Contact LinkedIn Twitter Home About Technology Pipeline Patients News & Media Investors Join Our Crew CABA™ Platform Posters & Publications Posters & Publications Chimeric autoantibody receptor (CAAR) T cells as a precision therapy for antigen-specific B cell depletion in PLA2R membranous nephropathy ASN Kidney Week 2021 | November 5, 2021 2021 ASN Kidney Week Virtual Presentation Antigen-specific B-cell depletion for precision therapy of mucosal pemphigus vulgaris The Journal of Clinical Investigation | August 20, 2020 Desmoglein 3 chimeric autoantibody receptor T cells (DSG3-CAART) expressing the pemphigus vulgaris (PV) autoantigen DSG3 fused to CD137-CD3ζ signaling domains, represent a precision cellular immunotherapy approach for antigen-specific B cell depletion. Here, we present definitive preclinical studies enabling a first-in-human trial of DSG3-CAART for mucosal PV. DSG3-CAART specifically lysed human anti-DSG3 B cells from PV patients and demonstrated activity consistent with a threshold dose in vivo, resulting in decreased target cell burden, decreased serum and tissue-bound autoantibodies, and increased DSG3-CAART engraftment. View Publication MuSK chimeric autoantibody receptor (CAAR) T cells for antigen-specific cellular immunotherapy of myasthenia gravis AAN 2020 Abstract 2769 | May 18, 2020 2020 AAN Virtual Presentation View PDF version Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease Science | July 8, 2016 Autoimmune diseases such as lupus and rheumatoid arthritis lack therapies that specifically target only the disease-causing cells. Inspired by the clinical success of using chimeric antigen receptor T cells to treat certain types of cancers, Ellebrecht et al. asked whether a similar approach might also work against antibody-driven autoimmune diseases. View Publication About Technology Pipeline Patients News & Media Investors Join Our Crew 2929 Arch Street Suite 600 Philadelphia, PA 19104 © 2021 Cabaletta Bio, Inc. All Rights Reserved. Privacy Policy Disclaimer Terms of Use Sitemap