DRUG DISCOVERY UNLEASHED CETSA® by Pelago Bioscience The Cellular Thermal Shift Assay (CETSA® by Pelago Bioscience) has multiple assay formats that make it a keystone of decision making throughout the drug discovery pipeline. Unlike other solutions on the market today, its unique approach allows the assessment and quantification of target engagement under physiological conditions – without the need to modify the compound or protein. This provides data that is both actionable and biologically relevant. Think of CETSA® as snapshots of true target engagement inside the cell, any time you need them. Learn more HOW DO I KNOW IF MY COMPOUND WILL BE EFFECTIVE? VISIT PELAGO KNOWLEDGE CENTER A WIDE RANGE OF SERVICES FROM EARLY DISCOVERY TO CONFIRMATION Our CETSA® teams offer a range of customized services, designed to help you make better decisions faster, no matter where you are in the drug discovery process. True target engagement assessment TARGET IDENTIFICATION LEAD GENERATION LEAD OPTIMIZATION PRECLINICAL STUDIES CLINICAL TRIALS APPROVED DRUGS MORE ABOUT OUR OFFERINGS Technology One proven assay. Many flexible formats. The Cellular Thermal Shift Assay (CETSA®) is a well-established, proven and accurate technique for measuring compound binding to target proteins. While CETSA® can be adapted for different applications to support any stage of the drug discovery process – from low-throughput confirmation and medium-throughput discovery to proteome-wide exploration – these different methods all rely on the same principle: measurements of the ‘thermal shift’ that occurs when a ligand interacts with a protein. LEARN ABOUT THE CETSA ® TECHNOLOGY When a compound binds to a protein, the denaturation temperature of that protein can be altered. By applying heat shocks to cells or tissue, then quantifying the difference in the amount of soluble protein in presence compared to absence of the compound, we are able to create snapshots of target engagement under actual physiological conditions. This is how CETSA® can be used to assess and quantify compound-protein interactions. “At AstraZeneca we are applying CETSA® HT in high-throughput screening and lead optimization to identify and characterize hit and lead compounds for a number of novel targets.” Thomas Lundbäck, Associate Director, AstraZeneca, ”CETSA® data is a keystone in our SAR analysis, and by assessing cellular engagement of our compounds across multiple cell lines we gain confidence in our project prioritizations.” Peter Joyce, CEO & co-founder, Grey Wolf Therapeutics ”Chemoproteomics is like taking a watch to pieces and counting the cogs—it doesn’t tell you which cogs drive which process and how the wider system works. This is why using CETSA® MS can add so much value to your target identification studies” Pär Nordlund, Professor & inventor of CETSA® Karolinska Institute About Pelago ” Using our world leading expertise in CETSA® we have created a faster and more efficient drug discovery process. We take great pride in knowing our customers are bringing new medicines to market more quickly thanks to our help. Michael Dabrowski CEO, Pelago Bioscience ABOUT PELAGO Speak to our experts Learn how CETSA® can enable your project by talking to one of our Drug Discovery experts. CONTACT US Latest news June 17, 2021 Webinar DTR The Cellular Thermal Shift Assay (CETSA®) is an easy and proven method to demonstrate ligand-protein interactions in living cells and can be used without the need of any modifications to the ligand or protein. Quantification methods like PerkinElmer’s no-wash immunoassays… May 20, 2021 Pelago Bioscience is featured in Drug Discovery World, spring edition 2021. CETSA® by Pelago can be adapted for different applications to support any stage of the drug discovery process from low-throughput confirmation and high-throughput discovery to proteome-wide exploration – these methods rely on the same principle: measurements of the ‘thermal shift�… April 8, 2021 Press Release – New Facility Pelago Bioscience AB expands to new facility After several years of continued growth in our current facilities Pelago Bioscience now really expands. The new building is located at Campus Solna, a rapidly developing Life Science cluster located in central… February 24, 2021 April 7 Webinar Confirmation of target engagement in relevant physiological environment