Skip to primary navigation Skip to primary sidebar One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. HOME ABOUT LMB RESEARCH RESEARCH GROUPS STUDENTS RECRUITMENT LIFE AT THE LMB ACHIEVEMENTS NEWS & EVENTS LMB COVID response You can now apply to the LMB International PhD Programme for October 2022 start. About Us The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health. Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists. The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge. The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world. Insight on Research How DNA damage induces appetite suppression and weight loss DNA damage caused by formaldehyde is repaired involving CSA and CSB genes. KJ Patel’s lab have shown how, when this pathway is mutated such as in people with Cockayne syndrome, the appetite suppression hormone GDF15 is released leading to severe weight loss. Early transcriptional patterning of a forming tissue is essential to morphogenesis of a tubular organ Time-lapse quantitative study of developing salivary glands in Drosophila embryos, conducted by Katja Röper’s group, reveals the key control factors behind cells’ behavioural transitions that are essential for correct organ formation. See more Insight on Research Quick Links How to Find Us Current Vacancies Ahead of the Curve LMB@60 Contact Directory PhD Programme Women in Science Seminars Useful Contacts Goals and Research Focus LMB Nobel Prizes News & Events Latest News César Milstein Lecture to be given by Hans Clevers Hans Clevers from the Hubrecht Institute will deliver the 2021 César Milstein Lecture on how organoids can be used to model human diseases. […] Francis Crick Lecture to be given by Michel C. Nussenzweig Michel C Nussenzweig from Rockefeller University will deliver the 2021 Francis Crick Lecture on human immune responses to SARS-CoV-2 infection or vaccination […] See more News LMB in the News Endless forms most beautiful Heart cell clocks help coordinate daily cardiac function See more LMB in the News LMB Alumni News Kenneth Holmes 1934 – 2021 The life and work of Robert C. Sheppard – pioneer of peptide synthesis See more LMB Alumni News Latest Publications Complete atomic structure of a native archaeal cell surface. von Kügelgen, A., Alva, V., Bharat, TAM. Cell Rep 37(8): 110052. (23rd November 2021) Insights into neurodegeneration from electron microscopy studies. Crowther, RA. Biochem Soc Trans [Epub ahead of print]. (23rd November 2021) Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors. Ivica, J., Lape, R., Sivilotti, LG. J Physiol [Epub ahead of print]. (21st November 2021) A model of impaired Langerhans cell maturation associated with HPV induced epithelial hyperplasia. Tuong, ZK., et al. iScience 24(11): 103326. (19th November 2021) MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Yu, Q., Herrero Del Valle, A., Singh, R., Modis, Y. Nat Commun 12(1): 6668. (18th November 2021) New tools for automated cryo-EM single-particle analysis in RELION-4.0. Kimanius, D., Dong, L., Sharov, G., Nakane, T., Scheres, SHW. Biochem J [Epub ahead of print]. (16th November 2021) High-resolution mapping of metal ions reveals principles of surface layer assembly in Caulobacter crescentus cells. Herdman, M., et al. Structure [Epub ahead of print]. (15th November 2021) See more Publications Privacy & Cookies Contact Directory Freedom of Information Site Map Find Us ©2021 MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. 01223 267000 The MRC is part of UK Research and Innovation The LMB may use cookies to analyse how you use our website. We use external analysis systems which may set additional cookies to perform their analysis. These cookies (and any others in use) are detailed in our Privacy and Cookies Policy and are integral to our website. 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