Open Mobile Menu Press Releases INVESTORS NEWS & EVENTS Overview Press Releases IR Calendar Email Alerts Codexis Reports Third Quarter 2021 Financial Results Download as PDF NOVEMBER 04, 2021 4:05PM EDT Related Documents AUDIO Earnings Webcast 10-Q Filing PDF HTML XBRL ZIP XLS HTML Q3 2021 Results Presentation PDF Record Quarterly Total Revenue, Product Revenue and Product Gross Margin Reiterating Total Revenue Guidance of $98-103M; Raising Product Revenue Guidance to $63-66M REDWOOD CITY Calif., Nov. 04, 2021 (GLOBE NEWSWIRE) -- Codexis, Inc. (Nasdaq:CDXS), a leading enzyme engineering company enabling the promise of synthetic biology, today announced financial results for the third quarter ended September 30, 2021 and provided a business update. “Codexis delivered another quarter of exceptional strategic and operational performance,” said John Nicols, Codexis President and CEO. “Our Sustainable Manufacturing business demonstrated remarkable growth, as we significantly executed against the large enzyme orders we received from Pfizer to support its COVID-19 antiviral therapeutic candidate. Our capacity to fulfill this order in such a rapid timeframe highlights the strength of our supply chain and the value of our deep library of performance enzymes. Also in the third quarter, with Merck and Almelo, we established our first two multi-year agreements to extend our longstanding sitagliptin product business into its generic chapter. We also delivered strong results in the faster-to-market food sector, including enzyme sales for Tate & Lyle sweeteners and a milestone from Kalsec for their newest natural hop ingredient. “In the Life Science Tools market, we are extremely pleased to have recorded our first sales of Codex® HiFi DNA Polymerase in the third quarter. We remain on track with our groundbreaking collaboration with Molecular Assemblies (MAI) for the commercialization of enzymatic DNA synthesis. Underscoring our enthusiasm for this disruptive approach, we recently made an additional investment in MAI alongside Casdin Capital enabled by our SynBio Innovation Accelerator. Our high-value Biotherapeutics pipeline is also advancing steadily, including the recent initiation of our Phase 1 clinical trial of CDX-7108, our program co-owned with Nestlé Health Science, for the treatment of exocrine pancreatic insufficiency. Codexis remains on the cutting edge of synthetic biology’s evolution, leveraging the near-boundless potential of our enzymes to improve the health of people and the planet.” Key Performance Indicators and Recent Business Highlights Product revenues increased 242% to $28.7 million in Q3’21, primarily driven by the sale of a proprietary Codexis enzyme to manufacture Pfizer’s clinical-stage COVID antiviral therapeutic candidate. Product gross margin increased to a record 76% in Q3’21, driven by a shift in the sales mix to higher margin products. In the third quarter, Codexis had 19 customers who contributed over $100,000 in revenue, seven of which contributed over $1 million in revenue. In the Sustainable Manufacturing market of the Performance Enzymes segment, in August Codexis received two new purchase orders for approximately $15.0 million for a proprietary Codexis enzyme to manufacture Pfizer’s clinical-stage COVID antiviral therapeutic candidate, PF-07321332. This followed a large order of $13.9 million for this enzyme that Codexis received in June. In aggregate, the orders the Company received in June and August total approximately $29.0 million. Codexis amended and extended its agreement with Merck to license and supply a proprietary enzyme used in the manufacturing process for sitagliptin, the active pharmaceutical ingredient (API) in Merck’s JANUVIA® and JANUMET®. The Company also recently announced a tri-party collaboration agreement with Almelo Private, Ltd., an Indian producer of APIs, and RC2 Pharma Connect, LLC, a U.S.