Technical Papers HOME > TECHNICAL PAPERS Use of Different Mannitol Grades to Improve the Flow and Tableting Properties of Powder Mixtures Dry Granulated by Roller Compaction The evaluation of the tableting properties of granulates obtained by roller compaction (RC) of binary mixtures prepared with different contents of paracetamol fine powder and using different commercial types of mannitol Continue Aqueous Pharmaceutical Coating at Low Temperature Processing – Performance and Scale Up A new pharmaceutical water dispersible coating product has been formulated, which is useful for low temperature processes. Trials have been held at laboratory and production scale in order to assess equivalent finished coated product. During the coating process, the tablet bed temperature was maintained at temperatures lower than 30oC… Continue BEST ABSTRACT AWARD (AAPS 2020): In-line Measurement of Moisture Using an NIR Filter Photometer in Rotor Processor for Dry Powder-layering Part III The main purpose of this investigation was to demonstrate the use of an NIR filter photometer as an in-line process analytical tool to monitor and characterize absorbances for various events (binder addition, powder addition, equilibrium state, etc.) throughout the dry powder-layering process. Continue In-Line Measurement of Moisture Using an NIR Filter Photometer in Rotor Processor Part II The main purpose of the present study was to continue the investigation using placebo blends and commonly used active pharmaceutical ingredients to further ascertain the suitability of the NIR filter photometer for the in-line measurement of moisture during rotor granulation. Continue Detection of Moisture Using a NIR Filter Photometer on Dynamically Moving Particles in a Rotor Processor Following the FDA’s PAT (Process-Analytical-Technology) initiative in the early 2000s, numerous studies have been conducted utilizing full spectrum near infrared (NIR) sensing technology to monitor moisture in granulation and drying processes…. Continue Innovative Reformulation of a Complex, High-Drug-Load, Modified Release Dosage Form With Reduced Dosing Frequency In this case study, Recro Gainesville resolved these concerns by applying a different technology to create a high-drug-load, twice-daily dosage form much more efficiently than a spray coater could. Continue Evaluation of Different Mannitol Grades in Dry Granulation Process by Roller Compaction Evaluate different commercial grades of mannitol to be used in dry granulation by roller compaction (RC), for comparing the compactability of dry granules obtained. Continue Adjusting the Release Rate of Mesalazine from Matrix Formulations by Addition of various Excipients The issue with Mesalazine is that’s its mostly supplied as very fine powder with extremely poor flowability, and wet granulation is most often used to meet the challenge. However, Mesalazine is prone to degradation by several pathways (e.g. oxidation to oxidation and forms quinoneimine), especially if brought into contact with water. Continue PAT Monitoring of Coating Pan by NIR/PLS Method Calibration Approach To follow the coating pan process by means of NIR technology and to determine the weight gain and the coating thickness of the coated tablets in real time. Continue A Comparison of Spherical Core Materials Used for Controlled Release Drug Layering Processes Three different spherical core materials for use in API layering processes; sugar/starch spheres, microcrystalline cellulose (MCC) spheres and novel maltodextrin/starch (M/S) spheres were coated with 40% Acetaminophen in a dry powder layering process. The three core materials were evaluated both before and after the drug layering for sphericity, aspect ratio, particle size distribution and friability. The novel maltodextrin/starch spheres either equaled or out-performed the more established sugar/starch and MCC spheres in each category. Continue Discussion of Processes which utilize Conical Rotor Technology To develop and introduce several novel processing methods which can be done with conical rotor technology. These methods include spherical granulation, powder layering, and solution/suspension coating. Continue Evaluation of a Process to Quickly and Efficiently apply Dry Polymer to Acetaminophen Beads using a Rotor Processor To develop a method to quickly and efficiently coating dry polymer onto beads using rotor processing without the use of organic solvents. Continue Optimization of Controlled Release Granule Properties by Screw Design in a Continuous Granulation System Challenges exist in developing a robust continuous twin screw granulation process. One of the past challenges encountered has been the formation of “noodle-like” granules at the end of the extruder. Continue Using Continuous Granulation to Make Robust and High Drug Load APAP Granules Since most pharmaceutical ingredients (API) have low density and poor flowability, wet granulation is practiced extensively for ease of handling. Wet granulation can be achieved by means of high shear mixers, fluid beds and twin-screw granulators. Continue Wurster Coating PAT Monitoring by NIR: Calibration vs PCA Trend Approach To follow the wurster coating process trend using NIR technology and to determine realtime the deviations from the correct process path. Continue Drying PAT Monitoring by NIR: Calibration vs PCA Trend Approach To determine the endpoint for drying using NIR technology. To establish the correlation between the Moisture Content of the mixture and the response of the NIR device. To find a mathematical and statistical approach to the in-process control using derivative method, PCA calculation and trend approach. Continue Enteric Coating of Multi-Particulates with Dry Powder Application of Glidant Utilizing a Modified Wurster Spray Gun System Bottom Spray Wurster technology is commonly used in the pharmaceutical industry as a method for applying active and functional coatings, including sustained release and enteric polymer coatings, to multi-particulate substrates. Typically aqueous dispersion of polymers are diluted and are mixed with appropriate glidant, such as talc, to reduce blocking and agglomeration during the drying of the polymer solution on the surface of the multi-particulate. These solutions and suspensions are applied via air atomizing spray guns. The need to dilute the solution can increase the application time needed for proper drug release or enteric protection. Continue Evaluation of a Novel, High Solids, Film-Coating System for Temperature Sensitive Products Processing heat sensitive products below body temperatures with aqueous based coating solutions is challenging. HPMC or PVA based coating formulations typically require film forming temperatures above 40°C. The goal of this study was to evaluate the coating quality of a modified, starch based polymer utilizing various solids percentages at process bed temperatures lower than 35°C for different tablet compositions and batch loads. Continue Novel Dry Powder Application of Anti-Tack Agent Utilizing a Modified Wurster Spray Gun System Bottom Spray Wurster technology is commonly used as a method for applying functional coatings to multi-particulate substrates. Typically, antitack agents are added to dilute solutions or suspensions of polymer to reduce blocking during the drying of the polymer coat. Having to add antitack agents to the solution can create sedimentation and plugging in the solution lines. This study focuses on the scaling ability of a modified Wurster gun process to efficiently coat multi-particulate cores utilizing a polymer solution without anti-tack agents in solution, but with the anti-tack agents added via dry powder application through the modified Wurster spray gun. Continue Top Spray Granulation PAT Monitoring by NIR: Calibration vs. PCA Trend Approach To determine the endpoint for Top Spray Granulation using NIR technology. To establish the correlation between the Moisture Content (expressed as Loss on Drying), the Particle Size Distribution (PSD) of the mixture and the response of the NIR device. To find a mathematical and statistical approach to the in-process control using derivative method, PCA calculation and trend approach. Continue Post navigation OLDER POSTS ® Copyright 2021 Freund-Vector Corporation PRIVACY POLICY FREUND WEB SITE 675 44TH STREET MARION, IA 52302 +1-319-377-8263 Home