≡ YOU ARE HERE HOME » SCIENCE » SCIENTIFIC AREAS GENOME REGULATION, CELLULAR CIRCUITRY AND EPIGENOMICS We build comprehensive models of cell and tissue circuits in order to understand how human disease arises from variations in these processes. We monitor the activities of many molecular elements that define and regulate the cell, including DNA, RNA, transcription factors, chromatin regulators, histone modifications, and signaling proteins. In disease, a key gene regulator could be missing or defective. A critical epigenetic mark could be miswritten. A key circuit might be over- or under-active. We use a diverse set of tools — including genetic perturbations and genome- and proteome-wide measurements — to decipher the functions of coding and non-coding regions of the genome and study cellular circuitry, with a strong emphasis on the analysis of single cells. People Bradley E. Bernstein Nir Hacohen Cigall Kadoch Jason D. Buenrostro GENOME REGULATION, CELLULAR CIRCUITRY AND EPIGENOMICS About Cell Circuits and Complex Tissues Epigenomics Gene Regulation Observatory (GRO) RECENT PUBLICATIONS Parallel Single-Cell RNA-Seq and Genetic Recording Reveals Lineage Decisions in Developing Embryoid Bodies. Expanded encyclopaedias of DNA elements in the human and mouse genomes. Perspectives on ENCODE. Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs. Resolving medulloblastoma cellular architecture by single-cell genomics. Other Genome regulation, cell circuitry, and epigenomics Publications RELATED TUMORS HIDE FROM THE IMMUNE SYSTEM WITH HELP FROM THIS PROTEIN Read More NEWS AT THE BROAD ALL NEWS NEWS / 10.12.21 René Salazar joins Broad Institute as Chief Equity Officer READ MORE NEWS / 10.13.21 Mapping the effects of genetic variation, one letter at a time READ MORE NEWS / 11.15.21 Artificial intelligence–based method predicts risk of atrial fibrillation READ MORE NEWS / 10.6.21 Richard Merkin, M.D., renews support for transformative science at Broad READ MORE CAREERS GIVING NEWS AND MEDIA CONTACT US PRIVACY POLICY Copyright © 2021 Broad Institute. All rights reserved. TWITTER FACEBOOK YOUTUBE INSTAGRAM