ABOUT US IVD PRODUCTS RUO PRODUCTS VITAMIN D JOBS Home > IVD Products > ImmunoAssays > Auto-Immunity < you are here ANTIBODIES Bone Metabolism Cancer Markers Cardiovascular & Salt Balance Diabetes & Metabolism Fertility Growth Factors Thyroid Function IMMUNOASSAYS Auto-Immunity 2-Glycoprotein Acetylcholine Receptor ANA 10 ANA 12 ANA 12 Screen ANA 25 Screen ANA 8 ANCA APS ASCA Cardiolipin Connectivitis Cytoplasm dsDNA dsDNA-Ab ENA Nucleosome ENA6 Gastritis GBM Gliadin Intrinsic Factor Liver 10 Liver 4 Liver 5 Liver 7 Lupus Milk Intolerance Mitochondria Mitochondria 4 Nucleosome Nucleosome/Histones Polymyositis/Scleroderma8 β2-Glycoprotein Biogenic Amines Bone Metabolism Cancer Markers Cardiovascular & Salt Balance Diabetes & Metabolism Drug of Abuse Fertility Gastrointestinal Metabolism Growth Factors Immunology Markers Infectious Diseases Others Thyroid Function Urinary Reagents INSTRUMENTS Fully Automated System Open Elisa System Other Instruments CONTACT A DISTRIBUTOR AUTO-IMMUNITY 2-Glycoprotein Acetylcholine Receptor ANA 10 ANA 12 ANA 12 Screen ANA 25 Screen ANA 8 ANCA APS ASCA Cardiolipin Connectivitis Cytoplasm dsDNA dsDNA-Ab ENA Nucleosome ENA6 Gastritis GBM Gliadin Intrinsic Factor Liver 10 Liver 4 Liver 5 Liver 7 Lupus Milk Intolerance Mitochondria Mitochondria 4 Nucleosome Nucleosome/Histones Polymyositis/Scleroderma8 β2-Glycoprotein Autoimmunity is an immune responses of an human organism against its own cells and tissues. This aberrant immune response results in many different disease. These diseases are called autoimmune disease. Examples include Celiac disease, diabetes mellitus type 1, Sarcoidosis, systemic lupus erythematosus (SLE), Sjögren's syndrome, Churg-Strauss Syndrome, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's Disease, rheumatoid arthritis (RA), Polymyositis (PM), and Dermatomyositis (DM). Diagnosis of autoimmune disorders largely rests on accurate history and physical examination of the patient . In several systemic disorders, serological assays which can detect specific autoantibodies are employed: Autoantibodies are used to diagnose many autoimmune diseases and their levels are measured to determine the progress of the disease. The actual growth in testing volumes – as appearance of autoimmune disorders is increasing steadily - will prompt clinical laboratories to employ advanced autoimmune disease diagnostic tests. Several autoimmune disease diagnostic tests however are designed for manual operation and the shortage of skilled technicians limits their use. This creates immense demand for automated diagnostic platforms that facilitate rapid and efficient testing. The constant increase in new diagnostics parameters for autoimmune diseases, the evolution of clinical laboratory demands have led to the development of a complete new range of Auto-Immunity diagnostics kits. DIAsource brings to market a totally new approach of auto-immune testing based on the latest state-of-the-art membrane technology (DOT). This DOT-technology combines simplicity and extraordinary clinical reliability with the possible identification of several autoantibodies in one single test. Together with a dedicated automated instrument, DIAsource Neptune, the diagnosis of auto-immune can be simplified and fully automated. Characteristics of DIASPOT TECHNOLOGY Immunodot technique (based on ELISA technology) Support of reaction: nitrocellulose strip Number of patients tested per kit: 24 Number of auto-antibodies detected: up to 12 Ready to use & color coded reagents and controls Results: Qualitative or semi-quantitative (Neptune Quantification Software) DIASPOT NEPTUNE TECHNOLOGY The DIASpot Neptune kits correspond to the current DIASpot kits, adapted for automation: the strips are mounted on a special plastic support and the reagents are provided in ready-to-use individual cartridges, to fit the NEPTUNE automated instrument. DIASPOT MULTIQUANT TECHNOLOGY First Microarrays in auto-immune diagnostics Up to 25 auto-antibodies detected and quantified per strip Fully automated in 45 min with Neptune Instrument Results in triplicate: Calculation for each results of mean value and standard deviation Many built-in controls: Reactive control or Positive control: validity of the test Conjugate control: control of the conjugate used Substrate kinetic: validity of the substrate 6 point calibration curve: quantitative interpretation Quantitative results and validation of the test with the Neptune Quantification Software Characteristics DIASPOT assays Number of auto-antibodies per strip Up to 12 Up to 12 Up to 25 Testing Manual or open systems NEPTUNE instrument NEPTUNE instrument Test duration 90 min 45 min 45 min Neptune Quantification Software Accessory Accessory Compulsory Neptune Scanner Accessory Accessory Compulsory Results Qualitative or semi-quantitative Qualitative or semi-quantitative Quantitative Built-in-controls 2 2 3 and Calibration curve CONTACT A DISTRIBUTOR Get in touch with a distributor in your country for any technical or commercial question. 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