Home About Services Drug Discovery News Careers Contact Pharmacokinetics/Exogenous Molecules Pharmacokinetics (PK) is an important aspect of animal studies and Psychogenics now offers a wide range of PK options which provide details on route, dosing concentration, timing etc to insure a successful subsequent study. Various routes of administration (PO, IV, SC, IM) coupled with terminal (plasma and tissue measures) or serial (plasma) collections can be tailored to provide the desired PK data. IV vs PO dosing comparing compound A IV vs PO dosing comparisons provide an indication of how the fate of the drug is impacted by the dosing route. PO dosing is expected to delay delivery of the drug and this is clearly observed in the IV vs PO dosing plot below. IV vs PO dosing (1 mg/kg) in Sprague Dawley rats with LCMS bioanalysis of compound A-2 in plasma following serial collection of blood over a 7 hour time course. PO dosing comparing analogs of compound A Minor structural changes in compound A were also examined to determine their impact on the fate of the drug after PO dosing. Minor alterations in compound A did not result in a significant alteration of the PK data. PO dosing (1 mg/kg) in Sprague Dawley rats with LCMS bioanalysis of compound A-1 and A-2 in plasma following serial collection of blood over a 7 hour time course. Want to get in touch? Connect with the PsychoGenics research team. Connect With Us CONTACT PsychoGenics Inc. 215 College Road, Paramus, NJ 07652 Email: info@psychogenics.com Phone: (914) 406-8019 Fax: (914) 406-8090 Privacy Policy Terms of Use Financial Conflict of Interest Policy Copyright ©2021 PsychoGenics Inc. All rights reserved. We are using cookies to give you the best experience on our website. You can find out more about which cookies we are using or switch them off in settings. Accept