Welcome to Huber Kältemaschinenbau AG, Germany Contact | Sitemap | Privacy policy | Imprint | Wish list Products Applications Service & Download Company News Contact www.huber-online.com > English > Applications > Industry Solutions Chemicals / Pharmaceuticals Products and Solutions for Chemicals / Pharmaceuticals Precise temperature control in chemical reaction engineering has a significant influence on the production output or the results of the research. In many research laboratories, pilot plants and kilo laboratories Unistat temperature control systems ensure exact temperatures and stable process conditions. With our Unistat-Hybrid technology we are also offering solutions for very large reaction vessels with a volume of 10,000 litres and more. Unistats can be considered as leading technology based on their thermodynamic properties. This is not least due to the fact that the devices are subject to continuous development together with process engineers and are being adapted to the current requirements. Unistats are therefore predestined for chemical and bio-reactors, autoclaves, miniplant and pilot plants, reaction blocks, calorimeters and distillation plant. The devices inspire users with their short heating and cooling times, large temperature ranges without the need for fluid changes as well as a high stability and reproducibility in a common temperature control process. Typical applications Low temperature reactions, Syntheses, Separating processes, Miniplant, Kilo laboratory, Pilot plant, Reactor systems, Autoclaves, Scale-Up, Process development, Combinatorial chemistry , etc. Reference customers BASF, Bayer, Lanxess, Organichem, Roche, Merck, Glaxo Smith Kline, Novartis, Lonza, Saltigo, EVONIK, Wackerchemie, Henkel, DSM, Wuxi AppTec, AstraZeneca, Syngene Biocon, Reliance Pharma, HEL Products & Solutions Calibration baths Calibration baths are used in Quality Assurance in industry and research. The modular concept is based on the combination of a calibration bath with a Unistat. This determines the temperature range and the speed of change of temperature. The calibration bath made out of stai... Show models... Circulation heaters Circulation heaters with Pilot ONE for temperature control of external open systems in a compact construction and suitable for installation in plant. With a circulation pump made out of stainless steel. Adjustable overtemperature protection according to DIN 12876.... Show models... Circulation heat exchangers Heat exchanger system HTS with a circulation pump for primary side connection to an existing supply of cooling water. These compact circulation coolers provide a cooling circuit with a stable pressure and delivery stream as well a precisely adjustable operating temperature. ... Show models... Dynamic temperature control systems For more than 30 years, the dynamic thermoregulation of the Unistat range introduced a revolution in fluid temperature control. Unistats are the ideal solution for fast and precise thermal control of externally connected applications. In comparison to other circulators, the ... Show models... Chillers Many applications depend on a reliable source of cooling. Circulating chillers in the Unichiller range offer an ideal solution for environmentally friendly and economical cooling in laboratory and industry. There are over 50 air and water cooled models to choose from, with c... Show models... Bath and circulation thermostats The circulators are split into two product lines, the CC-models and the simpler KISS models. Both product lines represent classically constructed laboratory circulators with open baths. Baths and circulators for heating applications up to +300 °C are available, as well as mo... Show models... Chemicals / Pharmaceuticals Temperature control solutions for the Pharmaceutical industry Huber offers a wide range of temperature control systems and associated accessories. The perfect unit for any application can be found within the range and help is always at hand to guide users to the right product for their application. This assistance is in the form of engineering expertise, well qualified and experienced partners and our wide range of Case Studies freely available on our web site. Our portfolio can be broadly split into three ranges: Uni­stats (hydraulically sealed thermostats), Open Bath Thermostats and chillers. Typical applications Reactors Laboratory instruments Sample preparation Process cooling Quality control Material testing Process development Scale-up Miniplants Pilot plants Kilolabs and much more Process thermostats Unistats are designed to control temperature in a wide variety of applications across all industries. They are used extensively in many departments and applications in the Pharma­ceutical industry from small scale research to large scale production over a temperature range of -125 °C to 425 °C. Their ability to rapidly change the temperature of the circulating heat transfer fluid (HTF) and the advanced self-tuning PID controller provides the application with extremely tight and responsive temperature control. This can be seen in the Case Study collection on the Huber website. Baths and Circulators Our product line with classical constructed open baths and circulators are split into two ranges. The KISS range are simple units designed for small bench top applications. They have a simple controller and are easy to use. The CC range has the more extensive Pilot ONE controller. Used in smaller application and especially when the rapid response of the Unistats is (perhaps) not required. Providing temperature control from -90 °C to 300 °C, they are an effective and useful laboratory work horse. Chillers Chillers Unichillers are specifically designed to remove heat but are also capable of temperature control within ±0,1 K if fitted with an optional heater. The chiller range is split into two groups. The OLÉ range is for more simple applications such as cooling condensers on low-volume rotary evaporators or low volume bioreactors. The controller is simple and easy to use. The T range are floor standing chillers designed for larger applications, e.g. cooling the condenser on a high volume rotary evaporators or used as a “central chilled water supply” for the whole laboratory. They are also very often used to control the temperature of large bioreactors. mwälzkühler sind speziell zur Wärmeabfuhr entwickelt, können jedoch auch mit einer optionalen Heizung ausgestattet werden und regeln dann mit einer Genauigkeit von ±0,1 K. High precision temperature control in Research, Development Research & Development Huber units provide stable and predictable temperature control. This performance removes an unpredictable variant from the research. Analytical laboratory These labs