EYE CONCERNS PRODUCTS OUR COMPANY NEWS ORDER ONLINE Consumer Reference Please read the Instructions for Use (IFU) for important product use and safety information associated with Bausch + Lomb contact lenses and lens care solutions. # PRODUCT CLAIM REFERENCE 1 Bausch + Lomb ULTRA ONE DAY The Most Complete Silicone Hydrogel Daily Disposable Contact Lens Only Bausch + Lomb ULTRA® ONE DAY contact lenses offer a complete moisture + comfort system with Advanced MoistureSeal® and ComfortFeel Technologies plus a complete design of high Dk/t, low modulus, UV blocking and High Definition Optics. Bausch + Lomb ULTRA® ONE DAY contact lenses deliver health through its complete system working together to support a healthy ocular environment, the inclusion of eye health ingredients which are retained over 16 hours and the high allowance of oxygen permeability (Dk/t=134) (Applicable references 2-5) 2 Bausch + Lomb ULTRA ONE DAY Schafer J., Steffen R., Reindel W. A clinical assessment of dehydration resistance for a novel silicone hydrogel lens and six silicone hydrogel daily disposable lenses. Poster presented at AAO; October 2020. 3 Bausch + Lomb ULTRA ONE DAY Rah M. Ocular surface homeostasis and contact lens design. February 2021. 4 Bausch + Lomb ULTRA ONE DAY Data on File. Product Performance Evaluation of a Novel Silicone Hydrogel Contact Lens: kalifilcon A Daily Disposable Contact Lenses - Summary of kalifilcon A Patient Comfort and Vision Outcomes. Bausch & Lomb Incorporated, Rochester, NY, 2021. 5 Bausch + Lomb ULTRA ONE DAY Competitive grid packaging solutions with sources. 6 Bausch + Lomb ULTRA ONE DAY Wearers overwhelmingly agreed that Bausch + Lomb ULTRA® ONE DAY contact lenses made their eyes feel Comfortable All Day Data on File. Product Performance Evaluation of a Novel Silicone Hydrogel Contact Lens: kalifilcon A Daily Disposable Contact Lenses - Summary of kalifilcon A Patient Comfort and Vision Outcomes for Patients Who Reported Dryness with Their Habitual Lenses. Bausch & Lomb Incorporated, Rochester, NY, 2021 7 Bausch + Lomb ULTRA ONE DAY UV Blocking UV-absorbing contact lenses are NOT substitutes for protective UV-absorbing eyewear such as UV-absorbing goggles or sunglasses because they DO NOT completely cover the eye and surrounding area. You should continue to use UV-absorbing eyewear as directed. U.S. Food & Drug Administration 510(k) Summary K200528; Bausch + Lomb (kalifilcon A) Soft (hydrophilic) Contact Lens. May 2020. 8 Bausch + Lomb ULTRA ONE DAY Bausch + Lomb ULTRA® ONE DAY contact lenses provide the Highest Moisture † vs. Dailies Total1® and Acuvue® Oasys 1-Day contact lenses Johnson & Johnson Acuvue® Oasys 1-Day with Hydraluxe™ Contact Lens Package Insert. 9 Bausch + Lomb ULTRA ONE DAY Bausch + Lomb ULTRA® ONE DAY contact lenses provide the Highest Moisture † vs. Dailies Total1® and Acuvue® Oasys 1-Day contact lenses Alcon DAILIES TOTAL1®Contact Lens Package Insert. 10 Bausch + Lomb ULTRA ONE DAY Delivers outstanding comfort for a full 16 hours of wear Bausch + Lomb ULTRA® ONE DAY contact lenses go beyond today’s contact lens constraints Data on file. Product Performance Evaluation of a Novel Silicone Hydrogel Contact Lens: kalifilcon A Daily Disposable Contact Lenses - Summary of kalifilcon A Patient Comfort and Vision Outcomes for Patients Who Wore Lenses for 16 or More Hours Per Day. Bausch & Lomb Incorporated, Rochester, NY, 2021. 11 Bausch + Lomb ULTRA ONE DAY Supports a stable and healthy ocular surface environment VanDerMeid K, et al. Evaluation of erythritol and glycerin osmoprotection characteristics on an ocular surface cell line under hyperosmotic conditions. Poster presentation at the American Academy of Optometry Annual Meeting 2020. 12 Bausch + Lomb ULTRA ONE DAY Bausch + Lomb ULTRA® ONE DAY contact lenses go beyond today’s contact lens constraints Results of a consumer symptoms survey of 318 silicone hydrogel daily disposable contact lens wearers. Kadence International, April 2019. # PRODUCT CLAIM REFERENCE 1.1 Bausch + Lomb ULTRA Multifocal for Astigmatism With 3-Zone Progressive Design™ and OpticAlign™ Design for stable, seamless vision near, far and in-between1,2 ULTRA® Comfort Experience™ for Presbyopia Data Analysis Phase 1 + 2. 2017. 1.2 Bausch + Lomb ULTRA Multifocal for Astigmatism The OpticAlign™ Design provides ballasting in the lower hemisphere to minimise lens rotation— ≤5° rotation for 95% of patients. Bausch + Lomb ULTRA® Multifocal for Astigmatism stabilisation study. 1.3 Bausch + Lomb ULTRA Multifocal for Astigmatism SIMPLE OFFERING Easy to fit, in stock and ready to ship EASY TO FIT FIRST TIME 4 of 5 patients successfully fit in one visit* Bausch + Lomb, 2013. Perceptions of Bausch + Lomb PureVision® 2 for Presbyopia (#815). Rochester. * When the ECP followed the fitting guide Bausch + Lomb., 2016. A study to evaluate the product performance of two designs of soft toric lenses (#ROC2-16-016). Rochester 1.5 Bausch + Lomb ULTRA Multifocal for Astigmatism Almost 50% of the European population (~245M) falls within the presbyopia candidate age range and this population is growing5,6,7 5. Demographic outlook for the European Union 2020, EPRS European Parliamentary Research Service, March 2020. 6. Population structure indicators, Eurostat 3 July 2020. 7. Population change, Eurostat 10 July 2020. 1.8 Bausch + Lomb ULTRA Multifocal for Astigmatism Between the age of 45 and 54 contact lens wear drop-out coincides with the onset of presbyopia Understanding the needs of pre-presbyopes and emerging presbyopes | Points de Vue | International Review of Ophthalmic Optics, May 2014. 