Now offering personalized allergy treatment: Start free visit What we treat ALLERGY RELIEF Levocetirizine Generic Xyzal Levocetirizine dihydrochloride Fast-acting (within an hour) oral medication. Works for 24 hours. FDA-approved for relief of symptoms associated with seasonal and perennial (year-round) allergic rhinitis. Start online visit Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a healthcare provider. How to Use Take 1 tablet by mouth every night at bedtime. May be taken with or without food. Common Side Effects Sleepiness, fatigue, nasal irritation, dry mouth, and sore throat. Levocetirizine was designed to be less sedative than Zyrtec, but it may still cause sleepiness in some users, so we recommend taking it at night. Transparent Manufacturing Levocetirizine is manufactured in the USA. Start online visit Important safety information Do NOT use levocetirizine while taking Allegra (fexofenadine), Claritin (loratadine), Zyrtec (cetirizine), or other oral antihistamines. If taking one of those medications, talk to your Ro-affiliated doctor about discontinuing use prior to taking levocetirizine. Allergy medication works best when taken every day. Be sure to continue using your medication as directed, even after your symptoms have improved. Members can message their doctor any time with treatment questions or requests. U.S.-licensed physician or nurse practitioner Licensed pharmacy Free 2-day shipping Unlimited follow-ups What is levocetirizine? How does levocetirizine work? How should levocetirizine be taken? Is buying levocetirizine online safe? Side effects Important safety information What is levocetirizine? Levocetirizine is a type of medication known as a third-generation antihistamine. Antihistamine medications block the action of histamine, an inflammatory chemical the body releases during an allergic reaction. The release of histamine leads to a number of symptoms including watery eyes, runny nose, sneezing, and itchy skin. Levocetirizine helps stop these symptoms from happening. Levocetirizine is derived from another medication called cetirizine, which is more commonly known by its brand name, Zyrtec. However, it is believed that levocetirizine may cause less drowsiness than cetirizine. How does levocetirizine differ from Xyzal? Levocetirizine is the generic form of the brand name medication, Xyzal. The two medications are considered equivalent. The U.S. Food and Drug Administration requires that generic drugs demonstrate bioequivalence to the brand name drug, which means they act the same way in the body and are expected to produce the same effects as the original brand name drug. How does levocetirizine work? Levocetirizine works by blocking the H1 receptors on cells, which are receptors that are normally activated by the chemical histamine. When the body is exposed to an allergen, immune cells (called mast cells and basophils) release histamine. Since levocetirizine blocks histamine from activating the H1 receptors, the symptoms that are typically caused by histamine are lessened. How should levocetirizine be taken? Levocetirizine is an oral medication that should be taken by mouth once daily in the evening. If possible, it should be taken at the same time each day. What if you miss a dose? If you accidentally miss a dose and remember later at night, take it when you remember. However, if you remember the next day, keep in mind that this medication may cause drowsiness. If it is more than a few hours before when your next dose is supposed to be, you may take the missed dose but should be prepared for the possibility that you may not be able to drive or operate heavy machinery. If you remember within a few hours of when your next dose is supposed to be, skip the missed dose and resume your normal schedule. Do not take a double dose. What if you take more than you are prescribed? Taking extra doses of levocetirizine in a 24-hour period may result in drowsiness, agitation, or restlessness. There is no specific treatment for a levocetirizine overdose. If you are experiencing symptoms, contact poison control and a healthcare provider immediately. While overdose is possible, death is unlikely to occur from taking an extra daily dose by accident. In tests done on mice, the maximum non-lethal dose of levocetirizine was approximately 200 times the daily dose in humans. In tests done on rats, the maximum non-lethal dose of levocetirizine was approximately 390 times the daily dose in humans. Is buying levocetirizine online safe? With Roman, you can always be sure you are getting genuine medication. Roman dispenses drugs that are FDA approved and manufactured by pharmaceutical companies that adhere to the FDA’s manufacturing standards for finished drug products. In fact, you will likely find many of the same manufacturers we use in your local pharmacy. Side effects Levocetirizine may cause nasal irritation, dry mouth, and sore throat. Levocetirizine may be mildly sedating. Users should exercise caution when taking levocetirizine and should be aware that mental alertness may be decreased. This can impact the ability to drive or operate machinery. Additional possible side effects include seizures, angioedema, anaphylactoid reactions, hemolytic anemia, suicidal ideation, acute generalized exanthematous pustulosis (AGEP), glomerulonephritis, visual impairment, constipation, elevated hepatic enzymes, dyspnea, dyskinesia, thrombocytopenia, sinus tachycardia, palpitations, hypotension, hepatitis, cholestasis, hallucinations, dystonic reaction, depression, myoclonia, dysuria, urinary retention, blurred vision, diarrhea, drowsiness, nasal congestion, fatigue, fever, cough, xerostomia, infection, pharyngitis, epistaxis, insomnia, pruritus, urticaria, rash, weight gain, agitation, syncope, dizziness, arthralgia, tremor, asthenia, myalgia, vertigo, vomiting, dysgeusia, nausea, and paresthesias. Important safety information The information here is taken from the Prescriber’s Digital Reference (PDR), which can be found here. Contraindications & precautions Levocetirizine should not be used by anybody who has an allergy or sensitivity to levocetirizine, cetirizine, or hydroxyzine. Levocetirizine should not be used by anybody who is pregnant or nursing. Levocetirizine is contraindicated in patients on dialysis or patients with kidney failure or kidney impairment. Levocetirizine should be used with caution in geriatric patients and patients with bladder obstruction, prostatic hypertrophy, or urinary retention. Drug interactions Levocetirizine should not be used with alcohol or with other medications that depress the central nervous system. Levocetirizine interacts with the medications theophylline and ritonavir. The full list of medication interactions is listed in the PDR. Prescription relief, without the waiting room All of our FDA-approved allergy treatment options were hand selected by our in-house, board-certified ENT. Complete a free online visit and, if appropriate, a doctor or nurse practitioner will prescribe a personalized treatment plan that’s best for you. Finding the right allergy treatment shouldn’t be a guessing game. Start online visit Free 2-day shipping Rx treatments Free + unlimited follow ups Pause or cancel anytime Login Have a question? Email us anytime care@ro.co More questions? Visit our FAQ page Instagram Facebook Youtube Twitter LinkedIn What We Treat About Roman Support Legal Powered by © 2021 Roman Roman-affiliated physician practices are independently owned and operated by licensed physicians who provide services utilizing the Roman telehealth platform. To learn more about Roman, please visit www.ro.co. Major League Baseball trademarks and copyrights are used with permission of Major League Baseball. Visit MLB.com.