Zum Inhalt springen SELENOMED diagnostics for your health Start Selen Produkte Kontakt Sprache: Diagnostik selenOtest ELISA Ein kolorimetrischer Enzym-gekoppelter Immuntest für die quantitative Bestimmung von humanem Selenoprotein P (SELENOP) im Serum Sie möchten den selenOtest ELISA bestellen oder mehr Informationen erhalten? Bitte rufen Sie uns an unter +49 179 5034279 oder schreiben uns eine Email an order@selenomed.com Produktspezifikationen Produkt-Name selenOtest ELISA Synonyme Selenoprotein P ELISA, SELENOP ELISA, SEPP1 ELISA Produkt-Code STE Verwendungszweck Der selenOtest ELISA wurde für die quantitative Messung von menschlichem Selenoprotein P (SELENOP, SeP, SELP, SEPP1) Konzentrationen in verdünnten Serumproben entwickelt und validiert. Assay-Format 96 well Mikrotiterplatte Nachweismethode kolorimetrisch (450 nm) Reaktivität Human Probenvolumen* 5 – 10 µL Probenart Serum Assay Zeit 4 – 5 Stunden Assay Sensitivität* Ca. 10 µg/L (ungefähr 400-fach unter dem Serumgehalt eines gesunden Menschens) Detektionsbereich* Ca. 5 – 700 µg/L Quantifizierungsbereich* Ca. 10 – 350 µg/L (entspricht 0.4 – 14 mg/L in einer unverdünnten Serumprobe) Lagerungsbedingungen gekühlt bei 2 – 8°C Haltbarkeit 6 Monate Restriktionen Nur für Forschungszwecke. * Lot spezifische Angaben Dokumente zum Download: Lot STE.21002: Referenzen: Die nachstehenden Veröffentlichungen verwenden den selenOtest ELISA, einen Sandwich ELISA zur Quantifizierung von Selenoprotein P (SELENOP ): 2021 Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study Kamil Demircan, Ylva Bengtsson, Qian Sun, Annie Brange, Johan Vallon-Christersson, Eddy Rijntjes, Martin Malmberg, Lao H Saal, Lisa Rydén, Åke Borg, Jonas Manjer, Lutz Schomburg Redox Biol. 2021 Sep 21;47:102145. doi: 10.1016/j.redox.2021.102145. Trace element profile and incidence of type 2 diabetes, cardiovascular disease and colorectal cancer: results from the EPIC-Potsdam cohort study Maria Cabral, Olga Kuxhaus, Fabian Eichelmann, Johannes F Kopp, Wiebke Alker, Julian Hackler, Anna P Kipp, Tanja Schwerdtle, Hajo Haase, Lutz Schomburg, Matthias B Schulze Eur J Nutr. 2021 Sep;60(6):3267-3278. doi: 10.1007/s00394-021-02494-3. Course and Survival of COVID-19 Patients with Comorbidities in Relation to the Trace Element Status at Hospital Admission Gijs Du Laing, Mirko Petrovic, Carl Lachat, Marthe De Boevre, Georg J Klingenberg, Qian Sun, Sarah De Saeger, Jozefien De Clercq, Louis Ide, Linos Vandekerckhove, Lutz Schomburg Nutrients. 2021 Sep 22;13(10):3304. doi: 10.3390/nu13103304. Positive effects of selenium supplementation in women with newly diagnosed Hashimoto’s thyroiditis in an area with low selenium status Jadwiga Kryczyk-Kozioł, Paweł Zagrodzki, Ewelina Prochownik, Anna Błażewska-Gruszczyk, Marian Słowiaczek, Qian Sun, Lutz Schomburg, Ewa Ochab, Mirosław Bartyzel Int J Clin Pract. 2021 Sep;75(9):e14484. doi: 10.1111/ijcp.14484. Clinical Significance of Micronutrient Supplementation in Critically Ill COVID-19 Patients with Severe ARDS Quirin Notz, Johannes Herrmann, Tobias Schlesinger, Philipp Helmer, Stephan Sudowe, Qian Sun, Julian Hackler, Daniel Roeder, Christopher Lotz, Patrick Meybohm, Peter Kranke, Lutz Schomburg, Christian Stoppe Nutrients. 2021 Jun 20;13(6):2113. doi: 10.3390/nu13062113. Predicting neurological recovery after traumatic spinal cord injury by time-resolved analysis of monocyte subsets Raban Arved Heller, Julian Seelig, Helena Lucia Crowell, Maximilian Pilz, Patrick Haubruck, Qian Sun, Lutz Schomburg, Volker Daniel, Arash Moghaddam, Bahram Biglari Brain. 