MENU Scientific Advisory Board World-class scientific experts guide Akcea development programs. John Kastelein, MC, PhD, FESC Professor of Medicine, Chairman of the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam READ BIO Joseph Witztum, MD Professor of Medicine, Department of Medicine and Director, Atherosclerosis Research Group, University of California, San Diego READ BIO Sotirios (Sam) Tsimikas, MD Professor of Medicine and Director of Vascular Medicine at the University of California, San Diego, Vice President, Clinical Development, Ionis Pharmaceutical, Inc. READ BIO Rosanne Crooke, PhD Vice President, Cardiovascular Disease Antisense Drug Discovery, Ionis Pharmaceuticals READ BIO Careers | Privacy Policy | Terms of Use | Contact | Compliance Governance Documents Akcea Therapeutics 22 Boston Wharf Road, 9th Floor, Boston MA 02210 (617) 207-0202 info@akceatx.com © 2021, all rights reserved Akcea Therapeutics has been acquired by Ionis Pharmaceuticals. For continued news and information about Akcea Therapeutics, please visit ionispharma.com. You are being redirected, please wait. If you have not been redirected in 30 seconds, please click the button below. Go to ionispharma.com

MENU Vision & Mission Akcea Therapeutics is a development and commercialization company focused on helping patients living with serious and rare diseases. Our priority is to bring transformative medicines to patients by driving clinical program execution, understanding patient and physician needs, preparing the market, creating market access, and commercializing our products on a global basis. We are driven by the knowledge that patients depend on us. Akcea, a wholly-owned subsidiary of Ionis Pharmaceuticals, was established in early 2015 and based in the Seaport District in Boston, Massachusetts. Akcea has a robust portfolio of development- and registration-stage drugs covering multiple targets and diseases using advanced RNA-targeted antisense therapeutics. Our immediate focus is to drive our clinical programs forward through development to commercialization while building on the Ionis standards of excellence. Careers | Privacy Policy | Terms of Use | Contact | Compliance Governance Documents Akcea Therapeutics 22 Boston Wharf Road, 9th Floor, Boston MA 02210 (617) 207-0202 info@akceatx.com © 2021, all rights reserved Akcea Therapeutics has been acquired by Ionis Pharmaceuticals. For continued news and information about Akcea Therapeutics, please visit ionispharma.com. You are being redirected, please wait. If you have not been redirected in 30 seconds, please click the button below. Go to ionispharma.com