we are in social networks With the direct participation of Moscow State University. M.V. Lomonosov russian english PROGRAMMED AGING JONAH SKULACHEVA INVESTMENT PROJECT DEVELOPMENT METHOD STAGES OF PROJECT DEVELOPMENT RESULTS PUBLICATIONS PROJECT PARTICIPANTS QUESTION ANSWER CONTACTS Home " Jonah Skulacheva H at the turn of the 1960s and 70s. V.P. Skulachev and his colleagues at Moscow State University together with the group of Professor E.M. Lieberman at the USSR Academy of Sciences were busy testing the validity of P. Mitchell's chemiosmotic hypothesis (Nobel Prize in Chemistry for 1978), who postulated the presence of an electrical potential difference on the mitochondrial membrane. The results of this work, published in the journal Nature (222, 1076-8), showed that some compounds, lipophilic cations (for example, phosphonium ions), are capable of targeted penetration into mitochondria, driven by an electric field on the mitochondrial membrane (the minus sign inside the mitochondria ). In 1974, such compounds were named by the famous American biochemist D. Green "Skulachev ions". In the early 70s. V.P. Skulachev, professor L.S. Yaguzhinsky and academician S.E. Severin suggested that penetrating cations can be used by mitochondria as "electric locomotive molecules" for the accumulation of uncharged substances attached to these cations. In the late 90s. British biochemist M.P. Murphy used this approach to try to create a mitochondria-targeted antioxidant. He added vitamin E to the lipophilic ion of triphenylalkylphosphonium. Unfortunately, this substance, as well as its somewhat more successful version, in which ubiquinone is used instead of vitamin E, has not yet found application in practice, apparently due to its strong prooxidant effect and lack of effectiveness in low doses. The viability of the entire approach was questioned . Однако, в 2003 г. группа академика В.П. Скулачева начала разработку нового митоходриально-адресованного антиоксиданта. Чтобы принципиально повысить его эффективность был использован пластохинон — вещество из самого насыщенного кислородом места в живой природе — хлоропластов растений. Было сконструировано и синтезировано вещество SkQ1, эффективность которого оказалась выше предыдущих аналогов в сотни раз. ПОЛОЖЕНИЕ о порядке хранения и защиты персональных данных для сайта (Митотех) skq-project.ru +7 (495) 939-59-45 Электронная почта info@skq-project.ru 2008 создание сайта: © 2008-2014 НИИ Митоинженерии МГУ