Search Clinical Studies Clinical studies are critical to help deliver innovative medicines to people with cancer. These studies ensure that an investigational medicine is effective and safe. We are grateful to the patients, healthy volunteers, families, hospitals and clinics that participate in our clinical studies and help make progress possible. For more information, follow the links below to the study listings on clinicaltrials.gov. Medical professionals may also email us at clinicaltrials@deciphera.com for specific questions related to our clinical studies. Our clinical studies Ripretinib Vimseltinib Rebastinib DCC-3116 twitter linkedin CONTACT US Main navigation Discovery Platform Pipeline Ripretinib Vimseltinib DCC-3116 Preclinical Pipeline Expanded Access Our Medicine QINLOCK® (ripretinib) Who We Are Management Board of Directors Join Us Open Positions Footer Utility Contact Us Terms of Use Privacy Policy Recruiting Privacy Policy Web Accessibility Statement © 2021 Deciphera Pharmaceuticals, Inc. QINLOCK and the QINLOCK logo are registered trademarks of Deciphera Pharmaceuticals, LLC. Deciphera and the Deciphera logo are trademarks of Deciphera Pharmaceuticals, LLC.

Search DCC-3116 Image ULK kinase inhibition for cancers caused by RAS/RAF mutations DCC-3116 in an investigational, orally administered, potent, and highly selective switch-control inhibitor of the ULK kinase that was discovered using our proprietary drug discovery platform. DCC-3116 is designed to inhibit autophagy, a key tumor survival mechanism in cancer cells, by inhibiting the ULK 1/2 kinases, which have been shown to be the initiating factors that activate autophagy. DCC-3116 in combination with RAS/MAP kinase signaling pathway inhibition has the potential to change the treatment of RAS/RAF cancers. Cancers caused by RAS/RAF mutations are the most common activating mutations of all cancers and represent a significant unmet medical need. The RAS mutation activates signaling through the MAPK (RAF-MEK-ERK) pathway and the autophagy pathway. MAPK inhibitors have not been successful thus far as single agents for the treatment of cancers caused by RAS mutations. DCC-3116 Phase 1 Study Related Presentations and Publications twitter linkedin CONTACT US Main navigation Discovery Platform Pipeline Ripretinib Vimseltinib DCC-3116 Preclinical Pipeline Expanded Access Our Medicine QINLOCK® (ripretinib) Who We Are Management Board of Directors Join Us Open Positions Footer Utility Contact Us Terms of Use Privacy Policy Recruiting Privacy Policy Web Accessibility Statement © 2021 Deciphera Pharmaceuticals, Inc. QINLOCK and the QINLOCK logo are registered trademarks of Deciphera Pharmaceuticals, LLC. Deciphera and the Deciphera logo are trademarks of Deciphera Pharmaceuticals, LLC.