About Research Publications Translational Research Center Contact DONATE Publications Publications Bibliography for research conducted at MMRI (as of January 2018) Welihinda AA, Kaur M, Raveendran KS, Amento EP. Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation. Cell Signal. 2018 Jan;42:227-235. PMID: 29126977. Welihinda A, Ravikumar P, Kaur M, Mechanic J, and Amento E. Adenosine A2A receptor (A2AR) modulation attenuates innate and adaptive immune cell signaling during pathogenesis of psoriasis-like dermatitis in mice. Journal of Investigative Dermatology, May 2017, Volume 137 , Issue 5 , S119. Abstract, Poster. Stewart DR. Relaxin Concentrations in Acute Heart Failure Patients. Rev Esp Cardiol (Engl Ed). 2017 Jun;70(6):516. PMID: 28109848. Madasamy S, Shivasubramani U, Villanueva J, Bigos M, Amento EP, Wu AH. Nonenzymatic Mechanism of Statins in Modulating Cholesterol Particles Formation. Am J Cardiol. 2016 Oct 15;118(8):1187-1193. PMID: 27614849. Welihinda AA, Kaur M, Greene K, Zhai Y, Amento EP. The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal. 2016 Jun;28(6):552-60. PMID: 26903141. Free PMC Article. Madasamy S, Chaudhuri V, Kong R, Alderete B, Adams CM, Knaak TD, Ruan W, Wu AH, Bigos M, Amento EP. Plaque array method and proteomics-based identification of biomarkers from Alzheimer’s disease serum. Clin Chim Acta. 2015 Feb 20;441:79-85. PMID: 25532947. Welihinda AA, Amento EP. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond). 2014 Nov 28;11(1):37. PMID: 25473378. Free PMC Article. Welihinda AA, Mechanic J, Amento, EP. Positive Allosteric Modulation of the Adenosine A2a Receptor Alters Inflammatory Cytokine Production and Alleviates Chronic Arthritis in Rats. Arthritis & Rheum. 2013; 65 (10): S946. Abstract. Welihinda, AA, Amento, EP. A Positive Allosteric Modulator of the Adenosine A2a Receptor Inhibits Pro-inflammatory Cytokine Production and Alleviates Arthritis. 11th Annual Discovery on Target: GPCR-based Drug Discovery. 2012 Welihinda, AA, Amento, EP. Allosteric Enhancement of the Adenosine A2a Receptor. Keystone Symposia: G Protein-Coupled Receptors: Molecular Mechanisms and Novel Functional Insights. 2012 Welihinda, AA, Amento, EP. Functional Characterization of an Allosteric Enhancer of the Adenosine A2a Receptor That Inhibits Pro-Inflammatory Cytokine Production. Arthritis & Rheum. 2011; 70: T603. Abstract. Welihinda, A, Amento, EP. Orally active TNF-α inhibitor mediates anti-inflammatory activity by potentiating adenosine A2a receptor signaling. Arthritis & Rheum. 2009; 60: S501. Abstract. Samuel CuS, Zhao C, Yang Q, Wang H, Tian H, Tregear GW, Amento EP. The relaxin gene knockout mouse: a model of progressive scleroderma. J Invest Dermatol. 2005 Oct;125(4):692-9. PMID: 16185267. Samuel CS, Zhao C, Bathgate RA, DU XJ, Summers RJ, Amento EP, Walker LL, McBurnie M, Zhao L, Tregear GW. The relaxin gene-knockout mouse: a model of progressive fibrosis. Ann N Y Acad Sci. 2005 May; 1041:173-81. PMID: 15956703. Dawson MI, Harris DL, Liu G, Hobbs PD, Lange CW, Jong L, Bruey-Sedano N, James SY, Zhang XK, Peterson VJ, Leid M, Farhana L, Rishi AK, Fontana JA. Antagonist analogue of 6-[3′-(1-adamantyl)-4′- hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest. J Med Chem. 2004 Jul 1;47(14):3518-36. PMID: 15214780. Samuel CS, Zhao C, Bond CP, Hewitson TD, Amento EP, Summers RJ. Relaxin-1-deficient mice develop an age-related progression of renal fibrosis. Kidney Int. 2004 Jun;65(6):2054-64. PMID: 15149318. Zhang Y, Dawson MI, Ning Y, Polin L, Parchment RE, Corbett T, Mohamed AN, Feng KC, Farhana L, Rishi AK, Hogge D, Leid M, Peterson VJ, Zhang XK, Mohammad R, Lu JS, Willman C, VanBuren E, Biggar S, Edelstein M, Eilender D, Fontana JA. Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog. Blood. 2003 Nov 15;102(10):3743-52. PMID: 12893763. Samuel CS, Tian H, Zhao L, Amento EP. Relaxin is a key mediator of prostate growth and male reproductive tract development. Lab Invest. 2003 Jul; 83(7):1055-67. PMID: 12861045. Samuel CS, Sakai LY, Amento EP. Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin. Arch Biochem Biophys. 2003 Mar 1;411(1):47-55. PMID: 12590922. Gonzalez AM, Gonzales M, Herron GS, Nagavarapu U, Hopkinson SB, Tsuruta D, Jones JC. Complex interactions between the laminin alpha 4 subunit and integrins regulate endothelial cell behavior in vitro and angiogenesis in vivo. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16075-80. PMID: 12454288. Samuel CS, Zhao C, Bathgate RA, Bond CP, Burton MD, Parry LJ, Summers RJ, Tang ML, Amento EP, Tregear GW. Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis. FASEB J. 2003 Jan;17(1):121-3. PMID: 12424226. Chang E, Yang J, Nagavarapu U, Herron GS. Aging and survival of cutaneous microvasculature. J Invest Deramatol. 2002 May;118(5):752-8. PMID: 11982751. Nagavarapu U, Relloma K, Herron GS. Membrane type 1 matrix metalloproteinase regulates cellular invasiveness and survival in cutaneous epidermal cells. J Invest Dermatol. 2002 Apr;118(4):573-81. PMID: 11918701. Free Article. Dawson MI, Hobbs PD, Peterson VJ, Leid M, Lange CW, Feng KC, Chen Gq, Gu J, Li H, Kolluri SK, Zhang Xk, Zhang Y, Fontana JA. Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1- adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity. Cancer Res. 2001 Jun 15;61(12):4723-30. PMID: 11406543. Yang J, Nagavarapu U, Relloma K, Sjaastad MD, Moss WC, Passaniti A, Herron GS. Telomerized human microvasculature is functional in vivo. Nat Biotechnol. 2001 Mar;19(3):219-24. PMID: 11231553. Dawson MI, Park JH, Chen G, Chao W, Dousman L, Waleh N, Hobbs PD, Jong L, Toll L, Zhang X, Gu J, Agadir A, Merchant JL, Bai L, Verma AK, Thacher SM, Chandraratna RA, Shroot B, Hill DL. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13- acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA- induced ZBP-89 in ODC inhibition. Int J Cancer. 2001 Jan 1;91(1):8-21. PMID: 11149424. Romero LI, Zhang DN, Cooke JP, Ho HK, Avalos E, Herrera R, Herron GS. Differential expression of nitric oxide by dermal microvascular endothelial cells from patients with scleroderma. Vasc Med. 2000;5(3):147-58. PMID: 11104297. Li H, Kolluri SK, Gu J, Dawson MI, Cao X, Hobbs PD, Lin B, Chen G, Lu J, Lin F, Xie Z, Fontana JA, Reed JC, Zhang X. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science. 2000 Aug 18;289(5482):1159-64. PMID: 10947977. Holmes WF, Dawson MI, Soprano RD, Soprano KJ. Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. J Cell Physiol. 2000 Oct;185(1):61-7. PMID: 10942519. Dawson MI, Jong L, Hobbs PD, Xiao D, Feng KC, Chao WR, Pan C, Fontana JA, Zhang XK. 4-[3- (5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists. Bioorg Med Chem Lett. 2000 Jun 19;10(12):1311-3. PMID: 10890153. Dawson MI, Hobbs PD, Jong L, Xiao D, Chao WR, Pan C, Zhang XK. sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity. Bioorg Med Chem Lett. 2000 Jun 19;10(12):1307-10. PMID: 10890152. Nevrivy DJ, Peterson VJ, Avram D, Ishmael JE, Hansen SG, Dowell P, Hruby DE, Dawson MI, Leid M. Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. J Biol Chem. 2000 Jun 2;275(22):16827-36. PMID: 10828067. Fontana JA, Dawson MI, Leid M, Rishi AK, Zhang Y, Hsu CA, Lu JS, Peterson VJ, Jong L, Hobbs P, Chao WR, Shroot B, Reichert U. Identification of a unique binding protein specific for a novel retinoid inducing cellular apoptosis. Int J Cancer. 2000 May 15;86(4):474-9. PMID: 10797258. Zhang Y, Rishi AK, Dawson MI, Tschang R, Farhana L, Boyanapalli M, Reichert U, Shroot B, Van Buren EC, Fontana JA. S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid. Cancer Res. 2000 Apr 1;60(7):2025-32. PMID: 10766194. Free Article. Le Q, Dawson MI, Soprano DR, Soprano KJ. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9;19(11):1457-65. PMID: 10723137. Gravallese EM, Manning C, Tsay A, Naito A, Pan C, Amento E, Goldring SR. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum. 2000 Feb;43(2):250- 8. PMID: 10693863. Lewis M, Amento EP, Unemori EN. Transcriptional inhibition of stromelysin by interferon-gamma in normal human fibroblasts is mediated by the AP-1 domain. J Cell Biochem. 1999 Mar 1;72(3):373-86. PMID: 10022519. Amento EP. Immunologic abnormalities in scleroderma. Semin Cutan Med Surg. 1998 Mar;17(1):18-21. PMID: 9512102. Greaves DR, Wang W, Dairaghi DJ, Dieu MC, Saint-Vis B, Franz-Bacon K, Rossi D, Caux C, McClanahan T, Gordon S, Zlotnik A, Schall TJ. CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. J Exp Med. 1997 Sep 15;186(6):837-44. PMID: 9294138. Publications authored by current MMRI scientific staff can be accessed through the Research Team page. Photo Credit: Jacqueline Macou, Pixabay Molecular Medicine Research Institute 428 Oakmead Parkway Sunnyvale, CA 94085 (408) 523-6260 | information@mmrx.org facebooklinkedinEmail| Terms of Use Website by Colombo Designs