ABOUT US OUR FOCUS OUR PRODUCTS SCIENCE FUNDING PROGRAMS NEWSROOM INVESTORS About Narcolepsy Narcolepsy is a rare, chronic, debilitating neurological disorder of sleep-wake state instability. Narcolepsy impacts approximately 165,000 Americans and is primarily characterized by excessive daytime sleepiness, cataplexy, and other manifestations of REM sleep dysregulation, which intrude into wakefulness. In most patients, it is caused by the loss of hypocretin, a neuropeptide in the brain that supports sleep-wake state stability. This disorder affects men and women equally, with typical symptom onset in adolescence or young adulthood; however, it can take up to a decade to be properly diagnosed. Narcolepsy can cause significant burden on patients and their families, affecting their ability to perform routine tasks, limit achievement at school and work, impact social relationships and cause impairment in overall quality of life. LEARN MORE 0% n=173 agreed that the disorder is life changing 0% n=135 agreed that they never feel like a "normal" person 0% n=159 agreed that life is a daily struggle 0% n=152 agreed that it has affected important moments in their lives 0% n=130 reported social changes, like not going out as much to events, dinners, movies, and family events 0% n=71 reported physical changes, like changing jobs, moving, and being unable to cook or bathe when no one is around 0% n=57 reported emotional changes, like not showing emotions as much DOWNLOAD PDF Harmony Biosciences 630 W. Germantown Pike, Suite 215 Plymouth Meeting, PA 19462 HarmonyBiosciences.com Harmony Biosciences name and logo are registered trademarks. ©2021 Harmony Biosciences. All Rights Reserved. US-HAR-2100055/Oct 2021 ABOUT US LEADERSHIP CULTURE ETHICS/COMPLIANCE FUNDING PROGRAMS CONTACT US PRIVACY POLICY TERMS OF USE OUR FOCUS ABOUT NARCOLEPSY SCIENCE ADVANCING THE SCIENCE SAFETY DATA SHEET NEWSROOM PRESS RELEASES INVESTORS SOCIAL MEDIA LINKEDIN TWITTER COMMUNITY GUIDELINES SITEMAP By continuing to browse this website, you are agreeing to accept our use of cookies, To learn more about our Privacy policy, click here. X