Products Area of Interest Resources Support Company Careers Oncology Resolve Cancer with single cell and spatial multiomics Overview Customer Research Resources Publications Products Download brochure Gain a multidimensional view of cancer Address the true complexities of cancer with sharper resolution into the cell types and states that drive cancer. 10x Genomics develops technologies that illuminate the details and dynamics of this complicated disease. Dissect the tumor and immune contexture See how the combination of single cell gene expression and spatial profiling technologies enables researchers to explore tumor heterogeneity and the complex interactions of the tumor microenvironment (TME). Tumor Heterogeneity Build integrated single cell and spatial atlases, unmask intratumoral heterogeneity, and trace transcriptomic and epigenetic modulators of clonal evolution within tumors and across cancer types. Tumor Microenvironment Uncover the influence of tissue architecture on cancer progression, immune infiltration, and therapeutic response and identify the epigenetic regulators and transcriptomic programs driving diverse phenotypes and developmental trajectories. Immuno-oncology Advance immunotherapies by characterizing immune cell modulation in tumor progression. Define the receptor repertoire of infiltrating and peripheral immune cells mediating anti-tumor responses. Therapeutic Development Discover novel therapeutic targets, explore how therapeutics modulate cell populations and states within the tumor microenvironment, and understand resistance mechanisms governed by transcriptomic and epigenetic remodeling. Customer Research Visualize Cancer in Multiple Dimensions Researchers at the Fred Hutchinson Cancer Research Center are using multidimensional single cell analysis to peer deeper into the tumor microenvironment. These technologies are helping them investigate the body’s response to tumors, discover key driver mutations, and inform why treatments fail. View Video View Publication Explore featured resources to enhance your oncology research Sample Prep Guide Get the most out of your single cell experiments with this essential guide, filled with best practices and useful resources to help you optimize your sample prep. Download Sample Prep Guide Application Note Learn how Visium for FFPE complemented pathological assessment of tumor microenvironments with spatial gene expression insights for key prostate cancer markers and cell types. Download App Note View All Application Notes Poster See how spatial gene expression profiling can provide a powerful complement to traditional histopathology, enabling a detailed view of the tumor microenvironment architecture. View Poster View All Posters Publications Unraveling cancer complexities Single cell and spatial tools from 10x Genomics enable cancer researchers to ask and answer deeper questions. See how researchers are using these tools to fundamentally alter our understanding of cancer and accelerate novel translational applications in diagnosis, prognosis, therapeutic development, and treatment. Download Cancer Research Highlights Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas Nature Biotechnology, Jan 2020 Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion Nature Biotechnology, Aug 2018 Increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer Nature Cancer. 2020, C. Allison Stewart, et al. Products for Oncology Research Single Cell Gene Expression Profile cell types and states with 3' gene expression, surface protein expression, and CRISPR perturbations in the same cell. Identify novel and rare cell types and states associated with tumor biology. Leverage large-scale CRISPR screens to discover new therapeutic targets. More info Spatial Gene Expression Spatially profile gene expression with morphological context in intact FFPE or fresh frozen tissue sections. Refine pathological annotation and explore tumor heterogeneity. Gain insights into the spatial architecture driving the complex cellular networks underlying cancer biology. More info Single Cell Immune Profiling Analyze full length paired BCRs/TCRs, surface protein expression, antigen specificity, and 5' gene expression in the same cell. Explore immune clone expansion and cellular phenotypes in the TME Understand how therapeutic interventions shape immune cell clonality More info Single Cell Multiome ATAC + Gene Expression Explore combined gene expression and chromatin accessibility data from the same cell to uncover gene regulatory programs. Deeply characterize immune cell states, uncover gene regulatory programs driving immune cell lineage and differentiation. Identify target genes and cell types of genetic variants associated with immune-mediated disease. More info Resolve cancer with single cell and spatial multiomic products from 10x Genomics View Products Contact Us ABOUT Products Platform Company Careers Contact Employment Verification LEGAL NOTICES Privacy Policy Terms of Use Email Preferences Other Legal Notices HEADQUARTERS +1 925 401 7300 +1 800 709 1208 info@10xgenomics.com RESOURCES Publications Support Videos SOCIAL SIGN UP FOR PRODUCT AND EVENT UPDATES Subscribe © 2021 10x Genomics. All Rights Reserved. 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