WHAT'S TISCH? RESEARCH STEM CELL TRIAL NEWS TEAM TISCH GET INVOLVED SEARCH DONATE Anna Iacoangeli, PhD “The close collaboration between scientists and clinicians has been the primary motivation for joining the Tisch MSRCNY. The daily interaction with patients is a constant reminder that our ultimate goal is translating scientific discoveries into novel therapeutic interventions that will prevent MS progression.” - Dr. Anna Iacoangeli, Assistant Research Scientist Dr. Iacoangeli joined the Tisch Multiple Sclerosis Research Center scientific team in 2017. Prior to her appointment at the Center, she served as a Research Assistant Professor at SUNY Downstate Health Science University in Brooklyn. Dr. Iacoangeli’s research interests have focused on understanding the molecular functions of a subtype of regulatory non-coding RNAs (ncRNAs) in neuronal processes and mechanisms. She published that dysregulation of these RNAs at synapses resulted in cognitive impairment. In her clinical research at SUNY Downstate, Dr. Iacoangeli identified a novel RNA-based biomarker for invasive breast cancer diagnosis and prognosis. At the Tisch MS Research Center, Dr. Iacoangeli’s research emphasis is on investigating cerebellar dysfunction in multiple sclerosis. Clinical cerebellar manifestations experienced by MS patients, consisting of tremor, motor coordination deficits, and slurred speech, result in a significant impairment. Dr. Iacoangeli’s research team has developed a novel mouse model to study cerebellar dysfunction in MS. Her current results suggest that the underlying mechanisms of cerebellar manifestations in MS are based on alteration of neurotransmission at the synapses. Understanding the causes of cerebellar dysfunction will translate into effective and tailored treatment strategies for MS patients. Dr. Iacoangeli and her team have presented these findings at the American Academy of Neurology and at the Society for Neuroscience annual meetings. Dr. Iacoangeli received her Ph.D. in Applied Genetics and her Master in Biological Sciences from the Department of Genetics and Molecular Biology “Charles Darwin”, at the Sapienza University of Rome, Italy. Dr. Iacoangeli works with research assistant Mia DiCostanzo (BA from Vassar College). 2019 ABSTRACTS Novel Mouse Model to Study Cerebellar Dysfunction in Multiple Sclerosis A Study of Long Noncoding RNAs Expression Levels in the CSF of Multiple Sclerosis Patients Click here to view all abstracts Tisch MS Research Center of New York 521 West 57th Street 4th Floor New York, NY 10019 (646) 557-3900 Privacy Policy Tisch MS News Tisch MSRCNY Holiday Closing Research Priorities at Tisch MSRCNY Happy Veterans Day! More » Support Tisch MS Support Tisch MS and our innovative research leading to treatments that improve the lives of patients. DONATE Safe & Secure This is the website of the Tisch MS Research Center of New York, a non-profit, 501(c)(3), independent, multiple sclerosis research center, and not a medical practice. CLICK HERE to be directed to our clinical affiliate, the International Multiple Sclerosis Management Practice. 521 West 57 St., 4th Flr, NY, NY 10019 | ©2017 Tisch MS All rights reserved. We use cookies on this site to enhance your user experience By clicking the Accept button, you agree to us doing so. No, give me more info OK, I agree