Share page on Facebook Share page on Twitter Share page on LinkedIn Home Insights Transforming Trials Decentralised & hybrid clinical trials Decentralised & hybrid clinical trials Patient focused research for better outcomes In-Home Services Bring your clinical trial directly to patients when and where it's convenient for them to reduce patient burden and increase recruitment and retention. Agile clinical monitoring: remote, on-site and centralised monitoring Monitoring strategies based on risk analysis and assesment for more resilient operations. mHealth and wearables management Understand the complexities of implementing wearable devices and harnessing digital endpoints in trial design, execution and reporting. With the rising cost and time to bring new drugs to market and more recently the pandemic outbreak, the demand for decentralised and hybrid trials has risen. These alternative trial models can range in shape and form to include digital health technologies, in-home clinical visits and remote monitoring. Practical considerations in transitioning to hybrid or decentralised clinical trials Everyone is talking about decentralised clinical trials. But how can we leverage what we learnt during 2020 and move forward in a more systematic way to deploy this approach with maximum efficiency and optimum results? Read the whitepaper Biopharma perspective: The promise of decentralised models and diversity in clinical trials ICON invited senior biopharma executives to discuss how decentralised and hybrid clinical trial models can provide increased resilience and to share how their respective organisations are currently or likely to address diversity and inclusion in clinical trials going forward. This summary report outlines how these executives see the opportunity in the developments of 2020, paving the way for continuous improvements into the future. Read the summary report Patient insight - decentralised & hybrid clinical trials Engaging patients more fully and making sure decentralised clinical trials are easing rather increasing burden is going to be crucial to using these models in the longer term. Early in 2021, ICON conducted a survey to compare it to one conducted in 2019 to see if the COVID-19 outbreak had changed the sentiment and increased interest in participating in clinical trials remotely. Read the survey results In-home services in decentralised clinical trials Bringing clinical trial visits to patients in their homes decreases burden and leads to higher enrollment rates. Explore the benefits and solutions to overcome perceived barriers so that you can provide this as an option on your next trial. Read the whitepaper Building resilience in pharma R&D by decentralising and digitising The COVID-19 outbreak has driven the desire for more resilient clinical trials. The deployment of remote clinical monitoring is proving its value in helping to keep trials going at a time when site management is particularly challenging. But realising this transformation requires a flexible mindset, investment in new technologies and close collaboration between stakeholders. Access the webinar recording Advancing digital endpoints Although mHealth devices and sensors are continuing to evolve, and it is now possible to capture a vast array of physiological data, the operationalisation of digital trials is not without challenges. Navigate the shift from traditional trial models to agile, patient-centric processes driven by digital health technologies. Read the whitepaper Agile clinical monitoring During COVID-19 the levels of remote monitoring increased due to site closures and safety reasons. Now is the time to learn from that experience and review whether a hybrid model of remote monitoring and centralised monitoring is the way forward for some trials. Learn best practices in analysing and assessing risk in clinical monitoring and how to remain agile adapting to environmental conditions and therapeutic focus. Read the whitepaper Accellacare In-Home Services Bringing the trial to the patient: Webinar: In-home visits in clinical trials Factsheet: In-Home Services to reduce patient burden Case study: Expanding geographic reach in rare disease study Case study: Special populations and procedures for maternal and infant studies mHealth & wearables Understand how to implement wearable devices and harness digital endpoints in clinical trials: Webinar: The template for implementing a successful digital trial Factsheet: Wearables and digital endpoint validation Case study: Wearables and remote monitoring: Quantifying cough with sensor technology Case study: Conducting a trial in a community setting: The REACHES study Decentralised and hybrid trials blogs Real-time monitoring of the digital patient in clinical trials The collection of real-time data in a home setting can give sponsors and trial managers greater visibility and assurance around GCP and protocol compliance. Wearables across phases How to best incorporate digital endpoints at every stage of clinical research. Wearables and digital endpoint generation An end-to-end approach to managing wearable devices through clinical development. Decentralised and hybrid trials videos Play Video Now Playing 3:15 18:36 2:45 25:50 1:32 Receive more insights on decentralised & hybrid clinical trials from ICON Please visit ICON's Preference Centre and select 'Decentralised & Hybrid Clinical Trials' under 'Patient Centricity' to receive new insights on decentralised & hybrid clinical trials. Receive new insights Decentralised and hybrid trials media contributions Decentralised Clinical Trials and Real World Evidence In this video interview, Kim Boericke, President, Commercialization and Outcomes Services, discusses what is driving a great focus and intensity on outcomes in clinical trials, trends coming in 2022, and the use of real-world data and the rare disease space. Operationalising decentralised clinical trials In this article, our experts discuss the challenges and change management approaches that ICON faced during the COVID-19 pandemic, and how we overcame them through the use of decentralised and hybrid clinical trials. Video series: The 3 "Cs" of the data journey This three part video series examines some of the factors that should be considered to ensure that clinical trial data captured via wearable devices, is monitored expeditiously and effectively. The waterfall effect of digital health technology on unifying healthcare and clinical research Isaac R Rodriguez-Chavez contributes to the DPHARM Autumn 2021 newsletter, discussing the use of digital health to maximise efficiencies in decentralised clinical trials. CROs: Yesterday, today and tomorrow ICON's Kent Thoelke discusses today’s key trends for CROs, including the increasing adoption of decentralised clinical trials (DCTs) and the growing use of remote monitoring to collect data. Ensuring better patient outcomes through decentralised trials The research industry has changed in the past year, and decentralised models are helping to improve patient outcomes and bring treatments to market faster (page 12). Practical considerations when deploying a decentralised or hybrid clinical trial A discussion around the key components of decentralised trials and steps of deployment. Pragmatic steps to using mobile technology in clinical trials Wearables and other mobile technologies are increasingly recognised as drivers of democratisation and diversification in clinical trials. Will COVID-19 bring lasting change in clinical trial practices? COVID-19 may be the inflection point that tips clinical trial practices into the digital age. eBook: Digital acceleration in clinical trials Digital health has been a hot topic for many years, but it has taken the pandemic to really highlight its value across many areas of the pharma and biotech industries. Decentralised, hybrid or traditional Choosing the best option for your clinical trial. Wearables in virtual clinical trials Wearables are improving the clinical trial experience for patients and satisfying the need to collect data for real-world use studies. Pfizer COVID vaccine trial proved remote monitoring and other innovations work Starting clinical trials in weeks, as opposed to months, should be possible post-pandemic. Bringing the trial to the patient Reducing the burden that clinical trial participation places on patients can help to keep patients engaged in clinical research. Mapping the patient journey and minding the gap Seven steps to closing the gap between rhetoric and reality in patient-centricity. Patient centricity Exploring the patient perspective from different angles. Thwarting cyber attacks Steps to implement security into mHealth development. The power of patients Patient engagement is permeating all spheres of the healthcare ecosystem. Decentralising research Revolutionising clinical trials with wearables and digital endpoints. Listening to the patient for better outcomes Project teams need to be challenged constantly to justify the study procedures and eligibility criteria they are proposing. True patient-focused research through decentralised and hybrid trials How can pharma improve the patient centricity of its trials during COVID-19 and beyond? ICON's solutions in decentralised and hybrid clinical trials Decentralised and hybrid trials bring a wide range of benefits to the patient and the sponsor. Find out more about the range of decentralised and hybrid trials services available from ICON. 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