ABOUT US TECHNOLOGY PIPELINE INVESTORS CAREERS CONTACT US ABOUT US AN INTEGRIN MEDICINES LEADER Morphic Therapeutic is leading the development of a new generation of oral integrin drugs, informed by decades of world-leading expertise and a unique integrin discovery platform. Morphic believes oral drugs targeting the integrin protein family can transform the treatment paradigm for patients suffering from serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, as well as fibrosis and cancer. A PLATFORM COMPANY SUPPORTED BY MAJOR PARTNERSHIPS Morphic’s proprietary MInT drug discovery platform combines an expert understanding of integrin dynamics and analytical capabilities with foundational structural biology insights and ongoing input from the Springer laboratory, the long-term integrin research leader. Morphic has established strategic partnerships which have dramatically expanded the scope of its discovery activity, potential pipeline breadth, and growth of its internal capabilities. In 2018 Morphic announced a multi-program collaboration with AbbVie focused on fibrotic diseases, with Morphic retaining economic rights in the major area of liver fibrosis. In 2019, Morphic entered into a collaboration with Janssen covering several undisclosed programs including a mode of action and integrins not previously part of Morphic’s discovery efforts. AN AMAZING TEAM The Morphic team foster a high-performing, compassionate culture focused on scientific excellence, close collaboration with partners, authenticity and a determination to deliver an entirely new class of therapies for the many people who need them. Management Team Board of Directors Scientific Advisory Board Timothy Springer, PhD, Founder, Morphic Therapeutic Latham Family Professor at Harvard Medical School and Professor of Medicine at Children’s Hospital Boston. For more information: https://proteininnovation.org/springer-bio. Tim Springer, Ph.D. – an immunologist and biophysicist serving as Latham Family Professor at Harvard Medical School and Boston Children’s Hospital – discovered integrins and their ligands in the 1980s and since then, has worked on elucidating regulation of their biological function. His pioneering work resulted in the detailed characterization of integrin structure and robust understanding of biophysical phenomena underlying their activation. This has led to the founding of multiple biotechnology companies (LeukoSite , Scholar Rock, Morphic Therapeutic) and approved therapeutics including Amevive®, Raptiva®, Campath®, Velcade®, and Entyvio®). Morphic Therapeutics Inc., capitalizes on his 15 years of study of the molecular mode of action underlying unproductive interactions between small-molecule drugs and their integrin targets in the disease tissue. These findings make possible small molecule antagonists which reverse their activation by preventing them from occupying disease-specific signaling and conformational states. Tim is a member of Morphic Board of Directors and Scientific Advisory Board and provides strategic guidance to all research and development activities of Morphic Therapeutic. Ulrich Von Andrian, MD, PhD Mallinckrodt Professor of Immunopathology at Harvard Medical School. For more information: http://vonandrian.hms.harvard.edu/About%202014.html Ulrich H. von Andrian, M.D. received his M.D. from Ludwig-Maximilians University in Munich, Germany. He did postdoctoral work at the La Jolla Institute for Experimental Medicine and, subsequently, at Stanford University in California. He then went on to Harvard in 1994 as an Assistant Professor of Pathology at HMS, and was Senior Investigator at the CBR Institute for Biomedical Research (now called The Immune Disease Institute or IDI). He is currently the Edward Mallinckrodt Jr. Professor of Immunopathology at Harvard Medical School. Uli is a member of the European Academy of Sciences and several professional societies from which he received professional awards for outstanding research. These include the Amgen Outstanding Investigator Award (ASIP, 2004), the Henry Pickering Bowditch Award (APS, 2006), the BD Biosciences Investigator Award (AAI,2007) and the Eugene Landis Award (MCS, 2010). Albert Robichaud, PhD Chief Scientific Officer of Sage Therapeutics For more information: http://sagerx.com/ourteam.php Albert Robichaud joined SAGE as CSO in 2011, with more than 20 years of drug discovery experience focused primarily in the neuroscience arena. Most recently, he was Vice President of Chemistry and Pharmacokinetic Sciences at Lundbeck USA, where he was responsible for the drug discovery, analytical, computational and pharmacokinetics departments focused on synaptic transmission and neuroinflammation. Prior to Lundbeck, Al was Senior Director and Head of the Neuroscience Discovery Chemistry Department of Wyeth Research. During his tenure there, his group successfully delivered more than 15 drug candidates into clinical development in a broad range of neuroscience indications. Al has co-authored more than 125 manuscripts and abstracts, and is a co-inventor on 50 patents and patent applications. Heholds