NEWSROOM CONTACT Workflow ABOUT FASTING MIMICKING TECHNOLOGY OUR BRANDS HEALTHSPAN PROGRAM PLANT-BASED THERAPEUTICS SCIENCE FASTING MIMICKING TECHNOLOGY THE INCREDIBLE STORY NATURE HAS TAUGHT US. Since organisms arose, the waxing and waning of their food resources has been a constant in nature. When food is scarce, this exerts compulsory pressure on all life forms to respond – or risk extinction. And so it is that through time, all species that survived have developed adaptive mechanisms during fasting that confer a survival advantage. When food is plentiful, the cells grow. When food is scarce, the cells stop growing and enter into a protective and recycling mode that conserves energy and optimizes cellular functions. One key mechanism triggered by fasting is called autophagy. In fact, the discovery and description of autophagy mechanisms was so monumental to understanding cellular health that the discoverer won the 2016 Nobel Prize in Physiology or Medicine. As it turns out, the mechanisms of autophagy and other survival processes are unsurprisingly similar in all species, down to their molecular pathways. From simple organisms such as yeast and fruit flies, to more complex organisms such as mice, other mammals, and humans, these pathways are conserved. Specifically, during fasting, the body acts to conserve energy by minimizing any growth activities. This is achieved by shutting down the food signal sensors such as insulin-like growth factor-1 (IGF-1), the target of rapamycin (TOR), and protein kinase A (PKA). In scientific terms, this process is called “down-regulation of nutrient sensing pathways.” Fasting-induced reductions in IGF-1, TOR, and PKA signaling result in increased cellular maintenance and protection, including increased activation of stress resistance, and removal and replacement of old, worn out cellular parts. So, these fasting responses promote resilience. Here lies one of nature’s greatest untold stories and L-Nutra’s vision. By continuing research into how fasting impacts us at the cellular level, and identifying the pathways through which fasting benefits our bodies, we can leverage our research to develop different products to promote health and longevity. Why not just fast? Despite the potential benefits, fasting is hard to do. For many, it’s not safe to do. So, our nutritechnology is focused on making fasting safer, effective, easier, and more practical while targeting specific outcomes. Our Fasting Mimicking Technology Platform encompasses the basic principles we’ve uncovered and continue to research about fasting, and allows us to develop different formulations targeted to different solutions. In general health and wellness, we have used it to develop and continuously improve the Fasting Mimicking Diet and related products. We’re also leveraging it to define and develop a novel class of fasting mimicking drugs to potentially prevent or treat a number of lifestyle-related chronic illnesses. Using the power of autophagy and other survival mechanisms invoked by fasting while reducing the stress and improving safety is our goal. Developing specific nutritechnology products targeted for specific uses – that’s the power of the Fasting Mimicking Technology Platform. ONGOING RESEARCH THE POTENTIAL IMPACT OF FASTING-MIMICKING TECHNOLOGY ON HEALTH AND LONGEVITY. Since the stress of fasting and fasting-mimicking affect nearly every cell in an organism, emerging evidence points to the potential of a multitude of beneficial effects on cells and organ systems. EXPLORE SCIENTIFIC ARTICLES SCIENTIFIC COLLABORATIONS DEVELOPING NEXT-GEN SOLUTIONS. L-Nutra is constantly entering into scientific partnerships to develop and test the next generation applications of our Fasting Mimicking Technology. To date, we have more than 30 completed or ongoing research collaborations around the globe.* University of Southern California Policlinico San Martino Genova University of Genova, Italy Policlinico Paolo Giaccone Palermo University of Verona University of Rome Tor Vergata Leiden University University Hospital Heidelberg, Heidelberg, Germany Charité Universitätsmedizin Berlin Indiana University Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Sapienza University, Rome, Italy Leiden University Medical Centre, The Netherlands University Hospital, “Policlinico Paolo Giaccone” of Palermo, Italy Galway Clinic and National University of Galway (NUIG), Ireland University of Miami Stanford University School of Medicine Ospedale Policlinico S. Martino, Genova, Italy *These institutions do not directly or indirectly endorse L-Nutra products or services EXPLORE STUDIES AND CLINICAL TRIALS EXPLORE ONGOING, PLANNED AND COMPLETED HUMAN TRIALS Footer Join us as you reach for your full potential. Filter out the noise and focus on longevity and science backed products that help you live healthier, longer. Together we're moving forward. JOIN THE MOVEMENT About Our Brands Fasting Mimicking Technology Healthspan Program Plant Based Therapeutics Science Home Newsroom Privacy Policy Terms Of Use Contact Us ©2021 L-Nutra Inc. All rights reserved Accept Privacy Policy