Find a product for my lab Devyser AZF v2 Detect all markers needed for basic AZF deletion screening One tube per sample means no need for sample splitting Conforms to EAA and EMQN best practice guidelines View product Devyser AZF Extension Detects all markers needed for extended AZF deletion detection One tube per sample means no need for sample splitting Automatic identification of STS markers using capillary electrophoresis View product Devyser Resolution XY Rapid aneuploidy analysis of chromosomes X and Y Requires minimal amounts of genomic DNA Results in less than five hours View product Devyser AZF For best-practice compliance please see new products: AZF v2 AZF Extension View product Male infertility PCR analysis of Y-chromosome micro deletions is now standard practice in many infertility centers. Analysis of the Y chromosome in men with azoospermia or severe oligozoospermia has resulted in the identification of three regions in the euchromatic part of the long arm of the human Y chromosome (Yq11) that are frequently deleted in men with otherwise unexplained spermatogenic failure. PCR analysis of micro deletions in the AZFa, AZFb and AZFc (AZF: Azoospermia Factor) regions of the human Y chromosome is an important screening tool in the work-up of infertile males opting for assisted reproductive techniques. Y chromosome micro deletions are the most common genetic cause of male infertility and screening for these micro deletions in azoospermic or severely oligospermic men is now standard practice in many infertility centers. Diagnostic testing using the Devyser AZF kits relies on PCR amplification of sequence-tagged sites (STS) in the AZFa, AZFb and AZFc regions on the Y-chromosome followed by analysis by capillary electrophoresis. Successful amplification of an STS marker indicates presence, whereas absence of PCR amplification is indicative of deletion. Devyser’s unique single-tube approach simplifies the workflow, reduces hands-on time and minimizes the risk of sample mix-up and contamination during both basic and extended AZF analysis. Scientific publications A different look at genetic factors in individuals with non-obstructive azoospermia or oligospermia in our research study: To whom, which threshold, when, in what way?, E. Gumus et al., Revista Internacional de Andrología, Volume19, Issue 1, January–March 2021, Pages 41-48. Analysis of Y-chromosomal microdeletions in an azoospermic patient candidate for an assisted reproductive technique. M. Rongioletti et al., American Journal of Clinical Pathology, Volume 142, Issue suppl_1, October 2014, Page A190. ‍EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: state-of-the-art 2013. Krausz, C. et al., Andrology. 2014 Jan;2(1):5-19.‍ Analysis of the AZF region in slovak men with azoospermia. J.Bernasovská et al., International Journal of Medical, Medicine and Health Sciences: 7.0 (9); 2014. Results for life. Product categories Transplantation Thalassemias Oncology Fetal RHD screening NIPT Hereditary Cystic fibrosis Cardiovascular Male infertility Rapid aneuploidy analysis Accessories Resources Knowledge hub Whitepapers Tools IFU & certificates Company About us Teams Career News and events Privacy policy About cookies Contact Contact us Our offices Support Distributors © Devyser 2021