About News Contact Careers Europe, Middle East & Africa Terumo Global Products EventsLearning Search HomeMedical fieldInterventional OncologyQuiremSpheres® Microspheres QuiremSpheres® Microspheres Description Characteristics Preparation Clinical evidence General specifications Item specifications Downloads References Description The Holmium Platform: Delivering Individualized Treatment to the Right Patient The Holmium Platform delivers a first in SIRT: a comprehensive end to end platform for treating unresectable liver tumours. The Holmium Platform consists of three integrated products that allow you to select patients with confidence, deliver treatment with precision ad plan and verify with accuracy. QuiremScout®: The first SIRT work-up product that uses the same technology as the therapeutic microspheres, to optimize patient selection and advance treatment planning Quiremspheres®: The only therapeutic SIRT microsphere that is used as part of a fully integrated platform, to improve patient outcomes and advance the future of SIRT Q-SuiteTM: Dedicated Holmium-166 software for individualized treatment planning Accurate post treatment dosimetry to verify the radiation dose delivered Characteristics SIRT with the Holmium Platform QuiremSpheres® and QuiremScout® consist of Holmium-166 microspheres that offer unique imaging capabilities Q-SuiteTM: dedicated holmium-166 software for individualized treatment planning: Treatment Activity Planning as recommended in QuiremSpheres® instructions for use Lung Dose Prediction based on SPECT after QuiremScout® and/or Tc-99mMAA Pre-Treatment Dose Simulation - multi-compartment treatment planning based on QuiremScout® and/or Tc-99mMAA Innovation with Holmium The short half life of Holmium-166 in QuiremSpheres® ensures delivery of a high dose rate (90% of radiotherapy dose delivered within 4 days) Clinical evidence and treatment Clinical evidence demonstrates that QuiremSpheres® are efficacious (1) well tolerated (2) and safe (1-3) for the treatment of unresectable liver cancer. “With QuiremSpheres® we see the majority of our patients responding much quicker than what we are used to seeing with Yttrium-90” Dr. Irene Bargellini, Head of Radiology, Cuneo Hospital Post-treatment Visualization and Quantification Holmium-166 microspheres allow for post-treatment visualization and quantification using MRI and SPECT, for further analysis in Q-SuiteTM “QuiremSpheres® gives us the confidence we need to start individualizing treatments” Prof. Dr. Ralf-Thorsten Hoffmann, Head of Interventional Radiology, University Hospital Dresden Q-SuiteTM Q-SuiteTM: accurate post-treatment dosimetry to verify the radiation dose delivered Dose Reconstruction based on quantitative Holmium-166 MRI or SPECT Evaluation of Dose absorbed in tumour and in healthy liver tissue Deliver with ease QuiremSpheres® and QuiremScout® use the same intuitive and efficient administration system The system is easy to learn – it has been developed in collaboration with leading SIRT physicians and incorporates features that you may already be familiar with if you have performed SIRT. Preparation Video instructions Clinical evidence The Holmium Platform Quality of life in patients with liver tumors treated with holmium‑166 radioembolization First evidence for a dose-response relationship in patients treated with 166Ho-radioembolization: a prospective study See all clinical evidence General specifications QuiremSpheres® is supplied as a standard dose in a single capped V-vial or as a standard dose divided among several capped V-vials. Characteristics QuiremSpheres® Other SIRT products Isotope Holmium-166 Yt-90 Beta-radiation (Emax) 1.77 MeV (48.7%) 1.85 MeV (50.0%) 2.28 MeV Gamma-radiation 81 keV (6.7%) - Visible on MRI Yes No Half-life 26.8 hours 64.1 hours Material Poly(L-lactic acid) Resin (r) or glass (g) Diameter 15-60 μm 20-60 μm (r) 20-30 μm (g) Density 1.4 g/cm3 1.6 g/cm3 (r) 3.3 g/cm3 (g) Q-Suite™ Software Requirements Hardware Recommendations x64 based computer running Microsoft Windows 7, 8.1 or 10 Microsoft .NET version 4.5.2 framework should be installed Dual-core CPU, 2.0GHz or higher 16 GB RAM SSD with 20 GB free disk space Item specifications Item reference Material description Description QS-V001 Holmium-166 microspheres,QuiremSpheres® V-vial containing a patient-specific dose of QuiremSpheres® QS-C001 Customer kit Set of re-usable administration box and accessories for administration of QuiremSpheres® QS-D001 Delivery set Set of sterile single-use tube lines for administration of QuiremSpheres® (in a carton of 6 pieces) Enlarge table Item reference Material description Description 8QSQ002 Q-Suite™ Holmium 166 SIRT planning & post-treatment verification software Enlarge table QuiremSpheres® is a product manufactured by Quirem Medical B.V. and has CE-mark. QuiremSpheres® is not available for sale in all countries. This information is provided only in respect to markets where the product is approved or cleared. QuiremSpheres® is not FDA cleared in the US for sale. QuiremSpheres® is not approved in Canada Downloads Relevant product information The Holmium Platform References 1 HEPAR I: Smits et al, 2012 Lancet Oncology 2 HEPAR II: Prince et al, 2017 Journal of Nuclear Medicine Do you need more info about this product? Our sales representatives are here for you. Contact us Related products Previous Glidesheath Slender® Introducer Radifocus® Guide Wire M Non-Vascular Guide Wire TR Band® Radial Artery Compression Device Angio-Seal™ Evolution™ Vascular Closure Device Radifocus® Introducer II Radiopaque Marker Kit C Introducer Sheath Next 1 2 Didn't find your product? 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