1.9 Bausch + Lomb ULTRA Multifocal for Astigmatism 83% will have some stage of presbyopia by the age of 45 Holden BA, Fricke TR, Ho SM et al., 2008. Global vision impairment due to uncorrected presbyopia. Arch Ophthalmol 126 pp 1731-1739 1.10 Bausch + Lomb ULTRA Multifocal for Astigmatism But as vision correction needs increase with age, contact lens wear decreases Vision Needs Monitor 2013. 1.11 Bausch + Lomb ULTRA Multifocal for Astigmatism 47% of patients have astigmatism in at least one eye* Young, G., Sulley, A., Hunt, C., 2011. Prevalence of astigmatism in relation to soft contact lens fitting. Eye & Contact Lens, 37 (1). * The prevelance of patients showing astigmatism of 0.75 and 1.00D or greater in at least one eye was 47.4% 1.12 Bausch + Lomb ULTRA Multifocal for Astigmatism All presbyopes (astigmatic or not) have the same vision correction needs: Sharp, clear vision at near Sharp, clear vision at mid-range Ease of transition between near and far The 2020 Study of US. Multifocal contact lens market. 1.13 Bausch + Lomb ULTRA Multifocal for Astigmatism Near and intermediate vision are cited as the biggest concerns about becoming presbyopic Opinion Health Questionnaire, December 2018. 1.14 Bausch + Lomb ULTRA Multifocal for Astigmatism Over half of astigmatic presbyopes contact lens wearers say as vision correction changed, contact lens options haven’t kept up with their needs Astigmatic presbyopes have to make many COMPROMISES WITH THEIR VISION CORRECTION Kadence, 2019. Presbyopic Astigmats Symptom Tracker Quantitative Report. 1.15 Bausch + Lomb ULTRA Multifocal for Astigmatism 58% Dislike Wearing Glasses 58% Appearance/Look Better 50% Better for Active Lifestyle Multi-sponsor Surveys Inc, 2019. The 2018 target report on contact lens marketing opportunities among 40+ presbyopes with astigmatism 1.16 Bausch + Lomb ULTRA Multifocal for Astigmatism 75% of astigmatic presbyopes agree multifocal toric contact lenses offer benefits over current correction16 DeNovo Research Solutions,. 2018. Bausch + Lomb ULTRA® Multifocal for Astigmatism contact lens price sensitivity with consumers (n=502). 1.17 Bausch + Lomb ULTRA Multifocal for Astigmatism Ultra comfort and consistently clear vision. For comfortable vision throughout the day. 9 out of 10 patients agree that Bausch + Lomb ULTRA® contact lenses are as comfortable at the end of the day as they are at the beginning Rah, M., Reindel, W., et al., 2015. Interest and Acceptance of a new contact lens technology in today’s practice. Poster Presentation AOA Annual Meeting, Seattle. 1.18 Bausch + Lomb ULTRA Multifocal for Astigmatism Maintains 95% of moisture for a full 16 hours Bausch + Lomb ULTRA® MoistureSeal® technology - high water content, moisture retention and exceptional surface wettability and durability18,19,20,21 18. Bausch + Lomb, 2013. 16 Hour bilateral dispensing evaluation of methacrylamide lenses as compared to Air Optix® Aqua, Acuvue® Oasys® and Biofinity® lenses (#ROC2-13-002). 1.19 Bausch + Lomb ULTRA Multifocal for Astigmatism Bausch + Lomb ULTRA® MoistureSeal® technology - high water content, moisture retention and exceptional surface wettability and durability18,19,20,21 Moisture Retention in Lens Core High volume of PVP at the core provides excellent moisture retention19,20 High Wettability at Surface Tightly compact PVP at the surface provides high wettability19,21 19. Hook, D., 2013. Gradient of PVP from Surface to Bulk. Rochester. 1.20 Bausch + Lomb ULTRA Multifocal for Astigmatism Bausch + Lomb ULTRA® MoistureSeal® technology - high water content, moisture retention and exceptional surface wettability and durability18,19,20,21 Moisture Retention in Lens Core High volume of PVP at the core provides excellent moisture retention19,20 20. Steffen, R., Hook, D., et al. New Technology Yields Dehydration Resistance. 1.21 Bausch + Lomb ULTRA Multifocal for Astigmatism Bausch + Lomb ULTRA® MoistureSeal® technology - high water content, moisture retention and exceptional surface wettability and durability18,19,20,21 Tightly compact PVP at the surface provides high wettability19,21 21. Wygladacz, K., Taddei, A., Hook, D. Surface and Bulk Poperties of a Novel Inherently Wettable Silicone Hydrogel Material. 1.23 Bausch + Lomb ULTRA Multifocal for Astigmatism The 3-Zone Progressive Design™ includes three distinct power zones to deliver exceptional vision and seamless transitions across all distances.1,23 Like Bausch + Lomb ULTRA® for Presbyopia, this lens features large areas of consistent focusing power in the near, intermediate, and distance zones. 23. Reindel, W., et al., 2015. Ergonomic Utility of Progressive Multifocal Contact Lenses: A Comparison of Power Profiles Across Near, Intermediate and Distance Zones. AAO Poster Presentation. 1.25 Bausch + Lomb ULTRA Multifocal for Astigmatism Seamless vision at all distances ranked by ECPs as most important for successful multifocal toric lens wear. When considering a successful multifocal toric lens fitting experience, ECPs rank minimal rotation as most significant. SERMO., 2019. Multifocal Toric Contact Lenses survey. 1.26 Bausch + Lomb ULTRA Multifocal for Astigmatism Thin-edge design minimises lid interaction Bausch + Lomb, 2016. Bausch + Lomb ULTRA® for Astigmatism Design Description. 1.27 Bausch + Lomb ULTRA Multifocal for Astigmatism Material that delivers high oxygen transmissibility and low modulus Hook, D., 2017. Bausch + Lomb ULTRA® Properties Comparison Memo (revision b). Rochester 1.29 Bausch + Lomb ULTRA Multifocal for Astigmatism HIGH PATIENT SATISFACTION Almost 90% Clear near vision up close 95% Clear vision at intermediate 93% Clear vision at distance 92% Comfortable throughout the day Bausch + Lomb., 2019., Bausch + Lomb ULTRA® Multifocal for Astigmatism Patient Evaluations Survey. 