Comprehensive Synthetic Process R&D Whether you need help with MedChem, expertise in new route scouting and process R&D before manufacturing clinical supplies, or simply need small amounts of compound synthesized, Cascade Chemistry is here for you. In our 14,000 foot facility based in Eugene, Oregon we have 15 R&D hoods and 3 kilo suites with capabilities from gram scale to 100L reactors that produce up to 10kg batches and, using a multi-batching approach, up to 40kg. With over 40 years in business and a bench of expert scientists, 75% holding a PhD, that stay with the project from synthesis to cGMP, we’ve solved a range of complex chemistry challenges for our clients. Our capabilities include: New Route Development. Our team’s deep experience with retrosynthetic analysis provides thoughtful new approaches to synthetic route development. Process R&D and Critical Process Parameters. Gain the flexibility and experience necessary to optimize a single reaction or rework of a 17-step synthesis, all while focusing on safe, cost effective, and scalable chemistry. We optimize processes for our facility as well as processes running at other CDMOs. Impurity and Cold Label Standards. Join a wide range of pharmaceutical clients, including multinational generics companies, who trust us for single programs or ongoing engagements. Medicinal Chemistry. Get help with new synthetic routes, intermediate synthesis, lead scale-up, and patent coverage. Scale-Up. From gram scale to Phase 2 cGMP manufacturing, you’ll work with the same team in the same facility. Chemical Specialties. These include Transition Metal Catalysis, Asymmetric Synthesis, Heterocycles, Protecting Group Strategies, and Solid Phase Synthesis. Why Cascade Chemistry for Synthetic Services Deep Scientific Expertise – We’ve been solving complex chemistry for over 40 years, and our chemists are experts – more than 75% hold PhDs and have an average of 16 years on the bench. Broad Experience across Compound Classes – Over the years we’ve worked in many different classes of compounds from prostaglandins to heterocycles. We aren’t afraid of lengthy syntheses with carbon-carbon bond formations, asymmetric syntheses, and development of protecting group strategies. Built-in Quality – We build quality into our approach from the start, whether we are running your cGMP project or working on your process R&D challenges. Our dedicated quality team and quality-first approach reduce risk and costs later on. Additionally, in the current COVID-19 environment, we are offering customers virtual audits to provide peace of mind for both employee safety and project success. True Partnership – You will have access to senior management and the core scientific team no matter the size of your project. Our support team includes a fully integrated quality and analytical team with a reporting and communication framework that is customized for your needs. Efficiency from Research to Lab – Our chemists are with your project from Day One and every step of the way from synthesis through to API manufacturing for clinical Phase 1 and 2. With Cascade Chemistry, the transfer from the lab to clinic is seamless. Results for Our Clients Our clients have received over 30 patents and many – two-thirds – stay with us for more than one project. Here’s just one example why: Bay Area Pharmaceutical Company with a portfolio of therapeutics Overview: A small pharma company needed help with a MedChem program to develop leads, develop a scalable process, and then manufacture materials for clinical trials. Outcome: Cascade executed a MedChem program, developed a manufacturing route, made material for GLP tox studies, and finally manufactured Phase 1 and Phase 2 GMP batches. A second MedChem program has progressed through GLP and GMP Phase 1 manufacturing. A third MedChem program is underway. Our Difference: Worked creatively with a small client to stretch finances to get project to completion. Collaborated closely with the customer’s MedChem team. Our MedChem experience helped client to get to the compounds they needed, while expertise with scale-up and GMP got the customer to the clinic. When Can We Start? Call us at 541-484-2387 to discuss your requirements and timeline and find out more about our services and team or contact us to get started today. CONTACT Cascade Chemistry By Aceto 90 North Polk St Suite 200 Eugene, OR 97402 541-484-2387 Email Us SEARCH FOR A PRODUCT… CASE STUDY New Synthetic Route Accelerates Client into the Clinic WHITE PAPER Going from Process R&D to Clinical APIs Quickly and Effectively JOIN THE GROWING ACETO TEAM View Careers © 2021 - All Rights Reserved. Site design by Brandwidth Solutions. Join the growing Aceto teamView Our Careers Page