ABOUT US SCIENCE PIPELINE PATIENTS & CAREGIVERS INVESTORS/MEDIA INSIDE SIGILON Lysosomal Diseases Lysosomal diseases are a group of rare, genetic metabolic diseases in which cellular waste products build up in the body. These disorders are generally progressive and there is no cure. Many lysosomal diseases have no FDA-approved treatment. As a patient or caregiver, you or your loved one faces an array of challenges. You may be living with many different clinical presentations and disabilities, uncertainty about the future course of your disease, or have significant medical expenses. Even when available, lysosomal disease therapies may have limited efficacy and require regular intravenous infusions. We empathize with you. Our Shielded Living Therapeutics™ platform has the potential to provide durable, consistent delivery of enzymes for the treatment of MPS-1 or Fabry Disease. Clinical Trials MPS-1 & Fabry: Information on these potential clinical trials will be updated once available. Patient Resources North America Canadian MPS Society Courageous Parents Network Fabry Support & Information Group National MPS Society National Fabry Disease Foundation NORD International Casa Hunter Fabry Network MPS Society Vidas Raras BACK TO PATIENTS & CAREGIVER OVERVIEW ©2021 Sigilon Therapeutics, Inc. The marks SIGILON THERAPEUTICS, SIGILON, SHIELDED LIVING THERAPEUTICS, SLTX, AFIBROMER, AFIBROTEK, and our logos are trademarks of Sigilon Therapeutics, Inc. in the U.S. and other countries. All other marks are the property of their respective owners. Privacy Policy

ABOUT US SCIENCE PIPELINE PATIENTS & CAREGIVERS INVESTORS/MEDIA INSIDE SIGILON Headquarters Sigilon Therapeutics, Inc. 100 Binney St, STE 600 Cambridge, MA 02142 617-336-7540 info@sigilon.com Media Contact Brandon Hagen Communications Manager brandon.hagen@sigilon.com ©2021 Sigilon Therapeutics, Inc. The marks SIGILON THERAPEUTICS, SIGILON, SHIELDED LIVING THERAPEUTICS, SLTX, AFIBROMER, AFIBROTEK, and our logos are trademarks of Sigilon Therapeutics, Inc. in the U.S. and other countries. All other marks are the property of their respective owners. Privacy Policy