CONTACT: SALIMETRICS (USA) (800) 790-2258 SEARCH MY STUDY / QUOTE RESOURCES ANALYTES & DNA PRODUCTS & SERVICES HOW TO ORDER ABOUT US CONTACT MINERALOCORTICOID RECEPTOR – MR, NR3C2 Corticosteroid receptors are released into the brain by the adrenal cortex during stressful circumstances and when released, have been shown to affect mental processes like emotion and cognition (1). The mineralocorticoid receptor (MR) is one of two known corticosteroid receptors that has equal affinity for both mineralocorticoids and glucocorticoids. Read More... REQUEST ADVICE ADD TO STUDY GENE SUMMARY Gene: Mineralocorticoid Receptor Gene Symbol: MR,MLR, or MCR Also Known As: NR3C2 Related Analyte(s): Cortisol COMMON SNPS rs2070951 , rs149902988 , rs138068105 , rs199942132 ASSAY METHODOLOGY Genomic DNA, purified using silica based membrane columns is analyzed by TaqMan® SNP Genotyping Assays run on the 7900HT real time PCR system Yield: 2-5 ug genomic DNA TECHNICAL DOCUMENTATION Assessing genetic polymorphisms using DNA extracted from cells present in saliva samples. COLLECT SALIVA SAMPLES DNA SALIVA COLLECTION CONSIDERATIONS Better results begin with better saliva collection. This collection protocol features general considerations to maximize salivary DNA analysis. Use this collection protocol to plan your collection methodology and sampling schemes. Collection Protocol APPROVED SALIVARY DNA COLLECTION METHODS SalivaBio Passive Drool Method Adults, Children 6+ ADD TO STUDY SalivaBio Oral Swab (SOS) Method Adults, Children 6+ ADD TO STUDY SalivaBio Children's Swab (SCS) Method Animals, Children <6 years ADD TO STUDY TEST SALIVA SAMPLES @ Salimetrics Salimetrics SalivaLab - Easy & Accurate Order Code (lab): 5811 (SNP Genotyping) Transport Requirements: Ship on Dry Ice ADD TO STUDY ALL LAB SERVICES @ Your Own Lab Salimetrics Assay Kits - Better Results The validated method used by Salimetrics is proprietary and not available in assay kit form at this time. REFERENCES & MR RELATED RESEARCH Kellendonk, C. et al (2002). Corticosteroid receptors in the brain: gene targeting studies. Brain Research Bulletin. 57(1), 73-83 Rogerson, FM. et al (2003). Dissecting mineralocorticoid receptor structure and function. Journal of Steroid Biochemistry & Molecular Biology. 85(2-5), 389-396. Funder, JW. Et al (2005). Mineralocorticoid receptors: distribution and activation. Heart Failure Reviews. 10(1), 15-22 DeRijk, R. et al (2005). Corticosteroid receptor genetic polymorphisms and stress responsivity. Endocrine. 28(3), 263-270. Vinkers, CH. Et al (2015). Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment. Psychoneuroendocrinology. 54, 90-102. HOW TO GET STARTED CALL 800.790.2258 ASK AN EXPERT REQUEST A QUOTE SALIMETRICS, LLC. (800) 790-2258 support@salimetrics.com SUPPORT Tips and Advice Newsletter Archives Saliva Research News Workshops & Training ORDERING Request Quote Order Collection Supplies Submit Saliva Samples International Distributors Terms & Conditions of Sale PRODUCTS & SERVICES Saliva Collection Methods Saliva Lab Services Salivary Assay Kits CONTACT Map & Contact Info Request Advice Request A Workshop © 2021 | Salimetrics, LLC. NEW – Salivary Bioscience Webinars Learn the better methods for getting the most out of your Salivary Bioscience research study. CHECK AVAILABLE DATES CALL 800.790.2258 ASK AN EXPERT   REQUEST A QUOTE X Online Training