topmenu Careers Contact Main navigation QUALITY ASSISTANCE PRODUCT EXPERTISE ANALYTICAL SERVICES RESOURCES NEWS & EVENTS SEARCH ENTER YOUR KEYWORDS Development of orthogonal chromatographic methods for the purity analysis of therapeutic oligonucleotides RESOURCES … Oligonucleotides have been in clinical development for approximately 30 years. Anti-sense oligonucleotides and aptamers were initially developed, … numerous clinical trials were performed and thousands of oligonucleotides underwent studies for a possible market … Absolute Quantification of Oligonucleotides by ICP-MS/MS RESOURCES … an analytical method for the absolute quantification of oligonucleotides is a prerequisite. In this application … by triple quadrupole ICP-MS for the quantification of oligonucleotides in drug substances and drug products. The … the method was studied in terms of precision and accuracy. Oligonucleotides are a promising class of therapeutics, that … Oligonucleotides: Absolute quantification and P=O/P=S in a single ICP-MS/MS run RESOURCES … digestion of the sample: accurate quantification of oligonucleotides can be performed using the fixed … Sodium may also be determined with the same method. … Oligonucleotides: Absolute quantification and P=O/P=S in a … Oligonucleotides: A serious analytical challenge in terms of analytical characterisation ARTICLE … Oligonucleotides: A serious challenge in terms of analytical … by Arnaud Delobel , R&D Director at Quality Assistance S.A. Oligonucleotides are a promising class of therapeutics that … we solely focus on the analytical characterisation of oligonucleotides and on the development and validation of … OLIGONUCLEOTIDES: absolute quantification and P=O/P=S ratio in a single ICP-MS/MS run RESOURCES … is a critical quality attribute of phosphorothioate oligonucleotides. Quality Assistance developed an … by ICP-MS/MS to allow: Accurate quantification of oligonucleotides, without reference substance Easy … determine the P=O/P=S ratio in oligonucleotide samples. … OLIGONUCLEOTIDES: absolute quantification and P=O/P=S … Oligonucleotides : absolute quantification and P=O/P=S ratio in a single ICP-MS/MS run RESOURCES … is a critical quality attribute of phosphorothioate oligonucleotides. The determination of this ratio is … samples. The method could be used in routine testing of oligonucleotides in a GxP environment, as an orthogonal … be a solution for a fast and accurate generic method for oligonucleotides quantification without the reference oligo … Innovative ICP-MS/MS approach for the determination of phosphodiester to phosphorothioate ratio in phosphorothioate oligonucleotides RESOURCES … is a critical quality attribute of phosphorothioate oligonucleotides. The determination of this ratio is … samples. The method could be used in routine testing of oligonucleotides in a GxP environment, as an orthogonal … is a critical quality attribute of phosphorothioate oligonucleotides. The determination of this ratio is … Development of orthogonal chromatographic methods for the purity analysis of therapeutic oligonucleotides RESOURCES … Oligonucleotides have been in clinical development for the … clear clinical benefit in rigorously controlled trials. Oligonucleotides are synthetised by a chemical process. … oligonucleotide of interest of a given length n but also oligonucleotides of unwanted length, such as n-1 … Oligonucleotide Therapeutics Society Annual Meeting EVENTS … many technical challenges associated with the analysis of oligonucleotides . With a highly experienced staff and … has developed specific methods for the analysis of oligonucleotides: Characterisation studies by ICP-MS … International Oligonucleotides and peptides conference 2019 EVENTS … Assistance attended the International Oligonucleotides and peptides conference (IOPC)! With more than 35 years’ … the registration process. Peptide expertise Therapeutic peptides are at the crossroads of small molecules and … registration. … … International Oligonucleotides and peptides conference 2019 … event … Pagination Current page 1 Page 2 Page 3 NEXT PAGE ›› New Biological Entities NBEs mAbs (Monoclonal Antibodies) ADCs (Antibody-Drug Conjugates) Proteins New Chemical Entities NCEs Peptides Oligonucleotides Nanomedicine Products Vaccines Advanced Therapy Medicinal Products GTMPs (Gene Therapy Medicinal Products) CBMPs (Cell-Based Medicinal Products) mRNA Quality Assistance About Us Corporate governance Key figures A leading analytical CRO Quality & Regulatory R&D and Innovation Life @Quality Assistance Analytical Services Analytical Development Stability studies Batch testing Bioanalytical services Elemental Impurities Characterisation of proteins by MS Resources Product brochures Scientific Library Study & Technical sheets Scientific posters Publications & Application notes Webinars Conferences Media Library News & Events News Events © Quality Assistance s.a., 2017. 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