WORLDWIDE CONTACT US ABOUT US INVENTING FOR LIFE PRODUCTS RESEARCH LICENSING NEWSROOM CAREERS INVESTORS Home HUMANS FOR HEALTH Curiosity, inventiveness, and a passion for excellence. These are qualities that drive Merck people to discover what’s possible as they work to help improve health around the world. See our latest story "It's Personal" Series "Women in Science" Series Faces of the Future "Everybody comes to work from a different place...We want to use that unique perspective to further the business." Jay Schiller "What is most exciting is to be able to invent a new sort of chemical reaction one day, and use it in drug discovery the next day. And that’s just something that doesn’t happen in academia." Spencer Dreher Interested in joining Merck's mission to save and improve lives? Review open job postings! Copyright. © 2009-2018 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. All rights reserved. Forward-Looking Statement Privacy Terms of Use Site Map

WORLDWIDE CONTACT US ABOUT US INVENTING FOR LIFE PRODUCTS RESEARCH LICENSING NEWSROOM CAREERS INVESTORS Home PERSPECTIVES NEW THERAPIES MEAN NEW WAYS TO ATTACK INFECTIONS A Point of View by Todd Black, Ph.D., executive director, Infectious Diseases The time has come to change tactics in the fight against drug-resistant infections.” Todd Black In my career, I’ve reviewed case reports featuring images of patients with severe systemic mold infections, often manifested by skin lesions and mushroom-like fruiting bodies, as well as the devastating effects of the aggressive surgery that some of these patients must undergo in order to survive. Seeing this makes one realize just how important it is to find new, non-surgical therapies to treat these difficult infections. Luckily, these fungal infections, which have limited treatment options, are relatively rare. However, for more common bacterial infections, a similar lack of treatment options is also becoming a reality, due the development and spread of antibiotic resistance. Focusing on new approaches The time has come to change tactics in the fight against drug-resistant infections as well as helping to preserve existing treatment options. It is critical that we find new approaches, but the path of discovery has proven to be more challenging than scientists and researchers have imagined. Unfortunately, we may continue to be humbled by the possibility that a new “penicillin” will never be created or discovered again. It is important that we focus on understanding the bacterial barriers, defenses and the chemical properties that are required to selectively kill the pathogens. One alternative is to better understand and then attempt to modulate the host's response to an infection. As we learn more about the body’s immune responses, the possibility improves for finding different ways to help the body fight the infection. AN ADDITIONAL PERSPECTIVE Dalya Guris, executive director, Clinical Research, Merck Research Laboratories Published August 2015 Copyright. © 2009-2018 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. All rights reserved. Forward-Looking Statement Privacy Terms of Use Site Map