ABOUT COMPANY PRODUCTS DISTRIBUTORS PRESS CENTER SHAREHOLDERS NEWS CONTACTS ENGLISH QUESTION ANSWER VENLAFAXIN ORGANIC Active substance: venlafaxine Pharmacological action: venlafaxine is an antidepressant chemically not belonging to any class of antidepressants, it is a racemate of two active enantiomers. Venlafaxine and its main metabolite O-desmethylvenlafaxine (EFA) are potent inhibitors of serotonin and norepinephrine reuptake and weak dopamine reuptake inhibitors. The mechanism of the antidepressant action of the drug is associated with its ability to potentiate the transmission of nerve impulses in the central nervous system (CNS). Venlafaxine and EFA equally effectively affect the reuptake of the above neurotransmitters, while they have no affinity for cholinergic (muscarinic), histamine (H1), alpha1-adrenergic, opioid and benzodiazepine receptors, do not suppress the activity of monoamine oxidase. It also has no affinity for opiate, benzodiazepine, phencyclidine, or N-methyl-d-aspartate (NMDA) receptors. Absorption from the gastrointestinal tract is good, about 92% for a single dose, the amount does not depend on food intake. The general bioavailability is 40-45%. Indications: Depression. Prevention and Treatment. Method of administration and dosage:Inside. The drug is taken with meals, preferably at the same time, without chewing and drinking a liquid. The recommended starting dose is 75 mg twice daily (37.5 mg twice daily). Depending on the tolerance and effectiveness, the dose can be gradually increased to 150 mg / day, if necessary - up to 225 mg / day. A dose increase of 75 mg / day can be done at intervals of 2 weeks or more. Higher doses require inpatient observation of patients. After achieving the desired therapeutic effect, the daily dose can be gradually reduced to the minimum effective level. Supportive treatment can last 6 months or more. The minimum effective dose used in the treatment of a depressive episode is prescribed. Contraindications:according to instructions. Adverse reactions: according to the instructions. Interaction with other medicinal products: according to the instructions. Special instructions: Discontinuation of the drug should be carried out gradually to minimize the risk associated with cancellation. With a course of treatment for 6 weeks or more, the period of drug withdrawal should be at least 2 weeks and depends on the dose, duration and individual characteristics of the patient. During treatment, you should refrain from taking any alcoholic beverages. Further according to the instructions. Release form: film-coated tablets 37.5 mg No. 30, 75 mg No. 30. Before use, consult a doctor. For more information, see the instructions for use. HELPFUL INFORMATION Results of bioequivalence studies of Venlafaxine Organics and Velaxin The first batch of the antidepressant Venlafaxine Organic has been produced