2021 May 22;awab203. doi: 10.1093/brain/awab203. Effect of selenium supplementation on musculoskeletal health in older women: a randomised, double-blind, placebo-controlled trial Jennifer S Walsh, Richard M Jacques, Lutz Schomburg, Tom R Hill, John C Mathers, Graham R Williams, Richard Eastell Lancet Healthy Longev. 2021 Apr;2(4):e212-e221. doi: 10.1016/S2666-7568(21)00051-9. Serum Selenium Status as a Diagnostic Marker for the Prognosis of Liver Transplantation. Gül-Klein S, Haxhiraj D, Seelig J, Kästner A, Hackler J, Sun Q, Heller RA, Lachmann N, Pratschke J, Schmelzle M, Schomburg L. Nutrients. 2021 Feb 14;13(2):619. doi: 10.3390/nu13020619. Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker Raban Arved Heller, Qian Sun, Julian Hackler, Julian Seelig, Linda Seibert, Asan Cherkezov, Waldemar B Minich, Petra Seemann, Joachim Diegmann, Maximilian Pilz, Manuel Bachmann, Alireza Ranjbar, Arash Moghaddam, Lutz Schomburg Redox Biol. 2021 Jan;38:101764. doi: 10.1016/j.redox.2020.101764. 2020 Toenail selenium, plasma selenoprotein P and risk of advanced prostate cancer: a nested case-control study. Outzen M, Tjønneland A, Hughes DJ, Jenab M, Frederiksen K, Schomburg L, Morris S, Overvad K, Olsen A. Int J Cancer. 2020 Aug 24. doi: 10.1002/ijc.33267. Selenium Deficiency Is Associated with Mortality Risk from COVID-19. Moghaddam A, Heller RA, Sun Q, Seelig J, Cherkezov A, Seibert L, Hackler J, Seemann P, Diegmann J, Pilz M, Bachmann M, Minich WB, Schomburg L. Nutrients. 2020 Jul 16;12(7):2098. doi: 10.3390/nu12072098. Selenium and Copper as Biomarkers for Pulmonary Arterial Hypertension in Systemic Sclerosis. Sun Q, Hackler J, Hilger J, Gluschke H, Muric A, Simmons S, Schomburg L, Siegert E. Nutrients. 2020 Jun 25;12(6):1894. doi: 10.3390/nu12061894. Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite. Brodin O, Hackler J, Misra S, Wendt S, Sun Q, Laaf E, Stoppe C, Björnstedt M, Schomburg L. Nutrients. 2020 Apr 12;12(4):1067. doi: 10.3390/nu12041067. Cross-sectional analysis of trace element status in thyroid disease. Mehl S, Sun Q, Görlich CL, Hackler J, Kopp JF, Renko K, Mittag J, Schwerdtle T, Schomburg L. J Trace Elem Med Biol. 2020 Mar;58:126430. doi: 10.1016/j.jtemb.2019.126430. Copper and selenium status as biomarkers of neonatal infections. Hackler J, Wisniewska M, Greifenstein-Wiehe L, Minich WB, Cremer M, Bührer C, Schomburg L. J Trace Elem Med Biol. 2020 Mar;58:126437. doi: 10.1016/j.jtemb.2019.126437. Selenium and copper status – potential signposts for neurological remission after traumatic spinal cord injury. Seelig J, Heller RA, Hackler J, Haubruck P, Moghaddam A, Biglari B, Schomburg L. J Trace Elem Med Biol. 2020 Jan;57:126415. doi: 10.1016/j.jtemb.2019.126415. 2019 Selenoprotein P Deficiency and Risk of Mortality and Rehospitalization in Acute Heart Failure. Jujić A, Melander O, Bergmann A, Hartmann O, Nilsson PM, Bachus E, Struck J, Magnusson M. J Am Coll Cardiol. 2019 Aug 20;74(7):1009-1011. doi: 10.1016/j.jacc.2019.06.023. Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death. Schomburg L, Orho-Melander M, Struck J, Bergmann A, Melander O. Nutrients. 2019 Aug 9;11(8). pii: E1852. doi: 10.3390/nu11081852. Selenium and Selenoprotein P Deficiency Correlates with Complications and Adverse Outcome After Major Trauma. Braunstein M, Kusmenkov T, Zuck C, Angstwurm M, Becker NP, Böcker W, Schomburg L, Bogner-Flatz V. Shock. 