CAPABILITIES CATALOG NEWS AND PUBLICATIONS ABOUT CONTACT US INFLAMMATION Inflammation is a response to a variety of stimuli, including damaged cells, irritants and pathogens, and is relevant for many different indications. Porsolt’s varied capabilities and expertise, together with multiple in vitro and in vivo models used for screening, efficacy, and safety assessment of potential compounds, allows us to address the specific needs of the industry. INFLAMMATION CAPABILITIES SCROLL INFLAMMATORY DISEASE Immune Response In Vivo Models INFLAMMATION PUBLICATIONS BIOMARKER ASSAYS Porsolt Z.A. de Glatigné 53940 Le Genest-Saint-Isle, France Telephone +33 2 43 69 36 07 LinkedIn Legal Notice Any questions or concerns ? CONTACT US © COPYRIGHT - PORSOLT 2021

CAPABILITIES CATALOG NEWS AND PUBLICATIONS ABOUT CONTACT US CENTRAL NERVOUS SYSTEM Porsolt offers models in all areas of psychopharmacology, epilepsy, sleep-wake, and neurodegenerative disorders. We are uniquely placed to offer a full range of CNS efficacy and safety pharmacology assessments, from basic models and regulatory tests, to the evaluation of abuse and dependence liability and proconvulsant risk using EEG. CENTRAL NERVOUS CAPABILITIES SCROLL CENTRAL NERVOUS SYSTEM DISEASE CNS General Screening Cognition & Aging Drug Abuse & Dependence Electrophysiology Epilepsy Neurodegeneration Psychiatric Diseases Stroke CENTRAL NERVOUS SYSTEM PUBLICATIONS BIOMARKER ASSAYS Porsolt Z.A. de Glatigné 53940 Le Genest-Saint-Isle, France Telephone +33 2 43 69 36 07 LinkedIn Legal Notice Any questions or concerns ? CONTACT US © COPYRIGHT - PORSOLT 2021

CAPABILITIES CATALOG NEWS AND PUBLICATIONS ABOUT CONTACT US THROMBOSIS Porsolt provides models for assessing the effects of compounds and potential therapies on blood flow. These models can be used for investigating direct effects or confounding and side effects of specific treatments on blood flow. THROMBOSIS CAPABILITIES SCROLL THROMBOSIS IN VITRO MODELS Endothelial cell activation/ Drug-Induced Vascular Injury (DIVI) HUVECs cells IN VIVO MODELS Arterial thrombosis (FeCl2) Rat Arterio-venous shunt (silk thread model) Rat Bleeding time (anesthetized animal) Rat Venous thrombosis (FeCl2) Rat THROMBOSIS PUBLICATIONS BIOMARKER ASSAYS Porsolt Z.A. de Glatigné 53940 Le Genest-Saint-Isle, France Telephone +33 2 43 69 36 07 LinkedIn Legal Notice Any questions or concerns ? CONTACT US © COPYRIGHT - PORSOLT 2021