-based leading pharmaceutical manufacturing representative, to license and manufacture Codexis’ proprietary enzyme for sitagliptin to be used in the manufacture of sitagliptin for the future generic market. Codexis announced an expanded, exclusive commercial supply agreement with Kalsec for a novel enzyme to sustainably produce their natural, clean-label hop ingredient. The Company also earned a milestone from Kalsec in the quarter for Generally Recognized as Safe (GRAS) self-affirmation of this enzyme. In the Life Science Tools market within the Performance Enzymes segment Codexis recorded its first commercial sale of Codex® HiFi DNA polymerase in the third quarter. The Company expects to launch Codex® Reverse Transcriptase into sequencing applications in December. Enabled by the SynBio Innovation Accelerator, Codexis made an additional $7.0 million investment in Molecular Assemblies (MAI), alongside a $3.0 million investment by Casdin Capital in MAI. In the Novel Biotherapeutics segment, Codexis’ pipeline includes 13 programs. The Company recently announced the initiation of a Phase 1 clinical trial of CDX-7108, which is co-owned with Nestlé Health Science, for the treatment of exocrine pancreatic insufficiency. Third Quarter 2021 Financial Highlights Total revenues for the third quarter 2021 were $36.8 million, an increase of 100% from $18.4 million in the third quarter 2020. On a segment basis, $32.6 million in revenue was from the Performance Enzymes segment and $4.2 million was from the Novel Biotherapeutics segment. Product revenues for the third quarter 2021 were $28.7 million compared to $8.4 million in the third quarter 2020; the increase was the result of higher sales of enzymes used to manufacture branded pharmaceutical products, primarily Pfizer. R&D revenues were $8.0 million compared to $10.0 million last year. The decrease was driven by lower R&D revenue from several large pharmaceutical companies and a shift towards more self-funded R&D programs. Product gross margin for the third quarter 2021 was 76% compared to 57% in the third quarter 2020. The increase was driven by increased sales of higher margin products. R&D expenses for the third quarter 2021 were $15.2 million compared to $12.0 million in the third quarter 2020. The increase was driven by higher compensation expenses driven primarily by higher headcount, cost of lab supplies and depreciation, partially offset by lower preclinical development and regulatory expenses. Selling, General & Administrative expenses for the third quarter 2021 were $13.4 million, compared to $8.8 million in the third quarter 2020. The increase was the result of higher expenses for compensation, primarily driven by higher headcount, and higher legal fees. Net income for the third quarter 2021 was $2.2 million, or $0.03 per share, compared to a net loss of $6.1 million, or $0.10 per share, for the third quarter 2020. As of September 30, 2021, the Company had $119.2 million in cash and cash equivalents. Guidance Codexis is updating its financial guidance issued on August 5, 2021, as follows: FY 2021 total revenues continue to be expected in the range of $98 - $103 million FY 2021 product revenues are now expected to be in the range of $63 - $66 million compared to $59 - $63 million previously FY 2021 gross margin on product revenue is expected to be in the range of 68% to 71% compared to 65% to 68% previously Conference Call and Webcast Codexis will hold a conference call and webcast today beginning at 4:30 p.m. ET. A live webcast and slide presentation to accompany the conference call will be available on the Investor section of Company website. The conference call dial-in numbers are (866) 682-6100 for domestic callers and (862) 298-0702 for international callers, and the passcode is 13724176. A recording of the call will be available for 48 hours beginning approximately two hours after the completion of the call by dialing 877-660-6853 for domestic callers or 201-612-7415 for international callers. Please use the passcode 13721066 to access the recording. A webcast replay will be available on the Investors section of www.codexis.com for 30 days, beginning approximately two hours after the completion of the call. About Codexis Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver® platform to discover and develop novel, high performance enzymes and novel biotherapeutics. Codexis enzymes have applications in the sustainable manufacturing of pharmaceuticals, food, and industrial products; in the creation of the next generation of life science tools; and as gene therapy and biologic therapeutics. The Company’s unique performance enzymes drive improvements such as: reduced energy usage, waste generation and capital requirements; higher yields; higher fidelity diagnostics; and more efficacious therapeutics. Codexis enzymes enable the promise of synthetic biology to improve the health of people and the planet. For more information, visit www.codexis.com. Forward-Looking Statements To the extent that statements contained in this press release are not descriptions of historical facts regarding Codexis, they are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including, among others: Codexis’ guidance on 2021 total revenues, product revenues and gross margin; prospects for product revenue and product margin growth in Codexis’ Sustainable Manufacturing business; prospects for Codexis’ self-funded programs and Life Science Tools business and growth in its project pipeline and the anticipated initiation of a first clinical trial of CDX-7108. You should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties and other factors that are, in some cases, beyond Codexis’ control and that could materially affect actual results. Factors that could materially affect actual results include, among others: Codexis’ dependence on its licensees and collaborators; Codexis’ dependence on a limited number of products and customers and potential adverse effects to Codexis’ business if its customers’ products are not received well in the markets. Additional information about factors that could materially affect actual results can be found in Codexis’ Annual Report on Form 10-K filed with the Securities and Exchange Commission (“SEC”) on March 1, 2021, and in Codexis’ Quarterly Report on Form 10-Q filed with the SEC on August 6, 2021, including under the caption “Risk Factors,” and in Codexis’ other periodic reports filed with the SEC. Codexis expressly disclaims any intent or obligation to update these forward-looking statements, except as required by law. Investor Relations Contact: Argot Partners Stephanie Marks/Carrie McKim (212) 600-1902 Codexis@argotpartners.com Financial Tables to Follow Codexis, Inc. Condensed Consolidated Statements of Operations (Unaudited) (In Thousands, Except Per Share Amounts) Three Months Ended September 30, Nine Months Ended September 30, 2021 2020 2021 2020 Revenues: Product revenue $ 28,731 $ 8,401 $ 53,674 $ 18,005 Research and development revenue 8,038 9,984 26,579 30,018 Total revenues 36,769 18,385 80,253 48,023 Costs and operating expenses: Cost of product revenue 6,867 3,642 15,403 7,882 Research and development 15,165 12,010 39,562 33,830 Selling, general and administrative 13,407 8,797 37,600 26,307 Total costs and operating expenses 35,439 24,449 92,565 68,019 Income (loss) from operations 1,330 (6,064 ) (12,312 ) (19,996 ) Interest income 41 39 424 362 Other income (expense), net 983 (50 ) 920 (125 ) Income (loss) before income taxes 2,354 (6,075 ) (10,968 ) (19,759 ) Provision for income taxes 110 19 121 331 Net income (loss) $ 2,244 $ (6,094 ) $ (11,089 ) $ (20,090 ) Net income (loss) per share, basic $ 0.03 $ (0.10 ) $ (0.17 ) $ (0.34 ) Net income (loss) per share, diluted $ 0.03 $ (0.10 ) $ (0.17 ) $ (0.34 ) Weighted average common stock shares used in computing net income (loss) per share, basic 64,628 59,061 64,452 58,984 Weighted average common stock shares used in computing net income (loss) per share, diluted 67,741 59,061 64,452 58,984 Codexis, Inc. Condensed Consolidated Balance Sheets (Unaudited) (In Thousands) September 30, 2021 December 31, 2020 Assets Current assets: Cash and cash equivalents $ 119,189 $ 149,117 Restricted cash, current 581 