ABOUT COMPANY PRODUCTS DISTRIBUTORS PRESS CENTER SHAREHOLDERS NEWS CONTACTS ENGLISH QUESTION ANSWER LYSINOPRIL ORGANIC Active ingredient: lisinopril dihydrate. Pharmacological action: angiotensin-converting enzyme inhibitor (ACE), reduces the formation of angiotensin II from angiotensin I. Reduces total peripheral vascular resistance, blood pressure (BP), preload, pressure in the pulmonary capillaries, causes an increase in the minute blood volume and an increase in myocardial tolerance to stress in patients with CHF. ACE inhibitors prolong life expectancy in patients with CHF, slow down the progression of left ventricular dysfunction in patients who have had myocardial infarction without clinical manifestations of heart failure. Indications:arterial hypertension (in monotherapy or in combination with other antihypertensive drugs), chronic heart failure (as part of combination therapy for the treatment of patients taking cardiac glycosides and / or diuretics); early treatment of acute myocardial infarction in combination therapy; diabetic nephropathy. Method of administration and dosage:inside, 1 time per day in the morning, regardless of the meal, preferably at the same time. With arterial hypertension, with monotherapy - 5 mg 1 time per day. If there is no effect, the dose is increased every 2-3 days by 5 mg to an average therapeutic dose of 20-40 mg / day. The usual daily maintenance dose is 20 mg. The maximum daily dose is 40 mg. In case of insufficient therapeutic effect, it is possible to combine the drug with other antihypertensive drugs. In renal failure: the initial dose for creatinine clearance (CC 30-70 ml / min) is 5-10 mg / day, 10-30 ml / min - 5 mg / day, less than 10 ml / min, (including hemodialysis - 2.5 mg / day). With CHF: the initial dose is 2.5 mg per day, with a gradual increase in 3-5 days to 5-10 mg per day. The maximum daily dose is 20 mg. Early treatment of acute myocardial infarction (as part of combination therapy): in the first 24 hours - 5 mg, then 5 mg every other day, 10 mg every two days and then 10 mg once a day. The course of treatment is at least 6 weeks. For diabetic nephropathy: the initial dose is 10 mg / day, which, if necessary, is increased to 20 mg / day to achieve the target diastolic blood pressure. Contraindications: according to the instructions. Adverse reactions: according to the instructions. Special instructions: caution is required when prescribing to patients with bilateral renal artery stenosis or stenosis of an artery of a single kidney, patients with coronary artery disease or cerebrovascular disease, with decompensated CHF. In patients with CHF, arterial hypotension that occurs can lead to a deterioration in renal function. Before starting treatment, it is necessary to compensate for the loss of fluid and salts. It is necessary to control the effect of the initial dose of the drug. Release form: tablets of 5 mg and 10 mg. Before use, consult a doctor. For more information, see the instructions for use.