Advertisement Advertisement Sign In » Advanced Search » Home Current Issue Papers in Press Editors' Picks Reflections Minireviews Papers in Press JBC Papers in Press are papers in manuscript form which have been accepted but which have not been copyedited and not yet appeared in a regular issue of the journal. Copyediting may lead to small differences between the Papers in Press version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article’s unique Digital Object Identifier (DOI). October 4, 2017 Molecular Biophysics - Protein Structure and Folding: Carol S. Bookwalter, Chwen L. Tay, Rama McCrorie, Michael J. Previs, Hailong Lu, Elena B. Krementsova, Patricia M. Fagnant, Jake Baum, and Kathleen M. Trybus Reconstitution of the core of the malaria parasite glideosome with recombinant Plasmodium class XIV myosin A and Plasmodium actin J. Biol. Chem. jbc.M117.813972. doi:10.1074/jbc.M117.813972 Abstract PDF Supplemental Data Microbiology - Molecular Bases of Disease: Junfeng Sun, Zongxi Han, Tianming Qi, Ran Zhao, and Shengwang Liu Chicken galectin-1B inhibits Newcastle disease virus adsorption and replication through binding to HN glycoprotein J. Biol. Chem. jbc.M116.772897. doi:10.1074/jbc.M116.772897 Abstract PDF Supplemental Data Microbiology - Protein Structure and Folding: Kosuke Oda, Takashi Oda, Yasuyuki Matoba, Masaru Sato, Takashi Irie, and Takemasa Sakaguchi Structural analysis of the STAT1-STAT2 heterodimer revealed the mechanism of Sendai virus C protein-mediated blockade of type 1 interferon signaling J. Biol. Chem. jbc.M117.786285. doi:10.1074/jbc.M117.786285 Abstract PDF Supplemental Data Genomics and Proteomics - Protein Synthesis and Degradation: Cheng-Kang Chiang, Aleksander Tworak, Brian M. Kevany, Bo Xu, Janice Mayne, Zhibin Ning, Daniel Figeys, and Krzysztof Palczewski Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium J. Biol. Chem. jbc.M117.812677. doi:10.1074/jbc.M117.812677 Abstract PDF Supplemental Data Molecular Bases of Disease - Gene Regulation: Young-Kyoung Lee, Jin J Lim, Un-woo Jeoun, Seongki Min, Eun-beom Lee, So Mee Kwon, Changhan Lee, and Gyesoon Yoon Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness J. Biol. Chem. jbc.M117.809012. doi:10.1074/jbc.M117.809012 Abstract PDF October 3, 2017 Signal Transduction - Enzymology: Akihiro Nakanishi, Naoya Hatano, Yuya Fujiwara, Arian Bin Shari, Shota Takabatake, Hiroki Akano, Naoki Kanayama, Masaki Magari, Naohito Nozaki, and Hiroshi Tokumitsu AMP-activated protein kinase-mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β J. Biol. Chem. jbc.M117.805085. doi:10.1074/jbc.M117.805085 Abstract PDF Supplemental Data Signal Transduction - Molecular Bases of Disease: Anna Maria Knittle, Maria Helkkula, Mark S Johnson, Maria Sundvall, and Klaus Elenius Sumoylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the erbb4 receptor tyrosine kinase J. Biol. Chem. jbc.M117.794271. doi:10.1074/jbc.M117.794271 Abstract PDF Supplemental Data Signal Transduction - Cell Biology: Stanley M Kanai, Alethia J Edwards, Joel G Rurik, Patrick Osei-Owusu, and Kendall J Blumer Proteolytic degradation of Regulator of G Protein Signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction J. Biol. Chem. jbc.M117.797134. doi:10.1074/jbc.M117.797134 Abstract PDF Author'S Choice Methods and Resources: Tracey L Weissgerber, Marko Savic, Stacey J Winham, Dejana Stanisavljevic, Vesna D. Garovic, and Natasa M Milic Data Visualization, Bar Naked: A Free Tool for Creating Interactive Graphics J. Biol. Chem. jbc.000147.2017. doi:10.1074/jbc.RA117.000147 Abstract PDF Signal Transduction - Cell Biology: Yoshihiro Umezawa, Hiroki Akiyama, Keigo Okada, Shinya Ishida, Ayako Nogami, Gaku Oshikawa, Tetsuya Kurosu, and Osamu Miura Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1) J. Biol. Chem. jbc.M117.779603. doi:10.1074/jbc.M117.779603 Abstract PDF Protein Structure and Folding - Molecular Bases of Disease: Sanaz Rasouli, Alireza Abdolvahabi, Corbin M. Croom, Devon L. Plewman, Yunhua Shi, Jacob I. Ayers, and Bryan F. Shaw Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding J. Biol. Chem. jbc.M117.805283. doi:10.1074/jbc.M117.805283 Abstract PDF Supplemental Data RNA - Gene Regulation: Adam Idica, Evgueni A Sevrioukov, Dimitri G Zisoulis, Matthias Hamdorf, Iben Daugaard, Pavan Kadandale, and Irene Munk Pedersen microRNA miR-128 represses LINE-1 retrotransposition by downregulating the nuclear import factor TNPO1 J. Biol. Chem. jbc.M117.807677. doi:10.1074/jbc.M117.807677 Abstract PDF Supplemental Data Enzymology: Yindi Chu, Tao Tu, Leena Penttinen, Xianli Xue, Xiaoyu Wang, Zhuolin Yi, Li Gong, Juha Rouvinen, Huiying Luo, Nina Hakulinen, Bin Yao, and Xiaoyun Su Insights into the roles of non-catalytic residues in the active site of a GH10 xylanase with activity on cellulose J. Biol. Chem. jbc.M117.807768. doi:10.1074/jbc.M117.807768 Abstract PDF Supplemental Data October 2, 2017 Minireview - Bioenergetics - Microbiology: Cory J Knoot, Justin L Ungerer, Pramod P. Wangikar, and Himadri B Pakrasi Cyanobacteria: promising biocatalysts for sustainable chemical production J. Biol. Chem. jbc.R117.815886. doi:10.1074/jbc.R117.815886 Abstract PDF Protein Synthesis and Degradation - Protein Structure and Folding: Ligia Acosta-Sampson, Kristina Döring, Yuping Lin, Vivian Y Yu, Bernd Bukau, Günter Kramer, and Jamie H D Cate Role for Ribosome-Associated Complex and Stress-Seventy subfamily B (RAC-Ssb) in integral membrane protein translation J. Biol. Chem. jbc.M117.813857. doi:10.1074/jbc.M117.813857 Abstract PDF Supplemental Data Protein Structure and Folding - Molecular Biophysics: Do-Hwan Ahn, Ki-Young Lee, Sang Jae Lee, Sung Jean Park, Hye-Jin Yoon, Soon-Jong Kim, and Bong-Jin Lee Structural analyses of the MazEF4 toxin-antitoxin pair in Mycobacterium tuberculosis provide evidence for a unique extracellular death factor J. Biol. Chem. jbc.M117.807974. doi:10.1074/jbc.M117.807974 Abstract PDF Supplemental Data Enzymology: Christoph Loderer, Venkateswara Rao Jonna, Mikael Crona, Inna Rozman Grinberg, Margareta Sahlin, Anders Hofer, Daniel Lundin, and Britt-Marie Sjöberg A unique cysteine-rich Zn-finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover J. Biol. Chem. jbc.M117.806331. doi:10.1074/jbc.M117.806331 Abstract PDF Supplemental Data Metabolism: Julien Lamontagne, Anfal Al-Mass, Christopher J. Nolan, Barbara E. Corkey, S. R. Murthy Madiraju, Erik Joly, and Marc Prentki Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) β-cells using metformin-induced metabolic deceleration as a model J. Biol. Chem. jbc.M117.808105. doi:10.1074/jbc.M117.808105 Abstract PDF Metabolism - Molecular Bases of Disease: Kathleen A Hershberger, Dennis M Abraham, Angelical S Martin, Lan Mao, Juan Liu, Hongbo Gu, Jason W Locasale, and Matthew D Hirschey Sirtuin 5 is required for mouse survival in response to cardiac pressure overload J. Biol. Chem. jbc.M117.809897. doi:10.1074/jbc.M117.809897 Abstract PDF Supplemental Data Protein Structure and Folding - Enzymology: Yogesh B Khandokar, Parul Srivastava, Nathan Cowieson, Subir Sarker, David Aragao, Shubagata Das, Kate M Smith, Shane R Raidal, and Jade K Forwood Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase J. Biol. Chem. jbc.M117.800227. doi:10.1074/jbc.M117.800227 Abstract PDF September 29, 2017 Cell Biology - Signal Transduction: Hiba Sabra, Molly Brunner, Vinay Mandati, Bernhard Wehrle Haller, Dominique Lallemand, Anne-Sophie Ribba, Genevieve Chevalier, Philippe Guardiola, Marc R Block, and Daniel Bouvard β1 integrin dependent Rac/group I PAK signaling mediates YAP activation of Yes associated protein 1 (YAP1) via NF2/merlin. J. Biol. Chem. jbc.M117.808063. doi:10.1074/jbc.M117.808063 Abstract PDF Supplemental Data Cell Biology: Pankaj Sehgal, Paula Szalai, Claus Olesen, Helle A. Praetorius, Poul Nissen, Søren Brøgger Christensen, Nikolai Engedal, and Jesper Vuust Møller Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response J. Biol. Chem. jbc.M117.796920. doi:10.1074/jbc.M117.796920 Abstract PDF Supplemental Data Membrane Biology - Molecular Biophysics: Hyunjong Byun, Jiyeon Park, Sun Chang Kim, and Jung Hoon Ahn A lower isoelectric point increases signal sequence−mediated secretion of recombinant proteins through a bacterial ABC transporter J. Biol. Chem. jbc.M117.786749. doi:10.1074/jbc.M117.786749 Abstract PDF Supplemental Data Neurobiology - Molecular Bases of Disease: H.M. Mazhar Asjad, Ameya Kasture, Ali El-Kasaby, Michael Sackel, Thomas Hummel, Michael Freissmuth, and Sonja Sucic PHARMACOCHAPERONING IN A DROSOPHILA MODEL SYSTEM RESCUES HUMAN DOPAMINE TRANSPORTER VARIANTS ASSOCIATED WITH INFANTILE/JUVENILE PARKINSONISM J. Biol. Chem. jbc.M117.797092. doi:10.1074/jbc.M117.797092 Abstract PDF Plant Biology - Enzymology: Baptiste Pierman, Frederic Toussaint, Aurelie Bertin, Daniel Levy, Nicolas Smargiasso, Ewin De Pauw, and Marc Boutry Activity of the purified plant ABC transporter NtPDR1 is stimulated by diterpenes and sesquiterpenes involved in constitutive and induced defenses J. Biol. Chem. jbc.M117.811935. doi:10.1074/jbc.M117.811935 Abstract PDF Supplemental Data Minireview - Metabolism: Kimberly A Jett and Scot C Leary Building the CuA site of cytochrome c oxidase: a complicated, redox-dependent process driven by a surprisingly large complement of accessory proteins J. Biol. Chem. jbc.R117.816132. doi:10.1074/jbc.R117.816132 Abstract PDF Plant Biology: Jian-Zhong Liu, Jicheng Duan, Min Ni, Zhen Liu, Wen-Li Qiu, Steven A. Whitham, and Wei-Jun Qian S-nitrosylation inhibits the kinase activity of tomato phosphoinositide-dependent kinase 1 (PDK1) J. Biol. Chem. jbc.M117.803882. doi:10.1074/jbc.M117.803882 Abstract PDF Signal Transduction - Protein Structure and Folding: Suhaila Rahman and Charles W. Luetje Mutant cycle analysis identifies a ligand interaction site in an odorant receptor of the malaria vector Anopheles gambiae J. Biol. Chem. jbc.M117.810374. doi:10.1074/jbc.M117.810374 Abstract PDF Supplemental Data Molecular Biophysics - Methods and Resources: Bartek Nogal, Charles A. Bowman, and Andrew B. Ward Time-course, negative−stain electron microscopy−based analysis for investigating protein−protein interactions at the single−molecule level J. Biol. Chem. jbc.M117.808352. doi:10.1074/jbc.M117.808352 Abstract PDF Supplemental Data September 28, 2017 Microbiology - Molecular Bases of Disease: Ashley C. Hoyte, Augusta V. Jamin, Pratibha C. Koneru, Matthew J. Kobe, Ross C. Larue, James R. Fuchs, Alan N. Engelman, and Mamuka Kvaratskhelia Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing J. Biol. Chem. jbc.M117.816645. doi:10.1074/jbc.M117.816645 Abstract PDF Supplemental Data Plant Biology - Metabolism: Harsh Garg, Patrick C. Loughlin, Robert D. Willows, and Min Chen The C21-formyl group in chlorophyll f originates from molecular oxygen J. Biol. Chem. jbc.M117.814756. doi:10.1074/jbc.M117.814756 Abstract PDF Cell Biology - Neurobiology: Coralie Brifault, Andrew S. Gilder, Emilia Laudati, Michael Banki, and Steven L. Gonias Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuro-inflammation J. Biol. Chem. jbc.M117.798413. doi:10.1074/jbc.M117.798413 Abstract PDF Supplemental Data Glycobiology and Extracellular Matrices - Protein Structure and Folding: Ghamdan Beshr, Asfandyar Sikandar, Eva-Maria Jemiller, Nikolai Klymiuk, Dirk Hauck, Stefanie Wagner, Eckhard Wolf, Jesko Koehnke, and Alexander Titz Photorhabdus luminescens lectin A (PllA) - a new probe for detecting α-galactoside-terminating glycoconjugates J. Biol. Chem. jbc.M117.812792. doi:10.1074/jbc.M117.812792 Abstract PDF Supplemental Data Cell Biology: