ABOUT COMPANY PRODUCTS DISTRIBUTORS PRESS CENTER SHAREHOLDERS NEWS CONTACTS ENGLISH QUESTION ANSWER ALLOPURINOL Active ingredient: allopurinol. Pharmacological action: anti-gout agent, inhibiting xanthine oxidase, prevents the transition of hypoxanthine to xanthine and further formation of uric acid from it. Reduces the concentration of uric acid and its salts in body fluids, helps dissolve existing urate deposits, and prevents their formation in tissues and kidneys. Reducing the transformation of hypoxanthine and xanthine, enhances their use for the synthesis of nucleotides and nucleic acids. Indications:diseases accompanied by hyperuricemia (treatment and prevention): gout (primary and secondary), urolithiasis (with the formation of urates). Hyperuricemia (primary and secondary), which occurs in diseases accompanied by increased disintegration of nucleoproteins and an increase in the content of uric acid in the blood, incl. with various hematoblastosis (acute leukemia, chronic myeloid leukemia, lymphosarcoma, etc.), with cytostatic and radiation therapy of tumors (including in children), psoriasis, extensive traumatic injuries due to enzyme disorders (Lesch-Nyhan syndrome), and with massive therapy with glucocorticosteroids, when, due to the intensive breakdown of tissues, the amount of purines in the blood significantly increases. Uric acid nephropathy with impaired renal function (renal failure). Method of administration and dosage: inside, after meals, with plenty of water. The daily volume of urine should be more than 2 liters (urine reaction is neutral or slightly alkaline). The daily dose of more than 300 mg must be divided into several doses. Adults: the appointment of the drug for a mild course of the disease is carried out in a daily dose of 100-200 mg; for diseases of moderate severity - 300-600 mg / day; in severe cases - 700-900 mg / day. In terms of body weight, you can give 2-10 mg / kg per day. To prevent urate nephropathy during anticancer therapy, allopurinol is prescribed in a daily dose of 600-800 mg for 2-3 days with the continuation of the maintenance dose. Children:from 10 to 15 years old, appoint 10-20 mg / kg / day or 100-400 mg per day, for children under 10 years old, 5-10 mg / kg / day. Allopurinol is rarely used in pediatric therapy. The exception is malignant oncological diseases (especially leukemia) and some enzymatic disorders (for example, Lesch-Nyhan syndrome). Contraindications: according to the instructions. Adverse reactions: according to the instructions. Special instructions: according to the instructions. Release form: tablets 100 mg No. 50, 300 mg No. 30. Consult your doctor before use. For more information, see the instructions for use.