All Webinars Whole-Body MRI Composite Scoring in Neuromuscular Disease Research & Muscle Health The recorded webinar will soon be uploaded. Please come back in a couple of days. Neuromuscular disorders (NMDs) are generally variably progressing, rare diseases causing devastating skeletal muscle injury resulting in severe disability and even death. In the intensive search for treatments and cures, MRI has emerged as a promising clinical and drug development tool that can detect early disease progression and treatment effects before loss of muscle function or disability can be observed with clinical assessments. Muscle atrophy and muscle fat replacement are hallmarks of NMDs. Most NMDs are characterized by heterogeneity in the pattern and timing of muscle involvement among patients. This causes significant variability and leads to challenges in the assessment of potential treatment effects. Recent technical advances have led to the development of muscle biomarkers based on whole-body water and fat separated MRI that can describe the distribution and progression of muscle atrophy and fat replacement with high precision and accuracy. Imaging the whole body enables the identification of a personalized set of affected muscles, decreasing the variability and increasing the sensitivity of efficacy assessment. In this webinar, two experts will review techniques for whole-body MRI and its application in NMD clinical research. Technical aspects will be discussed, including: Practical implementation of MRI scanning protocols Image analysis techniques Biomarker definitions How challenges related to multi-site implementation can be addressed Further, featured speakers will discuss how measurements from multiple muscles based on a whole-body MRI scan can be combined into composite scores optimized to describe specific aspects of disease onset pattern, functional impairment, and disease progression between scans. Finally, experiences from recent clinical trials in facioscapulohumeral muscular dystrophy (FSHD) will be discussed exemplifying how such composite scores can be used as endpoints. Register for this webinar to learn how whole-body MRI can support NMD clinical research. WEBINAR DATE 23 November 2021 Markus Karlsson, PhD Clinical Science Lead AMRA MEDICAL Read more Michelle L. Mellion, MD Executive Medical Director , Head of Neuromuscular Clinical Development FULCRUM THERAPEUTICS Read more What you will learn • Advantages of whole-body MRI techniques for NMD research • Addressing multi-site MRI scanning protocol implementation • Exploring early disease progression and treatment effects with MRI • Discuss the heterogenous presentation of most NMDs • Using composite scores as endpoints in recent FSHD clinical trials Who should attend? • Chief Medical Officer • Chief Executive Officer • Neuromuscular Clinicians • Principal Investigator • Medical Director • Research Nurse • Clinical Director • Clinical Project Manager • Imaging Specialist • Clinical Operations • Clinical Development Manager • Physical Therapist • Occupational Therapist • Procurement Manager • Statistician • Data Manager • Regulatory Coordinator • Business Development AMRA Medical is a digital health company at the forefront of medical imaging and precision medicine. The company has developed a new global standard in body composition analysis, delivering multiple fat and muscle biomarkers with unrivaled accuracy and precision – all from a rapid whole-body MRI scan. AMRA offers medical device and medical research services to support transformative care and vital decision-making, from clinical research to clinical care. Contact info@amramedical.com +46 (0) 13 16 26 00 Contact Our Support Follow us Newsletter I agree that AMRA registers the above information and gives me information about services, products etc. via email. Read more about our privacy policy. Data Privacy Policy Cookies © 2021 AMRA MEDICAL AB By using our site, you acknowledge that you have read and understood our privacy policy. We use cookies to ensure you have the best browsing experience on our website. Accept & Close