STRATEGY Play to Win > Download the Play to Win investor presentation Facebook Twitter LinkedIn Sanofi CEO Paul Hudson unveiled new strategy to drive innovation and growth at Sanofi's Capital Markets Day on December 10, 2019. Prioritize key growth drivers – Dupixent® (dupilumab) and vaccines Accelerate R&D focus on six potentially transformative medicines Improve operating efficiencies to fund growth and expand business operating income margin1 Align to support new strategy with three core businesses and a standalone Consumer Healthcare unit “Our new strategy positions Sanofi to achieve breakthroughs with our most promising medicines, addressing significant patient needs. We will anchor our efforts in leading-edge science with clearer priorities and a focus on delivering results,”said Hudson. “Sanofi gained leadership and changed the practice of medicine in diabetes and cardiovascular diseases. We are now preparing for our next cycle, with a new round of innovative solutions for patients. I’m confident we will achieve long-term growth and value for shareholders while turning innovation into transformative medicines for patients.” More information about the Capital Markets Day Focus on growth Dupixent® (dupilumab)2 – Sanofi expects to deliver strong growth for Dupixent with the ambition of achieving more than €10 billion in peak sales driven by its unique mechanism of action targeting the type 2 inflammation pathway. Vaccines – Vaccines are expected to deliver a mid-to-high single-digit net sales CAGR from 2018 to 2025, through differentiated products, market expansion and new launches. Pipeline – The company has identified and prioritized six potentially transformative therapies. Additional core drivers include treatments for oncology, hematology, rare diseases, neurology, and Sanofi’s strong presence in China. Lead with innovation Sanofi has six potentially practice changing therapies in areas of high unmet patient need. These investigational therapies are listed as follows in order of planned submission timing: Fitusiran is an RNAi therapeutic in development for the treatment of hemophilia A and B with or without inhibitors with the potential to provide once-monthly dosing convenience. BIVV0013 is a factor VIII therapy designed to extend protection from bleeds with prophylaxis dosing of once weekly for people with hemophilia A that seek to enjoy a normalized lifestyle. Venglustat is an oral therapy in development for several rare diseases in the category of lysosomal storage disorders (Gaucher type 3, Fabry, Tay-Sachs disease, etc.), and also showing promise for more common disorders including autosomal dominant polycystic kidney disease and some sub-types of Parkinson’s disease. SERD (‘859) is a selective estrogen receptor degrader which aims to be the new standard of care in hormone-receptor-positive breast cancer. Nirsevimab4 is a potentially cost-effective prevention against respiratory syncytial virus, with initial focus on protecting infants. BTKi (‘168)5 is an oral medicine for multiple sclerosis with potential to be the first disease-modifying therapy to address inflammation and disability drivers in the brain. The company also announced plans to acquire Synthorx, Inc. which will bolster its immuno-oncology (IO) pipeline with both a proprietary IO platform synergistic with Sanofi’s existing therapeutics platforms, and a lead IO candidate (THOR-707) being explored across multiple solid tumor types both alone and in combination with immune checkpoint inhibitors and other future IO combinations. Additional details can be found here: https://www.sanofi.com/en/media-room/press-releases/2019/2019-12-09-07-00-00 Sanofi plans to hold a R&D Day in 2020 to provide a detailed review of its R&D portfolio of candidate medicines, strategy, and specifically productivity. Accelerate efficiency Sanofi expects to expand its business operating income (BOI) margin1 to 30% by 2022, with an ambition for its BOI margin to exceed 32% by 2025. The company is also announcing efficiency initiatives that are expected to generate €2 billion savings by 2022. These savings will fund investment in its key growth drivers and accelerate priority pipeline projects as well as support the expansion of the BOI margin. The efficiency savings are expected to result primarily from limiting spend on de-prioritized businesses, from smart spending (procurement) initiatives and from operational excellence in manufacturing and organizational productivity. Regarding de-prioritized businesses, Sanofi is announcing a discontinuation of research in diabetes and cardiovascular (DCV) and will not pursue plans to launch efpeglenatide6. The company will also optimize the commercial model for DCV and rheumatoid arthritis, including right-sizing the resources deployed behind Praluent® (alirocumab)2 and Kevzara® (sarilumab)2. Reinventing how we work Sanofi will be structured with three core global business units to support the company’s strategy7 – Specialty Care (immunology, rare diseases, rare blood disorders, neurology and oncology), Vaccines, and General Medicines (diabetes, cardiovascular, and established products). Consumer Healthcare will be a standalone business unit with integrated R&D and manufacturing functions. Hudson explained, “Our objective for the Consumer Healthcare business is to unlock value and entrepreneurial energy by growing faster than the market over the mid term. We believe the new standalone structure, coupled with plans to accelerate the over-the-counter switches for Cialis® and Tamiflu®, will position the business well to accomplish this ambition.” 1 See Appendix 3 for definition 2 Partnered with Regeneron 3 Partnered with SOBI 4 Partnered with AstraZeneca 5 Partnered with Principia 6 Sanofi commits to complete ongoing studies – Sanofi will look for a partner to take over and commercialize efpeglenatide 7 Subject to completion of the appropriate social processes Read the press release and access to the appendices Follow us Sanofi on Twitter Sanofi TV on YouTube Sanofi On LinkedIn Sanofi on Instagram Sanofi RSS feeds Contact Legal notice Privacy & Data Protection Cookies policy Corporate code of ethics Our publications Sitemap Our websites Accessibility: partial compliance © Sanofi 2004-2021 - All rights reserved