About Leadership Technology Investors Pipeline News Careers and Culture Contact Us Changing the future of Oncology. Bispecific and Engineered Antibodies Sutro’s cell-free expression technology provides a rapid and powerful platform for the discovery and development of antibodies that bind simultaneously to two separate antigens (bispecific antibodies). Bispecific antibodies can be designed to achieve different purposes: Video Player While many different bispecific antibody formats have been exemplified using cell-based expression systems, and some have been successful enough to show promise as new therapeutics, the precise geometry and spatial orientation of binding domains, linkers and functional domains can be a challenge to optimize. Additionally, the use of cell-based systems has revealed immense difficulties in expressing bispecific antibodies, particularly at larger scale, often resulting in poorly folded and aggregated material. Consequently, using traditional cell-based technologies prevents researchers from discovering and developing bispecific candidates with optimal therapeutic indices and can result in products with unpredictable pharmacokinetic properties, stability and efficacy. Sutro’s technology has the ability to perform rapid expression and characterization of many variants early in discovery to define structure-activity relationships and thereby optimize: Video Player Sutro can rapidly screen candidates to identify molecules with the best overall combination of these properties resulting in optimized product candidates. 0 1 SUTRO BIOPHARMA 111 OYSTER POINT BLVD SOUTH SAN FRANCISCO, CA 94080 PHONE: 650-881-6500 FAX: 650-553-9659 GOOGLE MAP CONTACT US GENERAL INQUIRES: GENERAL@SUTROBIO.COM BUSINESS INQUIRES: BUSDEV@SUTROBIO.COM INVESTOR RELATIONS INQUIRES: IR@SUTROBIO.COM CAREERS: JOBS@SUTROBIO.COM © 2021 Sutro Biopharma, Inc. – Privacy Policy

About Leadership Technology Investors Pipeline News Careers and Culture Contact Us Changing the future of Oncology. Piper Sandler 33rd Annual Healthcare Conference – Presentation Nov 22, 2021 Webcast, Nov 22, 2021 at 10:00am EST Download Presentation, Click here SUTRO BIOPHARMA 111 OYSTER POINT BLVD SOUTH SAN FRANCISCO, CA 94080 PHONE: 650-881-6500 FAX: 650-553-9659 GOOGLE MAP CONTACT US GENERAL INQUIRES: GENERAL@SUTROBIO.COM BUSINESS INQUIRES: BUSDEV@SUTROBIO.COM INVESTOR RELATIONS INQUIRES: IR@SUTROBIO.COM CAREERS: JOBS@SUTROBIO.COM © 2021 Sutro Biopharma, Inc. – Privacy Policy