commonly use simple chillers (OLÉ range) to remove heat from sensitive Analytical instruments. Scale up The rapid response of Unistats make them a common feature to keep the increased energy in larger reactions under tight temperature control. Manufacturing Can be “low” or “high” volume batches. Formulation Typically, bench-top open bath systems and chillers are used in various applications. Bioproduction Unichillers fitted with heaters provide economic and reliable temperature control on Bio Reactors from Bench scale 1-litre fermenters to 3,000-litre Production scale Bio Reactors. Continuous flow Unistats and open bath units are used to reliably and accurately control the temperature of the reaction zones within the reactor. Quality control Procedure intended to ensure that raw ingredients, purchased compounds etc. a finished product under development or a finished product is within specification. Application examples Glass reactors Racketed glass reactors are a common tool. The ability to control the temperature of the reaction mass depends on the speed at which the jacket’s temperature can be changed to transfer thermal energy through the glass wall. The speed of transfer depends on the thermal qualities and design of the reactor and the Delta-T between the jacket and reaction mass. Glass reactors are inherently sensitive to pressure (typically the maximum permissible jacket pressure is 0.5 bar) and thermal shock (caused by the difference in temperature between the jacket and the reaction mass). Unistats have Variable Pressure Control (VPC) and a Delta-T limit to protect against both. In addition, the unique “Process Safety Over Temperature” that can be activated within the standard “Over Temperature” function will ensure that the pump and cooling system continue to operate in the event that a (e.g) thermal runaway is powerful enough to activate the “Over Temperature” protection. Glass lined reactors The metal component of the reactor will have a different expansion coefficient to the glass lining. To protect against stripping the glass by heating or cooling too quickly, the ramp rate can be set and controlled to either change the temperature of the jacket at a rate that does not endanger the glass lining or to be programmed in steps so that a “dwell” time allows the glass and metal to settle at the same temperature before the next change in temperature. Stainless steel reactors These reactors are robust and are typically not subject to damage from either jacket pressure or rapid thermal changes. Continuous flow reactors Flow reactors are becoming more common in research and production. Huber units from the simple CC-304B up to large Unistats are used on this application. Some of these reactors have a high flow resistance. Unistats provide sufficient pressure to ensure maximum heat transfer flow for the best possible temperature control in the reaction zones within the Flow reactor. Pressure reactors Unistats are capable of extremely rapid temperature changes to control (for example) the high energy reactions often carried out in Pressure Reactors (glass/metal). The T range of Unistats are often used for high temperature reactions of this kind. Being hydraulically sealed there are no vapours from the heat transfer fluid. To further protect the heat transfer fluid, a simple “Expan­sion Tank Sealing Kit” facilitates a low flow of Nitrogen vapour to hold the fluid in the expansion tank under an inert vapour blanket. Bioreactors Often, bioreactors can only use water or water/glycol as an HTF. After a process, the bioreactors need to be cleaned and sterilised “Cleaned In Place” (CIP) and “Sterilised in Place” (SIP). These routines are carried out at temperatures up to 120 °C using steam (The Huber Unichiller T-H temperature range can be extended to +120 °C). Before this can take place, the bioreactor‘s jacket must be drained of the water/glycol. Using a series of valves the reactor jacket can be drained into a holding tank and on completion of SIP. The system can be refilled by starting the chiller’s pump. The holding tank/expansion tank can be fabricated by Huber separately. Pipework, valves etc. must be carried out locally. Controlled Rate Freeze & Thaw Some preparations need to be frozen at a predefined rate and then thawed at a predefined rate. The built-in ”Program“ feature in the Pilot ONE allows the creation of multiple programs that can be either stored in the Pilot ONE memory or onto a Thumb drive via the USB interface. The creation of a program is highly flexible yet extremely simple to realise thanks to the simple graphic display which clearly shows each step in the program as it is created and when it is completed. The frozen blocks of medical preparation can be thawed out in a special bath. These baths are temperature con­trolled using a programmed Unichiller-eo. The ”eo“ – external open version of Unichiller range enables direct contact of the heat exchange medium (Water-Glycol mixture) with the baths for efficient heat transfer. Unistat technology can be also applied for the freeze and thaw applications. Glove Box The temperature control of diverse applications inside the glove box can be provided with Unistats, chillers and immersion coolers from the TC range. Rotary evaporators Huber chillers have a low internal volume which means that the generated cooling power is more concentrated on the application. Instead of wasting cooling power on a massive reservoir, more applications can be attached. Rheometers, Viscometers To provide accurate and constant temperature control of a sample while under test, the Ministat or a unit from the “K” series are used. Compact, flexible and providing thermal stability to 0.02 K, these units can be ideal for controlling viscometer samples. . Analytical lab equipment Diverse analytical laboratory equipment such as X-ray diffractometers, mass spectrometer, etc. produce heat which has to be removed effectively. Huber chillers as source of external cooling with its compact design and small foot print will save precious space in labs. Milling machines Milling machines The mills grind up samples into the nano range. The grinding action generates heat which needs to be removed. This installation is with Unichiller 045T. Sales Contacts Catalogues & Brochures Newsroom & Exhibitions Case Studies 3-2-2 Warranty Registration Subscribe to the Newsletter Quotation Request Distributors & Representatives Download Center Questions? Our application specialists are happy to advise you in a non-binding manner and to answer your questions about our thermoregulation solutions. You can reach our Sales hotline at: +49 (0)781 9603-123 © Peter Huber Kältemaschinenbau AG, all rights reserved Home | Contact | Terms & Conditions | Imprint | Sitemap