WHY EPAX® PRODUCTS SCIENCE ECOVISION CONTACT US NEWS Taking an active role in Omega-3 Science Epax® supports unbiased science. The safety and efficacy of our products have been demonstrated in over 100 peer-reviewed clinical studies ― more than any other marine Omega-3 company. This body of research covers a wide range of categories, including cardiovascular health, joint health, dementia, obstetrics and immunology. Cardiovascular Health von Schacky C, Angerer P, Kothny W. Et al. The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann.Intern.Med. 1999;130:554-562 von Schacky C, Baumann K, Angerer P. The effect of n-3 fatty acids on coronary atherosclerosis: results from SCIMO, an angiographic study, background and implications.LIPIDS 2001;36:S99-S102 Lervang HH, Schmidt EB, Møller JM. Et al. The effect of low-dose supplementation with n-3 polyunsaturated fatty acids on some risk markers of coronary heart disease. Scand J Clin Lab Invest 1993;53:417-423 Markmann P, Lerche C, Nørtoft LL. A critical view on using fish-oil in prevention of ischaemical heart disease. Ugeskr Laeger 1992;154:2288-2292 Schmidt EB. n-3 fatty acids and the risk of coronary heart disease. Dan.Med.Bull 1997;44:1-22 Marckmann P, Bladbjerg EM, Jespersen J et al. Dietary fish oil (4 g daily) and cardiovascular risk markers in healthy men. Arterioscler.Thromb.Vasc.Biol. 1997;17:3384-3391 Rees D, Miles EA, Banerjee T, et al. Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. American.journal of clinical.nutrition 2006;83:331-342 Cazzola R, Russo-Volpe S, Miles EA, et al. Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects. Atherosclerosis 2007;193:159-167 Einvik G, Klemsdal TO, Sandvik L et al. A randomized clinical trial on n-3 PUFA supplementation and all-cause mortality in elderly men at high cardiovascular risk. Eur J Cardiovasc Rehab 2010;17:588-592 Hjerkinn EM, Abdelnoor M, Breivik L et al. Effect of diet or very long chain omega-3 fatty acids on progression of atherosclerosis, evaluated by carotid plaques, intima-media thickness and by pulse wave propagation in elderly men with hypercholesterolaemia. European Journal of Cardiovascular Prevention and Rehabilitation 2006;13:325-333 Dyerberg J, Eskesen DC, Andersen PW et al. Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. European.journal of clinical.nutrition 2004;58:1062-1070 Dyerberg J, Christensen JH, Eskesen D et al. Trans, and n-3 polyunsaturated fatty acids and vascular function-A yin yang situation. Atherosclerosis.Supplements 2006;33-35 Schmidt EB, Varming K, Pedersen JO et al. Long-term supplementation with n-3 fatty acids. Scan J Clin Lab Invest 1992;52:229-236 Wu S-Y, Mayneris-Perxachs J, Lovegrove JA, Todd S, and Yaqoob P. Fish-oil supplementation alters numbers of circulating endothelial progenitor cells and microparticles independent of eNOS genotype. AJCN 2014 doi: 10.3945/ajcn.114.088880. Minihane AM, Khan S, Leigh-Firbank EC et al. ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Atheriosclerosis, thrombosis, and vascular biology 2000;20:1990-1997 Nordøy A, Hatcher LF, Ullman DL et al. Individual effects of dietary saturated fatty acids and fish oil on plasma lipids and lipoproteins in men. Am J Clin Nutr 1993;57:634-639 Schmidt EB, Ernst E, Varming K et al. The effect of n-3 fatty acids on lipids and haemostasis in patients with Type IIa and Type IV hyperlipidemia. Thromb Haemostas 1989;62:797-801 Schmidt EB, Sørensen PJ, Pedersen JO et al. The effect of n-3 polyunsaturated fatty acids on lipids, haemostasis, neutrophil and monocyte chemotaxis in insulin-dependant diabetes mellitus. J Intern Med 1989;225 (suppl):201-206 Schmidt EB, Varming K, Ernst E et al. Dose-response studies on the effect of n-3 polyunsaturated fatty acids