All Departments Home Shop Athletes About Manufacturing Contact 888-855-7919 customerservice@hitechpharma.com Your Order USD USD Register or Sign in 0 All Departments Protein Mass Weight Loss Muscle & Strength Testosterone Support Liver Support Find a Retailer Home Shop Athletes About Manufacturing Contact Free shipping on all orders over $99! Buy It Now Muscle & Strength Mass Protein FeaturedProduct Carnisport® Muscle Building Supplement $ 49.95 Already Sold: 1289 Hurry Up! Offer ends in: Muscle Building Supplement Androbolic 250™ SUPPLEMENT FACTS SUGGESTED USE As a dietary supplement, take 2 tablets once or twice daily on an empty stomach. Take 8-12 hours apart. Do... SUPPLEMENT FACTS SUGGESTED USE As a dietary supplement, take 2 tablets once or twice... SKU: APAND60 Availability: Temporarily Out of Stock Coming Soon Add to cart Quick View {"id":1693045825,"title":"Androbolic 250™","handle":"androbolic-250","description":"\u003cbr\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/andro250_large.png?1324308203357910403\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\nSUGGESTED USE\n\u003cp\u003eAs a dietary supplement, take 2 tablets once or twice daily on an empty stomach. Take 8-12 hours apart. Do not exceed 4 tablets per day.\u003c\/p\u003e","published_at":"2015-06-25T16:51:00-05:00","created_at":"2015-07-28T14:18:33-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":["Add Muscle","Muscle \u0026 Strength","Testosterone Support"],"price":7995,"price_min":7995,"price_max":7995,"available":false,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":5113234049,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APAND60","requires_shipping":true,"taxable":false,"featured_image":null,"available":false,"name":"Androbolic 250™","public_title":null,"options":["Default Title"],"price":7995,"weight":227,"compare_at_price":null,"inventory_quantity":0,"inventory_management":"shopify","inventory_policy":"deny","barcode":"649241899969"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/ANDROBOLIC250.jpg?v=1512488248"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/ANDROBOLIC250.jpg?v=1512488248","options":["Title"],"content":"\u003cbr\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/andro250_large.png?1324308203357910403\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\nSUGGESTED USE\n\u003cp\u003eAs a dietary supplement, take 2 tablets once or twice daily on an empty stomach. Take 8-12 hours apart. Do not exceed 4 tablets per day.\u003c\/p\u003e"} Muscle Building Supplement Arimigen™ DESCRIPTION Arimigen™ Supports Decrease of Estrogen & Increase of Testosterone Levels!* Arimigen™ — APS Nutrition's novel Aromatase Inhibitor is a new ground breaking formula designed... DESCRIPTION Arimigen™ Supports Decrease of Estrogen & Increase of Testosterone Levels!* Arimigen™ — APS Nutrition's... SKU: APARI60 Availability: Temporarily Out of Stock Coming Soon Add to cart Quick View {"id":1693157825,"title":"Arimigen™","handle":"arimigen","description":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eArimigen\u003c\/strong\u003e\u003cstrong\u003e™\u003c\/strong\u003e \u003cstrong\u003eSupports Decrease of Estrogen \u0026amp; Increase of Testosterone Levels!* \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eArimigen™ — APS Nutrition's novel Aromatase Inhibitor is a new ground breaking formula designed to optimize an anabolic environment by decreasing estrogen and increasing testosterone levels. Arimigen™ is a multi-pathway formulation that minimizes or eliminates the undesirable effects associated with an estrogen dominant environment. Arimigen™ maintains the correct testosterone to estrogen ratios that yield the benefits associated with normal estrogen levels. Arimigen™ acts as an anti-aromatase agent and is thus a powerful elevator of total testosterone and maximum liberator of free testosterone. This one-of-a- kind formulation is exclusively manufactured by APS and aggressively combats heightened estrogen levels that can come with elevated testosterone. *\u003c\/p\u003e\n\u003cbr\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/arimigen_large.png?10323656229900534673\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eArimigen™ allows the user to get the anabolic benefits of increased testosterone levels without the negative side-effects of estrogen (the downside of elevated testosterone), water retention and unattractive body-weight accumulation that usually accompany elevated levels of testosterone in the body. Arimigen™ is appropriately used when using substantial amounts of aromatizing hormones or prohormones. Arimigen™ also works by metabolizing active estrogens into inactive estrogen metabolites, blocking estrogen at the actual estrogen receptor site in male breast tissue, and by freeing excess estrogen from the body. Arimigen™ also will help to down regulate SHBG (Sex hormone-binding globulin) and therefore known to support increased FREE testosterone levels.\u003c\/p\u003e\n\u003cp\u003eThe Arimigen™ proprietary formula was developed by combining naturally occurring aromatase inhibitors and inhibitors of the action of SHBG. The dietary supplement Arimigen™ is a multi-pathway agent that exerts its influence by blocking various stages in the aromatase process and by inhibiting SHBG's action; an activity not clearly addressed by any of the aromatase inhibiting or anti-estrogen products. Further, it appears that use of Arimigen™ may result in long-term blocking of selective anabolic estrogen receptors and\/or inhibition of selective estrogen signaling. This activity has not been addressed by any known dietary supplements or pharmacological agents. \u003c\/p\u003e\n\u003cp\u003eArimigen™ acts as an Elevator of total testosterone and liberator of free testosterone. As a powerful aromatase inhibitor, Arimigen™ also possesses notable testosterone stimulating properties. The aromatase inhibiting action reduces the signal that estrogen sends to the brain to suppress endogenous testosterone production (estrogen is a main feedback signal to control the release of testosterone, thus increasing the testicular output of testosterone). Arimigen™ thus assists in resetting the body's level of its own natural testosterone production by regulating the activity of the hypothalamic-pituitary-testicular axis (HPTA), which constantly adjusts the body's production of testosterone to maintain target blood levels. Continued use of Arimigen™ results in not only a significant reduction in the production of estrogen, but also a corresponding substantial increase in endogenous testosterone. Only Arimigen™ addresses all possible channels to estrogen maintenance and free testosterone elevation, which means optimal hormonal levels for muscle building and dry, hard physique.\u003c\/p\u003e\n\u003cp\u003eArimigen™ is based primarily on the testosterone, LH, FSH, libido and lean mass extreme stimulatory compound referred to as ‘Akarkara’ in Anacyclus pyrethrum, the information has been widely recognized in the Ayurvedic system of Indian medicine for over 2 centuries. Not a “discovery” for us, more of an advanced understanding was accomplished with patience on our part. Our testing, research and patience paid off by allowing us to release of Arimigen™ with a multi-independent study validated extract that \u003cstrong\u003eoutperformed the other common extract on the market by over 71% for mass gain!\u003c\/strong\u003e Arimigen™ also contains a \"supporting cast\" of ingredients that have individually been shown to support inhibition of excessive estrogen formation that make Arimigen™ truly revolutionary.\u003c\/p\u003e\n\u003cp\u003eThe first of these ingredients is an extract derived from the leaves of Brassaiopsis glomerulata (standardized to 6ß-hydroxystimasta-4- en-3-one and N-benzoyl-L-phenylalanine methyl ester). APS’s unique extraction process of this plant results an extract that produce 13 isolated estrogen-modulating compounds.\u003c\/p\u003e\n\u003cp\u003eAs mentioned above, the attractive effect of Brassaiopsis glomerulata extract is due to its aromatase inhibition property. Aromatase is the enzyme responsible for catalyzing the last steps of biosynthesis of estrogens (estrone and estradiol) from androgens (androstenedione and testosterone). Inhibition of aromatase has been shown to reduce estrogen production throughout the body to nearly undetectable levels.\u003c\/p\u003e\n\u003cp\u003e\u003cimg width=\"411\" height=\"83\" style=\"float: right;\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/ARIMIGEN_09c86494-ddcc-4f62-bb5f-d0f34123edb8.png?4199550805568428710\"\u003eBodybuilders that take anabolic ingredients often use aromatase inhibitors in order to minimize or avoid estrogenic effects. Aromatase inhibitors can prevent elevated levels of testosterone from being converted to excess estrogen and have also been shown to reverse age-related decline in testosterone.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eArimigen™ also contains a 98% highly purified version of Chrysin (5,7-dihydroxyflavone) which is the name of a monoflavone extracted from a plant called \"Passiflora caerulea\". Flavones, a group of compounds found in many different plants, are known to have numerous therapeutic effects. Of all the unique biological activities, Chrysin has generated the most interest as an aromatase inhibitor, which has also been shown to control estrogen through modulation of estrogen metabolism. In the May ’96 issue of \u003cem\u003eMuscle Media 2000\u003c\/em\u003e, the late Dan Duchaine, known as the “steroid guru,” discussed a substance that he dubbed “Flavone-X.” Duchaine claimed that Flavone-X, which was a natural flavone existing in plants, could boost testosterone an average of 20 to 30 percent. It turned out that Flavone-X was actually an esoteric substance called chrysin. A study had been published that compared the activity of a number of natural flavonoids and flavones to the drug Cydadren in their ability to inhibit the enzyme aromatase, which works by converting androgens, including testosterone, into estrogen. Blocking the effect of aromatase would not only lower estrogen levels but also boost testosterone. Elevated estrogen in the blood sends an inhibitory message to the pituitary gland in the brain, which responds by lowering the output of gonadatropins, hormones that stimulate the body’s testosterone production.\u003c\/p\u003e\n\u003cp\u003eAs most of you know this was one of Duchain's only \"misses\" when it came to finding innovative compounds....\u003cstrong\u003ebut was it? \u003c\/strong\u003eIn Human tissue experiments with this monoflavone demonstrated the ability to limit aromatase activity. Aromatase is an enzyme that is found in various tissues within the body and is responsible for the conversion of androstenedione and testosterone into estrogen. This conversion is utilized by the body to keep Testosterone: Estrogen ratios in balance. When athletes are in quest of increasing lean body mass, maximizing serum testosterone levels is of paramount concern. In the study that compared natural flavonoids to cytadren, chrysin came out on top, actually showing effects against aromatase that were superior to the potent drug. The problem was, it was an in vitro, or isolated-cell, study. The question then became, How well does chrysin work in the body? Humans had unknowingly been consuming chrysin, since it’s found naturally in honey, propolis and in the passion flower plant, but initial animal-based and later human studies proved to be disappointing.\u003c\/p\u003e\n\u003cp\u003eIt’s clear that chrysin seemed to work better in a test tube than it does in the human body. The reason for that was due to the difficulty in absorbing chrysin into the body. That was when the supplement industry gave up on Chrysin — but not APS researchers who were big fans of Duchaine's and saw him develop a novel delivery system with DMSO for Finaplex pellets, which was definitely ahead of his time in delivery systems.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTHE KEY TO CHRYSIN'S SUCCESS OR FAILURE IS ALL IN THE DELIVERY! \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhether a man's sex hormones are out of whack because of father time, or because of a self-inflicted blast of anabolic steroids, maintaining elevated levels of testosterone, while minimizing the production of estradiol and DHT, is one of the most important steps men can take to remain healthy, improve performance, and keep hard-earned muscle intact. Arimigen will help to restore healthy testosterone to estradiol ratios, or can be used by a bodybuilder looking for an estrogen-squashing, testosterone-unleashing, muscle-building supplement for the anabolic support required to achieve a hard, lean physique!\u003c\/p\u003e\n\u003cp\u003eChrysin is a well studied nutraceutical and its benefits greatly depend on its solubilization (bioaccessibility) and subsequent absorption through cell lining so that it can reach lymphatic systemic\/general circulation. Unfortunately, Chrysin has low water solubility and undergoes rapid metabolism on oral delivery. Lipids have shown to affect the absorption of poorly soluble nutraceuticals such as Chrysin by enhancing solubilization in the intestinal milieu through alterations to the composition and character of the colloidal environment – e.g. vesicles, mixed micelles when delivered orally. The presence of lipids in the GI tract stimulates the contraction of gall bladder. This leads to the release of biliary and pancreatic secretions such as phospholipids (PL), cholesterol (Ch), pancreatic lipase and other enzymes. PL and Ch form intestinal mixed micelles which increase the solubilization of lipophilic bioactives. In addition, the digestion of lipids leads to the formation of free fatty acids and monoglycerides, these along with biliary compounds\u003c\/p\u003e\n\u003cp\u003eand emulsifiers or co-solvents used in formulation, aid in the formation of mixed micelles, micelles, liposomes and vesicles which further prevent the precipitation of lipophilic bioactives and increase their solubilization. The solubilized bioactives are easily absorbed through the intestinal cell wall. Thus this mechanism directly affects the bioavailability of lipophilic bioactives by increasing its bioaccessibility.\u003c\/p\u003e\n\u003cp\u003eAPS Researchers studied three types of lipid based delivery systems were evaluated for increasing bioaccessibility of Chrysin. With over 10 types of delivery methods studies we found four types of lipid based delivery systems, namely nanoemulsions, gel-like emulsions, Cocrystallization and organogels that proved effective in increasing the bioaccessibility of Chrysin when compared to the dispersion of the compound in water. APS Researchers concluded that less than 1% of the Chrysin was absorbed unchanged in the gastrointestinal tract. This was not surprising given that Chrysin has extremely low water solubility, a major factor in drug absorption. Not only was Chrysin absorbed poorly but also it was conjugated extensively in the liver following oral administration. Our proprietary two stage delivery system was shown to increase the solubility 14-fold. We hypothesized that this improved solubility would translate into enhanced systemic absorption of Chrysin. This hypothesis was supported in our pharmacokinetic study. The outperformed Chrysin with increases in bioavailability up to nearly 10-fold!\u003c\/p\u003e\n\u003cp\u003eIn addition to these ingredients and cutting-edge science, an extremely high quality Urtica Dioica extract is also included in Arimigen™ because it has been shown to support two complementary pathways involved estrogen modulation and free testosterone enhancement — most notably for its known contribution to enhancing free testosterone levels via inhibition of the action of SHBG.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eArimigen™ is a formula that is designed to optimize and support an anabolic environment by decreasing estrogen and increasing testosterone levels. This formulation aggressively combats heightened estrogen levels often associated with heavy steroid, prohormone, and prosteroid cycles. \u003c\/span\u003e\u003cbr\u003e \u003cbr\u003e \u003cspan\u003eUltimately, Arimigen™ allows the user to get the anabolic benefits of heightened testosterone levels without the negative side-effects of estrogen (a by-product of heightened testosterone), water retention and body-fat accumulation that usually accompany heightened levels of testosterone in the body. Arimigen™ is comprised of specific compounds working synergistically at blocking testosterone from converting into estrogens. \u003c\/span\u003e\u003cbr\u003e \u003cspan\u003eArimigen™ also works by metabolizing active estrogens into inactive estrogen metabolites, blocking estrogen, and by freeing excess estrogen from the body. What's more, Arimigen™ can down regulate SHBG (Sex hormone-binding globulin) and therefore known to support increased FREE testosterone levels from within the body. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eAs a dietary supplement, take 2 tablets one or two times daily on an empty stomach. Take 8-12 hours apart. Do not exceed 4 tablets per day.\u003c\/p\u003e","published_at":"2015-06-25T16:51:00-05:00","created_at":"2015-07-28T14:32:58-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":["Add Muscle","Muscle \u0026 Strength","Testosterone Support"],"price":5995,"price_min":5995,"price_max":5995,"available":false,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":5113776769,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APARI60","requires_shipping":true,"taxable":false,"featured_image":null,"available":false,"name":"Arimigen™","public_title":null,"options":["Default Title"],"price":5995,"weight":227,"compare_at_price":null,"inventory_quantity":0,"inventory_management":"shopify","inventory_policy":"deny","barcode":"649241899976"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/ARIMIGEN.jpg?v=1512488271"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/ARIMIGEN.jpg?v=1512488271","options":["Title"],"content":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eArimigen\u003c\/strong\u003e\u003cstrong\u003e™\u003c\/strong\u003e \u003cstrong\u003eSupports Decrease of Estrogen \u0026amp; Increase of Testosterone Levels!* \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eArimigen™ — APS Nutrition's novel Aromatase Inhibitor is a new ground breaking formula designed to optimize an anabolic environment by decreasing estrogen and increasing testosterone levels. Arimigen™ is a multi-pathway formulation that minimizes or eliminates the undesirable effects associated with an estrogen dominant environment. Arimigen™ maintains the correct testosterone to estrogen ratios that yield the benefits associated with normal estrogen levels. Arimigen™ acts as an anti-aromatase agent and is thus a powerful elevator of total testosterone and maximum liberator of free testosterone. This one-of-a- kind formulation is exclusively manufactured by APS and aggressively combats heightened estrogen levels that can come with elevated testosterone. *\u003c\/p\u003e\n\u003cbr\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/arimigen_large.png?10323656229900534673\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eArimigen™ allows the user to get the anabolic benefits of increased testosterone levels without the negative side-effects of estrogen (the downside of elevated testosterone), water retention and unattractive body-weight accumulation that usually accompany elevated levels of testosterone in the body. Arimigen™ is appropriately used when using substantial amounts of aromatizing hormones or prohormones. Arimigen™ also works by metabolizing active estrogens into inactive estrogen metabolites, blocking estrogen at the actual estrogen receptor site in male breast tissue, and by freeing excess estrogen from the body. Arimigen™ also will help to down regulate SHBG (Sex hormone-binding globulin) and therefore known to support increased FREE testosterone levels.\u003c\/p\u003e\n\u003cp\u003eThe Arimigen™ proprietary formula was developed by combining naturally occurring aromatase inhibitors and inhibitors of the action of SHBG. The dietary supplement Arimigen™ is a multi-pathway agent that exerts its influence by blocking various stages in the aromatase process and by inhibiting SHBG's action; an activity not clearly addressed by any of the aromatase inhibiting or anti-estrogen products. Further, it appears that use of Arimigen™ may result in long-term blocking of selective anabolic estrogen receptors and\/or inhibition of selective estrogen signaling. This activity has not been addressed by any known dietary supplements or pharmacological agents. \u003c\/p\u003e\n\u003cp\u003eArimigen™ acts as an Elevator of total testosterone and liberator of free testosterone. As a powerful aromatase inhibitor, Arimigen™ also possesses notable testosterone stimulating properties. The aromatase inhibiting action reduces the signal that estrogen sends to the brain to suppress endogenous testosterone production (estrogen is a main feedback signal to control the release of testosterone, thus increasing the testicular output of testosterone). Arimigen™ thus assists in resetting the body's level of its own natural testosterone production by regulating the activity of the hypothalamic-pituitary-testicular axis (HPTA), which constantly adjusts the body's production of testosterone to maintain target blood levels. Continued use of Arimigen™ results in not only a significant reduction in the production of estrogen, but also a corresponding substantial increase in endogenous testosterone. Only Arimigen™ addresses all possible channels to estrogen maintenance and free testosterone elevation, which means optimal hormonal levels for muscle building and dry, hard physique.\u003c\/p\u003e\n\u003cp\u003eArimigen™ is based primarily on the testosterone, LH, FSH, libido and lean mass extreme stimulatory compound referred to as ‘Akarkara’ in Anacyclus pyrethrum, the information has been widely recognized in the Ayurvedic system of Indian medicine for over 2 centuries. Not a “discovery” for us, more of an advanced understanding was accomplished with patience on our part. Our testing, research and patience paid off by allowing us to release of Arimigen™ with a multi-independent study validated extract that \u003cstrong\u003eoutperformed the other common extract on the market by over 71% for mass gain!\u003c\/strong\u003e Arimigen™ also contains a \"supporting cast\" of ingredients that have individually been shown to support inhibition of excessive estrogen formation that make Arimigen™ truly revolutionary.\u003c\/p\u003e\n\u003cp\u003eThe first of these ingredients is an extract derived from the leaves of Brassaiopsis glomerulata (standardized to 6ß-hydroxystimasta-4- en-3-one and N-benzoyl-L-phenylalanine methyl ester). APS’s unique extraction process of this plant results an extract that produce 13 isolated estrogen-modulating compounds.