ABOUT US PARTNER WITH US THERAPEUTIC AREAS PRODUCTS NEWS/PRESS SHARING CONTACT Inborn errors of Metabolism Inborn errors of primary bile acid synthesis Privacy policy | Term of Use | Code of Conduct Immedica Pharma AB Norrtullsgatan 15 113 29 Stockholm Sweden E-mail: info@immedica.com Phone: +46(0)8 533 39 500 © 2021 All rights Reserved. Design by Immedica

ABOUT US PARTNER WITH US THERAPEUTIC AREAS PRODUCTS NEWS/PRESS SHARING CONTACT Infectious diseases Corneal neovascularisation Privacy policy | Term of Use | Code of Conduct Immedica Pharma AB Norrtullsgatan 15 113 29 Stockholm Sweden E-mail: info@immedica.com Phone: +46(0)8 533 39 500 © 2021 All rights Reserved. Design by Immedica

ABOUT US PARTNER WITH US THERAPEUTIC AREAS PRODUCTS NEWS/PRESS SHARING CONTACT Inborn errors of Metabolism Urea cycle disorders (UCD) Urea cycle disorders (UCD) The urea cycle is a process in which waste (ammonia) is removed from the body. When you eat proteins, the body breaks them down into amino acids. Ammonia is produced from leftover amino acids, and it must be removed from the body. The liver produces several chemicals (enzymes) that change ammonia into a form called urea, which the body can remove in the urine. If this process is disturbed, ammonia levels begin to rise. Several inherited conditions can cause problems with this waste-removal process. People with a urea cycle disorder are missing a gene that makes the enzymes needed to break down ammonia in the body. These diseases include: Argininosuccinic aciduria Arginase deficiency Carbamyl phosphate synthetase (CPS) deficiency Citrullinemia N-acetyl glutamate synthetase (NAGS) deficiency Ornithine transcarbamylase (OTC) deficiency As a group, these disorders occur in 1 in 30,000 newborns. OTC deficiency is the most common of these disorders. Read more in our broschure on Urea Cycle Disorder Click here Privacy policy | Term of Use | Code of Conduct Immedica Pharma AB Norrtullsgatan 15 113 29 Stockholm Sweden E-mail: info@immedica.com Phone: +46(0)8 533 39 500 © 2021 All rights Reserved. Design by Immedica

ABOUT US PARTNER WITH US THERAPEUTIC AREAS PRODUCTS NEWS/PRESS SHARING CONTACT Inborn errors of Metabolism distal Renal Tubular Acidosis (dRTA) distal Renal Tubular Acidosis (dRTA) Distal renal tubular acidosis (dRTA) is a disease that occurs when the kidneys do not properly remove acids from the blood into the urine. As a result, too much acids remain in the blood which generates an unbalanced pH in the blood. The inability to remove acids from the body often results in failure to thrive. It may also, as a result of the body’s attempt to buffer the acid blood with molecules from the bone, lead to softening and weakening of the bones, called rickets in children and osteomalacia in adults. Privacy policy | Term of Use | Code of Conduct Immedica Pharma AB Norrtullsgatan 15 113 29 Stockholm Sweden E-mail: info@immedica.com Phone: +46(0)8 533 39 500 © 2021 All rights Reserved. Design by Immedica