Created with Sketch. Home News Bioprinting Bioprinters Bioink Investor Relations Contact Support Store Information See our inks Bioink by CELLINK The future of Bioprinting At CELLINK we have a passion to develop new bioinks with good printability and bioactive properties that guide cellular fate processes. Our goal is to support tissue engineers, cell biologist and clinicians to help translate innovative 3D bioprinting technology and bioinks into the clinic. Get a quote See our inks Bioink 3D Bioprinting of human tissues and organs is revolutionizing the field of tissue engineering and thus, the future of medicine. We believe we can create this future through a collaborative spirit with scientist all over the world and by putting our combined expertise to the service of humanity. What is a bioink? A bioink is a hydrogel biomaterial that is suitable for bioprinting with mammalian cells and it provides a temporary support to the cells while they produce their own extracellular matrix [1]. Bioinks based on biopolymers, such as collagen, gelatin, hyaluronan, silk, alginate, and nanocellulose, are known for their favorable biocompatible properties and are attractive biomaterials for cell encapsulation and 3D bioprinting. These bioinks provide an aqueous 3D environment with biologically relevant chemical and physical signals, mimicking the natural extracellular matrix environment. Significant advances in 3D bioprinting technology as well as development of new bioinks have made it possible to bioprint complex 3D tissue structures [2, 3]. CELLINK’s bioink… provide mammalian cells with a milieu that resembles their natural matrix while their printability makes it possible to bioprint complex, cell-laden constructs. When you are looking for an ideal solution to all your 3D Bioprinting and 3D cell culturing needs you can count on CELLINK to deliver the results you are looking for. CELLINK provides sterile and ready-to-use bioinks in 3mL and 10mL cartridges, adapting to your bioprinting needs. Bioink and it’s properties Ideally, the bioink should exhibit a high zero-shear viscosity, shear-thinning behavior and rapid gelation in order to maintain a high shape fidelity during the bioprinting process. In addition to having good printability, the bioink should also provide a biologically relevant 3D environment that supports cell fate processes, such as cell attachment, proliferation and differentiation. [1] Malda J, Visser J, Melchels FP, Jungst T, Hennink WE, Dhert WJ, et al. 25th anniversary article: Engineering hydrogels for biofabrication. Advanced Materials. 2013;25:5011-28. [2] Kolesky DB, Homan KA, Skylar-Scott MA, and Lewis JA. Three-dimensional bioprinting of thick vascularized tissues. PNAS. 2016. [3] Martinez Avila H, Schwarz S, Rotter N and Gatenholm P. 3D bioprinting of human chondrocyte-laden nanocellulose hydrogel for patient-specific auricular cartilage regeneration. Bioprinting. 2016. Application of Bioinks The future of Bioprinting CELLINK is the first universal bioink that has been optimized for 3D bioprinting of human tissue. When you are looking for an ideal solution to all your 3D bioprinting needs you can count on CELLINK to deliver the results you are looking for. Application Cartilage Skin Bone Muscle MSCs Sacrificial material CELLINK CELLINK RGD CELLINK Bone CELLINK A CELLINK A-RGD CELLINK CollMaGel CELLINK GelMa CELLINK PCL CELLINK Pluronics CELLINK Start CELLINK Bioink CELLINK Bioink is the first universal bioink optimized for 3D bioprinting of human tissue models with any commercially available and in-house developed 3D bioprinting system. As a polysaccharide hydrogel (non-animal derived), CELLINK is ideal for 3D bioprinting and cell culturing. The biologically relevant 3D environment of CELLINK Bioink, composed of alginate and highly hydrated cellulose nanofibrils with morphological similarity to collagen, provides mammalian cells with a milieu that resembles their natural matrix; while the excellent printability of this bioink make it possible to bioprint complex, cell-laden tissue constructs such as a human auricle. The unique biocompatibility and printability of CELLINK Bioink offers outstanding results that will take your research to the next level! CELLINK bioink can be mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process. CELLINK bioink is simply cross-linked with our ionic binding agent after the bioprinting process. See recent publication Publications Buy Now CELLINK RGD CELLINK RGD bioink offers the same good printability properties and biologically relevant 3D environment as CELLINK bioink with an additional biofunctionalization of RGD motifs to improve cell attachment. CELLINK RGD bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process. CELLINK RGD bioink is simply cross-linked with our ionic binding agent after the bioprinting process. Buy Now CELLINK Bone CELLINK BONE bioink offers the same good printability properties and biologically relevant 3D environment as CELLINK bioink with an additional biofunctionalization of synthetic, osteoconductive particles for bone tissue engineering applications. This bioink is composed of two of the main constituents of bone, calcium and phosphorous. CELLINK BONE bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process. CELLINK BONE bioink is simply cross-linked with our ionic binding agent after the bioprinting process. Buy Now CELLINK A CELLINK A is a biodegradable bioink specifically developed for advanced 3D Bioprinting researchers. CELLINK A offers excellent biocompatibility, easy handling, and works with a wide range of human cells. CELLINK A is composed of highly purified sodium alginate and crosslinks with divalent cations. This is a widely used biomaterial known to be inert and biocompatible. CELLINK A bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process. As with our other bioinks, CELLINK A is simply cross-linked with our ionic binding agent. You can utilize any of our sacrificial bioinks such as CELLINK Support and CELLINK Start when bioprinting with CELLINK A to create porous structures. Buy Now CELLINK A-RGD CELLINK A-RGD bioink offers the same 3D environment as CELLINK A bioink with an additional biofunctionalization of RGD motifs to improve cell attachment. CELLINK A-RGD bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process. CELLINK A-RGD bioink is simply cross-linked with our ionic binding agent. You can utilize any of our sacrificial bioinks such as CELLINK Support and CELLINK Start when bioprinting with CELLINK A-RGD to create porous structures. Buy Now CELLINK CollMaGel CELLINK CollMaGel is a type I collagen-based bioink that provides mammalian cells with a milieu close to their native environment. The naturally derived collagen I is modified with methacryloyl substitution groups, which crosslink with the assistance of a photoinitiator (eg. Irgacure 2959) and exposure to UV light. CELLINK CollMaGel bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process. Buy Now CELLINK GelMa CELLINK GelMa is a gelatin-based bioink that provides mammalian cells with a milieu that resembles some essential properties of their native environment. GelMA bioink is modified with methacryloyl substitution groups, which crosslink in the presence of a photoinitiator (eg. Irgacure 2959) and exposure to UV light (eg. INKREDIBLE UV Curing System), yielding a stable gel. Prior to bioprinting, CELLINK GelMa bioink can mixed with high concentration of cells with our CELLMIXER for a one-step bioprinting process. Publications Buy Now CELLINK PCL CELLINK PCL is a high molecular weight (Mn 50,000) thermoplastic linear polyester derived from caprolactone monomer. This biodegradable polyester has a melting point of 60°C. CELLINK PCL can be used as a support to provide a re-enforcing structure when bioprinting load-bearing tissue constructs, such as bone grafts or osteochondral plugs, for in vitro and in vivo studies. It can also be used as a support material to provide a temporary scaffold for overhanging structures during 3D bioprinting. Supplied in granular form (3 mm pellets). Buy Now CELLINK Pluronic® F-127 CELLINK Pluronic® F127 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol. This copolymer is widely used as a sacrificial material when bioprinting cell-laden constructs with bioinks having poor shape fidelity. CELLINK Pluronic® F127 is printed at room temperature and easily dissolves when cooled, making it an easy to use sacrificial material. Buy Now CELLINK Start CELLINK Start is a water soluble gel used as a sacrificial material when bioprinting cell-laden constructs with bioinks having poor shape fidelity or to prevent sagging of bioink filament and thus, bioprint constructs with porosity along all three axis. CELLINK Start is printed at room temperature and easily dissolves when washing with culture media after gelation of cell-laden bioink – making it an easy to use sacrificial material. 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