HOME News and Events Download Sterile filling Non sterile filling Contacts Sterile Filling VIALS AMPOULES CARTDRIDGES SYRINGES COMBINED FILLING - VIALS AND SYRINGES - VIALS AND AMPOULES - VIALS AND CARTDRIDGES - VIALS AND SYRINGES AND CARTDRIDGES NEST SYRINGES OPHTALMIC Different filling systems available, i.e. Volumetric Pumps Integrated 100% IPC in line check weighing Different stoppering station applications, i.e. pick and place Possibility of independent capping machine Tray loader system for freeze dryer loading Bungs insertion station for PFS Sterile Filling Aseptic processing in particular is regulated by GMP and FDA guidelines as well as other directives which provide the foundation for the concept and design of our production systems. VIALS SFM vials filling machines type VFM handle from 2ml to 100ml vials with minimal format changes and with production speeds up to 400 vial/min, according to vial size and filling volume. The filling machines are equipped with an in-feed rotating table which feeds empty vials into the walking beam system. The pumps in the filling section fill the correct volume into the vials. Filling operations are carried out in two steps by means of stainless steel dosing nozzles mounted on an AISI316L stainless steel support. To avoid foaming, the filling system utilizes diving nozzles that, during the filling operation, is retracted upward. Each vial can be individually weighed before and after filling to get the net fill weight. A feedback control loop can also be provided to automatically adjust the filling volume of each individual filling pump. For high speed filling machines, a statistical check weighing system is foreseen. Vials proceed to the stopper inserting station where stoppers are fed by a vibratory feeder bowl to the stoppering unit. VFM50 - Up to 3.000/hour VFM100 - Up to 6.000/hour VFM200 - Up to 12.000/hour VFM300 - Up to 18.000/hour VFM400 - Up to 24.000/hour AMPOULES SFM ampoules filling and sealing machine is a linear filler suitable to process 4, 6 or 8 ampoules at each machine cycle, according to the required output. The machine has been designed following the criteria typically needed in aseptic environments, such as, reduced dimensions, geometry facilitating the unidirectional airflow, high ergonomic level, slim design. The very accurate constructive concepts allow the machine to condition ampoules at high speed: up to 400 ampoules/min and the possibility to handle both open and closed ampoules. A "combi" version is also available to match ampoules and vials filling. The filling of ampoules is carried out by means of volumetric pumps even if the machine can be equipped with other filling systems typical of aseptic operations as Time/Pressure or Peristaltic Pumps. The sealing station consists of two stations with different burning temperatures (according to the ampoules glass thickness). The machine is equipped with the gas shut off system in case the flames failure. AFM200 - Up to 12.000/hour AFM300 - Up to 18.000/hour AFM400 - Up to 24.000/hour CARTDRIDGES The design of the SFM KFM series complies with the GMP and US FDA regulations. This machine performs the following operations: Cartridge infeed to the working area through an infeed star-wheel. Lower positioning of the bung. Introduction of mixing balls. Gas flushing before filling process. Filling. Closing of the cartridge with an aluminum cap and rubber stopper. Accumulation of the cartridge to the next machine or operation. As all other SFM machines also the KFM type is equipped with servo motor drives. The filling is done in two steps to avoid introduction of air in the cartridge. The filling can be performed either with volumetric- or peristaltic pumps. The closing station is equipped with a crimp head, which achieves a minimum generation of particles during the closing process. The changeover to a different size can be carried out quickly, easily and without tools, by exchanging complete sets of size parts. KFM50 - Up to 3.000/hour KFM100 - Up to 6.000/hour KFM200 - Up to 12.000/hour SYRINGES SFM filling machines SYFM series performs Pre Filled Syringes (PFS) from 1ml to 20ml, with minimal format changes, and with production speed up to 200 PFS/min. The walking beam transports the PFS through the pre-gas station, the filling station and the post-gas station. In the bung insertion station the star-wheel handles bung stoppers fed by a vibratory feeder bowl and special double pistons insert the bung stoppers into the PFS. Incomplete syringes, without bung stopper, will be automatically rejected. SYFM50 - Up to 3.000/hour SYFM100 - Up to 6.000/hour SYFM200 - Up to 12.000/hour COMBINED FILLING Thanks to the GMP conform modular design of SFM machines certain filling and closing stations can be arranged in one single machine platform. This advanced design enables SFM to combine i.e. Ampoule and Vial filling in one common base machine in order to customize the process. Combined filling machines perform: VIALS AND SYRINGES VSFM VIALS AND AMPOULES VAFM VIALS AND CARTDRIDGES VKFM VIALS AND SYRINGES AND CARTDRIDGES VSKFM NEST SYRINGE The SFM NFM series is a filling and stoppering machine for ready-to use, disposable syringes in nests. The filled and stoppered syringes in the nests are automatically re-inserted into the tubs to be taken to the next step in the secondary packaging process. The machine can be equipped with volumetric pumps or with other filling systems typical of aseptic operations as Time/Pressure or Peristaltic Pumps. CIP/SIP system is available on request. The NFM series is fully equipped with brushless motors to reach maximum flexibility in handling and filling accuracy. NFM 100 NFM 200 OPHTALMIC The SFM OFM series is an intermittent motion filling and closing machine with a wide performance range. It is suitable for dosing volumes from 0.25 ml to 100 ml with a speed of up to 200 bottles/min. The machine is supplied with different dosing systems (volumetric pumps with gravity valves, front or rotating valves, 2 or 3 piece cylinder valves, time/pressure filling system and peristaltic pumps) and a large number of closures can be applied, too. The OFM is used to pack pharmaceutical products, from syrups to oral and nasal drops. No bottle/no fill device is available, as well as filling needles with pneumatic cut-off system, capping pressure control, screw-capping with torque control. The machine is built in AISI 304 or AISI 316L and fully cGMP compliant. OFM 50 - Up to 3.000/hour OFM100 - Up to 6.000/hour OFM200 - Up to 12.000/hour HOME | News | Sterile filling | Non sterile filling | Contacts SFM S.r.l. - VAT No. IT 05736290965 - Company info