CAPABILITIES CATALOG NEWS AND PUBLICATIONS ABOUT CONTACT US LIVER & HEPATIC SYSTEM Porsolt’s experience in preclinical safety and efficacy has led to the development of models that focus on the liver and hepatic system. This is an important part of the process to better understand the effects of compounds on the liver and hepatic system. LIVER & HEPATIC CAPABILITIES SCROLL LIVER & HEPATIC SYSTEM IN VITRO MODELS Acetaminophen (acute model) Mouse Cholestasis/Bile canaliculi network Primary hepatocytes sandwich configuration, Rat Glutathione (GSH), intracellular GSH content Primary human and rat hepatocytes Steatosis/Lipid, intracellular accumulation: neutral lipids Primary human and rat hepatocytes Cytolysis Primary human and rat hepatocytes Lipid, intracellular accumulation: phospholipids Primary human and rat hepatocytes 3D Hepatotoxicity (Viability) Primary human hepatocyte spheroids IN VIVO MODELS Acetaminophen (acute model) Mouse Bile Duct Ligation (BDL) (chronic model) Rat Carbon tetrachloride (CCl4) (acute model) Rat LIVER & HEPATIC SYSTEM PUBLICATIONS BIOMARKER ASSAYS Porsolt Z.A. de Glatigné 53940 Le Genest-Saint-Isle, France Telephone +33 2 43 69 36 07 LinkedIn Legal Notice Any questions or concerns ? CONTACT US © COPYRIGHT - PORSOLT 2021

CAPABILITIES CATALOG NEWS AND PUBLICATIONS ABOUT CONTACT US GASTRO-INTESTINAL SYSTEM Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models. GASTRO-INTESTINAL CAPABILITIES SCROLL GASTRO-INTESTINAL DISEASE Colonic Motility Emesis - Nausea Food Allergy Gastric Emptying Gastro-intestinal Transit Gastroparesis Intestinal Mucositis Ulcerogenic Activity Visceral Smooth Muscle GASTRO-INTESTINAL PUBLICATIONS BIOMARKER ASSAYS Porsolt Z.A. de Glatigné 53940 Le Genest-Saint-Isle, France Telephone +33 2 43 69 36 07 LinkedIn Legal Notice Any questions or concerns ? CONTACT US © COPYRIGHT - PORSOLT 2021