close preference sidebar This site uses cookies to store information on your computer. Some of these cookies are essential, while others help us to improve your experience by providing insights into how the site is being used. I ACCEPT Necessary Cookies Necessary cookies enable core functionality such as page navigation and access to secure areas. The website cannot function properly without these cookies, and can only be disabled by changing your browser preferences. Analytics analytics option toggle on/off Analytical cookies help us to improve our website by collecting and reporting information on its usage. Marketing marketing option toggle on/off We use marketing (targeting or advertising) cookies to help us improve the relevancy of advertising campaigns you receive. Preferences preferences option toggle on/off A description for Preferences has not been provided. News Contact 1. Use Left/Right arrow keys to allow users to navigate within the navigation links. 2. Use Down arrow key to expand the submenu and up/down arrow keys to navigate within the submenu. 3. Use Enter/Space key to select the menu/submenu items. 4. Use Esc key to leave the submenu. 5. Use Home to select the first item in the menu and End to select the last item in the menu. 6. Use character keys to select the next item having a name that starts with the typed character. About us Our Pipeline Our Technology Partnering Patients Investors Careers Site Search Slider/Carousel Start Previous Slide showing slide 1 of 4 Precision Engineered Medicines We are developing a new generation of medicines by harnessing the body’s natural mechanism of RNAi to precisely target and silence disease-associated genes. Learn More Next Slide Latest News and Events Press Release | November 11, 2021 Silence Therapeutics to Present at Jefferies London Healthcare Conference More News Event | November 18, 2021 Jefferies London Healthcare Conference WEBCAST (OPENS IN NEW WINDOW) More Events Our Global Vision At Silence, we aim to transform peoples’ lives around the world by silencing diseases through our precision engineered medicines and driving positive change for the communities around us. As pioneers in the design and development of siRNAs (short interfering RNAs), we are advancing a new generation of medicines to potentially address the needs of patients who have limited or inadequate treatment options. Learn more Our mRNAi GOLD™ Platform Our proprietary mRNAi GOLD™ platform harnesses the body’s natural mechanism of RNAi (RNA interference) to create precision medicines designed to silence disease-associated genes. We design our siRNAs with patients in mind – to maximize efficacy, minimize off-target effects and have long duration of action. Through this approach, we are advancing a robust pipeline of wholly owned programs and partnership programs for diseases with high unmet need. Learn More Natural Harnesses natural mechanisms present in every cell in the human body Durable Long-lasting gene silencing possible following a single injection Precise siRNA designed to bind only to the target gene +6 Pipeline Programs 2 In Clinical Trials +3 Wholly Owned +5 Strategic Collaborations Our Commitment to Patients We see the patient in every action. Their needs drive our discoveries and relentless commitment to deliver life-changing therapies as efficiently as possible. We know that patients are waiting and that responsibility inspires us to do our best every day. Learn More John-Paul: Living with High Lp(a) Join a Great Place to Work® We’re a vibrant, growing, global company with a start-up mindset. One that begins with doing what we love and ends with fulfilling our vision. We’re seeking smart, fun and passionate people to join our expanding team. Learn More Stay Connected QUICK LINKS About Us Our Pipeline Our Technology Patients Investors CONTACT Corporate Headquarters United Kingdom 72 Hammersmith Rd. London, W14 8TH +44 (0)20 3457 6900 United States 221 River Street, 9th Floor, Hoboken, NJ 07030 Germany Robert-Rossle-Str. 10 D-13125 Berlin Germany +49 30 9489 2800 EMAIL ALERTS Email Address SIGN UP © Silence Therapeutics 2021. All Rights Reserved. Terms of Use Privacy and Cookie Notice Powered By Q4 Inc. 5.56.0.1 (opens in new window)