A proprietary process to identify small molecules for activating progenitor cells Discovery in the right context Traditional drug screening uses cells that may not reflect the complex biology of tissue-specific cell types in the body, especially for progenitor cells. We develop primary progenitor cell assays that are designed to maintain these cells in their natural state to increase the likelihood of successful drug discovery and translation into an effective, tissue-specific therapeutic. Decoding and controlling activation pathways for progenitor cells Using our insights into progenitor cell signaling and aging, we work to identify biological pathways that may activate a specific progenitor cell. We then select and apply proprietary small molecules to modulate the chosen biological pathways to activate these progenitors. Using these small molecules, we and our collaborators have applied this discovery process to identify compounds that activate progenitor cells in numerous tissues. As each tissue is unique in its biological needs, our approach allows for the development of treatments for specific tissue ailments throughout the body. Our strategy is to use this approach to deliver new therapeutics in indications beyond hearing loss, starting with multiple sclerosis. Interested in joining our team? Explore careers © 2021 Frequency Therapeutics Open Positions Contact Privacy Policy Terms & Conditions

Sound Clarity and Speech Perception I can hear you, but I can’t understand you. Healthy hearing is much more than the audibility (loudness) of sound. Sound clarity and speech perception, or understanding speech and recognizing words, are just as important. The inner ear is lined with two types of cells called “hair cells” – inner hair cells and outer hair cells. Outer hair cells are responsible for amplifying, tuning and filtering sounds, while inner hair cells convert sounds into electrical signals carried to the brain. The loss of either cell types leads to a decrease in sound sensitivity, clarity and intelligibility. Critical information lost at high frequencies Today’s treatments for hearing loss – amplifying devices such as hearing aids – are limited in their ability to improve speech perception and clarity, as they cannot replace the tuning and filtering of lost hair cells. This often translates into difficulties understanding speech and following conversations – often in noisy backgrounds. Additionally, most acquired SNHL begins in the high frequencies (2,000 Hz to 8,000 Hz). High frequency hearing loss is associated with problems understanding speech, because a lot of speech sounds – especially “s,” “f” and “th” – are high frequency, soft sounds. When you can’t hear these consonants, it can be very difficult to recognize words. Add all this together, and millions of people with hearing loss continue to struggle with speech perception, even when using assistive devices. Interested in joining our team? Explore careers © 2021 Frequency Therapeutics Open Positions Contact Privacy Policy Terms & Conditions