Home About Services Drug Discovery News Careers Contact Standard Microdialysis Technique PsychoGenics offers analyses of a variety of neurotransmitters in the extracellular spaces of rodent brain via microdialysis. When combined with sensitive bioanalytical techniques, microdialysis provides the most comprehensive information on dynamic changes in the concentration of molecules involved in intercellular communication and metabolism in awake, freely moving animals. The method can be used in naïve and genetically modified animals. We have developed methods to measure acetylcholine, choline, histamine, amino acids (such as glutamate, GABA, serine and cysteine), and monoamines (dopamine, noradrenaline, serotonin and their metabolites). Dopamine Measures Figure 1: A ketamine dose-response study on extracellular dopamine levels in microdialysates collected from striatum of freely moving rats clearly demonstrates the impact of Ketamine on dopamine levels in the striatum. Sprague Dawley rats, male, 250-300g, n=10/group. Acetylcholine Measures Figure 2: Acute vortioxetine effects on extracellular acetylcholine concentrations in the ventral hippocampus. Acute 10 mg/kg vortioxetine treatment induced a transient and relatively small, but significant increase in hippocampal extracellular Ach compared with vehicle control animals. Alan L. Pehrson, Todd M. Hillhouse, Nasser Haddjeri, Renaud Rovera, Joseph H. Porter, Arne Mørk, Gennady Smagin, Dekun Song, David Budac, Manuel Cajina and Connie Sanchez. Task- and Treatment Length–Dependent Effects of Vortioxetine on Scopolamine-Induced Cognitive Dysfunction and Hippocampal Extracellular Acetylcholine in Rats. Journal of Pharmacology and Experimental Therapeutics September 2016, 358 (3) 472-482. Want to get in touch? Connect with the PsychoGenics research team. Connect With Us CONTACT PsychoGenics Inc. 215 College Road, Paramus, NJ 07652 Email: info@psychogenics.com Phone: (914) 406-8019 Fax: (914) 406-8090 Privacy Policy Terms of Use Financial Conflict of Interest Policy Copyright ©2021 PsychoGenics Inc. All rights reserved. We are using cookies to give you the best experience on our website. You can find out more about which cookies we are using or switch them off in settings. Accept