Apply for funding Close Home For Researchers and Professionals For Families Living With PHTS About PTEN Research Apply for funding » Our research Supporting research that will help develop treatments for PHTS We fund scientific and medical research that we hope will result in the development of therapy options for adults and children with PHTS within the next 10 years. The pursuit of this goal should also lead to improvements in the care of people with PHTS. This is a significant task but we are not starting at beginning. As well as being involved in PHTS, PTEN, and other genes like it, are often altered in cancers that spontaneously arise. Since the discovery of PTEN 20 years ago, scientists have gained a great deal of knowledge about how these genes work in cells and tissues, which is helpful for those researching PHTS. As well as drawing on existing knowledge about how PTEN works, we can also draw on existing knowledge about PHTS. People directly affected by PHTS are experts on the condition and help us understand what would make the most difference to their lives. Developing new medicines is a long and complicated process. It starts with research designed to understand exactly what causes the condition, so that medicine candidates which target the cause can be identified. It finishes with large scale clinical trials in people with the condition to show that a new medicine is effective and safe enough to be prescribed by doctors. Find out more about how new medicines are developed here. The research we fund covers this whole process. Supported projects include both the discovery of completely new potential medicines for PHTS, and finding out if existing medicines, already used to treat other conditions, might also help people with PHTS. What types of research are funded? Our current and planned research projects include: 1. Observational studies of people with PHTS These studies recruit volunteers with PHTS, and record both what happened in their past and then follow them up over time. The information collected is analysed to better understand how PHTS-related symptoms change over time in different people. These are sometimes described as natural history studies. Find out here how one of our projects is studying cancer outcomes in a large group of people with PHTS Find out here how another is studying people in the UK who have PHTS. 2. Basic research into how the PTEN gene mutation causes PHTS 3. Models for pre-clinical testing of potential PHTS medicines. 4. Exploring whether existing medicines may help treat PHTS 5. Preparing for future clinical trials 6. Optimising how people with PHTS are being treated now How are research projects chosen? We invite researchers to send us proposals for PHTS research projects in two different ways: They can send us proposals that match up with one or more parts of our general research priorities, as outlined above. From time to time, we may request proposals on a specific research topic that we feel is important to prioritise. This second approach is referred to as “Targeted Calls”. All research proposals are reviewed in detail by external experts in the field of the proposed research project, and our Scientific Advisory Board, which includes experts in PHTS basic and clinical research, and in medicines development. Only the projects these experts feel meet our requirements will be recommended for funding. Ultimately, our Trustees, who are responsible for ensuring that PTEN Research charity funding is used responsibly, have the final say on what is funded and what is not. Information for Families Living With PHTS Our research Case study: Cancer outcomes Case study: Searching the genome Case study: UK PHTS patient registry Case study: Clinical trials of existing medications How are new medicines developed? Use of animals in research Learn more. Accept cookies For Researchers and Professionals Apply for research funding Targeted calls PHTS and the PTEN Gene Research strategy Projects and publications Partner with us For Families Living With PHTS About PHTS and the PTEN gene Our research Get involved! Additional resources and information Use of animals in research About PTEN Research Our Team Our Trustees Our Scientific Advisory Board Newsletters Connect contact@ptenresearch.org 3rd Floor, Paternoster House 65 St Paul's Churchyard London EC4M 8AB Copyright © 2021 PTEN Research Registered Charity Number: 11773589 Cookie Policy Privacy Policy Terms & Conditions