\u003c\/p\u003e\n\u003cp\u003eAs mentioned above, the attractive effect of Brassaiopsis glomerulata extract is due to its aromatase inhibition property. Aromatase is the enzyme responsible for catalyzing the last steps of biosynthesis of estrogens (estrone and estradiol) from androgens (androstenedione and testosterone). Inhibition of aromatase has been shown to reduce estrogen production throughout the body to nearly undetectable levels.\u003c\/p\u003e\n\u003cp\u003e\u003cimg width=\"411\" height=\"83\" style=\"float: right;\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/ARIMIGEN_09c86494-ddcc-4f62-bb5f-d0f34123edb8.png?4199550805568428710\"\u003eBodybuilders that take anabolic ingredients often use aromatase inhibitors in order to minimize or avoid estrogenic effects. Aromatase inhibitors can prevent elevated levels of testosterone from being converted to excess estrogen and have also been shown to reverse age-related decline in testosterone.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eArimigen™ also contains a 98% highly purified version of Chrysin (5,7-dihydroxyflavone) which is the name of a monoflavone extracted from a plant called \"Passiflora caerulea\". Flavones, a group of compounds found in many different plants, are known to have numerous therapeutic effects. Of all the unique biological activities, Chrysin has generated the most interest as an aromatase inhibitor, which has also been shown to control estrogen through modulation of estrogen metabolism. In the May ’96 issue of \u003cem\u003eMuscle Media 2000\u003c\/em\u003e, the late Dan Duchaine, known as the “steroid guru,” discussed a substance that he dubbed “Flavone-X.” Duchaine claimed that Flavone-X, which was a natural flavone existing in plants, could boost testosterone an average of 20 to 30 percent. It turned out that Flavone-X was actually an esoteric substance called chrysin. A study had been published that compared the activity of a number of natural flavonoids and flavones to the drug Cydadren in their ability to inhibit the enzyme aromatase, which works by converting androgens, including testosterone, into estrogen. Blocking the effect of aromatase would not only lower estrogen levels but also boost testosterone. Elevated estrogen in the blood sends an inhibitory message to the pituitary gland in the brain, which responds by lowering the output of gonadatropins, hormones that stimulate the body’s testosterone production.\u003c\/p\u003e\n\u003cp\u003eAs most of you know this was one of Duchain's only \"misses\" when it came to finding innovative compounds....\u003cstrong\u003ebut was it? \u003c\/strong\u003eIn Human tissue experiments with this monoflavone demonstrated the ability to limit aromatase activity. Aromatase is an enzyme that is found in various tissues within the body and is responsible for the conversion of androstenedione and testosterone into estrogen. This conversion is utilized by the body to keep Testosterone: Estrogen ratios in balance. When athletes are in quest of increasing lean body mass, maximizing serum testosterone levels is of paramount concern. In the study that compared natural flavonoids to cytadren, chrysin came out on top, actually showing effects against aromatase that were superior to the potent drug. The problem was, it was an in vitro, or isolated-cell, study. The question then became, How well does chrysin work in the body? Humans had unknowingly been consuming chrysin, since it’s found naturally in honey, propolis and in the passion flower plant, but initial animal-based and later human studies proved to be disappointing.\u003c\/p\u003e\n\u003cp\u003eIt’s clear that chrysin seemed to work better in a test tube than it does in the human body. The reason for that was due to the difficulty in absorbing chrysin into the body. That was when the supplement industry gave up on Chrysin — but not APS researchers who were big fans of Duchaine's and saw him develop a novel delivery system with DMSO for Finaplex pellets, which was definitely ahead of his time in delivery systems.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTHE KEY TO CHRYSIN'S SUCCESS OR FAILURE IS ALL IN THE DELIVERY! \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhether a man's sex hormones are out of whack because of father time, or because of a self-inflicted blast of anabolic steroids, maintaining elevated levels of testosterone, while minimizing the production of estradiol and DHT, is one of the most important steps men can take to remain healthy, improve performance, and keep hard-earned muscle intact. Arimigen will help to restore healthy testosterone to estradiol ratios, or can be used by a bodybuilder looking for an estrogen-squashing, testosterone-unleashing, muscle-building supplement for the anabolic support required to achieve a hard, lean physique!\u003c\/p\u003e\n\u003cp\u003eChrysin is a well studied nutraceutical and its benefits greatly depend on its solubilization (bioaccessibility) and subsequent absorption through cell lining so that it can reach lymphatic systemic\/general circulation. Unfortunately, Chrysin has low water solubility and undergoes rapid metabolism on oral delivery. Lipids have shown to affect the absorption of poorly soluble nutraceuticals such as Chrysin by enhancing solubilization in the intestinal milieu through alterations to the composition and character of the colloidal environment – e.g. vesicles, mixed micelles when delivered orally. The presence of lipids in the GI tract stimulates the contraction of gall bladder. This leads to the release of biliary and pancreatic secretions such as phospholipids (PL), cholesterol (Ch), pancreatic lipase and other enzymes. PL and Ch form intestinal mixed micelles which increase the solubilization of lipophilic bioactives. In addition, the digestion of lipids leads to the formation of free fatty acids and monoglycerides, these along with biliary compounds\u003c\/p\u003e\n\u003cp\u003eand emulsifiers or co-solvents used in formulation, aid in the formation of mixed micelles, micelles, liposomes and vesicles which further prevent the precipitation of lipophilic bioactives and increase their solubilization. The solubilized bioactives are easily absorbed through the intestinal cell wall. Thus this mechanism directly affects the bioavailability of lipophilic bioactives by increasing its bioaccessibility.\u003c\/p\u003e\n\u003cp\u003eAPS Researchers studied three types of lipid based delivery systems were evaluated for increasing bioaccessibility of Chrysin. With over 10 types of delivery methods studies we found four types of lipid based delivery systems, namely nanoemulsions, gel-like emulsions, Cocrystallization and organogels that proved effective in increasing the bioaccessibility of Chrysin when compared to the dispersion of the compound in water. APS Researchers concluded that less than 1% of the Chrysin was absorbed unchanged in the gastrointestinal tract. This was not surprising given that Chrysin has extremely low water solubility, a major factor in drug absorption. Not only was Chrysin absorbed poorly but also it was conjugated extensively in the liver following oral administration. Our proprietary two stage delivery system was shown to increase the solubility 14-fold. We hypothesized that this improved solubility would translate into enhanced systemic absorption of Chrysin. This hypothesis was supported in our pharmacokinetic study. The outperformed Chrysin with increases in bioavailability up to nearly 10-fold!\u003c\/p\u003e\n\u003cp\u003eIn addition to these ingredients and cutting-edge science, an extremely high quality Urtica Dioica extract is also included in Arimigen™ because it has been shown to support two complementary pathways involved estrogen modulation and free testosterone enhancement — most notably for its known contribution to enhancing free testosterone levels via inhibition of the action of SHBG.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eArimigen™ is a formula that is designed to optimize and support an anabolic environment by decreasing estrogen and increasing testosterone levels. This formulation aggressively combats heightened estrogen levels often associated with heavy steroid, prohormone, and prosteroid cycles. \u003c\/span\u003e\u003cbr\u003e \u003cbr\u003e \u003cspan\u003eUltimately, Arimigen™ allows the user to get the anabolic benefits of heightened testosterone levels without the negative side-effects of estrogen (a by-product of heightened testosterone), water retention and body-fat accumulation that usually accompany heightened levels of testosterone in the body. Arimigen™ is comprised of specific compounds working synergistically at blocking testosterone from converting into estrogens. \u003c\/span\u003e\u003cbr\u003e \u003cspan\u003eArimigen™ also works by metabolizing active estrogens into inactive estrogen metabolites, blocking estrogen, and by freeing excess estrogen from the body. What's more, Arimigen™ can down regulate SHBG (Sex hormone-binding globulin) and therefore known to support increased FREE testosterone levels from within the body. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eAs a dietary supplement, take 2 tablets one or two times daily on an empty stomach. Take 8-12 hours apart. Do not exceed 4 tablets per day.\u003c\/p\u003e"} Muscle Building Supplement Chain'd Reaction™ DESCRIPTION Chain'd-Reaction®- The Ultimate (BCAA) Branched Chain Amino Acid Tripeptides & Recovery Aid for Muscle Growth!* Chain'd-Reaction® is an advanced post-workout performance supplement specifically formulated... DESCRIPTION Chain'd-Reaction®- The Ultimate (BCAA) Branched Chain Amino Acid Tripeptides & Recovery Aid for Muscle... SKU: ALCHA60APP Availability: In Stock $ 44.95 Select options Quick View {"id":5442598529,"title":"Chain'd Reaction™","handle":"chaind-reaction","description":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003cp\u003eChain'd-Reaction®- The Ultimate (BCAA) Branched Chain Amino Acid Tripeptides \u0026amp; Recovery Aid for Muscle Growth!* \u003cbr\u003e\u003cbr\u003eChain'd-Reaction® is an advanced post-workout performance supplement specifically formulated to help your body recover from the extreme physical demands of high-intensity workouts. Ideal for elite athletes and hardcore bodybuilders, Chain'd-Reaction®, can also help weekend warriors and beginners. Chain'd-Reaction® is an incredible breakthrough in the supplementation of Branched Chain Amino Acids (BCAA's) and recovery aids for muscle growth and repair after grueling training sessions. \u003cbr\u003e\u003cbr\u003eMost marketing companies hype some different ratios of BCAA's or mix in inferior amino acids to make you feel like you are getting \"more aminos.\" APS Nutrition utilizes the scientifically-proven 2:1:1 ratio but stands out from the crowd significantly in two ways - \u003cbr\u003e\u003cbr\u003e (1) Chain'd-Reaction® is an ultra-concentrated BCAA formula that delivers a \"proprietary\" tripeptide and ultra-micronization BCAA. Chain'd-Reaction® also contains in a time releasing matrix of L-Leucine to the muscles faster and for longer periods of time than typical BCAA products. APS Nutrition always known for its innovation has \"turned the BCAA category on its head!\"\u003cbr\u003e (2) Chain'd-Reaction® utilizes the transport of peptides into cells, that is a well-documented biological phenomenon, which is accomplished by specific energy-dependent transporters found in a number of organisms such as amino acids. The amino acid\/peptide transporter family of proteins was uncovered by sequence analysis of a number of recently discovered peptide transport proteins. The protein shows a distinct preference for tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/chaindreaction_large.png?6719628960371224531\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eGlutathione is an important tripeptide present in significant concentrations in all tissues. It contains glutamic acid, cysteine, and glycine. What is unusual about the structure of glutathione Instead of the usual backbone, the carboxyl acid \"side chain\" is part of the backbone peptide structure. The normal carboxyl group is the so called” side chain” in this case. Glutathione is your body’s most powerful antioxidant and has even been called “the master antioxidant”. It is a tripeptide found inside every single cell in your body. Scientists know that strenuous and\/or prolonged exercise deplete glutathione. In fact, this is one cause for the fatigue that comes with exercise. However, it has other effects that are even less helpful. It aids the body, in producing the extra energy or ATP (adenosine triphosphate) needed for vigorous exercise, produces many more singlet oxygen atoms or free radicals. Cleaning these up uses up the body’s reserves of glutathione. It takes some time for the body to regenerate or synthesize more glutathione, so the person becomes tired while some damage occurs inside the cells as a result of the presence of too many free radicals or singlet oxygen atoms. Chain'd-Reaction® features advanced Setria® Glutathione, a \"reduced\" form your body can recognize and readily absorb. \u003cbr\u003e\u003cbr\u003eChain'd-Reaction® is able to achieve the anabolic BCAA ratio by combining Pharmaceutical-Grade tripeptide-form of L-Leucine, L-Isoleucine and L-Valine amino acids along with L-Glutamine and other Anabolic Agents for maximum muscle-building performance. In recent times, these amino acids have been investigated for their potential anti-catabolic (preventing muscle breakdown) and muscle building effects. Recent university research shows that Leucine enriched beverages consumed with exercise synergistically activate and prolong activity of the mTOR signaling pathway, which increases muscle anabolic potential (muscle growth). The mTOR pathway is the \"trigger\" that signals the very genesis of muscle protein synthesis.*\u003cbr\u003e\u003cbr\u003eAmino acids are the building blocks of protein. Branched chain amino acids (BCAAs) are so called because of their structure, which includes a “side chain” of one carbon atom and three hydrogen atoms. There are three BCAAs: leucine, isoleucine, and valine. Of these, leucine is the most heavily researched, and appears to offer the biggest physiological benefit. \u003cbr\u003e\u003cbr\u003eFor the technical geeks, these hydrophobic (water-fearing) amino acids are referred to as “aliphatic” (from the Greek aleiphar, or oil), as their central carbon attaches to a branched non-cyclic, open carbon chain. (See BCAA structure below)\u003cbr\u003e\u003cbr\u003eBCAAs provide the basis for protein synthesis and energy. In fact, BCAAs can comprise up to one-third of muscle protein. Because of their prevalence and involvement in protein synthesis and energy production, BCAAs are important to many metabolic processes. However, if BCAAs are going to be meaningful in these processes, they must be available to the body. This means we have to eat enough BCAAs, and at the right times, to enable such processes to occur.\u003cbr\u003e\u003cbr\u003eL- Glutamine represents over 60% of the amino acid content in the amino acid pool of muscle tissue. Intense training and exercise put greater demands on your body's need for Glutamine, making it a conditionally essential amino acid. Chain'd-Reaction® micronized L-Glutamine represents a leap forward in Glutamine supplementation. Chain'd-Reaction® uses a state-of-the- art particle micronization technology called Micro-Rx™. Each tiny particle of Chain'd-Reaction® is 20 times smaller than regular Glutamine powder. This allows for ultra fast absorption and utilization. Glutamine is the most common amino acid in the body and is key to the metabolism and maintenance of muscle tissue. Glutamine is also the highest concentrated amino acid in the muscle cell and acts as a primary shuttle for nitrogen from the bloodstream to inside the muscle cell, which is essential for the support of muscle tissue and growth hormone elevation.\u003cbr\u003e\u003cbr\u003eEnter....Chain'd-Reaction® when combined with regular exercise are designed to support:\u003cbr\u003e\u003cbr\u003e • Protein Synthesis \/ Anabolism*\u003cbr\u003e • Anti-Catabolism \/ Muscle Sparing*\u003cbr\u003e • Glycogen Resynthesis*\u003cbr\u003e • Helps Preserve Lean Muscle*\u003cbr\u003e • Rebuild Muscle \u0026amp; Recover Faster*\u003cbr\u003e • Increase Growth Hormone*\u003cbr\u003e\u003cbr\u003eChain'd-Reaction® provides a tripeptide of the essential branched chain amino acids: L-Leucine, L-Isoleucine and L-Valine. During times of metabolic stress (such as high intensity exercise), BCAAs may become fuel for your muscles and help aid in protein synthesis and prevent catabolism (muscle breakdown). L-Leucine, in conjunction with exercise, may activate the mTOR pathway that supports muscle growth. To drastically increase the efficacy of BCAA delivery in Chain'd-Reaction®, these powerful, muscle building agents are continually dispersed into the muscular environment utilizing a two-pronged, sustained-release delivery mechanism that consists of APS's Micro-Rx™ and Extend-Rx™ technologies- manufacturing know-how previously beyond the scope of the sports nutrition industry. \u003cbr\u003e\u003cbr\u003eThe unique combination of these controlled dispersion, \"agglomeration-like\" technologies produces rapid disintegration of the BCAA and Glutamine compounds, whose highly micronized particles are more quickly and completely digested (without stomach upset or digestive disturbance) on their way to becoming available to the body's muscle-making machinery. Favorable Anabolic\/Anti-Catabolic changes then accelerate and enhance the uptake of BCAA's and anabolic agents, which leads to increased Protein Synthesis \/ Anabolism, Anti- Catabolism \/ Muscle Sparing, Supporting Muscle Growth and Endurance, Glycogen Resynthesis, Helps Preserve Lean Muscle, Increases Growth Hormone and Helps Rebuild Muscle \u0026amp; Recover Faster.*\u003cbr\u003e\u003cbr\u003eAdvances in Nutraceutical sports chemistry have resulted in compounds that target a variety of pathways to develop muscle mass and strength. There are now non-hormonal, highly anabolic compounds that zero-in on the juncture of protein chain assembly within muscle cells for more rapid protein synthesis. There are compounds designed to seize the \"window of opportunity\" in which muscle cells demonstrate a high affinity for the uptake of muscle-building compounds. This \"window of opportunity\" opens at the onset of intense muscular contraction and remains open until a short period immediately after training. Pre-workout supplements are designed to target the initial phase of the \"window of opportunity\" by providing muscles with compounds that allow them to sustain the level of muscular contraction required to complete a high intensity workout. Likewise, post-workout supplements target the next phase of the \"window of opportunity\" that occurs immediately after training in which depleted, wounded muscles are crying out for compounds that will replenish them with the muscle cell constituents needed to optimize recovery and promote growth of new muscle tissue. \u003cbr\u003e\u003cbr\u003eThe result is the replenishment of the key compounds that produce hydration of muscle cells. Protein synthesis is enhanced due to Amino acids being shuttled more efficiently into the muscles. These events halt protein catabolism and accelerate protein anabolism. The outcome is muscle preservation and new muscular growth. APS Nutrition speaks natural sports supplement chemistry, which means that if muscle is your game, then Chain'd-Reaction® is your real end-game!\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eAs a dietary supplement, mix 2 level scoops (12g) in 12 oz of water and mix well, 1-3 times daily.\u003c\/p\u003e","published_at":"2016-03-15T15:14:00-05:00","created_at":"2016-03-15T15:19:07-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":[],"price":4495,"price_min":4495,"price_max":4495,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":39686571341,"title":"Appletini","option1":"Appletini","option2":null,"option3":null,"sku":"ALCHA60APP","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"Chain'd Reaction™ - Appletini","public_title":"Appletini","options":["Appletini"],"price":4495,"weight":454,"compare_at_price":null,"inventory_quantity":-6,"inventory_management":null,"inventory_policy":"deny","barcode":""},{"id":16715696641,"title":"Blue Raspberry","option1":"Blue Raspberry","option2":null,"option3":null,"sku":"APCHA25BR","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"Chain'd Reaction™ - Blue Raspberry","public_title":"Blue Raspberry","options":["Blue Raspberry"],"price":4495,"weight":454,"compare_at_price":null,"inventory_quantity":-27,"inventory_management":null,"inventory_policy":"deny","barcode":""},{"id":16715696705,"title":"Exotic Fruit","option1":"Exotic Fruit","option2":null,"option3":null,"sku":"APCHA25EXO","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"Chain'd Reaction™ - Exotic Fruit","public_title":"Exotic Fruit","options":["Exotic Fruit"],"price":4495,"weight":454,"compare_at_price":null,"inventory_quantity":-30,"inventory_management":null,"inventory_policy":"deny","barcode":""},{"id":16715696769,"title":"Rocket Pop","option1":"Rocket Pop","option2":null,"option3":null,"sku":"APCHA25ROC","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"Chain'd Reaction™ - Rocket Pop","public_title":"Rocket Pop","options":["Rocket Pop"],"price":4495,"weight":454,"compare_at_price":null,"inventory_quantity":-49,"inventory_management":null,"inventory_policy":"deny","barcode":""},{"id":16715696577,"title":"Watermelon","option1":"Watermelon","option2":null,"option3":null,"sku":"APCHA25WAT","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"Chain'd Reaction™ - Watermelon","public_title":"Watermelon","options":["Watermelon"],"price":4495,"weight":454,"compare_at_price":null,"inventory_quantity":-70,"inventory_management":null,"inventory_policy":"deny","barcode":""}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/CHAIND_REACTION_APPLETINI.jpg?v=1512499619"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/CHAIND_REACTION_APPLETINI.jpg?v=1512499619","options":["Flavor"],"content":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003cp\u003eChain'd-Reaction®- The Ultimate (BCAA) Branched Chain Amino Acid Tripeptides \u0026amp; Recovery Aid for Muscle Growth!* \u003cbr\u003e\u003cbr\u003eChain'd-Reaction® is an advanced post-workout performance supplement specifically formulated to help your body recover from the extreme physical demands of high-intensity workouts. Ideal for elite athletes and hardcore bodybuilders, Chain'd-Reaction®, can also help weekend warriors and beginners. Chain'd-Reaction® is an incredible breakthrough in the supplementation of Branched Chain Amino Acids (BCAA's) and recovery aids for muscle growth and repair after grueling training sessions. \u003cbr\u003e\u003cbr\u003eMost marketing companies hype some different ratios of BCAA's or mix in inferior amino acids to make you feel like you are getting \"more aminos.\" APS Nutrition utilizes the scientifically-proven 2:1:1 ratio but stands out from the crowd significantly in two ways - \u003cbr\u003e\u003cbr\u003e (1) Chain'd-Reaction® is an ultra-concentrated BCAA formula that delivers a \"proprietary\" tripeptide and ultra-micronization BCAA. Chain'd-Reaction® also contains in a time releasing matrix of L-Leucine to the muscles faster and for longer periods of time than typical BCAA products. APS Nutrition always known for its innovation has \"turned the BCAA category on its head!\"\u003cbr\u003e (2) Chain'd-Reaction® utilizes the transport of peptides into cells, that is a well-documented biological phenomenon, which is accomplished by specific energy-dependent transporters found in a number of organisms such as amino acids. The amino acid\/peptide transporter family of proteins was uncovered by sequence analysis of a number of recently discovered peptide transport proteins. The protein shows a distinct preference for tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/chaindreaction_large.png?6719628960371224531\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eGlutathione is an important tripeptide present in significant concentrations in all tissues. It contains glutamic acid, cysteine, and glycine. What is unusual about the structure of glutathione Instead of the usual backbone, the carboxyl acid \"side chain\" is part of the backbone peptide structure. The normal carboxyl group is the so called” side chain” in this case. Glutathione is your body’s most powerful antioxidant and has even been called “the master antioxidant”. It is a tripeptide found inside every single cell in your body. Scientists know that strenuous and\/or prolonged exercise deplete glutathione. In fact, this is one cause for the fatigue that comes with exercise. However, it has other effects that are even less helpful. It aids the body, in producing the extra energy or ATP (adenosine triphosphate) needed for vigorous exercise, produces many more singlet oxygen atoms or free radicals. Cleaning these up uses up the body’s reserves of glutathione. It takes some time for the body to regenerate or synthesize more glutathione, so the person becomes tired while some damage occurs inside the cells as a result of the presence of too many free radicals or singlet oxygen atoms. Chain'd-Reaction® features advanced Setria® Glutathione, a \"reduced\" form your body can recognize and readily absorb. \u003cbr\u003e\u003cbr\u003eChain'd-Reaction® is able to achieve the anabolic BCAA ratio by combining Pharmaceutical-Grade tripeptide-form of L-Leucine, L-Isoleucine and L-Valine amino acids along with L-Glutamine and other Anabolic Agents for maximum muscle-building performance. In recent times, these amino acids have been investigated for their potential anti-catabolic (preventing muscle breakdown) and muscle building effects. Recent university research shows that Leucine enriched beverages consumed with exercise synergistically activate and prolong activity of the mTOR signaling pathway, which increases muscle anabolic potential (muscle growth). The mTOR pathway is the \"trigger\" that signals the very genesis of muscle protein synthesis.*\u003cbr\u003e\u003cbr\u003eAmino acids are the building blocks of protein. Branched chain amino acids (BCAAs) are so called because of their structure, which includes a “side chain” of one carbon atom and three hydrogen atoms. There are three BCAAs: leucine, isoleucine, and valine. Of these, leucine is the most heavily researched, and appears to offer the biggest physiological benefit. \u003cbr\u003e\u003cbr\u003eFor the technical geeks, these hydrophobic (water-fearing) amino acids are referred to as “aliphatic” (from the Greek aleiphar, or oil), as their central carbon attaches to a branched non-cyclic, open carbon chain. (See BCAA structure below)\u003cbr\u003e\u003cbr\u003eBCAAs provide the basis for protein synthesis and energy. In fact, BCAAs can comprise up to one-third of muscle protein. Because of their prevalence and involvement in protein synthesis and energy production, BCAAs are important to many metabolic processes. However, if BCAAs are going to be meaningful in these processes, they must be available to the body. This means we have to eat enough BCAAs, and at the right times, to enable such processes to occur.\u003cbr\u003e\u003cbr\u003eL- Glutamine represents over 60% of the amino acid content in the amino acid pool of muscle tissue. Intense training and exercise put greater demands on your body's need for Glutamine, making it a conditionally essential amino acid. Chain'd-Reaction® micronized L-Glutamine represents a leap forward in Glutamine supplementation. Chain'd-Reaction® uses a state-of-the- art particle micronization technology called Micro-Rx™. Each tiny particle of Chain'd-Reaction® is 20 times smaller than regular Glutamine powder. This allows for ultra fast absorption and utilization. Glutamine is the most common amino acid in the body and is key to the metabolism and maintenance of muscle tissue. Glutamine is also the highest concentrated amino acid in the muscle cell and acts as a primary shuttle for nitrogen from the bloodstream to inside the muscle cell, which is essential for the support of muscle tissue and growth hormone elevation.\u003cbr\u003e\u003cbr\u003eEnter....Chain'd-Reaction® when combined with regular exercise are designed to support:\u003cbr\u003e\u003cbr\u003e • Protein Synthesis \/ Anabolism*\u003cbr\u003e • Anti-Catabolism \/ Muscle Sparing*\u003cbr\u003e • Glycogen Resynthesis*\u003cbr\u003e • Helps Preserve Lean Muscle*\u003cbr\u003e • Rebuild Muscle \u0026amp; Recover Faster*\u003cbr\u003e • Increase Growth Hormone*\u003cbr\u003e\u003cbr\u003eChain'd-Reaction® provides a tripeptide of the essential branched chain amino acids: L-Leucine, L-Isoleucine and L-Valine. During times of metabolic stress (such as high intensity exercise), BCAAs may become fuel for your muscles and help aid in protein synthesis and prevent catabolism (muscle breakdown). L-Leucine, in conjunction with exercise, may activate the mTOR pathway that supports muscle growth. To drastically increase the efficacy of BCAA delivery in Chain'd-Reaction®, these powerful, muscle building agents are continually dispersed into the muscular environment utilizing a two-pronged, sustained-release delivery mechanism that consists of APS's Micro-Rx™ and Extend-Rx™ technologies- manufacturing know-how previously beyond the scope of the sports nutrition industry. \u003cbr\u003e\u003cbr\u003eThe unique combination of these controlled dispersion, \"agglomeration-like\" technologies produces rapid disintegration of the BCAA and Glutamine compounds, whose highly micronized particles are more quickly and completely digested (without stomach upset or digestive disturbance) on their way to becoming available to the body's muscle-making machinery. Favorable Anabolic\/Anti-Catabolic changes then accelerate and enhance the uptake of BCAA's and anabolic agents, which leads to increased Protein Synthesis \/ Anabolism, Anti- Catabolism \/ Muscle Sparing, Supporting Muscle Growth and Endurance, Glycogen Resynthesis, Helps Preserve Lean Muscle, Increases Growth Hormone and Helps Rebuild Muscle \u0026amp; Recover Faster.*\u003cbr\u003e\u003cbr\u003eAdvances in Nutraceutical sports chemistry have resulted in compounds that target a variety of pathways to develop muscle mass and strength. There are now non-hormonal, highly anabolic compounds that zero-in on the juncture of protein chain assembly within muscle cells for more rapid protein synthesis. There are compounds designed to seize the \"window of opportunity\" in which muscle cells demonstrate a high affinity for the uptake of muscle-building compounds. This \"window of opportunity\" opens at the onset of intense muscular contraction and remains open until a short period immediately after training. Pre-workout supplements are designed to target the initial phase of the \"window of opportunity\" by providing muscles with compounds that allow them to sustain the level of muscular contraction required to complete a high intensity workout. Likewise, post-workout supplements target the next phase of the \"window of opportunity\" that occurs immediately after training in which depleted, wounded muscles are crying out for compounds that will replenish them with the muscle cell constituents needed to optimize recovery and promote growth of new muscle tissue. \u003cbr\u003e\u003cbr\u003eThe result is the replenishment of the key compounds that produce hydration of muscle cells. Protein synthesis is enhanced due to Amino acids being shuttled more efficiently into the muscles. These events halt protein catabolism and accelerate protein anabolism. The outcome is muscle preservation and new muscular growth. APS Nutrition speaks natural sports supplement chemistry, which means that if muscle is your game, then Chain'd-Reaction® is your real end-game!\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eAs a dietary supplement, mix 2 level scoops (12g) in 12 oz of water and mix well, 1-3 times daily.\u003c\/p\u003e"} Muscle Building Supplement Creatine Nitrate DESCRIPTION Creatine Nitrate for Revolutionary Rapid Gain Matrix For Vascularity, Strength, ATP Elevation And Recovery! Creatine Nitrate by APS is a vastly superior creatine that... DESCRIPTION Creatine Nitrate for Revolutionary Rapid Gain Matrix For Vascularity, Strength, ATP Elevation And Recovery!... SKU: APCRENIT200 Availability: In Stock $ 59.95 Add to cart Default Title Quick View {"id":435167785,"title":"Creatine Nitrate","handle":"creatine-nitrate","description":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eCreatine Nitrate for Revolutionary Rapid Gain Matrix For Vascularity, Strength, ATP Elevation And Recovery!\u003c\/h3\u003e\n\u003cp\u003eCreatine Nitrate by APS is a vastly superior creatine that has much better water solubility than any creatine thus far! You will experience full, swollen muscle bellies complimented by road map vascularity all wrapped in a tight, dry show quality package. Nitrates are the answer all physique enthusiasts have been waiting for. Not only do they make the ingredient they are bonded to more effective but they also provide more vasodilation and vascularity than ANY current Nitric Oxide\/pump product offers. In fact, nothing else even comes close. The most exciting non-hormonal muscle building, skin tearing, vein popping product to ever hit the market. Basically you have the best representation for two of the biggest categories in sports nutrition (creatine and nitric oxide) all in one bottle. This will go down as one of the biggest discoveries in sports nutrition history and for good reason. Don’t wait another day to start this revolutionary scientific breakthrough!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/Creatine-Nitrate_large.png?2604438766613356740\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eThrough a series of three clinical studies*, Creatine Nitrate was proven to be far more superior with its physio-chemical properties than its studied counterparts- -creatine monohydrate and buffered creatine. The result: nitrate compounds that break the previous barriers of solubility, stability, and dissolution, in addition to increasing bio-availability of all ingredients co-ingested.\u003c\/p\u003e\n\u003cp\u003eNitrate ion formulas are used to assist in strength development, muscular growth, and athletic performance enhancement. Nitrates, not to be confused with nitrites, are organic anions naturally occurring in the human diet, and have long been used by the medical community to increase vasodilation through actual nitric oxide production.\u003c\/p\u003e\n\u003cp\u003eAccording to a UCLA study, Creatine Nitrate is 1000% more water soluble than either Creatine Monohydrate or other creatine derivatives. Unmatched water solubility ensures better absorption and absolutely none of the traditional side effects of Creatine supplementation. You will have more energy than ever imagined possible from a supplement. You will get that extra rep, complete one more set—demolishing any previous strength, endurance, and physique personal bests.\u003c\/p\u003e\n\u003cp\u003eCreatine Nitrate by APS also contains Creatine malate, which is a creatine compound containing three creatine monohydrate molecules attached to one molecule of malic acid. Creatine monohydrate supports the production of ATP, the muscles primary source of energy in the body. Malic acid plays a supporting role as an intermediate substance that encourages energy transport to the muscles during physical activity, enhancing the Krebs cycle. Because creatine malate combines creatine monohydrate and malic acid into one formula, it can be used to promote lean body mass, muscle strength, explosiveness, endurance, focus, and overall athleticism. Creatine malate is also water-soluble, allowing for fast absorption and meaningful results.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"line-height: 1.4;\"\u003eCreatine Nitrate by APS is designed to rapidly penetrate the lipid membranes of muscle cells. \u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003eCreatine Nitrate by APS supports outstanding gains in muscle strength, stamina, and fullness. \u003c\/li\u003e\n\u003cli\u003eCreatine Nitrate by APS works at only a fraction of the dosage required with a creatine monohydrate regimen. \u003c\/li\u003e\n\u003cli\u003eCreatine Nitrate by APS helps you to increases lean muscle mass and helps you to sustain longer workouts with no loading required! \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eTake 4 capsules 40 minutes before workout and 4 capsules post workout.\u003c\/p\u003e","published_at":"2015-03-24T09:11:00-05:00","created_at":"2015-03-24T09:13:57-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":["Muscle \u0026 Strength"],"price":5995,"price_min":5995,"price_max":5995,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":1147281885,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APCRENIT200","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"Creatine Nitrate","public_title":null,"options":["Default Title"],"price":5995,"weight":227,"compare_at_price":null,"inventory_quantity":-31,"inventory_management":null,"inventory_policy":"deny","barcode":"649241909019"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/CREATINE_NITRATE.jpg?v=1512496483"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/CREATINE_NITRATE.jpg?v=1512496483","options":["Title"],"content":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eCreatine Nitrate for Revolutionary Rapid Gain Matrix For Vascularity, Strength, ATP Elevation And Recovery!\u003c\/h3\u003e\n\u003cp\u003eCreatine Nitrate by APS is a vastly superior creatine that has much better water solubility than any creatine thus far! You will experience full, swollen muscle bellies complimented by road map vascularity all wrapped in a tight, dry show quality package. Nitrates are the answer all physique enthusiasts have been waiting for. Not only do they make the ingredient they are bonded to more effective but they also provide more vasodilation and vascularity than ANY current Nitric Oxide\/pump product offers. In fact, nothing else even comes close. The most exciting non-hormonal muscle building, skin tearing, vein popping product to ever hit the market. Basically you have the best representation for two of the biggest categories in sports nutrition (creatine and nitric oxide) all in one bottle. This will go down as one of the biggest discoveries in sports nutrition history and for good reason. Don’t wait another day to start this revolutionary scientific breakthrough!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/Creatine-Nitrate_large.png?2604438766613356740\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eThrough a series of three clinical studies*, Creatine Nitrate was proven to be far more superior with its physio-chemical properties than its studied counterparts- -creatine monohydrate and buffered creatine. The result: nitrate compounds that break the previous barriers of solubility, stability, and dissolution, in addition to increasing bio-availability of all ingredients co-ingested.\u003c\/p\u003e\n\u003cp\u003eNitrate ion formulas are used to assist in strength development, muscular growth, and athletic performance enhancement. Nitrates, not to be confused with nitrites, are organic anions naturally occurring in the human diet, and have long been used by the medical community to increase vasodilation through actual nitric oxide production.\u003c\/p\u003e\n\u003cp\u003eAccording to a UCLA study, Creatine Nitrate is 1000% more water soluble than either Creatine Monohydrate or other creatine derivatives. Unmatched water solubility ensures better absorption and absolutely none of the traditional side effects of Creatine supplementation. You will have more energy than ever imagined possible from a supplement. You will get that extra rep, complete one more set—demolishing any previous strength, endurance, and physique personal bests.\u003c\/p\u003e\n\u003cp\u003eCreatine Nitrate by APS also contains Creatine malate, which is a creatine compound containing three creatine monohydrate molecules attached to one molecule of malic acid. Creatine monohydrate supports the production of ATP, the muscles primary source of energy in the body. Malic acid plays a supporting role as an intermediate substance that encourages energy transport to the muscles during physical activity, enhancing the Krebs cycle. Because creatine malate combines creatine monohydrate and malic acid into one formula, it can be used to promote lean body mass, muscle strength, explosiveness, endurance, focus, and overall athleticism. Creatine malate is also water-soluble, allowing for fast absorption and meaningful results.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"line-height: 1.4;\"\u003eCreatine Nitrate by APS is designed to rapidly penetrate the lipid membranes of muscle cells. \u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003eCreatine Nitrate by APS supports outstanding gains in muscle strength, stamina, and fullness. \u003c\/li\u003e\n\u003cli\u003eCreatine Nitrate by APS works at only a fraction of the dosage required with a creatine monohydrate regimen. \u003c\/li\u003e\n\u003cli\u003eCreatine Nitrate by APS helps you to increases lean muscle mass and helps you to sustain longer workouts with no loading required! \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eTake 4 capsules 40 minutes before workout and 4 capsules post workout.\u003c\/p\u003e"} Muscle Building Supplement HydroMax® DESCRIPTION Bodybuilders know that glycerol provides some of the most massive and engorging muscle pumps possible. HydroMax® helps increase visible vascularity by increasing blood flow... DESCRIPTION Bodybuilders know that glycerol provides some of the most massive and engorging muscle pumps... SKU: APHYDRO180 Availability: In Stock $ 39.95 Add to cart Default Title Quick View {"id":10517693133,"title":"HydroMax®","handle":"hydromax","description":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003cp\u003eBodybuilders know that glycerol provides some of the most massive and engorging muscle pumps possible. HydroMax® helps increase visible vascularity by increasing blood flow to muscles. Glycerol has been well established as a \"hyperhydrating agent\" because of its unique ability to affect blood plasma levels. Glycerol, when combined with large quantities of water, increases the amounts of fluid, minerals and other muscle building agents deeper into muscle, which increases muscle size and fullness that would otherwise be excreted. HydroMax® is super concentrated at a whopping 65%. Our proprietary blend of powdered Glycerol and Silica provides muscle hydrating effects the likes of which have never been available. Most Glycerol Monostearate (GMS) powders range from 5-12% potent and become unstable as it absorbs water. HydroMax® is easily absorbed and distributed throughout the intracellular space, increasing the concentration of fluid in the bloodstream and tissues. This creates new benefits in areas of environmental stress like crossfit and distance running but also improves blood flow associated with resistance training. Experience new growth and recovery like never before with HydroMax®.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHyper-Hydrating Muscle Agent\u003c\/li\u003e\n\u003cli\u003eIncredible Muscle Fullness\u003c\/li\u003e\n\u003cli\u003eExclusive Proprietary Blend\u003c\/li\u003e\n\u003cli\u003eIncreased Vascularity from the First Dose\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003e SUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/HYDROMAX_large.jpg?v=1501702499\" alt=\"\"\u003e\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\nTake 1 serving 1-2 times daily with 8-16oz of water or your favorite beverage twice daily. Take 30-45 minutes prior to workout. To maximize your results, drink at least 64oz of water daily while taking this product.\n\u003ch5\u003e THE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eGlycerol, when combined with large quantities of water, increases the amounts of fluid, minerals and other muscle building agents deeper into muscle which increases muscle size and fullness, that would otherwise be excreted. HydroMax® is super concentrated at a whopping 65%. Our proprietary blend of powdered Glycerol and Silica provides muscle hydrating effects the likes of which have never been available.\u003c\/p\u003e\n\u003cp\u003eBodybuilders know that glycerol provides some of the most massive and engorging muscle pumps possible. HydroMax® helps increase visible vascularity by increasing blood flow to muscles. Glycerol has been well established as a \"hyperhydrating agent\" because of its unique ability to affect blood plasma levels. Glycerol, when combined with large quantities of water, increases the amounts of fluid, minerals and other muscle building agents deeper into muscle, which increases muscle size and fullness that would otherwise be excreted.\u003c\/p\u003e\n\u003cp\u003eHydroMax® is super concentrated at a whopping 65%. Our proprietary blend of powdered Glycerol and Silica provides muscle hydrating effects the likes of which have never been available. Most Glycerol Monostearate (GMS) powders range from 5-12% potent and become unstable as it absorbs water. HydroMax® is easily absorbed and distributed throughout the intracellular space, increasing the concentration of fluid in the bloodstream and tissues. This creates new benefits in areas of environmental stress like crossfit oriented training and distance running but also improves blood flow associated with resistance training. Experience new growth and recovery like never before with HydroMax®.\u003c\/p\u003e","published_at":"2017-08-02T14:24:30-05:00","created_at":"2017-08-02T14:32:41-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":[],"price":3995,"price_min":3995,"price_max":3995,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":40975731277,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APHYDRO180","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"HydroMax®","public_title":null,"options":["Default Title"],"price":3995,"weight":113,"compare_at_price":null,"inventory_quantity":-15,"inventory_management":null,"inventory_policy":"deny","barcode":""}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/HydroMax.jpg?v=1512488311"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/HydroMax.jpg?v=1512488311","options":["Title"],"content":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003cp\u003eBodybuilders know that glycerol provides some of the most massive and engorging muscle pumps possible. HydroMax® helps increase visible vascularity by increasing blood flow to muscles. Glycerol has been well established as a \"hyperhydrating agent\" because of its unique ability to affect blood plasma levels. Glycerol, when combined with large quantities of water, increases the amounts of fluid, minerals and other muscle building agents deeper into muscle, which increases muscle size and fullness that would otherwise be excreted. HydroMax® is super concentrated at a whopping 65%. Our proprietary blend of powdered Glycerol and Silica provides muscle hydrating effects the likes of which have never been available. Most Glycerol Monostearate (GMS) powders range from 5-12% potent and become unstable as it absorbs water. HydroMax® is easily absorbed and distributed throughout the intracellular space, increasing the concentration of fluid in the bloodstream and tissues. This creates new benefits in areas of environmental stress like crossfit and distance running but also improves blood flow associated with resistance training. Experience new growth and recovery like never before with HydroMax®.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHyper-Hydrating Muscle Agent\u003c\/li\u003e\n\u003cli\u003eIncredible Muscle Fullness\u003c\/li\u003e\n\u003cli\u003eExclusive Proprietary Blend\u003c\/li\u003e\n\u003cli\u003eIncreased Vascularity from the First Dose\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003e SUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/HYDROMAX_large.jpg?v=1501702499\" alt=\"\"\u003e\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\nTake 1 serving 1-2 times daily with 8-16oz of water or your favorite beverage twice daily. Take 30-45 minutes prior to workout. To maximize your results, drink at least 64oz of water daily while taking this product.\n\u003ch5\u003e THE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eGlycerol, when combined with large quantities of water, increases the amounts of fluid, minerals and other muscle building agents deeper into muscle which increases muscle size and fullness, that would otherwise be excreted. HydroMax® is super concentrated at a whopping 65%. Our proprietary blend of powdered Glycerol and Silica provides muscle hydrating effects the likes of which have never been available.\u003c\/p\u003e\n\u003cp\u003eBodybuilders know that glycerol provides some of the most massive and engorging muscle pumps possible. HydroMax® helps increase visible vascularity by increasing blood flow to muscles. Glycerol has been well established as a \"hyperhydrating agent\" because of its unique ability to affect blood plasma levels. Glycerol, when combined with large quantities of water, increases the amounts of fluid, minerals and other muscle building agents deeper into muscle, which increases muscle size and fullness that would otherwise be excreted.\u003c\/p\u003e\n\u003cp\u003eHydroMax® is super concentrated at a whopping 65%. Our proprietary blend of powdered Glycerol and Silica provides muscle hydrating effects the likes of which have never been available. Most Glycerol Monostearate (GMS) powders range from 5-12% potent and become unstable as it absorbs water. HydroMax® is easily absorbed and distributed throughout the intracellular space, increasing the concentration of fluid in the bloodstream and tissues. This creates new benefits in areas of environmental stress like crossfit oriented training and distance running but also improves blood flow associated with resistance training. Experience new growth and recovery like never before with HydroMax®.\u003c\/p\u003e"} Muscle Building Supplement IGF-1 Extreme™ DESCRIPTION IGF-1 Xtreme™ - The #1 IGF-1 (Insulin Growth Factor-1) and Deer Antler Product on the Market! APS Insulin Growth Factor-1 Xtreme™ is a growth... DESCRIPTION IGF-1 Xtreme™ - The #1 IGF-1 (Insulin Growth Factor-1) and Deer Antler Product on... SKU: APIGF60 Availability: In Stock $ 59.95 Add to cart Default Title Quick View {"id":1524178305,"title":"IGF-1 Extreme™","handle":"igf-1-extreme","description":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eIGF-1 Xtreme™ - The #1 IGF-1 (Insulin Growth Factor-1) and Deer Antler Product on the Market!\u003c\/h3\u003e\n\u003cp\u003eAPS Insulin Growth Factor-1 Xtreme™ is a growth factor which is very closely related to insulin. It carries the same amount of amino acids as insulin and responsible for the anabolic reactions to GH. IGF-1 is highly anabolic in adults and can help build lean muscle and help recovery times from grueling workouts. APS Insulin Growth Factor-1 Xtreme with Deer Antler has been traditionally used for muscle strength and increased athletic performance, post workout recovery, anti-aging, improved sexual performance for men and women, joint support, and immune system operation. APS IGF-1 Xtreme™ contains 100mg Deer Antler Velvet Extract (30 to 100 times more than the competition) and is harvested from the antlers of growing deer, moose, caribou, and elk prior to hardening, with no harm to the animal. Deer Antler is a potent source of IGF-1, a growth hormone beneficial to muscle, nerve, and cell repair.\u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/IGF-1-Xtreme.jpg?4338705107258474089\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eIGF-1 is released in the liver and binds to the IGF receptors within the cells, which ultimately causes a stimulation of cell growth (both causing new tissue formation and existing tissue growth) and an inhibition of cell death. It is a highly anabolic and anti-catabolic compound. For the athlete or bodybuilder, this had many positive effects: increased nitrogen retention and protein synthesis because it is highly anabolic. IGF-1 (in the presence of sufficient protein) actually promotes growth of new muscle cells, which increases the overall number of cells in the muscle. IGF-1 is also responsible in connective tissue production, improves collagen formation and aids in cartilage repair.\u003c\/p\u003e\n\u003cp\u003eIn a study done on young adult mice, a compound responsible for increased secretion of IGF-1 in muscle fibers was administered. There was an average increase of 15% in muscle mass and a 14% increase in strength. When the study was then conducted on adult mice, there was a 27% increase in strength in the injected muscles as compared with non-injected muscles. It was also found to prevent aging of the muscles. Muscle mass and muscle fiber growth were similar to the levels found in young adults. These effects are most likely due to the ability of IGF-1 to activate satellite cells, therefore stimulating muscle rejuvenation.\u003c\/p\u003e\n\u003cp\u003eIGF-1 transports glucose and amino acids into muscle while stimulating muscle DNA. This results in a muscular development in youth and muscle preservation in old age. For the athlete it means peak performance and quick recovery from intense training or injury. Other tissues of the body benefit from IGF-1 because of the affect on DNA and RNA (Ribonucleic Acid and Deoxyribonucleic Acid - are nucleic acids that are an essential part of every living cell). This tends to stimulate a faster production of proteins such as enzymes that help conduct normal metabolism.\u003c\/p\u003e\n\u003cp\u003eMale Deer grow new antlers every year just before mating season. Before they harden, these antlers are velvety and cartilaginous replete with nerves and blood vessels. This amazing growth spurt happens in just a couple of months. The incredible growth and cellular repair that occurs during deer antler creation is the factor that pointed research scientists in the direction of discovering what would eventually be a wide array of applicable benefits in human biochemistry. The biochemical extract from deer velvet produces an Insulin-like Growth Hormone that is uniquely powerful. In testing this biochemical agent, scientists have found that nerve repair and cellular integrity are vastly improved by the introduction of this chemical.\u003c\/p\u003e\n\u003cp\u003eMale Deer Antler also contains compounds that are necessary for overall wellness, such as amino acids, prostaglandin, iron, zinc, copper, manganese, selenium, calcium, magnesium, potassium, sodium, sulfur, and phosphorus. Also found in Deer Antler are glucosamine and chondroitin, which support healthy joint functions. Cellular repair and integrity is especially important in keeping one’s immune system at its highest level. The rigors of a workout regimen can cause one’s immune system to suffer otherwise. This means faster healing of the micro tears in muscle tissue that result from exertion which translates into less downtime after those especially tough workouts when you’re preparing for competitive athleticism.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eAPS IGF-1 Xtreme™ Utilizes a Proprietary, Highly Bioavailable form of 80% Colostrum with IGF-1 Growth Factors!\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eAPS IGF-1 Xtreme™ utilizes the purest form of Colostrum on the market and is a highly-concentrated source of powerful immune and growth factors and as a nutritional supplement, bovine colostrum provides exceptional, synergistic support. APS colostrum is 200-400% stronger than any other version on the market! Immunoglobins, the most abundant types of immune factors in colostrum, are large protein molecules that include Immunoglobins G (IgG), A (IgA), E (IgE), D (IgD), and M (IgM). APS Colostrum 80% also contains extremely high levels of proline-rich polypeptide (PRP's) and proteins to help aid in recovery and immune health. Each has a specific role in natural defense, including activation of various immune cells. IgG is found in the highest concentration and helps to neutralize toxins. Proline-rich Polypeptide (PRP) is a hormone produced by the thymus gland to help balance and activate the immune response. Growth factors include insulin growth factors (IGF-1 and IGF-2) and transforming growth factors (TGF-A and TGF-B). These growth factors, identical in composition to human growth factors, have the potential to enhance immune cell function and to nutritionally support healthy connective and nerve tissues in the body. Furthermore, growth factors promote glucose metabolism for fuel, support protein synthesis, and help maintain lean muscle. This supports healthy body composition and has demonstrated the ability to enhance speed and strength training. In fact, many world-class athletes are known to take it regularly. The reason it is receiving so much attention lately is due to the rapidly growing body of clinical evidence that demonstrates how it can support athletic performance.\u003c\/p\u003e\n\u003cp\u003eWhat can athletes expect from APS 80% colostrum? The IGF-1 in colostrum increases uptake of blood glucose and facilitates the transport of glucose to the muscles, which keeps energy levels up. Together with growth hormones, IGF-1 also slows the rate of protein breakdown (catabolism) that occurs after a vigorous workout. It speeds up protein synthesis, which results in lean muscle mass without an increase in the amount of stored fat. Colostrum improves the assimilation of nutrients, which leads to improved energy levels and performance. APS Colostrum is manufactured exclusively from USDA Grade A dairies, and only from the first milking, is laboratory tested to verify that it is free from hormones, pesticides, antibiotics and rBHT. A truly natural product; Also, the immune factors in colostrum help athletes to minimize their susceptibility to infections while being able to keep up with their intense training schedules. Colostrum could be the most important natural substance to help athletes (from weekend warriors to professional athletes) achieve their desired results. Research shows that colostrum can help: Increase strength and endurance, Build lean muscle mass, Shorten recovery time and Accelerate healing of injuries from grueling physical activity.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003ePerformance: Strength, Endurance \u0026amp; Build Muscle\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eRecent research shows that bovine colostrum supplementation can improve performance in activities requiring both strength and endurance. An study compared the effect of bovine colostrum supplementation during training significantly increased peak anaerobic power. Colostrum contains the growth factors that help build lean muscle, including insulin-like growth factors (IGF-I \u0026amp; IGF-II) and growth hormone (GH). IGF-I, which is found naturally in colostrum, is the only natural hormone capable of promoting muscle growth by itself. The IGFs in humans and cows are identical, but bovine colostrum actually contains a greater concentration of IGF-I than human colostrum. This fact makes bovine colostrum attractive to bodybuilders, athletes and others seeking to gain muscle mass. According to a study conducted in Finland, IGF-1 induces protein synthesis, which leads to an increase in lean muscle mass without a corresponding rise in adipose (fat) tissue. Recent studies have tracked the effect of colostrum on athletic performance. These studies showed that colostrum supplementation results in much shorter recovery times following maximal exercise, as well as significantly increased anaerobic power!\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eAdvanced Delivery System Provides Better Absorption\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eIn the last decades, the growth of nanotechnology has opened several new possibilities in medical sciences, especially in the field of drug delivery. Different new drug carrier systems in the micro- and nanometer size range have been developed and the number of patents and products in the drug delivery field has increased tremendously. Nanoparticles are solid colloidal particles ranging in size from about 10 nm to 1000 nm. The major goal in designing nanoparticles as a delivery system is to control particle size, surface properties, and release of pharmacologically active agents in order to achieve the site-specific action of drugs at a therapeutically optimal rate and dosage regimen. Most of the nanoparticles in IGF-1 Xtreme™ were micronized by a special machine only pharmaceutical companies have, due to its cost, to between 20 nm to 100 nm. IGF-1 Xtreme™ utilized site-specific drug delivery to enable the Insulin Growth Factor-1 nanoparticles to be delivered directly into the lymphatic system. The nanocarriers were engineered to have a prolonged circulation time and to have enhanced cellular uptake and targeting abilities.\u003c\/p\u003e\n\u003cp\u003eAPS utilized 97% pure Hydrolyzed Gelatin protein which is one of the proteinaceous materials that can be used for the production of nanoparticles. It is one of the most widely used animal proteins obtained by controlled hydrolysis of collagen, which is a major component of the skin, bones, and connective tissues . Gelatin is generally regarded as a safe (GRAS) excipient approved by the United States FDA for use in pharmaceutical preparations such as gelatin capsules. It is nontoxic and easy to be cross-linked or modified chemically. Therefore, it had the best potential to be used for the preparation of the IGF-1 Xtreme™ delivery systems nanoparticles. A key characteristic of gelatin is its high content of amino acids glycine, proline (mainly as hydroxyproline), and alanine. Most gelatin molecules contain repeating sequences of glycine, proline, and alanine triplets, which are responsible for the triple helical structure of gelatin. Addition of chemical crosslinking agents gives gelatin stability, shape, and increased circulation time as compared to unmodified gelatin. APS researchers understood the release of Insulin Growth Factor-1 from gelatin nanoparticles is dependent on the degree of crosslinking. Such crosslinking improves the integrity and performance of gelatin such as insolubility at high temperatures and reduced swelling in water.\u003c\/p\u003e\n\u003cp\u003eAPS IGF-1 Xtreme™ utilizes an exclusive, proprietary and novel delivery system that combined complimentary properties of liposomes and the polymeric nanoparticles described above (e.g. nanolipobeads represent a new trend in the application of site specific target compound delivery). The problem with most liquid deer antler or IGF-1 products on the market is that they are not bioavailable and do not allow you to see the amazing benefits of IGF-1. APS unique preparation of nanolipobeads involves three steps —\u003c\/p\u003e\n\u003cp\u003e(a) Preparation of PVA and hydrolyzed gelatin hydrogel nanopartices by emulsification followed by freeze thaw cyclization method.\u003c\/p\u003e\n\u003cp\u003e(b) Surface acylation of PVA nanoparticles by treatment with polmityl chloride and;\u003c\/p\u003e\n\u003cp\u003e(c) Preparation of nanolipobeads by formation of PE liposome on acylated PVA hydrogel nanoparticles by vesicles fusion.The Preparation of PVA hydrogel nanopartices is then optimized by various formulation and process variables (e.g. polymer concentrations, drug concentration, emulsifier concentrations, and a number of freeze thaw cycles, stirring speed, stirring time, and sonication time to obtain nanosized PVA hydrogel nanoparticles with maximum entrapment efficiency.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThis scientifically-engineered delivery system allows APS IGF-1 Xtreme™ with Deer Antler to be delivered into the blood stream more rapidly to get the powerful benefits from Insulin Growth Factor-1 , where they can be better absorbed and utilized without degradation in the liver as is experienced with most other products. Since APS IGF-1 Xtreme™ offers a novel proprietary delivery system — more research needs to be conducted to determine if the enhanced results seen by people who have used it are due to the delivery system and\/ or the more potent growth factors. APS Researchers a preliminary findings show this technology can increase the absorption and bioavailability of the colostrum by up to 800%! This enhanced delivery system to get more Insulin Growth Factor-1 into the bloodstream helps to shorten catabolism (the breaking down of muscle), and get the body back into an anabolic state more quickly after a workout.\u003c\/p\u003e\n\u003cp\u003eAll the technology above insures all of APS IGF-1 Xtreme™ and its ability to harness the power of Insulin Growth Factor-1 Xtreme from Deer Antler and colostrum's unique anabolic\/anti-catabolic components not only survive, but are biologically active. Research has shown that most colostrum and IGF-1 is degraded and mostly destroyed by human stomach acids and digestive enzymes. To insure that APS IGF-1 Xtreme™ with Deer Antler and colostrum would make it into the GI tract APS developed the technology bove to provide a special delivery system that protects the active ingredients so they can survive the stomach passage intact and improve their absorption of Insulin Growth Factor-1 into the blood stream for significantly enhanced performance.\u003c\/p\u003e\n\u003cp\u003eAPS IGF-1 Xtreme™ also only uses Deer Antler that is derived from cold processed, concentrated Conu parvum deer velvet antler grown in New Zealand. APS IGF-1 Xtreme™ holds the worldwide rights to this unique product and advanced technology protein\/peptide delivery system and is in the process of getting a patent for the above technology.\u003c\/p\u003e\n\u003cp\u003eIn studies conducted where GH and IGF1 were used together, a greater increase of Lean Body Mass was found than by use with each compound alone. APS' researchers and scientists also believe that use of testosterone or a product like Androbolic 250 or Test Suspension and\/or Revivarent G along with Insulin Growth Factor-1 Xtreme™ would be a great stack to increase IGF levels in muscle.\u003c\/p\u003e\n\u003cbr\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eAs a dietary supplement, take one or two capsules two times daily on an empty stomach. Take 8-12 hours apart. \u003c\/p\u003e","published_at":"2015-07-14T09:47:00-05:00","created_at":"2015-07-14T09:49:44-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":["Add Muscle","Muscle \u0026 Strength"],"price":5995,"price_min":5995,"price_max":5995,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":4613267457,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APIGF60","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"IGF-1 Extreme™","public_title":null,"options":["Default Title"],"price":5995,"weight":113,"compare_at_price":null,"inventory_quantity":-75,"inventory_management":null,"inventory_policy":"deny","barcode":"649241899945"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/IGF1.jpg?v=1512488350"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/IGF1.jpg?v=1512488350","options":["Title"],"content":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eIGF-1 Xtreme™ - The #1 IGF-1 (Insulin Growth Factor-1) and Deer Antler Product on the Market!\u003c\/h3\u003e\n\u003cp\u003eAPS Insulin Growth Factor-1 Xtreme™ is a growth factor which is very closely related to insulin. It carries the same amount of amino acids as insulin and responsible for the anabolic reactions to GH. IGF-1 is highly anabolic in adults and can help build lean muscle and help recovery times from grueling workouts. APS Insulin Growth Factor-1 Xtreme with Deer Antler has been traditionally used for muscle strength and increased athletic performance, post workout recovery, anti-aging, improved sexual performance for men and women, joint support, and immune system operation. APS IGF-1 Xtreme™ contains 100mg Deer Antler Velvet Extract (30 to 100 times more than the competition) and is harvested from the antlers of growing deer, moose, caribou, and elk prior to hardening, with no harm to the animal. Deer Antler is a potent source of IGF-1, a growth hormone beneficial to muscle, nerve, and cell repair.\u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/IGF-1-Xtreme.jpg?4338705107258474089\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eIGF-1 is released in the liver and binds to the IGF receptors within the cells, which ultimately causes a stimulation of cell growth (both causing new tissue formation and existing tissue growth) and an inhibition of cell death. It is a highly anabolic and anti-catabolic compound. For the athlete or bodybuilder, this had many positive effects: increased nitrogen retention and protein synthesis because it is highly anabolic. IGF-1 (in the presence of sufficient protein) actually promotes growth of new muscle cells, which increases the overall number of cells in the muscle. IGF-1 is also responsible in connective tissue production, improves collagen formation and aids in cartilage repair.\u003c\/p\u003e\n\u003cp\u003eIn a study done on young adult mice, a compound responsible for increased secretion of IGF-1 in muscle fibers was administered. There was an average increase of 15% in muscle mass and a 14% increase in strength. When the study was then conducted on adult mice, there was a 27% increase in strength in the injected muscles as compared with non-injected muscles. It was also found to prevent aging of the muscles. Muscle mass and muscle fiber growth were similar to the levels found in young adults. These effects are most likely due to the ability of IGF-1 to activate satellite cells, therefore stimulating muscle rejuvenation.\u003c\/p\u003e\n\u003cp\u003eIGF-1 transports glucose and amino acids into muscle while stimulating muscle DNA. This results in a muscular development in youth and muscle preservation in old age. For the athlete it means peak performance and quick recovery from intense training or injury. Other tissues of the body benefit from IGF-1 because of the affect on DNA and RNA (Ribonucleic Acid and Deoxyribonucleic Acid - are nucleic acids that are an essential part of every living cell). This tends to stimulate a faster production of proteins such as enzymes that help conduct normal metabolism.\u003c\/p\u003e\n\u003cp\u003eMale Deer grow new antlers every year just before mating season. Before they harden, these antlers are velvety and cartilaginous replete with nerves and blood vessels. This amazing growth spurt happens in just a couple of months. The incredible growth and cellular repair that occurs during deer antler creation is the factor that pointed research scientists in the direction of discovering what would eventually be a wide array of applicable benefits in human biochemistry. The biochemical extract from deer velvet produces an Insulin-like Growth Hormone that is uniquely powerful. In testing this biochemical agent, scientists have found that nerve repair and cellular integrity are vastly improved by the introduction of this chemical.\u003c\/p\u003e\n\u003cp\u003eMale Deer Antler also contains compounds that are necessary for overall wellness, such as amino acids, prostaglandin, iron, zinc, copper, manganese, selenium, calcium, magnesium, potassium, sodium, sulfur, and phosphorus. Also found in Deer Antler are glucosamine and chondroitin, which support healthy joint functions. Cellular repair and integrity is especially important in keeping one’s immune system at its highest level. The rigors of a workout regimen can cause one’s immune system to suffer otherwise. This means faster healing of the micro tears in muscle tissue that result from exertion which translates into less downtime after those especially tough workouts when you’re preparing for competitive athleticism.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eAPS IGF-1 Xtreme™ Utilizes a Proprietary, Highly Bioavailable form of 80% Colostrum with IGF-1 Growth Factors!\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eAPS IGF-1 Xtreme™ utilizes the purest form of Colostrum on the market and is a highly-concentrated source of powerful immune and growth factors and as a nutritional supplement, bovine colostrum provides exceptional, synergistic support. APS colostrum is 200-400% stronger than any other version on the market! Immunoglobins, the most abundant types of immune factors in colostrum, are large protein molecules that include Immunoglobins G (IgG), A (IgA), E (IgE), D (IgD), and M (IgM). APS Colostrum 80% also contains extremely high levels of proline-rich polypeptide (PRP's) and proteins to help aid in recovery and immune health. Each has a specific role in natural defense, including activation of various immune cells. IgG is found in the highest concentration and helps to neutralize toxins. Proline-rich Polypeptide (PRP) is a hormone produced by the thymus gland to help balance and activate the immune response. Growth factors include insulin growth factors (IGF-1 and IGF-2) and transforming growth factors (TGF-A and TGF-B). These growth factors, identical in composition to human growth factors, have the potential to enhance immune cell function and to nutritionally support healthy connective and nerve tissues in the body. Furthermore, growth factors promote glucose metabolism for fuel, support protein synthesis, and help maintain lean muscle. This supports healthy body composition and has demonstrated the ability to enhance speed and strength training. In fact, many world-class athletes are known to take it regularly. The reason it is receiving so much attention lately is due to the rapidly growing body of clinical evidence that demonstrates how it can support athletic performance.\u003c\/p\u003e\n\u003cp\u003eWhat can athletes expect from APS 80% colostrum? The IGF-1 in colostrum increases uptake of blood glucose and facilitates the transport of glucose to the muscles, which keeps energy levels up. Together with growth hormones, IGF-1 also slows the rate of protein breakdown (catabolism) that occurs after a vigorous workout. It speeds up protein synthesis, which results in lean muscle mass without an increase in the amount of stored fat. Colostrum improves the assimilation of nutrients, which leads to improved energy levels and performance. APS Colostrum is manufactured exclusively from USDA Grade A dairies, and only from the first milking, is laboratory tested to verify that it is free from hormones, pesticides, antibiotics and rBHT. A truly natural product; Also, the immune factors in colostrum help athletes to minimize their susceptibility to infections while being able to keep up with their intense training schedules. Colostrum could be the most important natural substance to help athletes (from weekend warriors to professional athletes) achieve their desired results. Research shows that colostrum can help: Increase strength and endurance, Build lean muscle mass, Shorten recovery time and Accelerate healing of injuries from grueling physical activity.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003ePerformance: Strength, Endurance \u0026amp; Build Muscle\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eRecent research shows that bovine colostrum supplementation can improve performance in activities requiring both strength and endurance. An study compared the effect of bovine colostrum supplementation during training significantly increased peak anaerobic power. Colostrum contains the growth factors that help build lean muscle, including insulin-like growth factors (IGF-I \u0026amp; IGF-II) and growth hormone (GH). IGF-I, which is found naturally in colostrum, is the only natural hormone capable of promoting muscle growth by itself. The IGFs in humans and cows are identical, but bovine colostrum actually contains a greater concentration of IGF-I than human colostrum. This fact makes bovine colostrum attractive to bodybuilders, athletes and others seeking to gain muscle mass. According to a study conducted in Finland, IGF-1 induces protein synthesis, which leads to an increase in lean muscle mass without a corresponding rise in adipose (fat) tissue. Recent studies have tracked the effect of colostrum on athletic performance. These studies showed that colostrum supplementation results in much shorter recovery times following maximal exercise, as well as significantly increased anaerobic power!\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eAdvanced Delivery System Provides Better Absorption\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eIn the last decades, the growth of nanotechnology has opened several new possibilities in medical sciences, especially in the field of drug delivery. Different new drug carrier systems in the micro- and nanometer size range have been developed and the number of patents and products in the drug delivery field has increased tremendously. Nanoparticles are solid colloidal particles ranging in size from about 10 nm to 1000 nm. The major goal in designing nanoparticles as a delivery system is to control particle size, surface properties, and release of pharmacologically active agents in order to achieve the site-specific action of drugs at a therapeutically optimal rate and dosage regimen. Most of the nanoparticles in IGF-1 Xtreme™ were micronized by a special machine only pharmaceutical companies have, due to its cost, to between 20 nm to 100 nm. IGF-1 Xtreme™ utilized site-specific drug delivery to enable the Insulin Growth Factor-1 nanoparticles to be delivered directly into the lymphatic system. The nanocarriers were engineered to have a prolonged circulation time and to have enhanced cellular uptake and targeting abilities.\u003c\/p\u003e\n\u003cp\u003eAPS utilized 97% pure Hydrolyzed Gelatin protein which is one of the proteinaceous materials that can be used for the production of nanoparticles. It is one of the most widely used animal proteins obtained by controlled hydrolysis of collagen, which is a major component of the skin, bones, and connective tissues . Gelatin is generally regarded as a safe (GRAS) excipient approved by the United States FDA for use in pharmaceutical preparations such as gelatin capsules. It is nontoxic and easy to be cross-linked or modified chemically. Therefore, it had the best potential to be used for the preparation of the IGF-1 Xtreme™ delivery systems nanoparticles. A key characteristic of gelatin is its high content of amino acids glycine, proline (mainly as hydroxyproline), and alanine. Most gelatin molecules contain repeating sequences of glycine, proline, and alanine triplets, which are responsible for the triple helical structure of gelatin. Addition of chemical crosslinking agents gives gelatin stability, shape, and increased circulation time as compared to unmodified gelatin. APS researchers understood the release of Insulin Growth Factor-1 from gelatin nanoparticles is dependent on the degree of crosslinking. Such crosslinking improves the integrity and performance of gelatin such as insolubility at high temperatures and reduced swelling in water.\u003c\/p\u003e\n\u003cp\u003eAPS IGF-1 Xtreme™ utilizes an exclusive, proprietary and novel delivery system that combined complimentary properties of liposomes and the polymeric nanoparticles described above (e.g. nanolipobeads represent a new trend in the application of site specific target compound delivery). The problem with most liquid deer antler or IGF-1 products on the market is that they are not bioavailable and do not allow you to see the amazing benefits of IGF-1. APS unique preparation of nanolipobeads involves three steps —\u003c\/p\u003e\n\u003cp\u003e(a) Preparation of PVA and hydrolyzed gelatin hydrogel nanopartices by emulsification followed by freeze thaw cyclization method.\u003c\/p\u003e\n\u003cp\u003e(b) Surface acylation of PVA nanoparticles by treatment with polmityl chloride and;\u003c\/p\u003e\n\u003cp\u003e(c) Preparation of nanolipobeads by formation of PE liposome on acylated PVA hydrogel nanoparticles by vesicles fusion.The Preparation of PVA hydrogel nanopartices is then optimized by various formulation and process variables (e.g. polymer concentrations, drug concentration, emulsifier concentrations, and a number of freeze thaw cycles, stirring speed, stirring time, and sonication time to obtain nanosized PVA hydrogel nanoparticles with maximum entrapment efficiency.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThis scientifically-engineered delivery system allows APS IGF-1 Xtreme™ with Deer Antler to be delivered into the blood stream more rapidly to get the powerful benefits from Insulin Growth Factor-1 , where they can be better absorbed and utilized without degradation in the liver as is experienced with most other products. Since APS IGF-1 Xtreme™ offers a novel proprietary delivery system — more research needs to be conducted to determine if the enhanced results seen by people who have used it are due to the delivery system and\/ or the more potent growth factors. APS Researchers a preliminary findings show this technology can increase the absorption and bioavailability of the colostrum by up to 800%! This enhanced delivery system to get more Insulin Growth Factor-1 into the bloodstream helps to shorten catabolism (the breaking down of muscle), and get the body back into an anabolic state more quickly after a workout.\u003c\/p\u003e\n\u003cp\u003eAll the technology above insures all of APS IGF-1 Xtreme™ and its ability to harness the power of Insulin Growth Factor-1 Xtreme from Deer Antler and colostrum's unique anabolic\/anti-catabolic components not only survive, but are biologically active. Research has shown that most colostrum and IGF-1 is degraded and mostly destroyed by human stomach acids and digestive enzymes. To insure that APS IGF-1 Xtreme™ with Deer Antler and colostrum would make it into the GI tract APS developed the technology bove to provide a special delivery system that protects the active ingredients so they can survive the stomach passage intact and improve their absorption of Insulin Growth Factor-1 into the blood stream for significantly enhanced performance.\u003c\/p\u003e\n\u003cp\u003eAPS IGF-1 Xtreme™ also only uses Deer Antler that is derived from cold processed, concentrated Conu parvum deer velvet antler grown in New Zealand. APS IGF-1 Xtreme™ holds the worldwide rights to this unique product and advanced technology protein\/peptide delivery system and is in the process of getting a patent for the above technology.\u003c\/p\u003e\n\u003cp\u003eIn studies conducted where GH and IGF1 were used together, a greater increase of Lean Body Mass was found than by use with each compound alone. APS' researchers and scientists also believe that use of testosterone or a product like Androbolic 250 or Test Suspension and\/or Revivarent G along with Insulin Growth Factor-1 Xtreme™ would be a great stack to increase IGF levels in muscle.\u003c\/p\u003e\n\u003cbr\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eAs a dietary supplement, take one or two capsules two times daily on an empty stomach. Take 8-12 hours apart. \u003c\/p\u003e"} FeaturedProduct Plasmagen Nitrate® Muscle Building Supplement $ 69.95 Already Sold: 972 Hurry Up! Offer ends in: Muscle Building Supplement Androbolic 250™ SUPPLEMENT FACTS SUGGESTED USE As a dietary supplement, take 2 tablets once or twice daily on an empty stomach. Take 8-12 hours apart. Do... SUPPLEMENT FACTS SUGGESTED USE As a dietary supplement, take 2 tablets once or twice... SKU: APAND60 Availability: Temporarily Out of Stock Coming Soon Add to cart Quick View {"id":1693045825,"title":"Androbolic 250™","handle":"androbolic-250","description":"\u003cbr\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/andro250_large.png?1324308203357910403\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\nSUGGESTED USE\n\u003cp\u003eAs a dietary supplement, take 2 tablets once or twice daily on an empty stomach. Take 8-12 hours apart. Do not exceed 4 tablets per day.\u003c\/p\u003e","published_at":"2015-06-25T16:51:00-05:00","created_at":"2015-07-28T14:18:33-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":["Add Muscle","Muscle \u0026 Strength","Testosterone Support"],"price":7995,"price_min":7995,"price_max":7995,"available":false,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":5113234049,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APAND60","requires_shipping":true,"taxable":false,"featured_image":null,"available":false,"name":"Androbolic 250™","public_title":null,"options":["Default Title"],"price":7995,"weight":227,"compare_at_price":null,"inventory_quantity":0,"inventory_management":"shopify","inventory_policy":"deny","barcode":"649241899969"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/ANDROBOLIC250.jpg?v=1512488248"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/ANDROBOLIC250.jpg?v=1512488248","options":["Title"],"content":"\u003cbr\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/andro250_large.png?1324308203357910403\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\nSUGGESTED USE\n\u003cp\u003eAs a dietary supplement, take 2 tablets once or twice daily on an empty stomach. Take 8-12 hours apart. Do not exceed 4 tablets per day.\u003c\/p\u003e"} Muscle Building Supplement Arimigen™ DESCRIPTION Arimigen™ Supports Decrease of Estrogen & Increase of Testosterone Levels!* Arimigen™ — APS Nutrition's novel Aromatase Inhibitor is a new ground breaking formula designed... DESCRIPTION Arimigen™ Supports Decrease of Estrogen & Increase of Testosterone Levels!* Arimigen™ — APS Nutrition's... SKU: APARI60 Availability: Temporarily Out of Stock Coming Soon Add to cart Quick View {"id":1693157825,"title":"Arimigen™","handle":"arimigen","description":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eArimigen\u003c\/strong\u003e\u003cstrong\u003e™\u003c\/strong\u003e \u003cstrong\u003eSupports Decrease of Estrogen \u0026amp; Increase of Testosterone Levels!* \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eArimigen™ — APS Nutrition's novel Aromatase Inhibitor is a new ground breaking formula designed to optimize an anabolic environment by decreasing estrogen and increasing testosterone levels. Arimigen™ is a multi-pathway formulation that minimizes or eliminates the undesirable effects associated with an estrogen dominant environment. Arimigen™ maintains the correct testosterone to estrogen ratios that yield the benefits associated with normal estrogen levels. Arimigen™ acts as an anti-aromatase agent and is thus a powerful elevator of total testosterone and maximum liberator of free testosterone. This one-of-a- kind formulation is exclusively manufactured by APS and aggressively combats heightened estrogen levels that can come with elevated testosterone. *\u003c\/p\u003e\n\u003cbr\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/arimigen_large.png?10323656229900534673\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eArimigen™ allows the user to get the anabolic benefits of increased testosterone levels without the negative side-effects of estrogen (the downside of elevated testosterone), water retention and unattractive body-weight accumulation that usually accompany elevated levels of testosterone in the body. Arimigen™ is appropriately used when using substantial amounts of aromatizing hormones or prohormones. Arimigen™ also works by metabolizing active estrogens into inactive estrogen metabolites, blocking estrogen at the actual estrogen receptor site in male breast tissue, and by freeing excess estrogen from the body. Arimigen™ also will help to down regulate SHBG (Sex hormone-binding globulin) and therefore known to support increased FREE testosterone levels.\u003c\/p\u003e\n\u003cp\u003eThe Arimigen™ proprietary formula was developed by combining naturally occurring aromatase inhibitors and inhibitors of the action of SHBG. The dietary supplement Arimigen™ is a multi-pathway agent that exerts its influence by blocking various stages in the aromatase process and by inhibiting SHBG's action; an activity not clearly addressed by any of the aromatase inhibiting or anti-estrogen products. Further, it appears that use of Arimigen™ may result in long-term blocking of selective anabolic estrogen receptors and\/or inhibition of selective estrogen signaling. This activity has not been addressed by any known dietary supplements or pharmacological agents. \u003c\/p\u003e\n\u003cp\u003eArimigen™ acts as an Elevator of total testosterone and liberator of free testosterone. As a powerful aromatase inhibitor, Arimigen™ also possesses notable testosterone stimulating properties. The aromatase inhibiting action reduces the signal that estrogen sends to the brain to suppress endogenous testosterone production (estrogen is a main feedback signal to control the release of testosterone, thus increasing the testicular output of testosterone). Arimigen™ thus assists in resetting the body's level of its own natural testosterone production by regulating the activity of the hypothalamic-pituitary-testicular axis (HPTA), which constantly adjusts the body's production of testosterone to maintain target blood levels. Continued use of Arimigen™ results in not only a significant reduction in the production of estrogen, but also a corresponding substantial increase in endogenous testosterone. Only Arimigen™ addresses all possible channels to estrogen maintenance and free testosterone elevation, which means optimal hormonal levels for muscle building and dry, hard physique.\u003c\/p\u003e\n\u003cp\u003eArimigen™ is based primarily on the testosterone, LH, FSH, libido and lean mass extreme stimulatory compound referred to as ‘Akarkara’ in Anacyclus pyrethrum, the information has been widely recognized in the Ayurvedic system of Indian medicine for over 2 centuries. Not a “discovery” for us, more of an advanced understanding was accomplished with patience on our part. Our testing, research and patience paid off by allowing us to release of Arimigen™ with a multi-independent study validated extract that \u003cstrong\u003eoutperformed the other common extract on the market by over 71% for mass gain!\u003c\/strong\u003e Arimigen™ also contains a \"supporting cast\" of ingredients that have individually been shown to support inhibition of excessive estrogen formation that make Arimigen™ truly revolutionary.\u003c\/p\u003e\n\u003cp\u003eThe first of these ingredients is an extract derived from the leaves of Brassaiopsis glomerulata (standardized to 6ß-hydroxystimasta-4- en-3-one and N-benzoyl-L-phenylalanine methyl ester). APS’s unique extraction process of this plant results an extract that produce 13 isolated estrogen-modulating compounds.\u003c\/p\u003e\n\u003cp\u003eAs mentioned above, the attractive effect of Brassaiopsis glomerulata extract is due to its aromatase inhibition property. Aromatase is the enzyme responsible for catalyzing the last steps of biosynthesis of estrogens (estrone and estradiol) from androgens (androstenedione and testosterone). Inhibition of aromatase has been shown to reduce estrogen production throughout the body to nearly undetectable levels.\u003c\/p\u003e\n\u003cp\u003e\u003cimg width=\"411\" height=\"83\" style=\"float: right;\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/ARIMIGEN_09c86494-ddcc-4f62-bb5f-d0f34123edb8.png?4199550805568428710\"\u003eBodybuilders that take anabolic ingredients often use aromatase inhibitors in order to minimize or avoid estrogenic effects. Aromatase inhibitors can prevent elevated levels of testosterone from being converted to excess estrogen and have also been shown to reverse age-related decline in testosterone.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eArimigen™ also contains a 98% highly purified version of Chrysin (5,7-dihydroxyflavone) which is the name of a monoflavone extracted from a plant called \"Passiflora caerulea\". Flavones, a group of compounds found in many different plants, are known to have numerous therapeutic effects. Of all the unique biological activities, Chrysin has generated the most interest as an aromatase inhibitor, which has also been shown to control estrogen through modulation of estrogen metabolism. In the May ’96 issue of \u003cem\u003eMuscle Media 2000\u003c\/em\u003e, the late Dan Duchaine, known as the “steroid guru,” discussed a substance that he dubbed “Flavone-X.” Duchaine claimed that Flavone-X, which was a natural flavone existing in plants, could boost testosterone an average of 20 to 30 percent. It turned out that Flavone-X was actually an esoteric substance called chrysin. A study had been published that compared the activity of a number of natural flavonoids and flavones to the drug Cydadren in their ability to inhibit the enzyme aromatase, which works by converting androgens, including testosterone, into estrogen. Blocking the effect of aromatase would not only lower estrogen levels but also boost testosterone. Elevated estrogen in the blood sends an inhibitory message to the pituitary gland in the brain, which responds by lowering the output of gonadatropins, hormones that stimulate the body’s testosterone production.