Patent Document ID: 7514257
Application ID: 10669861
Patent Flag: 1

Claim One:
1. An isolated transcription factor that comprises a first, second and third zinc finger domain in this order, wherein presence of the transcription factor in a vertebrate cell can alter the differentiation state of the cell, the transcription factor further comprises an activation domain, and the DNA contacting residues of the first, second, and third domains are as shown in reference sequence SEQ ID NO: 2 as follows: (i) glutamine at position −1 of the first zinc finger domain; serine at position 2 of the first zinc finger domain; asparagine at position 3 of the first zinc finger domain; and arginine at position 6 of the first zinc finger domain; (ii) glutamine at position −1 of the second zinc finger domain; serine at position 2 of the second zinc finger domain; asparagine at position 3 of the second zinc finger domain; and lysine at position 6 of the second zinc finger domain; and (iii) cysteine at position −1 of the third zinc finger domain; serine at position 2 of the third zinc finger domain; asparagine at position 3 of the third zinc finger domain; and arginine at position 6 of the third zinc finger domain.