Chunhe Chen, Leopold Adler IV, Patrice Goletz, Federico Gonzalez-Fernandez, Debra A. Thompson, and Yiannis Koutalos Interphotoreceptor retinoid binding protein removes all-trans retinol and retinal from rod outer segments preventing lipofuscin precursor formation J. Biol. Chem. jbc.M117.795187. doi:10.1074/jbc.M117.795187 Abstract PDF Enzymology - Protein Synthesis and Degradation: Dustin R. Todaro, Allison C. Augustus-Wallace, Jennifer M. Klein, and Arthur L. Haas The mechanism of Neural Precursor Cell Expressed Developmentally Down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly J. Biol. Chem. jbc.M117.817882. doi:10.1074/jbc.M117.817882 Abstract PDF DNA and Chromosomes - Cell Biology: Irina G. Minko, Carmelo J. Rizzo, and R. Stephen Lloyd Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: contribution of the non-canonical α-anomer J. Biol. Chem. jbc.M117.802520. doi:10.1074/jbc.M117.802520 Abstract PDF Supplemental Data September 27, 2017 Molecular Bases of Disease - Cell Biology: Victoria Stepanova, Konstantin V. Dergilev, Kelci R. Holman, Yelena V. Parfyonova, Zoya I. Tsokolaeva, Mimi Teter, Elena N. Atochina-Vasserman, Alla Volgina, Sergei V. Zaitsev, Shane P. Lewis, Fedor G. Zabozlaev, Kseniya Obraztsova, Vera P. Krymskaya, and Douglas B. Cines Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors J. Biol. Chem. jbc.M117.799593. doi:10.1074/jbc.M117.799593 Abstract PDF Enzymology - Protein Structure and Folding: Olive J. Njuma, Ian Davis, Elizabeth N. Ndontsa, Jessica R. Krewall, Aimin Liu, and Douglas C. Goodwin Mutual synergy between catalase and peroxidase activities of the bifunctional enzyme KatG is facilitated by electron-hole hopping within the enzyme J. Biol. Chem. jbc.M117.791202. doi:10.1074/jbc.M117.791202 Abstract PDF RNA - Gene Regulation: Nicola Cornella, Toma Tebaldi, Lisa Gasperini, Jarnail Singh, Richard A Padgett, Annalisa Rossi, and Paolo Macchi The hnRNP RALY regulates transcription and cell proliferation by modulating the expression of specific factors, including the proliferation-marker E2F1 J. Biol. Chem. jbc.M117.795591. doi:10.1074/jbc.M117.795591 Abstract PDF Supplemental Data Neurobiology - Cell Biology: Nicolas Arbez, Tamara Ratovitski, Elaine Roby, Ekaterine Chighladze, Jacqueline Stewart, Mark Ren, Xiaofang Wang, Daniel J Lavery, and Christopher A Ross Posttranslational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity. J. Biol. Chem. jbc.M117.782300. doi:10.1074/jbc.M117.782300 Abstract PDF Supplemental Data Gene Regulation - Signal Transduction: Jingyi Jiang, Zheng Liu, Chao Ge, Cong Chen, Fangyu Zhao, Hong Li, Taoyang Chen, Ming Yao, and Jinjun Li NK3 Homeobox 1 (NKX3.1) Upregulates Forkhead Box O1 Expression in Hepatocellular Carcinoma and Thereby Suppresses Tumor Proliferation and Invasion J. Biol. Chem. jbc.M117.793760. doi:10.1074/jbc.M117.793760 Abstract PDF Plant Biology - Protein Synthesis and Degradation: Christoph-Martin Geilfus, Raimund Tenhaken, and Sebastien Christian Carpentier Transient alkalinization of the leaf apoplast stiffens the cell wall during onset of chloride-salinity in corn leaves J. Biol. Chem. jbc.M117.799866. doi:10.1074/jbc.M117.799866 Abstract PDF Supplemental Data Plant Biology - Bioenergetics: Eunchul Kim, Seiji Akimoto, Ryutaro Tokutsu, Makio Yokono, and Jun Minagawa Fluorescence lifetime analyses reveal how the high light-responsive protein LHCSR3 transforms PSII light-harvesting complexes into an energy-dissipative state J. Biol. Chem. jbc.M117.805192. doi:10.1074/jbc.M117.805192 Abstract PDF Supplemental Data Membrane Biology - Molecular Biophysics: H Sasimali M Soysa, Albert Schulte, and Wipa Suginta Functional analysis of an unusual porin-like channel that imports chitin for alternative carbon metabolism in Escherichia coli J. Biol. Chem. jbc.M117.812321. doi:10.1074/jbc.M117.812321 Abstract PDF Microbiology - Protein Structure and Folding: Lindsey S Marmont, Gregory B Whitfield, Jacquelyn D Rich, Patrick Yip, Laura B Giesbrecht, Carol A Stremick, John C Whitney, Matthew R Parsek, Joe J Harrison, and P. Lynne Howell PelA and PelB form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation in Pseudomonas aeruginosa J. Biol. Chem. jbc.M117.812842. doi:10.1074/jbc.M117.812842 Abstract PDF Supplemental Data Enzymology: Paul W Heron and Jurgen Sygusch Isomer Activation Controls Stereospecificity of Class I Fructose-1,6-bisphosphate Aldolases J. Biol. Chem. jbc.M117.811034. doi:10.1074/jbc.M117.811034 Abstract PDF Supplemental Data Signal Transduction - Cell Biology: Yoshihiro Hasegawa, Motoko Takahashi, Shigeru Ariki, Atsushi Saito, Yasuaki Uehara, Rina Takamiya, Koji Kuronuma, Hirofumi Chiba, Yuji Sakuma, Hiroki Takahashi, and Yoshio Kuroki Surfactant protein A downregulates epidermal growth factor receptor by mechanisms different from those of surfactant protein D J. Biol. Chem. jbc.M117.800771. doi:10.1074/jbc.M117.800771 Abstract PDF Cell Biology - Signal Transduction: Wei-Chih Tsai, Lucas C Reineke, Antrix Jain, Sung Yun Jung, and Richard E Lloyd Histone arginine demethylase JMJD6 is linked to stress granule assembly through demethylation of the stress granule nucleating protein G3BP1 J. Biol. Chem. jbc.M117.800706. doi:10.1074/jbc.M117.800706 Abstract PDF Lipids - Membrane Biology: Akira Murakami, Kohjiro Nagao, Naoto Juni, Yuji Hara, and Masato Umeda An N-terminal di-proline motif is essential for fatty acid-dependent degradation of Δ9-desaturase in Drosophila J. Biol. Chem. jbc.M117.801936. doi:10.1074/jbc.M117.801936 Abstract PDF Supplemental Data Lipids: Ngee Kiat Chua, Vicky Howe, Nidhi Jatana, Lipi Thukral, and Andrew J. Brown A Conserved Degron Containing an Amphipathic Helix Regulates the Cholesterol-Mediated Turnover of Human Squalene Monooxygenase, a Rate-Limiting Enzyme in Cholesterol Synthesis J. Biol. Chem. jbc.M117.794230. doi:10.1074/jbc.M117.794230 Abstract PDF September 26, 2017 DNA and Chromosomes - Enzymology: Yan Su, Martin Egli, and F. Peter Guengerich Human DNA polymerase η accommodates RNA for strand extension J. Biol. Chem. jbc.M117.809723. doi:10.1074/jbc.M117.809723 Abstract PDF Supplemental Data Cell Biology - Protein Synthesis and Degradation: Monica Boselli, Byung-Hoon Lee, Jessica Robert, Miguel A Prado, Sang-won Min, Chialin Cheng, M Catarina Silva, Changhyun Seong, Suzanne Elsasser, Ketki M Hatle, Timothy C. Gahman, Steven P. Gygi, Stephen J. Haggarty, Li Gan, Randall W. King, and Daniel Finley An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons J. Biol. Chem. jbc.M117.815126. doi:10.1074/jbc.M117.815126 Abstract PDF Supplemental Data Microbiology: Herman Tse, Dan Yang, Kong-Hung Sze, Ivan K. Chu, Richard Y. T. Kao, Kam-Chung Lee, Ching-Wan Lam, Qiangshuai Gu, Sherlock Shing-Chiu Tai, Yihong Ke, Elaine Chan, Wan-Mui Chan, Jun Dai, Sze-Pui Leung, Suet-Yi Leung, and Kwok-Yung Yuen A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis J. Biol. Chem. jbc.M117.791558. doi:10.1074/jbc.M117.791558 Abstract PDF Supplemental Data DNA and Chromosomes - Gene Regulation: Hussain Zaidi, Elizabeth A. Hoffman, Savera J. Shetty, Stefan Bekiranov, and David T. Auble Second-generation method for analysis of chromatin binding with formaldehyde crosslinking kinetics J. Biol. Chem. jbc.M117.796441. doi:10.1074/jbc.M117.796441 Abstract PDF Supplemental Data Cell Biology - Gene Regulation: Hongchao Cao, Shengjie Zhang, Shifang Shan, Chao Sun, Yan Li, Hui Wang, Shuxian Yu, Yi Liu, Feifan Guo, Qiwei Zhai, Yu-cheng Wang, Jingjing Jiang, Hui Wang, Jun Yan, Wei Liu, and Hao Ying Ligand-dependent corepressor (LCoR) represses the transcription factor C/EBPβ during early adipocyte differentiation J. Biol. Chem. jbc.M117.793984. doi:10.1074/jbc.M117.793984 Abstract PDF Supplemental Data Cell Biology - Molecular Biophysics: Raul E Guzman, Stefanie Bungert-Plümke, Arne Franzen, and Christoph Fahlke Preferential Association with ClC-3 Permits Sorting of ClC-4 into Endosomal Compartments J. Biol. Chem. jbc.M117.801951. doi:10.1074/jbc.M117.801951 Abstract PDF Cell Biology - Developmental Biology: Yuanyuan Li, Ran Wang, Nan Qiao, Guangdun Peng, Ke Zhang, Ke Tang, Jing-dong J Han, and Naihe Jing Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells J. Biol. Chem. jbc.M117.796383. doi:10.1074/jbc.M117.796383 Abstract PDF Supplemental Data Neurobiology - Cell Biology: Thang Luong Pham, Jiucheng He, Azucena Kakazu, Bokkyoo Jun, Nicolas G. Bazan, and Haydee E. P. Bazan Defining a mechanistic link between pigment epithelium-derived factor, docosahexaenoic acid and corneal nerve regeneration J. Biol. Chem. jbc.M117.801472. doi:10.1074/jbc.M117.801472 Abstract PDF Supplemental Data September 25, 2017 Molecular Bases of Disease - Molecular Biophysics: Cameron J. Powell, Meredith L. Jenkins, Michelle L. Parker, Raghavendran Ramaswamy, Anne Kelsen, David M. Warshaw, Gary E. Ward, John E. Burke, and Martin J. Boulanger Dissecting the molecular assembly of the Toxoplasma gondii MyoA motility complex J. Biol. Chem. jbc.M117.809632. doi:10.1074/jbc.M117.809632 Abstract PDF Supplemental Data Immunology: Lucy C. Sullivan, Nicholas G. Walpole, Carine Farenc, Gabriella Pietra, Matthew J. Wenhwa Sum, Craig S. Clements, Eleanor J. Lee, Travis Beddoe, Michela Falco, Maria Cristina Mingari, Lorenzo Moretta, Stephanie Gras, Jamie Rossjohn, and Andrew G. Brooks A conserved energetic footprint underpins recognition of Human Leukocyte Antigen-E by two distinct αβ T cell receptors J. Biol. Chem. jbc.M117.807719. doi:10.1074/jbc.M117.807719 Abstract PDF Molecular Bases of Disease - Cell Biology: Stephen R Thom, Veena M Bhopale, Kevin Yu, Weiliang Huang, Maureen A Kane, and David J Margolis Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability J. Biol. Chem. jbc.M117.802629. doi:10.1074/jbc.M117.802629 Abstract PDF Microbiology - Immunology: Jiyeun Kate Kim, Ho Am Jang, Min Seon Kim, Jae Hyun Cho, Jum Beom Lee, Flaviana Di Lorenzo, Luisa Sturiale, Alba Silipo, Antonio Molinaro, and Bok Luel Lee The lipopolysaccharide core oligosaccharide of Burkholderia plays a critical role in maintaining a proper gut symbiosis with the bean bug Riptortus pedestris J. Biol. Chem. jbc.M117.813832. doi:10.1074/jbc.M117.813832 Abstract PDF Metabolism - Computational Biology: Cecilia Brännmark, William Lövfors, Ali M. Komai, Tom Axelsson, Mickaël F. El Hachmane, Saliha Musovic, Alexandra Paul, Elin Nyman, and Charlotta S. Olofsson Mathematical modeling of white adipocyte exocytosis predicts adiponectin secretion and quantifies the rate of vesicle exo- and endocytosis. J. Biol. Chem. jbc.M117.801225. doi:10.1074/jbc.M117.801225 Abstract PDF Minireview - DNA and Chromosomes: Stephen J Benkovic and Michelle M Spiering Understanding DNA replication by the bacteriophage T4 replisome J. Biol. Chem. jbc.R117.811208. doi:10.1074/jbc.R117.811208 Abstract PDF Protein Structure and Folding - Molecular Bases of Disease: Ryan P. Emptage, Megan J. Schoenberger, Kathryn M. Ferguson, and Ronen Marmorstein Intramolecular autoinhibition of Checkpoint Kinase 1 is mediated by conserved basic motifs of the C-terminal Kinase Associated-1 domain J. Biol. Chem. jbc.M117.811265. doi:10.1074/jbc.M117.811265 Abstract PDF Microbiology - Gene Regulation: Jingjing Xu, Jihui Zhang, Jiming Zhuo, Yue Li, Yuqing Tian, and Huarong Tan Activation and molecular mechanism of a cryptic oviedomycin biosynthetic gene cluster via the disruption of a global regulatory gene--adpA in Streptomyces ansochromogenes J. Biol. Chem. jbc.M117.809145. doi:10.1074/jbc.M117.809145 Abstract PDF Supplemental Data Neurobiology - Molecular Biophysics: Jean Chemin, Valentina Taiakina, Arnaud Monteil, Michael Piazza, Wendy