mail@hyphadiscovery.com Search What We Do Products Our Metabolite Expertise Why Choose Us About Us Resources News & Blog Events Contact Us News Latest News Q4 2021 Newsletter – Metabolite identification by PolyCYPs and Kit Offer In our Q4 2021 technical newsletter we describe how Hypha used PolyCYPs to help the Open Source Antibiotics team identify a drug metabolite. READ MORE Q3 2021 Newsletter – Glucuronide and glucoside synthesis We look at the synthesis of glucuronides and glucose conjugates in our Q3 2021 technical newsletter. READ MORE Q2 2021 Newsletter – Deuterated metabolites We discuss the synthesis of deuterated metabolites and purification of metabolites from complex mixtures in our Q2 2021 newsletter. READ MORE Samuel Coe joins Hypha’s Business Development Team We’re pleased to welcome Dr Samuel Coe to the team at Hypha as Business Development Manager. Samuel is a medicinal chemist by training having previously worked in the pharma space for Vertex, Charnwood Molecular and Evotec. READ MORE EFMC-ISMC 2021 presentation on biocatalysis and late-stage functionalisation Frank will be giving a talk at the EFMC-ISMC 2021 meeting on “Integration of Biocatalysis into Medicinal Chemistry Programs for Late-Stage Oxidised Derivatives using PolyCYPs Enzymes” READ MORE Client Project Success using One-Stop Metabolite Shop We’re proud of our team for the recent successful delivery of a client project using Hypha’s One-Stop Metabolite Shop approach. Metabolites of two drug substances were provided, using microbial biotransformation for one drug compound and late-stage chemical synthesis for the other. READ MORE PolarExplorer project success We always really appreciate receiving feedback from a client. This time we celebrate project success for Alkermes for whom we used our PolarExplorer platform to deliver novel hydroxylated derivatives of some of their lead compounds. PolarExplorer uses Hypha’s PolyCYPs enzymes to create multiple hydroxylated derivatives of drugs in parallel. READ MORE Q1 2021 newsletter – N-glucuronide metabolites, on the rise? Our newsletter for Q1 2021 features a commentary on the perceived increase in requests to access N-glucuronides, as well as highlighting Hypha’s solutions for synthesising and characterizing these and other types of glucuronide metabolites, as part of the tools in our One-Stop Metabolite Shop approach. READ MORE Challenging metabolite synthesis project success Project Manager and Head of Chemistry Richard Phipps, together with Hypha scientists Renia Gemmell, Chloe Herring and Chris Drake have received great feedback for the successful completion of a challenging metabolite project for a US pharma client. The project involved multiple disciplines of microbial biotransformation, purification and structure elucidation. READ MORE More great client feedback We’ve received some more positive feedback from one of our US pharma clients. Here’s what our client had to say: READ MORE Welcome to our new team members at Hypha We were delighted to welcome some new recruits to the Hypha family this October. Chloe Herring and John Boyle join the Chemistry team and Charlotte Woods joins the Microbiology team. READ MORE Hypha publishes review article on the impact of metabolism in drug discovery Hypha’s paper in ACS Medicinal Chemistry Letters on “Biotransformation: Impact and Application of Metabolism in Drug Discovery” was published in August 2020. READ MORE Previous Next Stay up to date with the latest news from Hypha Discovery Sign up for our Newsletter to receive interesting updates and scientific case studies about Hypha’s metabolite generation capabilities and lead optimization solutions Subscribe now Ready to begin? Our scientists are available to talk through your requirements Contact Us Submit Hypha Discovery is a UK-based CRO supporting pharmaceutical and agrochemical companies worldwide through the production of metabolites and new derivatives of drugs and agrochemicals in discovery and development. What We Do Metabolite Synthesis Purification Structure Elucidation & NMR Certificates of Analysis Late Stage Functionalisation Custom Natural Product Synthesis Contract Fermentation Our Products PolyCYPs+ Kits for Metabolites PolyCYPs Kits for Late-Stage Oxidation PolyCYPs+ Kit Instructions Human AOX Human FMOs Our Science One-Stop Metabolite Shop Late Stage Chemical Synthesis Mammalian Biotransformations Microbial Biotransformation Purification & Structure Elucidation Recombinant Enzymes Resources Brochures Case Studies Publications Cookie Policy | Privacy Policy | Website Terms and Conditions | Sitemap © Hypha Discovery 2021. All Rights Reserved. Website by Fifteen.co.uk We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it.OkPrivacy policy