A promising pipeline Take a closer look at the progress of our first-in-class therapeutics. Drug Indication* Phase I Phase II Phase III FDA Approved Commercialization Rights† (ex-Japan and S. Korea)‡ Pruritus Difelikefalin injection Pruritus CKD-HD§ US-Vifor EU / Other-VFMCRP|| Oral difelikefalin Pruritus AD Cara Oral difelikefalin Pruritus NDD-CKD Cara Oral difelikefalin Pruritus PBC Cara Oral difelikefalin Pruritus NP Cara *Cara Therapeutics has investigated difelikefalin for post-operative pain. †Vifor has commercial rights in Non-US Fresenius Medical Care dialysis clinics under a profit-share arrangement. ‡Commercialization rights to difelikefalin in defined indications—Japan: Maruishi Pharma; South Korea: CKD Pharma. §Approved for USA. ||VFMCRP and Cara have rights to promote in Fresenius clinics in the US under a profit-share agreement. CKD-HD: Chronic Kidney Disease-Hemodialysis; NDD—CKD: Non-Dialysis Dependent-Chronic Kidney Disease; AD: Atopic Dermatitis; PBC: Primary Biliary Cholangitis; NP: Notalgia Paresthetica. HOME WHAT WE DO FOR PATIENTS WHO WE ARE NEWS & INVESTORS CONTACT ©2021 Cara Therapeutics. All rights reserved. | Privacy Policy | Sitemap | Terms of Use

Skip to main navigation Historic Stock Lookup Lookup Month November Lookup Day 25 Lookup Year 2021 Week of Nov 22, 2021 Date Requested Closing Price Volume Split Adjustment Factor Open Price Day High Day Low Nov 22, 2021 $13.63 737,991 1:1 $14.16 $14.45 $13.50 Nov 23, 2021 $13.44 940,034 1:1 $13.58 $13.92 $13.24 Nov 24, 2021 $13.34 521,644 1:1 $13.26 $13.46 $13.06 Year End Stock Prices NOTE: The Closing Price, Day's High, Day's Low, and Day's Volume have been adjusted to account for any stock splits and/or dividends which may have occurred for this security since the date shown above. The Split Adjustment Factor is a cumulative factor which encapsulates all splits since the date shown above. The closing price above is not necessarily indicative of future price performance. Data Provided by Refinitiv. Minimum 15 minutes delayed. Contact IR Email Alerts HOME WHAT WE DO FOR PATIENTS WHO WE ARE NEWS & INVESTORS CONTACT ©2021 Cara Therapeutics. All rights reserved. | Privacy Policy | Sitemap | Terms of Use

Skip to main navigation Contact Us Please submit your question using the form below. * Indicates required field Name Email Subject Comments Contact IR Email Alerts HOME WHAT WE DO FOR PATIENTS WHO WE ARE NEWS & INVESTORS CONTACT ©2021 Cara Therapeutics. All rights reserved. | Privacy Policy | Sitemap | Terms of Use