ORBERA® OVERSTITCH™ INVESTORS CONTACT US COMPANY Investor Relations Corporate Presentation Annual Report Quarterly Report Current Report NASDAQ: APEN $8.40 +0.17 +2.07% 20 Minute Delay Press Releases SEC Filings Financial Information Events & Presentations Governance Analyst Coverage Investor Kit Email Alerts Overview Apollo Endosurgery, Inc. is a medical technology company focused on less invasive therapies to treat various gastrointestinal conditions, ranging from gastrointestinal defect repairs to the interventional treatment of obesity. Apollo’s device-based therapies are an alternative to invasive surgical procedures, thus lowering complication rates and reducing total healthcare costs. Apollo’s products are offered in over 70 countries today and include the OverStitch™ Endoscopic Suturing System, the OverStitch Sx™ Endoscopic Suturing System, and the ORBERA® Intragastric Balloon. Recent News Corporate Presentation Home Patient Labeling and DFUs Patent Notices Terms of Sale Website Terms of Use Privacy Policy MKT-01085-00R03 © 2021 Apollo Endosurgery, Inc.

COVID-19 Update for Current Intragastric Balloon Patients ORBERA® OVERSTITCH™ X-TACK™ INVESTORS CONTACT US COMPANY Compliance Please see below the following links for our compliance documents. California Compliance Disclosure Apollo Endosurgery Code of Business Conduct and Ethics Apollo Ethics Helpline Home Directions for Use Patent Notices Terms of Sale Website Terms of Use Privacy Policy MKT-01085-00R06 © 2021 Apollo Endosurgery, Inc.

COVID-19 Update for Current Intragastric Balloon Patients ORBERA® OVERSTITCH™ X-TACK™ INVESTORS CONTACT US COMPANY Patent Notices Please see the following table for U.S. Patents covering Apollo Endosurgery Products. The absence of a product name from this list or U.S. Patent number as associated with any listed product does not constitute a waiver of Apollo Endosurgery’s patent, trademark, or other intellectual property rights concerning that product. PRODUCT PATENT NO. OverStitch® Endoscopic Suturing System U.S. 6,719,763 U.S. 6,755,843 U.S. 6,988,987 U.S. 8,021,376 U.S. 8,287,556 U.S. 8,540,735 U.S. 8,679,136 U.S. 9,089,325 U.S. 9,198,562 Orbera® Intragastric Balloon System U.S. 7,749,254 X-Tack™ Endoscopic HeliX Tacking System Patent Pending Revised: 2/2021 Home Directions for Use Patent Notices Terms of Sale Website Terms of Use Privacy Policy MKT-01085-00R06 © 2021 Apollo Endosurgery, Inc.