\u003c\/p\u003e\n\u003cp\u003eAs most of you know this was one of Duchain's only \"misses\" when it came to finding innovative compounds....\u003cstrong\u003ebut was it? \u003c\/strong\u003eIn Human tissue experiments with this monoflavone demonstrated the ability to limit aromatase activity. Aromatase is an enzyme that is found in various tissues within the body and is responsible for the conversion of androstenedione and testosterone into estrogen. This conversion is utilized by the body to keep Testosterone: Estrogen ratios in balance. When athletes are in quest of increasing lean body mass, maximizing serum testosterone levels is of paramount concern. In the study that compared natural flavonoids to cytadren, chrysin came out on top, actually showing effects against aromatase that were superior to the potent drug. The problem was, it was an in vitro, or isolated-cell, study. The question then became, How well does chrysin work in the body? Humans had unknowingly been consuming chrysin, since it’s found naturally in honey, propolis and in the passion flower plant, but initial animal-based and later human studies proved to be disappointing.\u003c\/p\u003e\n\u003cp\u003eIt’s clear that chrysin seemed to work better in a test tube than it does in the human body. The reason for that was due to the difficulty in absorbing chrysin into the body. That was when the supplement industry gave up on Chrysin — but not APS researchers who were big fans of Duchaine's and saw him develop a novel delivery system with DMSO for Finaplex pellets, which was definitely ahead of his time in delivery systems.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTHE KEY TO CHRYSIN'S SUCCESS OR FAILURE IS ALL IN THE DELIVERY! \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhether a man's sex hormones are out of whack because of father time, or because of a self-inflicted blast of anabolic steroids, maintaining elevated levels of testosterone, while minimizing the production of estradiol and DHT, is one of the most important steps men can take to remain healthy, improve performance, and keep hard-earned muscle intact. Arimigen will help to restore healthy testosterone to estradiol ratios, or can be used by a bodybuilder looking for an estrogen-squashing, testosterone-unleashing, muscle-building supplement for the anabolic support required to achieve a hard, lean physique!\u003c\/p\u003e\n\u003cp\u003eChrysin is a well studied nutraceutical and its benefits greatly depend on its solubilization (bioaccessibility) and subsequent absorption through cell lining so that it can reach lymphatic systemic\/general circulation. Unfortunately, Chrysin has low water solubility and undergoes rapid metabolism on oral delivery. Lipids have shown to affect the absorption of poorly soluble nutraceuticals such as Chrysin by enhancing solubilization in the intestinal milieu through alterations to the composition and character of the colloidal environment – e.g. vesicles, mixed micelles when delivered orally. The presence of lipids in the GI tract stimulates the contraction of gall bladder. This leads to the release of biliary and pancreatic secretions such as phospholipids (PL), cholesterol (Ch), pancreatic lipase and other enzymes. PL and Ch form intestinal mixed micelles which increase the solubilization of lipophilic bioactives. In addition, the digestion of lipids leads to the formation of free fatty acids and monoglycerides, these along with biliary compounds\u003c\/p\u003e\n\u003cp\u003eand emulsifiers or co-solvents used in formulation, aid in the formation of mixed micelles, micelles, liposomes and vesicles which further prevent the precipitation of lipophilic bioactives and increase their solubilization. The solubilized bioactives are easily absorbed through the intestinal cell wall. Thus this mechanism directly affects the bioavailability of lipophilic bioactives by increasing its bioaccessibility.\u003c\/p\u003e\n\u003cp\u003eAPS Researchers studied three types of lipid based delivery systems were evaluated for increasing bioaccessibility of Chrysin. With over 10 types of delivery methods studies we found four types of lipid based delivery systems, namely nanoemulsions, gel-like emulsions, Cocrystallization and organogels that proved effective in increasing the bioaccessibility of Chrysin when compared to the dispersion of the compound in water. APS Researchers concluded that less than 1% of the Chrysin was absorbed unchanged in the gastrointestinal tract. This was not surprising given that Chrysin has extremely low water solubility, a major factor in drug absorption. Not only was Chrysin absorbed poorly but also it was conjugated extensively in the liver following oral administration. Our proprietary two stage delivery system was shown to increase the solubility 14-fold. We hypothesized that this improved solubility would translate into enhanced systemic absorption of Chrysin. This hypothesis was supported in our pharmacokinetic study. The outperformed Chrysin with increases in bioavailability up to nearly 10-fold!\u003c\/p\u003e\n\u003cp\u003eIn addition to these ingredients and cutting-edge science, an extremely high quality Urtica Dioica extract is also included in Arimigen™ because it has been shown to support two complementary pathways involved estrogen modulation and free testosterone enhancement — most notably for its known contribution to enhancing free testosterone levels via inhibition of the action of SHBG.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eArimigen™ is a formula that is designed to optimize and support an anabolic environment by decreasing estrogen and increasing testosterone levels. This formulation aggressively combats heightened estrogen levels often associated with heavy steroid, prohormone, and prosteroid cycles. \u003c\/span\u003e\u003cbr\u003e \u003cbr\u003e \u003cspan\u003eUltimately, Arimigen™ allows the user to get the anabolic benefits of heightened testosterone levels without the negative side-effects of estrogen (a by-product of heightened testosterone), water retention and body-fat accumulation that usually accompany heightened levels of testosterone in the body. Arimigen™ is comprised of specific compounds working synergistically at blocking testosterone from converting into estrogens. \u003c\/span\u003e\u003cbr\u003e \u003cspan\u003eArimigen™ also works by metabolizing active estrogens into inactive estrogen metabolites, blocking estrogen, and by freeing excess estrogen from the body. What's more, Arimigen™ can down regulate SHBG (Sex hormone-binding globulin) and therefore known to support increased FREE testosterone levels from within the body. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eAs a dietary supplement, take 2 tablets one or two times daily on an empty stomach. Take 8-12 hours apart. Do not exceed 4 tablets per day.\u003c\/p\u003e","published_at":"2015-06-25T16:51:00-05:00","created_at":"2015-07-28T14:32:58-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":["Add Muscle","Muscle \u0026 Strength","Testosterone Support"],"price":5995,"price_min":5995,"price_max":5995,"available":false,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":5113776769,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APARI60","requires_shipping":true,"taxable":false,"featured_image":null,"available":false,"name":"Arimigen™","public_title":null,"options":["Default Title"],"price":5995,"weight":227,"compare_at_price":null,"inventory_quantity":0,"inventory_management":"shopify","inventory_policy":"deny","barcode":"649241899976"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/ARIMIGEN.jpg?v=1512488271"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/ARIMIGEN.jpg?v=1512488271","options":["Title"],"content":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eArimigen\u003c\/strong\u003e\u003cstrong\u003e™\u003c\/strong\u003e \u003cstrong\u003eSupports Decrease of Estrogen \u0026amp; Increase of Testosterone Levels!* \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eArimigen™ — APS Nutrition's novel Aromatase Inhibitor is a new ground breaking formula designed to optimize an anabolic environment by decreasing estrogen and increasing testosterone levels. Arimigen™ is a multi-pathway formulation that minimizes or eliminates the undesirable effects associated with an estrogen dominant environment. Arimigen™ maintains the correct testosterone to estrogen ratios that yield the benefits associated with normal estrogen levels. Arimigen™ acts as an anti-aromatase agent and is thus a powerful elevator of total testosterone and maximum liberator of free testosterone. This one-of-a- kind formulation is exclusively manufactured by APS and aggressively combats heightened estrogen levels that can come with elevated testosterone. *\u003c\/p\u003e\n\u003cbr\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/arimigen_large.png?10323656229900534673\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eArimigen™ allows the user to get the anabolic benefits of increased testosterone levels without the negative side-effects of estrogen (the downside of elevated testosterone), water retention and unattractive body-weight accumulation that usually accompany elevated levels of testosterone in the body. Arimigen™ is appropriately used when using substantial amounts of aromatizing hormones or prohormones. Arimigen™ also works by metabolizing active estrogens into inactive estrogen metabolites, blocking estrogen at the actual estrogen receptor site in male breast tissue, and by freeing excess estrogen from the body. Arimigen™ also will help to down regulate SHBG (Sex hormone-binding globulin) and therefore known to support increased FREE testosterone levels.\u003c\/p\u003e\n\u003cp\u003eThe Arimigen™ proprietary formula was developed by combining naturally occurring aromatase inhibitors and inhibitors of the action of SHBG. The dietary supplement Arimigen™ is a multi-pathway agent that exerts its influence by blocking various stages in the aromatase process and by inhibiting SHBG's action; an activity not clearly addressed by any of the aromatase inhibiting or anti-estrogen products. Further, it appears that use of Arimigen™ may result in long-term blocking of selective anabolic estrogen receptors and\/or inhibition of selective estrogen signaling. This activity has not been addressed by any known dietary supplements or pharmacological agents. \u003c\/p\u003e\n\u003cp\u003eArimigen™ acts as an Elevator of total testosterone and liberator of free testosterone. As a powerful aromatase inhibitor, Arimigen™ also possesses notable testosterone stimulating properties. The aromatase inhibiting action reduces the signal that estrogen sends to the brain to suppress endogenous testosterone production (estrogen is a main feedback signal to control the release of testosterone, thus increasing the testicular output of testosterone). Arimigen™ thus assists in resetting the body's level of its own natural testosterone production by regulating the activity of the hypothalamic-pituitary-testicular axis (HPTA), which constantly adjusts the body's production of testosterone to maintain target blood levels. Continued use of Arimigen™ results in not only a significant reduction in the production of estrogen, but also a corresponding substantial increase in endogenous testosterone. Only Arimigen™ addresses all possible channels to estrogen maintenance and free testosterone elevation, which means optimal hormonal levels for muscle building and dry, hard physique.\u003c\/p\u003e\n\u003cp\u003eArimigen™ is based primarily on the testosterone, LH, FSH, libido and lean mass extreme stimulatory compound referred to as ‘Akarkara’ in Anacyclus pyrethrum, the information has been widely recognized in the Ayurvedic system of Indian medicine for over 2 centuries. Not a “discovery” for us, more of an advanced understanding was accomplished with patience on our part. Our testing, research and patience paid off by allowing us to release of Arimigen™ with a multi-independent study validated extract that \u003cstrong\u003eoutperformed the other common extract on the market by over 71% for mass gain!\u003c\/strong\u003e Arimigen™ also contains a \"supporting cast\" of ingredients that have individually been shown to support inhibition of excessive estrogen formation that make Arimigen™ truly revolutionary.\u003c\/p\u003e\n\u003cp\u003eThe first of these ingredients is an extract derived from the leaves of Brassaiopsis glomerulata (standardized to 6ß-hydroxystimasta-4- en-3-one and N-benzoyl-L-phenylalanine methyl ester). APS’s unique extraction process of this plant results an extract that produce 13 isolated estrogen-modulating compounds.\u003c\/p\u003e\n\u003cp\u003eAs mentioned above, the attractive effect of Brassaiopsis glomerulata extract is due to its aromatase inhibition property. Aromatase is the enzyme responsible for catalyzing the last steps of biosynthesis of estrogens (estrone and estradiol) from androgens (androstenedione and testosterone). Inhibition of aromatase has been shown to reduce estrogen production throughout the body to nearly undetectable levels.\u003c\/p\u003e\n\u003cp\u003e\u003cimg width=\"411\" height=\"83\" style=\"float: right;\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/ARIMIGEN_09c86494-ddcc-4f62-bb5f-d0f34123edb8.png?4199550805568428710\"\u003eBodybuilders that take anabolic ingredients often use aromatase inhibitors in order to minimize or avoid estrogenic effects. Aromatase inhibitors can prevent elevated levels of testosterone from being converted to excess estrogen and have also been shown to reverse age-related decline in testosterone.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eArimigen™ also contains a 98% highly purified version of Chrysin (5,7-dihydroxyflavone) which is the name of a monoflavone extracted from a plant called \"Passiflora caerulea\". Flavones, a group of compounds found in many different plants, are known to have numerous therapeutic effects. Of all the unique biological activities, Chrysin has generated the most interest as an aromatase inhibitor, which has also been shown to control estrogen through modulation of estrogen metabolism. In the May ’96 issue of \u003cem\u003eMuscle Media 2000\u003c\/em\u003e, the late Dan Duchaine, known as the “steroid guru,” discussed a substance that he dubbed “Flavone-X.” Duchaine claimed that Flavone-X, which was a natural flavone existing in plants, could boost testosterone an average of 20 to 30 percent. It turned out that Flavone-X was actually an esoteric substance called chrysin. A study had been published that compared the activity of a number of natural flavonoids and flavones to the drug Cydadren in their ability to inhibit the enzyme aromatase, which works by converting androgens, including testosterone, into estrogen. Blocking the effect of aromatase would not only lower estrogen levels but also boost testosterone. Elevated estrogen in the blood sends an inhibitory message to the pituitary gland in the brain, which responds by lowering the output of gonadatropins, hormones that stimulate the body’s testosterone production.\u003c\/p\u003e\n\u003cp\u003eAs most of you know this was one of Duchain's only \"misses\" when it came to finding innovative compounds....\u003cstrong\u003ebut was it? \u003c\/strong\u003eIn Human tissue experiments with this monoflavone demonstrated the ability to limit aromatase activity. Aromatase is an enzyme that is found in various tissues within the body and is responsible for the conversion of androstenedione and testosterone into estrogen. This conversion is utilized by the body to keep Testosterone: Estrogen ratios in balance. When athletes are in quest of increasing lean body mass, maximizing serum testosterone levels is of paramount concern. In the study that compared natural flavonoids to cytadren, chrysin came out on top, actually showing effects against aromatase that were superior to the potent drug. The problem was, it was an in vitro, or isolated-cell, study. The question then became, How well does chrysin work in the body? Humans had unknowingly been consuming chrysin, since it’s found naturally in honey, propolis and in the passion flower plant, but initial animal-based and later human studies proved to be disappointing.\u003c\/p\u003e\n\u003cp\u003eIt’s clear that chrysin seemed to work better in a test tube than it does in the human body. The reason for that was due to the difficulty in absorbing chrysin into the body. That was when the supplement industry gave up on Chrysin — but not APS researchers who were big fans of Duchaine's and saw him develop a novel delivery system with DMSO for Finaplex pellets, which was definitely ahead of his time in delivery systems.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTHE KEY TO CHRYSIN'S SUCCESS OR FAILURE IS ALL IN THE DELIVERY! \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhether a man's sex hormones are out of whack because of father time, or because of a self-inflicted blast of anabolic steroids, maintaining elevated levels of testosterone, while minimizing the production of estradiol and DHT, is one of the most important steps men can take to remain healthy, improve performance, and keep hard-earned muscle intact. Arimigen will help to restore healthy testosterone to estradiol ratios, or can be used by a bodybuilder looking for an estrogen-squashing, testosterone-unleashing, muscle-building supplement for the anabolic support required to achieve a hard, lean physique!\u003c\/p\u003e\n\u003cp\u003eChrysin is a well studied nutraceutical and its benefits greatly depend on its solubilization (bioaccessibility) and subsequent absorption through cell lining so that it can reach lymphatic systemic\/general circulation. Unfortunately, Chrysin has low water solubility and undergoes rapid metabolism on oral delivery. Lipids have shown to affect the absorption of poorly soluble nutraceuticals such as Chrysin by enhancing solubilization in the intestinal milieu through alterations to the composition and character of the colloidal environment – e.g. vesicles, mixed micelles when delivered orally. The presence of lipids in the GI tract stimulates the contraction of gall bladder. This leads to the release of biliary and pancreatic secretions such as phospholipids (PL), cholesterol (Ch), pancreatic lipase and other enzymes. PL and Ch form intestinal mixed micelles which increase the solubilization of lipophilic bioactives. In addition, the digestion of lipids leads to the formation of free fatty acids and monoglycerides, these along with biliary compounds\u003c\/p\u003e\n\u003cp\u003eand emulsifiers or co-solvents used in formulation, aid in the formation of mixed micelles, micelles, liposomes and vesicles which further prevent the precipitation of lipophilic bioactives and increase their solubilization. The solubilized bioactives are easily absorbed through the intestinal cell wall. Thus this mechanism directly affects the bioavailability of lipophilic bioactives by increasing its bioaccessibility.\u003c\/p\u003e\n\u003cp\u003eAPS Researchers studied three types of lipid based delivery systems were evaluated for increasing bioaccessibility of Chrysin. With over 10 types of delivery methods studies we found four types of lipid based delivery systems, namely nanoemulsions, gel-like emulsions, Cocrystallization and organogels that proved effective in increasing the bioaccessibility of Chrysin when compared to the dispersion of the compound in water. APS Researchers concluded that less than 1% of the Chrysin was absorbed unchanged in the gastrointestinal tract. This was not surprising given that Chrysin has extremely low water solubility, a major factor in drug absorption. Not only was Chrysin absorbed poorly but also it was conjugated extensively in the liver following oral administration. Our proprietary two stage delivery system was shown to increase the solubility 14-fold. We hypothesized that this improved solubility would translate into enhanced systemic absorption of Chrysin. This hypothesis was supported in our pharmacokinetic study. The outperformed Chrysin with increases in bioavailability up to nearly 10-fold!\u003c\/p\u003e\n\u003cp\u003eIn addition to these ingredients and cutting-edge science, an extremely high quality Urtica Dioica extract is also included in Arimigen™ because it has been shown to support two complementary pathways involved estrogen modulation and free testosterone enhancement — most notably for its known contribution to enhancing free testosterone levels via inhibition of the action of SHBG.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eArimigen™ is a formula that is designed to optimize and support an anabolic environment by decreasing estrogen and increasing testosterone levels. This formulation aggressively combats heightened estrogen levels often associated with heavy steroid, prohormone, and prosteroid cycles. \u003c\/span\u003e\u003cbr\u003e \u003cbr\u003e \u003cspan\u003eUltimately, Arimigen™ allows the user to get the anabolic benefits of heightened testosterone levels without the negative side-effects of estrogen (a by-product of heightened testosterone), water retention and body-fat accumulation that usually accompany heightened levels of testosterone in the body. Arimigen™ is comprised of specific compounds working synergistically at blocking testosterone from converting into estrogens. \u003c\/span\u003e\u003cbr\u003e \u003cspan\u003eArimigen™ also works by metabolizing active estrogens into inactive estrogen metabolites, blocking estrogen, and by freeing excess estrogen from the body. What's more, Arimigen™ can down regulate SHBG (Sex hormone-binding globulin) and therefore known to support increased FREE testosterone levels from within the body. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eAs a dietary supplement, take 2 tablets one or two times daily on an empty stomach. Take 8-12 hours apart. Do not exceed 4 tablets per day.\u003c\/p\u003e"} Muscle Building Supplement Beta Alanine DESCRIPTION BETA ALANINE - Boosts both Anaerobic And Aerobic Muscular Endurance! As an anabolic fuel BETA ALANINE helps provide the nutritional stimulus to increase anaerobic... DESCRIPTION BETA ALANINE - Boosts both Anaerobic And Aerobic Muscular Endurance! As an anabolic fuel... SKU: APBET500 Availability: In Stock $ 49.95 Add to cart Default Title Quick View {"id":426560601,"title":"Beta Alanine","handle":"beta-alanine","description":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eBETA ALANINE - Boosts both Anaerobic And Aerobic Muscular Endurance!\u003c\/h3\u003e\n\u003cp\u003eAs an anabolic fuel BETA ALANINE helps provide the nutritional stimulus to increase anaerobic and aerobic endurance and delays in muscular fatigue, allowing you to push through every workout by providing the fuel to accelerate maximal workout power.