HOME ABOUT PIPELINE BUSINESS DEVELOPMENT CAREERS CONTACT 11/15/2021: Sentynl Therapeutics Recognizes Menkes Disease Awareness Month, Committed to the Development of Assays for Early Diagnosis of Patients with Menkes Disease Sentynl Therapeutics is a US-based biopharmaceutical company that acquires, develops and commercializes prescription products. We provide healthcare professionals with treatment solutions that enable them to meet the needs of individual patients. Sentynl is committed to the highest ethical standards and compliance with all applicable laws, regulations, and industry guidelines. © 2015-2021 by Sentynl Therapeutics, Inc. All Rights Reserved. Terms of Use Privacy Report an Adverse Event Corporate Compliance

HOME ABOUT PIPELINE BUSINESS DEVELOPMENT CAREERS CONTACT About Menkes Disease Menkes disease is a rare X-linked pediatric disease caused by gene mutations of copper transporter ATP7A. Biochemically, Menkes patients may have low levels of copper in their blood and brain, as well as abnormal levels of catecholamine. The condition is characterized by distinctive clinical features, including sparse and depigmented hair (“kinky hair”), failure to thrive, connective tissue disorders and severe neurological symptoms such as seizures. Definitive diagnosis is typically made by sequencing of the ATP7A gene. If untreated, mortality for Menkes disease is high, with many patients dying before the age of three. Currently, there is no FDA-approved treatment for Menkes disease and related disorders in copper metabolism. For more information about Menkes disease, please visit the following sites: National Institutes of Health (NIH) https://rarediseases.info.nih.gov/diseases/1521/menkes-disease National Organization for Rare Disorders (NORD) https://rarediseases.org/rare-diseases/menkes-disease/ © 2015-2021 by Sentynl Therapeutics, Inc. All Rights Reserved. Terms of Use Privacy Report an Adverse Event Corporate Compliance

HOME ABOUT PIPELINE BUSINESS DEVELOPMENT CAREERS CONTACT Safety Contact If you are experiencing a medical emergency, call 911. To report a side effect, product quality complaint, or if you have a Medical Affairs question, call 877-767-2656. To report a side effect to FDA, call 800-FDA-1088 (800-332-1088) or go to www.fda.gov/Safety/MedWatch. Name * First Name Last Name Email Address * Phone (###) ### #### Subject * Message * © 2015-2021 by Sentynl Therapeutics, Inc. All Rights Reserved. Terms of Use Privacy Report an Adverse Event Corporate Compliance