Patent Document ID: 20130237545
Application ID: 13885569
Patent Flag: 0

Claim One:
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R′ is —COOH, —C(O)NR 1 R 2 , or a 5-membered heterocyclic or heteroaryl ring having 1-3 heteroatoms selected from N, NH, O, SO, and SO 2 ; wherein the 5-membered heterocyclic or heteroaryl ring has 0-3 substituents selected independently from J; R 1 and R 2 are independently selected from: H—, (C1-C12)-aliphatic-, (C3-C10)-cycloalkyl-, (C3-C10)-cycloalkenyl-, (C6-C10)-aryl-, (C5-C10)-heteroaryl-, and (C3-C10)-heterocyclo-; or R 1 and R 2 may be taken together with the nitrogen atom to which they are attached to form a 3- to 10-membered aromatic or non-aromatic ring having 0-3 substituents independently selected from J, and having 0-3 additional heteroatoms independently selected from N, O, S, SO, or SO 2 ; wherein each of R 1 and R 2 is independently substituted at each substitutable position with 0-3 substituents independently selected from J; R is H, halogen or (C1-C12)-aliphatic-, wherein said (C1-C12)-aliphatic group is substituted with 0-3 substituents independently selected from J; A and B are each independently selected from: (C6-C10)-aryl-, (C5-C10)-heteroaryl-, and (C3-C10)-heterocyclo-; wherein A and B are each independently substituted with 0-5 substituents independently selected from J; each J is independently selected from: halogen, —OR 3 , —NO 2 , —CN, —CF 3 , —OCF 3 , —R 3 , oxo, thioxo, 1,2-methylenedioxy, 1,2-ethylenedioxy, ═N(R 3 ), ═N(OR 3 ), —N(R 3 ) 2 , —SR 3 , —SOR 3 , —SO 2 R 3 , —SO 2 N(R 3 ) 2 , —SO 3 R 3 , —C(O)R 3 , —C(O)C(O)R 3 , —C(O)CH 2 C(O)R 3 , —C(S)R 3 , —C(S)OR 3 , —C(O)OR 3 , —C(O)C(O)OR 3 , —C(O)C(O)N(R 3 ) 2 , —OC(O)R 3 , —C(O)N(R 3 ) 2 , —OC(O)N(R 3 ) 2 , —C(S)N(R 3 ) 2 , —(CH 2 ) 0-2 NHC(O)R 3 , —N(R 3 )N(R 3 )COR 3 , —N(R 3 )N(R 3 )C(O)OR 3 , —N(R 3 )N(R 3 )CON(R 3 ) 2 , —N(R 3 )SO 2 R 3 , —N(R 3 )SO 2 N(R 3 ) 2 , —N(R 3 )C(O)OR 3 , —N(R 3 )C(O)R 3 , —N(R 3 )C(S)R 3 , —N(R 3 )C(O)N(R 3 ) 2 , —N(R 3 )C(S)N(R 3 ) 2 , —N(COR 3 )COR 3 , —N(OR 3 )R 3 , —C(═NH)N(R 3 ) 2 , —C(O)N(OR 3 )R 3 , —C(═NOR 3 )R 3 , —OP(O)(OR 3 ) 2 , —P(O)(R 3 ) 2 , —P(O)(OR 3 ) 2 , and —P(O)(H)(OR 3 ); each R 3 is independently selected from: H—, (C1-C12)-aliphatic-, (C3-C10)-cycloalkyl-, (C3-C10)-cycloalkenyl-, [(C3-C10)-cycloalkyl]-(C1-C12)-aliphatic-, [(C3-C10)-cycloalkenyl]-(C1-C12)-aliphatic-, (C6-C10)-aryl-, (C6-C10)-aryl-(C1-C12)aliphatic-, (C3-C10)-heterocyclyl-, (C6-C10)-heterocyclyl-(C1-C12)aliphatic-, (C5-C10)-heteroaryl-, and (C5-C10)-heteroaryl-(C1-C12)-aliphatic-; or two R 3 groups bound to the same atom may be taken together with the atom to which they are bound to form a 3- to 10-membered aromatic or non-aromatic ring having 1-3 heteroatoms independently selected from N, O, S, SO, and SO 2 , wherein said ring is optionally fused to a (C6-C10)aryl, (C5-C10)heteroaryl, (C3-C10)cycloalkyl, or a (C3-C10)heterocyclyl; provided that said compound of formula I is not: