HOME BIOVISIONS CHI3L2 GNA13 H3K36ME2 MUSCULIN BCM1 BLOG CONTACT US IMPDH2- en HPRT-expressie en een prognostische significantie bij preoperatieve en postoperatieve patiënten met osteosarcoom | Lieven Lieven | 0 Comment Osteosarcoom is een van de meest agressieve bottumoren bij jongeren en adolescenten. Groei van efficiënte therapeutische keuzes blijft ontbreken vanwege de complexiteit van de genomische achtergrond. In eerder werk hebben we een door proteomics geleide drug gebruikt om mogelijke remedies voor osteosarcoom te ontdekken. Ons vervolgonderzoek onthulde dat een door de FDA goedgekeurd immunosuppressivum, mycofenolaatmofetil (MMF), gericht op inosine-5′-fosfaatdehydrogenase (IMPDH) -enzymen, een antitumoreffect heeft dat veelbelovend leek voor aanvullend onderzoek en medische proeven. Profilering van IMPDH2 en hypoxanthine-guaninefosforibosyltransferase (HPRT), de belangrijkste purine-metaboliserende enzymen, kan het begrip van de betekenis van het purinemetabolisme bij osteosarcoom verdiepen en bewijs leveren voor uitgebreid gebruik van MMF in de kliniek. Binnen het huidige onderzoek, onderzochten we reeksen van IMPDH2 en HPRT in biopsie van 127 exemplaren en na chemotherapie weefsels in 20 gevallen van high-grade osteosarcoom patiënten gebruik te maken van immunohistochemische ( IHC ) evaluatie . Er zijn Cox-regressieanalyses uitgevoerd om de prognostische betekenis van alle enzymen te achterhalen. De resultaten gaven aan dat lage HPRT-bereiken aanzienlijk zijn gerelateerd aan een overmatig Enneking-stadium (P = 0,023) en gemetastaseerd staan (P = 0,024). Univariate en multivariate analyses lieten zien dat patiënten met een lage HPRT-expressie kortere gevallen van totale overleving hebben [HR 1,70 (1,01-2,84), P = 0,044]. Bovendien zijn buitensporige IMPDH2/HPRT-ratio’s in gelijke mate gerelateerd aan kortere gevallen van totale overleving [HR 1,67 (1,02-2,72), P = 0,039]. De reeksen van de enzymen zijn bovendien onderzocht in weefsels na chemotherapie . De uitkomsten bevestigden dat primaire IMPDH2-expressie gerelateerd was aan kortere metastasevrije overleving [HR 7,42 (1,22-45,06), P = 0,030]. Deze resultaten bevelen een prognostische waarde aan van expressiepatronen van purine-metaboliserende enzymen voor het pre- en post-chemotherapie-interval van osteosarcoomremedie. Kenmerkend voor het moleculaire en immuunpanorama van de hondenblaas De meeste kankers Transitional cell carcinoma (TCC), ook wel urotheelcarcinoom, is de meest voorkomende blaas meeste vormen van kanker in mensen en honden . Ongeveer een kwart van de menselijke TCC zijn spier-invasieve en in verband met een overmatige risico van verlies van het leven van metastase. Canine TCC (cTCC) tumoren zijn meestal hoogwaardig en spierinvasief . Gedeelde overeenkomsten in gevaar elementen , histopathologie en medische presentatie raden dat CTCC kon functioneren van een mannequin voor de evaluatie van nieuwe therapieën die zal therapieën informeren voor menselijke spierinvasieve TCC. Het doel van dit onderzoek was om cTCC te karakteriseren op de moleculaire graad om de drijvende krachten achter oncogenese en druggable targets te bepalen. We voerden volledige exome-sequencing (WES) uit van 11 cTCC- tumoren en drie gematchte reguliere monsters, waarbij we 583 varianten in eiwitcoderende genen uitvonden . De meest voorkomende variant was een V-naar-E missense-mutatie in BRAF, herkend in vier van de 11 monsters (36%) via WES. Sanger-sequencing herkende BRAF-varianten in acht van de identieke 11 cTCC-monsters, naast in 22 van de 32 in formaline gefixeerde paraffine ingebedde (FFPE) cTCC-monsters, wat wijst op een totale prevalentie van 70%. RNA-Seq werd uitgevoerd bijpassende de genexpressieprofielen van CTCC tumoren met regelmatige blaas weefsel . cTCC- tumoren vertoonden opwaartse regulatie van genen die betrokken zijn in de celcyclus, DNA- herstel en antivirale immuniteit. We bovendien analyseerde het immuunsysteem panorama van CTCC gebruik te maken van het immuunsysteem gen handtekeningen en immunohistochemische ( IHC ) evaluatie . Een subset van tumoren had kenmerken van een verschroeiende tumormicro- omgeving (TME) en vertoonde overmatige expressie van handtekeningen gerelateerd aan volledige respons op PD-1/PD-L1-blokkade in de meeste kankers van de menselijke blaas . Gemultiplexte digitale ruimtelijke profilering van invasieve borsttumoren van zwarte en blanke meisjes De NanoString GeoMx Digital Spatial Profiling (DSP) is een gloednieuw gemultiplext platform dat de overvloed aan tumor- en immuungerelateerde eiwitten kwantificeert in een ruimtelijk opgeloste methode . We uitgevoerd DSP voor het gelijktijdig evalueren van 52 analyten in ruimtelijk gescheiden weefsel compartimenten geschetst door pan-cytokeratine