2019 Apr 12. doi: 10.1097/SHK.0000000000001344. Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status. Fedirko V, Jenab M, Méplan C, Jones JS, Zhu W, Schomburg L, Siddiq A, Hybsier S, Overvad K, Tjønneland A, Omichessan H, Perduca V, Boutron-Ruault MC, Kühn T, Katzke V, Aleksandrova K, Trichopoulou A, Karakatsani A, Kotanidou A, Tumino R, Panico S, Masala G, Agnoli C, Naccarati A, Bueno-de-Mesquita B, Vermeulen RCH, Weiderpass E, Skeie G, Nøst TH, Lujan-Barroso L, Quirós JR, Huerta JM, Rodríguez-Barranco M, Barricarte A, Gylling B, Harlid S, Bradbury KE, Wareham N, Khaw KT, Gunter M, Murphy N, Freisling H, Tsilidis K, Aune D, Riboli E, Hesketh JE, Hughes DJ. Nutrients. 2019 Apr 25;11(4). pii: E935. doi: 10.3390/nu11040935. Letter by Schomburg and Melander Regarding Article, „Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target“. Schomburg L, Melander O. Circulation. 2019 Jan 29;139(5):722-723. doi: 10.1161/CIRCULATIONAHA.118.035782. Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease. Polyzos SA, Kountouras J, Mavrouli M, Katsinelos P, Doulberis M, Gavana E, Duntas L. Exp Clin Endocrinol Diabetes. 2019 Jan 9. doi: 10.1055/a-0811-9136. Relation of selenium status to neuro-regeneration after traumatic spinal cord injury. Heller RA, Seelig J, Bock T, Haubruck P, Grützner PA, Schomburg L, Moghaddam A, Biglari B. J Trace Elem Med Biol. 2019 Jan;51:141-149. doi: 10.1016/j.jtemb.2018.10.006. 2018 Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. Hughes DJ, Kunická T, Schomburg L, Liška V, Swan N, Souček P. Nutrients. 2018 Nov 21;10(11). pii: E1812. doi: 10.3390/nu10111812. Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits. Saito Y, Misu H, Takayama H, Takashima SI, Usui S, Takamura M, Kaneko S, Takamura T, Noguchi N. Biol Pharm Bull. 2018;41(5):828-832. doi: 10.1248/bpb.b18-00046. Cow Milk Consumption Increases Iodine Status in Women of Childbearing Age in a Randomized Controlled Trial. O’Kane SM, Pourshahidi LK, Mulhern MS, Strain JJ, Mackle EM, Koca D, Schomburg L, Hill S, O’Reilly J, Kmiotek D, Deitrich C, Bath SC, Yeates AJ. J Nutr. 2018 Mar 1;148(3):401-408. doi: 10.1093/jn/nxx043. 2017 Double-Blind, Placebo-Controlled, Randomized Trial of Selenium in Graves Hyperthyroidism. Kahaly GJ, Riedl M, König J, Diana T, Schomburg L. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4333-4341. doi: 10.1210/jc.2017-01736. Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P. Renko K, Martitz J, Hybsier S, Heynisch B, Voss L, Everley RA, Gygi SP, Stoedter M, Wisniewska M, Köhrle J, Gladyshev VN, Schomburg L. Sci Rep. 2017 Jun 29;7(1):4391. doi: 10.1038/s41598-017-04586-9. Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P. Hybsier S, Schulz T, Wu Z, Demuth I, Minich WB, Renko K, Rijntjes E, Köhrle J, Strasburger CJ, Steinhagen-Thiessen E, Schomburg L. Redox Biol. 2017 Apr;11:403-414. doi: 10.1016/j.redox.2016.12.025. 2016 Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Hughes DJ, Duarte-Salles T, Hybsier S, Trichopoulou A, Stepien M, Aleksandrova K, Overvad K, Tjønneland A, Olsen A, Affret A, Fagherazzi G, Boutron-Ruault MC, Katzke V, Kaaks R, Boeing H, Bamia C, Lagiou P, Peppa E, Palli D, Krogh V, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, Peeters PH, Engeset D, Weiderpass E, Lasheras C, Agudo A, Sánchez MJ, Navarro C, Ardanaz E, Dorronsoro M, Hemmingsson O, Wareham NJ, Khaw KT, Bradbury KE, Cross AJ, Gunter M, Riboli E, Romieu I, Schomburg L, Jenab M. Am J Clin Nutr. 2016 Aug;104(2):406-14. doi: 10.3945/ajcn.116.131672. Selenium status in neonates with connatal infection. Wiehe L, Cremer M, Wisniewska M, Becker NP, Rijntjes E, Martitz J, Hybsier S, Renko K, Bührer C, Schomburg L. Br J Nutr. 2016 Aug;116(3):504-13. doi: 10.1017/S0007114516002208. Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men. Beukhof CM, Medici M, van den Beld AW, Hollenbach B, Hoeg A, Visser WE, de Herder WW, Visser TJ, Schomburg L, Peeters RP. PLoS One. 2016 Apr 7;11(4):e0152748. doi: 10.1371/journal.pone.0152748. Lack of Association between Selenium Status and Disease Severity and Activity in Patients with Graves‘ Ophthalmopathy. Dehina N, Hofmann PJ, Behrends T, Eckstein A, Schomburg L. Eur Thyroid J. 2016 Mar;5(1):57-64. doi: 10.1159/000442440. 2015 Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. Hughes DJ, Fedirko V, Jenab M, Schomburg L, Méplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjønneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kühn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters PH, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sánchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quirós JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE. Int J Cancer. 2015 Mar 1;136(5):1149-61. doi: 10.1002/ijc.29071. Chronic Kidney Disease Distinctly Affects Relationship Between Selenoprotein P Status and Serum Thyroid Hormone Parameters. Reinhardt W, Dolff S, Benson S, Broecker-Preuß M, Behrendt S, Hög A, Führer D, Schomburg L, Köhrle J. Thyroid. 2015 Oct;25(10):1091-6. doi: 10.1089/thy.2015.0097. Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine. Turanov AA, Everley RA, Hybsier S, Renko K, Schomburg L, Gygi SP, Hatfield DL, Gladyshev VN. PLoS One. 2015 Oct 9;10(10):e0140353. doi: 10.1371/journal.pone.0140353. Association between maternal micronutrient status, oxidative stress, and common genetic variants in antioxidant enzymes at 15 weeks׳ gestation in nulliparous women who subsequently develop preeclampsia. Mistry HD, Gill CA, Kurlak LO, Seed PT, Hesketh JE, Méplan C, Schomburg L, Chappell LC, Morgan L, Poston L; SCOPE Consortium. Free Radic Biol Med. 2015 Jan;78:147-55. doi: 10.1016/j.freeradbiomed.2014.10.580. Gene-specific regulation of hepatic selenoprotein expression by interleukin-6. Martitz J, Becker NP, Renko K, Stoedter M, Hybsier S, Schomburg L. Metallomics. 2015 Nov;7(11):1515-21. doi: 10.1039/c5mt00211g. 2014 Selenoprotein P is the essential selenium transporter for bones. Pietschmann N, Rijntjes E, Hoeg A, Stoedter M, Schweizer U, Seemann P, Schomburg L. Metallomics. 2014 May;6(5):1043-9. doi: 10.1039/c4mt00003j. Selenite supplementation in euthyroid subjects with thyroid peroxidase antibodies. Eskes SA, Endert E, Fliers E, Birnie E, Hollenbach B, Schomburg L, Köhrle J, Wiersinga WM. Clin Endocrinol (Oxf). 2014 Mar;80(3):444-51. doi: 10.1111/cen.12284. Selenoprotein P in seminal fluid is a novel biomarker of sperm quality. Michaelis M, Gralla O, Behrends T, Scharpf M, Endermann T, Rijntjes E, Pietschmann N, Hollenbach B, Schomburg L. Biochem Biophys Res Commun. 2014 Jan 17;443(3):905-10. doi: 10.1016/j.bbrc.2013.12.067. Hypoxia reduces and redirects selenoprotein biosynthesis. Becker NP, Martitz J, Renko K, Stoedter M, Hybsier S, Cramer T, Schomburg L.Metallomics. 