HOME MAJOR NEEDS SCIENCE PRODUCTS PEOPLE PRESS INVESTORS CAREERS REGION USING BIOMIMICRY TO TREAT THE GENESIS OF OBESITY & GI-RELATED CHRONIC DISEASES We believe we can empower people to improve and change their diet, lifestyle and health. TREATING MAJOR NEEDS Gelesis is a biotechnology company developing a novel category of therapies for GI-related chronic diseases. Our superabsorbent hydrogels mimic some of the properties of raw vegetables. They are conveniently administered in capsules and act locally in the stomach and intestines. They increase the volume and firmness of the foods we eat while reducing the caloric density of meals. Our portfolio includes an FDA cleared product to aid in weight management, as well as potential therapies in development for Type 2 Diabetes, Non-alcoholic Fatty Liver Disease (NAFLD)/Non-alcoholic Steatohepatitis (NASH), and Functional Constipation. INTRODUCING PLENITY® Packaging shown for representation purposes only. Actual packaging design may vary. Plenity is not yet available for sale. HOW IT WORKS PLENITY® is indicated to aid in weight management in adults who are overweight or obese and have a body mass index (BMI) of 25 to 40 kg/m² when combined with diet and exercise. In clinical trials, side effects with PLENITY were similar to placebo (sugar pill). The most common side effects were fullness, bloating, flatulence, and/or abdominal pain. Instructions for use DISCOVER PLENITY® CLINICAL DATA “We are thrilled to be able to bring this new approach to the millions of people looking for a safe, validated and convenient approach to manage their weight without surgery or stimulants.” A NOVEL HYDROGEL TECHNOLOGY PLATFORM Our hydrogel is designed to mimic some of the effects of eating raw vegetables. LEARN MORE The proprietary Gelesis platform is the first and only superabsorbent hydrogel made exclusively from naturally-derived building blocks. © 2021 Gelesis – All rights reserved Terms and conditions Privacy Policy E.U. GDPR – English | Italian Social Media Community Guidelines Patent Notice Contact

HOME MAJOR NEEDS SCIENCE PRODUCTS PEOPLE PRESS INVESTORS CAREERS REGION INVESTOR INFORMATION We are a biotherapeutics company built for consumer engagement. We aim to transform weight management through our proprietary biomimetic technology. PRESS RELEASE INVESTOR PRESENTATION INVESTOR CALL “We are committed to our mission of empowering people to improve and change their diet, lifestyle, and health and to build on the exciting momentum of our beta launch.” Yishai Zohar, Founder and CEO © 2021 Gelesis – All rights reserved Terms and conditions Privacy Policy E.U. GDPR – English | Italian Social Media Community Guidelines Patent Notice Contact

HOME MAJOR NEEDS SCIENCE PRODUCTS PEOPLE PRESS INVESTORS CAREERS REGION CAREERS AT GELESIS There are no open positions a Gelesis right now. Please come back later. Contact us to learn more about career opportunities careers@gelesis.com LEARN MORE ABOUT OUR ONGOING RESEARCH GELESIS PIPELINE © 2021 Gelesis – All rights reserved Terms and conditions Privacy Policy E.U. GDPR – English | Italian Social Media Community Guidelines Patent Notice Contact