Patent Document ID: 8071314
Application ID: 10321704
Patent Flag: 1

Claim One:
1. A method for identifying an agent that interacts with an immune related gene or gene product expressed in nervous tissue selected from the group consisting of Gp49, PIR, PIRA, PIRB, LIR, NKR-P1, NKp46, Digr1, ILT, MIR, KIR, class I MHC molecules, or fragments thereof, or expression products thereof, comprising contacting a candidate agent with the immune related gene, an allele of fragment thereof, or expression product thereof; quantitatively detecting an interaction between said immune related gene an allele of fragment thereof, or expression product thereof and the candidate agent, and separately contacting said candidate agent with neurons expressing said immune related gene in vitro or in vivo, and detecting an alteration in plasticity or activity-dependent remodeling in said neurons.