Home Technologies Market Opportunity Product Portfolio Clinical Investors acura Contact Us Technology Platforms AVERSION® IMPEDE® LIMITX™ LIMITX™ Technology Limitx™ is a novel formulation of common pharmaceutical ingredients intended to address abuse by excess oral consumption of multiple tablets and provide a margin safety during accidental over-ingestion of tablets. Status In proof of concept laboratory tests, Limitx™ demonstrated the ability to limit the release of the active ingredient from tablets when multiple tablets are simultaneously introduced into simulated gastric fluid. Limitx™ is being developed by Acura pursuant to a grant from the National Institute On Drug Abuse (“NIDA”) of the National Institutes of Health. The initial Limitx™ formulation utilizes hydromorphone as its sole active ingredient. If such development proves successful, it is expected that the technology could incorporate other opioids as well. Phase I of the research grant is to create an optimized formulation ready for human testing. Phase II will encompass human testing to characterize the abuse deterrent features of the formulation. The need for abuse deterrent formulations which address excess oral consumption was stressed in the January 2013 FDA draft guidance for abuse deterrent opioids. Research on the Company’s hydromorphone tablet utilizing Limitx™ technology is supported by the National Institute On Drug Abuse of the National Institutes of Health under Award Number R44DA037921. The results and content of any such research is solely the responsibility of Acura and does not necessarily represent the official views of the National Institutes of Health. Copyright © 1998-2014 Acura Pharmaceuticals. All rights reserved. Terms of Use and Privacy Policy Risk FactorsContact Us

Home Technologies Market Opportunity Product Portfolio Clinical Investors acura Contact Us Market Opportunity Partnerships Advocacy Groups Patents Business Development Advocacy Below are links to some of the many organizations involved in the efforts to combat the abuse and misuse of prescription and non-prescription drugs. Center for Lawful Access and Abuse Deterrence - http://www.claad.org/ American Pain Society – http://www.ampainsoc.org/ American Society of Addiction Medicine – http://www.asam.org/ American Academy of Pain Management – http://www.aapainmanage.org/ Florida Alcohol and Drug Abuse Association – http://www.fadaa.org/ The Meth Project – http://www.methproject.org/ Narcotics Overdose Prevention & Education (NOPE) Task Force – http://www.nopetaskforce.org/ Operation UNITE – http://operationunite.org/ The Partnership at Drugfree.org – http://www.drugfree.org/ Copyright © 1998-2014 Acura Pharmaceuticals. All rights reserved. Terms of Use and Privacy Policy Risk FactorsContact Us