1.30 Bausch + Lomb ULTRA Multifocal for Astigmatism 87% preferred Bausch + Lomb ULTRA® Multifocal for Astigmatism over their previous contact lenses, readers or spectacles The lens that 9 out of 10 astigmatic presbyopes preferred over their previous contacts, readers or spectacles Bausch + Lomb., 2019., Bausch + Lomb ULTRA® Multifocal for Astigmatism Patient Evaluations Survey. Binomial Confidence Intervals for Claim Support # PRODUCT CLAIM REFERENCE 2.1 Bausch + Lomb ULTRA For reusable contact lens wearers “good vision” and “comfort” are the most important attributes3 3. Opinion Health., 2018. Contact Lens Survey: Sight into Drivers and Barriers of Contact Lens Usage. 2.2 Bausch + Lomb ULTRA MoistureSeal® technology Proprietary, two-phase manufacturing process fuses water loving PVP (polyvinylpyrrolidone) into a silicone hydrogel matrix to drive high water content, moisture retention and exceptional surface wettability and durability for long-lasting comfort and visual performance14 14. Wygladacz, K., Hook, D., Steffen, R., Reindel, W., 2014. “Break the Cycle of Discomfort,” Contact Lens Spectrum/ Special Edition, pp. 23. (REF-CL spectrum). 2.3 Bausch + Lomb ULTRA Precision optics for sharp vision16,23,24 Vision as clear at the end of the day as at the beginning16,23,24 PROVIDES VISION AS CLEAR AT THE END OF THE DAY AS AT THE BEGINNING16 Spherical aberration control For sharp vision and a reduction in halos and glare, even in low light conditions and when driving at night16,25,26 16. Bausch + Lomb, 2013. A study to evaluate the product performance of a new silicone hydrogel contact lens (#817). Rochester. 2.4 Bausch + Lomb ULTRA Superior surface smoothness and durability17,† † Vs Acuvue® Oasys®, Biofinity® and Air Optix® Aqua Consistently smooth and durable lens surface over the 30 day wear cycle17 17. Merchea, M., Wygladacz, K.A., et al., 2014. Comparative Surface Smoothness Durability of a Novel Silicone Hydrogel Material. Association for Research in Vision and Ophthalmology 2014 annual meeting. 2.5 Bausch + Lomb ULTRA Long-lasting moisture retention18,19 18. Hoteling, A., Nichols, W., et al., 2014. PVP content of a silicone hydrogel material with dual phase polymerisation processing. American Optometric Association Annual Meeting; 2014, Philadelphia, PA. 19. Bausch + Lomb, 2013. 16 Hour bilateral dispensing evaluation of methacrylamide lenses as compared to Air Optix® Aqua, Acuvue® Oasys® and Biofinity® lenses (#ROC2-13-002). 2.6 Bausch + Lomb ULTRA Maintains 95% of moisture for a full 16 hours19 MoistureSeal® technology: Delivers moisture retention and a highly wettable surface for long-lasting wear19 19. Bausch + Lomb, 2013. 16 Hour bilateral dispensing evaluation of methacrylamide lenses as compared to Air Optix® Aqua, Acuvue® Oasys® and Biofinity® lenses (#ROC2-13-002). 2.7 Bausch + Lomb ULTRA Comfort and visual performance day in, day out... month after month22,23,24 At 12 months overall comfort rated as 91% and overall vision 95%22 High Patient Satisfaction: 90% Comfortable even after a full month of wear22 95% Provides clear vision even after a full month of wear22 20 Schafer, J., Reindel, W., et al. Use of a novel extended blink test to evaluate polyvinylpyrrolidone(PVP) contact lens containing polymer performance. 2.8 Bausch + Lomb ULTRA Comfort and visual performance day in, day out... month after month22,23,24 At 12 months overall comfort rated as 91% and overall vision 95%22 High Patient Satisfaction: 90% Comfortable even after a full month of wear22 95% Provides clear vision even after a full month of wear22 22. Reindel, W., Mosehauer, G., et al., 2018. Patient comfort, vision and cleanliness over 12-months of Samfilcon A Lens Wear. Poster presented at AAO. 2.9 Bausch + Lomb ULTRA for Astigmatism Delivers all day comfort, stability and consistently clear vision23 High Patient Satisfaction: 91% Provides comfort throughout the day 93% Provides consistently clear vision throughout the day 96% Provides clear vision for physical activities 93% Helps reduce halos and glare 95% Provides clear vision when driving at night 23. Micromass Communications Inc., 2017. Statistical Analysis of Bausch + Lomb ULTRA® for Astigmatism Lenses Challenge Patient Survey. (n=426). 2.10 Bausch + Lomb ULTRA for Presbyopia 3-Zone Progressive Design™: for outstanding vision near, far and in-between24 Ultimate comfort, clear vision with 3-Zone Progressive Design™ for seamless transitions near, far and in-between24,29 3 distinct zones with consistent power24 Smooth transition between 3 zones for easy adaptation between key distances24 24. Micromass, 2017. Bausch + Lomb ULTRA Comfort Experience for Presbyopia Final Results Report 2.11 Bausch + Lomb ULTRA for Astigmatism Spherical Aberration Control: optimised in both axes for sharp vision and a reduction in halos and glare25 Practitioners reported rotation at dispensing of <5˚ for 94% of patients25 Practitioners rated the speed of fitting as excellent or very good for 92% of patients25 Practitioners agreed lenses delivered clear vision for 9 out of 10 patients25 25. Bausch + Lomb., 2016. A study to evaluate the product performance of two designs of soft toric lenses (#ROC2-16-016). Rochester 2.12 Bausch + Lomb ULTRA for Astigmatism OpticAlign™ Design: to promote stability and a successful first fit25,26 26. Hovinga, K.R., 2016. ULTRA® for Astigmatism Design Description (#LDR168022). 