Patent Document ID: 9139643
Application ID: 13225148
Patent Flag: 1

Claim One:
1. A method for treating Alzheimer's disease or other tauopathy in a subject, said method comprising: administering to said subject an isolated antibody or binding portion thereof that is capable of specifically binding to a misfolded and/or aggregate form of Tau protein and does not bind to normal Tau protein, wherein said antibody binds an epitope that is present within amino acid residues 379-408 (SEQ ID NO:2) of said misfolded and/or aggregate form of Tau protein and is capable of specifically binding to a polypeptide fragment of Tau protein consisting of Tau 379-408 (SEQ ID NO:2); wherein such antibody was produced by immunization with a polypeptide fragment of Tau consisting of Tau 379-408 (SEQ ID NO:2); and wherein said administered antibody or binding portion thereof binds to a misfolded and/or aggregate form of Tau protein of said subject, and is provided to said subject at a therapeutically-effective dose effective to treat said Alzheimer's disease or said other tauopathy.