Patent Document ID: 20110216313
Application ID: 13037851
Patent Flag: 0

Claim One:
1. A method for determining active drug concentration in pharmaceutical tablets by using near infrared spectroscopy and supervised principal component analysis, said method comprising the steps of: a. designing a plurality of calibration samples; b. producing data matrix X 1 (and X 2 , X 3. .. X n , if necessary) by performing spectral pretreatment of the acquired NIR spectra and selecting a wavelength range/region; c. decomposing matrix X 1 (or X 2 , X 3 ,. .. X n ) by PCA to obtain loading matrix P 1 (or P 1 , P 2 ,. .. P n ) and score matrix T 1 (or T 2 , T 3 ,. .. T n ); d. determining the correlation between PCA scores and nominal drug concentration. e. examining orthogonality of the scores of desired latent variable in the two-dimensional PC space; f. producing prediction matrix X p by combining spectra of calibration and unknown samples; g. calculating drug content for unknown samples;