OPKO Health, Inc. Our Products WHAT WE DO VIEW PRESCRIBING INFORMATION LEARN MORE 4Kscore® Test The 4Kscore® Test is used by health care professionals to improve the accuracy of prostate cancer diagnosis after an abnormal prostate-specific antigen (PSA) test result, or digital rectal exam, before the decision is made to biopsy. The 4Kscore® Test provides a risk score (4KScore) for finding aggressive prostate cancer based on combined serum concentrations of four prostate specific kallikrein proteins, and a subject’s clinical information, using a validated, proprietary algorithm. The 4Kscore® Test has been well studied, and published data have shown the stratification of men with elevated PSA and high 4Kscore to relative long term risk for prostate cancer, mortality, or prostate cancer metastasis 15-20 years out. The 4Kscore® Test has been demonstrated in prospective controlled clinical trials to have 95% sensitivity and 93% negative predictive value for aggressive prostate cancer prior to prostate biopsy with reduction in un-necessary prostate biopsies by 26-38%. This test is offered by OPKO’s own clinical laboratories as Laboratory Developed Test (LDT). LEARN MORE Patents VIEW PATENTS © 2021 OPKO Health, Inc. All Rights Reserved. PRIVACY POLICY GOVERNANCE TERMS OF USE SITEMAP

OPKO Health, Inc. What We Do WHAT WE DO Our Products •• LEARN MORE Our Solutions We have a variety of biomedical and pharmaceutical business solutions to meet the needs of patients, healthcare professionals and researchers alike. OUR SOLUTIONS Our Technology We utilize our proprietary technology to create cutting edge therapeutics designed to meet ever-evolving patient needs. OUR TECHNOLOGY Our Research With a strong research and development pipeline, OPKO continues to develop and produce industry-leading pharmaceutical products. OUR RESEARCH Our Diagnostics BioReference Laboratories is one of the largest full-service clinical diagnostics laboratories in the U.S. OUR DIAGNOSTICS © 2021 OPKO Health, Inc. All Rights Reserved. PRIVACY POLICY GOVERNANCE TERMS OF USE SITEMAP

OPKO Health, Inc. Events NEWS & MEDIA Upcoming Events There are no upcoming events scheduled at this time. Sign up here to receive notices about upcoming events and press releases. Past Events Piper Sandler 33rd Annual Virtual Healthcare Conference Dec 1, 2021 ASN Kidney Week 2021 Annual Meeting Nov 4 – Nov 7, 2021 Q3 2021 Financial Results Conference Call Oct 28, 2021 • 4:30 pm EST H.C. Wainwright 23rd Annual Global Investment Conference Sep 13 – Sep 15, 2021 14th Annual Barrington Research Fall Conference Sep 9, 2021 Q2 2021 Financial Results Conference Call Jul 29, 2021 • 4:30 pm EST Ladenburg Thalmann Healthcare Conference Jul 13 8:30 am EST – Jul 14, 2021 2021 Annual Meeting of Stockholders Jun 24, 2021 • 10:00 am EST VIEW ALL PAST EVENTS © 2021 OPKO Health, Inc. All Rights Reserved. PRIVACY POLICY GOVERNANCE TERMS OF USE SITEMAP