\u003c\/p\u003e\n\u003cp\u003eBeta-Alanine supports increased performance and lean mass gains by:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIncreasing muscular endurance for more productive workouts.\u003c\/li\u003e\n\u003cli\u003eIncreasing exercise capacity so you can train harder \u0026amp; longer.\u003c\/li\u003e\n\u003cli\u003eImproving muscular strength \u0026amp; power output.\u003c\/li\u003e\n\u003cli\u003eIncreasing intracellular carnosine levels delaying muscle fatigue and metabolic acidosis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/Beta-Alanine_large.png?17346956156275011405\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/CarnoSyn-disclaimer_large.jpg?v=1477063308\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eBETA ALANINE is a non-essential amino acid that is used by muscle cells to synthesize carnosine. Carnosine is a dipeptide (BETA ALANINE plus Histidine) that functions as a buffer for hydrogen ions (acid) produced during strenuous exercise, thus helping to maintain optimum muscular pH levels. APS uses CarnoSyn, a patented form of BETA ALANINE that has been clinically researched and gives nutritional support for muscles to work harder and longer during intense exercise. When BETA ALANINE enters the muscle cell, it becomes what we call the “rate limiting substrate” to carnosine synthesis. By rate limiting, we mean that without BETA ALANINE, Carnosine does not get produced.\u003c\/p\u003e\n\u003cp\u003eCarnosine was discovered in Russia in 1900, but it wasn’t until over 50 years later that the first research on carnosine and it’s effects on muscle buffering were published. Recently (2003) researchers have been studying BETA ALANINE examining its effects on exercise performance and lean muscle mass. Carnosine on the other hand helps stabilize muscular pH by soaking up hydrogen ions (H+) that are released at an accelerated rate during exercise. Our bodies work to keep our pH in balance by utilizing various buffering systems. Buffers largely work by soaking up H+ to maintain optimal pH balance, which we need to function most effectively.\u003c\/p\u003e\n\u003cp\u003eIf you want your muscles to remain strong and maintain powerful contractions, they need to be in an optimal pH range. If they don’t and the pH drops below the optimal level, you have significantly less strength and you will fatigue more quickly. You know this is happening when you feel that familiar burn in your muscles or even when you’re lifting heavy and reach muscular failure. Muscle pH drops and it’s largely a result of an increase in hydrogen ions (H+) which build up when you break down the high energy compound ATP during exercise. Wouldn’t it be nice to knock out a few more reps? If you had more carnosine in your muscles, you would. Without it, your energy and endurance decline rapidly and your strength suffers. The breakdown of ATP and the subsequent rise in H+ concentrations occurs in all of our energy systems but is most prevalent in an energy system called glycolysis which also produces lactic acid. Lactic acid releases H+ ions, contributing further to the pool of H+ that’s filling your muscles from the breakdown of ATP. With the presence of Hydrogen ions, pH drops fast as does muscular performance. High muscle carnosine levels help promote a dramatic increase in muscular strength, size, and endurance. Harness the power of BETA ALANINE and help maximize your workout performance and intensity!\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePharmaceutical grade ultra-pure for maximum bio-availability.\u003c\/li\u003e\n\u003cli\u003ePure amino acid with no fillers or additives.\u003c\/li\u003e\n\u003cli\u003eHPLC verified.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBeta Alanine is a lactic acid buffer that increases training capacity giving you the ability to train harder and longer. Weight training and athletic activities cause your body to produce lactic acid. This causes muscle pH to drop and become more acidic due to the large amount of hydrogen ions produced. As muscle pH drops, your muscle’s ability to perform at its peak level decreases. Beta Alanine works by increasing muscle carnosine levels, which in turn, works as a muscle buffer by soaking up these extra hydrogen ions. In scientific studies, beta Alanine has been shown to increase strength, power output, endurance, exercise capacity, muscle mass, and delay the onset of neuromuscular fatigue. Beta Alanine is perfect for anyone who practices a sport where strength, power and endurance are needed.\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eTo optimize strength and endurance and maximize muscle carnosine levels, consume 1 serving before and after your workout. On off days, consume one serving in the morning and again in the afternoon.\u003c\/p\u003e","published_at":"2015-03-14T17:17:00-05:00","created_at":"2015-03-14T17:24:18-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":["Add Muscle"],"price":4995,"price_min":4995,"price_max":4995,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":1122243553,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APBET500","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"Beta Alanine","public_title":null,"options":["Default Title"],"price":4995,"weight":635,"compare_at_price":null,"inventory_quantity":-9,"inventory_management":null,"inventory_policy":"deny","barcode":"649241895428"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/APS_500g_BetaAlanine.jpg?v=1516821097"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/APS_500g_BetaAlanine.jpg?v=1516821097","options":["Title"],"content":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eBETA ALANINE - Boosts both Anaerobic And Aerobic Muscular Endurance!\u003c\/h3\u003e\n\u003cp\u003eAs an anabolic fuel BETA ALANINE helps provide the nutritional stimulus to increase anaerobic and aerobic endurance and delays in muscular fatigue, allowing you to push through every workout by providing the fuel to accelerate maximal workout power.\u003c\/p\u003e\n\u003cp\u003eBeta-Alanine supports increased performance and lean mass gains by:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIncreasing muscular endurance for more productive workouts.\u003c\/li\u003e\n\u003cli\u003eIncreasing exercise capacity so you can train harder \u0026amp; longer.\u003c\/li\u003e\n\u003cli\u003eImproving muscular strength \u0026amp; power output.\u003c\/li\u003e\n\u003cli\u003eIncreasing intracellular carnosine levels delaying muscle fatigue and metabolic acidosis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/Beta-Alanine_large.png?17346956156275011405\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/CarnoSyn-disclaimer_large.jpg?v=1477063308\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eBETA ALANINE is a non-essential amino acid that is used by muscle cells to synthesize carnosine. Carnosine is a dipeptide (BETA ALANINE plus Histidine) that functions as a buffer for hydrogen ions (acid) produced during strenuous exercise, thus helping to maintain optimum muscular pH levels. APS uses CarnoSyn, a patented form of BETA ALANINE that has been clinically researched and gives nutritional support for muscles to work harder and longer during intense exercise. When BETA ALANINE enters the muscle cell, it becomes what we call the “rate limiting substrate” to carnosine synthesis. By rate limiting, we mean that without BETA ALANINE, Carnosine does not get produced.\u003c\/p\u003e\n\u003cp\u003eCarnosine was discovered in Russia in 1900, but it wasn’t until over 50 years later that the first research on carnosine and it’s effects on muscle buffering were published. Recently (2003) researchers have been studying BETA ALANINE examining its effects on exercise performance and lean muscle mass. Carnosine on the other hand helps stabilize muscular pH by soaking up hydrogen ions (H+) that are released at an accelerated rate during exercise. Our bodies work to keep our pH in balance by utilizing various buffering systems. Buffers largely work by soaking up H+ to maintain optimal pH balance, which we need to function most effectively.\u003c\/p\u003e\n\u003cp\u003eIf you want your muscles to remain strong and maintain powerful contractions, they need to be in an optimal pH range. If they don’t and the pH drops below the optimal level, you have significantly less strength and you will fatigue more quickly. You know this is happening when you feel that familiar burn in your muscles or even when you’re lifting heavy and reach muscular failure. Muscle pH drops and it’s largely a result of an increase in hydrogen ions (H+) which build up when you break down the high energy compound ATP during exercise. Wouldn’t it be nice to knock out a few more reps? If you had more carnosine in your muscles, you would. Without it, your energy and endurance decline rapidly and your strength suffers. The breakdown of ATP and the subsequent rise in H+ concentrations occurs in all of our energy systems but is most prevalent in an energy system called glycolysis which also produces lactic acid. Lactic acid releases H+ ions, contributing further to the pool of H+ that’s filling your muscles from the breakdown of ATP. With the presence of Hydrogen ions, pH drops fast as does muscular performance. High muscle carnosine levels help promote a dramatic increase in muscular strength, size, and endurance. Harness the power of BETA ALANINE and help maximize your workout performance and intensity!\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePharmaceutical grade ultra-pure for maximum bio-availability.\u003c\/li\u003e\n\u003cli\u003ePure amino acid with no fillers or additives.\u003c\/li\u003e\n\u003cli\u003eHPLC verified.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBeta Alanine is a lactic acid buffer that increases training capacity giving you the ability to train harder and longer. Weight training and athletic activities cause your body to produce lactic acid. This causes muscle pH to drop and become more acidic due to the large amount of hydrogen ions produced. As muscle pH drops, your muscle’s ability to perform at its peak level decreases. Beta Alanine works by increasing muscle carnosine levels, which in turn, works as a muscle buffer by soaking up these extra hydrogen ions. In scientific studies, beta Alanine has been shown to increase strength, power output, endurance, exercise capacity, muscle mass, and delay the onset of neuromuscular fatigue. Beta Alanine is perfect for anyone who practices a sport where strength, power and endurance are needed.\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eTo optimize strength and endurance and maximize muscle carnosine levels, consume 1 serving before and after your workout. On off days, consume one serving in the morning and again in the afternoon.\u003c\/p\u003e"} Muscle Building Supplement Creatine Monohydrate DESCRIPTION CREATINE MONOHYDRATE- HPLC Verified Pure 100% Potency! Short term supplementation of creatine has been shown to significantly increase muscular performance. It is felt that... DESCRIPTION CREATINE MONOHYDRATE- HPLC Verified Pure 100% Potency! Short term supplementation of creatine has been... SKU: APCREMONO500 Availability: In Stock $ 22.95 Add to cart Default Title Quick View {"id":426570957,"title":"Creatine Monohydrate","handle":"creatine-monohydrate","description":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eCREATINE MONOHYDRATE- HPLC Verified Pure 100% Potency!\u003c\/h3\u003e\n\u003cp\u003eShort term supplementation of creatine has been shown to significantly increase muscular performance. It is felt that it may help athletes work out at a higher intensity during resistance exercise. A resulting greater training stimulus over time may result in enhanced physiologic adaptations. In the body, creatine helps to regenerate ADP (spent energy) back into ATP for increased energy output involving short, intense bursts of energy.\u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/creatine_c7a124d5-8a71-4e99-bc30-878054fa1fe9_large.png?16431472852023061670\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eCreatine is a natural substance that is synthesized in the body from three amino acids, arginine, glycine and methionine. It’s also found naturally in certain foods. Our supplier is the largest Creatine Monohydrate manufacturer in the world and holds the USA patent (#US6,326,513) for Creatine Monohydrate production. This patented manufacturing processes eliminates unwanted by-products often found in lesser quality creatine. Inferior raw materials and manufacturing processes that are not continuously monitored or adapted to the product, result in impurities such as creatinine, dicyandiamide, dihydrotriazine and if so thiourea.\u003c\/p\u003e\n\u003cp\u003eCreatine is a non-essential amino acid that is an important source of chemical energy for muscle contraction. Once creatine reaches the muscles, it’s converted into Phosphocreatine (creatine phosphate), and ultimately becomes the body’s primary energy source; adenosine triphosphate. In your skeletal muscles, where you generate the energy for movement, creatine participates in the complex muscle contraction process to maximize muscle energy. Adenosine Triphosphate, abbreviated to ATP, is a key fuel for muscle contraction, the repetition exercises you perform when bodybuilding. The more ATP you make available to your muscles the more energy created to power bodybuilding and boost performance in aerobic energy demanding sports, like sprinting, rowing, bodybuilding. Normal levels of ATP allow you only a few seconds of high intensity energy.\u003c\/p\u003e\n\u003cp\u003eAlthough creatine’s role in the energy production process is its most notable trait, there is evidence that creatine can stimulate muscle growth. It does this a couple of different ways. By allowing you to perform more work as a result of additional energy, increased protein synthesis is stimulated. Secondly, when an abundance of creatine phosphate is stored in the muscle, the muscle will hold more water in its cells and become what is known as “volumized” or “super-hydrated.” The more volumized a muscle is, the more it will promote the synthesis of protein as well as deter the breakdown of protein. Volumizing the muscle will also create an environment where an increased level of Glycogen Synthesis will take place. Increased protein synthesis along with training will lead to muscle growth. There is also scientific evidence that shows supplementation with creatine causes muscle tears to repair themselves quicker. The conversion of ADP to ATP takes place inside the mitochondria. These are tiny “power plants” that convert energy. The mitochondria are where cellular respiration takes place, which is the process that generates the fuel that our cells use as energy.\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eAs a dietary supplement, take 1 scoop daily or as directed by a physician. For loading: take 1 serving (5 grams) 4 times per day (total of 20 grams) for 5 days with 12-16 oz of water or non-acidic juice. For maintenance: take 1 serving (5 grams) daily with 12-16 oz of water or non-acidic juice.\u003c\/p\u003e","published_at":"2015-03-14T18:07:00-05:00","created_at":"2015-03-14T18:07:28-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":["Add Muscle"],"price":2295,"price_min":2295,"price_max":2295,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":1122305685,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APCREMONO500","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"Creatine Monohydrate","public_title":null,"options":["Default Title"],"price":2295,"weight":635,"compare_at_price":null,"inventory_quantity":-9,"inventory_management":null,"inventory_policy":"deny","barcode":"649241897701"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/APS_500g_CreatineMono.jpg?v=1516821114"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/APS_500g_CreatineMono.jpg?v=1516821114","options":["Title"],"content":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eCREATINE MONOHYDRATE- HPLC Verified Pure 100% Potency!\u003c\/h3\u003e\n\u003cp\u003eShort term supplementation of creatine has been shown to significantly increase muscular performance. It is felt that it may help athletes work out at a higher intensity during resistance exercise. A resulting greater training stimulus over time may result in enhanced physiologic adaptations. In the body, creatine helps to regenerate ADP (spent energy) back into ATP for increased energy output involving short, intense bursts of energy.\u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/creatine_c7a124d5-8a71-4e99-bc30-878054fa1fe9_large.png?16431472852023061670\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eCreatine is a natural substance that is synthesized in the body from three amino acids, arginine, glycine and methionine. It’s also found naturally in certain foods. Our supplier is the largest Creatine Monohydrate manufacturer in the world and holds the USA patent (#US6,326,513) for Creatine Monohydrate production. This patented manufacturing processes eliminates unwanted by-products often found in lesser quality creatine. Inferior raw materials and manufacturing processes that are not continuously monitored or adapted to the product, result in impurities such as creatinine, dicyandiamide, dihydrotriazine and if so thiourea.\u003c\/p\u003e\n\u003cp\u003eCreatine is a non-essential amino acid that is an important source of chemical energy for muscle contraction. Once creatine reaches the muscles, it’s converted into Phosphocreatine (creatine phosphate), and ultimately becomes the body’s primary energy source; adenosine triphosphate. In your skeletal muscles, where you generate the energy for movement, creatine participates in the complex muscle contraction process to maximize muscle energy. Adenosine Triphosphate, abbreviated to ATP, is a key fuel for muscle contraction, the repetition exercises you perform when bodybuilding. The more ATP you make available to your muscles the more energy created to power bodybuilding and boost performance in aerobic energy demanding sports, like sprinting, rowing, bodybuilding. Normal levels of ATP allow you only a few seconds of high intensity energy.\u003c\/p\u003e\n\u003cp\u003eAlthough creatine’s role in the energy production process is its most notable trait, there is evidence that creatine can stimulate muscle growth. It does this a couple of different ways. By allowing you to perform more work as a result of additional energy, increased protein synthesis is stimulated. Secondly, when an abundance of creatine phosphate is stored in the muscle, the muscle will hold more water in its cells and become what is known as “volumized” or “super-hydrated.” The more volumized a muscle is, the more it will promote the synthesis of protein as well as deter the breakdown of protein. Volumizing the muscle will also create an environment where an increased level of Glycogen Synthesis will take place. Increased protein synthesis along with training will lead to muscle growth. There is also scientific evidence that shows supplementation with creatine causes muscle tears to repair themselves quicker. The conversion of ADP to ATP takes place inside the mitochondria. These are tiny “power plants” that convert energy. The mitochondria are where cellular respiration takes place, which is the process that generates the fuel that our cells use as energy.\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eAs a dietary supplement, take 1 scoop daily or as directed by a physician. For loading: take 1 serving (5 grams) 4 times per day (total of 20 grams) for 5 days with 12-16 oz of water or non-acidic juice. For maintenance: take 1 serving (5 grams) daily with 12-16 oz of water or non-acidic juice.\u003c\/p\u003e"} Muscle Building Supplement L-Glutamine DESCRIPTION APS L-GLUTAMINE (Ajinomoto AjiPure 100% pure Pharmaceutical Grade) APS L-GLUTAMINE is designed for anyone who trains with weights, including bodybuilders and strength athletes, to... DESCRIPTION APS L-GLUTAMINE (Ajinomoto AjiPure 100% pure Pharmaceutical Grade) APS L-GLUTAMINE is designed for anyone... SKU: APLGL500 Availability: Temporarily Out of Stock Coming Soon Add to cart Quick View {"id":426587781,"title":"L-Glutamine","handle":"l-glutamine","description":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eAPS L-GLUTAMINE (Ajinomoto AjiPure 100% pure Pharmaceutical Grade)\u003c\/h3\u003e\n\u003cp\u003eAPS L-GLUTAMINE is designed for anyone who trains with weights, including bodybuilders and strength athletes, to accelerate building muscle and strength by increasing protein synthesis and speeding up recovery times after workouts!\u003c\/p\u003e\n\u003cp\u003eL-Glutamine plays a crucial role in cell volumizing and has powerful muscle building effects, promoting protein synthesis while inhibiting protein breakdown. APS L-Glutamine is HPLC Verified Pure 100% Pharmaceutical Grade and has been shown to help aid in the following:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003eIncreases protein synthesis \u0026amp; growth hormone secretion.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003ePromotes nitrogen retention \u0026amp; muscle cell volumizing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eSpeeds recovery after workouts.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eOptimize glucose \u0026amp; insulin function.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eHelps prevent muscle breakdown.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eImproves immune system function\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/L-Glutamine_grande.png?9129208817597866114\"\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eAPS Nutritions L-GLUTAMINE is referred to as a “conditionally essential amino acid” meaning in catabolic states brought on by exercise induced muscular stress, L-GLUTAMINE becomes essential (requiring intake from food or supplements) because the body can’t keep up with production. L-GLUTAMINE is the most abundant amino acid in the human body and is involved in many metabolic processes including the synthesis and protection of muscle tissue and the production of glycogen. First and foremost L-GLUTAMINE is a fuel source for enterocytes (intestinal cells), nutritionally supporting the integrity of the intestinal lining. L-GLUTAMINE supplementation may help support healthy muscle tissue repair and recovery needs.\u003c\/p\u003e\n\u003cp\u003eWith over 350 patents, Ajinomoto is truly a world innovator when it comes to amino acids. Produced through microbiological fermentation using natural raw ingredients of non-animal origin Ajipure L-GLUTAMINE is USP\/FCC grade and is the only L-GLUTAMINE in the world manufactured to the most exacting pharmaceutical standards by the world’s largest amino acid manufacturer. L-GLUTAMINE is involved in maintaining a positive nitrogen balance (an anabolic state). L-GLUTAMINE plays a major role in DNA synthesis and serves as a primary transporter of nitrogen into the muscle tissues. It serves to replenish nitrogen loss due to excessive muscle training and speeds up recovery. It is so vital to the building and maintenance of muscle tissue that 60% of the human intracellular amino acid pool is L-GLUTAMINE. The very fact that muscle is the most important tissue for L-GLUTAMINE synthesis and storage, is evidence of its vital role in maintaining positive nitrogen balance and the building of these important sport support structures.