NuVasive NUVASIVE BIOLOGICS The NuVasive Biologics portfolio includes procedurally integrated allogeneic bone graft substitutes and extenders, and synthetic ceramic bone graft substitutes intended to promote bone fusion. Information you need When fusion is recommended Fusion is primarily performed to eliminate the pain often caused by abnormal motion of the vertebrae. Fusion is a surgical procedure in which one or more of the vertebrae of the spine are joined together (fused) so that motion no longer occurs between them. Bone grafting is a surgical technique that involves implanting a bone substitute or extender to help the body achieve spinal fusion. The three essential biologic mechanisms involved in complete bone grafts include osteoconduction (a scaffold for the reparative growth of the natural bone), osteoinduction (signals encouraging undifferentiated cells to become active osteoblasts), and osteogenesis (living bone cells in the graft material contribute to bone remodeling). Osteocel® family Building on a heritage of scientific expertise and clinical experience, over 225,000 patients have been treated with Osteocel bone grafts.1 Osteocel is a comprehensive bone graft developed to mimic the properties of a patient's own bone. Osteocel provides a complete and physiologic bone graft that contains all of the necessary components for bone growth: the cells, the signals, and the scaffold. Osteocel plus Osteocel pro Osteocel patient brochure Osteocel is human tissue donated specifically for human clinical use. Attrax® family The Attrax ceramic surface has unique microstructure and microporosity that are optimized for bone formation. The unique microarchitecture of Attrax drives the differentiation of mesenchymal stem cells (MSCs) into bone-forming osteoblasts without added growth factors.2 The optimized microarchitecture of Attrax is engineered using tightly controlled parameters for a defined micropore size distribution within 0.3 to 1.1 microns, demonstrated to initiate greater bone formation compared to traditional ceramics.3 Attrax scaffold Attrax putty Learn more about Attrax Propel™ family Propel DBM is donated human bone that has been demineralized to remove the minerals and cells contained in the bone while retaining the collagen matrix and growth factors, including bone morphogenetic proteins, inherent to the tissue. Propel DBM Putty and Gel serve as a bone graft extender (extremities, spine, pelvis) and bone void filler of the extremities and pelvis. Propel DBM Putty Plus and Gel Plus contain added cancellous chips and serve as a bone graft extender (extremities, posterolateral spine, pelvis) and bone void filler of the extremities and pelvis. Propel DBM Fibers and Propel DBM Sponge are 100% bone and are intended for homologous use in the repair, replacement, or reconstruction of skeletal defects. Propel DBM putty & gel Propel DBM putty plus & gel plus Propel DBM fibers Propel DBM sponge 1. As of date of publication, March 2017; data on file. 2. Polini A, Pisignano D, Parodi M, et al. Osteoinduction of human mesenchymal stem cells by bioactive composite scaffolds without supplemental osteogenic growth factors. PLoS ONE 2011;6(10):1-8. 3. Duan R, Barbieri D, Luo X, et al. Variation of the bone forming ability with the physicochemical properties of calcium phosphate bone substitutes. Biomater Sci 2018;6:136-45. SOLUTIONS PROCEDURES CONDITIONS RESOURCES ABOUT INVESTOR RELATIONS CAREERS CONTACT 7475 Lusk Blvd. San Diego, CA 92121 USA Toll Free 800-455-1476 Main 858-909-1800 FAX 800-475-9134 info@nuvasive.com facebook instagram twitter linkedin youtube The materials on this website are for your general educational information only. Information you read on this website cannot replace the relationship that you have with your healthcare professional. We do not practice medicine or provide medical services or advice as a part of this website. You should always talk to your healthcare professional for diagnosis and treatment. Cookie Settings Terms & Conditions Privacy ©2021 NuVasive®, Inc. We use cookies to deliver the best browsing experience, personalize content, service targeted advertisements and analyze site traffic. You can find out more or disable specific cookies by clicking “Cookie Settings.” You can withdraw your consent at any time using the Cookie Settings link in the footer of our website. Cookie Settings Accept Only Necessary Cookies Accept All Cookies