Recursion OS Approach Impact Pipeline Partners Investors About Careers Recursion OS Approach Impact Pipeline Partners Investors About Careers The Recursion Operating System. Turning drug discovery into a search problem Central to our mission is the Recursion Operating System (OS), an integrated, multi-faceted system for generating, analyzing and deriving insight from massive biological and chemical datasets to industrialize drug discovery composed of: Infrastructure Layer of enabling hardware and software The Recursion Data Universe, which houses our diverse and expansive datasets The Recursion Map, a suite of proprietary discovery, design, and development tools Combined, the Recursion OS enables us to explore foundational biology unconstrained by human bias, navigate to new biological insights, and rapidly accelerate programs. Our People & Culture transcend the entire OS as the fuel that brings it to life. Infrastructure Layer ‍ ‍The foundational layer of the Recursion OS is a highly-synchronized network of enabling hardware and software used to design, execute, aggregate and store 11 petabytes of rapidly growing biological and chemical data. We built the core elements of our infrastructure based on cutting-edge technology created in the last several years and continue to adopt new technological advancements within each component. ‍ The components of our infrastructure layer include: Recursion Data Universe Our proprietary collection of highly relatable, high-dimensional biological and chemical datasets spanning multiple different data modalities. These different data sets are highly complementary as we advance drug discovery and development programs. Phenomics Cellular microscopy images that capture composite changes in cellular morphology Orthogonomics Scaled transcriptomic and proteomic datasets used to validate the activity of compounds and further elucidate the mechanism by which drug candidates may be acting Bespoke One-Off Assays Custom assays for program-specific validation ADMET Assays Large-format absorption, distribution, metabolism, excretion, and toxicology data that enable us to identify and predict early liabilities InVivomics Sensor data and continuous video feeds from cameras embedded in custom animal study cages and used to collect more holistic measurements of animal behavior and create abstract representations of in vivo disease states Recursion Map A rapidly growing suite of in-house software applications designed to process and translate data from the Recursion Data Universe into actionable insights for our research and development teams to accelerate programs. These tools cover a broad set of uses including: Data Processing Tools to manage and monitor the streaming of data to the cloud at scale, transform our images into mathematical representations through our in-house proprietary convolutional neural networks, and perform standard and custom analyses Biological and Chemical Activity Assessment Scaled transcriptomic and proteomic datasets used to validate the activity of compounds and further elucidate the mechanism by which drug candidates may be acting Program Insight Tools that translate processed data into actionable insights, enabling us to infer tens of billions of relationships among biological and chemical perturbations Program Acceleration Tools that equip our teams with valuable information as they optimize therapeutic starting points into viable drug candidates, including in silico hit expansions based on 3D virtual screens and dense structure activity relationships as well as tools to augment in vivo experimentation Program Insight in action Central to this suite of tools is our PhenoMap, with which we can infer billions of relationships in silico among thousands of diverse biological perturbations, including CRISPR gene knockouts, soluble factors, viruses and hundreds of thousands of small molecules that have been screened on our platform. These relationships can be used to inform novel drug targets or early therapeutic compounds to start new discovery programs. Program Acceleration in action Scaffold Shopper can compare candidate compounds identified by our platform to over 12 billion ready-to-synthesize and off-the-shelf molecules based on our 3D chemical functionality and shape-based similarities, within a matter of minutes and at low computational expense. ‍ By applying the Recursion OS to drug discovery, Recursion expects to turn drug discovery from sequential trial-and-error into a search problem. Proud founding member of BioHive, the fastest growing life sciences community in the nation Get In Touch 41 S Rio Grande Street Salt Lake City, UT 84101 phone: (385) 269-0203 fax: (801) 821-2872 info@recursion.com Investor Relations Connect LinkedIn Twitter Youtube