Organix has been involved in lipid synthesis since Organix was founded in 1986. During this time we have been involved in proprietary synthesis of novel lipids as well as synthesis of standards from the published literature. PRICING MODELS LIPIDS/LIPOIDS FOR mRNA DELIVERY HIT TO LEAD AND SAR STUDIES POLYMER CONJUGATES, BIOCONJUGATES, & OLIGONUCLEOTIDES NATURAL PRODUCTS MICROSPHERE SYNTHESIS & MICROENCAPSULATION CONTROLLED SUBSTANCES LIPIDS/LIPOIDS FOR mRNA DELIVERY WE HAVE IN-DEPTH EXPERIENCE IN: Synthesis of Lipids Purification and handling of Lipids Analysis of Lipids Organix understands purity is of utmost importance when it comes to lipids for drug delivery and nano-particle formation. Therefore our lipids are of the highest purity and we use only the most reputable of suppliers for our starting materials in any of our lipid/lipoid synthesis. HIT TO LEAD AND SAR STUDIES WE PROVIDE QUALITY SERVICES IN: Hit-to-Lead Studies Lead Generation and Optimization Structure Activity Relationship (SAR) Studies to discover new molecular entities and optimize lead compounds Design, Evaluation and Optimization of Synthetic Procedures Design and Synthesis of New Molecular Entities. POLYMER CONJUGATES, BIOCONJUGATES, & OLIGONUCLEOTIDES HRP CONJUGATES Organix designs and synthesizes small molecules containing selected linkers for attachment to HRP. These conjugates are purified (TFF) and characterized (NMR & HPLC-UV/HPLC-ELSD). These conjugates incorporate derivatives of steroids (e.g.progesterone, cortisol, estradiol) and indole analogs (e.g.melatonin). Organix synthesizes polymer conjugates containing stable isotope labels. Loading ratios are determined. (Annal. Chem. 2002, 74, 4969) THIOL REACTIVE CONJUGATES Organix prepares PEG-dye polymer conjugates. These are purified (TFF and C18-RP chromatography) and characterized (NMR & HPLC) (Nature Biotech 2008, 26(2), 235) Organix designs and synthesizes PEG–vitamin derivatives. Linked compounds are regio-selectively attached to bifunctional PEG compounds. Conjugates are purified (HPLC) and characterized (NMR). Conjugates are linked to proteins and antibodies. PEG CONJUGATES Organix prepares HPMA polymer conjugates (RAFT polymerization / living polymers.) Conjugates are purified (TFF and C18-RP chromatography) and characterized (NMR) and analyzed (HPLC/GPC). HPMA CONJUGATES Organix has coupled small molecules and lipids to GalNAc. Purification (reverse phase chromatography) and characterization (NMR) on these conjugates (MW >1,500-4,000) is conducted. GALNAC CONJUGATES Organix conducts phosphitylation. These building blocks are synthesized, purified and characterized (NMR & HPLC-UV/HPLC-ELSD). PHOSPHITYLATION NATURAL PRODUCTS Organix has considerable experience in the extraction/isolation/identification of compounds from Natural Resources. The following selection of case studies exemplify our experience. CASE STUDY #1: BIOLOGICAL ACTIVE WAS UNKNOWN FROM PLANT LEAVES. In this case the client came to Organix with biological results of a natural product derived from plant leaves. The structure of the active compound was unknown and the occurrence (% of active/biomass) was also undetermined. Organix was provided 1 kg of leaves which we processed by first converting to a fine powder (blender) and then we subjected the powder to extraction with various solvents of different polarity. We also treated the powder with water: basic, neutral and acidic. Each of the fractions were then sent to the client for biological testing and then the active was followed until chromatography was needed and eventually, we ended up with pure material. This organic pure material was the active component and we were able to identify the material by MS and 2D NMR. A literature search eventually led to us finding a publication of the exact compound that had been synthesized a year earlier by a well-known professor. CASE STUDY #2: BIOLOGICAL ACTIVE WAS KNOWN AND AN ISOLATION PROTOCOL REQUESTED. In this case the client already knew the active compound and the plant genus and we obtained different plants from different regions of the country/globe and investigated the occurrence of the active in different parts of the plant. We then went on to develop a high yielding method of extraction and isolation of the active and confirmed the identity by LCMS & NMR as compared with an authentic sample. CASE STUDY #3: SAR PROGRAM FROM A NATURAL PRODUCT EXTRACTED FROM AN OIL. In this case the client provided a large amount of oil that contained an enriched mixture of four related natural products. Organix conducted a multiyear multiple FTE program where we isolated the natural products and made analogs of the four classes and sent them for biological testing. This was a long-term project with a major pharmaceutical company with weekly meetings. Our SAR was directed by the biological results and derivatives were synthesized in order to enhance the physical properties of the compounds as well as increase their efficacy and biological activity. MICROSPHERE SYNTHESIS & MICROENCAPSULATION Organix has considerable experience with the microencapsulation of a variety of drugs. Our expertise includes the preparation of gels and other inert polymeric coatings for chemotherapeutic agents, opioids for pain management, and other pharmaceutical agents where controlled release via biodegradation is desired. We optimize experimental conditions to vary the size and loading of the microspheres obtained and carry out time release studies at ambient and elevated temperatures. Stability studies and evaluation of drug half lives are conducted. CONTROLLED SUBSTANCES Organix is licensed by the Drug Enforcement Agency to conduct research and manufacture of controlled substances and their derivatives or analogs in Schedules 1 through 4. We offer reference standards in the following areas and we also have extensive research experience in these specialized templates. VIEW OPIOID PRODUCTS VIEW TROPANE PRODUCTS VIEW TRYPTAMINE PRODUCTS DO YOU HAVE A QUESTION ABOUT ANY OF OUR MEDICINAL CHEMISTRY SERVICES? CONTACT US, OR REQUEST A QUOTE USING THE FORM BELOW. Name * First Name Last Name Email Address * Message * ORGANIX 240 Salem Street Woburn, MA 01801 email: organix@organixinc.com phone: 781-932-4142 We use cookies to provide you with a great experience and to help our website run effectively. By using this website, you agree to our use of cookies.