Patent Document ID: 10134131
Application ID: 15433027

Base Claim:
1. A method, comprising: receiving, by a computing device, a target image of a target biological cell having a target phenotype; obtaining, by the computing device, a semantic embedding associated with the target image, wherein the semantic embedding associated with the target image is generated using a machine-learned, deep metric network model; obtaining, by the computing device for each of a plurality of candidate images of candidate biological cells each having a respective candidate phenotype, a semantic embedding associated with the respective candidate image, wherein the semantic embedding associated with the respective candidate image is generated using the machine-learned, deep metric network model; determining, by the computing device, a similarity score for each candidate image, wherein determining the similarity score for a respective candidate image comprises computing, by the computing device, a vector distance in a multi-dimensional space described by the semantic embeddings between the respective candidate image and the target image, and wherein the similarity score for each candidate image represents a degree of similarity between the target phenotype and the respective candidate phenotype; determining, by the computing device, a threshold similarity score; and determining, by the computing device, those candidate images having similarity scores that satisfy the threshold similarity score, wherein the target phenotype is a healthy phenotype, wherein the candidate images having similarity scores that satisfy the threshold similarity score have respective candidate phenotypes corresponding to the healthy phenotype, and wherein those candidate images having similarity scores that do not satisfy the threshold similarity score have respective candidate phenotypes corresponding to an unhealthy phenotype.

---

Claim 6:
6. The method of claim 1 , further comprising: receiving, by the computing device, a second target image of a second target biological cell having a second target phenotype; obtaining, by the computing device, a semantic embedding associated with the second target image, wherein the semantic embedding associated with the second target image is generated using the machine-learned, deep metric network model; determining, by the computing device, a second similarity score for each candidate image, wherein determining the second similarity score for a respective candidate image comprises computing, by the computing device, a vector distance in the multi-dimensional space described by the semantic embeddings between the respective candidate image and the second target image, and wherein the second similarity score for each candidate image represents a degree of similarity between the second target phenotype and the respective candidate phenotype; determining, by the computing device, a second threshold similarity score; and determining, by the computing device, those candidate images having second similarity scores that satisfy the second threshold similarity score, wherein the second target phenotype is a second unhealthy phenotype, wherein the candidate images having second similarity scores that satisfy the second threshold similarity score have respective candidate phenotypes corresponding to the second unhealthy phenotype, and wherein those candidate images having second similarity scores that do not satisfy the second threshold similarity score have respective candidate phenotypes that do not correspond to the second unhealthy phenotype.