PPD Inc Main Menu Have a question? Contact us today! BIOANALYTICAL LAB CAPABILITIES Our Solutions PPD Laboratories Bioanalytical Lab BioA Capabilities CELL-BASED ASSAYS PPD® Laboratories’ bioanalytical lab has been providing cell-based assays services since 2007. We have a dedicated team of research scientists experienced in cell culture technologies, cell-based assay development and validation, cell-line engineering, microbiology, virology and molecular biology. The bioanalytical lab’s cell-based assay experience involves the transfer of more than 80 cell-based assays across a wide range of applications including: Drug-specific NAb assays (including biosimilars) Biomarkers Toxin neutralization assay (TNA) Virus-specific NAb assays Our service offering includes: Comprehensive assay transfer capabilities CLIA validation of NAb assays Sample analysis for studies in excess of 1,500 samples Various end points for early events, for example receptor phosphorylation (ECL), cellular proliferation (cATP, cAMP) and cell signaling pathways (STAT3,SMAD) Numerous end points for late events consisting of cytokine production/detection and reporter gene products (fluorescence) Key instrumentation: MSD® Sector® S 600 reader BioTek Cytation™ reader Beckman Coulter Vi-CELL™ analyzer Biosafety cabinets CO2 incubators In addition to supporting bioanalytical studies for various types of pharmaceuticals, cell-based assays are an integral part of vaccine development. Explore Capabilities CELL-BASED ASSAYS CHROMATOGRAPHY/MASS SPECTROMETRY FLOW CYTOMETRY IMMUNOCHEMISTRY MOLECULAR GENOMICS LEARN MORE ABOUT PPD® LABORATORIES’ VACCINE DEVELOPMENT CAPABILITIES LEARN MORE ABOUT PPD LABORATORIES’ BIOLOGICS EXPERIENCE LEARN MORE ABOUT PPD LABORATORIES’ SMALL MOLECULE EXPERIENCE CHROMATOGRAPHY/MASS SPECTROMETRY PPD Laboratories bioanalytical lab offers substantial capacity and expertise in the increasingly sophisticated field of chromatography. We have applied LC-MS/MS to compounds that range from small molecules to antibody-drug conjugates (ADCs) with measurement in biological fluids and tissues. We utilize the most advanced automated sample cleanup techniques for rapid sample analysis and employ stable isotope internal standards for highly precise quantitation. Our extensive scientific and technical expertise includes: Highly diverse range of analytes from small molecules to complex biologics Difficult endogenous, reactive or unstable analytes Ultrahigh sensitivity assays with sub-pg/ml lower limits of quantification (LLOQ) High-resolution mass spectrometry Key instrumentation: Hamilton® MICROLAB® STARlet automatic pipetting workstation Sciex Triple Quad™ 6500 Sciex Q-Traps Shimadzu Nexera UHPLC systems with 2-D capabilities Thermo Scientific™ Q Exactive™ Plus (HRMS) Thermo Scientific™ Aria® multiplexing systems Waters Xevo® G2 QTof (HRMS) Waters Acquity UHPLC systems with 2-D capabilities FLOW CYTOMETRY PPD Laboratories’ flow cytometry assays integrate into our bioanalytical and central labs. This integration provides flexibility to leverage our operational and organizational structures for a tiered regulatory approach to meet customers’ needs. From fit-for-purpose assays to projects that require GCLP-, GLP- or CLIA-compliant assays, we have the technology platforms, the clinical expertise and the collaborative and flexible mindset needed to develop customized solutions for our customers. We have a dedicated team of scientists at the bioanalytical lab and many cross-trained scientists across the various central lab locations. Research and development for flow cytometry assays is performed in our Richmond, Virginia, location, where our scientists have more than 25 years of combined experience. Our service offering includes: Assay development and validation under CAP/CLIA, GLP and/or GCLP regulations Enumeration of cells (4-, 6- and 8-color) Routine cell surface antigen