed Reticulum Cell Hyperplasia in Decalcified Rat Bone Marrow Stain Positive for Ionized Calcium Binding Adapter Molecule 1 (Iba1): A Monocytic/Macrophage Cell Marker December 12, 2019 Michelle C. Cora, Kyathanahalli S. Janardhan, Heather Jensen, Natasha Clayton, Gregory S. Travlos Proceedings of the 2019 National Toxicology Program Satellite Symposium November 1, 2019 Susan A. Elmore, Mark F. Cesta, Torrie A. Crabbs, Kyathanahalli S. Janardhan, Gregory A. Krane, Debabrata Mahapatra, Erin M. Quist, Matthias Rinke, George W. Schaaf, Gregory S. Travlos, Haoan Wang, Cynthia J. Willson, and Jeffrey C. Wolf Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace October 14, 2019 Wan-Chi Lin, Kymberly M. Gowdy, Jennifer H. Madenspacher, Rachel L. Zemans, Kazuko Yamamoto, Miranda R. Lyons-Cohen, Hideki Nakano, Kyathanahalli Janardhan, Carmen J. Williams, Donald N. Cook, Joseph P. Mizgerd, and Michael B. Fessler Integrated in silico and in vitro genotoxicity assessment of thirteen data-poor substances. October 14, 2019 Tran YK, Buick JK, Keir JLA, Williams A, Swartz CD , Recio L, White PA, Lambert IB, Yauk CL National Toxicology Program Position Statement on Informed (“Nonblinded”) Analysis in Toxicologic Pathology Evaluation September 20, 2019 Robert C. Sills, Mark F. Cesta, Cynthia J. Willson, Amy E. Brix, Brian R. Berridge Looking Forward: Cutting-Edge Technologies and Skills for Pathologists in the Future September 17, 2019 Kyathanahalli S. Janardhan, Rebecca Kohnken, Oliver C. Turner, Channabasavaiah B. Gurumurthy, Ramesh C. Kovi Comparative Incidences and Biological Outcomes for Thymoma in Various Rat Strains in National Toxicology Program Studies. August 13, 2019 Moore RR, Nagai H, Miller RA, Hardisty JF, Allison N, Shockley KR, Malarkey DE Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis July 31, 2019 Pengcheng Chen, Shang Wang, Kyathanahalli S. Janardhan, Rachel L. Zemans, Wenhai Deng, Peer Karmaus, Shudan Shen, Mary Sunday, Loretta G. Que, Michael B. Fessler and Xiao-Ping Zhong ERBB2 Regulates MED24 during Cancer Progression in Mice with Pten and Smad4 Deletion in the Pulmonary Epithelium July 31, 2019 Jian Liu, Tianyuan Wang, Cynthia J. Willson, Kyathanahalli S. Janardhan, San-Pin Wu, Jian-Liang Li and Francesco J. DeMayo Do GISTs Occur in Rats and Mice? Immunohistochemical Characterization of Gastrointestinal Tumors Diagnosed as Smooth Muscle Tumors in The National Toxicology Program July 31, 2019 Kyathanahalli S. Janardhan, Priyanka Venkannagari, Heather Jensen, Mark J. Hoenerhoff, Ronald A. Herbert, David E. Malarkey, Robert C. Sills, Arun R. Pandiri JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression July 31, 2019 Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis & Francesco J. DeMayo Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD) July 31, 2019 Folami Y Ideraabdullah, Anthony M Belenchia, Cheryl S Rosenfeld, Seth W Kullman, Megan Knuth, Debabrata Mahapatra, Michael Bereman, Edward D Levin, and Catherine A Peterson Proceedings of the 2018 National Toxicology Program Satellite Symposium October 8, 2018 Susan A. Elmore, Vinicius Carreira, Caralyn S. Labriola, Debabrata Mahapatra, Sean R. McKeag, Matthias Rinke, Cynthia Shackelford, Bhanu Singh, Ashley Talley, Shannon M. Wallace, Lyn M. Wancket, Cynthia J. Willson Differentiating between Testicular Toxicity and Sexual Immaturity in Ortho-phthalaldehyde Inhalation Toxicity Studies in Rats and Mice October 8, 2018 Natasha R. Catlin, Cynthia J. Willson, Dianne M. Creasy, Deepa B. Rao, Grace E. Kissling, Barry S. McIntyre, Michael Wyde Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays June 11, 2018 Debabrata Mahapatra, Jill A. Franzosa, Kyle Roell, Melaine Agnes Kuenemann, Keith A. Houck, David M. Reif, Denis Fourches & Seth W. Kullman Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin June 4, 2018 Cheryl Hobbs, Mihoko Koyanagi, Carol Swartz, Jeffrey Davis, Robert Maronpot, Leslie Recio, Shim-mo