About Us Life Science Performance Products Contract Manufacturing Products Regulatory News Contact EN CONTRACT MANUFACTURING CONTRACT MANUFACTURING It’s a key activity at MENADIONA. We produce Intermediates of very different features for third parties, under exclusivity and NDA, with long term partnership. BUSINESS DEVELOPMENT, R&D PILOT PLANT, PRODUCTION, KEY TECHNOLOGIES BUSINESS DEVELOPMENT MENADIONA offers contract development and full contract manufacturing services for APIs, advanced intermediates, starting materials and industrial products. MENADIONA delivers cost-efficient synthesis, process development and life-cycle management solutions to customers within the pharmaceutical value chain. Collaborating with MENADIONA is an experience beyond the traditional “Customer – CMO” relationship. In us, you will find a committed company and clearly focused in building long term relationships. With its roots in a non-Pharma business, MENADIONA offers a large experience and the capability to work with hazardous raw materials and controlled substances, which is an important differential characteristic from other CMOs. We are committed, encouraged and equipped so that we can continue developing our strengths and delivering you the benefits of a trusted CMO today and tomorrow. R&D / PILOT PLANT Our R&D laboratory team works for 24h 5 days per week, not only developing new processes but also working continously in process optimization. MENADIONA’s R&D team is organized in several working groups having minimum one PhD. Organic Chemist, plus an Organic Chemist and a Technician. The Pilot Plant, using the same services as the industrial plant like steam and vacuum, is very flexible and allows many combinations of reactors, centrifuges and dryers to be used, in order to perform any type of reaction that, later on will be conducted at industrial scale. MENADIONA’s aim when developing new processes is to face and fix “scaling-problems” at pilot plant stage which disposes of 7 reactors with capacities from 20L to 1.500L made from 3 different materials (Hastelloy, Stainless Steel and Glass lined), 2 centrifuges with capacities of 60L and 400L, and dryers. OUR PACKAGE PRODUCTION MENADIONA facilities are multipurpose and flexible and allow a rapid response to changing customer requirements. After numerous validation runs have been completed, large commercial scale batches are produced at MENADIONA’s manufacturing plant. KEY TECHNOLOGIES MAIN CHEMISTRY & PROCESS: Experts in AZIRIDINE and derivatives. Handling hazardous materials: PCl3, PBr3, Br2, POCl3, Cl2, Me2SO4, NH2NH2 Electrochemical cells Reaction temperatures from -80ºC to 250ºC Vacuum < 1mbar Fractionated Distillations up to 15 theoretical plates MAIN REACTIONS: Amidation Bromination Chlorination Cyclization Grignard Hydrogenation Methylation Nitration Diazotization Friedel Craft Oxidation Reduction EQUIPMENT & CAPACITIES Reactors 60L. to 13.000L. Stainless Steel, Glass Lined, Hastelloy Centrifuges Stainless Steel, PTFE Coated, Hastelloy Dryers Vacuum Dryers, Fluid Bed, Static Trays M3 Reaction capacity Others Milling Capacity Sieving Machines Dispersion Technology Filling Capabilities Hydrogenation Thermal Fluid Waste Water Treatment Plant Your trusted European manufacturer in specialty chemicals ABOUT US Who we are History & Figures Manufacturing Sites Corporate Social Responsibility (CSR) PRODUCTS Life Science Performance Products Contract Manufacturing GET SOCIAL Address: Pol. Ind. Mas Puigvert, s/n - 08389 Palafolls - Barcelona - Spain Copyright © 2018 Menadiona / +34 93 764 07 11 / menadiona@menadiona.com Quality policy | Privacy policy