Patent Document ID: 9107868
Application ID: 13569510
Patent Flag: 1

Claim One:
1. A method of treating chronic neuropathic pain in a subject, comprising administering, to a sensory neuron in a dorsal root ganglion of the subject, an effective amount of an agent having formula I: wherein n is 1, 2 or 3; Z is N or CH; wherein X represents one of the following functional groups: wherein Y represents one of the following functional groups: wherein A represents aryl or heteroaryl groups un-substituted or substituted by one or more lower-alkyl, lower-alkoxy, hydroxy, alkoxy, amino, alkylamino or halogen groups; wherein R is hydrogen, lower-alkyl, or amidino; wherein R1, R2, R4, R5 is independently hydrogen, hydroxyl, lower-alkoxy, amino, or halogen; and wherein R3 is alkyl, aryl, heteroaryl, alkoxy, aryloxy, or a group selected from the following: wherein R6-R10 are independently hydrogen, hydroxy, lower-alkyl, lower-alkoxy, halogen, trifluoromethyl, carboxy, alkoxycarbonyl, amino, alkylamino, alkylcarbonylamino, alkylsulfonylamino, and tetrazole, so that neuropathic pain in the subject is reduced.