Learn more OK Products Knowledge center Applications Service and support News and events ICMS About us PIONEERING ION CHANNELS NEWS Society for Neuroscience posters on large molecule drug discovery & stem cell (hiPSC) derived neuron recordings using automated patch clamp Again this year, there is plenty of interesting content at SfN for Ion Channel aficionados. Check out these three virtual poster presentations on large molecule drug discovery and stem cell characterization. NEWS Large molecules and automated patch clamp: A case study of Scorpion toxin block of BK channels on Qube 384 Pharmacological characterization of charybdotoxin evaluated on Qube in fluoride-free solutions HIGHLIGHTS Tricky CRAC channels not so tricky on Qube and QPatch ICRAC recordings have been considered 'tricky' on Automated Patch Clamp (APC) due to not being able to use high calcium and fluoride needed in ’seal enhancing’ solutions on some APCs. But not if you use Qube 384 or QPatch HIGHLIGHTS TRP channels, Nobel prizes and Automated Patch Clamp In honour of this year’s Nobel price laureates and for those of you that would like to learn more about TRP channels, we have gathered some TRP-themed ICMS videos, peer-reviewed publications, application reports and posters NEWS Linköping University epilepsy research accelerated by QPatch II “[QPatch II] enables us to carry out experiments around 48 times more rapidly. Work that normally takes a year can be completed in approximately a week ... it will enable us to open up new territory” HIGHLIGHTS Sophion Academy - how-to video tutorials Learn how to clean the bed of nails on your QPatch - from the comfort of your sofa or in front of your screen at your office. Sophion Academy offer a broad range of online tutorials; made just for you to make your work-life life easier NEWS iPSC cardiomyocyte recordings on QPatch II with success rates of up to 50% In collaboration with the University of Göttingen generated QPatch II recordings of cardiomyocytes with a fantastic result NEWS Sophion, DTU, Universidad Costa Rica & IONTAS collaboration on breakthrough antivenom paper Discovery and development of a monoclonal antibody to neutralize Cobra venom HIGHLIGHTS Ion Channels and Cancer Transport of ions across the cell membranes play a critical role in tumour cell functions, such as cell volume regulation, cell migration, cell cycle progression, cell proliferation and cell death. Functions that are critical for tumour cell survival as well as metastasis. NEWS Sophion PNAS paper on nanomaterials & the blood brain barrier In a Marie Curie funded collaboration with the University of Birmingham, UK, Sandra Wilson has co-authored a paper on the potential effects of nanomaterials crossing the blood brain barrier NEWS Ion channel talks for graduate and undergraduate students Daniel Sauter recently gave a talk on ‘Ion Channel Drug Discovery’ at Universidad De La Salle Bajio, Mexico. Watch the recording on Facebook or contact us if you would like us to do similar educational talks at your institution. HIGHLIGHTS Interested in Optogenetics? Learn more about this powerful technique and browse through some of our publications to get inspired on how this technology might benefit your research Sophion partners with Genedata, the leading provider of enterprise software solutions for biopharmaceutical R&D, to enable standardized integration between Sophion APC platforms and Genedata Screener. Read more here: 6 - 9 February — Event SLAS2022 Meet our ion channels experts at SLAS in Boston 20 - 23 February — Event Biophysics 2022 We’ll be at BPS2022 in San Francisco in February 2022 DISEASE AREAS Pain Ion channels are involved in both initiating and transmitting pain Cardiovascular Ion channels are key in drug safety studies and important target for many heart diseases CNS Evidence suggest that ion channels play a key role in psychiatric diseases Cancer Ion channels play an emerging role as potential drugable targets for cancer treatments Other Read more about other disease areas driven by ion channel malfunction Sophion Bioscience A/S Tel: +45 44 60 88 00 Email: info@sophion.com Follow us: LinkedInTwitter Certification CiPA ISO 9001