638 Investment in non-marketable debt security — 1,000 Financial assets: Accounts receivable 25,084 13,894 Contract assets 12,701 4,526 Unbilled receivables 10,760 10,942 Total financial assets 48,545 29,362 Less: allowances (74 ) (74 ) Total financial assets, net 48,471 29,288 Inventories 1,084 964 Prepaid expenses and other current assets 4,787 3,416 Total current assets 174,112 184,423 Restricted cash 1,519 1,062 Investment in non-marketable equity securities 12,763 1,450 Right-of-use assets - Operating leases, net 19,478 21,382 Right-of-use assets - Finance leases, net 43 119 Property and equipment, net 16,124 9,675 Goodwill 3,241 3,241 Other non-current assets 271 294 Total assets $ 227,551 $ 221,646 Liabilities and Stockholders' Equity Current liabilities: Accounts payable $ 3,281 $ 2,970 Accrued compensation 9,041 7,288 Other accrued liabilities 15,927 10,272 Current portion of lease obligations - Operating leases 2,782 2,627 Deferred revenue 2,449 1,824 Total current liabilities 33,480 24,981 Deferred revenue, net of current portion 3,747 2,967 Long-term lease obligations - Operating leases 20,218 22,324 Other long-term liabilities 1,051 1,271 Total liabilities 58,496 51,543 Stockholders' equity: Common stock 6 6 Additional paid-in capital 546,557 536,516 Accumulated deficit (377,508 ) (366,419 ) Total stockholders' equity 169,055 170,103 Total liabilities and stockholders' equity $ 227,551 $ 221,646 Codexis, Inc. Segmented Information (Unaudited) (In Thousands) Three months ended September 30, 2021 Three months ended September 30, 2020 Performance Enzymes Novel Biotherapeutics Total Performance Enzymes Novel Biotherapeutics Total Revenues: Product revenue $ 28,731 $ — $ 28,731 $ 8,401 $ — $ 8,401 Research and development revenue 3,853 4,185 8,038 4,604 5,380 9,984 Total revenues 32,584 4,185 36,769 13,005 5,380 18,385 Costs and operating expenses: Cost of product revenue 6,867 — 6,867 3,642 — 3,642 Research and development (1) 5,670 8,850 14,520 5,184 6,433 11,617 Selling, general and administrative(1) 3,306 831 4,137 2,675 515 3,190 Total segment costs and operating expenses 15,843 9,681 25,524 11,501 6,948 18,449 Income (loss) from operations $ 16,741 $ (5,496 ) 11,245 $ 1,504 $ (1,568 ) (64 ) Corporate costs (2) (8,097 ) (5,483 ) Unallocated depreciation and amortization (794 ) (528 ) Income (loss) before income taxes $ 2,354 $ (6,075 ) (1) Research and development expenses and selling, general and administrative expenses exclude depreciation and amortization of finance leases. (2) Corporate costs include unallocated selling, general and administrative expense, interest income, and other income (expense), net. Nine months ended September 30, 2021 Nine months ended September 30, 2020 Performance Enzymes Novel Biotherapeutics Total Performance Enzymes Novel Biotherapeutics Total Revenues: Product revenue $ 53,674 $ — $ 53,674 $ 18,005 $ — $ 18,005 Research and development revenue 14,723 11,856 26,579 13,380 16,638 30,018 Total revenues 68,397 11,856 80,253 31,385 16,638 48,023 Costs and operating expenses: Cost of product revenue 15,403 — 15,403 7,882 — 7,882 Research and development (1) 17,172 20,649 37,821 15,877 16,848 32,725 Selling, general and administrative(1) 9,294 2,052 11,346 7,395 1,728 9,123 Total segment costs and operating expenses 41,869 22,701 64,570 31,154 18,576 49,730 Income (loss) from operations $ 26,528 $ (10,845 ) 15,683 $ 231 $ (1,938 ) (1,707 ) Corporate costs (2) (24,431 ) (16,526 ) Unallocated depreciation and amortization (2,220 ) (1,526 ) Loss before income taxes $ (10,968 ) $ (19,759 ) (1) Research and development expenses and selling, general and administrative expenses exclude depreciation and amortization of finance leases. (2) Corporate costs include unallocated selling, general and administrative expense, interest income, and other income (expense), net. Source: Codexis, Inc. Released November 4, 2021 Email Alerts Contacts RSS News Feed twitter linkedin CONTACTINVESTORSCAREERSTRADEMARKSPATENTSTERMS OF USEPRIVACY © 2021 Codexis. All rights reserved.