expressie. We hebben daarentegen eiwitdoelen tussen 94 Afro-Amerikaanse / zwarte en 65 Europese Amerikaanse / blanke gevallen , tumor- en stromale weefselcompartimenten , oestrogeenreceptor-alfa (ER) -positieve en ER-negatieve instanties en onderzochten mogelijke biomarkers voor overleving. Van 33 analyten met stevige teken voor de evaluatie , de resultaten zijn zeer repliceerbaar. Voor een subset van markers onthulden correlatieve analyses tussen DSP-analyten en conventionele immunohistochemie ( IHC ) scores redelijke tot zeer robuuste associaties tussen de 2 platforms. Eveneens , DSP analyten en scores genexpressie zijn concordante 21 van de 25 merkers met overlap tussen de 2 datasets. Een aantal analyten die uiteenliepen van ER- stand , en van de 25 onderzochte immuunmarkers, hadden 14 een grote inverse verwantschap met ER-expressie. B7-homoloog 3 (B7-H3; gecodeerd door CD276) was de enige analyt die op een groot onderscheid naar ras wees, namelijk afname in elk van de tumor- en stromale compartimenten bij zwarte meisjes . DSP markers die zijn gerelateerd aan de overleving opgenomen CD8, CD25, CD56, CD127, EpCAM, ER, Ki-67, en STING. We concluderen dat DSP een milieuvriendelijk apparaat is voor het screenen van tumor- en immuungerelateerde markers in een gelijktijdige mode en resultaten oplevert die in overeenstemming kunnen zijn met gevestigde immuunprofileringstests. DSP immuun te analyseren zijn omgekeerd gerelateerd aan ER expressie, in schikking met een grote lichaamsbouw van het eerdere werk dat papierwerk toegenomen immuun infiltratie in ER-negatieve borstkanker kanker . Deze ervaring is gebleken dat de scores van de B7-H3 eiwit zijn geweest aanzienlijk afnemen in de borst kanker van Black meisjes in contrast met witte meisjes , een intrigerende ontdekking dat de replicatie in vereist onpartijdige en raciaal talrijke vrouwelijke bevolking. Terugkerende kinderachtige inflammatoire myofibroblastische tumor van mesenterium – casusrapport en overzicht van beeldvormingsbevindingen Inflammatoire myofibroblastische tumoren (IMT) zijn ongewoon delicate weefsel tumoren van intermediaire maligne potentie met een neiging voor inheemse herhaling. Hoewel ze zullen gebeuren in enig opzicht leeftijd teams , prevalentie bij zuigelingen is buitengewoon ongewoon en hun imaging traits mag niet goed beschreven. Een 3-maanden oude vrouwelijke peuter geïntroduceerd met regelmatig progressieve maag uitzetting met niemand koorts of gewichtsvermindering . Ze had een grote, slecht gedefinieerde homogene hypodense laesie van 8,4 × 11,4 × 11,3 cm (APxTraxSag) in de maag en vertoonde een lichte verbetering van het onderscheid bij vertraagde verzending. Ze onderging een verkennende laparotomie met totale excisie van de mesenteriale massa, waarvan de histopathologie duidde op IMT. Ze had een recidief binnen 6 maanden van volledige resectie met een goed gedefinieerde heterogeen versterkende laesie met een afmeting van 1,8 × 1,8 × 2,3 cm (APxTraxSag) in het juiste paravesicale gebied dat tegen de blaas aanligt zonder invasie met een analoge laesie met een afmeting van 4,4 × 2,1 × drie cm (APxTraxSag) in het linker subdiafragmatische gebied dat grenst aan de bovenste bodem van de milt (geen invasie). Aangezien de chirurgische ingreep bij onze aangedane persoon splenectomie en gedeeltelijke cystectomie met zich mee zou brengen, was voor haar een systemische remedie met ceritinib (anaplastisch lymfoomkinase [ALK]-remmer) bedoeld, waarmee ze na 2 maanden een bijna volledige respons had. Total Protein from Human Tumor Tissue: Bladder P1235010 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Bone P1235023 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Brain P1235035 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Breast P1235086 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Colon P1235090 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Esophagus P1235106 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Gallbladder P1235118 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Kidney P1235142 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Liver P1235149 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Lung P1235152 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Lymphoma P1235161 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Leiomyosarcoma P1235172 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Neurofibroma P1235177A Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Neurilemmoma P1235177B Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Oschea P1235182 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Ovary P1235183 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Pancreas P1235188 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Parathyroid