Hayashi Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice May 14, 2018 J.K. Dunnick, A.R. Pandiri, B.A. Merrick, G.E. Kissling, H. Cunny, E. Mutlu, S. Waidyanatha, R. Sills, H.L. Hong, TV. Ton, T. Maynor, L. Recio, S.L. Phillips, M.J. Devito, A. Brix Role of pathology peer review in interpretation of the comet assay May 11, 2018 R. R. Maronpot, Cheryl A. Hobbs, Shim-mo Hayashi Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells April 25, 2018 Stephanie L. Smith‐Roe, Carol D. Swartz, Kim G. Shepard, Steven M. Bryce, Stephen D. Dertinger, Suramya Waidyanatha, Grace E. Kissling, Scott S. Auerbach, Kristine L. Witt Transcriptional profiling of male CD-1 mouse lungs and harderian glands supports the involvement of calcium signaling in acrylamide-induced tumors February 26, 2018 Nikolai L. Chepelev⁠a, Rémi Gagné⁠, Timothy Maynor⁠, Byron Kuo⁠, Cheryl A. Hobbs⁠, Leslie Recio⁠, Carole L. Yauk⁠ Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential February 26, 2018 Cheryl A. Hobbs, Kazuhiko Saigo, Mihoko Koyanagi, Shim-mo Hayashi Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential February 23, 2018 Cheryl A. Hobbs, Mihoko Koyanagi, Carol Swartz, Jeffrey Davis, Sawako Kasamoto, Robert Maronpot, Leslie Recio, Shim-mo Hayashi Comparative inhalation toxicity of ethyltoluene isomers in rats and mice January 29, 2018 Georgia K. Roberts, Cynthia J. Willson, Dorian S. Olivera, David E. Malarkey & Daniel L. Morgan In Vitro to In Vivo extrapolation for high throughput prioritization and decision making January 3, 2018 Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes N, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC. 2017. In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicology In Vitro. 2017 Dec 5. doi:10.1016/j.tiv.2017.11.016 Open-source Workflows for In Vitro to In Vivo Extrapolation March 16, 2017 X Chang, SM Bell, JR Pirone, D Allen, W Casey, N Kleinstreuer. 2017. Open-source Workflows for In Vitro to In Vivo Extrapolation. Presented at SOT Annual Meeting on March 16, 2017 (Abstract # 3185 ) Development of a Curated Database of In Vivo Developmental Toxicity Data March 16, 2017 P Ceger, N Choksi, J Hamm, J Truax, A Daniel, D Allen, V Sutherland, B McIntyre, P Foster, E Maull, W Casey. 2017. Development of a Curated Database of In Vivo Developmental Toxicity Data. Presented at SOT Annual Meeting on March 16, 2017 (Abstract #3159) Impact of Acrylamide on Calcium Signaling and Cytoskeletal Filaments in Testes From F344 Rat. March 16, 2017 Leslie Recio, Marvin Friedman, Dennis Marroni, Timothy Maynor, Nikolai Chepelev An Integrated Chemical Environment to Support 21st Century Toxicology March 15, 2017 SM Bell, J Phillips, A Sedykh, C Sprankle, S Morefield, D Allen, W Casey, N Kleinstreuer. 2017. An Integrated Chemical Environment to Support 21st Century Toxicology. Presented at SOT Annual Meeting on March 15, 2017 (Abstract # 2935) Prediction of Skin Sensitization Potency Using Machine Learning Approaches March 15, 2017 J Strickland, Q Zang, M Paris, DM Lehmann, S Bell, D Allen, J Matheson, A Jacobs, W Casey, N Kleinstreuer. 2017. Prediction of Skin Sensitization Potency Using Machine Learning Approaches. Presented at SOT Annual Meeting on March 15, 2017 (Abstract #2915) Identification, Curation, and Prioritization of Food-Use Chemicals in ToxCast March 15, 2017 M Krishan, TD Trautman, DF Kapraun, LA Fix, and AL Karmaus. 