Home Drug Product Development & Manufacturing Services Drug Product Formulation Development You are here Contact us Solid dispersions Amorphous solid dispersions increase DS solubility through elimination of the impact of crystal lattice energy on the dissolution process. The physical stabilisation of the amorphous state of the DS is accomplished via dispersion in a polymer matrix. The identification of a polymer with sufficient solid-state miscibility with the DS is key to preventing recrystallisation and to ensuring consistent performance over time. We identify suitable carrier polymers via a combined approach of precipitation assays and solvent evaporation trials, both conducted at milligram scale. Formulation concepts with adequate performance and physical stability are subsequently scaled-up and GMP-produced via either spray-drying or bead-layering. Back to drug product development & manufacturing Services Drug Product Formulation Development Lipid based formulations Nanosuspensions Solid Dispersions Drug Product Analytical Development & QC Drug Product Stability Studies Drug Product Manufacturing Highlights Capabilities Contact us today Get in touch with us to discuss your next project Register for our newsletter Do you wish to remain up to date with drug development insights, industry trends & Ardena news? Click here to register Services Drug Substance Solid State Research Drug Product Clinical Logistics Bioanalysis Dossier Development Nanomedicine Navigation About Us Careers News & Insights Contact Legal entities General Terms and Conditions Contact details Ardena Kleimoer 4 B-9030 Mariakerke Belgium Telephone +32 9 267 65 00 Fax: +32 9 267 65 10 © Ardena Holding NV 2021 LinkedIn Sitemap Privacy Policy Ardena respects your right to privacy Your ability to make informed choices about the use of your information is important to us. This cookie statement details which cookies we or other parties can place on your device and how we and other parties use this information within Ardena. If you have any comments or questions about this cookie statement or the collection and use of your personal data, please contact our data protection GDPR@ardena.com More info. Set preferences Accept cookies