Home Resources Technologies Explore Microsatellite Instability Microsatellite Instability is the accumulation of insertion or deletion errors at microsatellite repeat sequences in cancerous cells as a result of a functional deficiency within one or more major DNA mismatch repair proteins (dMMR). Mononucleotide (homopolymer) repeat microsatellite sequences found throughout the genome are particularly sensitive to transcription errors. Thus, high frequency microsatellite instability (MSI-H) is considered a marker for the presence of mutations in, or methylation silencing of, certain major DNA MMR genes. Historically MSI has been used to screen for Lynch Syndrome, a dominant hereditary cancer propensity. Recently, MSI status has been rediscovered as a biomarker for immunotherapeutic response, making MSI status an increasingly relevant tool in genetic- and immuno-oncology. Request more information What is MSI? Importance of MSI Status Learn the ways MSI status is used as a valuable biomarker for cancer risk and to inform treatment decisions. Methods of Detection Compare the different methods used to measure MSI and MMR status. Co-Testing Benefits Learn more about the added benefits of testing using both MSI by PCR and dMMR by IHC. Understanding Lynch Syndrome Learn more about the importance of determining Lynch status. PCR Workflow Learn about the process and equipment required to determine MSI status using PCR Don't miss out! Stay notified of Promega events, products and news. Sign Up Need Assistance? Contact Promega Customer and Technical Support Local Contact +31 (0)71 532 42 44 Products & Resources Products Applications Custom Capabilities Resources About Promega Company Info ISO Certification Corporate Responsibility Press Releases Careers © 2021 Promega Corporation, an affiliate of Promega Benelux BV. All rights reserved. Legal and Trademarks Privacy Policy Terms and Conditions Trademarks Promotional Terms and Conditions Terms and Conditions of Sale and Services Manage Cookie Consent English – Belgium Promega's Cookie Policy Close We use cookies and similar technologies to make our website work, run analytics, improve our website, and show you personalized content and advertising. Some of these cookies are essential for our website to work. For others, we won’t set them unless you accept them. To find out more about cookies and how to manage cookies, read our Cookie Policy. If you are located in the EEA , the United Kingdom, or Switzerland, you can change your settings at any time by clicking Manage Cookie Consent in the footer of our website. Manage My Cookies Reject All Cookies Yes, I Accept