Home Drug Product Development & Manufacturing You are here Contact us Highlights Bioavailability enhancement If you’re facing solubility challenges that impact your drug candidate’s reproducible absorption in the gastrointestinal tract, Ardena can help. In such cases where poor drug substance solubility is limiting oral bioavailability, formulation techniques can be applied to increase the dissolution rate and/or apparent solubility at the site of absorption. Ardena offers solubility-enhancing methods and technologies, including: Nanosuspensions Amorphous solid dispersions Lipid-based formulations Our science-based approach to formulation eliminates the trial-and-error strategy seen in traditional product development strategies. We use screening to identify the most effective formulation technology for your compound. These formulations are developed in our formulation laboratory and finally transitioned into our GMP-production facility. This approach minimises DS consumption and saves our customers time and money. Modified release Ardena has range of delayed or controlled release technologies that are used to develop monolithic or multi-particulate matrix-type and reservoir-type systems. These include: Bead layering Spray drying Minitablet compression Matrix tablet compression Tablet coating Biorelevant dissolution During drug development, the selection of the most effective formulation must be supported by effective biorelevant dissolution testing. It is important that the media used in these dissolution setups are representative of the human gastrointestinal fluids. At Ardena, we have expertise in a broad range of biorelevant dissolution techniques, including the use of two-phase systems and flow-through methodologies. Back to drug product development & manufacturing Services Highlights Capabilities Contact us today Drug Substance Development & Manufacturing Drug Product Development & Manufacturing Clinical Logistics Bioanalysis Dossier Development Get in touch with us to discuss your next project Register for our newsletter Do you wish to remain up to date with drug development insights, industry trends & Ardena news? Click here to register Services Drug Substance Solid State Research Drug Product Clinical Logistics Bioanalysis Dossier Development Nanomedicine Navigation About Us Careers News & Insights Contact Legal entities General Terms and Conditions Contact details Ardena Kleimoer 4 B-9030 Mariakerke Belgium Telephone +32 9 267 65 00 Fax: +32 9 267 65 10 © Ardena Holding NV 2021 LinkedIn Sitemap Privacy Policy Ardena respects your right to privacy Your ability to make informed choices about the use of your information is important to us. This cookie statement details which cookies we or other parties can place on your device and how we and other parties use this information within Ardena. If you have any comments or questions about this cookie statement or the collection and use of your personal data, please contact our data protection GDPR@ardena.com More info. Set preferences Accept cookies