Quick Links PATIENT-CENTRIC SOLUTIONS Taste Masking Adare Pharma Solutions is a world leader in organic-phase coacervation for pharmaceutical products. Our proprietary taste masking platforms can improve product acceptability and patient adherence Increasingly, format flexibility is becoming a requirement to address patient issues such as swallowing. The FDA also continues to push for pediatric-friendly formulations. Taste, smell, and mouth feel are the key product features to address when developing pediatric formulations. And Incremental formulation and clinical research costs require cost-effective solutions with flexibility in manufacturing scale. These drivers are why customers continue to come back to Adare Pharma Solutions for their taste-masking challenges. Among various taste masking strategies, physical barrier is one of the most efficient technologies, and Adare offers industrially feasible physical barrier technologies, such as Microcaps® and Optimµm®, for taste masking and dosage forms for pediatric populations. Microencapsulation by coacervation: As the world leader in coacervation, Adare’s Microcaps® technology is widely scene as the industry leading taste-masking solution with a wide variety of delivery formats. Uniform coating of a solid particle or liquid droplet with a rigid semi-permeable polymer Creates a physical barrier: Effective taste masking Customized release profile Turn liquids into powders Combine incompatible APIs Final dosage forms: Powder Dry syrup Orally disintegrating tablets Parvulet® dosage form: food-like texture Core In the manufacturing vehicle Deposition of Gel-like coating Completed Capsules Proprietary Taste-Masking Process Although spherical particles are shown (yellow), the Microcaps® coacervation process can also be used for varying non-isometric particle shapes. Our Process Also Offers: Small Particle Size – down to 150-200 µm Highly efficient coating – usually 10-20% Tunable and reproducible dissolution profile Short processing time – one shift Processing time not impacted by coating amount High manufacturing capacity Can manage different particle shapes Adare’s Optimµm® technology provides innovative taste masking opportunities not seen before in oral pharmaceutical products Optimµm® is developed and manufactured through Adare’s Precision Particle Fabrication™ technology, which produces uniform microspheres and microcapsules. Optimµm® is an elegant and robust solution with countless applications. You can learn more about how Optimµm® is manufactured using Precision Particle Fabrication™, here. Optimµm® Multiparticulates are able to deliver: Uniformity Format Flexibility Dose Flexibility Taste Masking Variable Release Kinetics Single-step Microcapsules The Broadest Variety of Taste-Masking Solutions in the Industry Adare Pharma Solutions employs a variety of strategies for achieving successful taste-masking results for our customers, including: API Taste Modifiers or Suppressants Sweeteners Flavors Bitter receptor blocker or antagonists Potentiators Effervescents API Solubility Modifier pH Modifier Gellation or Viscosity Enhancer API Barrier Molecular/Ionic Barrier via complexation [Ion exchange resins or cyclodextrins] Physical barrier via coating or granulation, etc. [polymers or lipids or similar excipients] API Modification Modify solubility or taste using: Salt Polymorph Cocrystal Prodrug For more information on taste masking and why Adare is considered the world leader in coacervation, review our related resources and speak with one of our taste-masking experts today. RELATED RESOURCES PATIENT-CENTRIC SOLUTIONS Overview Taste Masking Customized Release Bioavailability Enhancement LATEST NEWS EVENTS Our global manufacturing sites meet all cGMP standards, and are optimized for the development and production of specialized oral-dose and injectable delivery systems. And through our in-house regulatory affairs team, Adare can take your product from molecule to market, quickly and efficiently. — Giovanni Ortenzi, Pharmaceutical Development & Chief Technical Officer Speak With An Expert Luigi Boltri Director, Technology Development Dr. Boltri is a pharmaceutical chemist by training and completed his degree at the University of Turin. With almost 30 years of experience in the Pharmaceutical Industry, Dr Boltri has held leading positions as Department Head and Director. He has extensive formulation development experience in various dosage forms, with a focus on oral delivery and bioavailability enhancement. Dr. Boltri has overseen the development of 15 original/innovative products from prototype profiling to commercial scale. In his current role, Dr. Boltri supports company processes leading to identify new and innovative technologies, as well as valuable opportunities for product development and co-development. Contact Me What question can I answer for you? LET ME KNOW HOW WE CAN HELP* Please be specific FIRST NAME* LAST NAME* COMPANY* EMAIL* PHONE* COUNTRY* Select country... 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