News & events Insight & resources Facilities Careers Contact Drug substance Drug product Analytical services Open Search Robert Jake Dam Associate Scientist II Analytical Services Analytical solutions Quality assured Find out more about our extensive experience in bioanalytical and biopharmaceutical analysis Bioanalytical & biopharmaceutical analysis Cambrex has extensive experience in Drug Metabolism and Pharmacokinetic (DMPK), Bioanalytical and Biopharmaceutical Analyses. The Biopharmaceutical Analyses scope supports GMP method development, validation, and routine analysis including but not limited to host cell proteins, host cell DNAs, endotoxins, enzyme kinetics, and even bacteriophage titering assays. The Drug Metabolism and Pharmacokinetic (DMPK) scope supports pre-clinical discovery and development utilizing state-of-the-art instruments including High Resolution and LC-MS/MS. In addition, Cambrex has experience with metabolite identification (ID) from such studies. Cambrex Biopharmaceutical Analyses Advanced Biopharmaceutical Method Development Method Validation (GMP) and Method Qualification (non-GMP) Protocols and Execution Stability Protocols and Execution Routine Sample Analyses (GMP and R&D) GMP Bacteriophage Titering, and SDS page (ChemiDoc) Host Cell Protein (Microplate based with Western Blot Coverage for mid- to late- phase programs) Host Cell DNA (qPCR) Endotoxins (USP<85>), Enzyme Kinetics, Total RNA, Total Protein, and ELISAs (Microplate reader) Cambrex DMPK – Bioanalytical Services ADME Hepatocyte Stability Microsomal Stability S9 Stability Plasma Stability Simulated Fluid Stability Tissue Stability Reactive Metabolite Assessment (Glutathione Trapping) Metabolite Identification (in vitro and in vivo) CYP Inhibition PAMPA Franz Diffusion Cell Permeability Tissue Binding Microsomal Protein Binding Plasma Protein Binding Whole Blood Binding Blood to Plasma Ratio (in vitro and in vivo) Blood/Plasma to Tissue Ratio Bioanalysis Advanced Bioanalytical Method Development Pharmacokinetics (PK) Services In vivo Protocol Drafting In vitro – in vivo Correlation Cassette Dosing and Analysis (N-in-one) Pre-Formulation to Enable in vivo Work Non-clinical PK Management and Data Interpretation Integrated Services Hit-to-lead and Lead Optimization Get in touch with Cambrex To learn more about our bioanalytical and biopharmaceutical services, get in touch with the Cambrex team via our contact page. Contact Us Analytical services Speak to one of our experts About us Cambrex provides drug substance, drug product and analytical services across the entire drug lifecycle Quality & regulatory We deliver quality in every aspect of our work, across all of our facilities, systems and teams Environment, health & safety Our strong commitment to the environment and health and safety underpins all that we do at Cambrex Cambrex careers At Cambrex, it’s our people that set us apart. We’re committed to attracting, nurturing and retaining a passionate and talented team of experts that enjoy what they do Contact About Recruitment policy Privacy Sitemap Forms & Certificates Manage Cookies © 2007-2021 Cambrex Corporation. All rights reserved. This site uses cookies to store information on your computer. Some of these cookies are essential, while others help us to improve your experience by providing insights into how the site is being used. AcceptDecline Necessary Cookies Necessary cookies enable core functionality such as page navigation and access to secure areas. The website cannot function properly without these cookies, and can only be disabled by changing your browser preferences. Analytical Cookies Analytical cookies help us to improve our website by collecting and reporting information on its usage. Analytical Cookies On Off Marketing Cookies We use marketing cookies to help us improve the relevancy of advertising campaigns you receive. Marketing Cookies On Off Save and close