DAC: Defensive Antibacterial Coating to Protect Implanted Biomaterials From Infection. Home Contacts Antibacterial Hydrogel Coating Protection for Implanted Biomaterials Implanted biomaterials may get colonized by bacteria during surgery... Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room. Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity. VIDEO of biofilm formation An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections. Antibacterial coatings classification DAC (Defensive Antibacterial Coating) is the first fully resorbable coating specifically designed to prevent bacterial colonization of joint prosthesis and osteosynthesis implants. Rationale for Intra-operative Mixing of DAC Hydrogel with Antibiotic(s) VIDEOS The DAC Coating Mechanism of Implant-Related Infection DAC Barrier Effect Surgical Technique Scientific Background Eur J Orthop Traumatol 2021 DAC® Antibacterial Hydrogel Coating for Megaprosthesis National Science Review 2021 Functional Hydrogel Coating Injury 2021 Reconstruction of infected post-traumatic bone defects of the distal femur. Frontiers in Medicine 2020 The Potential Innovative Use of Bacteriophages Within the DAC® Hydrogel Hip International 2020 Antibiotic-loaded Hydrogel Coated Revision Hip Prosthesis Paper of the Week ICM Philly October 13, 2020 Journal of Bone and Joint Infection 2020 Antimicrobial Coated Orthopaedic Implants Efficacy: a Systematic Review and Meta-Analysis ClinicalTrials 2020 Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery Biomolecules 2020 Stability Evaluation and Degradation Studies of DAC® Hyaluronic-Polylactide Based Hydrogel by DOSY NMR Spectroscopy Microorganisms 2020 Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery ECM 2020 Prophylaxis of Implant-Related Infections by Local Release of Vancomycin From a Hydrogel in Rabbits Muscles, Ligaments and Tendons Journal 2020 Defensive Antibacterial Coating (DAC®) for prevention of infection in ACL reconstruction: a feasibility study Traumatology and Orthopedics of Russia 2019 Local Antibacterial Implant Protection in Orthopedics and Trauma: What’s New ? Bone & Joint Research 2019 Antibacterial coating of implants: are we missing something? Eur Rev 2019 Orthopaedic oncology and antibacterial coatings Maitrise Orthopedique Journal 2019 Surgical Technique and Clinical Applications (see full text below) JOA 2018 Cost-benefit balance of DAC and other antibacterial coatings Dr. Willemijn Boot - PhD thesis 2018 Utrecht University, University Medical Center Utrecht, Utrecht, The Netherlands Int Orthop 2018 Two-stage hip revision with DAC coating provides better results than without Hydrogels 2018 Hydrogel coating: from basic research to clinical applications KSSTA 2018 Clinical application to one-stage revision of PJI Orthop Proceedings 2018 Clinical application to two-stage hip revision of PJI Antibacterial Coating of Implants in Ortho-Trauma - Springer Ed. 2018 JORT 2017 Clinical application to osteosynthesis and fracture fixation devices JBJI 2017 Anti-adhesive and anti-bacterial effects of hyaluronic acid CORR 2017 No interference of antibiotic-looaded hydrogel with bone healing in the animal model BJJ 2017-2 BJJ 2017-1 Chapter 9. Infection after Joint Arthroplasy - Thieme Ed. 2017 by A. Chen, CL Romanò, L Drago, J Parvizi JBJI 2016 Clinical application to joint prosthesis BJJ 2016-1 BJJ 2016-2 Med Inflamm 2016 Paradigm change in antibacterial coatings - Springer Ed. 2016 JOSR 2015 Antibacterial Coating of Implants in Orthopaedics and Trauma: A Classification Proposal Orthop Today 2015 CORR 2015 BJJ 2015 The Management of Periprosthetic Infections in the Future eCM 2015 BJJ 2014 CORR 2014 Int Orthop 2014 Biomaterials for Medicine - Universitas Studiorum Ed. 2014 MSIS 2013 Int J Pharm 2013 BJJ 2011 Surgical Tips on Maitrise Orthopedique 2019: Maitrise Orthopedique 2019 [1.868 Kb] A Barrier Against Implant-Related Infections Clinical Indications DAC is a CE marked medical device, specifically designed to protect implanted biomaterials from bacterial adhesion and colonization, in order to reduce or prevent the occurrence of post-surgical infections. The device can be used to protect cementless and hybrid (partially cemented) joint prosthesis (hip, knee, shoulder, etc.), fracture fixation devices (plates, nails, screws, etc.), dental implants, etc.. All patients may take advantage from the antibacterial protection offered by DAC hydrogel, that is especially useful for those patients at higher risk for infection (e.g.: old-aged patients, diabetic and/or obese, smokers, alcohol or drug abusers, immunocompromised hosts, malnurished or oncological patients, etc.) and/or undergoing high risk procedures (revision or tumor surgery, contaminated procedures, etc.). WHITE PAPER 2019 whitepaper2019 [2.790 Kb] FOR MORE INFO www.dac-coating.com D.A.C.: The Result of an International Collaborative Project DAC is the result of a international project, funded by the European Community under the 7th Framework Programme, aimed at developing a resorbable, biocompatible antibacterial coating, able to prevent infection of implanted biomaterials in orthopaedcs. To learn more, visit the official website of iDAC Project Links DAC-Coating DAC in Dutch ! NOVAGENIT 06/12/2021 Invia a un amico © Copyright 2021 DAC: The Implant Coating Protection. All rights reserved. | powered by Register.it - Disclaimer | Mobile