→ Geoclock® Press Coated Tablet (tab-in-tab) Geoclock® is a validated tab in tab (press coated tablet) oral drug delivery technology that allows for timed release of active ingredient from the tablet (oral chronotherapy), independent of food or pH. Geoclock® can additionally be used for multiple pulse delivery of one or more drugs with pre-determined time intervals between the pulses, or to target colonic release of drugs. Where more than one drug is included, the delivery profile can be different for each API. Geoclock® is easily manufactured using conventional production equipment, minimizing the need for capital investment. Geoclock® is a dry-coated tablet with an active drug core inside an outer tablet layer comprising a mixture of hydrophobic wax and brittle material. This configuration generates a pH-independent lag-time prior to the release of the active drug. After the pre-defined and configurable lag-time the inner tablet releases the active drug either as a burst or with a controlled release pattern. The controlled release characteristics of the inner core can be modified to achieve the desired profile. Geoclock® can be used to create chronotherapy-focused drug delivery that is independent of the location in the GI tract, pH or food. Examples of the application of Geoclock® include: A burst release after a long lag-time or a slow release rate after a short lag-time Drug delivery specifically at the colonic level, which is valuable for drugs targeted for colonic absorption Multiple pulse release e.g. to mimic multiple daily dosing of conventional formulations CONTACT US Your name Your email Your company Your message I agree to the privacy and cookie policy SUBMIT WE ARE AVAILABLE FOR YOU CONTACT US Expert and agile CDMO for classic and complex solid forms from early development to commercial manufacturing and packaging : A team for your product. USEFUL LINKS Overview Contacts Careers Nos offres d’emplois SERVICES Early Stage Program Technology Transfer Bulk manufacturing Pharmaceutical Packaging Supply Chain Quality Charter RECENT POST Stagiaire Pharmacien Indus Bac +5/+6 pour 6 mois 2 December 2021 Why using the Veratrak plateform ? 2 December 2021 CONTACT Tel : +33 4 74 95 20 20 Office Address: 55 Rue du Montmurier, 38070 Saint-Quentin-Fallavier, France Privacy and Cookie Policy - Terms and Conditions - Legal Notice - Copyright © 2021 Skyepharma Production SAS. All rights reserved.