2014 May;6(5):1079-86. doi: 10.1039/c4mt00004h. 2012 Differential responses to selenomethionine supplementation by sex and genotype in healthy adults. Combs GF Jr, Jackson MI, Watts JC, Johnson LK, Zeng H, Idso J, Schomburg L, Hoeg A, Hoefig CS, Chiang EC, Waters DJ, Davis CD, Milner JA. Br J Nutr. 2012 May;107(10):1514-25. doi: 10.1017/S0007114511004715. Selenoprotein P status correlates to cancer-specific mortality in renal cancer patients. Meyer HA, Endermann T, Stephan C, Stoedter M, Behrends T, Wolff I, Jung K, Schomburg L. PLoS One. 2012;7(10):e46644. doi: 10.1371/journal.pone.0046644. Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women. Hoeg A, Gogakos A, Murphy E, Mueller S, Köhrle J, Reid DM, Glüer CC, Felsenberg D, Roux C, Eastell R, Schomburg L, Williams GR. J Clin Endocrinol Metab. 2012 Nov;97(11):4061-70. doi: 10.1210/jc.2012-2121. 2011 Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture. Hoefig CS, Renko K, Köhrle J, Birringer M, Schomburg L. J Nutr Biochem. 2011 Oct;22(10):945-55. doi: 10.1016/j.jnutbio.2010.08.006. Determinants of selenium status in healthy adults. Combs GF Jr, Watts JC, Jackson MI, Johnson LK, Zeng H, Scheett AJ, Uthus EO, Schomburg L, Hoeg A, Hoefig CS, Davis CD, Milner JA. Nutr J. 2011 Jul 18;10:75. doi: 10.1186/1475-2891-10-75. 2010 Selenoprotein-related disease in a young girl caused by nonsense mutations in the SBP2 gene. Azevedo MF, Barra GB, Naves LA, Ribeiro Velasco LF, Godoy Garcia Castro P, de Castro LC, Amato AA, Miniard A, Driscoll D, Schomburg L, de Assis Rocha Neves F. J Clin Endocrinol Metab. 2010 Aug;95(8):4066-71. doi: 10.1210/jc.2009-2611. The choice of biomarkers determines the selenium status in young German vegans and vegetarians. Hoeflich J, Hollenbach B, Behrends T, Hoeg A, Stosnach H, Schomburg L. Br J Nutr. 2010 Dec;104(11):1601-4. doi: 10.1017/S0007114510002618. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men. Steinbrecher A, Méplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, Akesson B, Rohrmann S, Linseisen J. Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2958-68. doi: 10.1158/1055-9965.EPI-10-0364. 2009 Reduced serum selenoprotein P concentrations in German prostate cancer patients. Meyer HA, Hollenbach B, Stephan C, Endermann T, Morgenthaler NG, Cammann H, Köhrle J, Jung K, Schomburg L. Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2386-90. doi: 10.1158/1055-9965.EPI-09-0262. Serum selenium and selenoprotein P status in adult Danes – 8-year followup. Rasmussen LB, Hollenbach B, Laurberg P, Carlé A, Hög A, Jørgensen T, Vejbjerg P, Ovesen L, Schomburg L. J Trace Elem Med Biol. 2009;23(4):265-71. doi: 10.1016/j.jtemb.2009.03.009. Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice. Renko K, Hofmann PJ, Stoedter M, Hollenbach B, Behrends T, Köhrle J, Schweizer U, Schomburg L. FASEB J. 2009 Jun;23(6):1758-65. doi: 10.1096/fj.08-119370. Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations. Schomburg L, Dumitrescu AM, Liao XH, Bin-Abbas B, Hoeflich J, Köhrle J, Refetoff S. Thyroid. 2009 Mar;19(3):277-81. doi: 10.1089/thy.2008.0397. 2008 Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice. Renko K, Werner M, Renner-Müller I, Cooper TG, Yeung CH, Hollenbach B, Scharpf M, Köhrle J, Schomburg L, Schweizer U. Biochem J. 2008 Feb 1;409(3):741-9. New assay for the measurement of selenoprotein P as a sepsis biomarker from serum. Hollenbach B, Morgenthaler NG, Struck J, Alonso C, Bergmann A, Köhrle J, Schomburg L. J Trace Elem Med Biol. 2008;22(1):24-32. doi: 10.1016/j.jtemb.2007.11.003. Twitter LinkedIn Facebook Datenschutz Impressum AGB © selenOmed GmbH 2021