mail@hyphadiscovery.com Search What We Do Products Our Metabolite Expertise Why Choose Us About Us Resources News & Blog Events Contact Us Experts in Metabolite Synthesis, Purification and Natural Products Supporting pharmaceutical and agrochemical companies globally Find Out More Your trusted partner in pharmaceutical and agrochemical R&D What we do Hypha Discovery is a specialist CRO supporting pharmaceutical and agrochemical companies worldwide through the production of metabolites and late-stage derivatives of drugs and agrochemicals in discovery and development. We are experts in the scalable synthesis, purification and identification of drug metabolites and oxidised derivatives of lead compounds, and also possess a wealth of experience in the production, purification and structure elucidation of natural products. Find Out More Metabolite Synthesis Custom Natural Product Synthesis Custom Natural Product Synthesis Purification Late-stage Functionalisation Late-stage Functionalisation NMR Spectroscopy and Structure Elucidation Solutions for metabolite synthesis Hypha Discovery offer a comprehensive suite of techniques for provision of even the most difficult-to-synthesise metabolite, comprising chemical synthesis, recombinant enzymes such as PolyCYPs, microbial biotransformation, mammalian liver fractions as well as the purification of metabolites from biological matrices. We are also experts in the structure elucidation of metabolites by NMR spectroscopy Chemical Synthesis Late-stage chemical glucuronidation Mammalian biotransformation Panels of liver S9s / microsomes Microbial biotransformation Proven panels of bacteria and fungi Purification & structure elucidation COAs, acquisition / interpretation of NMR data Recombinant enzymes PolyCYPs, hrCYPs, AOX, FMOs PolyCYPs kits PolyCYPs+ screening kits comprise 18 PolyCYP isoforms together with the addition of other phase 1 enzymes. Human aldehyde oxidase (AOX1) and the main human hepatic flavin-containing monooxygenase (FMO3) are included in the kit, with the other human FMO isoforms, available separately at Hypha. Inclusion of multiple PolyCYPs isoforms broadens coverage of reactions, and which have been proven to produce human and other mammalian CYP-derived metabolites including multi-step metabolites and metabolites of low turnover drugs. Simple, Effective, Scalable Produce CYP, AOX & FMO metabolites Generate multiple hydroxylated and other oxidised derivatives of lead compounds in parallel Find Out More About Us Delivering a first class service to our clients worldwide Expertise Hypha Discovery is your trusted global partner. We are go-to experts for metabolite solutions and have worked with many of the top pharma and agrochemical companies worldwide to deliver projects. Flexibility We will work with you to design a custom solution that meets your needs and which can be adapted in response to project milestones. Service We pride ourselves on our client focused approach. Our scientists will work with you to personally deliver your project. Find Out More We contacted Hypha Discovery to generate specific phase I and phase II metabolite standards in sufficient quantities and purity to allow structural confirmation and quantitation. Hypha exceeded expectations, providing 60mg of a phase I metabolite and over 100mg of a phase II metabolite at high purity. Hypha’s team was a pleasure to work with and communicative and responsive throughout the process. We will undoubtedly be working with Hypha Discovery in the future. Jason Boer, Associate Director Incyte Corporation, Wilmington, USA Hypha Discovery News View All Q4 2021 Newsletter – Metabolite identification by PolyCYPs and Kit Offer In our Q4 2021 technical newsletter we describe how Hypha used PolyCYPs to help the Open Source Antibiotics team identify a drug metabolite. READ MORE Q3 2021 Newsletter – Glucuronide and glucoside synthesis We look at the synthesis of glucuronides and glucose conjugates in our Q3 2021 technical newsletter. READ MORE Q2 2021 Newsletter – Deuterated metabolites We discuss the synthesis of deuterated metabolites and purification of metabolites from complex mixtures in our Q2 2021 newsletter. READ MORE Stay up to date with the latest news from Hypha Discovery Sign up for our Newsletter to receive interesting updates and scientific case studies about Hypha’s metabolite generation capabilities and lead optimization solutions Subscribe now Events Meet us at one of the conferences we’ll be attending this year. Find out more Publications Read about our publications in the fields of metabolite synthesis, biotransformation and natural products chemistry Find out more Brochures Access brochures on drug metabolite synthesis, Hypha’s one-stop metabolite shop and the PolyCYPs platform Find out more Ready to begin? Our scientists are available to talk through your requirements Contact Us Submit Hypha Discovery is a UK-based CRO supporting pharmaceutical and agrochemical companies worldwide through the production of metabolites and new derivatives of drugs and agrochemicals in discovery and development. What We Do Metabolite Synthesis Purification Structure Elucidation & NMR Certificates of Analysis Late Stage Functionalisation Custom Natural Product Synthesis Contract Fermentation Our Products PolyCYPs+ Kits for Metabolites PolyCYPs Kits for Late-Stage Oxidation PolyCYPs+ Kit Instructions Human AOX Human FMOs Our Science One-Stop Metabolite Shop Late Stage Chemical Synthesis Mammalian Biotransformations Microbial Biotransformation Purification & Structure Elucidation Recombinant Enzymes Resources Brochures Case Studies Publications Cookie Policy | Privacy Policy | Website Terms and Conditions | Sitemap © Hypha Discovery 2021. All Rights Reserved. Website by Fifteen.co.uk