Cardiomyocyte Renewal Laboratory A RESEARCH DEPARTMENT AT THI Overview Our Team Our Department The future of preventing and treating heart disease The Cardiomyocyte Renewal Laboratory focuses on understanding how genetic pathways are connected to adult tissue homeostasis and regeneration. By obtaining an in-depth understanding of these pathways, the team hopes to develop treatments and techniques that will prevent disorders like heart failure and atrial fibrillation and develop new treatments to treat heart disease. LAB'S DISCOVERY SHOWCASED DR. JAMES MARTIN HAS A THEORY Dr. James Martin, Director of Texas Heart Institute’s Cardiomyocyte Renewal Laboratory, and his team in the THI lab with their collaborators have conducted groundbreaking work that is taking us one step closer to heart regeneration and renewal. The team’s research on genetic pathways has revealed important new knowledge about pathways and signals that cause the heart muscle cells to proliferate that restrict the heart’s ability to repair itself after injury. Their discoveries are allowing them to manipulate these cell signaling channels called the “Hippo pathway” and they have been able to trigger cardiomyocytes to multiply and essentially repair the scarred muscle, thus renewing the heart’s pumping function. Heart Regeneration Gene Editing Our Department The Cardiomyocyte Renewal Laboratory addresses major areas of disease-related research including heart failure and atrial fibrillation. Our Team Led by James Martin, MD, PhD, the lab’s groundbreaking studies have yielded exciting results, including discovering the genetic pathway that prevents the heart from regenerating after an injury. Recent News Genetic discoveries made by James F. Martin, MD, PhD and his colleagues unveils new insights critical to better understanding components of genetic pathways that enable cardiomyocyte self-renewal for cardiac repair. Heart Health Patient Care Research Education The Institute FIND A DOCTOR OUR PEOPLE THI NEWS EVENTS CONTACT CAREERS GIVING DONATE SEARCH THI RESOURCES Office of Research Administration Library & Learning Resource Center Scientific Publications & Grants Visual Communications & Public Affairs Information Technology Careers FOR MEDICAL PROFESSIONALS Continuing Medical Education Texas Heart Institute Journal THI Journal FOR THE PUBLIC Heart Information Center Project Heart Women’s Heart Health Clinical Trials 6770 Bertner Avenue Houston, Texas 77030 832-355-3792 © Texas Heart Institute All Rights Reserved WE CARE ABOUT YOUR PRIVACY Texas Heart Institute Vendors Texas Heart Institute Settings Purposes We and our partners can: Store and/or access information on a device Select basic ads Create a personalised ads profile Select personalised ads Create a personalised content profile Select personalised content Measure ad performance Measure content performance Apply market research to generate audience insights Develop and improve products Vendor Settings Purposes Vendors can: Store and/or access information on a device Select basic ads Create a personalised ads profile Select personalised ads Create a personalised content profile Select personalised content Measure ad performance Measure content performance Apply market research to generate audience insights Develop and improve products Special Purposes Vendors can: Ensure security, prevent fraud, and debug Technically deliver ads or content Features Vendors can: Match and combine offline data sources Link different devices Receive and use automatically-sent device characteristics for identification Special Features Vendors can: Use precise geolocation data Actively scan device characteristics for identification Some partners do not ask for your consent to process your data, instead, they rely on their legitimate business interest. Personal data processed includes but is not limited to cookies, IP addresses, and URLs visited. View our list of partners to see the purposes they believe they have a legitimate interest for and object to legitimate interests on a per vendor basis. Manage your settings and object to purposes as a legitimate interest in general. You can change your settings at any time, including by withdrawing your consent, by clicking on the cog icon in the bottom right hand corner. Manage Settings Vendors Accept All Reject All Save & Exit