About Products & Pipeline Partnering Investors & News Blog Mytesi Mytesi® (crofelemer), a product of Jaguar’s wholly-owned subsidiary Napo Pharmaceuticals, is approved by the FDA for the symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy. More information and complete Prescribing Information are available at Mytesi.com. Mytesi is a novel, first‑in‑class anti‑secretory agent which has a basic normalizing effect locally on the gut, and this mechanism of action has the potential to benefit multiple gastrointestinal disorders. Jaguar, through Napo, holds extensive global rights for Mytesi. Mytesi is in development for multiple possible follow‑on indications, including diarrhea related to targeted cancer therapy; orphan‑drug indications for infants and children with congenital diarrheal disorders and short bowel syndrome; supportive care for inflammatory bowel disease; irritable bowel syndrome; and for idiopathic/functional diarrhea. In addition, a second‑generation proprietary anti‑secretory agent is in development for cholera. Crofelemer, the active ingredient in Mytesi®, is a botanical (plant-based) drug extracted and purified from the red bark sap of the medicinal Croton lechleri tree in the Amazon rainforest. Napo has established a sustainable harvesting program for crofelemer to ensure a high degree of quality and ecological integrity. Important Safety Information: MYTESI® is an antidiarrheal indicated for the symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy (ART). MYTESI® is not indicated for the treatment of infectious diarrhea. Read More… © Copyright 2020 Jaguar Health Contact Us | Careers | Legal Notice | Privacy Policy | Social Media Policy | Website Accessibility Feedback Email | Web Accessibility Feedback Form | Admin |

About Products & Pipeline Partnering Investors & News Blog This form is for Website Accessibility Feedback. For product information, adverse event reports, and product complaints, please contact Napo Pharmaceuticals product.inquiries@napopharma.com | (844) 722-8256 You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. Name* First Last Email* Feedback* © Copyright 2020 Jaguar Health Contact Us | Careers | Legal Notice | Privacy Policy | Social Media Policy | Website Accessibility Feedback Email | Web Accessibility Feedback Form | Admin |