Careers Search for: Biology Chemistry Manufacturing About Us Contact Us Drug Conjugate and Payload Characterisation Research Services and Technologies / Bioassays / Drug Conjugate and Payload Characterisation Drug-conjugate and payload characterisation Abzena provides you with a toolbox of biological assays to support your payload and drug conjugate development. All our assays have been established using clinical benchmarks and can be applied from lead identification, to lead characterisation and benchmarking. Viability & Cytotoxicity Assays Viability and cytotoxicity are the primary potency readouts for payloads and drug conjugates. Read more >>> Fc Binding & Function Assays Some ADCs maintain Fc-mediated functions, such as complement or immune cell-mediated lysis of antigen expressing cells. Toxicities observed have also been linked to binding of ADCs to healthy cells via their Fc domain, highlighting the relevance of such assays. Read more >>> Pgp Assays A Pgp assay is often the first approach when interrogating the susceptibility of a new payload to drug resistance. Read more >>> Tubulin Polymerisation Assays A biochemical tubulin polymerisation assay has been set up to confirm the mode of action of free payloads interfering with tubulin polymerisation. Read more >>> Bystander Assays The ability of a drug conjugate at not only targeting antigen-positive cells but also the neighbouring antigen-negative cells is called bystander effect. Read more >>> Internalisation and Trafficking Assays The value of internalisation and intracellular trafficking assays has been established throughout the development of a drug conjugate, from selecting a suitable targeting moiety, to confirming compound uptake by cells. Read more >>> Mode of Actions Assays Various assays can be used to investigate the effect of a payload or a drug conjugate on cells in more details. Cell cycle analysis and apoptosis assays have been established but assays specific to the mode of action of your compound can be developed. Binding and Competition Confirming that target binding is not altered by conjugation of a payload to a protein is essential. Read more >>> Interested in our services? Get In Touch Quick Links Home Careers Media Contact Us Contact Details Enquiries Cambridge, UK Babraham Research Campus Cambridge CB22 3AT United Kingdom +44 1223 903498 San Diego, CA, USA 8810 Rehco Rd San Diego CA 92121 United States +1 858-550-4094 Bristol, PA, USA 360 George Patterson Blvd. Bristol PA 19007 United States +1 215-788-3603 © Abzena Ltd | Registered Number: 08957107 | VAT Number: 125470235 Terms & Conditions | Complaints Policy | Cookie Policy | Privacy Policy