Careers Contact Services Publications Content News & Events About In Vivo Toxicology In Vitro Toxicology In Vivo Toxicology Pathology & Histology Genetic Toxicology Toxicogenomics Computational Toxicology The ILS In Vivo Toxicology team conducts pre-clinical safety and efficacy studies to meet regulatory requirements and non-GLP investigative studies supporting discovery research. ILS routinely provides regulatory toxicology testing in rodent species to comply with OECD, FDA and EPA test guidelines and meet US FDA, US EPA, ICH and worldwide regulatory agency requirements. We utilize the latest genomic profiling techniques to investigate mode-of-action and risk assessments, and regularly integrate services with other ILS teams to support in vivo toxicogenomic studies. We have extensive experience in designing, conducting, evaluating and interpreting study results that cover various endpoint analyses (toxicology, pathology, biochemical and molecular), and can draw on the full range of ILS services from genetic and in vitro toxicology to pathology and histology. Which means we can efficiently get you the data you need, in the format you require (including eCTD compliant reports and SEND compliant datasets), so you can make timely and fully informed decisions regarding mode-of-action and potential adverse effects and relevance to humans. In addition to traditional regulatory toxicology studies, ILS also designs in vivo toxicogenomic studies that include dose-response and bioinformatics, to determine differentially expressed genes and genomic response pathways, and derive benchmark dose used in risk assessments. CASE STUDY A toxicogenomics approach to assess MOA using next-generation sequencing More CASE STUDY Expedited in vivo micronucleus/comet supporting combined OECD 474/489 More CASE STUDY Investigational toxicology – challenging route of administration More General in vivo toxicology services Investigative toxicology services Necropsy and tissue/sample collection Animal models Special studies Relevant Publications Copyright 2018 Integrated Laboratory Systems | All Rights Reserved