About Us Clinical Pipeline Science Products Careers Contact CURRENT THERAPEUTIC FOCUS Immune and Fibrotic Diseases Structure-Based Drug Design Kadmon has established a structure-based drug design (SBDD) platform to develop uniquely targeted therapies. Our SBDD platform supports target characterization and facilitates drug development by combining data from x-ray crystallography with molecular modeling and other computational tools. These methods allow for a nuanced understanding of molecular structures and interactions with targets to support development of drug candidates. Combining SBDD efforts with innovative structural biology and medicinal chemistry provides for a rapid and cost-effective lead optimization process. KD045 KD045, which was discovered using the SBDD platform, is a potent, selective, oral inhibitor of ROCK for the treatment of fibrotic diseases. In mouse models of lung, kidney and liver fibrosis, KD045 demonstrated robust activity, highlighting the therapeutic potential of ROCK inhibition and supporting clinical development of this agent. KD045 is currently in preclinical development. 450 East 29th Street New York, New York 10016 55 Cambridge Parkway, Suite 300E Cambridge, Massachusetts 02142 119 Commonwealth Drive Warrendale, Pennsylvania 15086 Site MapPrivacy PolicyTerms of UseCalifornia Compliance © 2021 Kadmon, a Sanofi Company. All Rights Reserved.

About Us Clinical Pipeline Science Products Careers Contact At Kadmon, we are a group of dedicated individuals who share a collective goal to develop transformative therapies for patients in need. We seek dynamic, motivated team players to join us. View available positions here: Open Positions 450 East 29th Street New York, New York 10016 55 Cambridge Parkway, Suite 300E Cambridge, Massachusetts 02142 119 Commonwealth Drive Warrendale, Pennsylvania 15086 Site MapPrivacy PolicyTerms of UseCalifornia Compliance © 2021 Kadmon, a Sanofi Company. All Rights Reserved.

About Us Clinical Pipeline Science Products Careers Contact CURRENT THERAPEUTIC FOCUS Immune Disorders, Fibrotic Diseases and Cancer 450 East 29th Street New York, New York 10016 55 Cambridge Parkway, Suite 300E Cambridge, Massachusetts 02142 119 Commonwealth Drive Warrendale, Pennsylvania 15086 Site MapPrivacy PolicyTerms of UseCalifornia Compliance © 2021 Kadmon, a Sanofi Company. All Rights Reserved.

About Us Clinical Pipeline Science Products Careers Home About Us Our Company Kadmon Commitment Contact Clinical Pipeline Pipeline About cGVHD About Belumosudil About KD033 Clinical Trials Science Preclinical Pipeline Biologics Monoclonal Antibody Discovery Platform IL-15 Platform Small Molecules Structure-Based Drug Design Publications and Posters Careers Site Map Privacy Policy Terms of Use California Compliance 450 East 29th Street New York, New York 10016 55 Cambridge Parkway, Suite 300E Cambridge, Massachusetts 02142 119 Commonwealth Drive Warrendale, Pennsylvania 15086 Site MapPrivacy PolicyTerms of UseCalifornia Compliance © 2021 Kadmon, a Sanofi Company. All Rights Reserved.