Patent Document ID: 8377963
Application ID: 13570938
Patent Flag: 1

Claim One:
1. A method for treating a disease or condition by the inhibition of IRAP activity is implicated, the method comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): wherein A is aryl, heteroaryl carbocyclyl or heterocyclyl, each of which may be optionally substituted, when R 1 is NHCOR 8 ; or quinolinyl, isoquinolinyl, cinnolinyl, quinazolinyl, quinoxalinyl, 1,8-naphthyridyl, phthalazinyl or pteridinyl, each of which may be optionally substituted, when R 1 is NR 7 R 8 , NHCOR 8 , N(COR 8 ) 2 , N(COR 7 )(COR 8 ), N═CHOR 8 or N═CHR 8 ; X is O, NR′ or S, wherein R′ is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted acyl, optionally substituted heteroaryl, optionally substituted carbocyclyl or optionally substituted heterocyclyl; R 7 and R 8 are independently selected from hydrogen, optionally substituted alkyl, optionally substituted aryl, or R 7 and R 8 , together with the nitrogen atom to which they are attached form a 3-8-membered ring which may be optionally substituted; R 2 is CN, CO 2 R 9 , C(O)O(O)R 9 , C(O)R 9 or C(O)NR 9 R 10 wherein R 9 and R 10 are independently selected from alkyl, alkenyl, alkynyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, each of which may be optionally substituted, and hydrogen; or R 9 and R 10 , together with the nitrogen atom to which they are attached, form a 3-8-membered ring which may be optionally substituted; R 3 -R 6 are independently selected from hydrogen, halo, nitro, cyano alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, alkynyloxy, aryloxy, heteroaryloxy, heterocyclyloxy, amino, acyl, acyloxy, carboxy, carboxyester, methylenedioxy, amido, thio, alkylthio, alkenylthio, alkynylthio, arylthio, heteroarylthio, heterocyclylthio, carbocyclylthio, acylthio and azido, each of which may be optionally substituted where appropriate, or any two adjacent R 3 -R 6 , together with the atoms to which they are attached, form a 3-8-membered ring which may be optionally substituted; and Y is hydrogen or C 1-10 alkyl, or a pharmaceutically acceptable salt or solvate thereof.