Diseases Helpful information For specialists about the project 8-800-333-24-71 Composition of the preparation Clinical researches Mechanism of action Osteoarthritis treatment Treatment of osteochondrosis Instructions For specialists Alflutop is a chondroprotector , the active component of which is a bioactive concentrate from small sea fish, containing chondroitin-4 and 6-sulfate in the correct ratio for cartilage, dermatan sulfate, keratan sulfate, glucuronic acid (a precursor for the synthesis of hyaluronic acid), amino acids, myophosphates-inosipidol , macro and micro elements. COMPOSITION OF THE PREPARATION ALFLUTOP ACTIVE SUBSTANCES EXCIPIENTS The excipients that make up Alflutop correspond to the Russian XIII State Pharmacopoeia, which is harmonized with the requirements of leading foreign pharmacopoeias and fully complies with the current level of development of the pharmaceutical industry: - phenol (max 0.005 g), - water for injection (up to 1 ml) In order to suppress extraneous microflora during the production and storage of certain drugs, immunobiological drugs, thiomersal, phenol and formaldehyde are most often used as preservatives. These preservatives are part of a number of vaccines (bacterial and viral), toxoids, allergens, etc. 1 In addition, Phenol is contained in vaccines - inactivated cholera; leptospirosis, inactivated; typhoid Vi-polysaccharide; dysentery against Shigella Sonne. Phenol is a part of some insulins (Humulin®, Humalog®, Victoza®, Levemir® FlexPen®, NovoMix® 30, NovoRapid®, Tresiba®, etc.); preparations of hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists (Omnitrop®, Norditropin® NordiLet®); immunomodulators (Ruzam®). According to toxicological studies carried out in accordance with the provisions of the current European legislation, the product Alflutop - solution for injection is non-toxic when administered in a single dose and does not cause toxic changes after 120 days of application of doses that exceed 20 times the therapeutic dose: — Для фенола ЛД(летальная доза)50 = 70 мг/кг веса тела (т.е. для взрослого человека весом в 70 кг ЛД50 составляет 4,9 г фенола)2 — В Алфлутопе при введении терапевтической дозы/день/взрослого, фенол находится в количестве максимум 4 мг при введении 1 мл и соответственно 8 мг при введении 2 мл , доза, которая приблизительно в 1200 раз меньше, чем ЛД50 = 4,9 г/взрослого весом в 70 кг при введении 1мл/день и ~ в 600 раз ниже при введении 2 мл/день — Согласно фармакокинетическим данным период полувыведения фенола из человеческого организма составляет около 3,5 часов.2 1. EUROPEAN PHARMACOPOEIA - 8th EDITION, p 1987|2133 2. Evidence on the developmental and reproductive toxicity of Phenol DRAFT», 07/ 2003 г Ответим на Ваши вопросы ASK A QUESTION THE INFORMATION CONTAINED ON THE SITE IS NOT A SUBSTITUTE FOR CONSULTING A DOCTOR © 2010-2017 Feedback Helpful information For specialists about the project Pharmacovigilance