on lipids and haemostasis. Tromb Haemostas 1990;63:1-5 Schmidt EB, Pedersen JO, Varming K et al. N-3 fatty acids and leucocyte chemotaxis. Effects in hyperlipidaemia and dose-response studies in healthy men. Arterosclerosis and Thrombosis 1991;11:429-435 Schmidt EB, Klausen IC, Kristensen SD et al. The effect of n-3 polyunsaturated fatty acids on Lp(a). Clin Chim Acta 1991;198:271-278 Schmidt EB, Varming K, Svaneborg N et al. N-3 polyunsaturated fatty acid supplementation in men with moderate and severe hypertriglyceridemia: a dose-response study. Ann Nutr Metab 1992;36:283-287 Schmidt EB, Lervang HH, Varming K et al. Long-term supplementation with n-3 fatty acids: effects on blood lipids, haemostasis and blood pressure. Scand J Clin Lab Invest 1992;52:221-228 Svaneborg N, Møller JM, Schmidt EB et al. The acute effects of a single very high dose of n-3 fatty acids on plasma lipids and lipoproteins in healthy subjects. Lipids 1994;29:145-147 Stark KD, Park EJ, Maines VA et al. Effect of a fish-oil concentrate on serum lipids in postmenopausal women receiving and not receiving hormone replacement therapy. Am J Clin Nutr 2000;72:389-394 Seljeflot I, Johansen O, Arnesen H et al. Procoagulant activity and cytokine expression in whole blood cultures from patients with atherosclerosis supplemented with omega-3 fatty acids. Thromb.Haemost. 1999;81:566-570 Lindman AS, Pedersen JI, Hjerkinn EM et al. The effects of long-term diet and omega-3 fatty acid supplementation on coagulation factor VII and serum phospholipids with special emphasis on the R353Q polymorphism of the FVII gene. Thrombosis.and haemostasis 2004;6:1097-1104 Barstad RM, Roald HE, Petersen LB et al. Dietary supplementation of omega-3 fatty acids has no effect on acute collagen induced thrombus formation in flowing native blood. Blood Coagul Fibrinolysis. 1995;6:374-381 Flaten H, Høstmark AT, Kierulf P et al. Fish-oil concentrate: effects on variables related to cardiovascular disease. Am J Clin Nutr 1990;52:300-306 Freese R, Mutanen M. Alpha-linolenic acid and marine long-chain n-3 fatty acids only slightly differ in their effects on haemostatic factors in healthy subjects. Am J Clin Nutr 1997;66:591-598 Freese R, Mutanen M. Small effects of linseed oil or fish oil supplementation on postprandial changes in hemostatic factors. Thromb Res 1997;85(2):147152 Freese R. Dietary fatty acids and hemostasis. Effects of n-3 and n-6 fatty acids on platelet function and coagulation in healthy subjects. 1997;Uni Helsinki 75 Müllertz A, Hølmer G, Grøndahl-Hansen J et al. Increased concentration of plasminogen activator inhibitor type-1 in plasma after intake of fish oil. Fibrinolysis 1990;4(suppl 2):86-88 Christensen JH, Gustenhoff P, Korup E et al. n-3 polyunsaturated fatty acids, heart rate variability and ventricular arrhythmias in post-AMI-patients. A clinical controlled trial. Ugeskr.Laeger 1997;159:5526-5529 Christensen JH, Gustenhoff P, Korup E et al. Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial. BMJ 1996;312:677-678 Christensen JH, Gustenhoff P, Ejlersen E et al. n-3 fatty acids and ventricular extrasystoles in patients with ventricular tachyarrhythmias. Nutrition Res 1995;15:1-8 Christensen JH, Gustenhoff P, Korup E et al. n-3 fatty acids and ventricular arrhythmias in post-myocardial infarction patients with a low ejection fraction 1995;10:107-114 Christensen JH, Christensen MS, Dyerberg J et al. Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n-3 fatty acids. Am J Clin Nutr 1999;70:331-337 Christensen JH, Aarøe J, Knudsen N et al. Heart rate variability and n-3 fatty acids in patients with chronic renal failure. Clin Neprol 1998;49:102-106 Kumar S, Sutherland F, Wheeler M, Heck PM, Lee G, Teh AW, Manohar LG, Morgan JG, Sparks PB. Effects of chronic omega-3 polyunsaturated fatty acid supplementation on human atrial mechanical function after reversion of atrial arrhythmias to sinus rhythm: Reversal of tachycardia-mediated atrial cardiomyopathy with fish oils. Heart Rhythm 2011;8:643-649 Seljeflot I, Arnesen H, Brude IR et al. Effects of omega-3 fatty acids and/or antioxidants on endothelial cell markers. Eur.J.Clin.Invest. 1998;28:629-635 Berstad P, Seljeflot I, Veierod MB et al. Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clinical.science 2003;105:13-20 Eid H, Arnesen H, Hjerkinn EM et al. Effect of diet and omega-3 fatty acid intervention on asymmetric dimethylarginine. Nutrition & Metabolism 2006;3:4 Furenes EB, Seljeflot I, Solheim S et al. Long-term influence of diet and/or omega-3 fatty acids on matrix metalloproteinase-9 and PAPP-A in men at high risk of coronary heart disease. SCLI 2008;68:177-184 Bonnema SJ, Jespersen LT, Marving J et al. Supplementation with olive oil rather than fish oil increases small arterial compliance in diabetic patients Diab Nutr & Metabol 1995;8:81-87 Hjerkinn EM, Seljeflot I, Ellingsen I et al. Influence of long-term intervention with dietary counseling, long-chain n-3 fatty acid supplements, or both on circulating markers of endothelial activation in men with long-standing hyperlipidemia. American.journal of clinical.nutrition 2005;81:583-589 Christensen JH, Therkelsen K, Møller JM et al. n-3 fatty acids do not decrease plasma endothelin levels in healthy individuals. Scan J Clin Invest 1997;57:495-500 Fashing P, Ratheiser K, Waldhäusl W et al. Metabolic effects of fish-oil supplementation in patients with impaired glucose tolerance. Diabetes 1991;40:583-589 Fashing P, Rohac M, Liener K et al. Fish oil supplementation versus gemfibrozil treatment in hyperlipidemic NIDDM. Horm Metab Res 1996;28:230-236 Troseid M, Seljeflot I, Hjerkinn EM et al. Il-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome. Diab Care 2008;32:486-492 Kamolrat T, Gray SR, and Thivierge MC. Fish oil positively regulates anabolic signalling alongside an increase in whole-body gluconeogenesis in ageing skeletal muscle. Eur J Nutr 2013;52(2):647-657 Flachs P, Rossmeisl M, and Kopecky J. The effect of n-3 fatty acids on glucose homeostasis and insulin sensitivity. Physiol Res 2014;63(1): 93-118 Kopecky J, et al. Combined intervention with Pioglitazone and n-3 fatty acids in metformin-treated diabetic patients on postprandial lipid clearance and selected cytokines. Nutrition & Metabolism NUAM-D-15-00080R1 Razny,U., Kiec-Wilk,B., Polus,A., Goralska,J., Malczewska-Malec,M., Wnek,D., Zdzienicka,A., Gruca,A., Childs,C.E., Kapusta,M., Slowinska-Solnica,K., Calder,P.C., and Dembinska-Kiec,A. (2015) Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects: A randomized placebo controlled trial, BBA clinical 4, 7-13. Bas JM, Caimari A, Rodriguez-Naranjo MI, Childs CE, Chavez CP, West AL, Miles EA, Arola L, Calder PC. Impairment of lysophospholipid metabolism in obesity: altered plasma profile and desensitization to the modulatory properties of n–3 polyunsaturated fatty acids in a randomized controlled trial. Am J Clin Nutr 2016;104:266-279 Razny Urszula, Beata Kiec-Wilk, Anna Polus, Joanna Goralska, Malgorzata Malczewska-Malec, Dominika Wnek, Anna Zdzienicka et al. 2015. Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects: a randomized placebo controlled trial. BBA Clinical 2015;4:7–13 Clark,L.F., Thivierge,M.C., Kidd,C.A., McGeoch,S.C., Abraham,P., Pearson,D.W.M., Horgan,G.W., Holtrop,G., Thies,F., and Lobley,G.E. (2016) Fish oil supplemented for 9 months does not improve glycaemic control or insulin sensitivity in subjects with impaired glucose regulation: a parallel randomised controlled trial, The British journal of nutrition 115, 75-86 Polus A, Zapala B, Razny U, Gielicz A, Kiec-Wilk B, Malczewska-Malec M, Sanak M, Childs CE, Calder PC, Dembinska-Kiec A. Omega-3 fatty acid supplementation influences the whole blood transcriptome in women with obesity, associated with pro-resolving lipid mediator production. Biochim Biophys Acta. 2016;1861(11):1746-1755 Rohith N. Thota, Shamasunder H. Acharya and Manohar L. Garg. Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial, Thota et al. Lipids in Health and Disease (2019) 18:31 https://doi.org/10.1186/s12944-019-0967-x Rheumatology Espersen GT, Grunnet N, Lervang HH et al. Decreased interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids. Clin Rheum 1992;11(3):393-395 Faarvang KL, Nielsen, Thomsen BS et al. Fish oil and rheumatoid arthritis: a randomised double-blind study. Ugeskrift Laeger 1994;156:3495-3498 Hansen GVO, Nielsen L, Kluger E et al. Nutritional status of Danish rheumatoid patients and effects of a diet adjusted in energy intake, fish-oil and antioxidants. Scand J Rheumatol 1996;25:325-330 Nielsen GL, Faarvang BS, Thomsen BS et al. The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis. Eur J Clin Invest 1992;22:687-691 Volker DH, Fitzgerald P, Major G et al. Efficacy of a fish-oil concentrate in the treatment of rheumatoid arthritis. J Rheumatol 2000;27:2343-2346 Sundstrom B, Stalnacke K, Hagfors L et al. Supplementation of omega-3 fatty acids in patients with ankylosing spondylitis. Scandinavian journal of rheumatology. 2006;39:359-362 Dementia Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T et al. Omega-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial. Archives of neurology 2006;63:1402-1408 Freund-Levi Y, Basun H, Cederholm T et al. Omega-3 supplementation in mild to moderate Alzheimer’s disease: effects on neuropsychiatric symptoms. Internat J Geriatric Psych 2008;23(2):161-169 Faxen-Irving G, Freund-Levi Y, Eriksdotter Jonhagen M, et al. N-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer’s disease. Journal Am Geriatric Soc 2009;57:11-17 Vedin I, Cederholm T, Freund Levi Y, et al. Effects of docosahexaenoic acid–rich n3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study. Am J Clin Nutr 2008;87:1616 –22 Lai KL, Shahar S, Chin AV, et al. Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. Psychopharmacology 2013;225:605–612 Lai KL, Shahar S; Rajab N, et al. The role of long chain omega-3 polyunsaturated fatty acids in reducing lipid peroxidation among elderly patients with mild cognitive impairment: a case-control study. Journal of nutritional biochemistry 2013; 24 (5):803-808 Faxen-Irving G, Freund-Levi Y, Eriksdotter-Jonhagen M, et al. Effects on Transthyretin in Plasma and Cerebrospinal Fluid by DHA-Rich n - 3 Fatty Acid Supplementation in Patients with Alzheimer's Disease: The OmegAD Study. Journal of Alzheimer's disease 2013;36(1):1 - 6 Nolan, J. M., Mulcahy, R., Power, R., Moran, R., & Howard, A. N. (2018). Nutritional Intervention to Prevent Alzheimer's Disease: Potential Benefits of Xanthophyll Carotenoids and Omega-3 Fatty Acids Combined. J Alzheimers Dis, 64(2), 367-378. doi:10.3233/jad-180160 Obstetrics Olsen SF, Sørensen JD, Secher NJ et al. A randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet 1992;339:1003-1007 Olsen SF, Sørensen JD, Secher NJ et al. Fish-oil supplementation and pregnancy duration: a randomised controlled trial. Ugeskr Laeger 1994;156:1302-1307 Olsen SF, Secher NJ, Tabor A et al. Randomised clinical trial of fish oil supplementation in high risk pregnancies. Brit J Obstet Gynecol 2000;107:382-395 Salvig JD, Olsen SF, Secher NJ. Effects of fish oil supplementation in late pregnancy on blood pressure: a randomised controlled