PELAGO KNOWLEDGE CENTER Search Or choose topic Biomarker discovery Compound potency ranking Degraders Hit confirmation Lead optimisation Mechanism of action (MoA) Mode of action Phenotypic deconvolution Selectivity profiling Target deconvolution Target Engagement Target validation Welcome to Pelago Knowledge Center We hope you will enjoy our collection of resources, information and facts. A majority of drug candidates fail in clinical trials. Many of them fail in late proof-of-concept studies due to a lack of efficacy, which results in increased costs and lost time. This waste of time and resources can be avoided by applying target engagement studies with high accuracy and predictive value early and continuously in the drug discovery value chain. Select a topic to begin. Compound Evaluation and Potency Ranking Including CETSA® in your assay cascade and using the EC50 data for potency ranking within your chemical series facilitates a relevant compound design yielding compounds with higher chance of therapeutic effect. READ THE FULL ARTICLE Selectivity In drug discovery, selective binding of the compound to the right target is important for the drug to be both effective and safe. To achieve this, the drug must be present at the site of action and occupy the intended target with high specificity. READ THE FULL ARTICLE Mechanism of Action for Degraders Targeted protein degradation is a novel modality with the potential to tackle therapeutically interesting proteins beyond the limitations of current existing approaches. In this area, CETSA® is a powerful technology which can be applied for investigating the degradation target READ THE FULL ARTICLE Target Engagement For a drug to be effective according to the target hypothesis, it must selectively bind to the intended target protein to elicit its effect. Target engagement (TE) is defined as the interaction of ligands with their molecular targets. Assessment of a compound’s TE is essential in the discovery and development of new therapies. READ THE FULL ARTICLE Library Screening CETSA® can determine cellular target engagement in physiologically relevant settings of the native, full-length protein and can potentially unlock novel chemical space. CETSA® library screening in intact cells gives direct confirmation on target engagement of your library compounds in physiological conditions from the onset. READ THE FULL ARTICLE Hit Confirmation As a cellular target engagement assay that determines the level of interaction between a ligand and a target protein of interest in a physiologically relevant setting, CETSA® is perfectly suited for hit confirmation. READ THE FULL ARTICLE BOOK A MEETING Pelago Bioscience AB Banvaktsvägen 20 171 48 Solna Sweden Contact us Privacy Policy We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept”, you consent to the use of ALL the cookies. Pelago Cookies Policy Cookie settings Accept