2017. Identification, Curation, and Prioritization of Food-Use Chemicals in ToxCast. Presented at SOT Annual Meeting on March 15, 2017 (Abstract #2559) In Vitro Micronucleus and CometChip with Metabolically Competent HepaRG Cells March 14, 2017 Swartz, CD, Winters, J, Owens, K, Yauk, CL, Buick, J, Ngo, L, Engelward, B, and Recio, L. 2017. In Vitro Micronucleus® and CometChip with Metabolically Competent HepaRG™ Cells. Presented at SOT Annual Meeting on March 14, 2017 (Abstract # 2267) Acrylamide Perturbs Calcium and Actin Cytoskeleton Signaling in Rat and Mouse Cancer Target Tissues March 14, 2017 Chepelev NL, Gagné R, Maynor T, Hobbs CA, Kuo B, Yauk CL, Recio L. 2017. Acrylamide Perturbs Calcium and Actin Cytoskeleton Signaling in Rat and Mouse Cancer Target Tissues. Presented at SOT Annual Meeting on March 14, 2017 (Abstract # 1830) Customizing the Connectivity Map Approach for Functional Evaluation in Toxicogenomics Studies March 13, 2017 Karmaus AL, Kothiya P, Watford S, Thomas RS, Martin MT. 2017. Customizing the Connectivity Map Approach for Functional Evaluation in Toxicogenomics Studies. Presented at SOT Annual Meeting on March 13, 2017 (Abstract #1374) Toxicogenomics Reveals Dynamic Baseline Changes and Overlapping Effects of Epigenotoxicant Exposure on Stem Cell Differentiation and Tissue Development Networks March 13, 2017 Hobbs CA, Sinha N, Chepelev N, Gagné R, Christy N, Yauk CL, Recio L. 2017. Toxicogenomics Reveals Dynamic Baseline Changes and Overlapping Effects of Epigenotoxicant Exposure on Stem Cell Differentiation and Tissue Development Networks. Presented at SOT Annual Meeting on March 13, 2017 (Abstract #1344) Ninety-day toxicity and single-dose toxicokinetics study of AGIQ in Sprague-Dawley rats September 27, 2016 Nyska A, Hayashi S, Koyanagi M, Davis J, Jokinen M, Ramot Y, Maronpot R. 2016. Ninety-day toxicity and single-dose toxicokinetics study of alphaglycosyl isoquercitrin in Sprague-Dawley rats. Food and Chemical Toxicology. 2016 Sep 27. pii: S0278-6915(16)30346-5. Genotoxicity assessment of the flavouring agent, perillaldehyde September 1, 2016 Hobbs C, Taylor S, Beevers C, Lloyd M, Bowen R, Lillford L, Maronpot R, Hayashi S. 2016. Genotoxicity assessment of the flavouring agent, perillaldehyde. Food and Chemical Toxicology. 2016 Sep 1;97:232-242. doi: 10.1016/j.fct.2016.08.029. Chemical Reactivity and Respiratory Toxicity of the alpha-Diketone Flavoring Agents July 1, 2016 Morgan D, Jokinen M, Johnson C, Price H, Gwinn W, Bousquet R, Flake G. 2016. Chemical Reactivity and Respiratory Toxicity of the alpha-Diketone Flavoring Agents: 2,3-Butanedione, 2,3-Pentanedione, and 2,3-Hexanedione. Toxicologic Pathology. 2016 Jul;44(5):763-83. doi: 10.1177/0192623316638962. Differential genotoxicity of acrylamide in the MN and Pig-a assays in F344 rats and B6C3F1 mice June 23, 2016 Hobbs CA, Davis J, Shepard K, Chepelev N, Friedman M, Marroni D, Recio L. 2016. Differential genotoxicity of acrylamide in the micronucleus and Pig-a gene mutation assays in F344 rats and B6C3F1 mice. Mutagenesis. 2016 Jun 23. pii: gew028 Advancing toxicology research using in vivo high throughput toxicology with small fish models June 21, 2016 Planchart A, Mattingly CJ, Allen D, Ceger P., Casey W, Hinton D, Kanungo J, Kullman SW, Tal T, Bondesson M, Burgess SM, Sullivan C, Kim C, Behl M, Padilla S, Reif DM, Tanquay RL, Hamm J. 2016. Advancing toxicology research using in vivo high throughput toxicology with small fish models. Altex. 2016 Jun 21. doi: 10.14573/altex.1601281. Integrated decision strategies for skin sensitization hazard March 14, 2016 Strickland J, Zang Q, Kleinstreuer N, Paris M, Lehmann DM, Choksi N, Matheson J, Jacobs A, Lowit A, Allen D, Casey W. 2016. Integrated decision strategies for skin sensitization hazard. Journal of Applied Toxicology. 2016 Feb 6. doi: 10.1002/jat.3281. Accelerating adverse outcome pathway development using publicly available data sources March 14, 2016 Oki NO, Nelms MD, Bell SM, Mortensen HM, Edwards SW. 2016. Accelerating adverse outcome pathway development using publicly available data sources. Curr Environ Health Rep. 2016 Mar;3(1):53-63. Adverse Outcome Pathways: From Research to Regulation. Scientific workshop report March 14, 2016 Kleinstreuer NC, Sullivan K, Allen D, Edwards S, Mendrick DL, Embry M, Matheson J, Rowlands JC, Munn S, Maull E, Casey W. 2016. Adverse Outcome Pathways: From Research to Regulation. Scientific workshop report. Regulatory Toxicology & Pharmacology. 