Gene Editing Gene editing will completely reshape molecular medicine within five years and it has already started. The principle of gene editing is very simple: in the same way that spell check identifies and corrects errors in a word or grammar errors in a sentence, gene editing can be used to precisely edit or change the genetic code within an individual’s DNA. Gene editing has many potential therapeutic applications. For example, it can be used to correct diseases and disorders that have a genetic basis. Just as editing text involves adding, removing, or replacing words, genome editing is an approach in which the genome sequence is directly changed by adding, replacing, or removing DNA bases. Gene editing is going to change the way people are treated by curing the roots of diseases instead of merely treating the symptoms. It provides us with the ability to rethink how we treat diseases altogether. It is the next transformative step in medicine. There are three possible strategies to do this: Gene insertion Insertion is used to add a new function to the genome. For example in drug discovery, or in order to overcome a genetic defect like hemophilia. Gene correction Correction is used to replace an existing defective sequence (which generally impacts the gene’s functions) with a functional sequence. For example, to treat a serious genetic disease such as cystic fibrosis. Gene inactivation Inactivation is used to prevent the expression of a gene. This approach can be used to treat persistent viral infections such as AIDS. TALEN® This ultra-precise gene-editing technology makes it possible to precisely edit the genome of any organism. LEARN MORE PulseAgile See how we use PulseAgile to introduce nucleases inside the target T-cell where they can access the cell’s genomic DNA and how this technology will enable mass-production of affordable cancer therapies. LEARN MORE Vectorization Vectorization consists in combining a vector with an active substance to adapt and control it towards a target and ensure its efficient delivery. LEARN MORE LEGAL NOTICEGLOSSARYMEDIA LIBRARYCONTACTCOMMUNITY GUIDELINES Subsidiary: Calyxt Inc.