Patent Document ID: 10143187
Application ID: 15923928
Patent Flag: 1

Claim One:
1. A transgenic rodent that expresses a chimeric transferrin receptor (TfR) polypeptide capable of mediating blood-brain barrier transport, wherein: (i) the transgenic rodent comprises a nucleic acid encoding the chimeric TfR polypeptide in its genome, the nucleic acid comprising a nucleic acid sequence encoding an apical domain of a primate TfR polypeptide that replaces a nucleic acid sequence encoding the apical domain of the TfR polypeptide endogenous to the transgenic rodent, (ii) the chimeric TfR polypeptide comprises a transferrin binding site endogenous to the transgenic rodent, (iii) the chimeric TfR polypeptide is expressed in the brain of the transgenic rodent, and (iv) the transgenic rodent is a mouse or rat.