ensures successful drug discovery and the right project prioritization. By applying CETSA®, you can make better and more informed decisions at earlier stages in your drug discovery projects. Welcome to learn from… November 13, 2020 Gasell prize to Pelago-again Time to celebrate – For the third year in a row, Pelago has been awarded the prestigious DI Gasell prize by the Swedish daily business newspaper Dagens Industri. This prize recognizes the fastest growing Swedish companies, with less than 1… October 21, 2020 Pelago receives CIR (French Research Tax Credit) accreditation We have the pleasure to announce that the French Ministry for Higher Education and Research has recognised Pelago Bioscience AB as an approved research and development service provider. This allows companies, subject to the French General Tax Code, to take… May 11, 2020 New interesting CETSA® paper in Nature protocols Don’t miss this new interesting CETSA® paper published in Nature Protocols. https://www.nature.com/articles/s41596-020-0310-z Are you sure? Is you target compound really theraputic? Speak to our experts Learn how CETSA® can enable your project by talking to one of our Drug Discovery… MORE NEWS Meet us on LinkedIn 2d Today the Swedish Chamber of Commerce announced the most prominent Engineering Technologist of 2021, Pelago Bioscience co-founder and CSO Daniel Martinez Molina for his work on the Cellular Thermal Shift Assay (CETSA®). “CETSA® makes it possible to be more proactive, we enable our customers to take more confident decisions, earlier in the drug discovery process. We also work with further development, to reach a point where we can predict what adverse effects a patient will have from a drug, instead of finding out after the fact” – Daniel Martinez Molina (Article in Swedish) https://lnkd.in/eKJMHnr8 22d Are you planning to attend Oxford Global Biomarkers UK conference next week? Then you should definitely check out our Presentation by @Daniel Martinez Molina. He will talk about how CETSA® can be used in Biomarker Discovery. Hope to see you in Manchester on November 8/9! @Oxford Global Conferences #pelagobio #cetsa #drugdiscovery #sciencewithengagement 10d Webinar tomorrow! Last call to register for our webinar organized together with Grey Wolf Therapeutics and Sygnature Discovery. Register today and don't miss dr Peter Joyce and dr Juliet Morgan presenting about CETSA® applications in a pre-clinical context! Register here: https://lnkd.in/dnTEH_Yk Watch the previous presentations on demand https://lnkd.in/ewCD_XWk https://lnkd.in/dzGMPizw #pelagobio #Sciencewithengagement #webinar 24d Are you interested in pre-clinical studies in cancer treatment? Learn more from a presentation by dr Peter Joyce (Grey Wolf Therapeutics) and dr Juliet Morgan (Sygnature Discovery) in the third event of Pelago webinar series. Register here before November 17: https://lnkd.in/dnTEH_Yk Watch the previous presentations on demand https://lnkd.in/ewCD_XWk https://lnkd.in/dzGMPizw #pelagobio #Sciencewithengagement #webinar 16d Next week Pelago Bioscience together with Grey Wolf Therapeutics and Sygnature Discovery will hold a third webinar around CETSA® technology, this time in a pre-clinical context. Register today and don't miss presentations by dr Peter Joyce and dr Juliet Morgan! Register here before November 17: https://lnkd.in/dnTEH_Yk Watch the previous presentations on demand https://lnkd.in/ewCD_XWk https://lnkd.in/dzGMPizw #pelagobio #Sciencewithengagement #webinar 26d Exciting opportunities are opening up at Pelago Bioscience! We are looking for two Project Advisors and Sales & Marketing Coordinator, working together with a dedicated team to unleash drug discovery. Read more about the open positions on our website: https://lnkd.in/e-MJuGeX #pelagobio #sciencewithengagement #cetsa #drugdiscovery LOAD MORE Want to work at Pelago? We take pride in being experts in our field, and by staying curious we constantly strive to improve. We have a strong foundation based on trust in each other, and by being good team members we build our relationships and collaborations. CAREERS BOOK A MEETING Pelago Bioscience AB Banvaktsvägen 20 171 48 Solna Sweden Contact us Privacy Policy We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept”, you consent to the use of ALL the cookies. Pelago Cookies Policy Cookie settings Accept