Peyronie's Disease Peyronie’s is a condition that occurs upon penile tissue disruption often caused by sexual activity or injury, healing into predominantly collagen-based scars that may ultimately harden and cause penile deformity, primarily seen as penile curvature. There are two main phases to Peyronie’s disease, Acute and Chronic. 01 ACUTE PHASE In the Acute phase of Peyronie’s disease, the disrupted or injured penile tissue is painful to varying degrees, sexual engagement may be painful and there may be early signs of erectile curvature or unusual erectile shaping and nodules (knots, lumps or bumps) under the penile skin may be felt with or without an erection. This Acute phase is often anticipated to occur for about 12-18 months prior to the Chronic phase. 02 CHRONIC PHASE In the Chronic phase of Peyronie’s disease, the penile tissue disruption or injury becomes less painful or not painful at all, however, the nodules (knots, lumps or bumps) become more palpable (plain to feel and detect) and the erectile curvature or erectile shape abnormality becomes potentially more obvious or worsened. In the Chronic phase, the disrupted or injured penile tissue may continue to progress into more rigid scarring, also often known as calcification. Whether in the Acute phase or Chronic phase, it is worth making an appointment with your Urologist and examining your specific presentation and treatment plan. Peyronie’s disease was first identified in the 1500s and later officially known after Francois Gigot de lay Peyronie, a French surgeon, formalized it as a medical condition impacting men and erectile function. Peyronie’s disease has a long history, but only recently has gained greater awareness. Your Urologist is likely to have significant resources to help treat and educate you on this condition. Don’t wait, and don’t hesitate, see your Healthcare Practitioner if you are impacted by the features and descriptions on this page. For additional info read more about Peyronie’s disease on the National Institute of Diabetes and Digestive and Kidney Diseases website. Learn More About Learn Science Investors Terms of Use Privacy Policy California Compliance Careers © 2020 Metuchen. All Rights Reserved.