\u003c\/p\u003e\n\u003cp\u003eAPS uses 100% vegetable based, naturally fermented Ajinomoto pharmaceutical L-Glutamine only! You simply cannot get any better glutamine. We ship from our own FDA registered and inspected GMP manufacturing facility direct to your door. No middlemen to mark up the price and no old or expired product like most re-sellers ship. This is the freshest and purest glutamine available – guaranteed. Glutamine is the most abundant amino acid in the body. It plays a crucial role in cell volumizing and has powerful muscle building effects, promoting protein synthesis while inhibiting protein breakdown. Loading with glutamine may even increase the secretion of growth hormone. Studies show that supplementing with as little as two grams of free-form L-Glutamine may boost your growth hormone levels by as much as 400%.\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eMix one rounded teaspoon of L-Glutamine powder with 8 oz of water or your favorite beverage, or use as directed by a physician or licensed nutritionist.\u003c\/p\u003e","published_at":"2015-03-14T18:14:00-05:00","created_at":"2015-03-14T18:14:57-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":["Add Muscle"],"price":4295,"price_min":4295,"price_max":4295,"available":false,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":1122328357,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APLGL500","requires_shipping":true,"taxable":false,"featured_image":null,"available":false,"name":"L-Glutamine","public_title":null,"options":["Default Title"],"price":4295,"weight":635,"compare_at_price":null,"inventory_quantity":0,"inventory_management":"shopify","inventory_policy":"deny","barcode":"649241899901"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/L-GLUTAMINE.jpg?v=1511213721"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/L-GLUTAMINE.jpg?v=1511213721","options":["Title"],"content":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eAPS L-GLUTAMINE (Ajinomoto AjiPure 100% pure Pharmaceutical Grade)\u003c\/h3\u003e\n\u003cp\u003eAPS L-GLUTAMINE is designed for anyone who trains with weights, including bodybuilders and strength athletes, to accelerate building muscle and strength by increasing protein synthesis and speeding up recovery times after workouts!\u003c\/p\u003e\n\u003cp\u003eL-Glutamine plays a crucial role in cell volumizing and has powerful muscle building effects, promoting protein synthesis while inhibiting protein breakdown. APS L-Glutamine is HPLC Verified Pure 100% Pharmaceutical Grade and has been shown to help aid in the following:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003eIncreases protein synthesis \u0026amp; growth hormone secretion.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003ePromotes nitrogen retention \u0026amp; muscle cell volumizing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eSpeeds recovery after workouts.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eOptimize glucose \u0026amp; insulin function.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eHelps prevent muscle breakdown.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eImproves immune system function\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/L-Glutamine_grande.png?9129208817597866114\"\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eAPS Nutritions L-GLUTAMINE is referred to as a “conditionally essential amino acid” meaning in catabolic states brought on by exercise induced muscular stress, L-GLUTAMINE becomes essential (requiring intake from food or supplements) because the body can’t keep up with production. L-GLUTAMINE is the most abundant amino acid in the human body and is involved in many metabolic processes including the synthesis and protection of muscle tissue and the production of glycogen. First and foremost L-GLUTAMINE is a fuel source for enterocytes (intestinal cells), nutritionally supporting the integrity of the intestinal lining. L-GLUTAMINE supplementation may help support healthy muscle tissue repair and recovery needs.\u003c\/p\u003e\n\u003cp\u003eWith over 350 patents, Ajinomoto is truly a world innovator when it comes to amino acids. Produced through microbiological fermentation using natural raw ingredients of non-animal origin Ajipure L-GLUTAMINE is USP\/FCC grade and is the only L-GLUTAMINE in the world manufactured to the most exacting pharmaceutical standards by the world’s largest amino acid manufacturer. L-GLUTAMINE is involved in maintaining a positive nitrogen balance (an anabolic state). L-GLUTAMINE plays a major role in DNA synthesis and serves as a primary transporter of nitrogen into the muscle tissues. It serves to replenish nitrogen loss due to excessive muscle training and speeds up recovery. It is so vital to the building and maintenance of muscle tissue that 60% of the human intracellular amino acid pool is L-GLUTAMINE. The very fact that muscle is the most important tissue for L-GLUTAMINE synthesis and storage, is evidence of its vital role in maintaining positive nitrogen balance and the building of these important sport support structures.\u003c\/p\u003e\n\u003cp\u003eAPS uses 100% vegetable based, naturally fermented Ajinomoto pharmaceutical L-Glutamine only! You simply cannot get any better glutamine. We ship from our own FDA registered and inspected GMP manufacturing facility direct to your door. No middlemen to mark up the price and no old or expired product like most re-sellers ship. This is the freshest and purest glutamine available – guaranteed. Glutamine is the most abundant amino acid in the body. It plays a crucial role in cell volumizing and has powerful muscle building effects, promoting protein synthesis while inhibiting protein breakdown. Loading with glutamine may even increase the secretion of growth hormone. Studies show that supplementing with as little as two grams of free-form L-Glutamine may boost your growth hormone levels by as much as 400%.\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eMix one rounded teaspoon of L-Glutamine powder with 8 oz of water or your favorite beverage, or use as directed by a physician or licensed nutritionist.\u003c\/p\u003e"} Muscle Building Supplement NMDA 100™ DESCRIPTION NMDA 100™ The Most Potent NMDA Testosterone Product on the Market! N-Methyl-D-Aspartic Acid (NMDA) manufactured by APS is an amino acid derivative capable of... DESCRIPTION NMDA 100™ The Most Potent NMDA Testosterone Product on the Market! N-Methyl-D-Aspartic Acid (NMDA)... SKU: APNMD60 Availability: In Stock $ 39.95 Add to cart Default Title Quick View {"id":434152049,"title":"NMDA 100™","handle":"nmda-100","description":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eNMDA 100™ The Most Potent NMDA Testosterone Product on the Market!\u003c\/h3\u003e\n\u003cp\u003eN-Methyl-D-Aspartic Acid (NMDA) manufactured by APS is an amino acid derivative capable of causing an intensely anabolic response from NMDA receptors found within our bodies. NMDA receptors are designed to accept only certain compounds to connect to them, the most potent being NMDA. When NMDA binds to an NMDA receptor our HPTA (hypothalamus-pituitary-gonadal axis) is sent into overdrive and releases a potent combination of testosterone, growth hormone, IGF-1, and IGF-2.\u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/NMDA_grande.png?3062159547201931953\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eThe Problem with NMDA is its extremely high cost to manufacture the raw material. It is about 20 times more expensive than ordinary D-Aspartic Acid. However, much less is needed to provide an ethical dosage for testosterone elevation. APS uses an ultra- pure,99.9% Pharmaceutical-Grade N-Methyl-D-Aspartic Acid for NMDA receptor activation and allosteric modulation. Activation of the NMDA receptor has shown a direct relation to increases in Luteinizing Hormone (LH) and Testosterone . Several studies have shown the relation between LH, Testosterone, NMDA activation, and NMDA administration.\u003c\/p\u003e\n\u003cp\u003e99.9% Pharmaceutical-Grade N-Methyl-D-Aspartic Acid\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eN-Methyl-D-Aspartic Acid\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNMDA has been proven to be 100x stronger than D-Aspartic Acid! Until now, the only way to activate the NMDA receptors is by using a relatively weak NMDA receptor activator, D-Aspartic Acid. D-Aspartic Acid quickly became popular when people studies revealed it could raise their testosterone by 42% in as little as 12 days. While that may sound remarkable, it has been clinically proven that while D-Aspartic Acid can activate the NMDA receptor, pure NMDA can activate the NMDA receptor more than 100x (10,000%) more effectively! So you may ask why do most supplement companies only offer the weaker version- D-Aspartic Acid (DAA). Pharmaceutical-grade NMDA costs over 20 times more than DAA but is 100 times more potent! NMDA 100 contains an incredible 100mg of pure NMDA that will be delivered straight to NMDA receptors that can then lead to unimaginable hormonal elevation! Other products claiming to contain NMDA, but very few contain 99.9% pure NMDA, and none of them deliver 100mg of this potent compound!\u003c\/p\u003e\n\u003cp\u003eBackground: Aspartic acid is one of the 20 common amino acids that are used by the body to construct proteins and is considered to be non-essential since it can be made from oxaloacetate, an intermediate of the tricarboxylic acid cycle. There are two isomers of aspartic acid, the L-isomer and the D-isomer. Only the L-isomer is used in proteins while the d-isomer is used as a neurotransmitter as D-Aspartic acid and N-methyl-D-aspartic acid. D-aspartic acid is known to stimulate the NMDA receptor.\u003c\/p\u003e\n\u003cp\u003eMore recently, D-aspartic acid has been shown to have some intriguing effects in several animal species and humans. D-aspartic acid has been shown to enhance gonadotropin, releasing hormone from the hypothalamus as well as growth hormone (GH) and luteinizing hormone (LH) release from the pituitary. Sodium D-aspartic acid has also been shown to directly increase testosterone production by the testes , DAA does this by increasing the levels of steroidogenic acute regulatory (StAR) protein. StAR plays a critical role in the production of steroid hormones in the testes and adrenals. In fact, StAR\u003c\/p\u003e\n\u003cp\u003emediates the rate-limiting step in steroid hormone production, the importation of cholesterol into the mitochondria. All steroid hormones are manufactured from cholesterol in the mitochondria and if cholesterol doesn’t get into the mitochondria, then steroid hormones, and more specifically, testosterone does not get produced. DAA increases StAR which increases cholesterol entry into the mitochondria which results in increased testosterone production.\u003c\/p\u003e\n\u003cp\u003eA study dosed 3.12 grams of sodium-DAA to adult males (27 to 37 yrs old) for 12 days resulting in a 42% increase in average testosterone levels. These may not seem like huge increases in testosterone but these are controlled, scientific results in normal healthy men . DAA is an natural amino acid that has been shown to raise testosterone levels in men, but, unfortunately, straight DAA has terrible water solubility (less than 1 gram will dissolve in 220 milliliters of water). This means that it basically sits in the digestive tract as a gritty powder and absorbs very slowly.\u003c\/p\u003e\n\u003cp\u003eAPS was the first company to introduce D-Aspartic\/NMDA technology to the market back in 2008. In fact, our groundbreaking discoveries with the product NMDA launched an entirely new category in the sports nutrition market! In fact, we found the Italian patent that invalidated Ron Kramer’s bogus patent on DAA. However, NMDA’s formula is still light years ahead of our competition and we guarantee that NMDA 100 is absolutely the most powerful and effective natural, non-steroidal testosterone increaser on the market\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdvanced Delivery System Provides Better Absorption\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAPS NMDA 100 utilizes an exclusive, proprietary and novel delivery system that combines complimentary properties of liposomes and polymeric nanoparticles i.e. nanolipobeads represent a new trend in the application of site specific target compound delivery. The problem with hormone most products on the market is that are not bio-available and do not allow you to see the amazing benefits of testosterone.\u003c\/p\u003e\n\u003cp\u003eAPS uses a unique preparation of nanolipobeads involves three important steps- (a) Preparation of PVA hydrogel nanopartices by emulsification followed by freeze thaw cyclization method (b) Surface acylation of PVA nanoparticles by treatment with polmityl chloride and (c) Preparation of nanolipobeads by formation of PE liposome on acylated PVA hydrogel nanoparticles by vesicles fusion. The Preparation of PVA hydrogel nanopartices was then optimized by various formulation and process variables variables e.g. polymer concentrations, drug concentration, emulsifier concentrations, and a number of freeze thaw cycles, stirring speed, stirring time, and sonication time to obtain nanosized PVA hydrogel nanoparticles with maximum entrapment efficiency. This scientifically-engineered delivery system allows APSNMDA 100 to be delivered into the blood stream more rapidly, where they can be better absorbed and utilized without degradation in the liver as is experienced with other products. APS holds the worldwide rights to this unique product and advanced technology protein\/peptide delivery system to this incredible Testosterone and [GnRH] Gonadotropin-Releasing Hormone Trigger.\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eConsume 1 capsule immediately before bed or upon waking. Do not consume more than 1 capsule each day. Do not exceed the recommended dosage under any circumstance.\u003c\/p\u003e","published_at":"2015-03-22T21:58:00-05:00","created_at":"2015-03-22T22:01:31-05:00","vendor":"APS Nutrition","type":"Muscle Building Supplement","tags":["Add Muscle"],"price":3995,"price_min":3995,"price_max":3995,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":1143152685,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"APNMD60","requires_shipping":true,"taxable":false,"featured_image":null,"available":true,"name":"NMDA 100™","public_title":null,"options":["Default Title"],"price":3995,"weight":91,"compare_at_price":null,"inventory_quantity":-55,"inventory_management":null,"inventory_policy":"deny","barcode":"949241874028"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/NMDA.jpg?v=1512488422"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/products\/NMDA.jpg?v=1512488422","options":["Title"],"content":"\u003ch5\u003eDESCRIPTION\u003c\/h5\u003e\n\u003ch3\u003eNMDA 100™ The Most Potent NMDA Testosterone Product on the Market!\u003c\/h3\u003e\n\u003cp\u003eN-Methyl-D-Aspartic Acid (NMDA) manufactured by APS is an amino acid derivative capable of causing an intensely anabolic response from NMDA receptors found within our bodies. NMDA receptors are designed to accept only certain compounds to connect to them, the most potent being NMDA. When NMDA binds to an NMDA receptor our HPTA (hypothalamus-pituitary-gonadal axis) is sent into overdrive and releases a potent combination of testosterone, growth hormone, IGF-1, and IGF-2.\u003c\/p\u003e\n\u003ch5\u003eSUPPLEMENT FACTS\u003c\/h5\u003e\n\u003cp\u003e\u003cimg src=\"\/\/cdn.shopify.com\/s\/files\/1\/0800\/7489\/files\/NMDA_grande.png?3062159547201931953\"\u003e\u003c\/p\u003e\n\u003ch5\u003eTHE SCIENCE\u003c\/h5\u003e\n\u003cp\u003eThe Problem with NMDA is its extremely high cost to manufacture the raw material. It is about 20 times more expensive than ordinary D-Aspartic Acid. However, much less is needed to provide an ethical dosage for testosterone elevation. APS uses an ultra- pure,99.9% Pharmaceutical-Grade N-Methyl-D-Aspartic Acid for NMDA receptor activation and allosteric modulation. Activation of the NMDA receptor has shown a direct relation to increases in Luteinizing Hormone (LH) and Testosterone . Several studies have shown the relation between LH, Testosterone, NMDA activation, and NMDA administration.\u003c\/p\u003e\n\u003cp\u003e99.9% Pharmaceutical-Grade N-Methyl-D-Aspartic Acid\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eN-Methyl-D-Aspartic Acid\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNMDA has been proven to be 100x stronger than D-Aspartic Acid! Until now, the only way to activate the NMDA receptors is by using a relatively weak NMDA receptor activator, D-Aspartic Acid. D-Aspartic Acid quickly became popular when people studies revealed it could raise their testosterone by 42% in as little as 12 days. While that may sound remarkable, it has been clinically proven that while D-Aspartic Acid can activate the NMDA receptor, pure NMDA can activate the NMDA receptor more than 100x (10,000%) more effectively! So you may ask why do most supplement companies only offer the weaker version- D-Aspartic Acid (DAA). Pharmaceutical-grade NMDA costs over 20 times more than DAA but is 100 times more potent! NMDA 100 contains an incredible 100mg of pure NMDA that will be delivered straight to NMDA receptors that can then lead to unimaginable hormonal elevation! Other products claiming to contain NMDA, but very few contain 99.9% pure NMDA, and none of them deliver 100mg of this potent compound!\u003c\/p\u003e\n\u003cp\u003eBackground: Aspartic acid is one of the 20 common amino acids that are used by the body to construct proteins and is considered to be non-essential since it can be made from oxaloacetate, an intermediate of the tricarboxylic acid cycle. There are two isomers of aspartic acid, the L-isomer and the D-isomer. Only the L-isomer is used in proteins while the d-isomer is used as a neurotransmitter as D-Aspartic acid and N-methyl-D-aspartic acid. D-aspartic acid is known to stimulate the NMDA receptor.\u003c\/p\u003e\n\u003cp\u003eMore recently, D-aspartic acid has been shown to have some intriguing effects in several animal species and humans. D-aspartic acid has been shown to enhance gonadotropin, releasing hormone from the hypothalamus as well as growth hormone (GH) and luteinizing hormone (LH) release from the pituitary. Sodium D-aspartic acid has also been shown to directly increase testosterone production by the testes , DAA does this by increasing the levels of steroidogenic acute regulatory (StAR) protein. StAR plays a critical role in the production of steroid hormones in the testes and adrenals. In fact, StAR\u003c\/p\u003e\n\u003cp\u003emediates the rate-limiting step in steroid hormone production, the importation of cholesterol into the mitochondria. All steroid hormones are manufactured from cholesterol in the mitochondria and if cholesterol doesn’t get into the mitochondria, then steroid hormones, and more specifically, testosterone does not get produced. DAA increases StAR which increases cholesterol entry into the mitochondria which results in increased testosterone production.\u003c\/p\u003e\n\u003cp\u003eA study dosed 3.12 grams of sodium-DAA to adult males (27 to 37 yrs old) for 12 days resulting in a 42% increase in average testosterone levels. These may not seem like huge increases in testosterone but these are controlled, scientific results in normal healthy men . DAA is an natural amino acid that has been shown to raise testosterone levels in men, but, unfortunately, straight DAA has terrible water solubility (less than 1 gram will dissolve in 220 milliliters of water). This means that it basically sits in the digestive tract as a gritty powder and absorbs very slowly.\u003c\/p\u003e\n\u003cp\u003eAPS was the first company to introduce D-Aspartic\/NMDA technology to the market back in 2008. In fact, our groundbreaking discoveries with the product NMDA launched an entirely new category in the sports nutrition market! In fact, we found the Italian patent that invalidated Ron Kramer’s bogus patent on DAA. However, NMDA’s formula is still light years ahead of our competition and we guarantee that NMDA 100 is absolutely the most powerful and effective natural, non-steroidal testosterone increaser on the market\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdvanced Delivery System Provides Better Absorption\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAPS NMDA 100 utilizes an exclusive, proprietary and novel delivery system that combines complimentary properties of liposomes and polymeric nanoparticles i.e. nanolipobeads represent a new trend in the application of site specific target compound delivery. The problem with hormone most products on the market is that are not bio-available and do not allow you to see the amazing benefits of testosterone.\u003c\/p\u003e\n\u003cp\u003eAPS uses a unique preparation of nanolipobeads involves three important steps- (a) Preparation of PVA hydrogel nanopartices by emulsification followed by freeze thaw cyclization method (b) Surface acylation of PVA nanoparticles by treatment with polmityl chloride and (c) Preparation of nanolipobeads by formation of PE liposome on acylated PVA hydrogel nanoparticles by vesicles fusion. The Preparation of PVA hydrogel nanopartices was then optimized by various formulation and process variables variables e.g. polymer concentrations, drug concentration, emulsifier concentrations, and a number of freeze thaw cycles, stirring speed, stirring time, and sonication time to obtain nanosized PVA hydrogel nanoparticles with maximum entrapment efficiency. This scientifically-engineered delivery system allows APSNMDA 100 to be delivered into the blood stream more rapidly, where they can be better absorbed and utilized without degradation in the liver as is experienced with other products. APS holds the worldwide rights to this unique product and advanced technology protein\/peptide delivery system to this incredible Testosterone and [GnRH] Gonadotropin-Releasing Hormone Trigger.\u003c\/p\u003e\n\u003ch5\u003eSUGGESTED USE\u003c\/h5\u003e\n\u003cp\u003eConsume 1 capsule immediately before bed or upon waking. Do not consume more than 1 capsule each day. Do not exceed the recommended dosage under any circumstance.\u003c\/p\u003e"} FeaturedProduct Isomorph™ 28 Protein $ 29.95 Already Sold: 3467 Hurry Up! Offer ends in: Questions? Call Us. 888-855-7919 Address: APS Nutrition 6015 B Unity Drive Norcross, GA 30071 Departments Protein Mass Weight Loss Muscle & Strength Testosterone Support Liver Support Find a Retailer Customer Service Search About Us Contact Us Account Login Legal Privacy Policy Refund Policy Terms of Service * Statements on this website have not been evaluated by the Food and Drug Administration. Products are not intended to diagnose, treat, cure, or prevent any disease. ©APS Nutrition. All Rights Reserved Sample Product Quantity : Add to cart