HOME / THERAPEUTIC AREAS / ALAGILLE SYNDROME (ALGS) THERAPEUTIC AREAS FOCAL SEGMENTAL GLOMERULOSCLEROSIS (FSGS) IgA NEPHROPATHY (IgAN) CLASSICAL HOMOCYSTINURIA (HCU) N-GLYCANASE 1 (NGLY1) DEFICIENCY ALAGILLE SYNDROME (ALGS) CYSTINURIA BILE ACID SYNTHESIS DISORDERS (BASD) CEREBROTENDINOUS XANTHOMATOSIS (CTX) PEROXISOME BIOGENESIS DISORDER-ZELLWEGER SPECTRUM DISORDER (PBD-ZSD) ALAGILLE SYNDROME (ALGS) Alagille syndrome, or ALGS, is a rare genetic disorder that can affect the liver, heart, skeleton, eyes and kidneys. Symptoms and severity of ALGS can vary greatly from one person to another. Symptoms often develop during the first three months of life and include interrupted bile flow (cholestasis), jaundice, poor weight gain and growth, and severe itching (pruritis). ALGS is an autosomal dominant disorder, meaning that a child may be affected when one parent passes on a copy of the abnormal gene (JAG1 or NOTCH2). In other cases, the gene mutation can occur spontaneously, meaning it is not inherited from a parent. According to the National Organization for Rare Disorders (NORD), the estimated incidence of ALGS is between 1 in 30,000 to 1 in 45,000 births. Learn about treatment discovery efforts for ALGS. Resources: National Organization for Rare Disorders; Alagille Syndrome Alliance. Cholestasis Testing Laboratory: EGL Genetics Genetic testing for pediatric patients with cholestasis or prolonged jaundice without a known cause. The test checks for 66 potential genetic causes of cholestasis. Learn more about the genetic cholestasis panel PATIENT ADVOCACY ORGANIZATIONS Find resources, community and support through the patient advocacy organizations below. MA-319 © 2021 Travere Therapeutics, Inc. All rights reserved. For US audiences. Chenodal®, Cholbam® and Total Care HUB® are registered trademarks of Travere Therapeutics, Inc. Thiola® and Thiola EC® are registered trademarks of Mission Pharmacal Company. Terms and Conditions | Privacy Policies | Cookie Preferences This website uses cookies for optimal site functionality. By continuing to use this website, you consent to our use of cookies. To change your cookie preferences, click on "Cookie Settings" or for more information, please see ourPrivacy Policies. Accept All Cookies Cookie Settings