Why Persona Explore Sign In What are DNIs? "Prescription medications may change the way the body absorbs or utilizes certain micronutrients, raising overall levels, especially if the person is also supplementing with a daily vitamin. And, on the flip side, the daily vitamin, herb or other supplement may impact the effectiveness of the medication. These are called drug-nutrient interactions (DNIs)." — Brandi Cole, PharmD, pharmacist at Persona Nutrition Explore the Database Drug-nutrient interaction database Enter a medication or over-the-counter product you are taking to check for interactions with Persona vitamins or supplements. Can't find your medication? call, chat, or email our team of nutritionists for further assistance. Add Another Check drug-nutrient interactions Common Drug Interactions Our team has developed a database of over 3,000 drugs that interact with nutritional supplements. Below we highlight the top eight, based on customer input. Immunity High Blood Pressure Mood Blood Thinning Birth Control Immunosuppressant Cholesterol Diabetes Thyroid Immunity Zinc When taken simultaneously with some medications, zinc can bind with the drug in the stomach and form complexes making it more difficult for the body to absorb the medication. This is a common interaction with thyroid medications and certain types of antibiotics. Vitamin C Vitamin C may increase estrogen levels by altering the way they body metabolizes the hormone. This can increase the side effects a patient may experience in particular with hormone replacement therapy or oral contraceptives containing estrogen. Immunosuppressive Therapy Patient's using immunosuppressive therapies should consult their health care provider prior to taking any supplement that may stimulate their immune system. High Blood Pressure Antihypertensives + Garlic For those taking antihypertensives, garlic supplements may have an additive effect with these prescription drugs and should be avoided. Diuretics + Fish Oil Because diuretics can decrease blood pressure, when combined with supplements that may also lower blood pressure, diuretics could potentially increase risk for hypotension. Mood Antidepressants + 5-HTP 5-HTP is a precursor of serotonin. Combining supplemental 5-HTP with antidepressant medications that increase serotonin levels in the brain could theoretically lead to serotonin syndrome, a dangerous overload of serotonin in the brain. Common side effects of serotonin syndrome include headache, confusion, and loss of muscle coordination, but in severe cases result in irregular heart rhythm or seizure. Anxiety Medications + Grapefruit Grapefruit can interfere with certain antianxiety medications by altering enzymes responsible for transporting these medications into the blood stream and the breakdown of these medications. This results in increased side effects of antianxiety medications, like prolonged sedation. Grapefruit should be avoided with antianxiety medications to ensure appropriate levels of medications in the blood stream. Blood Thinning Warfarin + Vitamin K Vitamin K is an essential vitamin to promote normal amounts of blood clotting in the body and preventing excessive bleeding. However, when combined, vitamin K can work against these anticoagulant medications and increase the risk for a blood clot. Birth Control Oral Contraceptives + Green Tea Extract Certain oral contraceptives can decrease caffeine clearance in the body by up to 65%, which can increase the effects of caffeine in green tea. Oral Contraceptives + Garlic Garlic should be avoided with oral contraceptives to ensure the drug is not cleared too quickly from the body, and potentially make the medication less effective. Immunosuppresant Immunosuppresant Therapy + Spirulina Spirulina is thought to stimulate the body's immune system. Immunosuppressant therapies, commonly used to treat Crohn's disease and psoriasis, can be less effective if the body's immune system is activated. Cholesterol Statins + CoQ10 Cholesterol lowering medications, called statins, block your body from producing cholesterol. It is thought that using a CoEnzyme Q10 supplement may help relieve muscle discomfort in patients taking a statin therapy. Diabetes Anidiabetic Medications + Ashwagandha Preliminary evidence shows that ashwagandha root powder can decrease blood glucose. To avoid an additive effect of blood sugar becoming too low, Ashwagandha should be avoided with those taking blood sugar lowering drugs. Thyroid Thyroid Medications + Iron When taken simultaneously, thyroid medications and iron form insoluble complexes in the gastrointestinal tract preventing the absorption of thyroid medication into the blood stream. Iron supplements should be taken at least two hours apart from thyroid medications to ensure complete absorption of the drug. Speak with your doctor, pharmacist, or nutritionist to better understand any possible DNIs prior to starting a new medication or nutritional supplement program. What Our Customers Say About Us Help is at Your Fingertips Chat Call Email Our on-staff nutritionists are here to answer your questions. 7 Days a Week, 5:00 AM to 6:00 PM PST. For more help, take a look at our FAQ below. Choose your cookie settings We use two types of cookies: ‘Necessary’ cookies, which keep our site working, and optional ‘analytics’ cookies, which remember your preferences to improve your experience. You can disable analytics cookies using the ‘settings’ link below. 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