FR EN MAIN NAVIGATION COMPANY SCIENCE PRODUCTS PARTNERING INVESTORS MEDIA CAREERS MONALIZUMAB PARTENERED WITH ASTRAZENECA | PHASE 3 | HEAD AND NECK CANCER Home Products Monalizumab Monalizumab (IPH2201) is a potentially first-in-class immune checkpoint inhibitor targeting NKG2A receptors expressed on tumor infiltrating cytotoxic CD8+ T cells and NK cells. NKG2A is an inhibitory checkpoint receptor for HLA-E. By expressing HLA-E, cancer cells can protect themselves from killing by NKG2A+ immune cells. HLA-E is frequently overexpressed on cancer cells of many solid tumors and hematological malignancies. Monalizumab may re-establish a broad anti-tumor response mediated by NK and T cells, and may enhance the cytotoxic potential of other therapeutic antibodies (André et al, Cell 2018). Mechanism of action Monalizumab is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. By acting simultaneously on innate and adaptive immunity, monalizumab may re-establish a broad anti-tumor response. Clinical development Partnership with AstraZeneca Publications, posters and presentations View publications Main menu Pipeline overview Clinical trials ------------------ Lacutamab Monalizumab Avdoralimab IPH5201 IPH5301 IPH6101 IPH62 LATEST NEWS ON MONALIZUMAB Innate Pharma Third Quarter 2021 Report November 16, 2021 Monalizumab data from COAST trial presented at ESMO Congress 2021 September 17, 2021 Innate Pharma Reports First Half 2021 Financial Results and Business Update September 15, 2021 All press releases Footer Contact Location Legal Info Terms of use Privacy Notice Cookies notice General Conditions of Purchase Search Search Follow us Stay in touch Subscribe to our newsletter Contact us Location 117, Avenue de Luminy - BP 30191 13 009 Marseille FRANCE +33 (0)4 30 30 30 30 Innate Pharma, Inc. 2273 Research Boulevard, Suite 350 Rockville, MD 20850, USA

FR EN MAIN NAVIGATION COMPANY SCIENCE PRODUCTS PARTNERING INVESTORS MEDIA CAREERS Home Location LOCATION Footer Contact Location Legal Info Terms of use Privacy Notice Cookies notice General Conditions of Purchase Search Search Follow us Stay in touch Subscribe to our newsletter Contact us Location 117, Avenue de Luminy - BP 30191 13 009 Marseille FRANCE +33 (0)4 30 30 30 30 Innate Pharma, Inc. 2273 Research Boulevard, Suite 350 Rockville, MD 20850, USA