Patent Document ID: 8000948
Application ID: 10518103
Patent Flag: 1

Claim One:
1. A computer-implemented method for reconstructing human metabolism in a non-disease state and a disease state, said method comprising: (a) collecting metabolic data for said non-disease and disease states; (b) linking the data into metabolic pathways using a relational database; (c) ranking the metabolic pathways based on their relevance to human metabolism, wherein the ranking of the metabolic pathways comprises assigning each pathway to one of the following categories, from the most relevant to the least relevant to human metabolism: (i) a multi-step pathway wherein all of the reactions are catalyzed by known human enzymes and/or enzymes that have open reading frame (ORF) candidates in the human genome; (ii) a multi-step pathway wherein not all of the reactions are catalyzed by known human enzymes and/or enzymes that have ORF candidates in the human genome; and (iii) a single step pathway; (d) linking said ranked metabolic pathways to functional information, disease manifestations and/or high-throughput screening information; (e) identifying interconnections between the ranked metabolic pathways; and (f) reconstructing human metabolism in said non-disease and disease states on the basis of information obtained in steps (a) through (e).