2.13 Bausch + Lomb ULTRA for Astigmatism Bausch + Lomb ULTRA® is designed to reduce both the inherent and induced spherical aberration27,28 27. Hovinga, K., 2013. Bench-top wavefront measurement comparison of Samfilcon A ULTRA® SVS Lens to competitor SVS products (#LDR138011). 28. Hovinga, K.R., 2016. Summary of ULTRA® for Astigmatism Spherical Aberration Control. (#LDR168021) (reduce halos and glare). 2.14 Bausch + Lomb ULTRA for Presbyopia 4 out of 5 / 80% patients successfully fit in just one visit*29 96% of patients successfully fitted in two visits*29 *When the ECP followed the fitting guide Patients agree lenses featuring 3-Zone Progressive Design™provide excellent near, intermediate and distance vision for real world tasks29,37 when: using a computer – 96% using a mobile phone -96% reading printed material- 93% driving during the day-93% doing physical activities- 93% at the end of the day- 94% 29. Bausch + Lomb, 2013. Perceptions of Bausch + Lomb PureVision® 2 for Presbyopia (#815). Rochester. 37. Wright, M., et al., 2016. Capturing the presbyopic opportunity. Review of Optometric Business. 2.15 Bausch + Lomb ULTRA for Astigmatism Spherical Aberration Control: for sharp vision and a reduction in halos and glare16,30 30. Hovinga, K.R., Ludington, P.D., et al., 2014. Preventing dehydration blur. Contact Lens Spectrum Special Edition, pp 39-42. 2.16 Bausch + Lomb ULTRA for Astigmatism Ultimate comfort, clear vision with OpticAlign™ Design for rotational stability and speed of fit25,31 31. Hovinga, K.R., 2016. Summary of ULTRA® for Astigmatism Orientation and Axis Markings (#LDR168019). 2.17 Bausch + Lomb ULTRA 90% ECPs are satisfied with the results obtained with the lens32 79% ECPs consider the lenses as the first option for patients who need reusable spherical contact lenses32 82% Patients prescribed lenses after trial32 High Patient Satisfaction: 72% Better than their previous contact lenses32 32. Galileo Business Consulting, 2019. Assessment of patient satisfaction after a fitting with the reusable contact lenses: Bausch + Lomb ULTRA® Spherical. Synthesis Report. 2.18 Bausch + Lomb ULTRA for Presbyopia 85% agree lenses are as comfortable at the end of the day as the beginning41 High Practitioner Satisfaction: 93% overall satisfaction41 100% First choice multifocal reusable contact lens for patients41 Practitioner experience compared to reusable multifocal lens prescribed most often41: Overall comfort at the end of the day – 92% better Quality of near vision- 47% better Quality of intermediate vision- 62% better Quality of distance vision-25% better 41. Galileo Business Consulting, 2019. Assessment of PATIENT satisfaction after a fitting with the reusable contact lenses :Bausch+Lomb ULTRA® for Presbyopia. 2.19 Bausch + Lomb ULTRA The contact lenses that bring you the ULTRA comfort experience without the premium cost. The ULTRA comfort experience. Comfort you would expect from a premium contact lens brand. Get all-day comfort The innovative contact lens technology that provides all-day comfort. Get all-day comfy eyes People give these lenses a thumbs up when it comes to all day comfort. Live the ULTRA life, with comfortable eyes for the whole waking day Comfort for the whole waking day! Merchea, M., Steffen, R., et al., 2014. Clinical performance of Bausch + Lomb ULTRA® contact lenses with MoistureSeal® technology silicone hydrogel. 2.20 Bausch + Lomb ULTRA These contact lenses stay moist for a full 16 hours Bausch + Lomb, 2013. 16 Hour bilateral dispensing evaluation of methacrylamide lenses as compared to Air Optix® Aqua, Acuvue® Oasys® and Biofinity® lenses. 2.21 Bausch + Lomb ULTRA And comfort day in, day out, for the whole month! Comfort for every waking day! Reindel, W., Mosehauer,G, et al.,2018. Patient comfort, vision and cleanliness over 12-months of samfilcon A Lens Wear. Poster presented at AAO. 2.22 Bausch + Lomb ULTRA People give high satisfaction scores for these monthly contact lenses. 9/10 agree these lenses are as comfortable at the end of the day as at the beginning 92% agree these reusable contact lenses are as comfortable at the end of the day as at the beginning 9/10 agree these contact lenses are better than their previous contact lenses Rah, M., et al., 2015. Interest and Acceptance of a New Contact Lens Technology in Today’s Practice. Poster presented at the American Optometric Association Annual. 2.23 Bausch + Lomb ULTRA for Presbyopia Goodbye reading glasses - these contact lenses can help with near, intermediate and far sight seamlessly. Clear sight for near, far, and intermediate distances People give high satisfaction scores for these monthly lenses for presbyopia How these contact lenses can help with near, far and in-between distances seamlessly Multifocal contact lenses that ensure comfortable eyes for the full waking day Seamless vision for distances near, far and everything in between Micromass, 2017. Bausch + Lomb ULTRA Comfort Experience for Presbyopia Final Results Report. 2.24 Bausch + Lomb ULTRA for Presbyopia 92% of eye care professionals agree these multifocal contact lenses give better end of day comfort for their customers. 92% of eye care professionals gave high end of day comfort scores for these multifocal contact lenses 9/10 eye care professionals gave high end of day comfort ratings for these contact lenses Galileo Business Consulting, 2019. Assessment of PATIENT satisfaction after a fitting with the reusable contact lenses: Bausch+Lomb ULTRA® for Presbyopia. 