expression Intracellular cytokine assays Platelet, neutrophil and basophil activation assays Receptor occupancy Complex phospho-flow assays Peripheral mononuclear cell (PBMC) enumeration and intracellular cytokine assays Training to clinical sites for complex procedures, such as phosph-flow and activation assay Key instrumentation: BD FACSCanto™ II flow cytometers In addition to supporting bioanalytical studies for various types of pharmaceuticals, flow assays are an integral part of biomarker development. LEARN MORE ABOUT PPD LABORATORIES’ BIOMARKER DEVELOPMENT CAPABILITIES LEARN MORE ABOUT PPD LABORATORIES’ BIOSIMILAR EXPERIENCE IMMUNOCHEMISTRY PPD Laboratories’ bioanalytical lab offers comprehensive immunochemistry services to support pharmacokinetic (PK) and anti-drug antibody (ADA) safety assessments. We have broad biopharmaceutical experience with a variety of molecules, including monoclonal and multivalent antibodies, antibody fragments, oligonucleotides, PEGylated proteins and antibody drug conjugates (ADCs). Our service offering includes: PK/PD ligand-binding methods Immunogenicity/ADA assays Oligomer/aptamer methods 40 plate-based neutralizing antibody assays Quantitation and validation of endogenous analytes Robotic liquid handling to support high-volume testing needs and improve precision and accuracy Automated immunogenicity screening Key instrumentation/platforms: TECAN EVO® automated liquid-handling workstations ELISA Meso Scale Discovery® (MSD®) Technology Gyros Gyrolab™ xP workstation Fluorescence and radioimmunoassays MOLECULAR GENOMICS PPD Laboratories has a custom-built, spacious, leading-edge molecular genomics suite staffed with a dedicated team of molecular biologists. The suite of labs is designed with the appropriate engineering and procedural controls to minimize the risk of reagent and sample contamination. Our capabilities include assay development, qualification, validation and sample analysis services in the following areas: Viral detection, quantification and typing (PCR-based) Bacterial detection, quantification and typing (PCR-based) SNP detection Copy number variation Gene sequencing Gene expression Vector (transgene) copy number Vector (transgene) persistence Epigenetics Key instrumentation: Agilent Mx3005P qPCR System Agilent TapeStation 2200 Bioanalyzer Applied Biosystems® 3730xl Genetic Analyzer Applied Biosystems 7500 Applied Biosystems QuantStudio 6 BioMérieux NucliSENS® easyMag® nucleic acid extraction system BioRad Gel Doc XR+ Imaging System BioRad QX200 Droplet Digital PCR (ddPCR™) System Illumina® MiSeq (NextGen sequencer) Qiagen BioRobot Universal System Qiagen QIAsymphony® SP nucleic acid extraction system TECAN EVO® automated liquid-handling LEARN MORE ABOUT PPD LABORATORIES’ BIOMARKER CAPABILITIES LEARN MORE ABOUT THE EXPERIENCE AND EXPERTISE OF OUR BIOANALYTICAL LAB MOLECULAR GENOMICS VIRTUAL TOUR THE VIDEO CLOUD VIDEO WAS NOT FOUND. Error Code: VIDEO_CLOUD_ERR_VIDEO_NOT_FOUND Session ID: 2021-11-25:b119b5c8455fc7d9f47affff Player ID: vjs_video_3 OK Close Modal Dialog PPD LABORATORIES' BIOANALYTICAL LAB THOUGHT LEADERSHIP SERIES Watch as experts from our bioanalytical, biomarker and vaccine sciences labs in Richmond, Va., take you through trending topics of the bioanalytical landscape ranging from CAR-T cell enumeration to vaccine immunogenicity testing. WATCH THE VIDEOS RELATED RESOURCES Learn more about PPD Laboratories’ bioanalytical lab Bioanalytical Lab Capabilities Explore our comprehensive services for both small molecules and biologics. DOWNLOAD Validated Assay List PPD Laboratories bioanalytical lab has experience across a wide range of molecules and has an extensive collection of validated assays. DOWNLOAD Contact PPD Laboratories’ Bioanalytical Lab Request a quote or more information about our capabilities and services. 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