Patent Document ID: 5516772
Application ID: 08307530
Patent Flag: 1

Claim One:
1. A method for enhancing a neurotrophin-induced activity of a neurotrophin responsive cell, said method comprising contacting said cell with a K-252a derivative of the formula: ##STR11## wherein: a) Z.sup.1 and Z.sup.2 together represent O; each R.sup.1, R.sup.2, R.sup.5, and R.sup.6 independently is H, F, Cl, Br, I, NO.sub.2, CN, alkyl of 1-6 carbons or NR.sup.13 R.sup.14 independently is H or n-alkyl of 1-6 carbons; Y is H, OH, NH.sub.2, n-alkyl of 1-6 carbons, CHO, OCONH.sub.2 benzyl, O-n-alkyl of 1-6 carbons, (CH.sub.2).sub.n OH or (CH.sub.2).sub.n NH.sub.2 where n is an integer of 1-6; then either 1) R is OH, OCONH.sub.2, or O-n-alkyl of 1-6 carbons; and X is CH.sub.2 OH, CH.sub.2 NH.sub.2, (or an acid salt thereof;) CH.sub.2 O-n-alkyl of 2-7 carbons CO.sub.2 R.sup.7 where R.sup.7 is H or alkyl of 1-6 carbons, CONHOR.sup.8, CONH(CH.sub.2).sub.n OR.sup.8 where n is an integer of 1-6 and R.sup.8 is H or an acyl derivative group, or CONHR.sup.9 where R.sup.9 is alkyl of 1-3 carbons; or 2) R and X are combined to form a linking group of the formula --CH.sub.2 OCR.sup.10 R.sup.11 O-- where each R.sup.10 and R.sup.11 independently is H or alkyl of 1-3 carbons; or --CH.sub.2 NR.sup.12 CO.sub.2 -- where R.sup.12 is H or alkyl of 1-3 carbons; or b) Z.sup.1 is H and Z.sup.2 is OH; Y is H or CHO; R is OH; and X is CONH(CH.sub.2).sub.2 OH, CO.sub.2 CH.sub.3, or CH.sub.2 OH; and R.sup.1, R.sup.2, R.sup.5 and R.sup.6 are as defined in a); or c) Z.sup.1 and Z.sup.2 are both H and R, Y and X are as defined in b), except that X cannot be CO.sub.2 CH.sub.3 ; and when R.sup.1 is Br, X cannot be CH.sub.2 OH; and R.sup.1, R.sup.2, R.sup.5 and R.sup.6 are as defined in a); or d) Z.sup.1 is H and Z.sup.2 is SR.sup.15 where R.sup.15 is n-alkyl of 1-3 carbons; and Y, R and X are defined as in b), except that when R.sup.15 is C.sub.2 H.sub.5, X cannot be CH.sub.2 OH; and R.sup.1, R.sup.2, R.sup.5 and R.sup.6 are as defined in a).