About Us Contact Us Resources News & Events Technical Support Careers Applications Products Services Life Cycle Formulation Science Home • Life Cycle • Development • Formulation Science • LIGHTHOUSE supports the formulation science of pharmaceuticals by providing broad product and service offerings that can be utilized throughout the entire product lifecycle. Large molecule biopharmaceuticals are delicate and can be prone to oxidation while dry product needs to be protected from hydrolysis. Headspace analyzers from LIGHTHOUSE are ideal analytical platforms to investigate formulation stability against oxygen or moisture. The nondestructive nature of the analysis means that valuable product is not destroyed and can be reused for other formulation science activities. Stability Testing Oxygen Moisture Stability Testing Understanding a pharmaceutical’s reactivity to oxygen and/or moisture is a critical part of optimizing a product’s shelf life and ensuring its efficacy. LIGHTHOUSE headspace platforms are specifically designed to check for defects, leaks, or other packaging problems that might compromise a product’s sterility or stability. The rapid nondestructive nature of measurements enable studies involving statistical sample sets, ensuring deeper insight into product stability and enabling the monitoring of a sample over the full shelf life. Lighthouse Oxygen Monitoring Oxygen The headspace gas composition in pharmaceutical product containers is critical if the formulation is oxygen sensitive. Monitoring and controlling headspace oxygen levels throughout the product life cycle becomes necessary to determine accurate stability specifications, monitor nitrogen purging processes during filling, and to assure product stability throughout shelf life. Laser-based non-destructive headspace oxygen analyzer platforms from LIGHTHOUSE effectively and reliably replace destructive electrochemical and GC methods for determining the oxidation of oxygen sensitive formulations. Headspace Oxygen Monitoring of Pre-filled Syringes FMS-Oxygen Headspace Analyzer Webinar: Oxygen Permeation in Pre-filled Syringes Webinar: Protecting Oxygen Sensitive Formulations CCIT in Lieu of Sterility Testing Poster: Oxygen Monitoring in Pre-Filled Syringes Poster: Assessing Oxidative Degradation Case Study: Headspace Oxygen Consumption Study Poster: Oxygen Permeation Rates through Syringe Components Moisture LIGHTHOUSE understands that residual product moisture content is a critical parameter when considering the stability and shelf life of lyophilized pharmaceutical product, sterile powders, or solid dosage product. LIGHTHOUSE replaces slow traditional methods with a rapid, non-destructive method that streamlines moisture analysis efforts and helps improve the quality of a finished product. The rapid analytical measurement enables studies using statistical sample sets and the nondestructive nature of the analysis saves valuable product in development activities. White Paper: Moisture Determination of Freeze Dried Product Poster: Freeze Dried Cakes –Where is the water? Webinar: New Draft USP 922 Chapter for Water Activity Measurements FMS-Pressure/Moisture Headspace Analyzer Case Study: Stability Study Moisture Permeation FMS-Water Activity Analyzer Webinar: Non-Destructive Moisture Analysis of Freeze Dried Product Quick Links APPLICATIONS Container Closure Integrity Testing Oxygen Monitoring Water Activity Determination Moisture Determination PRODUCTS Automation Laboratory Instruments SERVICES Lab Testing On-site Testing Equipment Lease LIFE CYCLE Development Manufacturing Quality Control Contact Us Wherever you need support optimizing product and process quality throughout the product lifecycle, LIGHTHOUSE experts are available for you. Request Info Corporate Headquarters 2050 Avon Court Charlottesville, VA 22902 Telephone: +1 (434) 293-3081 E-mail: info@lighthouseinstruments.com European Support Center Science Park 408 1098XH Amsterdam The Netherlands Telephone: +31 20 7051 050 E-mail: euinfo@lighthouseinstruments.com Site Map | Cookie Policy | Privacy Policy | Terms of Use Subscribe to our newsletter Sign up to receive information on headspace analysis applications, industry updates, webinars and other events. Select your application area of interest below: LIGHTHOUSE © 2021 | Website created by Advanta Advertising, LLC