IVCC Read about our... INTRODUCTION LITE’S WORK PUBLICATIONS Liverpool Insect Testing Establishment (LITE) READ TIME 2 MINUTES #IRM #IVM #MALARIA Liverpool Insect Testing Establishment (LITE) provides a professional testing service to commercial partners to accelerate the development of new public health insecticides and vector control tools. Established by the Liverpool School of Tropical Medicine (LSTM) and funded by IVCC, LITE employs a team of research technicians, study directors, research assistants and quality assurance specialists. LITE’s goal is to be a world leader in providing quality services that help improve the health of millions of people across the globe, by providing protection against malaria and other vector-borne diseases. Housed in state-of-the-art and purpose-built facilities in the Liverpool Life Sciences Accelerator Building LITE maintains a wide range of fully characterised mosquito strains, selected to incorporate the key resistance mechanisms circulating in field populations, maintained under stringent conditions to ensure consistency between tests. LITE’s Work LITE’s insecticide resistance data is supported by rigorous quality control on the mosquito colonies. Resistant colonies are challenged with insecticide on a regular basis and the resistance profile of each colony is being determined for several different insecticides. A subset of mosquitoes are preserved for genotyping to test for target site mutations every 5th generation and metabolic resistance and other mechanisms are being explored using a range of techniques, including microarray and functional analysis. LITE has been undertaking an increasing number of studies to understand the entomological mode of action of newer vector control products and insecticides. This has included studies on factors affecting mosquito’s ability to feed on Attractive Targeted Sugar Baits (ATSB® ) and studies on how the physical properties of insecticides on a surface affects their biological activity. LITE is also contributing to the World Health Organization’s (WHO) multi-site study to define ‘diagnostic doses’ for new insecticide classes used in public health. Publications During 2019 LITE published two important papers to help clients select the most appropriate mosquito strain and test assay. The first describes the testing pipeline employed for evaluating agricultural insecticides to assess their suitability for use in future mosquito control products. The second describes the properties of the resistant strains maintained in LITE, describing their resistance phenotypes and the underpinning resistance mechanisms. Characterisation of Anopheles strains used for laboratory screening of new vector control products A comprehensive testing cascade to identify resistance breaking repurposed insecticides for next-generation vector control tools: screening a panel of chemistries against a malaria vector Related #IRM #IVM #MALARIA #NTDS LITE Has a New Website LITE has launched a new website. LITE was established by LSTM and funded by IVCC. Read More > #IRM #MALARIA Insecticide Resistance Management (IRM) #IVM #MALARIA #NTDS Integrated Vector Management (IVM) #NOVEL AI #LLIN #IRS #IRM Chemical Analysis #NOVEL AI #IRM Insecticide Discovery & Development #IRM #IVM #MALARIA African Trials Facilities Sign up to receive the IVCC Newsletter Home Vacancies Contact Us Disclaimer Privacy Sitemap Modern Slavery Statement Web Accessibility Statement +44 151 705 3268 info@ivcc.com © 2021 IVCC Created by Rowan Marketing IVCC is a company registered in England and Wales with Company No.06719882. Registered office address is Liverpool School Of Tropical Medicine, Pembroke Place, Liverpool, Merseyside, L3 5QA.