2.25 Bausch + Lomb ULTRA GO BEYOND COMFORT AND SEE EVERY DETAIL Reindel, W., et al.,2016. Use of digital devices and reports of dry eyes: Performance of a novel silicone hydrogel lens among contact lens wearers. Poster presented at the American Optometric Association Annual Meeting, Boston, MA, June. Steffen et al. New technology yields dehydration resistance. Poster presented at the American Academy of Optometry Annual Meeting, Denver, Colorado, November, 2014 Hoteling et al. Characterization and quantitation of PVP content in a silicone hydrogel contact lens produced by dual-phase polymerization processing. J Biomed Mater Res Part B: Appl Biomater (2018), 106B: 1064–1072. 2.26 Bausch + Lomb ULTRA When you're passionate, every detail matters. Go beyond what you thought possible and achieve ultra-performance with 16 hours of comfort. For 16 hours of comfort: Schafer et al. Use of a novel extended blink test to evaluate the performance of two polyvinylpyrrolidone containing, silicone hydrogel contact lenses. Clinical Ophthalmology 2018:12 819–825. For Ultra performance: Reindel et al. Use of digital devices and reports of dry eyes: Performance of a novel silicone hydrogel lens among contact lens wearers. Poster presented at the American Optometric Association Annual Meeting, Boston, MA, June 2016 # PRODUCT CLAIM REFERENCE 3.1 Biotrue ONEday Bausch + Lomb Biotrue® ONEday, the contact lens with the most moisture 78% water content More moisture than any other lens** **Among daily disposable contact lenses **Compared to other daily disposable lenses in the market Biotrue® ONEday start and end the day with more moisture than leading daily disposables 1. ACLM, 2021. ACLM Year Book Online. 3.2 Biotrue ONEday Biotrue® ONEday uses a revolutionary Surface Active TechnologyTM Dehydration Barrier: PVP and Poloxamer 407 are permanently enriched at the surface, locking in the high water content and providing a smooth optical surface3,14 2. Bausch + Lomb, 2011. Hypergel Surface Characterisation Memo, Rochester. 3.3 Biotrue ONEday locks in nearly 100% moisture for 16 hours*3 * 98% for 16 hours. Percentage of water calculated to decreased lens mass due to water loss 16 hours of moisture Maintains 98% moisture More moisture from morning to night*+3 +Compared to other daily disposable lenses in the market. 3. Bausch + Lomb, 2012. A clinical evaluation of Biotrue® ONEday compared to 1-DAY ACUVUE® MOIST ®, 1-DAY ACUVUE® TruEye® and DAILIES® AquaComfort PLUS® dehydration data preliminary results and claims support (ROC2-11-63). Rochester. 3.4 Biotrue ONEday More stable tear film* Longer mean tear film break up time*4 Provides the highest tear film stability of leading daily disposables*4 Biotrue® ONEday has the longest average Tear Break Up Time - outperforming competitors by up to +50%* Superior Pre-Lens Tear Film Stability after 10 hours of lens wear* *Compared to other daily disposable lenses in the market. 4. Tomy, L., Chan, O., Reindel, B., Steffen, R., January 2020. Non-Invasive Tear Break-Up Time Evaluation of Six Unique Daily Disposable Lens Materials After 10 Hours of Wear. Global Specialty Lens Symposium. 3.5 Biotrue ONEday maximum comfort for patients. More moisture makes a more comfortable lens. Delivers consistent vision throughout the day Biotrue® ONEday keeps eyes healthy and white SPHERICAL ABERRATION CONTROL Designed to help reduce halos and glare 85% of patients agreed the overall moistness of eyes while wearing Biotrue® ONEday was Good to Excellent 92% of patients agreed that Biotrue® ONEday contact lenses are comfortable throughout the day 84% of patients agreed that the lenses delivered comfortable vision throughout the day when looking for a long time at a smartphone or tablet 5. Bausch + Lomb, 2012. A study to evaluate the product performance of a daily disposable soft contact lens (#700). Rochester. 3.6 Biotrue ONEday for Presbyopia 4 out of 5 patients successfully fit in just one visit*. 96% of patients successfully fitted in two visits*. 80% of patients successfully fitted in one visit*. *When the ECP followed the fitting guide Patients agree lenses featuring 3-Zone Progressive Design™ provide clear vision when: using a computer – 96% using a mobile phone -96% reading printed material- 93% driving during the day-93% doing physical activities- 93% at the end of the day- 94% 6. Bausch + Lomb, 2013. Perceptions of Bausch + Lomb PureVision® 2 for Presbyopia (#815). 3.7 Biotrue ONEday for Presbyopia patients will experience high levels of satisfaction with the excellent near, intermediate and distance vision for real world tasks.6,7 92% of eyecare professionals agreed that using the fitting guide made lenses with 3-Zone Progressive Design™ easy to fit* *When the ECP followed the fitting guide 7. Wright, M., et al., 2016. Capturing the presbyopic opportunity. Review of Optometric Business. 3.8 Biotrue ONEday 40% of contact lens wearers want a lens with a high moisture level 8. Gallup., 2017. Study of the US Consumer Contact Lens Market. 3.9 Biotrue ONEday 60% would like to be able to wear their lenses longer 9. Assottica Gruppo contattologia., May 2018. Italy. 3.10 Biotrue ONEday 53% wish their lenses were more comfortable 10. Assottica Gruppo contattologia., May 2018. Italy. 3.11 Biotrue ONEday Moisture is so important because you want to avoid getting dry eyes at the end of the day 11. Compredo Research., February 2019. Qualitative Research Findings in UK. 3.12 Biotrue ONEday More breathability#12,40,41 Superior Breathability#12,40,41 # Dk/t vs DAILIES®AquaComfort PLUS® and1-Day ACUVUE® Moist UVA / UVB protection+12 Blocks more than 50 % of harmful UVA rays and more than 90 % of UVB rays. +UV-absorbing contact lenses are NOT substitutes for UV-absorbing sunglasses. You should continue to use UV absorbing sunglasses as directed. 