Guan, Robert F. Stephens, Ashraf Kitmitto, Zhiping P. Pang, Annette C. Dolphin, Edward Perez-Reyes, Thorsten Dieckmann, Joseph Guy Guillemette, and J David Spafford Calmodulin regulates Cav3 T-type channels at their gating brake J. Biol. Chem. jbc.M117.807925. doi:10.1074/jbc.M117.807925 Abstract PDF Molecular Bases of Disease - Signal Transduction: Ragadeepthi Tunduguru, Jing Zhang, Arianne Aslamy, Vishal A. Salunkhe, Joseph T. Brozinick, Jeffrey S. Elmendorf, and Debbie C. Thurmond The actin-related p41ARC subunit contributes to p21-activated kinase-1 (PAK1)-mediated glucose uptake into skeletal muscle cells J. Biol. Chem. jbc.M117.801340. doi:10.1074/jbc.M117.801340 Abstract PDF Supplemental Data September 22, 2017 RNA - Cell Biology: Daniel Shedlovskiy, Jessica A. Zinskie, Ethan Gardner, Dimitri G. Pestov, and Natalia Shcherbik Endonucleolytic cleavage in the expansion segment 7 of 25S rRNA is an early marker of low-level oxidative stress in yeast. J. Biol. Chem. jbc.M117.800003. doi:10.1074/jbc.M117.800003 Abstract PDF Cell Biology - Signal Transduction: Gergö Gulyás, Glória Radvánszki, Rita Matuska, András Balla, László Hunyady, Tamas Balla, and Péter Várnai Plasma membrane phosphatidylinositol 4-phosphate and 4,5-bisphosphate determine the distribution and function of K-Ras4B but not H-Ras proteins J. Biol. Chem. jbc.M117.806679. doi:10.1074/jbc.M117.806679 Abstract PDF Supplemental Data Membrane Biology - Cell Biology: Motoki Inoshita and Joji Mima Human Rab small GTPase- and class V myosin-mediated membrane tethering in a chemically defined reconstitution system J. Biol. Chem. jbc.M117.811356. doi:10.1074/jbc.M117.811356 Abstract PDF Supplemental Data Signal Transduction - Molecular Bases of Disease: Sungjin Kim, Xiangkun Yang, Qianjin Li, Meng Wu, Leah Costyn, Zanna Beharry, Michael G Bartlett, and Houjian Cai Myristoylation of Src kinase mediates Src induced and high fat diet accelerated prostate tumor progression in mice J. Biol. Chem. jbc.M117.798827. doi:10.1074/jbc.M117.798827 Abstract PDF Supplemental Data Molecular Biophysics - Enzymology: W. Austin Elam, Wenxiang Cao, Hyeran Kang, Andrew Huehn, Glen M Hocky, Ewa Prochniewicz, Anthony C Schramm, Karina Negrón, Jean Garcia, Teresa T Bonello, Peter W Gunning, David D Thomas, Greg A Voth, Charles V Sindelar, and Enrique M De La Cruz Phosphomimetic S3D-Cofilin Binds But Only Weakly Severs Actin Filaments J. Biol. Chem. jbc.M117.808378. doi:10.1074/jbc.M117.808378 Abstract PDF Supplemental Data DNA and Chromosomes - Molecular Biophysics: Sean M. Carney, Shivasankari Gomathinayagam, Sanford H. Leuba, and Michael A. Trakselis Bacterial DnaB helicase interacts with the excluded strand to regulate unwinding J. Biol. Chem. jbc.M117.814178. doi:10.1074/jbc.M117.814178 Abstract PDF Supplemental Data DNA and Chromosomes: Jung-Hoon Yoon, Jayati Roy Choudhury, Jeseong Park, Satya Prakash, and Louise Prakash Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyl adenine J. Biol. Chem. jbc.M117.808659. doi:10.1074/jbc.M117.808659 Abstract PDF Molecular Bases of Disease - Protein Structure and Folding: Maya V. Rao, Dewight R. Williams, Simon Cocklin, and Patrick J. Loll Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding J. Biol. Chem. jbc.M117.806281. doi:10.1074/jbc.M117.806281 Abstract PDF Supplemental Data Cell Biology - Protein Structure and Folding: Di Shen, Nataly P. Podolnikova, Valentin P. Yakubenko, Christopher L. Ardell, Arnat Balabiyev, Tatiana P. Ugarova, and Xu Wang PLEIOTROPHIN, A MULTIFUNCTIONAL CYTOKINE AND GROWTH FACTOR, INDUCES LEUKOCYTE RESPONSES THROUGH THE INTEGRIN MAC-1 J. Biol. Chem. jbc.M116.773713. doi:10.1074/jbc.M116.773713 Abstract PDF Supplemental Data Membrane Biology - Neurobiology: Sathya Challasivakanaka, Juan Zhen, Margaret E. Smith, Maarten E. A. Reith, James D. Foster, and Roxanne A. Vaughan Dopamine Transporter Phosphorylation Site Threonine 53 is Stimulated by Amphetamines and Regulates Dopamine Transport, Efflux, and Cocaine Analog Binding J. Biol. Chem. jbc.M117.787002. doi:10.1074/jbc.M117.787002 Abstract PDF Signal Transduction: Barbara Taskinen, Evandro Ferrada, and Douglas M Fowler Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase J. Biol. Chem. jbc.M117.811174. doi:10.1074/jbc.M117.811174 Abstract PDF Supplemental Data Cell Biology - Signal Transduction: Shin-ichi Oka, Tsuyoshi Hirata, Wataru Suzuki, Daichi Naito, Yanbin Chen, Adave Chin, Hiroaki Yaginuma, Toshiro Saito, Narayani Nagarajan, Peiyong Zhai, Santosh Bhat, Kevin Schesing, Dan Shao, Yoko Hirabayashi, Junji Yodoi, Sebastiano Sciarretta, and Junichi Sadoshima Thioredoxin-1 maintains mTOR function during oxidative stress in cardiomyocytes J. Biol. Chem. jbc.M117.807735. doi:10.1074/jbc.M117.807735 Abstract PDF Gene Regulation - DNA and Chromosomes: Teresita Padilla-Benavides, Brian T. Nasipak, Amanda L. Paskavitz, Dominic T. Haokip, Jake M. Schnabl, Jeffrey A. Nickerson, and Anthony N. Imbalzano Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition J. Biol. Chem. jbc.M117.799676. doi:10.1074/jbc.M117.799676 Abstract PDF September 21, 2017 Cell Biology - Developmental Biology: Shangtao Cao, Shengyong Yu, Yan Chen, Xiaoshang Wang, Chunhua Zhou, Yuting Liu, Junqi Kuang, He Liu, Dongwei Li, Jing Ye, Yue Qing, Shilong Chu, Linlin Wu, Lin Guo, Yinxiong Li, Xiaodong Shu, Jiekai Chen, Jing Liu, and Duanqing Pei Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage J. Biol. Chem. jbc.M117.812537. doi:10.1074/jbc.M117.812537 Abstract PDF Supplemental Data Protein Structure and Folding - Gene Regulation: Maria Carmen Mulero, De-Bin Huang, H Thien Nguyen, Vivien Wang, Yidan Li, Tapan Biswas, and Gourisankar Ghosh DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor kappa B are not correlated J. Biol. Chem. jbc.M117.813980. doi:10.1074/jbc.M117.813980 Abstract PDF September 20, 2017 Enzymology - Microbiology: Eugene Kuatsjah, Anson C. K. Chan, Marek J. Kobylarz, Michael E. P. Murphy, and Lindsay D. Eltis The bacterial meta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the α/β-hydrolase superfamily J. Biol. Chem. jbc.M117.797696. doi:10.1074/jbc.M117.797696 Abstract PDF Supplemental Data Protein Structure and Folding - Molecular Biophysics: Naoya Shibayama, Mio Ohki, Jeremy RH Tame, and Sam-Yong Park Direct observation of conformational population shifts in crystalline human hemoglobin J. Biol. Chem. jbc.M117.781146. doi:10.1074/jbc.M117.781146 Abstract PDF Lipids - Gene Regulation: Maria L. Gaspar, Yu-Fang Chang, Stephen A. Jesch, Manuel Aregullin, and Susan A. Henry Interaction between repressor Opi1p and ER membrane protein Scs2p facilitates transit of phosphatidic acid from the ER to mitochondria and is essential for INO1 gene expression in the presence of choline J. Biol. Chem. jbc.M117.809970. doi:10.1074/jbc.M117.809970 Abstract PDF Molecular Bases of Disease - Neurobiology: Timothy D. Kurt, Patricia Aguilar-Calvo, Lin Jiang, José A. Rodriguez, Nazilla Alderson, David S. Eisenberg, and Christina J. Sigurdson Asparagine and glutamine ladders promote cross-species prion conversion J. Biol. Chem. jbc.M117.794107. doi:10.1074/jbc.M117.794107 Abstract PDF Supplemental Data Immunology - Protein Structure and Folding: Xinbo Yang, Guobing Chen, Nan-ping Weng, and Roy A. Mariuzza Structural basis for clonal diversity of the human T cell response to a dominant influenza virus epitope J. Biol. Chem. jbc.M117.810382. doi:10.1074/jbc.M117.810382 Abstract PDF September 19, 2017 Glycobiology and Extracellular Matrices - Microbiology: Anders A. J. Jinnelov, Liaqat Ali, Michele Tinti, and Michael A. J. Ferguson Single-subunit oligosaccharyltransferases of Trypanosoma brucei display different and predictable peptide acceptor specificities. J. Biol. Chem. jbc.M117.810945. doi:10.1074/jbc.M117.810945 Abstract PDF Supplemental Data Immunology: Johnny Nakhleh, George K Christophides, and Mike A Osta The serine protease homolog CLIPA14 modulates the intensity of the immune response in the mosquito Anopheles gambiae J. Biol. Chem. jbc.M117.797787. doi:10.1074/jbc.M117.797787 Abstract PDF Supplemental Data Glycobiology and Extracellular Matrices - Molecular Biophysics: M. Osman Sheikh, David Thieker, Gordon Chalmers, Christopher M. Schafer, Mayumi Ishihara, Parastoo Azadi, Robert J. Woods, John N. Glushka, Brad Bendiak, James H. Prestegard, and Christopher M. West O2 sensing associated glycosylation exposes the F-box combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases J. Biol. Chem. jbc.M117.809160. doi:10.1074/jbc.M117.809160 Abstract PDF Supplemental Data Glycobiology and Extracellular Matrices - Microbiology: Kazi Rahman, Msano Mandalasi, Peng Zhao, M. Osman Sheikh, Rahil Taujale, Hyun W. Kim, Hanke van der Wel, Khushi Matta, Natarajan Kannan, John N. Glushka, Lance Wells, and Christopher M. West Characterization of a cytoplasmic glucosyltransferase that extends the core trisaccharide of the Toxoplasma Skp1 E3 ubiquitin ligase subunit J. Biol. Chem. jbc.M117.809301. doi:10.1074/jbc.M117.809301 Abstract PDF Supplemental Data Molecular Bases of Disease - Neurobiology: Zhan-ying Hu, Bo Chen, Jing-pu Zhang, and Yuan-yuan Ma Upregulation of autophagy-related gene 5 protects dopaminergic neurons in a zebrafish model of Parkinson's disease J. Biol. Chem. jbc.M116.764795. doi:10.1074/jbc.M116.764795 Abstract PDF Supplemental Data Cell Biology - Methods and Resources: Saliha Majdoul, Jérémie Cosette, Ababacar K. Seye, Eric Bernard, Sophie Frin, Nathalie Holic, Nathalie Chazal, Laurence Briant, Lucile Espert, Anne Galy, and David Fenard Peptides derived from evolutionarily conserved domains in Beclin1 and Beclin2 enhance the entry of lentiviral vectors into human cells J. Biol. Chem. jbc.M117.800813. doi:10.1074/jbc.M117.800813 Abstract PDF Supplemental Data September 18, 2017 Enzymology - Protein Synthesis and Degradation: Virginia P. Ronchi, Elizabeth D. Kim, Christopher M. Summa, Jennifer M. Klein, and Arthur L. Haas In silico modeling of the cryptic E2~ubiquitin binding site of E6-associated Protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly J. Biol. Chem. jbc.M117.813477. doi:10.1074/jbc.M117.813477 Abstract PDF Supplemental Data Metabolism - Cell Biology: Ting Zhao, Xinchun Ding, Cong Yan, and Hong Du Endothelial Rab7 GTPase Mediates Tumor Growth and Metastasis in Lysosomal Acid Lipase Deficient Mice J. Biol. Chem. jbc.M116.773093. doi:10.1074/jbc.M116.773093 Abstract PDF Supplemental Data Signal Transduction - Immunology: Leah Cushing, Aaron Winkler, Scott A Jelinsky, Katherine Lee, Wouter Korver, Rachael Hawtin, Vikram R Rao, Margaret Fleming, and Lih-Ling Lin IRAK4 kinase activity controls Toll-like receptor induced inflammation through the transcription factor IRF5 in primary human monocytes J. Biol. Chem. jbc.M117.796912. doi:10.1074/jbc.M117.796912 Abstract PDF Supplemental Data Signal Transduction - Developmental Biology: Edward N Anderson and Kristi A Wharton Alternative cleavage of the bone morphogenetic protein (BMP), Gbb, produces ligands with distinct developmental functions and receptor preference J. Biol. Chem. jbc.M117.793513. doi:10.1074/jbc.M117.793513 Abstract PDF Supplemental Data Cell Biology - Signal Transduction: Hannah E. Opalko and James B. Moseley Dynamic regulation of Cdr1 localization and phosphorylation during osmotic stress J. Biol. Chem. jbc.M117.793034. doi:10.1074/jbc.M117.793034 Abstract PDF Supplemental Data Cell Biology: Ahmed Waraky, Yingbo Lin, Dudi Warsito, Felix Haglund, Eiman Aleem, and Olle Larsson Sr. Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage J. Biol. Chem. jbc.M117.781492. doi:10.1074/jbc.M117.781492 Abstract PDF Supplemental Data Molecular Biophysics - Computational Biology: Narendar Kolimi, Yogeeshwar Ajjugal, and Thenmalarchelvi Rathinavelan A B−−Z junction induced by an A...A mismatch in GAC repeats in the gene for cartilage oligomeric matrix protein promotes binding with the hZαADAR1 protein J. Biol. Chem. jbc.M117.796235. doi:10.1074/jbc.M117.796235 Abstract PDF Supplemental Data Protein Structure and Folding - Computational Biology: Jun Zhao, Ruth Nussinov, and Buyong Ma Mechanisms of recognition of Aβ monomer, oligomer, and fibril by homologous antibodies J. Biol. Chem. jbc.M117.801514. doi:10.1074/jbc.M117.801514 Abstract PDF Supplemental Data Molecular Biophysics - Cell Biology: Yuan Lin, Simon L Currie, and Michael Keith Rosen Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs J. Biol. Chem. jbc.M117.800466. doi:10.1074/jbc.M117.800466 Abstract PDF Supplemental Data Molecular Bases of Disease - Metabolism: Mastura Wahedi, Aaron W. Wortham, Mark D. Kleven, Ningning Zhao, Shall Jue, Caroline A. Enns, and An-Sheng Zhang Matriptase-2 Suppresses Hepcidin Expression by Cleaving Multiple Components of the Hepcidin Induction Pathway J. Biol. Chem. jbc.M117.801795. doi:10.1074/jbc.M117.801795 Abstract PDF Supplemental Data DNA and Chromosomes - Cell Biology: Songwei He, Hao Sun, Lilong Lin, Yixin Zhang, Jinlong Chen, Lining Liang, Yuan Li, Mengdan Zhang, Xiao Yang, Xiaoshan Wang, Fuhui Wang, Feiyan Zhu, Jiekai Chen, Duanqing Pei, and Hui Zheng Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells J. Biol. Chem. jbc.M117.810457. doi:10.1074/jbc.M117.810457 Abstract PDF Supplemental Data Protein Structure and Folding - Neurobiology: Yijia Xu, Xiangxue Meng, Xue Hou, Jianfang Sun, Xiaohua Kong, Yuqi Sun, Zeyu Liu, Yuanyuan Ma, Ye Niu, Yongbo Song, Yong Cui, Mingyi Zhao, and Jinghai Zhang A mutant of the BmK antitumor-analgesic peptide exhibits reduced inhibition to hNav1.4 and hNav1.5 channels while retaining analgesic activity J. Biol. Chem. jbc.M117.792697. doi:10.1074/jbc.M117.792697 Abstract PDF Supplemental Data Molecular Bases of Disease - Molecular Biophysics: Gianluca Interlandi, Olga Yakovenko, An-Yue Tu, Jeff Harris, Jennie Le, Junmei Chen, José A López, and Wendy E Thomas Specific electrostatic interactions between charged amino acid residues regulate binding of von Willebrand factor to blood platelets J. Biol. Chem. jbc.M117.797456. doi:10.1074/jbc.M117.797456 Abstract PDF Supplemental Data Neurobiology - Protein Synthesis and Degradation: Guo Zhang, Ferdinand S Vilim, Dan-Dan Liu, Elena V Romanova, Ke Yu, Wang-Ding Yuan, Hui Xiao, Amanda B Hummon, Ting-Ting Chen, Vera Alexeeva, Si-Yuan Yin, Song-An Chen, Elizabeth C Cropper, Jonathan V Sweedler, Klaudiusz R Weiss, and Jian Jing Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model, Aplysia J. Biol. Chem. jbc.M117.795450. doi:10.1074/jbc.M117.795450 Abstract PDF Supplemental Data Lipids - Gene Regulation: Praveen Kumar Rajvanshi, Madhuri Arya, and Ram Rajasekharan The stress-regulatory transcription factors Msn2 and Msn4 regulate fatty acid oxidation in budding yeast J. Biol. Chem. jbc.M117.801704. doi:10.1074/jbc.M117.801704 Abstract PDF Signal Transduction - Molecular Biophysics: Tong Lu, Xiao-Li Wang, Qiang Chai, Xiaojing Sun, Gary C. Sieck, Zvonimir S. Katusic, and Hon-Chi Lee Role of the Endothelial Caveolae Microdomain in Shear Stress-Mediated Coronary Vasorelaxation J. Biol. Chem. jbc.M117.786152. doi:10.1074/jbc.M117.786152 Abstract PDF September 16, 2017 Protein Structure and Folding - Protein Synthesis and Degradation: Michiel J.M. Niesen, Stephen S. Marshall, Thomas F. Miller III, and William M. Clemons Jr. Improving membrane protein expression by optimizing integration efficiency J. Biol. Chem. jbc.M117.813469. doi:10.1074/jbc.M117.813469 Abstract PDF Supplemental Data September 15, 2017 Membrane Biology - Molecular Bases of Disease: Jonathan Bruno, Nicola Pozzi, Jonathan Oliva, and John C. Edwards Apolipoprotein L1 confers pH-switchable ion permeability to phospholipid vesicles J. Biol. Chem. jbc.M117.813444. doi:10.1074/jbc.M117.813444 Abstract PDF Neurobiology - Signal Transduction: Xiaohan Wang, Christian R Marks, Tyler L Perfitt, Terunaga Nakagawa, Amy Lee, David A Jacobson, and Roger J Colbran A novel mechanism for Ca2+/calmodulin-dependent protein kinase II targeting to L-type Ca2+ channels that initiates long-range signaling to the nucleus J. Biol. Chem. jbc.M117.788331. doi:10.1074/jbc.M117.788331 Abstract PDF Gene Regulation - Developmental Biology: Rachel Herndon Klein, William Hu, Ghaidaa Kashgari, Ziguang Lin, Tuyen Nguyen, Michael Doan, and Bogi Andersen Characterization of enhancers and the role of the transcription factor KLF7 in regulating corneal epithelial differentiation J. Biol. Chem. jbc.M117.793117. doi:10.1074/jbc.M117.793117 Abstract PDF Supplemental Data Molecular Bases of Disease - Signal Transduction: Misako Sato-Matsubara, Tsutomu Matsubara, Atsuko Daikoku, Yoshinori Okina, Lisa Longato, Krista Rombouts, Le Thi Thanh Thuy, Jun Adachi, Takeshi Tomonaga, Kazuo Ikeda, Katsutoshi Yoshizato, Massimo Pinzani, and Norifumi Kawada Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling J. Biol. Chem. jbc.M117.793794. doi:10.1074/jbc.M117.793794 Abstract PDF Supplemental Data Immunology - Molecular Bases of Disease: Risa Ebina-Shibuya, Mitsuyo Matsumoto, Makoto Kuwahara, Kyoung-Jin Jang, Manabu Sugai, Yoshiaki Ito, Ryo Funayama, Keiko Nakayama, Yuki Sato, Naoto Ishii, Yasunobu Okamura, Kengo Kinoshita, Kohei Kometani, Tomohiro Kurosaki, Akihiko Muto, Masakazu Ichinose, Masakatsu Yamashita, and Kazuhiko Igarashi Inflammatory responses induce an identity crisis of alveolar macrophages leading to pulmonary alveolar proteinosis. J. Biol. Chem. jbc.M117.808535. doi:10.1074/jbc.M117.808535 Abstract PDF Supplemental Data Metabolism - Methods and Resources: Molly A. Silvers, Stanislaw Deja, Naveen Singh, Robert A. Egnatchik, Jessica Sudderth, Xiuquan Luo, Muhammad S. Beg, Shawn C. Burgess, Ralph J. DeBerardinis, David A. Boothman, and Matthew E. Merritt The NQO1 bioactivatable drug, β-Lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism J. Biol. Chem. jbc.M117.813923. doi:10.1074/jbc.M117.813923 Abstract PDF Supplemental Data Metabolism - Cell Biology: Robert M. Jackson, Beth A. Griesel, Jami M. Gurley, Luke I. Szweda, and Ann Louise Olson Glucose availability controls adipogenesis in mouse 3T3-L1 adipocytes via upregulation of nicotinamide metabolism J. Biol. Chem. jbc.M117.791970. doi:10.1074/jbc.M117.791970 Abstract PDF Lipids - Metabolism: Andrea S. Pereyra, Like Y. Hasek, Kate L. Harris, Alycia G. Berman, Frederick W. Damen, Craig J. Goergen, and Jessica M. Ellis Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy J. Biol. Chem. jbc.M117.800839. doi:10.1074/jbc.M117.800839 Abstract PDF Supplemental Data Genomics and Proteomics - Signal Transduction: Mansi Y. Shinde, Simone Sidoli, Katarzyna Kulej, Michael J. Mallory, Caleb M. Radens, Amanda Reicherter, Rebecca L. Myers, Yoseph Barash, Kristen W. Lynch, Benjamin A. Garcia, and Peter S. Klein Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing J. Biol. Chem. jbc.M117.813527. doi:10.1074/jbc.M117.813527 Abstract PDF Supplemental Data September 14, 2017 Developmental Biology - Cell Biology: Bill X. Wu, Anqi Li, Liming Lei, Satoshi Kaneko, Caroline Wallace, Xue Li, and Zihai Li Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis J. Biol. Chem. jbc.M117.797613. doi:10.1074/jbc.M117.797613 Abstract PDF Supplemental Data Protein Synthesis and Degradation - Genomics and Proteomics: Jonas Sieber, Nicolas Wieder, Mauricio Ostrosky-Frid, Moran Dvela-Levitt, Ozan Aygün, Namrata D Udeshi, Steven A Carr, and Anna Greka Lysine trimethylation regulates 78 kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress J. Biol. Chem. jbc.M117.797084. doi:10.1074/jbc.M117.797084 Abstract PDF Supplemental Data Immunology: Thomas B. Huffaker, Soh-Hyun Lee, William W. Tang, Jared A. Wallace, Margaret Alexander, Marah C. Runtsch, Dane K. Larsen, Jacob Thompson, Andrew G. Ramstead, Warren P. Voth, Ruozhen Hu, June L. Round, Matthew A. Williams, and Ryan M. O'Connell Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade J. Biol. Chem. jbc.M117.808121. doi:10.1074/jbc.M117.808121 Abstract PDF Supplemental Data Glycobiology and Extracellular Matrices - Microbiology: Yang Shen, Samy Boulos, Eric Sumrall, Benjamin Gerber, Alicia Julian-Rodero, Marcel R. Eugster, Lars Fieseler, Laura Nyström, Marc-Olivier Ebert, and Martin J Loessner Structural and functional diversity in Listeria cell wall teichoic acids J. Biol. Chem. jbc.M117.813964. doi:10.1074/jbc.M117.813964 Abstract PDF Supplemental Data Molecular Bases of Disease - Molecular Biophysics: Luiza M. Bessa, Hélène Launay, Marie Dujardin, François-Xavier Cantrelle, Guy Lippens, Isabelle Landrieu, Robert Schneider, and Xavier Hanoulle NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B J. Biol. Chem. jbc.M117.813766. doi:10.1074/jbc.M117.813766 Abstract PDF Supplemental Data Minireview - Gene Regulation - Protein Structure and Folding: Thomas M. Harper and Dylan J. Taatjes The complex structure and function of Mediator J. Biol. Chem. jbc.R117.794438. doi:10.1074/jbc.R117.794438 Abstract PDF Cell Biology - Signal Transduction: Makiko Tsuboi, Keisuke Taniuchi, Takahiro Shimizu, Motoaki Saito, and Toshiji Saibara The Transcription Factor HOXB7 Regulates ERK Kinase Activity and Thereby Stimulates the Motility and Invasiveness of Pancreatic Cancer Cells J. Biol. Chem. jbc.M116.772780. doi:10.1074/jbc.M116.772780 Abstract PDF Supplemental Data Developmental Biology - Neurobiology: Xinwang Zhang, Menglong Rui, Guangmin Gan, Cong Huang, Jukang Yi, Huihui Lv, and Wei Xie Neuroligin 4 Regulates Synaptic Growth via the Bone Morphogenetic Protein (BMP) Signaling Pathway at the Drosophila Neuromuscular Junction J. Biol. Chem. jbc.M117.810242. doi:10.1074/jbc.M117.810242 Abstract PDF Supplemental Data Minireview - Gene Regulation - Protein Structure and Folding: Lindsay E. Moritz and Raymond C. Trievel Structure, mechanism, and regulation of polycomb repressive complex 2 J. Biol. Chem. jbc.R117.800367. doi:10.1074/jbc.R117.800367 Abstract PDF Enzymology - Microbiology: Michael T. Ringel, Gerald Draeger, and Thomas Brueser The periplasmic transaminase PtaA of Pseudomonas fluorescens converts the glutamic acid residue at the pyoverdine fluorophore to α-ketoglutaric acid J. Biol. Chem. jbc.M117.812545. doi:10.1074/jbc.M117.812545 Abstract PDF Supplemental Data Cell Biology - Signal Transduction: Gandhi T. K. Boopathy, Madhura Kulkarni, Sze Yuan Ho, Adrian Boey, Edmond Wei Min Chua, Veluchamy A Barathi, Tom J Carney, Xiaomeng Wang, and Wanjin Hong Cavin-2 regulates the activity and stability of endothelial nitric oxide synthase (eNOS) in angiogenesis J. Biol. Chem. jbc.M117.794743. doi:10.1074/jbc.M117.794743 Abstract PDF Supplemental Data September 13, 2017 Protein Structure and Folding - Molecular Biophysics: Natalie Woolger, Adam Bournazos, Reece A Sophocleous, Frances J Evesson, Angela Lek, Birgit Driemer, R Bryan Sutton, and Sandra T Cooper Limited proteolysis as a tool to probe the tertiary conformation of dysferlin and structural consequences of patient missense variant L344P J. Biol. Chem. jbc.M117.790014. doi:10.1074/jbc.M117.790014 Abstract PDF Supplemental Data Protein Structure and Folding - Gene Regulation: Shunya Sakurai, Toshiyuki Shimizu, and Umeharu Ohto The crystal structure of the AhRR/ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription J. Biol. Chem. jbc.M117.812974. doi:10.1074/jbc.M117.812974 Abstract PDF RNA - Cell Biology: James T. DeLigio, Grace Lin, Charles E. Chalfant, and Margaret A. Park Splice variants of cytosolic polyadenylation element binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis J. Biol. Chem. jbc.M117.810127. doi:10.1074/jbc.M117.810127 Abstract PDF Cell Biology - Signal Transduction: Gui-Ru Wu, Tian-Chen Mu, Zhen-Xing Gao, Jun Wang, Man-Sun Sy, and Chao-yang Li Prion protein is required for tumor necrosis factor alpha (TNFα)-triggered nuclear factor kappa B (NF-κB) signaling and cytokine production J. Biol. Chem. jbc.M117.787283. doi:10.1074/jbc.M117.787283 Abstract PDF Supplemental Data September 12, 2017 Lipids: Yang Xu, Guanqun Chen, Michael S. Greer, Kristian Mark. P. Caldo, Geetha Ramakrishnan, Saleh Shah, Limin Wu, M. Joanne Lemieux, Jocelyn Ozga, and Randall J. Weselake Multiple mechanisms contribute to increased neutral lipid accumulation in yeast producing recombinant variants of plant diacylglycerol acyltransferase 1 J. Biol. Chem. jbc.M117.811489. doi:10.1074/jbc.M117.811489 Abstract PDF Supplemental Data Protein Structure and Folding - Enzymology: Corey H Yu, Nan Yang, Jameson Bothe, Marco Tonelli, Sergiy Nokhrin, Natalia V Dolgova, Lelita T. Braiterman, Svetlana Lutsenko, and Oleg Y Dmitriev The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics. J. Biol. Chem. jbc.M117.811752. doi:10.1074/jbc.M117.811752 Abstract PDF Supplemental Data Cell Biology: Christine A Mills, Aussie Suzuki, Anthony Arceci, Jin Yao Mo, Alex Duncan, Edward D Salmon, and Michael J Emanuele Nucleolar and spindle-associated protein 1 (NUSAP1) interacts with a SUMO E3 ligase complex during chromosome segregation J. Biol. Chem. jbc.M117.796045. doi:10.1074/jbc.M117.796045 Abstract PDF Supplemental Data Immunology - Signal Transduction: Tanja Blumer, Mairene Coto-Llerena, Francois H.T. Duong, and Markus H. Heim SOCS1 is an inducible negative regulator of IFN lambda induced gene expression in vivo J. Biol. Chem. jbc.M117.788877. doi:10.1074/jbc.M117.788877 Abstract PDF Supplemental Data Enzymology - Molecular Biophysics: Henrik Hansson, Saeid Karkehabadi, Nils Mikkelsen, Nicholai R. Douglas, Steve Kim, Anna Lam, Thijs Kaper, Brad Kelemen, Katlyn K. Meier, Stephen M. Jones, Edward I. Solomon, and Mats Sandgren High-resolution structure of a lytic polysaccharide monooxygenase from Hypocrea jecorina reveals a predicted linker as an integral part of the catalytic domain J. Biol. Chem. jbc.M117.799767. doi:10.1074/jbc.M117.799767 Abstract PDF Gene Regulation: David Gonzalez, Annouck Luyten, Boris Bartholdy, Qiling Zhou, Miroslava Kardosova, Alex Ebralidze, Kenneth D. Swanson, Hanna Radomska, Pu Zhang, Susumu S. Kobayashi, Robert S. Welner, Elena Levantini, Ulrich Steidl, Gilbert Chong, Samuel Collombet, Min Hee Choi, Alan D. Friedman, Linda M. Scott, Meritxell Alberich-Jorda, and Daniel G. Tenen ZNF143 is an important regulator of the myeloid transcription factor C/EBPα J. Biol. Chem. jbc.M117.811109. doi:10.1074/jbc.M117.811109 Abstract PDF Supplemental Data Developmental Biology - Gene Regulation: Yaqiong Li, Lianjun Zhang, Yuqiong Hu, Min Chen, Feng Han, Yan Qin, Min Chen, Xiuhong Cui, Shuguang Duo, Fuchou Tang, and Fei Gao Beta-catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression J. Biol. Chem. jbc.M117.811349. doi:10.1074/jbc.M117.811349 Abstract PDF Supplemental Data Cell Biology - Signal Transduction: Zhiguo Li, Jinghui Liu, Jie Li, Yifan Kong, George Sandusky, Xi Rao, Yunlong Liu, Jun Wan, and Xiaoqi Liu Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice J. Biol. Chem. jbc.M117.810960. doi:10.1074/jbc.M117.810960 Abstract PDF Supplemental Data September 11, 2017 Protein Structure and Folding - Molecular Biophysics: Jonathan K. Williams, Alexander A. Shcherbakov, Jun Wang, and Mei Hong Protonation equilibria and pore-opening structure of the dual-histidine influenza B virus M2 transmembrane proton channel from solid-state NMR J. Biol. Chem. jbc.M117.813998. doi:10.1074/jbc.M117.813998 Abstract PDF Enzymology - RNA: Shemaila Sultana, Mihai Solotchi, Aparna Ramachandran, and Smita S. Patel Transcriptional fidelities of human mitochondrial POLRMT, yeast mitochondrial Rpo41, and Phage T7 single-subunit RNA polymerases J. Biol. Chem. jbc.M117.797480. doi:10.1074/jbc.M117.797480 Abstract PDF Supplemental Data Enzymology - Molecular Biophysics: Lilach Zattelman, Ronit Regev, Marko Ušaj, Patrick Y.A. Reinke, Sven Giese, Abraham O Samson, Manuel H Taft, Dietmar J Manstein, and Arnon Henn N−terminal splicing extensions of the human MYO1C gene fine−tune the kinetics of the three full−length myosin IC isoforms J. Biol. Chem. jbc.M117.794008. doi:10.1074/jbc.M117.794008 Abstract PDF Supplemental Data Cell Biology - Microbiology: Judith L Green, Richard J Wall, Juha Vahokoski, Noor A Yusuf, Mohd A Mohd Ridzuan, Rebecca R Stanway, Jessica Stock, Ellen Knuepfer, Declan Brady, Stephen R Martin, Steven A Howell, Isa P Pires, Robert W Moon, Justin E Molloy, Inari Kursula, Rita Tewari, and Anthony A Holder Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility J. Biol. Chem. jbc.M117.802769. doi:10.1074/jbc.M117.802769 Abstract PDF Supplemental Data Protein Structure and Folding - Molecular Biophysics: Yu-Hao Lin, De-Chen Qiu, Wen-Han Chang, Yi-Qi Yeh, U-Ser Jeng, Fu-Tong Liu, and Jie-rong Huang The intrinsically disordered N-terminal domain of galectin-3 dynamically mediates multisite self-association of the protein through fuzzy interactions J. Biol. Chem. jbc.M117.802793. doi:10.1074/jbc.M117.802793 Abstract PDF Supplemental Data Enzymology - DNA and Chromosomes: Michael J Howard and Samuel H. Wilson Processive searching ability varies among members of the gap-filling DNA polymerase X family J. Biol. Chem. jbc.M117.801860. doi:10.1074/jbc.M117.801860 Abstract PDF Supplemental Data Genomics and Proteomics: Jeovanis Gil, Alberto Ramírez-Torres, Diego Chiappe, Juan Luna-Peñaloza, Francis C Fernandez-Reyes, Bolivar Arcos-Encarnación, Sandra Contreras, and Sergio Encarnación-Guevara Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells. J. Biol. Chem. jbc.M117.784546. doi:10.1074/jbc.M117.784546 Abstract PDF Supplemental Data Cell Biology - Molecular Bases of Disease: Francesca Fortini, Francesco Vieceli Dalla Sega, Cristiana Caliceti, Giorgio Aquila, Micaela Pannella, Antonio Pannuti, Lucio Miele, Roberto Ferrari, and Paola Rizzo Estrogen receptor β-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis J. Biol. Chem. jbc.M117.790121. doi:10.1074/jbc.M117.790121 Abstract PDF Supplemental Data Signal Transduction - Microbiology: Weiming Ouyang, Pengfei Guo, Hui Fang, and David M Frucht Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation J. Biol. Chem. jbc.M117.805648. doi:10.1074/jbc.M117.805648 Abstract PDF Molecular Biophysics - Signal Transduction: Kerstin Zimmermann, Rebecca Eells, Frank Heinrich, Stefanie Rintoul, Brian Josey, Prabhanshu Shekhar, Mathias Lösche, and Lawrence J Stern The cytosolic domain of T-cell receptor ζ associates with membranes in a dynamic equilibrium and deeply penetrates the bilayer J. Biol. Chem. jbc.M117.794370. doi:10.1074/jbc.M117.794370 Abstract PDF Enzymology - Bioenergetics: Jędrzej Małecki, Magnus E Jakobsson, Angela Y.Y. Ho, Anders Moen, Arild Rustan, and Pål Ø Falnes Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation J. Biol. Chem. jbc.M117.808451. doi:10.1074/jbc.M117.808451 Abstract PDF Supplemental Data Membrane Biology - Molecular Bases of Disease: Qadeer Aziz, Yiwen Li, Naomi Anderson, Leona Ojake, Elena Tsisanova, and Andrew Tinker Molecular and functional characterization of the endothelial ATP-sensitive potassium channel J. Biol. Chem. jbc.M117.810325. doi:10.1074/jbc.M117.810325 Abstract PDF September 8, 2017 Molecular Bases of Disease - Signal Transduction: Murali K Yanda, Qiangni Liu, Valeriu Cebotaru, William B. Guggino, and Liudmila Cebotaru Histone deacetylase 6 Inhibition reduces cysts by decreasing via cAMP and Ca2+ in knockout mouse models of polycystic kidney disease J. Biol. Chem. jbc.M117.803775. doi:10.1074/jbc.M117.803775 Abstract PDF Gene Regulation - Molecular Bases of Disease: Vivekananda Kedage, Brady G Strittmatter, Paige B Dausinas, and Peter C Hollenhorst Phosphorylation of the oncogenic transcription factor ERG in prostate cells dissociates polycomb repressive complex 2 allowing target gene activation J. Biol. Chem. jbc.M117.796458. doi:10.1074/jbc.M117.796458 Abstract PDF Supplemental Data Cell Biology - Membrane Biology: Astrid Rohrbeck, Markus Höltje, Andrej Adolf, Elisabeth Oms, Sandra Hagemann, Gudrun Ahnert-Hilger, and Ingo Just The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif J. Biol. Chem. jbc.M117.798231. doi:10.1074/jbc.M117.798231 Abstract PDF Supplemental Data Protein Structure and Folding - Microbiology: Karthik Sathiyamoorthy, J Vijayalakshmi, Bhramara Tirupati, Lixin Fan, and Mark A Saper Structural analyses of the Haemophilus influenzae peptidoglycan synthase activator LpoA suggest multiple conformations in solution J. Biol. Chem. jbc.M117.804997. doi:10.1074/jbc.M117.804997 Abstract PDF Supplemental Data Protein Structure and Folding - DNA and Chromosomes: Kodai Hara, Shota Taharazako, Masanori Ikeda, Hiroki Fujita, Yoshiko Mikami, Sotaro Kikuchi, Asami Hishiki, Hideshi Yokoyama, Yoshinobu Ishikawa, Shin-ichiro Kanno, Kozo Tanaka, and Hiroshi Hashimoto Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP) J. Biol. Chem. jbc.M117.804237. doi:10.1074/jbc.M117.804237 Abstract PDF RNA - Molecular Bases of Disease: Yanli Ren, Jinhua Shang, Jinliang Li, Wenjuan Liu, Zhao Zhang, Jupeng Yuan, and Ming Yang The long noncoding RNA PCAT-1 links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma J. Biol. Chem. jbc.M116.773978. doi:10.1074/jbc.M116.773978 Abstract PDF Supplemental Data Metabolism - Methods and Resources: You Zhuo, Ciro D. Cordeiro, S. Khan Hekmatyar, Roberto Docampo, and James H. Prestegard Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in trypanosoma brucei J. Biol. Chem. jbc.M117.807495. doi:10.1074/jbc.M117.807495 Abstract PDF Neurobiology - Protein Structure and Folding: Kyle A. Lyman, Ye Han, Robert J. Heuermann, Xiangying Cheng, Jonathan E. Kurz, Reagan E. Lyman, Paul P. Van Veldhoven, and Dane M. Chetkovich Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels J. Biol. Chem. jbc.M117.802256. doi:10.1074/jbc.M117.802256 Abstract PDF Supplemental Data September 7, 2017 Protein Structure and Folding - Molecular Biophysics: Durga P. Neupane, Dante Avalos, Stephanie Fullam, Hridindu Roychowdhury, and Erik T. Yukl Mechanisms of zinc binding to the solute binding protein AztC and transfer from the metallochaperone AztD J. Biol. Chem. jbc.M117.804799. doi:10.1074/jbc.M117.804799 Abstract PDF Lipids - Enzymology: Christoph Heier, Benedikt Kien, Feifei Huang, Thomas O Eichmann, Hao Xie, Rudolf Zechner, and Ping-An Chang The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain J. Biol. Chem. jbc.M117.792978. doi:10.1074/jbc.M117.792978 Abstract PDF Enzymology - Protein Structure and Folding: Sarah M. Heissler, Krishna Chinthalapudi, and James R. Sellers Kinetic signatures of myosin-5B, the motor involved in microvillus inclusion disease J. Biol. Chem. jbc.M117.801456. doi:10.1074/jbc.M117.801456 Abstract PDF Protein Structure and Folding - Signal Transduction: Huanchen Wang and Stephen B. Shears Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities. J. Biol. Chem. jbc.M117.801845. doi:10.1074/jbc.M117.801845 Abstract PDF Molecular Bases of Disease - Genomics and Proteomics: Sophie Burel, Fabien C. Coyan, Maxime Lorenzini, Matthew R. Meyer, Cheryl F. Lichti, Joan H. Brown, Gildas Loussouarn, Flavien