Company Investors Technology Careers Updates Events Contact Technology We believe that we have a cutting edge technology with the potential to revolutionise treatment using mRNA targeted therapies Pipeline Overview Exonate is leveraging our expertise in our revolutionary, mRNA targeted, small molecule compounds. Our lead programme, for the treatment of Diabetic Macular Oedema (DMO), has entered Phase I clinical trials and we are actively developing targeted therapies across a range of diseases. How Our Drugs Work Drugs which inhibit VEGF and its receptors are already the standard of care for a number of diseases including wAMD and DMO and is a mainstay of cancer therapy. VEGF is alternatively spliced into two classes of protein: pro-angiogenic VEGF-Axxxa isoforms which are responsible for disease progression, and anti-angiogenic VEGF-Axxxb isoforms which mitigate these effects through competitive binding. Current therapies, however, target all isoforms of VEGF, are associated with limited efficacy, resistance, off-target effects and toxicity. Modulation of VEGF splicing using our novel compounds aims to reduces pathological VEGF, angiogenesis and disease progression without inhibiting non-pathological, protective forms of VEGF, and so has the potential to offer safer, more efficacious therapies. What is happening at Exonate? Learn more about Exonate and discover our latest company news, achievements and discoveries. Don’t miss a thing and get updated on our latest news. SEE ALL UPDATES Who we are Exonate is a biopharmaceutical company focused on the discovery and development of small molecule drugs that modulate alternative mRNA splicing to address diseases of high unmet medical need. Alternative mRNA splicing is modulated in disease states resulting in pathological blood vessel formation (angiogenesis) This is a key driver of disease progression in some ophthalmic conditions and cancers. Follow us on Social Media Useful links Career opportunities Technology Investors Contact Copyright © 2021 Exonate Privacy policy Designed and built by Onespacemedia