a B.S. in chemistry from Rensselaer Polytechnic Institute, a Ph.D. in organic chemistry from the University of California, Irvine and was an American Chemical Society postdoctoral fellow at Colorado State University. Shelia Violette, PhD Chief Scientific Officer, Admirx Dr. Violette was previously Vice President of Tissue Injury and Fibrosis Research at Biogen where she spearheaded a team of scientists conducting discovery research and developing translational approaches to advance programs into clinical development. From 2008 to 2012, Dr. Violette was Vice President of Research at Stromedix and led all research activities supporting the development of the αvβ6 antibody, STX-100. Dr. Violette has more than 20 years of industry experience advancing programs from early research to clinical development. She has provided strategic and operational leadership to multi-disciplinary teams of scientists and authored more than 90 manuscripts and patents. Dr. Violette has directed research and led therapeutic programs at several biotechnology companies including Repligen, Ariad, Stromedix and Biogen. She is currently Chief Scientific Officer, Admirx, Cambridge, MA. Dr. Violette received her Ph.D. in Pharmacology from Yale University and carried out her post-doctoral training in the Department of Biology at Yale University. Scott L. Friedman, MD Dean for Therapeutic Discovery and Chief of the Division of Liver Diseases, at the Icahn School of Medicine at Mount Sinai For more information: http://labs.icahn.mssm.edu/friedmanlab/ Dr. Friedman is Chief of Liver Diseases and Dean for Therapeutic Discovery at the Icahn School of Medicine at Mount Sinai. His pioneering research in hepatic fibrosis supported by NIH since 1986, combined with mentoring of over 80 trainees have contributed to the emergence of fibrosis as an exciting new therapeutic area in hepatology. Dr. Friedman was a Senior Fulbright Scholar at the Weizmann Institute, Israel in 1995 and President of the AASLD in 2009. He has received the International Hans Popper and the EASL International Recognition Awards, and is a Fellow of the AASLD, AGA, ACP and AAAS. Yury Popov, MD, PhD Director of Liver Research, Assistant Professor of Medicine at Beth Israel Deaconess Medical Center and Harvard Medical School Yury V. Popov received an M.D. (1997) from Grodno State Medical School, Belarus and PhD in Biochemistry (2004) from Institute of Biochemistry of National Academy of Sciences of Belarus. He became the first scientist from Eastern Europe to win the prestigious Sheila Sherlock EASL fellowship award to pursue postdoctoral training in translational liver fibrosis research at the University of Erlangen-Nuremberg in Germany. In 2005, Dr. Popov relocated to USA to join faculty at Beth Israel Deaconess Medical Center and Harvard Medical School. Dr. Popov is currently directing a Liver Fibrosis Research Lab and Core and holding an appointment of Assistant Professor of Medicine at Beth Israel Deaconess Medical Center and Harvard Medical School. He is also an Associate Editor of American Journal of Physiology-Gastrointestinal and Liver Physiology, and ad hoc reviewer for over 30 scientific journals. Dr. Yury Popov’s laboratory’s major research focus is on liver fibrosis/cirrhosis and its life-threatening sequelae. Specifically, his team investigates the basic mechanisms of progression and regression of liver scarring, with the goal of the development of non-invasive diagnostic tools to measure these processes in the clinic, and novel therapies to prevent and reverse cirrhosis and its lifethreatening complications such as primary liver cancers. Miriam Merad, MD, PhD Professor Oncological Sciences, Professor Medicine, Hematology and Medical Oncology at the Icahn School of Medicine at Mount Sinai For more information: https://icahn.mssm.edu/profiles/miriam-merad Miriam Merad is the Mount Sinai Endowed professor in Cancer Immunology and the Director of the Precision Immunology Institute at Mount Sinai School of Medicine in New York. Dr. Merad also co-leads the Cancer Immunology program at The Mount Sinai Tisch Cancer Institute and is the Director of the Mount Sinai Human Immune Monitoring Center (HIMC). Dr. Merad’s laboratory made seminal discoveries to our understanding of the mechanisms that control the development and functional identity of tissue resident dendritic cells and macrophages during homeostasis, and examining how these regulations are changed in cancer and inflammatory diseases. Dr. Merad has authored more than 170 primary papers and reviews in high profile journals. She receives generous funding from the NIH for her research on innate immunity and their contribution to human disease and belongs to several NIH consortia. In 2018, Dr. Merad received the prestigious William B. Coley Award for Distinguished Research in Tumor Immunology. She is an elected member of the American Society of Clinical Investigation and lectures around the world on her work 35 Gatehouse Drive, A2 Waltham, MA 02451 (781) 996-0955 info@morphictx.com © 2018 Morphic Therapeutic Privacy Statement | Terms of Service