Charpentier, Jeanne M. Nerbonne, R. Reid Townsend, Lars S. Maier, and Céline Marionneau C-Terminal Phosphorylation of NaV1.5 Impairs FGF13-Dependent Regulation of Channel Inactivation J. Biol. Chem. jbc.M117.787788. doi:10.1074/jbc.M117.787788 Abstract PDF Supplemental Data Signal Transduction - Immunology: Mitsuyoshi Tanishima, Shigeo Takashima, Arata Honda, Daisuke Yasuda, Takashi Tanikawa, Satoshi Ishii, and Takashi MaruYama Identification of optineurin as an Interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling J. Biol. Chem. jbc.M117.813899. doi:10.1074/jbc.M117.813899 Abstract PDF Supplemental Data Signal Transduction - Protein Structure and Folding: Zhen Xu, Lokesh Gakhar, Fletcher E Bain, Maria Spies, and Ernesto J Fuentes The Tiam1 Guanine Nucleotide Exchange Factor is Auto-inhibited by its Pleckstrin Homology Coiled-Coil Extension Domain J. Biol. Chem. jbc.M117.799114. doi:10.1074/jbc.M117.799114 Abstract PDF Supplemental Data Microbiology - Molecular Bases of Disease: Shamila Sarwar, Asif Ali, Mahadeb Pal, and Pinak Chakrabarti Zinc oxide nanoparticles provide anti-cholera activity by disrupting the interaction of cholera toxin with the human GM1 receptor J. Biol. Chem. jbc.M117.793240. doi:10.1074/jbc.M117.793240 Abstract PDF Supplemental Data Cell Biology - Computational Biology: Kimon Lemonidis, Ruth MacLeod, George S Baillie, and Luke H. Chamberlain Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase J. Biol. Chem. jbc.M117.799650. doi:10.1074/jbc.M117.799650 Abstract PDF Supplemental Data Enzymology: Gregory C Campanello, Michael Lofgren, Adam L Yokom, Daniel R Southworth, and Ruma Banerjee Switch I-Dependent Allosteric Signaling In A G-Protein Chaperone-B12 Enzyme Complex J. Biol. Chem. jbc.M117.786095. doi:10.1074/jbc.M117.786095 Abstract PDF Supplemental Data September 6, 2017 Protein Structure and Folding - Immunology: Jie Yu, Xiaoxiao Wang, Tao Xu, Qiuheng Jin, Jinyuan Duan, Jie Wu, Haiyan Wu, Ting Xu, and Sheng Ye A rational approach to enhancing antibody Fc homodimer formation for robust production of antibody mixture in a single cell line J. Biol. Chem. jbc.M116.771188. doi:10.1074/jbc.M116.771188 Abstract PDF Supplemental Data Immunology: Jon A. Kenniston, Brandy M. Taylor, Gregory P. Conley, Janja Cosic, Kris J. Kopacz, Allison P. Lindberg, Stephen R. Comeau, Kateri Atkins, Jameson Bullen, Christopher TenHoor, Burt A. Adelman, Daniel J. Sexton, Thomas E. Edwards, and Andrew E. Nixon Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody J. Biol. Chem. jbc.M117.807396. doi:10.1074/jbc.M117.807396 Abstract PDF Neurobiology - Protein Structure and Folding: Zhiyi Yu and Jonathan B. Cohen Enantiomeric barbiturates bind distinct inter- and intra-subunit binding sites in a nicotinic acetylcholine receptor (nAChR) J. Biol. Chem. jbc.M117.808592. doi:10.1074/jbc.M117.808592 Abstract PDF Cell Biology - Molecular Bases of Disease: Kimberly A Cooney, Brent M Molden, Nicholas S. Kowalczyk, Susan Russell, and Giulia Baldini Lipid stress inhibits endocytosis of Melanocortin-4 Receptor from modified clathrin-enriched sites and impairs receptor desensitization J. Biol. Chem. jbc.M117.785758. doi:10.1074/jbc.M117.785758 Abstract PDF Minireview - Microbiology - Membrane Biology: Paola Sperandeo, Alessandra M. Martorana, and Alessandra Polissi The lipopolysaccharide transport (Lpt) machinery: a non-conventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria J. Biol. Chem. jbc.R117.802512. doi:10.1074/jbc.R117.802512 Abstract PDF RNA: Zhe Chen, Bin Gui, Yu Zhang, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Chongyang Wu, Lin He, Jianguo Yang, Xia Yi, Xiaohan Yang, Luyang Sun, Jing Liang, and Yongfeng Shang Identification of a 35S U4/U6.U5 Tri-snRNP Complex Intermediate in Spliceosome Assembly J. Biol. Chem. jbc.M117.797357. doi:10.1074/jbc.M117.797357 Abstract PDF Supplemental Data Signal Transduction - Molecular Bases of Disease: Eduardo Reynoso, Hua Liu, Lin Li, Anthony L. Yuan, She Chen, and Zhigao Wang Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis J. Biol. Chem. jbc.M117.799353. doi:10.1074/jbc.M117.799353 Abstract PDF September 1, 2017 Signal Transduction - Cell Biology: Praneeth Siripurapu, Dinesh Kankanamge, Kasun Ratnayake, Kanishka Senarath, and Ajith Karunarathne Two independent but synchronized Gβγ subunit−controlled pathways are essential for trailing-edge retraction during macrophage migration J. Biol. Chem. jbc.M117.787838. doi:10.1074/jbc.M117.787838 Abstract PDF Supplemental Data Molecular Biophysics - Neurobiology: John R. Bankston, Hannah A. DeBerg, Stefan Stoll, and William N. Zagotta Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b J. Biol. Chem. jbc.M117.800722. doi:10.1074/jbc.M117.800722 Abstract PDF Supplemental Data Cell Biology: Terunao Takahara, Kuniko Inoue, Yumika Arai, Keiko Kuwata, Hideki Shibata, and Masatoshi Maki The calcium-binding protein ALG-2 regulates protein secretion and trafficking via interactions with MISSL and MAP1B J. Biol. Chem. jbc.M117.800201. doi:10.1074/jbc.M117.800201 Abstract PDF Supplemental Data Membrane Biology - Molecular Biophysics: Benoîte Bourdin, Julie Briot, Marie-Philippe Tétreault, Rémy Sauvé, and Lucie Parent Negatively charged residues in the first extracellular loop of the L-type CaV1.2 channel anchor the interaction with the CaVα2δ1 auxiliary subunit J. Biol. Chem. jbc.M117.806893. doi:10.1074/jbc.M117.806893 Abstract PDF Glycobiology and Extracellular Matrices - Enzymology: Alberto J Lopez-Jimenez, Trayambak Basak, and Roberto M Vanacore Proteolytic Processing of Lysyl Oxidase like-2 in the Extracellular Matrix is Required for Crosslinking of Basement Membrane Collagen IV J. Biol. Chem. jbc.M117.798603. doi:10.1074/jbc.M117.798603 Abstract PDF Protein Structure and Folding - Molecular Biophysics: Sebastian Kostrhon, Georg Kontaxis, Tanja Kaufmann, Erika Schirghuber, Stefan Kubicek, Robert Konrat, and Dea Slade A histone-mimicking interdomain linker in a multi-domain protein modulates multivalent histone binding J. Biol. Chem. jbc.M117.801464. doi:10.1074/jbc.M117.801464 Abstract PDF Supplemental Data August 31, 2017 Molecular Biophysics - Molecular Bases of Disease: Norie Sugitani, Markus W. Voehler, Michelle S. Roh, Agnieszka M. Topolska-Woś, and Walter J. Chazin Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates J. Biol. Chem. jbc.M117.800078. doi:10.1074/jbc.M117.800078 Abstract PDF Supplemental Data Glycobiology and Extracellular Matrices - Protein Structure and Folding: Yoshihiro Ishikawa, Paul Holden, and Hans Peter Bachinger Heat shock protein 47 and 65 KDa FK506 binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum J. Biol. Chem. jbc.M117.802298. doi:10.1074/jbc.M117.802298 Abstract PDF Minireview - Bioenergetics - Methods and Resources: Hoi-Shan WONG, Pratiksha A. Dighe, Vojtech Mezera, Pierre-Axel Monternier, and Martin D. Brand Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions J. Biol. Chem. jbc.R117.789271. doi:10.1074/jbc.R117.789271 Abstract PDF Enzymology - Methods and Resources: Robert H. Scannevin, Richard Alexander, Tara Mezzasalma Haarlander, Sharon L. Burke, Monica Singer, Cuifen Hou, Yue-Mei Zhang, Diane Maguire, John Spurlino, Ingrid Deckman, Karen I. Carroll, Frank Lewandowski, Eric Devine, Keli Dzordzorme, Brett Tounge, Cindy Milligan, Shariff Bayoumy, Robyn Williams, Celine Schalk-Hihi, Kristi Leonard, Paul Jackson, Matthew Todd, Lawrence C. Kuo, and Kenneth J. Rhodes Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation J. Biol. Chem. jbc.M117.806075. doi:10.1074/jbc.M117.806075 Abstract PDF Minireview - Bioenergetics - Metabolism: Edward T Chouchani, Lawrence Kazak, and Bruce M Spiegelman Mitochondrial reactive oxygen species and adipose tissue thermogenesis: bridging physiology and mechanisms J. Biol. Chem. jbc.R117.789628. doi:10.1074/jbc.R117.789628 Abstract PDF Protein Structure and Folding - Plant Biology: Olga Otrusinová, Gabriel Demo, Petr Padrta, Zuzana Jaseňáková, Blanka Pekárová, Zuzana Gelová, Agnieszka Szmitkowska, Pavel Kadeřávek, Séverine Jansen, Milan Zachrdla, Tomáš Klumpler, Jaromír Marek, Jozef Hritz, Lubomír Janda, Hideo Iwaï, Michaela Wimmerová, Jan Hejátko, and Lukáš Žídek Conformational dynamics as a key factor of signaling mediated by the receiver domain of sensor histidine kinase from Arabidopsis thaliana J. Biol. Chem. jbc.M117.790212. doi:10.1074/jbc.M117.790212 Abstract PDF Supplemental Data Molecular Bases of Disease - Metabolism: Chunyi Liu, Steven Hutchens, Thomas Jursa, William Shawlot, Elena V. Polishchuk, Roman S. Polishchuk, Beth K. Dray, Andrea C. Gore, Michael Aschner, Donald R. Smith, and Somshuvra Mukhopadhyay Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production J. Biol. Chem. jbc.M117.804989. doi:10.1074/jbc.M117.804989 Abstract PDF Signal Transduction - Protein Structure and Folding: Chi Zhang, Darcie J. Miller, Cristina D. Guibao, Dominique M Donato, Steven K. Hanks, and Jie J. Zheng Structure-functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin J. Biol. Chem. jbc.M117.807271. doi:10.1074/jbc.M117.807271 Abstract PDF Microbiology - Genomics and Proteomics: Nichollas E Scott, Cristina Giogha, Georgina L Pollock, Catherine L Kennedy, Andrew I Webb, Nicholas A Williamson, Jaclyn S Pearson, and Elizabeth L Hartland The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD). J. Biol. Chem. jbc.M117.805036. doi:10.1074/jbc.M117.805036 Abstract PDF Supplemental Data Immunology - Membrane Biology: Silvia A. Synowsky, Sally L. Shirran, Fiona G. M. Cooke, Antony N. Antoniou, Catherine H. Botting, and Simon J. Powis The major histocompatibility complex class I immunopeptidome of extracellular vesicles. J. Biol. Chem. jbc.M117.805895. doi:10.1074/jbc.M117.805895 Abstract PDF Supplemental Data Cell Biology - Developmental Biology: Dilani G. Gamage, Eugenia Leikina, Malgorzata E. Quinn, Anthony Ratinov, Leonid V. Chernomordik, and Douglas P. Millay Insights into the localization and function of myomaker during myoblast fusion J. Biol. Chem. jbc.M117.811372. doi:10.1074/jbc.M117.811372 Abstract PDF Enzymology - Protein Structure and Folding: Frits Goedegebuur, Lydia Dankmeyer, Peter Gualfetti, Saeid Karkehabadi, Henrik Hansson, Suvamay Jana, Vicky Huynh, Bradley R. Kelemen, Paulien Kruithof, Edmund A. Larenas, Pauline J.M. Teunissen, Jerry Ståhlberg, Christina M. Payne, Colin Mitchinson, and Mats Sandgren Improving the thermal stability of cellobiohydrolase Cel7A from Hypocrea jecorina by directed evolution J. Biol. Chem. jbc.M117.803270. doi:10.1074/jbc.M117.803270 Abstract PDF Supplemental Data Signal Transduction - Immunology: Ercument Dirice, Raymond Ng, Rachael Martinez, Jiang Hu, Florence F. Wagner, Edward B. Holson, Bridget K. Wagner, and Rohit N. Kulkarni Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes J. Biol. Chem. jbc.M117.804328. doi:10.1074/jbc.M117.804328 Abstract PDF Supplemental Data August 30, 2017 Protein Structure and Folding - Immunology: Jesse I. Mobbs, Patricia T. Illing, Nadine L. Dudek, Andrew G Brooks, Daniel G Baker, Anthony W. Purcell, Jamie Rossjohn, and Julian P. Vivian The molecular basis for peptide repertoire selection in the Human Leucocyte Antigen (HLA) C*06:02 molecule J. Biol. Chem. jbc.M117.806976. doi:10.1074/jbc.M117.806976 Abstract PDF Supplemental Data Microbiology - Gene Regulation: Kyung Ku Jang, Zee-Won Lee, Bityeoul Kim, Young Hyun Jung, Ho Jae Han, Myung Hee Kim, Byoung Sik Kim, and Sang Ho Choi Identification and characterization of Vibrio vulnificus plpA encoding a phospholipase A2 essential for pathogenesis J. Biol. Chem. jbc.M117.791657. doi:10.1074/jbc.M117.791657 Abstract