(0) Cancer Related Products TotalSeq™ antibodies LEGENDplex™ assays GoInVivo™ products Go-ChIP-Grade™ reagents Related Pages Immunotherapy Immuno-Oncology Cell Cycle Epigenetics Technical Protocols Cancer biology is broad and complex, as the causes and controls for cancer span a diverse range of biological processes, including cell cycle, epigenetics, angiogenesis and immunology. BioLegend provides solutions for advancing all aspects of cancer research, from elucidating the basic science of tumorigenesis to the development of novel immunotherapies. Find antibodies, multiplex assays, in vivo reagents, and resources to investigate individual research areas or connect multiple concepts. Request a Poster Cancer Biology Areas Applications Website Resources Angiogenesis Angiogenesis is the formation of new blood vessels that supply oxygen and nutrients to cells and tissues. Angiogenesis inhibitors are commonly used as cancer treatments because tumors that lack circulatory support have difficulty growing and spreading. Browse products for angiogenesis. Cancer Biomarkers Cancer biomarkers are molecules or proteins detectable in blood, tissues, or bodily fluids that indicate the presence or progression of cancer. Biomarkers like PD-L1, carcinoembryonic antigen (CEA), and lactate dehydrogenase can be used to assess the condition of the cancer and its response to treatment. Browse products for cancer biomarkers. Epigenetics Epigenetics is the study of the mechanisms that control DNA compaction and the accessibility of genes to transcriptional machinery. Aberrant modifications of DNA and histones, as well as dysfunction of histone deacetylases (HDACs), have been associated with tumor development. Browse products for epigenetics. Apoptosis and Tumor Suppressors Tumor suppressors are proteins that inhibit cell growth through mechanisms like cell cycle arrest, apoptosis induction, and blocking cell survival signaling pathways. Well characterized tumor suppressors include PTEN, Rb, and p53 – mutations in the genes that encode these proteins have been associated with cancers. Browse products for apoptosis and tumor suppressors. Cell Cycle The cell cycle controls the replication of cells, and its checkpoints are strictly regulated to prevent abnormal cell proliferation. Proteins like cyclins, cyclin-dependent kinases, and p53 play important roles in cell cycle progression or arrest, and their dysfunction can be associated with tumor growth. Browse products for cell cycle research. Immuno-oncology and Immunotherapy Immuno-oncology refers to the development of immunotherapies, which are immune-based treatments, for combating cancer. These include chimeric antigen receptor (CAR) T cells engineered to recognize cancer cells, checkpoint inhibitors like anti-PD-1 and anti-CTLA-4 antibodies, cytokines like interleukins and interferons, and therapeutic vaccines that prime the immune system to attack cancer cells. Immunotherapies have shown clinical efficacy in treating cancers, which has spurred the growth of immuno-oncology research. Browse products for immuno-oncology and immunotherapy. Tools World-Class Quality. Superior Customer Support. Outstanding Value. 8999 BioLegend Way San Diego, CA 92121 Tel: 877.246.5343 Copyright © 2021 BioLegend, Inc. All rights reserved. LEARN & SHOP Products Web Tools Explore & Learn Pathways Custom Products / Services Custom Panel Construction Promotions Literature GET HELP Technical Support Support Resources Ordering Questions Find a Distributor Contact Us Feedback ABOUT BIOLEGEND Company Careers Blog Privacy Policy Terms Cookie Preferences Tax Forms