Home About Clinicians Patients Investors Careers Media Contact Clinicians > About SIR-Spheres microspheres > Potential adverse events Almost all treatments and drugs produce potentially unwanted side effects. Most side effects following a SIRT procedure are minor., making patients feel uncomfortable, but a small number can be serious. Every patient is different in how he or she reacts to a treatment. Patients may experience abdominal pain or tightness in their abdomen, nausea and loss of appetite which normally subsides within a week after treatment mild fever that may last for up to a week fatigue, which may last for several weeks post-treatment. As a precaution, specific peri-procedural medications are prescribed to control these symptoms. In rare instances, there is a possibility that microspheres may inadvertently reach other organs in the body, such as the gallbladder, stomach, intestine, or pancreas. If SIR-Spheres® Y-90 resin microspheres reach these organs, they may cause cholecystitis, gastritis, duodentitis or pancreatitis. These complications are rare, but if they do occur they may require additional medical treatment. Between 60 and 90 days post treatment, there is also a small risk of radioembolisation induced liver disease (REILD) which is characterised by jaundice, ascites and elevated bilirubin levels. For more information please see Approved Indication. DOORwaY-90 Study International Recommendations FLEXdose Delivery Programme About SIRT About SIR-Spheres microspheres Mode of Action How are SIR-Spheres microspheres administered Patient Selection Potential adverse events Radiation Safety Aspects Follow Up Peri-Procedural Medications - mCRC Clinical Studies + HCC Clinical Studies + Ongoing Clinical Studies Customer Support and Training Programs Events Frequently Asked Questions Who we are Sirtex Medical is a global healthcare business with offices in the U.S., Australia, Germany and Singapore, working to improve outcomes in people with cancer. Our current lead product is a targeted radiation therapy for liver cancer called SIR-Spheres® Y-90 resin microspheres. What are SIR-Spheres® Y-90 resin microspheres? SIR-Spheres® Y-90 resin microspheres are a medical device used in Selective Internal Radiation Therapy (SIRT) for treatment of unresectable hepatocellular carcinoma (HCC) and unresectable metastatic liver tumors from primary colorectal cancer in patients refractory to or intolerant of chemotherapy. To view the Technical Bulletin regarding our indication, click here. Contact or follow us Contact Us SIR-Spheres® is a registered trademark of Sirtex SIR-Spheres Pty Ltd. Terms of Use | Privacy Information 892-EUA-1117