Products Documents Pharma and Nutraceuticals Oral dosage Solubility and Stability Print: Solubility and stability improvement We offer a full range range of solubilization and stability enhancers: native and hydroxypropyl cyclodextrins KLEPTOSE®, and octenyl succinate starches CLEARGUM® CO, for use in many dosage forms, from solid to liquid. Native betacyclodextrins Molecular inclusion complexes using cyclodextrins have become an common formulation strategy to improve the solubility or stability of active ingredients. Roquette has pioneered the development of betacyclodextrin technology, developing a full range of KLEPTOSE® betacyclodextrins. With different powder properties, chemical substitutions and solubility profiles, they are able to meet modern formulation needs. Octenyl succinate starches CLEARGUM® CO are amphiphilic polymers providing multiple functions: Decreases surface tension for the stability of your emulsions (liquid or solid) Increases wettability of your API and speed of dissolution Improves directly API solubility in water via its stabilization Hydroxypropyl betacyclodextrins Push back your formulation limits with our hydroxypropyl betacyclodextrins enabling technology: KLEPTOSE® HPB, HP and KLEPTOSE® PB-LB. For a long time, hydroxypropyl betacyclodextrins technology has been used exclusively by a select few. Today, the patent environment for HPBCD is more favourable for new formulations and the use of HPBCD technology in pharmaceuticals is now free of any broad-use restrictions except within the sole US territory till 2019. You no longer have to let a poorly soluble active ingredients limit your formulation power! Discover more about our excipients and active ingredients Product catalogue Product finder Resources Nutraceuticals & OTC Solutions An unwavering commitment to enabling health supporting nutraceuticals and OTC consumer products. Related resources : Pharma - Nutraceuticals and OTC Solubility improvement solutions Don’t let poor bioavailability hold you back. Advance your oral dosage forms with our versatile solubilizing solutions. Related resources : Pharma - Oral dosage - Solubility Stability Brochure : Oral dosage overview When it comes to meeting the challenges of formulation, you need more than just an ingredient supplier. Related resources : Pharma - Oral dosage forms More resources More details on our selected solutions Roquette BioPharma solutions Quality-based, safe, secure, and reliable supply of raw materials and excipients for biologics. Pyrogen-free solutions for life-saving injectables Pyrogen-free pure materials for parenteral preparations. Direct compression: cost-effective solutions to optimise your formulations Expertise from lab to pilot to industrial scale and a large range of high-quality excipients to reduce time-to-market. Disintegrants and superdisintegrants solutions A range of sodium starch glycolates (GLYCOLYS® and EXPLOSOL®) and more than 30 years experience in the field to help in your formulations development. Excipients for solubility and stability improvement & taste masking. KLEPTOSE® betacyclodextrins range to improve the solubility or stability of active ingredients, or to improve the palatability of drugs. Coating solutions A natural inert polymer (LYCOAT®) and a ready-to-use coating system (ReadiLYCOAT®) for fast aqueous film coating that saves up to 50% or more time. Other solutions Coating Use a film coating to mask unpleasant odors and tastes, and protect drugs from environmental factors. A benefit for both patient and laboratory. Fillers, Diluents and Binders Discover the variety of fillers, diluents and binders Roquette offers for the formulation of your solid dosage forms. Taste-masking Discover our full range of KLEPTOSE®, efficient taste-masking agents adapted to all process and formulation constraints you might have. Disintegrants and Superdisintegrants Roquette's wide range of disintegration excipients facilitate the dissolution or release of the active ingredients of your capsules or tablets. Liquid solutions Roquette offers a large range of plant-based excipients for the formulation of liquid forms: syrups, solutions, ampoules, dispersions, etc. Learn more about our solutions? Your success is our greatest priority, and your needs are unique. We would love to better understand your needs and connect you with our experts. Get more information Need more information about this solution? Get more information Contact Us Careers Our suppliers Our Locations Sitemap Useful Links FAQ Follow us on Legal Notice Data Protection General conditions of sales Cookie Policy California Transparency Ethics and Compliance © 2016-2021 Roquette Frères. All rights reserved. By clicking “Accept All Cookies”, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Our cookie policy Accept All Cookies Reject All Cookies Settings