04 Pipeline Our approach and platform are creating new possibilities in drug discovery Relay Therapeutics® is advancing a pipeline of promising therapeutic candidates designed to solve problems that were previously intractable or inadequately addressed with traditional drug discovery. Development Programs We have deployed our Dynamo platform to initially focus on the area of precision oncology. To date, we have generated several promising product candidates that address genetically or clinically validated targets that have previously been intractable or inadequately addressed. In addition, we are also advancing several early programs focused on other precision oncology and rare genetic disease targets. Program Discovery IND Enabling Phase 1 Phase 2 Phase 3 RLY-1971 SHP2 RLY-4008 FGFR2 RLY-2608 PI3Kα mutant Discovery Programs While our initial focus has been on enhancing small molecule therapeutic discovery in precision oncology, protein conformational dynamics are implicated in a wide variety of therapeutic areas. We are continuing to leverage the power of our Dynamo platform to further diversify our pipeline and have begun drug discovery programs focused on genetically validated targets in monogenic diseases. Current Discovery Programs Our current discovery programs are focused in targeted oncology and genetic disease. Potential Future Therapeutic Areas We also continue to evaluate potential additional therapeutic areas beyond precision oncology and genetic disease that we could enter in the future. Publications/ Presentations View All Publications Publication October 8, 2021 First Results of RLY-4008, a Potent and Highly Selective FGFR2 Inhibitor in a First-in-Human Study in Patients with FGFR2-Altered Cholangiocarcinoma and Multiple Solid Tumors Download Publication October 7, 2021 Discovery and characterization of RLY-2608, the first allosteric, mutant, and isoform-selective inhibitor of PI3Kα Download At Relay Therapeutics, we know that patients need new medicines now. This is the driving force behind everything we do. Learn More Who We Are Our Team Dynamo Platform Pipeline Patients Investors & Media Careers Contact Relay Therapeutics 399 Binney Street, 2nd Floor Cambridge, MA 02139 info@relaytx.com (617) 370-8837 © Relay Therapeutics 2020 Privacy Policy Terms of Use

Relay Therapeutics® 399 Binney Street, 2nd Floor Cambridge, MA 02139 info@relaytx.com (617) 370-8837 Google Map View For Media Inquiries: Katie Engleman 1AB katie@1abmedia.com For Investor Inquiries: Pete Rahmer prahmer@relaytx.com For Collaboration and Business Development Inquiries: bd@relaytx.com For Career Inquiries: See Our Job Postings Who We Are Our Team Dynamo Platform Pipeline Patients Investors & Media Careers Contact Relay Therapeutics 399 Binney Street, 2nd Floor Cambridge, MA 02139 info@relaytx.com (617) 370-8837 © Relay Therapeutics 2020 Privacy Policy Terms of Use