2016 Jan 14;76:39-50 doi: 10.1016/j.yrtph.2016.01.007 Enhanced stability of TTP mRNA protects mice against immune-mediated inflammatory pathologies February 8, 2016 Patial S, Curtis AD, Lai WS, Stumpo DJ, Hill GD, Flake GP, Mannie MD, Blackshear PJ. Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. Proc Natl Acad Sci U S A. 2016 Feb 1. pii: 201519906. Performance of the BG1Luc ER TA method in a qHTS format February 8, 2016 Ceger P, Allen D, Huang R, Xia M, Casey W. Performance of the BG1Luc ER TA method in a qHTS format. ALTEX. 2015 Jun 28. doi: 10.14573/altex.1505121 Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis December 14, 2015 Ippolito DL, AbdulHameed MD, Tawa GJ, Baer CE, Permenter MG, McDyre BC, Dennis WE, Boyle MH, Hobbs CA, Streicker MA , Snowden BS, Lewis JA, Wallqvist A, Stallings JD.Gene expression patterns associated with histopathology in toxic liver fibrosis. Toxicol Sci. 2015 Sep 22. pii: kfv214. Bayesian Integrated Testing Strategy (ITS) for Skin Sensitization Potency Assessment December 8, 2015 Jaworska JS,· Natsch A, Ryan C, · Strickland J, ·Ashikaga T, · Miyazawa M. 2015. Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy. Arch Toxicol. 2015 Dec; doi: 10.1007/s00204-015-1634-2 Utilizing Whole Slide Images for Pathology Peer Review and Working Groups November 13, 2015 Malarkey DE, Willson GA, Willson CJ, Adams ET, Olson GR, Witt WM, Elmore SA, Hardisty JF, Boyle MC, Crabbs TA, Miller RA. (2015) Utilizing Whole Slide Images for Pathology Peer Review and Working Groups. Toxicol Pathol. 2015 Oct 27. pii: 0192623315605933 IHC Expression of Cyclin D1, Cytokeratin 20, & Uroplakin III Induced by o-Nitroanisole October 6, 2015 Cynthia J. Willson, Gordon P. Flake, Robert C. Sills, Grace E. Kissling, and Mark F. Cesta. (2015) Immunohistochemical Expression of Cyclin D1, Cytokeratin 20, and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by o-Nitroanisole in Fischer 344/N Rats. Veterinary Pathology, first published on August 28, 2015 as doi:10.1177/0300985815603432 Integration of metabolic activation w TGx signature to classify genotoxic vs nongenotoxic chemicals October 6, 2015 J.K. Buick, I. Moffat, A. Williams, C.D. Swartz, L. Recio, D. R. Hyduke, H.H. Li, A.J. Fornace Jr, J. Aubrecht, C.L. Yauk. (2015) Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells. Environ Mol Mutagen 56:520–534. doi.org/10.1002/em.21940. PMID: 25733247 A predictive TGx signature to classify genotoxic vs non-genotoxic chemicals in human TK6 cells October 6, 2015 Andrew Williams, Julie K. Buick, Ivy Moffat, Carol D. Swartz, Leslie Recio, Daniel R. Hyduke, Heng-Hong Li, Albert J. Fornace Jr., Jiri Aubrecht, Carole L. Yauk. (2015) A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells. Data in Brief. doi:10.1016/j.dib.2015.08.013 Impact of Genomics Platform & Statistics on Transcriptional BMD & Selection of Chemical PoD October 6, 2015 Webster AF, Chepelev N, Gagné R, Kuo B, Recio L, Williams A, Yauk CL. (2015) Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD). PLoS One. Aug 27;10(8):e0136764. doi: 10.1371/journal.pone.0136764. PMID: 26313361 TGx & traditional approaches to inform MoA and PoD in health risk assessment of benzo[a]pyrene October 6, 2015 Moffat I, Chepelev NL, Labib S, Bourdon-Lacombe J, Kuo B, Buick JK, Lemieux F, Williams A, Halappanavar S, Malik AI, Luijten M, Aubrecht J, Hyduke DR, Fornace AJ Jr, Swartz CD, Recio L, Yauk CL. (2015) Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. 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Mutation Research. 2015 Apr. 29 Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis April 7, 2015 Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes.Hall JR, Messenger ZJ, Tam HW, Phillips SL, Recio L, Smart RC. Cell Death Dis. 2015 Mar 19 Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice April 7, 2015 Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice exposed to the carcinogen furan. Recio L, Phillips SL, Maynor T, Waters M , Jackson AF, Yauk CL. Toxicol Sci. 2013 Oct;135(2):369-79. Comet assay evaluation of six chemicals of known genotoxic potential in rats April 1, 2015 Hobbs CA L. Recio L, Streicker M, Boyle M , Tanaka J, Shiga A, Witt KL. Genet. Toxicol. Environ. Mutagen. (2015). 