Patent Document ID: 20170144970
Application ID: 15115187
Patent Flag: 0

Claim One:
1. An isolated compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 and R 2 are each independently selected from H, C 1 -C 6 alkyl, or CH 2 OR′; where R′═H or C 1 -C 6 alkyl; R 3 , R 4 , R 5 , and R 6 are each independently selected from H, C 1 -C 6 alkyl, OH, OCH 3 , OCH(CH 3 ) 2 , OCH 2 CH(CH 3 ) 2 , OC(CH 3 ) 3 , O(C 1 -C 6 alkyl), OCF 3 , OCH 2 CH 2 OH, O(C 1 -C 6 alkyl)OH, O(C 1 -C 6 haloalkyl), F, Cl, Br, I, CF 3 , CN, NO 2 , NH 2 , C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1-6 alkoxy C 1-6 alkyl, aryl, heteroaryl, C 3-7 cycloalkyl, heterocycloalkyl, alkylaryl, heteroaryl, CO 2 R′, C(O)R′, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , NH(C 3-7 cycloalkyl), NHC(O)(C 1-4 alkyl), CONR′ 2 , NC(O)R′, NS(O) n R′, S(O) n NR′ 2 , S(O) n R′, C(O)O(C 1-4 alkyl), OC(O)N(R′) 2 , C(O) (C 1-4 alkyl), and C(O)NH(C 1-4 alkyl); where n=0, 1, or 2; R′ are each independently H, CH 3 , CH 2 CH 3 , C 3 -C 6 alkyl, C 1 -C 6 haloalkyl; or optionally substituted aryl, alkylaryl, piperazin-1-yl, piperidin-1-yl, morpholinyl, heterocycloalkyl, heteroaryl, C 1-6 alkoxy, NH(C 1-4 alkyl), or NH(C 1-4 alkyl) 2 , wherein optionally substituted group is selected from C 1 -C 6 alkyl or C 2 -C 7 acyl; or R 3 and R 4 , together with the C atom to which they are attached form a form a 4-, 5-, 6-7- or 8-membered cycloalkyl, aryl, heteroaryl, or heterocycloalkyl that is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, and heterocycloalkyl and R 3 and R 4 , or R 4 and R 5 , are each independently selected from a bond, C, N, S, and O; or R 3 and R 4 are linked together to form a —O—C 1-2 methylene-O— group; or R 4 and R 5 , together with the C atom to which they are attached form a form a 4-, 5-, 6-7- or 8-membered cycloalkyl, aryl, heteroaryl, or heterocycloalkyl that is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, and heterocycloalkyl and R 3 and R 4 , or R 4 and R 5 , are each independently selected from a bond, C, N, S, and O; or R 4 and R 5 are linked together to form a —O—C 1-2 methylene-O— group; R 7 , R 8 , R 9 , R 10 , and R 11 are each independently selected from H, C 1 -C 6 alkyl, OH, OCH 3 , OCH(CH 3 ) 2 , OCH 2 CH(CH 3 ) 2 , OC(CH 3 ) 3 , O(C 1 -C 6 alkyl), OCF 3 , OCH 2 CH 2 OH, O(C 1 -C 6 alkyl)OH, O(C 1 -C 6 haloalkyl), O(CO)R′, F, Cl, Br, I, CF 3 , CN, NO 2 , NH 2 , C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, C 1-6 alkoxy C 1-6 alkyl, aryl, heteroaryl, C 3-7 cycloalkyl, heterocycloalkyl, alkylaryl, heteroaryl, CO 2 R′, C(O)R′, NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , NH(C 3-7 cycloalkyl), NHC(O)(C 1-4 alkyl), CONR′ 2 , NC(O)R′, NS(O) n R′, S(O) n NR′ 2 , S(O) n R′, C(O)O(C 1-4 alkyl), OC(O)N(R′) 2 , C(O) (C 1-4 alkyl), and C(O)NH(C 1-4 alkyl); where n=0, 1, or 2; R′ are each independently H, CH 3 , CH 2 CH 3 , C 3 -C 6 alkyl, C 1 -C 6 haloalkyl, aryl, alkylaryl, piperazin-1-yl, piperidin-1-yl, morpholinyl, heterocycloalkyl, heteroaryl, C 1-6 alkoxy, NH(C 1-4 alkyl), or NH(C 1-4 alkyl) 2 ; or R 7 and R 8 , together with the N or C atoms to which they are attached form a form a 4-, 5-, 6-7- or 8-membered cycloalkyl, aryl, heterocycloalkyl or heteroaryl group that is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, and heterocycloalkyl and R 9 and R 10 are each independently selected from a bond, C, N, S, and O; or R 7 and R 8 are linked together to form a —O—C 1-2 methylene-O— group; or R 8 and R 9 , together with the N or C atoms to which they are attached form a form a 4-, 5-, 6-7- or 8-membered cycloalkyl, aryl, heterocycloalkyl or heteroaryl group that is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, and heterocycloalkyl and R 9 and R 10 are each independently selected from a bond, C, N, S, and O; or R 8 and R 9 are linked together to form a —O—C 1-2 methylene-O— group; wherein each of the O, C 1-6 alkyl, C 1-6 haloalkyl, heteroaryl, aryl, heteroaryl, heterocycloalkyl, and cycloalkyl is optionally independently substituted with 1, 2, 3, 4, or 5 substituents independently selected from OH, amino, halo, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl; with the proviso that the following compounds, or pharmaceutically acceptable salts thereof, are excluded: