Minakem is a brand of Minafin Home Contacts Menu Minakem News & Events News Scientific Publication Electroreductive Olefin–Ketone Coupling Electroreductive Olefin–Ketone Coupling October 10, 2021 in Scientific Publication YOU ALSO MAY BE INTERESTED IN SCIENTIFIC PUBLICATION Electroreductive Olefin–Ketone Coupling October 10, 2021 Abstract: A user-friendly approach is presented to sidestep the venerable Grignard addition to unactivated ketones to access tertiary alcohols by reversing the polarity of… SCIENTIFIC PUBLICATION Electrochemically driven desaturation of carbonyl compounds October 2, 2021 Abstract: Electrochemical techniques have long been heralded for their innate sustainability as efficient methods to achieve redox reactions. Carbonyl desaturation, as a fundamental organic… SCIENTIFIC PUBLICATION Carbonyl Desaturation: Where Does Catalysis Stand? September 23, 2021 Abstract: There is a strong parallel between simple alcohol oxidation and carbonyl desaturation from both strategic and tactical vantage points. As they both seek… Abstract: A user-friendly approach is presented to sidestep the venerable Grignard addition to unactivated ketones to access tertiary alcohols by reversing the polarity of the disconnection. In this work a ketone instead acts as a nucleophile when adding to simple unactivated olefins to accomplish the same overall transformation. The scope of this coupling is broad as enabled using an electrochemical approach, and the reaction is scalable, chemoselective, and requires no precaution to exclude air or water. Multiple applications demonstrate the simplifying nature of the reaction on multistep synthesis, and mechanistic studies point to an intuitive mechanism reminiscent of other chemical reductants such as SmI2 (which cannot accomplish the same reaction). Access the full article now Source J. Am. Chem. Soc. 2020, 142, 50, 20979–20986 Publication Date: December 1, 2020 Graphical Abstract Authors: Pengfei Hu, Byron K. Peters, Christian A. Malapit, Julien C. Vantourout, Pan Wang, Jinjun Li, Lucas Mele, Pierre-Georges Echeverria, Shelley D. Minteer*, and Phil S. Baran* You may also ask to get in contact with our technical team through our contact form Minakem Recherche, 145 Chemin des Lilas, 59310 Beuvry la Forêt, France PREVIOUS POST Stay in touch? Leave us your e-mail address to receive our latest news SUBSCRIBE About us Mission – Values History Facilities Quality Commitment Environment, Health & Safety Products & Services Pharma Services Additional Services Product Catalog News & Events News Events Ressources CDMO.pdf Analytical services.pdf Product List Building Blocks & GMP excipients.pdf Product List Generic APIs & HPAPIs.pdf Cover Story – Minakem Top 10 CMO Contacts Find us © 2021 Minakem Minakem is a brand of Minafin Privacy Policy Website by Adrénaline