Innovative Drug Delivery Optimizing delivery based on drug properties and clinical need Changing the way drugs are developed and delivered can have a positive impact for patients and caregivers. Aquestive Therapeutics is the primary innovator and worldwide leader in developing medicines on oral films to maximize their usability. Independently and with partners, our quest is to leverage our highly customizable PharmFilm® technology to solve therapeutic problems and meaningfully improve the lives of people who face barriers to using important medications. PharmFilm® is a unique and versatile technology for high-performance drug delivery. Aquestive scientists combine the customizable features of PharmFilm® with patented formulation and engineering processes to optimize the delivery of active pharmaceutical ingredients (APIs). PharmFilm® technology provides the development platform for our expanding pipeline of proprietary and partner-developed products. PharmFilm® Drug Differentiation by Design Aquestive’s Commitment to Improving Lives Through PharmFilm® Technology Take your API further Partner with Aquestive Delivery Methods Science Advantages Request a demo kit Optimize the administration route Sublingual, lingual, or buccal drug delivery gives patients with complex dosing challenges a simple, non-invasive, and more convenient way to dose. No mixing, swallowing, or chewing.1 The degree of mucosal permeability and desired product profile are used to determine the targeted route of delivery. In this way, Aquestive’s Development Services team can tailor treatments to optimize a drug’s pharmacokinetic profile and meet the requirements of specific patient populations. Buccal Controlled release and engineered retention time in a controlled microenvironment Sublingual Rapid onset of action with direct entry into systemic circulation Lingual Rapid disintegration and controlled release with bioequivalancy to tablets and capsules The science behind PharmFilm® technology How does PharmFilm® work? Polymers are used as film formers to hold the API and excipients in place. Patented techniques are used to ensure that the API is uniformly distributed throughout the film. Aquestive utilizes the proprietary features of PharmFilm® technology along with a wide array of solvents, pH modifiers, and permeation enhancers to achieve target absorption, bioavailability, and onset of action. Kinetics: Tmax and Cmax Oral cavity absorption Redesigning medicines for optimal product usability Every medicine is different, so Aquestive follows a drug-by-drug approach for harnessing film technology to achieve target product profiles and clinical improvement goals. Customized to the chemical structure of the API, the Formulation Engineering team leverages proprietary PharmFilm® technologies, pH modifiers, and permeation enhancers to achieve target absorption. Formulating products for high-performance drug delivery Customized film designs maximize transcellular and intercellular transport across the mucosa Expertise in applying pH modifiers and permeation enhancers for targeted absorption Custom Film Formulation and Engineering Expert scientists tailor blends of polymers, prodrugs, and excipients to optimize drug release and bioavailability The compositional profile of the custom formulation is used to establish the optimal rate of dissolution Unique polymer blends hold the API and excipients in place, preserving the original structure Patented techniques are applied to ensure uniform distribution Customizable Features Adaptable polymer matrix Array of FDA-approved permeation enhancers Variety of flavors Range of drug loads Potential PharmFilm® advantages 3 possible routes of administration (based on API) Optimized absorption and onset of action Reduced drug exposure Easy, convenient dosing VS Commercial partners Trust in a global leader with a proven history of bringing novel drugs successfully to market Physicians A proven option for delivering important medicines in accurate doses to patients Patients Access to important medications that are simple to dose, where you need it, when you need it™ Learn more about PharmFilm® Visit pharmfilmeducation.com Contact the Aquestive business development team at busdev@aquestive.com Reference 1. Slavkova M, Breitkreutz J. Orodispersible drug formulations for children and elderly. Eur J Pharm Sci. 2015;(75):2-9. Contact Us About Us Our Medicines Pipeline Innovative Drug Delivery Collaborations Investors Careers Newsroom Images of individuals were purchased by Aquestive® Therapeutics and are intended to model real patient scenarios. © 2020 Aquestive Therapeutics, Inc. PharmFilm®, Sympazan®, and the Aquestive logo are registered trademarks of Aquestive Therapeutics, Inc. All rights reserved. Terms of Use Privacy Policy Corporate Governance Code of Conduct California Compliance Declaration California Consumer Privacy Policy Sitemap This site uses cookies to store information on your computer. Some are essential to make our site work; others help us improve the user experience. By using the site, you consent to the placement of these cookies. OkLearn More