PDF Supplemental Data Microbiology - Protein Structure and Folding: Michael L. Barta, Jonathan P. Shearer, Olivia Arizmendi, Jacqueline M. Tremblay, Nurjahan Mehzabeen, Qi Zheng, Kevin P. Battaile, Scott Lovell, Saul Tzipori, William D. Picking, Charles B. Shoemaker, and Wendy L. Picking Single-domain antibodies pinpoint potential targets within Shigella invasion plasmid antigen D of the needle tip complex for inhibition of type III secretion J. Biol. Chem. jbc.M117.802231. doi:10.1074/jbc.M117.802231 Abstract PDF Supplemental Data Reflection - Lipids - Metabolism: Dennis E. Vance From Masochistic Enzymology to Mechanistic Physiology and Disease J. Biol. Chem. jbc.X117.815100. doi:10.1074/jbc.X117.815100 Abstract PDF Developmental Biology - Molecular Bases of Disease: Dong Feng, Zhe Chen, Kuang Yang, Shanshan Miao, Bolin Xu, Yunsi Kang, Haibo Xie, and Chengtian Zhao The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants J. Biol. Chem. jbc.M117.784017. doi:10.1074/jbc.M117.784017 Abstract PDF Supplemental Data Molecular Biophysics - DNA and Chromosomes: Artur Kaczmarczyk, Abdollah Allahverdi, Thomas B. Brouwer, Lars Nordenskiöld, Nynke H. Dekker, and John van Noort Single-molecule force spectroscopy on histone H4 tail cross-linked chromatin reveals fiber folding J. Biol. Chem. jbc.M117.791830. doi:10.1074/jbc.M117.791830 Abstract PDF Supplemental Data Signal Transduction - Enzymology: Neha Malhotra, Subramanian Karthikeyan, and Pradip K Chakraborti Phosphorylation of mycobacterial phosphodiesterase by eukaryotic-type Ser/Thr kinase controls its two distinct and mutually exclusive functionalities J. Biol. Chem. jbc.M117.784124. doi:10.1074/jbc.M117.784124 Abstract PDF Supplemental Data August 29, 2017 Glycobiology and Extracellular Matrices - Microbiology: Kathryn C. Rahlwes, Stephanie A. Ha, Daisuke Motooka, Jacob A. Mayfield, Lisa R. Baumoel, Justin N. Strickland, Ana P. Torres-Ocampo, Shota Nakamura, and Yasu S. Morita The cell envelope-associated phospholipid-binding protein LmeA is required for mannan polymerization in mycobacteria J. Biol. Chem. jbc.M117.804377. doi:10.1074/jbc.M117.804377 Abstract PDF Supplemental Data Cell Biology - Gene Regulation: Xiongjie Jin, Aijun Qiao, Demetrius Moskophidis, and Nahid F. Mivechi WITHDRAWN: Abrogation of heat shock factor 1 (Hsf1) phosphorylation deregulates its activity and lowers activation threshold, leading to obesity in mice J. Biol. Chem. jbc.M117.789354. doi:10.1074/jbc.M117.789354 Abstract PDF Supplemental Data August 28, 2017 Protein Structure and Folding - Methods and Resources: Xiaosa Wu, Yen-Hua Huang, Quentin Kaas, Peta J Harvey, Conan K Wang, Han-Shen Tae, David J Adams, and David J. Craik Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer J. Biol. Chem. jbc.M117.808386. doi:10.1074/jbc.M117.808386 Abstract PDF Protein Structure and Folding - Molecular Biophysics: Sandrine C. Stiegler, Martin Rübbelke, Vadim S. Korotkov, Matthias Weiwad, Christine John, Gunter Fischer, Stephan A. Sieber, Michael Sattler, and Johannes Buchner A chemical compound inhibiting the Aha1-Hsp90 chaperone complex J. Biol. Chem. jbc.M117.797829. doi:10.1074/jbc.M117.797829 Abstract PDF Supplemental Data Cell Biology - Developmental Biology: Manman Wang, Ling Tang, Dahai Liu, Qi-Long Ying, and Shoudong Ye The transcription factor Gbx2 induces expression of Kruppel-like factor 4 to maintain and induce naive pluripotency of embryonic stem cells J. Biol. Chem. jbc.M117.803254. doi:10.1074/jbc.M117.803254 Abstract PDF Supplemental Data Gene Regulation - Molecular Bases of Disease: Xiaoya Ma, Huabing Zhang, Xiang Xue, and Yatrik M Shah Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity J. Biol. Chem. jbc.M117.805655. doi:10.1074/jbc.M117.805655 Abstract PDF Cell Biology: Bin Xiao, Jian-Yuan Goh, Lin Xiao, Hongxu Xian, Kah-Leong Lim, and Yih-Cherng Liou Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin J. Biol. Chem. jbc.M117.787739. doi:10.1074/jbc.M117.787739 Abstract PDF Supplemental Data Immunology - Signal Transduction: Tomotsugu Takano, Chihiro Motozono, Takashi Imai, Koh-Hei Sonoda, Yoichi Nakanishi, and Sho Yamasaki Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity J. Biol. Chem. jbc.M117.800847. doi:10.1074/jbc.M117.800847 Abstract PDF Supplemental Data Metabolism - Cell Biology: Pengbo Yao, Huishan Sun, Chang Xu, Taiqi Chen, Bing Zou, Peng Jiang, and Wenjing Du Evidence for a direct crosstalk between malic enzyme and the pentose phosphate pathway via structural interactions J. Biol. Chem. jbc.M117.810309. doi:10.1074/jbc.M117.810309 Abstract PDF Supplemental Data Immunology - Molecular Bases of Disease: Yun-Jia Ning, Kuan Feng, Yuan-Qin Min, Fei Deng, Zhihong Hu, and Hualin Wang Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction J. Biol. Chem. jbc.M117.805127. doi:10.1074/jbc.M117.805127 Abstract PDF Molecular Bases of Disease - Cell Biology: Kasturi Roy, Stephanie Jerman, Levente Jozsef, Thomas McNamara, Ginikanwa Onyekaba, Zhaoxia Sun, and Ethan P. Marin Palmitoylation of the ciliary GTPase Arl13b is necessary for its stability and its role in cilia formation J. Biol. Chem. jbc.M117.792937. doi:10.1074/jbc.M117.792937 Abstract PDF Supplemental Data Supplemental Data Cell Biology - Protein Structure and Folding: Shubhi Srivastava, Mohammad Azharuddin Savanur, Devanjan Sinha, Abhijit Birje, Vigneshwaran R, Prasenjit Prasad Saha, and Patrick D'Silva Regulation of mitochondrial protein import by the nucleotide exchange factors GrpEL1 and GrpEL2 in human cells J. Biol. Chem. jbc.M117.788463. doi:10.1074/jbc.M117.788463 Abstract PDF August 27, 2017 Enzymology: Lisza M. Bruder, Robert J. Gruninger, Colyn P. Cleland, and Steven C. Mosimann Bacterial protein tyrosine phosphatase-like myo-inositol phosphatases, PhyA, in complex with the Ins(1,3,4,5)P4 and Ins(1,4,5)P3 second messengers J. Biol. Chem. jbc.M117.787853. doi:10.1074/jbc.M117.787853 Abstract PDF Supplemental Data August 25, 2017 DNA and Chromosomes: Rupesh Kumar, Pearl Nurse, Soon Bahng, Chong M Lee, and Kenneth J Marians The MukB-Topoisomerase IV Interaction Is Required for Proper Chromosome Compaction J. Biol. Chem. jbc.M117.803346. doi:10.1074/jbc.M117.803346 Abstract PDF Supplemental Data DNA and Chromosomes: Rupesh Kumar, Małgorzata Grosbart, Pearl Nurse, Soon Bahng, Claire L Wyman, and Kenneth J Marians The Bacterial Condensin MukB Compacts DNA by Sequestering Supercoils and Stabilizing Topologically Isolated Loops J. Biol. Chem. jbc.M117.803312. doi:10.1074/jbc.M117.803312 Abstract PDF Glycobiology and Extracellular Matrices - Cell Biology: Kai Song, Jianxin Fu, Jianhua Song, Brett H Herzog, Kirk Bergstrom, Yuji Kondo, J. Michael McDaniel, Samuel McGee, Robert Silasi-Mansat, Florea Lupu, Hong Chen, Harini Bagavant, and Lijun Xia Loss of mucin-type O-glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney J. Biol. Chem. jbc.M117.798512. doi:10.1074/jbc.M117.798512 Abstract PDF Signal Transduction - Enzymology: Rachel Bond, Nina Ly, and Martha S. Cyert The unique C-terminus of calcineurin isoform CNAβ1 confers non-canonical regulation of enzyme activity by Ca2+ and calmodulin J. Biol. Chem. jbc.M117.795146. doi:10.1074/jbc.M117.795146 Abstract PDF Supplemental Data Bioenergetics - Molecular Biophysics: Seiga Yanagisawa and Wayne D. Frasch Protonation-dependent stepped rotation of the F-type ATP synthase c-ring observed by single-molecule measurements J. Biol. Chem. jbc.M117.799940. doi:10.1074/jbc.M117.799940 Abstract PDF Signal Transduction - Molecular Bases of Disease: Cen Li, Soyoung Park, Xiaowen Zhang, Leonard M Eisenberg, Hong Zhao, Zbigniew Darzynkiewicz, and Dazhong Xu Nuclear Gene 33/Mig6 Regulates the DNA Damage Response through an ATM-dependent Mechanism J. Biol. Chem. jbc.M117.803338. doi:10.1074/jbc.M117.803338 Abstract PDF Cell Biology - Protein Structure and Folding: Xiangqiang Shao, Hyunook Kang, Timothy Loveless, Gyu Rie Lee, Chaok Seok, William I. Weis, Hee-Jung Choi, and Jeff Hardin Structural and functional characterization of the α-catenin·β-catenin binding interface in Caenorhabditis elegans reveals conserved requirements for cell-cell adhesion in metazoans J. Biol. Chem. jbc.M117.795567. doi:10.1074/jbc.M117.795567 Abstract PDF Supplemental Data Gene Regulation - Signal Transduction: Zariel I. Johnson, Alexandra C. Doolittle, Joseph W. Snuggs, Irving M. Shapiro, Christine L. Le Maitre, and Makarand V. Risbud TNF-α Promotes Nuclear Enrichment of TonEBP/NFAT5 to Selectively Control Inflammatory but not Osmoregulatory Responses in Nucleus Pulposus Cells J. Biol. Chem. jbc.M117.790378. doi:10.1074/jbc.M117.790378 Abstract PDF Supplemental Data August 24, 2017 Cell Biology - Signal Transduction: Zhangfei Shen, Yu Chen, Lingjuan Hong, Zhenteng Cui, Huipeng Yang, Xiaobai He, Ying Shi, Liangen Shi, Feng Han, and Naiming Zhou BNGR-A25L and -A27 are two functional G protein-coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm, Bombyx mori J. Biol. Chem. jbc.M117.803445. doi:10.1074/jbc.M117.803445 Abstract PDF Supplemental Data Metabolism - Signal Transduction: Shengli Dong, Somesh Barnawal, Anapatricia Garcia, Silvia Serrano Gomez, Steven Eastlack, Tomoo Iwakuma, Donald Mercante, Franck Mauvais-Jarvis, and Suresh K. Alahari Nischarin Inhibition Alters Energy Metabolism by Activating AMP-Activated Protein Kinase J. Biol. Chem. jbc.M117.784256. doi:10.1074/jbc.M117.784256 Abstract PDF Supplemental Data Signal Transduction - Membrane Biology: Punya Navaratnarajah, Anne Gershenson, and Elliott M. Ross The binding of activated Gαq to Phospholipase C-β exhibits anomalous affinity J. Biol. Chem. jbc.M117.809673. doi:10.1074/jbc.M117.809673 Abstract PDF Supplemental Data Minireview - Metabolism - Cell Biology: Hong Xie and M Celeste Simon Oxygen availability and metabolic reprogramming in cancer J. Biol. Chem. jbc.R117.799973. doi:10.1074/jbc.R117.799973 Abstract PDF Protein Structure and Folding - Membrane Biology: Samuel Jayakanthan, Lelita T. Braiterman, Nesrin M. Hasan, Vinzenz M. Unger, and Svetlana Lutsenko HUMAN COPPER TRANSPORTER ATP7B (WILSON DISEASE PROTEIN) FORMS STABLE DIMERS IN VITRO AND IN CELLS J. Biol. Chem. jbc.M117.807263. doi:10.1074/jbc.M117.807263 Abstract PDF Minireview - Gene Regulation - Signal Transduction: Takafumi Suzuki and Masayuki Yamamoto Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress J. Biol. Chem. jbc.R117.800169. doi:10.1074/jbc.R117.800169 Abstract PDF Minireview - Metabolism: Ruma Banerjee Introduction to the Thematic Minireview Series: Redox Metabolism and Signaling J. Biol. Chem. jbc.R117.814160. doi:10.1074/jbc.R117.814160 Abstract PDF August 23, 2017 Microbiology - Immunology: Na Zhang, Hongjun Huang, Binghe Tan, Yinglei Wei, Qingqing Xiong, Yan Yan, Lili Hou, Nannan Wu, Stefan Siwko, Andrea Cimarelli, Jianrong Xu, Honghui Han, Min Qian, Mingyao Liu, and Bing Du Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein J. Biol. Chem. jbc.M117.802090. doi:10.1074/jbc.M117.802090 Abstract PDF Microbiology - Membrane Biology: Pulkit Gupta, Zhifen Zhang, Seiji N Sugiman-Marangos, John Tam, Swetha Raman, Jean-Philippe Julien, Heather K. Kroh, D. Borden Lacy, Nicholas Murgolo, Kavitha Bekkari, Alex G Therien, Lorraine D Hernandez, and Roman A Melnyk Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor binding determinants J. Biol. Chem. jbc.M117.806687. doi:10.1074/jbc.M117.806687 Abstract PDF Supplemental Data Immunology - Molecular Bases of Disease: Xiaolei Zhuang, Norman R. Watts, Ira W. Palmer, Joshua D. Kaufman, Altaira D. Dearborn, Joni L. Trenbeath, Elif Eren, Alasdair C. Steven, Christoph Rader, and Paul T. Wingfield Chimeric Rabbit/Human