Home Products Bioassays Promega offers an extensive toolbox of reporter bioassays to characterize and develop novel monoclonal antibody (mAb) and cell-based therapeutics. These assays are useful for interrogating a range of biological functions, including Fc effector activity, immune checkpoint modulation, T cell activation, and cytokine and growth factor signaling. We maintain a dynamic portfolio of quantitative, accurate and precise bioassays and can partner with drug developers in the early stages of biologic development to ensure that our bioassays meet your needs. Maximize your assay performance with GloMax plate readers. Compare Instruments Learn about Bioassays Shop Bioassay products Bioassay Product Groups Cytokine and Growth Factor Assays Cell-based bioluminescent reporter assays for cytokine immunotherapy targets. Fc Effector Activity Bioassays MOA-based functional bioassays for use in antibody screening, characterization, potency testing and stability studies. Immune Checkpoint Bioassays Functional cell-based reporter bioassays to measure activity of biologics drugs designed to target immune checkpoint receptors. Primary Cell Bioassays PBMC effector cells and a choice of popular target cells to measure ADCC activity. T Cell Activation Bioassays ICH-prequalified bioassays that enable simple, scalable solutions for drug screening and development. Top Bioassay Products for Your Lab ADCC Reporter Bioassay, V Variant Measure potency and stability of antibodies mediating ADCC through the high-affinity human FcγRIIIa-V receptor. G7015, G7010, G7016, G7018, G7102, GA1130 PD-1/PD-L1 Blockade Bioassay Measure the ability of biologics to block immune checkpoint signals J1250, J1255, J1252, J1191, J1195, J1201 VEGF Bioassay Measure VEGF activation and inhibition through KDR (VEGFR2). GA2001, GA2005, GA1082, J2371 Bioassay Resources Webinar Tips and Tools for Successful Immunotherapy Bioassay Development Webinar Bioactivity Assays: Putting the Puzzle Together An Introduction to Bioassays Bioassays are analytical methods for measuring the concentration or potency of a substance through its effects on a living system. This assessment is generally achieved through comparison of the response of a test substance with a that of a standard. These assays can utilize live organisms (in vivo) or tissues or cells (in vitro). Some common categories of bioassays include flow cytometry, proliferation, apoptosis and functional reporter bioassays. Bioassays are essential for the development of pharmaceuticals as they can provide critical data on potency and stability of drug products. Bioassays are also frequently used to ensure quality of manufacturing processes and perform lot release testing. Furthermore, these assays are used in the establishment of dose-response relationships that determine safe and efficacious levels of drug products. In addition, bioassays can provide evidence to confirm biocomparability of innovator and biosimilar products. Ultimately, an effective bioassay is reliable, standardized and reflective of a drug’s mechanism of action. Related Cell Biology Products and Resources Categories Cell Biology Cell Health Assays Cell Line and Sample Identification Cell Signaling Energy Metabolism Luciferase Assays Related Groups Cell Viability and Cytotoxicity Assays Luminometers Microplate Readers Guides and Selectors Cell Viability Assay Guide Reporter Genes and their Applications Live-Cell Kinetic Assays for Time Course Analysis Luminometer and Microplate Reader Selection Guide Top Products GloMax® Discover System CellTiter-Glo® 2.0 Assay NanoBRET™ Target Engagement Kinase Assays Let's find the product that meets your needs. Talk to a Scientist Maria Spain Don't miss out! Stay notified of Promega events, products and news. Sign Up Need Assistance? Contact Promega Customer and Technical Support Local Contact +31 (0)71 532 42 44 Products & Resources Products Applications Custom Capabilities Resources About Promega Company Info ISO Certification Corporate Responsibility Press Releases Careers © 2021 Promega Corporation, an affiliate of Promega Benelux BV. All rights reserved. Legal and Trademarks Privacy Policy Terms and Conditions Trademarks Promotional Terms and Conditions Terms and Conditions of Sale and Services Manage Cookie Consent English – Belgium Promega's Cookie Policy Close We use cookies and similar technologies to make our website work, run analytics, improve our website, and show you personalized content and advertising. Some of these cookies are essential for our website to work. For others, we won’t set them unless you accept them. To find out more about cookies and how to manage cookies, read our Cookie Policy. If you are located in the EEA , the United Kingdom, or Switzerland, you can change your settings at any time by clicking Manage Cookie Consent in the footer of our website. Manage My Cookies Reject All Cookies Yes, I Accept