<span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start">﻿</span> Our Mission To create value for our customers by accelerating and reducing the costs of R&D through innovative science-based software and consulting solutions that optimize treatment options and improve patient lives. Celebrating 25 years in business and continuing the commitment to improve public health through innovative solutions! We are a leading provider of modeling and simulation software and consulting services supporting drug discovery, development research, and regulatory submissions. With our subsidiaries, Cognigen, DILIsym Services, and Lixoft, we offer solutions that bridge machine learning, physiologically based pharmacokinetics, quantitative systems pharmacology/toxicology, and population PK/PD modeling approaches. Our technology is licensed and applied by major pharmaceutical, biotechnology, chemical, consumer goods companies, and regulatory agencies worldwide. Read about our Vision, Mission, and Values 2021 March 3, 2021 Hosts The Inaugural 2021 MIDD+ Scientific Conference Enlarge Simulations Plus hosts the Inaugural 2021 MIDD+ Scientific Conference with over 50 Model-Informed Drug Development Sessions. Read More 2020 September 15, 2020 Releases ADMET Predictor® Version 10.0 (APX™) Enlarge Simulations Plus released version 10.0 of its flagship machine learning modeling platform, ADMET Predictor®, The new release is marketed as APX™ on September 2020. Read More August 10, 2020 Simulations Plus Raised About $115 Million Underwritten Public Offering of Common Stock Enlarge Simulations Plus announced underwritten public offering of 2,090,909 shares of its common stock to the public at $55.00 per share. Learn More April 1, 2020 Lixoft becomes a subsidiary of Simulations Plus Enlarge Lixoft becomes a wholly owned subsidiary of Simulations Plus on April, 2020. Lixoft is design software solutions based on scientific breakthroughs to reduce the cost and increase the success rate of new drug development. Learn More January 6, 2020 Grace Fraczkiewicz Celebrates 20 Years of Service Enlarge In January 2020, Grace Fraczkiewicz celebrated her 20 years of service with Simulations Plus. Read About her Journey 2018 August 6, 2018 Robert Fraczkiewicz Celebrates 20 Years of Service Enlarge In August of 2018, Robert Fraczkiewicz celebrated his 20 years of service with Simulations Plus. Read About his Journey June 26, 2018 Simulations Plus Names Shawn O’Connor as CEO Enlarge Shawn M. O’Connor appointed as Chief Executive Officer(CEO) effective from June 26, 2018. Learn More February 1, 2018 S+pKa Model Wins SAMPL6 pKa Challenge Enlarge Predictions of ionization constants performed by the S+pKa method implemented in ADMET Predictor™ software wins SAMPL6 pKa challenge on February 2018. Learn More 2017 June 1, 2017 DILIsym Services, Inc. Becomes a Subsidiary of Simulations Plus Enlarge DILIsym becomes a wholly owned subsidiary of Simulations Plus. DILIsym is the global leader in the simulation of drug-induced liver injury (“DILI”). Learn More 2016 October 10, 2016 Jill Fiedler-Kelly Named Fellow of ISoP Enlarge Jill Fiedler-Kelly awarded with ISoP Fellowship for her professional excellence and superior impact in pharmacometrics, and for substantial volunteering work for ISoP on October, 2016. Learn More August 25, 2016 Simulations Plus Releases PKPlus™ Version 1.0 Enlarge Simulations Plus released version 1.0 of PKPlus™, its next-generation software for analysis of preclinical and clinical trial data. Learn More 2014 December 9, 2014 First Commercial Simulx Version Enlarge Lixoft released version 1.0 of Simulx, an easy, efficient and flexible application for clinical trail simulations, on December 2014. Learn More October 21, 2014 MembranePlus™ Version 1.0 Released Enlarge Simulations Plus announced that it has expanded its product portfolio with the release of version 1.0 of its MembranePlus™ simulation software on October 2014. Learn More September 2, 2014 Cognigen Corporation Becomes a Subsidiary of Simulations Plus Enlarge Cognigen became a wholly-owned subsidiary of Simulations Plus on September 2014. Learn More July 7, 2014 Joel and Jill published “Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models” Enlarge Joel S. Owen and Jill Fiedler-Kelly published a textbook on “Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models” on July 2014. Read More 2013 March 4, 2013 Ted Grasela Awarded With The Gary Neil Prize from ASCPT Enlarge Dr. Grasela was awarded the Gary Neil Prize for Innovation in Drug Development from the American Society for Clinical Pharmacology and Therapeutics(ASCPT). Learn More 2012 January 9, 2012 DILIsym® Version 1A Released Enlarge DILIsym® Version 1A was released on January 2012. Learn More 2011 October 3, 2011 First commercial Monolix® Version 1.0 Enlarge Monolix® Version 1.0 was released on October 2011. Learn More 2009 July 7, 2009 Simulations Plus Named to Fortune Small Business FSB 100 List Enlarge Simulations Plus has been named to the ninth annual Fortune Small Business FSB 100 list of the fastest-growing small public companies in America. Learn More 2005 February 9, 2005 DDDPlus™ 1.0 Released Enlarge Simulations Plus released version 1.0 of DDDPlus™, a simulation of in vitro dissolution experiments for formulation scientists in the pharmaceutical industry on February 2005. Learn More January 4, 2005 ADMET Predictor™ 1.0 Released Enlarge Simulations Plus released version 1.0 of ADMET Predictor™, formerly known as QMPRPlus™ on January 2005. Learn More 1999 July 1, 1999 Simulations Plus Listed on The NASDAQ Enlarge In 1999, Simulations Plus listed on the NASDAQ (American Stock Exchange) under the symbol SLP. 1998 July 1, 1998 GastroPlus® Version 1.0 Released Enlarge Simulations Plus releases its flagship PBPK modeling and simulation, GastroPlus®, in July 1998. Learn More 1996 July 1, 1996 Simulations Plus Incorporated in Lancaster, California Enlarge Simulations Plus incorporated in Lancaster, California in July 1996. Previous "Just wanted to drop a quick note and take the opportunity to highlight the excellent software application support the team has provided for GastroPlus. I really don’t think I would have got to where we have on my own but feel much better positioned now to use some of these additional features in the software. The team has excellent customer focus, and I really like the style and manner in which you interact with the user." -- Lead Specialist Next SOFTWARE ADMET Predictor® DDDPlus™ DILIsym® GastroPlus® IPFsym™ MedChem Designer™ MembranePlus™ MonolixSuite® NAFLDsym® RENAsym SERVICES Global Regulatory Strategies Liver Safety Modeling and Analysis Noncompartmental PK/TK Analysis PBPK Modeling and Simulation PK/PD Support PopPK & Exposure Response Modeling QSP Modeling of NAFLD & NASH Training and Workshops RESOURCE CENTER Blog Contact Support GastroPlus User Group Journal Articles PKPlus User Group Posters Product Brochures Software Installation Videos Webinars INVESTORS Board of Directors ESG Report Latest Presentations Press Releases SEC Filings Shareholder Information ABOUT Simulations Plus Contact Career Opportunities Leadership Partners and Collaborators Privacy Policy Vision, Mission & Values Events INDUSTRIES Chemicals Deep Machine Learning & Technology Food/Cosmetic Pharma + Biotech  © 2021 Simulations Plus. 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