Fab Antibodies Against the Hepatitis B e-antigen and Their Potential Applications in Assay, Characterization and Therapy J. Biol. Chem. jbc.M117.802272. doi:10.1074/jbc.M117.802272 Abstract PDF Supplemental Data Molecular Biophysics: Erin Bove-Fenderson, Ryo Urano, John E. Straub, and David A. Harris Cellular prion protein targets amyloid-β fibril ends via its C-terminal domain to prevent elongation J. Biol. Chem. jbc.M117.789990. doi:10.1074/jbc.M117.789990 Abstract PDF Supplemental Data Enzymology - Bioenergetics: Nidhi Adlakha, Girish H Rajacharya, and Rakesh Bhatnagar WITHDRAWN: Identification of an endogenous redox partner for lytic polysaccharide monooxygenase-based oxidative cleavage of polysaccharides J. Biol. Chem. jbc.M117.802694. doi:10.1074/jbc.M117.802694 Abstract PDF Neurobiology - Membrane Biology: Shreyas Bhat, Peter S Hasenhuetl, Ameya Kasture, Ali El-Kasaby, Michael H Baumann, Bruce E Blough, Sonja Sucic, Walter Sandtner, and Michael Freissmuth Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates J. Biol. Chem. jbc.M117.794081. doi:10.1074/jbc.M117.794081 Abstract PDF Molecular Bases of Disease - Molecular Biophysics: Paige E Cooper, Conor McClenaghan, Xingyu Chen, Anna Stary-Weinzinger, and Colin G. Nichols Conserved functional consequences of disease-associated mutations in the slide-helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel J. Biol. Chem. jbc.M117.804971. doi:10.1074/jbc.M117.804971 Abstract PDF Protein Structure and Folding - Microbiology: Xin Chen, Hiu-fu Cheng, Junwei Zhou, Chiu-yeung Chan, Kwok-fai Lau, Stephen Kwok-wing Tsui, and Shannon Wing-ngor Au Structural basis of the PE-PPE protein interaction in Mycobacterium tuberculosis J. Biol. Chem. jbc.M117.802645. doi:10.1074/jbc.M117.802645 Abstract PDF Supplemental Data Enzymology - Lipids: Kariona A Grabińska, Ban H Edani, Eon Joo Park, Jan R Kraehling, and William C Sessa A conserved carboxy-terminal RxG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity J. Biol. Chem. jbc.M117.806034. doi:10.1074/jbc.M117.806034 Abstract PDF August 22, 2017 Minireview - Enzymology - Protein Structure and Folding: John A. Latham, Ian Barr, and Judith P. Klinman At the confluence of ribosomally synthesized peptide modification and radical S-adenosylmethionine (SAM) enzymology J. Biol. Chem. jbc.R117.797399. doi:10.1074/jbc.R117.797399 Abstract PDF Gene Regulation - Metabolism: Tiantian Zhang, Pengli Bu, Joey Zeng, and Ales Vancura Increased heme synthesis in yeast induces a metabolic switch from fermentation to respiration even under conditions of glucose repression J. Biol. Chem. jbc.M117.790923. doi:10.1074/jbc.M117.790923 Abstract PDF August 21, 2017 Glycobiology and Extracellular Matrices - Protein Structure and Folding: Andrew Hettle, Alexander Fillo, Kento Abe, Patricia Massel, Benjamin Pluvinage, David N Langelaan, Steven P Smith, and Alisdair B Boraston Properties of a family 56 carbohydrate-binding module and its role in the recognition and hydrolysis of β-1,3-glucan. J. Biol. Chem. jbc.M117.806711. doi:10.1074/jbc.M117.806711 Abstract PDF Supplemental Data Microbiology - Signal Transduction: Richard C Sobe, Whitney G Bond, Caitlin K Wotanis, Josiah P Zayner, Marybeth A Burriss, Nicolas Fernandez, Eric L Bruger, Christopher M Waters, Howard S Neufeld, and Ece Karatan Spermine inhibits Vibrio cholerae biofilm formation through the NspS-MbaA polyamine signaling system J. Biol. Chem. jbc.M117.801068. doi:10.1074/jbc.M117.801068 Abstract PDF Supplemental Data August 18, 2017 Molecular Bases of Disease - Metabolism: Amy Lyons, Michael Coleman, Sarah Riis, Cedric Favre, Ciara H. O'Flanagan, Alexander V. Zhdanov, Dmitri B. Papkovsky, Stephen D. Hursting, and Rosemary O'Connor Insulin-like Growth Factor-1 signalling is essential for Mitochondrial Biogenesis and Mitophagy in cancer cells J. Biol. Chem. jbc.M117.792838. doi:10.1074/jbc.M117.792838 Abstract PDF Supplemental Data Cell Biology - Bioenergetics: Fernando Gomes, Flavio Romero Palma, Mario H. Barros, Eduardo T. Tsuchida, Helena G. Turano, Thiago G. P. Alegria, Marilene Demasi, and Luis E. S. Netto Proteolytic cleavage by the IMP complex or Oct1 peptidase controls the localization of the yeast peroxiredoxin Prx1 to distinct mitochondrial compartments J. Biol. Chem. jbc.M117.788588. doi:10.1074/jbc.M117.788588 Abstract PDF Supplemental Data Metabolism - Microbiology: Siddharth K. Tripathi, Tao Xu, Qin Feng, Bharathi Avula, Xiaomin Shi, Xuewen Pan, Melanie M. Mask, Scott R. Baerson, Melissa R. Jacob, Ranga Rao Ravu, Shabana I. Khan, Xing-Cong Li, Ikhlas A. Khan, Alice M. Clark, and Ameeta K. Agarwal Two Plant-Derived Aporphinoid Alkaloids Exert Their Antifungal Activity by Disrupting Mitochondrial Iron-Sulfur Cluster Biosynthesis J. Biol. Chem. jbc.M117.781773. doi:10.1074/jbc.M117.781773 Abstract PDF Supplemental Data Molecular Bases of Disease - Signal Transduction: Trisha Bansal, Emeli Chatterjee, Jasdeep Singh, Arjun Ray, Bishwajit Kundu, V. Thankamani, Shantanu Sengupta, and Sagartirtha Sarkar Arjunolic Acid, a Peroxisome Proliferator-Activated Receptor Alpha Agonist Regresses Cardiac Fibrosis by Inhibiting Non-canonical TGF-β Signaling. J. Biol. Chem. jbc.M117.788299. doi:10.1074/jbc.M117.788299 Abstract PDF Supplemental Data August 17, 2017 Neurobiology - Cell Biology: Khalil Saadipour, Michael MacLean, Sean Pirkle, Solav Ali, Maria Luisa Lopez-Redondo, David L. Stokes, and Moses V Chao The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor J. Biol. Chem. jbc.M117.788729. doi:10.1074/jbc.M117.788729 Abstract PDF Supplemental Data Signal Transduction - Protein Structure and Folding: Jayshree Mishra, Jugal Kishore Das, and Narendra Kumar Janus kinase-3 regulates adherens junction and epithelial mesenchymal transition through Beta-catenin J. Biol. Chem. jbc.M117.811802. doi:10.1074/jbc.M117.811802 Abstract PDF Supplemental Data August 16, 2017 Microbiology - Signal Transduction: Adam J Schaenzer, Nathan Wlodarchak, David H Drewry, William J Zuercher, Warren E Rose, Rob Striker, and John-Demian Sauer A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA J. Biol. Chem. jbc.M117.808600. doi:10.1074/jbc.M117.808600 Abstract PDF Supplemental Data August 15, 2017 Molecular Bases of Disease - Protein Structure and Folding: Nicolas Privat, Etienne Levavasseur, Serfildan Yildirim, Samia Hannaoui, Jean-Philippe Brandel, Jean-Louis Laplanche, Vincent Béringue, Danielle Seilhean, and Stéphane Haïk Region-specific protein misfolding cyclic amplification reproduces brain tropism of prion strains J. Biol. Chem. jbc.M117.793646. doi:10.1074/jbc.M117.793646 Abstract PDF Supplemental Data Gene Regulation - Genomics and Proteomics: Mark B Meyer, Nancy A Benkusky, Martin Kaufmann, Seong Min Lee, Melda Onal, Glenville Jones, and J. Wesley Pike A Kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene Cyp27b1 essential for vitamin D3 activation J. Biol. Chem. jbc.M117.806901. doi:10.1074/jbc.M117.806901 Abstract PDF August 14, 2017 Metabolism: Jamie Whitfield, Sabina Paglialunga, Brennan K. Smith, Paula M. Miotto, Genevieve Simnett, Holly L. Robson, Swati S. Jain, Eric A. F. Herbst, Eric M. Desjardins, David J. Dyck, Lawrence L. Spriet, Gregory R. Steinberg, and Graham P. Holloway Ablating TBC1D1 impairs contraction-induced sarcolemmal glucose transporter type 4 redistribution, but not insulin-mediated responses in rats J. Biol. Chem. jbc.M117.806786. doi:10.1074/jbc.M117.806786 Abstract PDF Cell Biology - Signal Transduction: Shusaku Shibutani, Hana Okazaki, and Hiroyuki Iwata Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1) J. Biol. Chem. jbc.M117.776443. doi:10.1074/jbc.M117.776443 Abstract PDF Supplemental Data Enzymology - Molecular Biophysics: Raja F. Kawas, Robert L. Anderson, Sadie R. Bartholomew Ingle, Yonghong Song, Arvinder S. Sran, and Hector M. Rodriguez A small molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle J. Biol. Chem. jbc.M117.776815. doi:10.1074/jbc.M117.776815 Abstract PDF Enzymology: Andrew J. Knappenberger, Sneha Grandhi, Reena Sheth, Md. Faiz Ahmad, Rajesh Viswanathan, and Michael E. Harris Phylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase J. Biol. Chem. jbc.M117.798769. doi:10.1074/jbc.M117.798769 Abstract PDF Supplemental Data Metabolism - Molecular Bases of Disease: Sanghoon Kwon, Sunmi Seok, Peter Yau, Xiaoling Li, Byron Kemper, and Jongsook Kim Kemper Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3 J. Biol. Chem. jbc.M117.778720. doi:10.1074/jbc.M117.778720 Abstract PDF Supplemental Data August 10, 2017 Molecular Bases of Disease - Immunology: Mahmoud G. Khalafalla, Lucas T. Woods, Jean M. Camden, Aslam A. Khan, Kirsten H. Limesand, Michael J. Petris, Laurie Erb, and Gary A. Weisman P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy J. Biol. Chem. jbc.M117.790741. doi:10.1074/jbc.M117.790741 Abstract PDF Supplemental Data Molecular Biophysics - Neurobiology: Esben Trabjerg, Fredrik Kartberg, Søren Christensen, and Kasper D. Rand Conformational characterization of Nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part J. Biol. Chem. jbc.M117.803320. doi:10.1074/jbc.M117.803320 Abstract PDF Supplemental Data Gene Regulation - Computational Biology: Cassiano Langini, Amedeo Caflisch, and Andreas Vitalis The ATAD2 Bromodomain Binds Different Acetylation Marks on the Histone H4 in Similar Fuzzy Complexes J. Biol. Chem. jbc.M117.786350. doi:10.1074/jbc.M117.786350 Abstract PDF Supplemental Data Molecular Biophysics - Protein Structure and Folding: Moustafa Algamal, Rashik Ahmed, Naeimeh Jafari, Bilal Ahsan, Joaquin Ortega, and Giuseppe Melacini Atomic-Resolution Map of the Interactions between an Amyloid Inhibitor Protein and Amyloid Beta (Aβ) Peptides in the Monomer and Protofibril States J. Biol. Chem. jbc.M117.792853. doi:10.1074/jbc.M117.792853 Abstract PDF Supplemental Data August 9, 2017 Metabolism - Bioenergetics: Naresh C Bal, Sushant Singh, Felipe C.G. Reis, Santosh K Maurya, Sunil Pani, Leslie A. Rowland, and Muthu Periasamy Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice J. Biol. Chem. jbc.M117.790451. doi:10.1074/jbc.M117.790451 Abstract PDF August 8, 2017 Cell Biology - RNA: Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Anastasia Sorochinsky, James R Hackney, Zachery Gentry, Sejong Bae, Peter King, and L. Burt Nabors Hu Antigen R (HuR) multimerization contributes to glioma disease progression J. Biol. Chem. jbc.M117.797878. doi:10.1074/jbc.M117.797878 Abstract PDF Supplemental Data August 7, 2017 Enzymology - Molecular Biophysics: Xuejun Yu, Dimitri Niks, Ashok Mulchandani, and Russ Hille Efficient reduction of CO2 by the molybdenum-containing formate dehydrogenase from Cupriavidus necator (Ralstonia eutropha). J. Biol. Chem. jbc.M117.785576. doi:10.1074/jbc.M117.785576 Abstract PDF Supplemental Data Gene Regulation - DNA and Chromosomes: Hogyu David Seo, Yoonjung Choi, Minhoo Kim, Keunsoo Kang, Takeshi Urano, and Daeyoup Lee The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast J. Biol. Chem. jbc.M117.790824. doi:10.1074/jbc.M117.790824 Abstract PDF Supplemental Data View by section Subscribe to Papers in Press Email (eTOCs) RSS syndication Submit your work to JBC. You'll be in good company. Submit Authors Editorial Policies Editorial Board Editorial Board (PDF) Classics Virtual Issues Most Read / Cited Archive About the JBC Announcements Newsroom Awards Copyright Permissions Subscribers Advertise Contact JBC ASBMB Today Journal of Lipid Research Molecular & Cellular Proteomics Copyright © 2017 American Society for Biochemistry and Molecular Biology Online ISSN 1083-351X Advertisement Advertisement