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Part I: QSAR models of skin sensitization January 20, 2015 Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer NC, Andrade CH, Tropsha A. (2015) Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds. Toxicology and Applied Pharmacology, t4 workshop report: Integrated Testing Strategies (ITS) for Safety Assessment ALTEX December 5, 2014 Rovida C, Alépée N, Api AM, Basketter DA, Bois FY, Caloni F, Corsini E, Daneshian M, Eskes C, Ezendam J, Fuchs H, Hayden P, Hegele-Hartung C, Hoffmann S, Hubesch B, Jacobs MN, Jaworska J, Kleensang A, Kleinstreuer N, Lalko J, Landsiedel R, Lebreux F, Luechtefeld T, Locatelli M, Mehling A, Natsch A, Pitchford JW, Prater D, Prieto P, Schepky A, Schuurmann G, Smirnova L, Toole C, van Vliet E, Weisensee D, Hartung T. 2014. t4 workshop report: Integrated Testing Strategies (ITS) for Safety Assessment ALTEX (in press). Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity December 5, 2014 Chang X, Kleinstreuer N, Ceger P, Hsieh J-H, Allen D, Casey W. Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity. Applied In Vitro Toxicology (in press). Immediate and long-term consequences of vascular toxicity during zebrafish development December 5, 2014 Tal TL, McCollum CW, Harris PS, Olin J, Kleinstreuer N, Wood CE, Hans C, Shah S, Merchant FA, Bondesson M, Knudsen TB, Padilla S, Hemmer MJ. 2014. Immediate and long-term consequences of vascular toxicity during zebrafish development. Reprod Toxicol 48:51–61. Open source software implementation of an integrated testing strategy for skin sensitization potency December 5, 2014 Pirone JR, Smith M, Kleinstreuer NC, Burns TA, Strickland J, Dancik Y, Morris R, Rinckel LA, Casey W, Jaworska JA. 2014. Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network. ALTEX 31: 336–340. Comments how to make the new vision of toxicity testing in the 21st century a reality December 5, 2014 McKim A, Goldberg A, Kleinstreuer N, Busquet F, Andersen M. 2014. Roundtable discussion: Comments on how to make the new vision of toxicity testing in the 21st century a reality. Applied In Vitro Toxicology 1(1): 5–10. t4 workshop report: Lessons Learned, Challenges, and Opportunities: The U.S. EDSP December 5, 2014 Juberg DR, Borghoff SJ, Becker RA, Casey W, Hartung T, Holsapple MP, Marty MS, Mihaich EM, Van Der Kraak G, Wade MG, Willett CE, Andersen ME, Borgert CJ, Coady KK, Dourson ML, Fowle JR, Gray LE, Lamb JC, Ortego LS, Schug TT, Toole CM, Zorrilla LM, Kroner OL, Patterson J, Rinckel LA, Jones BR. 2014. t4 workshop report: Lessons Learned, Challenges, and Opportunities: The U.S. Endocrine Disruptor Screening Program. ALTEX 31:63-78. Report on the International Workshop on Alternatives to the Murine Histamine Sensitization Test December 5, 2014 Isbrucker R, Arciniega J, McFarland R, Chapsal J-M, Xing D, Bache C, Nelson S, Costanzo A, Hoonakker M, Castiaux A, Halder M, Casey W, Johnson N, Jones B, Doelling V, Sprankle C, Rinckel L, Stokes W. 2014. Report on the International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward. Biologicals 42(2):114-122. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor December 5, 2014 Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh J-H, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, Shinn P, Simeonov A, Dix DJ, Austin CP, Kavlock RJ, Tice RR, Xia M. 2014. 