Home About Us Pipeline Expanded Access Investors & Media Contact Us BPDCN HomePipelineClinical Trials ELZONRIS™ (TAGRAXOFUSP) CLINICAL TRIALS ELZONRIS is a novel targeted therapy directed to the IL-3R (CD123). ELZONRIS comprises human IL-3 recombinantly fused to a truncated diphtheria toxin (DT) payload engineered such that IL-3 replaces the native DT receptor-binding domain. The IL-3 domain of ELZONRIS directs the cytotoxic DT payload to cells expressing CD123. Upon internalization, ELZONRIS irreversibly inhibits protein synthesis and induces apoptosis of the target cell. Given this novel mechanism of action, there is a potential to develop ELZONRIS as both a single agent and in combination with other therapies. ELZONRIS was approved by the Food and Drug Administration (FDA) on December 21, 2018, for the treatment of adult and pediatric patients, 2 years and older, with blastic plasmacytoid dendritic cell neoplasm (BPDCN). In January 2019, a marketing authorization application (MAA) for ELZONRIS for the treatment of patients with BPDCN was submitted to the EMA. Previously, the EMA granted the MAA accelerated assessment status. ELZONRIS is also being evaluated in clinical trials in additional indications including chronic myelomonocytic leukemia (CMML), myelofibrosis (MF), and other indications. For more information on current ELZONRIS clinical trials, click the links below or visit clinicaltrials.gov. INDICATION STATUS LINK Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Open BPDCN Trial Acute Myeloid Leukemia (AML), Relapsed/Refractory Open AML Trial Chronic Myelomonocytic Leukemia (CMML) Open Advanced, High-Risk MPN Myelofibrosis (MF) Open Advanced, High-Risk MPN SL-701 CLINICAL TRIALS SL-701 is an immunotherapy designed to activate the immune system to attack tumors. A multicenter clinical trial with SL-701 in combination with an immunostimulant and bevacizumab has completed enrollment of adult patients with glioblastoma multiforme (GBM) in first recurrence. Discussions around next steps to further unlock potential value from the program are ongoing. INDICATION STATUS LINK Adult Glioblastoma Multiforme (GBM), in First Recurrence Completed GBM Trial SL-801 CLINICAL TRIALS SL-801 is a novel, oral, small-molecule reversible inhibitor of exportin-1 (XPO1), a key nuclear transport protein. XPO1 is overexpressed by many cancers, leading to mislocalization of key tumor suppressors and growth-regulatory proteins in the cytoplasm. A Phase 1 trial is ongoing, and currently enrolling patients with advanced solid tumors. INDICATION STATUS LINK Advanced Solid Tumors Open SL-801 Advanced Solid Tumors About Us Management Business Development Pipeline Clinical Trials Scientific Presentations Investors & Media News & Events Contact Us BPDCN © 2021 – Stemline Therapeutics, Inc. All rights reserved | Privacy & Terms of Use | CCPA Policy | Cookie Policy Stemline Therapeutics is a society of the Menarini Group