P1235189 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Parotid P1235190 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Pharynx P1235199 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Prostate P1235201 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Rectum P1235206 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Skin P1235218 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Melanoma P1235218A Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Spleen P1235246 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Stomach P1235248 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Synoviosarcoma P1235257 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Testis P1235260 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Thymus P1235264 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Thyroid P1235265 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Tonsil P1235268 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Ureter P1235273 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Uterus P1235274 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Lymphoma, Hodgkin's P1235161A Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Skeletal Muscle P1235171 Biochain 1 mg EUR 320 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Small Intestine P1235226 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total RNA from Human Tumor Tissue: Adrenal R1235004-10 Biochain 10 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Bladder R1235010-10 Biochain 10 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Bone R1235023-10 Biochain 10 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Breast R1235086-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Colon R1235090-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Esophagus R1235106-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Kidney R1235142-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Liver R1235149-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Lung R1235152-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Ovary R1235183-10 Biochain 10 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Parotid R1235190-10 Biochain 10 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Rectum R1235206-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Melanoma R1235218A-10 Biochain 10 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Stomach R1235248-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Synoviosarcoma R1235257-10 Biochain 10 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Thymus R1235264-10 Biochain 10 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Thyroid R1235265-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Tonsil R1235268-10 Biochain 10 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Uterus R1235274-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total Protein from Human Tumor Tissue: Small Intestine: Duodenum P1235101 Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Tumor Tissue: Lymphoma, Non-Hodgkin's P1235161B Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total RNA from Human Tumor Tissue: Colon, sigmoid R1235095-50 Biochain 50 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Total RNA from Human Tumor Tissue: Small Intestine R1235226-10 Biochain 10 ug EUR 351 Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. Human Total PSA (t-PSA) ELISA Kit PRB-5049-TOTAL Cell Biolabs 96 assays EUR 572 Matching Pair - Total Protein from Human Primary Tumor and Metastatic Tumor Tissue (PM): Breast P8235086-PM Biochain 0.2 mg x2 EUR 1228 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Metastatic Tumor Tissue (PM): Colon P8235090-PM Biochain 0.2 mg x2 EUR 1228 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Metastatic Tumor Tissue (PM): Kidney P8235142-PM Biochain 0.2 mg x2 EUR 1228 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Metastatic Tumor Tissue (PM): Liver P8235149-PM Biochain 0.2 mg x2 EUR 1228 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Metastatic Tumor Tissue (PM): Lung P8235152-PM Biochain 0.2 mg x2 EUR 1228 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Metastatic Tumor Tissue (PM): Rectum P8235206-PM Biochain 0.2 mg x2 EUR 1228 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Metastatic Tumor Tissue (PM): Stomach P8235248-PM Biochain 0.2 mg x2 EUR 1228 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Human Total PSA (t-PSA) ELISA Kit PRB-5049-TOTAL-5 Cell Biolabs 5 x 96 assays EUR 2283 Replacement Nose Cone LE3001A3 GenDepot Ea EUR 97 Total Protein from Human Diabetic Tissue: Adrenal P1236004Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Brain P1236035Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Colon