12. Bausch + Lomb, 2012. Bausch + Lomb nesofilcon A contact lens (#510(k) Summary). Rochester 3.13 Biotrue ONEday The natural tear film is largely responsible for everyday visual comfort. Dry eyes are often a result of unstable tear film that breaks up, reducing its ability to keep the water from evaporating 13. Craig, J.P., et al., 2017. TFOS DEWS II Report Executive Summary. The Ocular Surface journal homepage 3.14 Biotrue ONEday Tear film serves to: Protect and lubricate the eyes Reduce the risk of eye infection Wash away foreign particles Providing a smooth optical surface. 14. Bron, A.J., Tiffany, J.M., Gouveia, S.M., Yokoi, N., Voon, L.W., 2003. Functional Aspects of the Tear Film Lipid Layer. Experimental Eye Research, 78 (2004), pp.347-360. 3.15 Biotrue ONEday Split tear film causes quicker tear film evaporation. 15. Buch, J., Canavan, K., Fadli, Z., et al., 2016. The tear film and contact lens wear: Part of the challenge of achieving comfortable contact lens wear is to mimic the functions of the tear film. Contact Lens Spectrum, 31, pp.34-37 3.16 Biotrue ONEday When a contact lens is inserted, it splits the tear film and causes the tear film to evaporate more quickly. This can lead to discomfort and poor visual quality.16,17 16. Craig, J.P., Willcox, MDP., Argueso, P., et al., 2013. The TFOS international workshop on contact lens discomfort: report of the contact lens interactions with the tear film subcommittee. Investigative Ophthalmology & Visual Science, 54(11), pp.123-156 17. Nichols, J., Sinnot, L.T., 2006. Tear Film, Contact Lens, and Patient-Related Factors Associated with Contact Lens-Related Dry Eye. Investigative Ophthalmology & Visual Science, 47(4), pp.1319-1328 3.17 Biotrue ONEday Dryness, discomfort and poor visual performance are the main causes of contact lens dissatisfaction, decreased wearing time and discontinuation18 and result from “reduced compatibility between the contact lens and the ocular environment”.19 18. Kadence International, 2013. Exploring Contact Lens Drop-Off 19. Nichols, K.K., et al., 2013. The TFOS International Workshop on Contact Lens Discomfort: Report of the Definition and Classification Subcommittee. The Association for Research in Vision and Ophthalmology, Inc 3.18 Biotrue ONEday Contact lenses must retain moisture to preserve tear film stability, prevent light scatter and optical aberrations, retain lens shape and minimise friction that lead to discomfort.19,20,21 20. Schafer, J., Steffen, R., Reindel, W., et al., 2015. Evaluation of surface water characteristics of novel daily disposable contact lens materials, using refractive index shifts after wear. Clinical Ophthalmology, 9, pp. 1973-1979. 21.Montani, G., Giuffrida, S. and Carla, F., 2016. Effects of three different daily disposable contact lenses on prelens tear film. Poster Presentation. [Tear Film & Ocular Surface (TFOS) Conference Program & Abstract Book] 3.19 Biotrue ONEday Surface Active TechnologyTM preserves stable tear film.4,22 Because a well-functioning and stable tear film is critical to visual comfort, Biotrue® ONEday lenses feature Surface Active Technology, a formula designed to mimic the eye’s natural tear film 22. Schafer J, et al. Comparing On Eye Dehydration and Corneal Staining of Three Daily Disposable Contact Lenses in a Low Humidity Environment. Presented during the 2012 meeting of the British Contact Lens Association. Birmingham, England 3.20 Biotrue ONEday A patented dehydration barrier helps the lens maintain its shape 23. Lee, R.H., Fahy, K., Richardson, G., 2012. Understanding Lens Shape Dynamics During Off-Eye Dehydration of Contact Lens Materials with Varying Water Contents. BCLA Poster Presentation #32. Birmingham 3.21 Biotrue ONEday Provides even more oxygen than the open eye needs to remain healthy and white 24. Barr, J., Donnelly, C., Rah, M.J. Measuring Oxygen Transmissibility: How Much is Enough for Healthy Contact Lens Wear? 3.22 Biotrue ONEday People may blink up to 66% less when using a digital device25 which exposes the lens surface for a longer period of time and increases the possibility for dry and tired eyes.26 25. Rah, M., 2016. Blink Rate Review. Rochester 26. Patel, S., et al., 1991. Effect of visual display unit use on blink rate and tear stability. Optometry and Vision Science,68 (11), pp. 888-892 3.24 Biotrue ONEday for Astigmatism 97% of patients experienced rotation of 10˚or less at dispensing 98% of ECPs were satisfied with the speed of fitting 91% of patients had consistent lens stability 27. Bausch + Lomb, 2016. A study to evaluate product performance of two designs of soft toric lenses (# 828:15-003). Rochester 3.25 Biotrue ONEday for Astigmatism Consistently Clear and Stable Vision28,29,30 Designed for comfort and stability 28,29,30 PERI-BALLAST DESIGN An evolved, blink-inspired, prism free, peri-ballast lens designed for consistently clear and stable vision28,29 SPHERICAL ABERRATION CONTROL in both axes for sharp vision and a reduction in halos and glare28,30 28. Bausch + Lomb, 2016. A study to evaluate product performance of two designs of soft toric lenses (# 828:15-003). Rochester. 29. Bausch and Lomb, 2016. Biotrue® ONEday for Astigmatism (nesofilcon A Toric) Design Description. (#LDR165005). Rochester 30. REF-BFA-0017-BODFA Spherical Aberration Correction_WRD-16-050R-Rev1 Report 3.28 Biotrue ONEday for Astigmatism 96% of patients are satisfied with Biotrue® ONEday for Astigmatism 31.Saxon, J., Rah, M., Reindel, W. Satisfaction of astigmatic patients with toric nesofilcon A contact lenses. Rochester, NY 3.29 Biotrue ONEday for Presbyopia Biotrue® ONEday for Presbyopia daily disposable multifocal lens has a 3-Zone Progressive Design™ to help your patients see clearly and comfortably up close, far away, and in between.32, 6, 33, 34 32. Bausch + Lomb., 2016. Statistical Analysis of Biotrue® ONEday For Presbyopia Patient Survey. (n=261). 