trial. Brit J Obstet Gynecol 1996;103:529-533 Sørensen JD, Olsen SF, Pedersen AK et al. Effects of fish oil supplementation in the third trimester of pregnancy on prostacyclin and thromboxane production. Am J Obstet Gynecol 1993;168:915-922 Sørensen JD, Olsen SF, Secher NJ et al. Effects of fish oil supplementation in late pregnancy on blood lipids, serum urate, coagulation and fibrinolysis: a randomised controlled study. Fibrinolysis 1994;8:54-60 Vanhouwelingen AC, Sørensen JD, Hornstra G et al. Essential fatty acid status in neonates after fish-oil supplementation during late pregnancy Br J Nutr 1995;74:723-731 Olsen SF, Osterdal ML, Salvig JD et al Duration of pregnancy in relation to fish oil supplementation and habitual fish intake: a randomised clinical trial with fish oil. European journal of clinical nutrition; 2007;61(8): 976-85 Freeman MP, Hibbeln JR, Wisner KL et al. Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression. Acta psychiatrica Scandinavica 2006;113:31-35 Klingler M, Blaschitz A, Campoy C et al. The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation. British Journal of Nutrition 2006;96:182-190 Barque E, Krauss-Etschmann S, Campoy C et al. Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. American Journal of Clinical Nutrition 2006;84:853-861 Shoji H, Franke C, Campoy C et al. Effect of docosahexaenoic acid and eicosapentaenoic acid supplementation on oxidative stress levels during pregnancy. Free Radical Research 2006;40:379-384 Immunology Mølvig J, Pociot F, Worsaae H et al. Dietary supplementation with n-3 polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin-beta content but not monokine secretion in healthy and insulin-dependent diabetic individuals. Scand J Immunol 1991;34:399-410 Schmidt EB, Varming K, Møller JM et al. No effect of a very low dose of n-3 fatty acids on monocyte function in healthy humans. Scan J Lab Invest 1996;56:87-92 Toft AD, Thorn M, Ostrowski K et al. N-3 polyunsaturated fatty acids do not affect cytokine response to strenous exercise. J Appl Physiol 2000;89:2401-2406 Varming K, Schmidt EB, Svaneborg N et al. The effect of n-3 fatty acids on neutrophil chemiluminiscience. Scand J Clin Lab Invest 1995;55:47-52 Rees D, Miles EA, Banerjee T et al. Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am J Clin Nutr 2006;83:331-342 Josep M del Bas, Antoni Caimari, Maria Isabel Rodriguez-Naranjo et al. Impairment of lysophospholipid metabolism in obesity: altered plasma profile and desensitization to the modulatory properties of n–3 polyunsaturated fatty acids in a randomized controlled trial. Am J Clin Nutr 2016;104:266–79 Williams EJ, Baines KJ, Smart JM, Gibson PG, Wood LG. Rosuvastatin, Lycopene and Omega-3 fatty acids: A potential treatment for systemic inflammation in COPD; a pilot study. J of Nutr & Intermediary Metabolism. 2016;5:86-95 Safety Schmidt EB, Moller JM, Svaneborg N et al. Safety aspects of fish oils: experience with an n-3 concentrate of reesterified triglycerides. Drug Invest 1994;7:215-220 Schmidt EB, Moller JM, Svaneborg N et al. Prevention and treatment of vascular disease. Safety aspects of dietary n-3 fatty acids. Springer Verlag 1995;18:195-206 Miscellaneous Bioavailability: Dyerberg J, Madsen P, Møller JM et al. N-3 fatty acids in prevention and treatment in vascular disease. Springer Verlag 1995;20:201-217 Bioavailability: Nordøy A, Barstad L, Connor WE et al. Absorption of the n-3 eicosapentaenoic and docosahexaenoic acids as ethyl esters and triglycerides by humans. Am J Clin Nutr 1991;53:1185-1190 Bioavailability: Dyerberg J, Madsen P, Møller JM. Bioavailability of n-3 fatty acid formulations. Springer Verlag 1995;20:217-226 Transplantation: Hansen JM, Løkkegaard H, Hoy CE et al. No effect of