Patent Document ID: 9139881
Application ID: 13881030
Patent Flag: 1

Claim One:
1. A method for determining that a human subject is highly susceptible to breast cancer, comprising the following steps: 1) contacting a nucleic acid sample from a human subject with a first probe consisting of SEQ ID NO: 3 and a second probe consisting of SEQ ID NO: 4 to form hybridization complexes between the first and second probes and target nucleic acids in the sample; 2) determining the quantity of the hybridization complexes; 3) detecting a decrease in the DNA copy number of a first human chromosomal region in 15q26.3 consisting of the nucleotide sequence shown in SEQ ID NO: 3, and a second human chromosomal region in 15q26.3 consisting of the nucleotide sequence shown in SEQ ID NO: 4 based on the quantity of the hybridization complexes determined in step 2); 4) comparing the decrease in DNA copy number of the two human chromosomal regions of the human subject detected in step 3) to the DNA copy number of the two human chromosomal regions in an individual without breast cancer; and 5) determining that the human subject is highly susceptible to breast cancer based on the determination of a frequency of DNA copy number of less than 1.5 of the nucleotide sequence shown in SEQ ID NO: 3, and a frequency of DNA copy number of less than 0.5 of the nucleotide sequence shown in SEQ ID NO: 4.