P1236090Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Esophagus P1236106Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Heart P1236122Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Kidney P1236142Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Liver P1236149Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Lung P1236152Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Pancreas P1236188Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Skin P1236218Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Spleen P1236246Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Total Protein from Human Diabetic Tissue: Stomach P1236248Dia Biochain 1 mg EUR 461 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Normal Tissue (PP): Breast P8235086-PP Biochain 0.2 mg x2 EUR 639 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Normal Tissue (PP): Colon P8235090-PP Biochain 0.2 mg x2 EUR 639 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Normal Tissue (PP): Kidney P8235142-PP Biochain 0.2 mg x2 EUR 639 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Normal Tissue (PP): Liver P8235149-PP Biochain 0.2 mg x2 EUR 639 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Normal Tissue (PP): Lung P8235152-PP Biochain 0.2 mg x2 EUR 639 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Normal Tissue (PP): Rectum P8235206-PP Biochain 0.2 mg x2 EUR 639 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total Protein from Human Primary Tumor and Normal Tissue (PP): Stomach P8235248-PP Biochain 0.2 mg x2 EUR 639 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total RNA from Human Primary and Metastatic Tumor Tissue: Breast R8235086-PM-10 Biochain 2x10 ug EUR 650 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total RNA from Human Primary Tumor and Normal Tissue: Breast R8235086-PP-10 Biochain 2x10 ug EUR 439 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total RNA from Human Primary and Metastatic Tumor Tissue: Colon R8235090-PM-10 Biochain 2x10 ug EUR 650 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total RNA from Human Primary Tumor and Normal Tissue: Colon R8235090-PP-10 Biochain 2x10 ug EUR 439 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total RNA from Human Primary and Metastatic Tumor Tissue: Kidney R8235142-PM-10 Biochain 2x10 ug EUR 650 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total RNA from Human Primary Tumor and Normal Tissue: Kidney R8235142-PP-10 Biochain 2x10 ug EUR 439 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total RNA from Human Primary and Metastatic Tumor Tissue: Liver R8235149-PM-10 Biochain 2x10 ug EUR 650 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Matching Pair - Total RNA from Human Primary Tumor and Normal Tissue: Liver R8235149-PP-10 Biochain 2x10 ug EUR 439 Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. Een buitensporige index van verdenking is vereist om IMT te onderscheiden van verschillende veelvoorkomende oorzaken van mesenteriale overvloed bij jongeren en de functie van radioloog is in dit opzicht van essentieel belang. Aangeboren recidief met abutment echter zonder invasie van omringende constructiefactoren voor de intermediaire kwaadaardige pathologie van IMT en zal een aanwijzing geven voor de prognose. Systemische remedie is efficiënt bij patiënten die ALK optimistisch zijn en een schadelijke chirurgische ingreep moet worden voorkomen. Leave a Reply Your email address will not be published. Required fields are marked * Comment Name * Email * Website Save my name, email, and website in this browser for the next time I comment. Post navigation PREVIOUS Previous post: NEXT Next post: Related Post Centromere Protein I (CENP-I) wordt opgereguleerd bij maagkanker, voorspelt een slechte prognose en bevordert de proliferatie en migratie van tumorcellen Centromere Protein I (CENP-I) wordt opgereguleerd bij maagkanker, voorspelt een slechte prognose en bevordert de proliferatie en migratie van tumorcellen Dit onderzoek was gericht op het onderzoeken van de expressie en mobiele werking van het centromeer huishouden van eiwitten (CENP’s), met name centromeer eiwit I (CENP-I), bij de meeste maagkankers (GC) en erkende de READ MORE READ MORE Nec-1s Nec-1s Alternative name 5 – ((7-Cl-1H-indol-3-yl) methyl) -3-methylimidazolidine-2,4-dione); 7-Cl-O-Nec-1 Peptide sequence: No Appearance: Solid yellow CAS #: 852391-15-2 Molecular formula: C₁₃H₁₂ClN₃O₂ Molecular weight: 277.71 Purity: ≥96% by TLC and LC-MS Solubility: READ MORE READ MORE PureExo Exosome Isolation Kit for Cell Culture Media PureExo Exosome Isolation Kit for Cell Culture Media Exosome isolation kits A high-efficiency exosome isolation kit can be of great help to all exosome researchers. 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