dietary fish oil on renal hemodynamics, tubular function, and renal function reserve in long-term renal transplant recipients. J Am Soc Nephrol 1995;5:1434-1440 Transplantation: Hansen JM, Hoy CE, Strandgaard. Fish oil and cyclosporin A induced renal hypoperfusion in kidney-transplanted patients. Nephrology Dialysis Transplantation 1995;10:1745-1750 Physical performance: Raastad T, Høstmark AT, Strømme SB. Omega-3 fatty acid supplementation does not improve maximal aerobic power, anaerobic threshold and running performance in well-trained soccer players. Scand J Med Sci Sports 1997;7:25-31 Digestion: Riber C, Højgaard L, Madsen JL et al. Gallbladder emptying and cholecystokinin response to fish oil and trioleate ingestion. Digestion 1996;57(3):161-164 Weight reduction: Kunnesova M, Srbova L, Hlavaty P et al. Praha omega-3 weight reduction study. ECO 2008; abstract Infection: Abu-Zeid YA, Hansen HS, Jakobsen PH et al. No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on plasmodium falciparum bloodstage parasites in vitro. Eur J Clin Nutr 1993;47:431-436 Depression: Voggt A, Berger M, Obermeier M, Löw A, Seemueller F, Riedel M, Moeller HJ, Zimmermann R, Kirchberg F, Von Schacky C, Severus E. Heart rate variability and Omega-3 Index in euthymic patients with bipolar disorders. Eur Psychiatry 2015:30(2):228-232 Depression: Parletta N, Zarnowiecki D, Cho J, Wilson A, Bogomolova S, Villani A. A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED). Nutritional Neuroscience 2017;1411320 Analysis: Sjövall,P., Rossmeisl,M., Hanrieder,J., Kuda,O., Kopecky,J., and Bryhn,M. Dietary uptake of omega-3 fatty acids in mouse tissue studied by time-of-flight secondary ion mass spectrometry (TOF-SIMS), Analytical and bioanalytical chemistry 2015;407:5101-5111. Psychotic Disorders: McGorry PD, Nelson B, Markulev C. Effect of ω-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders; The NEURAPRO Randomized Clinical Trial. JAMA Psychiatry 2017;74(1):19-27 Psychotic Disorders: Amminger GP, Schafer MR, Schlogelhofer M, Clier CM, McGorry PD. Longer-term outcome in the prevention of psychotic disorders by the Vienna Omega-3 study. Nature communications 2015;6:7934 Eye Health: McDonald MB, Sheha H, Tighe S, Janik SB, Bowden FW, Chokshi AR, Singer MA, Nanda S, Qazi MA, Dierker D, Shupe AT, McMurren BJ. Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study. Clin Ophthalmol. 2018 Apr 9;12:677-681 Metabolic Syndrome: Abbott, K., Burrows, T. L., Acharya, S., Thota, R. N., & Garg, M. L. (2020). Dietary supplementation with docosahexaenoic acid rich fish oil increases circulating levels of testosterone in overweight and obese men. Prostaglandins Leukot Essent Fatty Acids, 163, 102204. doi:10.1016/j.plefa.2020.102204 Metabolic Syndrome: Abbott, K. A., Burrows, T. L., Acharya, S., Thota, R. N., & Garg, M. L. (2020). DHA-enriched fish oil reduces insulin resistance in overweight and obese adults. Prostaglandins Leukot Essent Fatty Acids, 159, 102154. doi:10.1016/j.plefa.2020.102154 Metabolic Syndrome: Thota, R. N., Acharya, S. H., & Garg, M. L. (2019). Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial. Lipids Health Dis, 18(1), 31. doi:10.1186/s12944-019-0967-x Metabolic Syndrome: Thota, R. N., Rosato, J. I., Burrows, T. L., Dias, C. B., Abbott, K. A., Martins, R. N., & Garg, M. L. (2020). Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults. Nutrients, 12(6). doi:10.3390/nu12061612 WHY EPAX® Our philosophy Vertical integration About us PRODUCTS Product overview About Omega-3 SCIENCE Condition-specific Clinical trials ECOVISION Traceability Sustainability Acountability Contact us to discover how our experience with the condition-specific Omega-3 concentrate industry can improve your business Epax © 2021