COVID-19 COVID-19 Programs COVITRACE™ (Diagnostic Test for the Detection of SARS-CoV-2 in Nasal Swab and Saliva) COVISTIX™ (Antigen Test for the Detection of SARS-CoV-2 Virus in Nasal Swab) COVITRACK™ Platinum (Antibody Test for the Detection of Antibodies to SARS-CoV-2 in Blood) COVIGUARD™ (Neutralizing Antibody – STI 1499) COVI-AMG™ (Affinity Matured COVI-GUARD Neutralizing Antibody – STI 2020) COVIDROPS™ (Intranasal COVI-AMG Neutralizing Antibody – STI 2099) COVISHIELD™ (Neutralizing Antibody Cocktail) COVIDTRAP™ (ACE2 Receptor Decoy – STI 4398) ABIVERTINIB (Cytokine Storm – STI 5656) SALICYN-30 (Anti-viral – STI 2030) COVI-MSC (Acute Respiratory Distress Syndrome – STI 8282) COVITRACE COVISTIX COVITRACK COVIGUARD COVI-AMG COVIDROPS COVISHIELD COVIDTRAP ABIVERTINIB SALICYN-30 COVI-MSC © 2021 Sorrento Therapeutics, Inc. All Rights Reserved. Terms of Use | Forward Looking Statements | Privacy Policy | Cookie Policy | Notices

LYMPHATIC DELIVERY SYSTEM The Sofusa® Lymphatic Delivery System (S-LDS) is a new method of treatment designed to deliver injectable medicines directly into lymphatic and systemic capillaries just beneath the epidermis via a proprietary microneedle and microfluidics system. Sofusa Lymphatic Delivery System Overview. Visit www.sofusa.com » Enhanced Absorption Unlike traditional injections, the Sofusa (“soft transdermal infusion) system enables controlled absorption into tiny lymphatic and systemic capillaries just beneath the epidermis. Nanotopography (highly magnified) Proprietary thin film nanotopography applied to microneedles results in a dramatic increase in absorption of large molecules vs undraped microneedles Intra-Lymphatic Targeting In pre-clinical models compared to traditional injection, Sofusa has demonstrated improved clinical response with increased in lymphatic concentrations and reduced systemic exposure1. (1) Data on file – Multiple pre-clinical studies involving etanercept, trastuzumab, CTLA-4, PD-1, and PD-L1 © 2021 Sorrento Therapeutics, Inc. All Rights Reserved. Terms of Use | Forward Looking Statements | Privacy Policy | Cookie Policy | Notices