All women deserve the right to NIPT. We intend to make it possible to serve their needs. VANADIS DIAGNOSTICS ACQUIRED BY PERKINELMER Read more All pregnant women deserve the right to reliable prenatal testing. But until now, screening for trisomies has been limited by the complexity, cost and capacity of existing NIPT technologies. Now, due to a breakthrough in advanced genetic analytics, we are developing a solution designed to make it simpler for any laboratory to provide high-precision NIPT with a fully automated platform. Vanadis Smart NIPT will be the first non-invasive prenatal testing platform designed to simplify screening for trisomies 21, 18 and 13 by eliminating the need for complex DNA amplification and analysis. The result will be a complete NIPT platform that any diagnostic lab can install, operate and connect with their existing LIMS system.

Separate the needle from the haystack Current sequencing methods, designed to sequence the whole genome, are simply over-dimensioned for the task of prenatal screening. Even in targeted sequencing, unnecessarily large volumes of genetic data that are irrelevant for aneuoploidy screening must be sequenced and counted. Vanadis Smart NIPT converts only the targeted chromosome regions to fluorescent DNA objects, which are then directly quantified on a microtiter plate scanner. Vanadis Smart NIPT technology cfDNA is extracted from maternal plasma. Thousands of targeted cfDNA fragments are captured and converted to DNA circles. Rolling circle amplification products are labeled with chromosome specific fluorophores. The labeled objects are individually counted using a microtiter plate based scanner. The Vanadis system is in development. Say goodbye to big data Unlike the DNA sequencing methods of other NIPT platforms, Vanadis Smart NIPT is designed to achieve the same results without using complex genetic data. Its ability to count only the right chromosome targets with very high precision and specificity means that the vast majority of irrelevant chromosomal data no longer needs to be generated. Train staff in days, not months Laboratory staff will be able to be trained to operate the Vanadis system in a matter of days, rather than the months of specialized training associated with comparable sequencing-based platforms. Individual samples and reagents are tracked with barcode scanners. And the entire automated process – from primary blood tube to result – will be completed in just 3-4 days. This substantially simplified testing process will make Vanadis Smart NIPT ideally suited to low-complexity laboratory environments. Follow us to learn more Vanadis Smart NIPT has gone through investigational studies during development with positive results. To receive updates on current clinical studies, an upcoming clinical white paper or to learn more about product release dates in your region, register here. The Vanadis system is in development

CONTACT INFORMATION Our office is located 10 minutes away from Stockholm city centre and 20 minutes from Arlanda airport at: Vetenskapsvägen 10 19138, Sollentuna Sweden You can reach us by email at info@smartnipt.com