About Us Exelixis, Inc., from the Greek word for “evolution,” is a biopharmaceutical company committed to developing and commercializing small molecule therapies with the potential to improve the treatment of cancer. Over the past decade, we have established a broad development platform, laying the foundation for our continued efforts to bring new therapies for cancer to patients in need. The history of our lead compounds, cabozantinib and cobimetinib, tells the story of our evolution as a company. Each of these compounds were discovered in our own laboratories and advanced by us into clinical development. In addition, we have leveraged our earlier stage drug discovery and development capabilities to establish multiple partnerships and collaborations with leading pharmaceutical and biopharmaceutical partners. These alliances are designed to advance the development of multiple Exelixis-discovered therapies, and allow Exelixis to focus on maximizing the potential of cabozantinib. Exelixis has worldwide rights to cabozantinib, which we believe could have the potential to treat a wide variety of cancers. Cabozantinib received its initial regulatory approval for a single indication in 2012, and is marketed for that indication under the trade name COMETRIQ®. Cabozantinib is also the subject of a broad, global clinical development program that includes approximately 45 ongoing or planned clinical trials. Exelixis is the sponsor of two active global, randomized phase 3 pivotal trials: the METEOR trial in metastatic renal cell carcinoma, for which positive top-line results were announced in July 2015, and the CELESTIAL trial in advanced hepatocellular carcinoma. Founded and incorporated in 1994, Exelixis is headquartered in South San Francisco, California. We are committed to excellence in all aspects of our business and are dedicated to improving the care of, and outcomes for, patients with cancer. About Us COMETRIQ® Pipeline Clinical Trials Medical Information Investors & Media Responsibility Careers About Us Management Board of Directors Collaborations Locations Contact Us © Exelixis, Inc. 2015 Website design: Hane Chow, Inc. Privacy Terms of Use

Locations and Directions Exelixis, Inc. 210 East Grand Avenue So. San Francisco, CA 94080 (650) 837-7000 phone (650) 837-8300 fax Directions to Exelixis, Inc. 101 Northbound from San Francisco Airport: Take 101 North toward San Francisco. Take the Grand Avenue exit, exit 425A, toward So San Francisco. Turn right onto East Grand Ave. 210 East Grand Ave is on your right-hand side. 101 Southbound from San Francisco: Take 101 South. Take the Grand Avenue exit. Turn left at the first light. Immediately turn left at the first light onto Grand Avenue (which will become East Grand Avenue) 210 East Grand Ave is on your right-hand side. About Us COMETRIQ® Pipeline Clinical Trials Medical Information Investors & Media Responsibility Careers About Us Management Board of Directors Collaborations Locations Contact Us © Exelixis, Inc. 2015 Website design: Hane Chow, Inc. Privacy Terms of Use