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August 28, 2013 Kolle SN, Basketter DA, Casati S, Stokes WS, Strickland J, van Ravenzwaay B, Vohr HW, and Landsiedel R. 2013. Performance standards and alternative assays: Practical insights from skin sensitization. Regul Toxicol Pharmacol 65: 278-85. A computational model predicting disruption of blood vessel development. August 28, 2013 Kleinstreuer N, Dix D, Rountree M, Baker N, Sipes N, Reif D, Spencer R, Knudsen T. (2013) A Computational Model Predicting Disruption of Blood Vessel Development. PLoS Comput Biol 9(4): e1002996. Meeting Report: Urinary Pathology; Sixth Research Triangle Park Rodent Pathology Course June 3, 2013 Boyle MC, Boyle MH, and the Sixth Rodent Pathology Course Committee. 2013. Meeting Report: Urinary Pathology; Sixth Research Triangle Park Rodent Pathology Course. Vet. Pathol. 50(3): 563-8. Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform. 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Evaluation of 90-day oral rat toxicity studies on the food additive, gum ghatti. Food and Chemical Toxicology, 51: 215-224. Report on the International Workshop on Alternative Methods for Human & Veterinary Rabies Vaccines August 14, 2012 Stokes W, McFarland R, Kulpa-Eddy J, Gatewood D, Levis R, Halder M, Pulle G, Kojima H, Casey W, Gaydamaka A, Miller T, Brown K, Lewis C, Chapsal, Bruckner L, Gairola S, Kamphuis E, Rupprecht CE, Wunderli P, McElhinney L, De Mattia F, Gamoh K, Hill R, Reed D, Doelling V, Johnson N, Allen D, Rinckel L, and Jones B. 2012. Report on the International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward. Biologicals. Role of Estrogen Receptor Signaling Required for Endometriosis-like lesion Establishment in mouse July 19, 2012 Burns, KA, Rodriguez, KF, Hewitt, SC, Janardhan, KS, Young, SL, Korach, KS. Role of Estrogen Receptor Signaling Required for Endometriosis-like lesion Establishment in a mouse model. Endocrinology Epub June 14 2012. Proliferative and Non-proliferative Lesions of the Rat and Mouse Central & Peripheral Nervous System July 19, 2012 Kaufmann,W., Bolon, B., Bradley, A., Butt, M., Czasch, S., Garman, R.H., George, C., Groters S., Krinke, G., Little, P., McKay, J., Narama, I., Rao, D., Shibutani, M., and Sills, R.A. (2012) Proliferative and Non-proliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems. Toxicol Pathol.40: 87S-157S. Proceedings of the 2011 National Toxicology Program Satellite Symposium July 19, 2012 Boorman,G., Crabbs, T.A., Kolenda-Roberts, H., Latimer, K., Miller, a.D., Muravnick, K.B., Nyska, A., Ochoa, r., Pardo, I.d., Ramot, Y., Rao, D.B., Schuh, J., Suttie, A., Travlos, G.S., Ward, J.M., Wolf, J.C., and Elmore, S.A. Proceedings of the 2011 National Toxicology Program Satellite Symposium. Toxicol Pathol. 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Genotoxicity of Styrene-Acrylonitrile Trimer in Brain, Liver, and Blood Cells of Weanling F344 Rats June 18, 2012 Hobbs, C.A., Chhabra, R.S., Recio, L., Streicker, M. and Witt, K.L. (2012) Genotoxicity of Styrene-Acrylonitrile Trimer in Brain, Liver, and Blood Cells of Weanling F344 Rats. Environmental and Molecular Mutagenesis 53, 227-238. DOI: 10.1002/em.21680 Assessment of Naphthalene-Induced Genotoxicity & Gluathione Detoxication in Human TK6 Lymphoblasts March 26, 2012 Recio L, Shepard KG, Hernandez, LG, Kedderis GL. 2012. Dose-Response Assessment of Naphthalene-Induced Genotoxicity and Glutahione Detoxication in Human TK6 Lymphoblasts. Toxicol. Sci. 126(2):405-412. Therapeutic Ultrasound as a Potential Male Contraceptive March 23, 2012 Tsuruta JK, Dayton PA, Gallippi CM, O’Rand MG, Streicker MA, Gessner, RC, Gregory TS, Silva E JR, Hamil, KG, Moser GJ, Sokai, DC. 2012. Therapeutic Ultrasound as a Potential Male Contraceptive: Power, Frequency and Temperature Required to Deplete Rat Testes of Meiotic Cells and Epididymides of Sperm Determined Using Commercially Available System. Reproductive Biology and Endocrinology 10:7. 