≡ YOU ARE HERE HOME » SCIENCE » TECHNOLOGY AREAS PROTEOMICS The Broad’s Proteomics Platform develops and applies advanced proteomics methods to further our understanding of disease, pathways, targets, and drug effects. The Proteomics Platform provides best-in-class mass spectrometry-based proteomic technologies and analysis capabilities to the Broad community and collaborators throughout the United States and beyond, with the goal of addressing important questions in biology, chemistry, and clinical sciences through intensive collaboration. We continue to adopt and pioneer development of cutting-edge sample processing, data collection, and data analysis technologies of greatest importance. Major areas of focus include: Multi -omic and proteogenomic studies of a wide range of cancers, metabolic, and infectious diseases providing detailed views and understanding of cellular signaling networks related to protein phosphorylation, ubiquitylation, acetylation, and cross-talk defining the targets of drugs or identifying protein interactors through chemical proteomics technologies and affinity purification mass spectrometry developing biological understanding of response and resistance to therapy improving understanding of immune biology and help develop personalized immunotherapies through analysis of HLA class I and II peptides inventing and optimizing proteomic technologies, automation methods, and computational analyses to increase speed, sensitivity, and completeness of proteome and post-translational modification data, and to improve the ability to extract new knowledge therefrom Together, these developments have enabled us to apply for and participate in numerous grant opportunities that leverage our novel capabilities, capacity, and throughput to provide a systems-wide and systematic approach to biology and necessary follow-up to genomic discoveries. We wish to acknowledge ongoing support via grants from the National Institutes of Health, the National Cancer Institute, and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation among others. PROTEOMICS About Contact How to Establish a Collaboration People Proteomics Facility Recent Publications Resources AREAS OF FOCUS Complexes: membership, stoichiometry and dynamics Epigenetics: Histone PTMs Disease biomarker discovery and verification Drug mechanism of action and target ID HLA peptide analysis Proteogenomics Posttranslational modification analysis Rare cell and biopsy-scale analyses Spatial Localization and micro-environment Signaling Targeted, quantitative assays in biology and medicine RECENT PUBLICATIONS Automating UbiFast for High-throughput and Multiplexed Ubiquitin Enrichment. Proteogenomic characterization of pancreatic ductal adenocarcinoma. A highly multiplexed quantitative phosphosite assay for biology and preclinical studies. Proteomic profiling dataset of chemical perturbations in multiple biological backgrounds. An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens. Other Proteomics Publications RELATED A MORE COMPLETE MOLECULAR PICTURE OF LUNG SQUAMOUS CELL CARCINOMA COME... Read More NEWS AT THE BROAD ALL NEWS NEWS / 10.12.21 René Salazar joins Broad Institute as Chief Equity Officer READ MORE NEWS / 10.28.21 A conversation about the legacy of ENCODE and what comes next READ MORE NEWS / 10.6.21 Single-cell exploration of the mouse brain reveals new cell type READ MORE NEWS / 10.6.21 Richard Merkin, M.D., renews support for transformative science at Broad READ MORE CAREERS GIVING NEWS AND MEDIA CONTACT US PRIVACY POLICY Copyright © 2021 Broad Institute. All rights reserved. TWITTER FACEBOOK YOUTUBE INSTAGRAM