Hamburger menu iconThree black lines signifying a hidden expanded menu. Get started The most effective acne medications. Period. Treat your acne from the inside out and the outside in. Apostrophe’s proprietary topical formula is matched with proven oral treatments to get you on track to clearer, healthier skin. Topical and oral medications custom curated by your dermatologist. EXPLORE OUR TREATMENTS Topical medication Oral medication Apostrophe Custom Topical Formula $75 FOR A 90 DAY SUPPLY 4.42/5 based on 384 reviews Our proprietary custom topical formula comes packed with prescription-grade ingredients in a moisturizing lotion with 4% niacinamide, aloe and vitamin E. Apostrophe’s topical medication blends seamlessly into your skincare routine– no more weird goopy aluminum tubes. All that tailored to you by your board-certified dermatologist. Get started THE INGREDIENTS The fundamentals of your topical treatment We don’t skimp on efficacy, ever. Apostrophe is rated the most effective acne treatment* by consumers for a reason. We offer the widest range of prescription ingredients and strengths so our doctors can create the formula that’s perfect for your skin. From the most sensitive skin to the most severe acne, our custom topical formula has you covered. Tretinoin 0.018% - 0.1% Metronidazole 1% Clindamycin 1% Azelaic Acid 15% Tazarotene 0.05% Hydroquinone 6% *Based on a survey of 665 Apostrophe patients. Acne treatment you'll want to use. Our nourishing texture makes this prescription treatment blend seamlessly into your skincare routine, unlike goopy generics. Get started Apostrophe Oral Medications $45-$90 FOR A 90 DAY SUPPLY 4.25/5 based on 309 reviews Kickstart your acne treatment with oral medications. Apostrophe offers multiple kinds of antibiotic treatments that target acne-causing inflammation and hormonal acne treatments that can clear stubborn jawline acne in women. Get started Your clear skin secret weapon. Orals are a powerful way to treat stubborn breakouts and hormonal acne. Think of them as your topical treatment’s partner in crime. Antibiotics These medications are typically short course treatments that help get your acne under control quicker. Your doctor will only prescribe these if they feel you’ll get better results. LEARN MORE ABOUT OUR ANTIBIOTICS Hormonal treatment This treatment is for women who experience jawline breakouts that are caused by hormonal imbalances. Your doctor will only prescribe this if they feel you’re a good candidate. LEARN MORE ABOUT OUR HORMONAL TREATMENTS Better, together. Your Apostrophe treatment plan may contain several of these power-packed medications. Your dermatologist will design your medication to work synergistically together so you can get the best possible outcomes. Get started “Acne medications work best in combination since we’re able to fight acne from different angles. Only topical treatments target the root cause of acne, the clogged pore, but oral medications can quickly reduce inflammation to kickstart rapid improvement.” AIMEE PAIK, MD Real Patients, real results. Read reviews of our topical and oral medications below. 4.33/5 based on 820 reviews. All medications Topicals Orals All ratings 5 Star 4 Star 3 Star 2 Star 1 Star 821 REVIEWS INGREDIENTS: 11/21/2021 While this dried my face out for the first two weeks, it has rapidly reduced my breakouts and my skin texture feels so much better. DALLAS INGREDIENTS: 11/14/2021 So far Im really liking this treatment. Skin is staying clear, and any time I have a pimple it usually goes away the next day/overnight! EMEKA NWOKOBIA INGREDIENTS: CLINDAMYCIN, TRETINOIN, NIACINAMIDE 11/13/2021 This is the treatment my skin has always wanted but I've long denied it. So great seeing my skin respond to me showing it some love. Love my clearer, more controlled skin. ANA INGREDIENTS: TRETINOIN, NIACINAMIDE 11/12/2021 I love the way my face feels soft PATRICIA INGREDIENTS: 11/12/2021 Love the combination of treatments in an easily spreadable gel cream. KATHERINE INGREDIENTS: SPIRONOLACTONE 11/11/2021 if your acne is caused by excess testosterone production this is a godsend.. I had cystic acne on both sides around my jawline and it has cleared up ever since I started spiro. You do have to drink a lot of water when on this medication or else you will be constipated. I have noticed my pmdd symptoms have been much better as well but that may be the diuretic effect that helped pre menstrual bloating. EMMA INGREDIENTS: AZELAIC ACID, NIACINAMIDE 11/11/2021 After using this product with light ceve lotion my skin has never been softer and is clearing up faster than I couldve hoped! CAITLYN INGREDIENTS: 11/10/2021 I've started seeing results pretty quickly! I'm hoping it stays this way! The only thing I'm disappointed about is the size of the bottle. Its extremely small. There is no way this will last me 3 months. ASHLEIGH INGREDIENTS: 11/4/2021 I so far am loving this stuff! Like absolutely obsessed. My skin feels brand new. Before I started this formula, I was so inflamed, I couldn't do anything to get my acne under control. Now my acne actually feels under control, my skin isn't inflamed, my skin is so much softer. I can't wait to continue using this stuff and keep seeing the benefits because I know Tretinoin has anti-aging benefits so I am excited to see how it keeps working. Love this stuff! 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