ABOUT ENZYMATICA RESEARCH DEVELOPMENT PRODUCTS INVESTOR NEWS MENU Product development Clinical studies Publications Scientific advisors Clinical studies Clinical studies on colds The COLDPREV study for ColdZyme ® Mouth Spray The study was conducted at the ear, nose and throat clinic at Skåne University Hospital in the spring of 2013 and shows that ColdZyme Mouth Spray reduces both the amount of virus and the number of cold days compared with placebo. The COLDPREV study was a randomized, double-blind, placebo-controlled clinical trial of ColdZyme Munspray for colds. In the study, 46 subjects, both men and women (20-46 years), were inoculated (infected) with cold viruses through the nose. The study was a first pilot study, with the aim of being the basis for larger studies, and showed a statistically significant difference between ColdZyme and placebo in terms of reducing the amount of virus in the throat (-99%) and reducing the number of cold days (-54%). The study was presented as abstract and items at the Ear, Nose, Throat Congress XXXII Congress of the Nordic Association of Otolaryngology in Copenhagen on 23 May 2014. Link to the abstract. To confirm the results from COLDPREV, a prospective study with the same design on a larger scale will be conducted in 2016, COLDPREV II (link to ClinicalTrials.gov, https://clinicaltrials.gov/ct2/show/NCT02479750) ABOUT ENZYMATICA Business concept and goals Sustainability work Work with us History Contact Us RESEARCH DEVELOPMENT Product development Clinical studies Publications Scientific advisors PRODUCTS ColdZyme® Mouth Spray for colds Calvate ™ - veterinary products Zymetech products INVESTOR Stock information Financial reports Corporate governance Company description First North Presentations Company analyzes Calendar IR contact New issue April 2016 NEWS Press releases Other news Subscribe Image Bank PLUG Ideon Science Park SE-223 70 Lund, Sweden Visit: Scheelevägen 19 Tel: +46 (0) 46-286 31 00 E-mail: info@enzymatica.se TWITTER Fetching Enzymatica tweets ... © 2014-2015 Enzymatica AB

ABOUT ENZYMATICA RESEARCH DEVELOPMENT PRODUCTS INVESTOR NEWS MENU Stock information Financial reports Corporate governance Annual General Meeting Nomination Committee Board Committee Auditor Management Guidelines for compensation Articles of association Company description First North Presentations Company analyzes Calendar IR contact New issue April 2016 Articles of association Articles of association ABOUT ENZYMATICA Business concept and goals Sustainability work Work with us History Contact Us RESEARCH DEVELOPMENT Product development Clinical studies Publications Scientific advisors PRODUCTS ColdZyme® Mouth Spray for colds Calvate ™ - veterinary products Zymetech products INVESTOR Stock information Financial reports Corporate governance Company description First North Presentations Company analyzes Calendar IR contact New issue April 2016 NEWS Press releases Other news Subscribe Image Bank PLUG Ideon Science Park SE-223 70 Lund, Sweden Visit: Scheelevägen 19 Tel: +46 (0) 46-286 31 00 E-mail: info@enzymatica.se TWITTER Fetching Enzymatica tweets ... © 2014-2015 Enzymatica AB