Products Area of Interest Resources Support Company Careers In Situ Analysis Technology Localize single molecule RNA and protein in tissue Visualize and map genes at high sensitivity and subcellular resolution in situ In Situ analysis allows researchers to enhance and refine spatial transcriptomics data by creating targeted gene expression maps at cellular and subcellular resolution on tissue sections. By finely mapping complex cellular relationships and networks, biological processes leading to disease can be more clearly elucidated. Already, this technology has contributed to new insights into cell atlassing, neurodegenerative disease, immunology, and cancer. Map Cellular Relationships Finely map spatial information at the cellular and subcellular level, zooming in on targeted genes of interest. Preserve Tissue Morphology Simultaneously detect gene and protein expression from fresh-frozen, fixed-frozen, and FFPE tissue, and map the data to an H&E image. Complements Spatial and Single Cell Data Complement and refine your Visium spatial transcriptomics and/or single cell data to dive deeper with a robust, highly sensitive, and specific in situ end-to-end workflow. Key Features Optimized chemistry and integrated hardware provide an end-to-end solution with highly resolved spatial outputs that can be analyzed using our software and visualization tools Capable of interrogating RNA targets simultaneously with proteins on the same tissue section with high sensitivity and specificity at subcellular resolution Extremely flexible solution that enables the use of one of our pre-designed panels, with the option to customize Enough throughput to enable high-power biological studies and pre-clinical cohort–based design Publications Cellular relationships revealed: From development to health and disease See how researchers are applying in situ analysis to map cellular relationships and dive deeper into spatial transcriptomic data. Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease Chen et al. Cell. 2020. Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma Carow et al. Nature Communications. 2019 A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart Asp et al. Cell. 2019 Product Availability 10x Genomics is currently investing in development of the future In Situ analysis technology by combining the strengths of Cartana and ReadCoor technologies. For inquiries or to be added to our interest list, please sign up below. Contact Us ABOUT Products Platform Company Careers Contact Employment Verification LEGAL NOTICES Privacy Policy Terms of Use Email Preferences Other Legal Notices HEADQUARTERS +1 925 401 7300 +1 800 709 1208 info@10xgenomics.com RESOURCES Publications Support Videos SOCIAL SIGN UP FOR PRODUCT AND EVENT UPDATES Subscribe © 2021 10x Genomics. All Rights Reserved. English中文日本語