Careers Investors Sustainability Contact Vlog Sign In EN TECHNOLOGIES APPLICATIONS RESOURCES SHOP COMPANY Chromatography Systems Artesyn® Chromatography Systems offer optimized flow paths with injection-molded and overmolded connections and signature valve blocks that significantly reduce deviations and produce higher product yields. REQUEST A QUOTE WEBINAR IMPROVE YIELD, SIMPLIFY OPERATION Multiple Repligen-exclusive hardware and flow path innovations deliver increased product yield and operational success. Expert engineering minimizes product loss, enabling batch changes under 30 minutes while increasing yield and productivity. Systems seamlessly scale from 1/4” - 1” internal diameter (ID) tubing. Connectivity supports all major column formats, including full compatibility with OPUS® Pre-packed Columns. Components Multi-valve block arrays 4-chamber diaphragm pumps Non-product contact ultrasonic flow meters Non-product contact pressure transmitters HMI, touch screen and glass keyboard Non-product contact liquid level switch Multi-sensor OPTEK® converter (UV, pH, conductivity) Column manifold OPTIMAL PROCESS YIELD Reduce hold-up volume with synergistic flow path and hardware OPUS® COMPATIBLE Connect seamlessly with OPUS® Pre-packed Columns OPERATIONAL SIMPLICITY Execute more runs with batch change overs under 30 min SCALE-UP CHROMATOGRAPHY Systems scale from 1/4” to 1” flow path ID to support flow rates from 1 - 3000 LPH and OPUS® 8-80R Pre-packed Chromatography Columns. Consistent engineering and design across the platform facilitates scale-up development studies and technical transfer. Scale from 1/4" - 1" ID while maintaining system architecture and control platform Implement off-the-shelf systems for fast lead times 1/4" System 1/2" System System Flow Rate 1 - 180 L/H 6 - 1000 L/H Column ID 8 - 25 cm 20 - 45 cm INNOVATIVE DESIGN AND ENGINEERING INCREASE YIELD AND MITIGATE DEVIATIONS Feature Benefit Proprietary valve blocks Minimize dead legs and hold-up volume (< 2D) Over-molded connections Reduce shear stress with constant bore ID, minimize leaks risk and process related impurities Chromatography-specific valve manifolds Maximize process yield with < 50% fill volume for precision gradient control Filter-based air trap Reduce hold-up volume with bubble trap alternative Diaphragm pump Lower shear stress, increase maximum pressure, redeuced pulsation Full OPUS® Pre-packed Column compatibility Accelerate implementation wtih plug-and-play columns: 10 cm - 80 cm internal diameters CHANGE BATCHES FASTER AND REDUCE LEAKS WITH INJECTION-MOLDED FLOW PATHS Pre-assembled chromatography flow paths integrate advanced fluid management technologies, including injection molding, over-molded connections, pump heads, tubing, filters and sensors in a strong, nearly leak-free, closed and single-use device. Designed for simplicity, flow paths install in less than 30 minutes and increase process efficiency. Components Inlet ports Pump head Over-molded connection Filter-based air trap Column ports In-line sensors Outlet ports REDUCE HOLD UP VOLUME WITH SYNERGISTIC VALVE AND FLOW PATH TECHNOLOGY Valve Block Components Pneumatic actuators Manifold closure points Overmolded joints with sterile connectors Molded single-use flow path Innovative valve blocks direct fluids through uniform ID, crevice-free flow paths, achieving extremely low turbulence. Multiple T injection-molded silicone inserts, combined with over-molded connections, minimize footprint and enable optimum closure point placement, significantly reducing dead leg. Traditional hose-barbed manifold Multiple ID variations promote turbulence Hose-barb connections foster leaks Large dead legs increase hold-up volume, turbulent flow Manifold batch-to-batch dimensional differrences create process variations Artesyn® molded manifold Uniform, crevice free ID minimizes turbulence Over-molded connections reduce leaks Minimal dead leg improves drainability and reduces hold-up volume injection-molded flow paths enable batch-to-batch dimensional and process consistency RESOURCES EXPAND ALL System Specifications Data Sheet Webinar © Copyright 2021 Repligen Corporation. All rights reserved. Contact Privacy Policy Legal Careers HOME TECHNOLOGIES APPLICATIONS RESOURCES SHOP COMPANY ACCOUNT CAREERS INVESTORS SUSTAINABILITY CONTACT VLOG SIGN IN PROFILE SIGN OUT SELECT LANGUAGE Cookie Control Your choice regarding cookies on this site We use cookies to optimize site functionality and give you the best possible experience. I AcceptI Do Not AcceptSettings