15-Day Intact Male Rat Assay: Evaluation of an Antithyroid Chemical and a Negative Control Chemical March 23, 2012 Becker RA, Bergfelt, DR, Borghoff S, Davis JP, Hamby BT, O’Connor JC, Kaplan AM, Sloan CS, Tyl, RW, Wade M, Marty MS. 2012. Interlaboratory Study Comparison of the 15-Day Intact Adult Male Rat Screening Assay: Evaluation of an Antithyroid Chemical and a Negative Control Chemical. Birth Defects Research (Part B). (95):63-78. Improving Animal Welfare and Reducing Animal Use for Veterinary Vaccine Potency Testing January 23, 2012 Stokes WS, Brown K, Kulpa-Eddy J, Srinivas G, Halder M, Draayer H, Galvin J, Claasen I, Gifford G, Woodland R, Doelling V, Jones B. 2011. Improving Animal Welfare and Reducing Animal Use for Veterinary Vaccine Potency Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):84-105. Alt. Methods to Reduce, Refine & Replace Animal Use for Veterinary Vaccine Post-Licensing Testing January 13, 2012 Kulpa-Eddy J, Srinivas G, Halder M, Brown K, Draayer H, Glavin J, Claassen I, Gifford G, Woodland R, Doelling V, Jones, B, Stokes WS. 2011. Alternative Methods and Strategices to Reduce, Refine and Replace Animal Use for Veterinary Vaccine Post-Licensing Safety Testing: State of the The Science and Future Directions.Procedia in Vaccinology(5):106-119. Alternative Methods to Reduce, Refine & Replace Animal Use for Human Vaccine Post-Licensing Testing January 13, 2012 Isbrucker R, Levis R, Casey W, McFarland R, Schmitt M, Arciniega J, Descamps J, Finn T, Hendriksen C, Horiuchi Y, Keller J, Kojima H, Sesardic D, Stickings P, Johnson NW, Allen D. 2011. Alternative Methods and Strategies to Reduce, Refine and Replace Animal Use for Human Vaccine Post-Licensing Safety Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):47-59. Non-Animal Replacement Methods for Veterinary Vaccine Potency Testing January 13, 2012 Kulp-Eddy J, Srinivas G, Halder M, Hill R, Brown K, Roth J, Draayer H, Galvin G, Woodland R, Doelling V, Jones B, Stokes WS. 2011. Non-Animal Replacement Methods for Veterinary Vaccine Potency Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):60-83. Improving Animal Welfare and Reducing Animal Use for Human Vaccine Potency Testing January 13, 2012 Casey W, Schmitt M, McFarland R, Isbrucker R, Levis R, Arciniega J, Descamps J, Finn T, Hendriksen C, Horluchi Y, Keller, J, Kojima H, Sesardic D, Stickings P, Johnson NW, Lipscomb E, Allen D. 2011. Improving Animal Welfare Reducing Animal Use for Human Vaccine Potency Testing: State of the Science and Future Directions. 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Improvement of In Vivo Genotoxicity: Acute Tests and Integration into Standard Toxicity Testing November 26, 2011 Rothfuss A, Honma M, Czich A, Aardema MJ, Burlinson B, Galloway S, Hamada S, Kirkland D, Heflich RH, Howe J, Nakajima M, O’Donovan M, Plappert-Helbig U, Priestley C, Recio L, Schuler M, Uno Y, and Martus HJ. 2011. Improvement of In Vivo Genotoxicity: Combination of Acute Tests and Integration into Standard Toxicity Testing. Mutat. Res. 723: 108-120. Comet Assay Dose-Response for Ethyl Methanesulfonate Using Freshly Prepared Vs. Cryopreserved Tissue November 26, 2011 Recio L, Kissling GE, Hobbs CA, and Witt KL, 2011. Comparison of Comet Assay Dose-Response for Ethyl Methansulfonate Using Freshly Prepared Versus Cryopreserved Tissues. Environmental and Molecular Mutagenesis (in press). Using Fewer Animals to Identify Chemical Eye Hazards: Criteria to Maintain Hazard Classification October 20, 2011 Haseman JK,Allen DG,Lipscomb EA,Truax JF,Stokes WS. 2011. Using Fewer Animals to Identify Chemical Eye Hazards: Revised Criteria Necessary to Maintain Equivalent Hazard Classification. Regulatory Toxicology and Pharmacology 61:98-104. Disseminiated Histoplasmosis with Concurrent Oral Candidiasis in an Eclectus Parrot October 19, 2011 Quist EM,Belcher C,Levine G,Johnson M,Heatley JJ,Kiupel M, Giri D. 2011. Disseminated Histoplasmosis with Concurrent Oral Candidiasis in an Electus Parrot (Eclectus Roratus). Avian Pathol. 40(3):339. Cerebral and Renal Phaeohyphomycosis in a Dog Infected with Bipolaris Species October 19, 2011 Giri DK,Sims WP,Sura R,Cooper JJ,Gavrilov BK,Mansell J. 2011. Cerebral and Renal Phaeohhyphomycosis in a Dog Infected with Bipolaris Species. Vet Pathol. 