About Products & Pipeline Partnering Investors & News Blog The Story Of Mytesi 1234567 The annualized dollar amounts appearing on this timeline are estimates, and the provided figures represent estimated expenses incurred by multiple entities including Jaguar Health, Inc., Napo Pharmaceuticals, Inc., predecessor entities, and partner organizations. Mytesi’s Ethnobotanical Origins The term ethnobotanical refers to the use of plants by indigenous people in the course of their everyday lives, including the use of plants for medicine. Crofelemer, the active pharmaceutical ingredient in Mytesi, is derived from the Amazonian tree species, Croton lechleri, and has a rich history of medicinal use by indigenous peoples in the Western Amazon rainforests of South America. The tree produces a blood red latex from which crofelemer is isolated and purified. The tree is commonly called “Sangre de drago” in Spanish, which translates to “Dragon’s blood” in English. Croton lechleri tree The Croton lechleri tree is one of the most widely used plant-derived medicines in the western hemisphere. Red latex from Croton lechleri trees continues to be part of rural and urban traditional medicine in multiple countries including Peru, Colombia, Ecuador, and Bolivia. Indigenous people utilize the red latex to treat a variety of medical conditions. Its most common uses are taking small quantities of the latex orally to treat diarrhea, stomach ulcers, coughs, and flu. The red latex is also applied topically as a wound healing agent for cuts and open sores, and for healing the gums after tooth extractions. It has been and continues to be used to treat humans as well as dogs and livestock. Crofelemer is extracted and purified from the red latex of Croton lechleri, shown here as it exudes from the cut bark of the tree Because of its widespread medicinal use, there has been extensive research conducted on the chemistry and pharmacology of this red latex. Mytesi is the result of decades of research that began with the expertise of traditional healers of the Amazon Rainforest. Maria Davila Lopez, an Awajun indigenous mother, collecting latex from a Croton lechleri tree that she planted in her agroforestry “living pharmacy” next her house, to treat a wound on her son’s head The Croton lechleri tree is rapidly growing and abundant in multiple countries. Jaguar and its predecessor companies always focus on the long-term sustainable management of the tree as part of our commitment to helping local communities both conserve their natural resources while also earning income for the basic needs of their families, such as food, clothing, health care and education. Jaguar employees have been collaborating with local communities, business partners and scientists for the past 30 years to make certain that the development and sale of this product provides benefit to local communities. Large numbers of these trees have been planted, and re-planted upon harvesting, across Peru in collaboration with communities and small local businesses. Traditional Medicine & Public Health At Jaguar and Napo, we recognize the unique and powerful knowledge traditional peoples have about plants, ecosystems, interrelationships, and healing compounds. This knowledge has led to drug products that have changed the world, such as quinine did for malaria. Links to learn more: The Journal of Alternative and Complementary Medicine – Volume 10, Number 6, 2004: Phytomedicine, Public Health, and Traditional Healers The Journal of Alternative and Complementary Medicine – Volume 9, Number 6, 2003: Biocultural Diversity, Phytomedicines, and Tropical Rainforests About Mytesi® Mytesi (crofelemer) is an antidiarrheal indicated for the symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy (ART). Mytesi is not indicated for the treatment of infectious diarrhea. Rule out infectious etiologies of diarrhea before starting Mytesi. If infectious etiologies are not considered, there is a risk that patients with infectious etiologies will not receive the appropriate therapy and their disease may worsen. In clinical studies, the most common adverse reactions occurring at a rate greater than placebo were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough (3.5%), flatulence (3.1%), and increased bilirubin (3.1%). See full Prescribing Information at Mytesi.com. Crofelemer, the active ingredient in Mytesi, is a botanical (plant-based) drug extracted and purified from the red bark sap of the medicinal Croton lechleri tree in the Amazon Rainforest. Napo has established a sustainable harvesting program for crofelemer to ensure a high degree of quality and ecological integrity. © Copyright 2020 Jaguar Health Contact Us | Careers | Legal Notice | Privacy Policy | Social Media Policy | Website Accessibility Feedback Email | Web Accessibility Feedback Form | Admin |