33. Optical Design and Power Profiles for Biotrue ONEday for Presbyopia, Rochester NY, 2013 34. Vogt, A.K.S., Hovinga, K.R. Introducing a New Technology in Multifocal Lenses. Satisfy your patients at all distances. ContactLens SPECTRUM MARCH 2014 3.34 Biotrue ONEday for Presbyopia Seamless: Smooth transition across 3 zones for easy adaptation between key distances35,36 35. Optical Design and Power Profiles for Biotrue ONEday for Presbyopia, Rochester NY, 2013 36. Vogt, A.K.S., Hovinga, K.R., 2014. Introducing a New Technology in Multifocal Lenses. Satisfy your patients at all distances. Contact Lens SPECTRUM 3.36 Biotrue ONEday for Presbyopia 3 distinct zones each with consistent power Stable power profile across the lens for all powers Accurate add power at every power 37. AAO 2014_Consistency of MF CL Designs Poster. Biotrue ONEday for Presbyopia Rosa Lee / Vogt, A.K.S., Hovinga, K.R. Consistency of Multifocal Contact Lens Design. Poster Presentation 3.37 Biotrue ONEday for Astigmatism The ONLY daily toric with a -2.75D cyl* * Excluding made-to-order lenses. 38. Based on a comparison of manufacturer-provided parameter ranges on May 21st 2020. 3.38 Biotrue ONEday Spherical aberration control to reduce halos and glare, even in low-light conditions5,38 39. Lee, R., 2013. Verification of Aspheric Optics on Biotrue ONEday SVS (nesofilcon A) Lenses (#LDR 137006). Rochester. 3.39 Biotrue ONEday More breathability Higher Dk/t#12,40,41 40. Alcon Manufacturer-provided information, November, 2019 3.40 Biotrue ONEday More breathability Higher Dk/t#12,40,41 41. Johnson & Johnson Visioncare Manufacturer-provided information., November 2019 # THEME CLAIM REFERENCE 4.1 Biotrue MPS 9 out of 10 who considered stopping lens wear, significantly reduced their likelihood of dropping out of contact lens wear after using Biotrue® multi-purpose solution for just 2 weeks Rah, M., et al., 2014. Reducing dropout of contact lens wear with Biotrue® multipurpose solution. Clinical Ophthalmology, 8, pp. 293-299. 4.2 Biotrue MPS Dual disinfection system contains an optimal combination of two disinfectants Biotrue®multi-purpose solution package insert. 4.3 Biotrue MPS Offers unsurpassed disinfection efficacy* (*All soak times as per manufacturer recommended minimum soak time.) David, B., et al. Evaluation of multipurpose solutions for in vitro biocidal efficacy against a challenge of ocular clinical isolates including methicillin resistant staphylococcus aureus and methicillin-resistant staphylococcus epidermidis strains. Rochester. 4.4 Biotrue MPS Conditions An innovative protein management system to maintain natural tear protein function Wright, E.A., et al,2012. Preservation of human tear protein structure and function by a novel contact lens multipurpose solution containing protein stabilizing agents. Eye & Contact Lens, 38(1),pp.36-42. 4.5 Biotrue MPS Delivers patient convenience when cleaning with just a 4 hour soak time to achieve clean lenses Biotrue® multi-purpose solution package insert. 4.6 Biotrue MPS Advanced formulation contains the wetting agent hyaluronan for continuous patient comfort Scheuer A. C., 2009 . Adsorption and Controlled Release of a Polysaccharide Conditioning Agent from Soft Contact Lenses. Rochester. 4.7 Biotrue MPS Advanced formulation contains the wetting agent hyaluronan for continuous patient comfort Millward Brown., 2010. Biotrue® Product Test (#640). 4.8 Biotrue MPS Rehydrate - provides up to 20 hours of moisture to cushion and rehydrate your lenses for comfortable wear throughout the day Scheuer A. C., 2009 . Adsorption and Controlled Release of a Polysaccharide Conditioning Agent from Soft Contact Lenses. Rochester. 4.9 Biotrue MPS Rehydrate - provides up to 20 hours of moisture to cushion and rehydrate your lenses for comfortable wear throughout the day Millward Brown., 2010. Biotrue® Product Test (#640). 4.10 Biotrue MPS 90% say that Biotrue keeps their lenses feeling clean throughout the day Bausch + Lomb, 2008. A study to evaluate the product performance of Bausch + Lomb BL-3100 BPZ02 multi-purpose solution compared to Alcon Opti-Free Replenish multi-purpose solution when used with silicone hydrogel contact lenses worn on a daily wear basis (#562). Rochester. 4.11 Biotrue MPS 87% say that Biotrue keeps their eyes feeling healthy Bausch + Lomb, 2008. A study to evaluate the product performance of Bausch + Lomb BL-3100 BPZ02 multi-purpose solution compared to Alcon Opti-Free Replenish multi-purpose solution when used with silicone hydrogel contact lenses worn on a daily wear basis (#562). Rochester. 4.12 Biotrue MPS 82% say that Biotrue provides continuous comfort Millward Brown., 2010. Biotrue® Product Test (#640). 1 Biotrue MPS Make wearing contact lenses easier for your patients Provides comfort and moisture A great/positive contact lens experience, based on comfort, moisture and cleanliness Your patients need comfort, cleanliness and moisture Hydrates Millward Brown., 2010. Biotrue® Product Test (#640). 2 Biotrue MPS Biotrue® Multi-Purpose Solution works like the eye With a dual disinfection system Developed to work like your eyes Biotrue® multi-purpose solution instructions for use 3 Biotrue MPS The solution supports inherent antimicrobial activity Wright, E. A., et al., 2012. Preservation of human tear protein structure and function by a novel contact lens multipurpose solution containing protein-stabilising agents. Eye & Contact Lens, 38(1), pp. 36-42. 4 Biotrue MPS With its protein management system M. Jones, A. YaYa, D. Heiler, Protein Removal Study with Biotrue Multi-Purpose Solution. Rochester, NY. 2016. 5 Biotrue MPS Provide your patients with up to 20 hours of moisture C.A. Scheuer et al., Retention of conditioning agent hyaluronan on hydrogel contact lenses. Rochester, NY. 2010 6 Biotrue MPS Killing harmful microorganisms on the lens avid B., Callaham D., McGrath D., Strassburg J., Hilfiker T and Tackabury J., An evaluation of the rate of disinfection of various multi-purpose solutions and a hydrogen peroxide solution using the ISO 14729. Rochester, NY 7 Biotrue MPS Matching the pH of healthy tears Is pH balanced to match healthy tears Burke, S.E., Fridman, K.M., Scheuer, C.A., Barniak, V.L. Physical properties of multipurpose contact lens care solutions. Rochester, NY. 2010. # THEME CLAIM REFERENCE 5.1 Lens Care compliance 85% of patients perceive themselves to be compliant with lens wear and care good practice, but only 2% of these patients actually meet the recommended safety levels Robertson, D.M., and Cavanagh, H.D, 2011, Optom Vis Sci. [e-journal] 88(12), pp 1402-1408. Available through National Centre for Biotechnology Information website https://www.ncbi.nlm.nih.gov/p... [Accessed 01 July 2020]. 5.2 Lens Care compliance 92% of consumers seek lens care compliance info from their ECP or in practice Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.3 Lens Care compliance 72% of consumer do not follow five key steps of a compliant lens care regime Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.4 Lens Care compliance 67% don’t rinse their lenses with fresh solution every time before insertion Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.5 Lens Care compliance 60% don’t leave their contact lenses every time to soak overnight Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.6 Lens Care compliance 55% don’t place their cleaned lenses into the lens case with fresh solution every time Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.7 Lens Care compliance 66% don’t always thoroughly rinse each side of the contact lens after rubbing and before storing Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.8 Lens Care compliance 72% don’t always place drops of solution onto the contact lens and rub each side of the lens to clean it and remove dirt or debris Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.9 Lens Care compliance A third of wearers use something other than contact lens solution to clean their lens case: 27% use water 14% use saline 13% use water and soap / detergent Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.10 Lens Care compliance 75% of wearers clean their contact lens case less frequently than daily Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.11 Lens Care compliance 8% of wearers never clean their lens case at all Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.12 Lens Care compliance Good cleaning ability ranks as the top reason why a patient is happy with their current contact lens solution (55%) Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.13 Lens Care compliance 35% are satisfied with their contact lens solution because it improves their contact lens comfort Opinion Health, 2019. Lens Care Solutions Study. United Kingdom. 5.14 Lens Care compliance Half of contact lens patients experience frequent discomfort and on average in in every four drop out of contact lens wear entirely Bickle, K., Nichols, K., 2014. Contact lens discomfort defined. Contact Lens Spectrum/Special Edition, pp.18-22. # THEME CLAIM REFERENCE 6.1 ReNu MPS Gently cleans, rinses, lubricates, disinfects and stores soft contact lenses, including silicone hydrogels Bausch + Lomb, 2006. A study to compare ReNu®Multi-purpose solution vs Alcon Opti-Free Express® Multi-purpose solution when used with silicone hydrogel lenses worn on a daily wear basis (#497). Rochester. 6.2 ReNu MPS It helps keep sensitive eyes comfortable with a solution as gentle as one’s natural tears Bausch + Lomb, 2006. A study to compare ReNu®Multi-purpose solution vs Alcon Opti-Free Express® Multi-purpose solution when used with silicone hydrogel lenses worn on a daily wear basis (#497). Rochester. 6.3 ReNu MultiPlus MPS ReNu® MultiPlus solution effectively disinfects lenses - contains DYMED™, providing superior disinfecting efficacy (exceeds ISO standalone procedure log reduction values) and effectively kills micro-organisms on the lens Bausch + Lomb, 2006. Proven performance in soft lens care. 6.4 EasySept Removes protein Bausch + Lomb, 2009. ISO/FDA stand alone procedure for disinfecting products of BL-3100-EZS05 after 7 months of storage at 25°C and 40°C (RO637). Rochester. # THEME CLAIM REFERENCE 7 General Wearing contact lenses can have many benefits, and when cared for properly, can provide a comfortable and convenient way to work, play, and live for the approximately 140 million people who wear them globally Nichols, J., Willcox, M., Bron, A., et al, 2013. The TFOS International Workshop on Contact Lens Discomfort: Executive Summary. Invest Opthalmol Vis Sci. 54, TFOS7-TFOS13. SUBSCRIBE TO OUR NEWSLETTER AND RECEIVE REGULAR, RELEVANT UPDATES SUBSCRIBE BAUSCH & LOMB INCORPORATED All information and materials on this site pertain to the U.K. only, unless otherwise indicated. 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