The kSORT® Assay by Immucor kSORT is a non-invasive gene expression assay that enables enhanced post-transplant surveillance and monitors immune quiescence for transplant patients. Join the (R)Evolution of non-invasive post transplant surveillance by using the latest gene expression assay to rule out sub clinical or clinical rejection. MESSAGE A SPECIALIST DOWNLOADS kSORT IN THE NEWS Palmetto GBA Finalizes Local Coverage Determination (LCD) for Liquid Biopsies for Solid Organ Transplantation, Including Immucor’s kSORT Assay VIEW PRESS RELEASE UPCOMING EVENT ATC 2021 Virtual Connect WHEN June 4-9, 2021 WHERE atcmeeting.org REGISTER HERE PARTNERS kSORT Benefits The Need for a Non-Invasive Alternative to Surveillance Biopsies We develop best-in-class solutions to improve patient outcomes. MESSAGE A SPECIALIST DOWNLOADS A Comprehensive Portfolio for the Continuum of Transplant Patient Care For more than 30 years, Immucor has focused on improving patient outcomes by bringing together best-in-class solutions developed to meet specific clinical needs. In addition to offering market-leading assays for typing and screening blood used in lifesaving transfusions, we offer a comprehensive—and progressively expanding—portfolio of products, technologies, and services to support transplant teams across the entire continuum of transplant patient care. PRE-TRANSPLANT EVALUATION ABO Typing and Fully Automated ABO Titrations HLA Typing, Screening and Antibody Identification VIEW PRODUCTS TRANSPLANT-READY Confirm HLA Typing and Cross-match POST-TRANSPLANT SURVEILLANCE Immune Monitoring & Inflammation Monitoring VIEW PRODUCTS kSORT Collection Time Points kSORT can be utilized to monitor patient immune responses to kidney transplantation throughout the transplant journey and can add another perspective to better monitor and prevent graft damage or loss. A suggested protocol driven collection time scenario is presented here to illustrate how kSORT could be used to monitor kidney transplant patients over time. Months 1-6 Test 1x / month Months 7-12 Test every 2 months Months 12+ Test every 6 months WHAT PHYSICIANS ARE SAYING ABOUT kSORT kSORT has the potential to revolutionize the post-transplant care of kidney recipients, by firmly diagnosing acute cellular rejection, and its successful treatment with blood samples. Goran Klintmalm MD, PhD MESSAGE A SPECIALIST DOWNLOADS How to Order kSORT Immucor DX strives to provide excellent customer service, starting with streamlining the logistics of ordering the kSORT test. 1 Order kSORT collection kits Call 1.800.363.5915 or email Immucor DX to order your kSORT Collection kit. 2 Complete test requisition and collect whole blood specimen Complete requisition form and draw specimen in provided PAXgene® tubes according to included instructions. Click here for electronic copies of the test requisition and instructions. 3 Package specimen and contact carrier for pickup Package the specimen and test requisition in accordance with the provided instructions, apply the pre-paid return shipping label, and call carrier for pickup. 4 Receive results in < 1 week Physician receives report within 72 hours of specimen receipt at Immucor DX. Immune Regulation Pathways The kSORT assay evaluates the change in expression of specific genes which are associated with pathways involved with immune activation or stress responses. kSORT gene expression panel has been shown to be valuable in establishing which patients are likely to maintain graft tolerance. The kSORT assay gives health care providers and patients another tool to confirm treatment successes or treatment needs in a complex transplant environment. Immune Regulation Antigen Processing Cell Cycle Regulation Apoptotic Signaling Cytotoxic Granules Immune Differentiation RISK Stress Signaling DUSP1 MAPK9 NAMPT Click on the gene flower petals to learn more. Immune Regulation EPOR is expressed on immune cells and regulates nuclear factor κ light chain enhancer of activated B-cells. CFLAR is an important part of the GPCR superfamily of genes and serves as an important regulator of inflammation. PSEN1 plays an essential role in T-cell receptor activated Notch Signaling. kSORT Data Studies kSORT has been evaluated in multiple studies and demonstrates Negative Predictive Value. In conjunction with standard assessments, kSORT can aid physicians in compiling relevant information to avoid unnecessary biopsies and better predict rejection in kidney transplant patients. STUDY NPV VIEW AART 100 1 93% VIEW STUDY PRISM 2 92% VIEW STUDY SAILOR 3 98% VIEW STUDY ESCAPE 4 90% VIEW STUDY Van Loon Study 5 90% VIEW STUDY 1 Roedder S., Sigdel T., Salomonis N., Sarwai M., et al. PLoS Med. 11, (2014) 2 Vincenti F., et al. Abstract, American Transplant Congress (2018) 3 Ekberg J, Lindner P et al., Am J Transpl. 16, 203–404 (2016) 4 Crespo E., Roedder S., et al. Transplantation 101, 1400–1409 (2017) 5 Van Loon E., et al. Am. J Transpl. 00, 1-11 (2020) Ready to get started? DOWNLOAD THE FORM Speak with a Specialist Do you want to learn more? 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