Episkin About us Models & Applications Customer care Training Scientific references Order Episkin Academy HomeEye irritation Eye irritation RAW MATERIALS / ESAC opinion in June 24th, 2016 The SkinEthic™ HCE method has been peer reviewed by ESAC (2016-02) and complies with regulatory use. CONTEXT The implementation of the SkinEthic™ HCE method, as a validated reference method in the OECD test guidelines TG 492 is already considered. The draft of TG492 on Reconstructed human Cornea-like Epithelium test method for eye hazard potential is currently under review by the states members of OECD with an approval expected by summer 2017. Our corneal model and corresponding protocols (for liquids and for solids) are designed to comply with regulatory purposes to classify and label chemicals regarding in vitro ocular irritation assessment. MODELS SkinEthicTM HCE - Human Corneal Epithelium PROTOCOL PRINCIPLE SkinEthicTM HCE model can be used for in vitro eye irritation assessment with one protocol dedicated to liquids and another to solids. DETAILED ASSAY PROCEDURE SkinEthicTM HCE eye irritation test method for liquids (Click here to download the quick flow chart or click here to download full detailed protocol). SkinEthicTM HCE eye irritation test method for solids (Click here to download the quick flow chart or click here to download the full detailed protocol). Do not hesitate to get information on our training sessions or to contact our technical support. REFERENCES Multi-laboratory validation of SkinEthicTM HCE test method for testing serious eye damage/eye irritation using liquid chemicals. N. Alépée, V. Leblanc, E. Adriaens, M.-H. Grandidier, D. Lelièvre, M. Meloni, L. Nardelli, C.S. Roper, E. Santirocco, F. Toner, A. Van Rompay, J. Vinall, J. Cotovio. Toxicology In Vitro, 31: 43-53, 2016. Multi-laboratory validation of SkinEthicTM HCE test method for testing serious eye damage/eye irritation using solid chemicals and overall performance of the test method with regard to solid and liquid chemicals testing. N. Alépée, E. Adriaens, M.-H. Grandidier, M. Meloni, L. Nardelli, C. J. Vinall, F. Toner, C. S. Roper, A. R. Van Rompay, V. Leblanc, J Cotovio. Toxicology In Vitro, 34: 55-70, 2016. Epicskin Skinethic World leader in tissue engineering for in vitro human skin and epithelial models Contact us EPISKIN 4, rue Alexander Fleming 69366 - Lyon Cedex 7 FRANCE Phone: +33 4 37 28 22 00 Fax: +33 4 37 28 22 01 E-mail: info@episkin.com Menu News About us Customer Care Scientific references FAQ Contact Legal Notice 2017 © Copyright - EPISKIN Back to the top