MENU SEARCH NEWS & EVENTS NEWS DUTCH-NORDIC ALLIANCE FOR PRECISION CANCER MEDICINE LAUNCHED Dutch-Nordic Alliance for Precision Cancer Medicine launched 26-11-2021 The Nordic countries (Denmark, Sweden, Norway, and Finland) are setting up national clinical precision cancer trials together, modeled on the very successful DRUP trial in the Netherlands. On 11-16 November 2021, a Memorandum of Understanding was signed to this effect by the leaders of the DRUP and the Nordic Precision Medicine Trial Network (ProTarget in Denmark, MEGALit in Sweden, IMPRESS-Norway, and FIN-PROVE in Finland). A ‘Triple win’ The partners agreed to harmonize study designs, define similar clinical endpoints, and share data. All study cohorts will be opened in parallel in all the Nordic trials, and opened cohorts will be shared in a collaborative database including open and closed DRUP-cohorts. ‘This is "a triple win” - for cancer patients, investigators, and industry partners’, says Kjetil Tasken from IMPRESS-Norway, ‘as we will now be able to generate and gather evidence more rapidly on very rare combinations of diagnosis, mutation, and treatment to allow for early implementation of new cancer medicines.’ Drug Rediscovery Protocol The DRUP (Drug Rediscovery Protocol) is a nationwide Dutch study in which small groups of patients with advanced cancer and no further treatment options are treated with off-label precision drugs, based on their molecular tumor profile. The first results of the DRUP study were published in Nature in 2019. The DRUP was launched in 2016, after a large genomics study, based on whole genome sequencing of patients’ tumor DNA, had revealed that in 13% of all cases, DNA mutations were present for which registered medicines used for other cancer types were already on the market. ‘In the DRUP, we grant patients access to these medicines, and at the same time build up a sound knowledge base,’ says Emile Voest from the Netherlands Cancer Institute and DRUP. International collaboration Henk Verheul from Radboud university medical center and DRUP: ‘When patient numbers are very small, as is the case in this type of personalized cancer treatment, international collaborations are extremely important to be able to include patients as well as build evidence. We will now be able to help more patients, and at the same time gain more knowledge about treating cancer patients in a way that takes both molecular tumor profile and tumor type into account.’ Now that the Netherlands and all the Nordic countries have joined forces in clinical research, the overall population base has more than doubled. ‘This is an important start,’ says Kjetil Tasken. ‘By collaborating successfully, we hope to position for bigger European collaboration.’ The facts (as of 16.11.2021): DRUP trial (the Netherlands): Opened for inclusion in Q3 2016. Included 1873, 939 started treatment in cohorts (plus 130 patients in Stage 3 studies). 28 drugs, 3 combinations, 2 additional drugs committed. ProTarget (Denmark): Opened for inclusion 01.09.2020. Included 500+ patients for molecular profiling, 86 prescreened with potential target, 47 included for treatment and opened 34 cohorts. 12 drugs (15 in 2022) MEGALiT (Sweden): Opened for inclusion 22.10.2020. Included 54 patients for molecular profiling, 1 initiated (7 allocated) for treatment and opened 3 (4) cohorts. 4 drugs. IMPRESS-Norway (Norway): Opened for inclusion 1.04.2021. Included 100+ patients for molecular profiling, 26 for treatment and opened 23 cohorts. 8 drugs, increasing to 23 by Q1 2022. FINPROVE (Finland): Opens for inclusion Q1 2022 (or sooner). Study will include 250 for treatment. 12 drugs, increasing to 15 by Q2 2022. Clinical research DRUP Emile Voest group International collaborations metastasized cancer Precision Oncology WGS Whole Genome Sequencing Share this story Support our science? LEARN MORE Today's research for tomorrow's cure About us The Netherlands Cancer Institute is among the world’s best comprehensive cancer centers, combining innovative fundamental, translational, and clinical research with dedicated patient care. Our research institute gratefully acknowledges funding from the Dutch Ministry of Health, Welfare and Sport, the Dutch Cancer Society, and individual donors. Contact Plesmanlaan 121 1066CX Amsterdam 020 512 9111 communicatie@nki.nl Quick links Vacancies News Contact us Media & Press Follow us on Disclaimer Privacy statement Cookies This site uses cookies No thanks Got it