Patent Document ID: 8577620
Application ID: 13110265
Patent Flag: 1

Claim One:
1. A method for identifying a subject whose host-inflammatory responses to a systemic inflammatory condition are matched to the mechanism of action of a therapeutic agent for the treatment of the subject comprising: (a) obtaining one or more baseline parameters of a subject with a systemic inflammatory condition, wherein said baseline parameters comprise one or more demographic variables, physiologic variables, or results of hospital laboratory tests; (b) generating, on a computer, from the baseline parameters, a systemic mediator-associated response test (SMART) profile for the subject; (c) using statistical tests to compare the SMART profile of the subject with one or more control SMART profiles comprising independent variables for subjects who have responded positively to a therapeutic agent with a predetermined mechanism of action; (d) identifying whether the SMART profile of the subject has independent variables of the control SMART profile for the therapeutic agent with a predetermined mechanism of action; (e) selecting the therapeutic agent with the predetermined mechanism of action and treating the subject.