Test Catalog Ordering Insurance & Billing Test Results Investigate Variants Register Sign In IntelliTest Manager Contact About Us Investigate Variants Athena InsightTM: Finding Color in a World of Gray Results You hear them every day. The questions patients ask. What’s causing my symptoms? Why did this happen to me? What are the chances that I can pass this onto my children? The answers aren’t always clear. When it comes to a genetic diagnosis, you want the most reliable, up-to-date, understandable information. We understand your challenge. We understand your quest for insight. When a variant of unknown significance (VUS) is found, we know that the interpretation is not always straight forward. That’s why we’ve developed Athena Insight™, a process for determining the significance of genetic variants. Athena Insight™ is a team of highly trained scientists whose primary focus is to assess the pathogenicity of genetic variants identified in patients. To achieve this goal, we conduct a thorough investigation of published research which is then integrated with data from an internal dataset, external databases, research collaborations and clinician-provided phenotypes. A comprehensive and objective assessment of the data is made by utilizing a standardized, rules-based algorithm resulting in a final pathogenicity assessment score. Close collaboration among our scientists, genetic counselors and clinical laboratory directors ensures that all the relevant information has been collected and systematically analyzed in order to provide the most clinically-informative result to our clients. We understand your goals, and we work with you. Our high-touch approach optimizes the value of modern science and human insight. We look for color in a world of gray results. Please use the form below if you would like to request a variant update. Accession (required): Variant(s): Preferred method of contact (required): Phone E-mail Phone number: E-mail: Contact name (required): Select one (required): Physician Genetic counselor Clinical staff Patient Other Please note that patients initiating variant update requests will have the variant information returned to the ordering physician. Comments: General comments may be emailed to AthenaInsight@questdiagnostics.com. Resources Family Insight Program Letter Family Insight Program Application Form Family Insight Program Patient Consent Form Family Insight Program Family Member Consent Form Example of VUS report module Webinar: Standardized DNA Variant Scoring System for Pathogenicity Assessments: Application in a Diagnostic Lab Setting New Publication Article detailing the pathogenicity assessment process Athena Diagnostics is a leader in diagnostic testing for neurological diseases and offers innovative tests for Alzheimer's disease, muscular dystrophy and other neuromuscular and developmental disorders. View Full Catalog About Us Accreditations and Licensing Patents Held Careers Copyright © 2021 Athena Diagnostics, Inc. All trademarks and service marks identified by ®, ™ or ℠ symbols or appearing in type form different from that of the surrounding text are marks owned by or licensed to Athena Diagnostics, Inc., its subsidiaries or affiliates, unless otherwise identified as being owned by another entity. See Full Notice Genetic Testing Policies Cookies Notice Privacy Shield Privacy Terms DO NOT SELL MY PERSONAL INFORMATION Language Assistance / Non-Discrimination Notice Asistencia de Idiomas / Aviso de no Discriminación 語言協助 / 不歧視通知 200 Forest Street, 2nd Floor Marlborough, MA 01752 Phone (508) 756-2886 Need Help?