48(3):754-7. Neoplastic and Nonneoplastic Liver Lesions Induced by Dimethylnitrosamine in Japanese Medaka Fish October 17, 2011 Hobbie KR,DeAngelo AB,George MH,Law JM. 2011. Neoplastic and Nonneoplastic Liver Lesion Induced by Dimethylnitrosamine in Japanes Medaka Fish. Vet. Pathol. Online. DOI: 10.1177/0300985811409443. Liver Toxicity and Carcinogenicity in f344/n Rats and b6cf1 Mice Exposed to Kava Kava September 22, 2011 Behl M,Nyska A,Chhabra RS,Travlos G,Fomby LM,Sparrow BR,Hejtmancik MR,Chan PC. 2011. Liver Toxicity and Carcinogenicity in f344/n Rats and b6c3f1 Mice Exposed to Kava Kava. Food and Chemical Toxicology. In press for publication in November 2011. Safety Assessment of Allergic Contact Dermatitis Hazards: An Analysis Supporting Reduced Animal Use September 22, 2011 Haseman JK,Strickland J,Allen D,Salicru E,Paris M,Tice RR,Stokes WS. 2011. Safety Assessment of Allergic Contact Dermatitis Hazards: An Analysis Supporting Reduced Animal Use for the Murine Local Lymph Node Assay. Regulatory Toxicology and Pharmacology 59: 191-96. Assessment of a Regulated AAV2 Gene Transfer Vector After Murine Submandibular Glands Delivery September 21, 2011 Zheng C,Voutetakis A,Goldstein B,Afione S,Rivera V,Clackson T,Wenk M,Boyle M,Nyska A,Chiorini J,Vallant M,Irwin R,Baum B. 2011. Assessment of the Safety and Biodistribution of a Regulated AAV2 Gene Transfer Vector After Delivery to Murine Submandibular Glands. Toxicological Sciences. Effects of Atrazine on Steroidgenesis in Rat Granulosa and H295R Adrenal Cortical Carcinoma Cells September 20, 2011 Tinfo NS,Hotchkiss MG,Buckalew AR,Zorrilla LM,Cooper RL,Laws SC. 2011. Understanding the Effects of Atrazine on Steriodogenesis in Rat Granulosa and H295 Adrenal Cortical Carcinoma Cells.Reprod. Toxicol. 31(2):184-93 Histopathological Evaluation of the Nervous System in National Toxicology Program of Rodent Studies September 18, 2011 Rao, D, Little, PB, Malarkey, D.E, Herbert, RA, Sills, RC. 2011. Histopathological Evaluation of the Nervous System in National Toxicology Program of Rodent Studies: A Modified Approach. Toxicologic Pathology 39: 463-470. Genetic Toxicology in the 21st Century: Reflections and Future Directions April 28, 2011 Mahadevan B, Snyder R, Waters M, Benz RD, Kemper RA, Tice RR and Richard AM. 2011. Genetic Toxicology in the 21st Century: Reflections and Future Directions. Environ. Mol. Mutagen. 52. Effects of Hormonally Active Agents on Steroid Hormone Receptor Expression and Cell Proliferation March 16, 2011 Hill GD, Moore AB, Kissling GE, Flagler ND, Ney E, Cline JM, Dixon D. 2011. Effects of Hormonally Active Agents on Steroid Hormone Receptor Expression and Cell Proliferation in the Myometrium of Ovariectomized Macaques. Toxicol. Pathol. 39(3): 508-515. Toxicity Study of Green Tea Extract in Rats and Mice December 1, 2010 Chan PC, Ramot Y, Malarkey DE, Blackshear P, Kissling GE, Travlos G, Nyska A. 2010. Fourteen week Toxicity Study of Green Tea Extract in Rats and Mice. Toxicol. Pathol. 38(7): 1070-1084. Characterizing and Predicting Carcinogenicity and Mode of Action April 24, 2010 Waters M, Jackson MA, and Lea IA. 2010. Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods. Mutat Res 705: 184-200. Dose-Response of Four Genotoxic Chemicals in a Combined Mouse and Rat Micronucleus and Comet Assay April 1, 2010 Recio L, Hobbs CA, Caspary W, Witt KL. 2010. Dose-Response Assessment of Four Genotoxic Chemicals in a Combined Mouse and Rat Micronucleus and Comet Assay Protocol. Toxicol Sciences 35(2): 149-162. No Biomarkers of Genetic Damage or Pathological Changes in Male Rats Administered Ritalin January 1, 2010 Witt KL, Malarkey DE, Hobbs CA, Davis JP, Kissling GE, Caspary W, Travlos G, Recio L. 2010. No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environ Mol Mutagen 51(1): 80-88. Copyright 2018 Integrated Laboratory Systems | All Rights Reserved