Patent Document ID: 9017685
Application ID: 12580870
Patent Flag: 1

Claim One:
1. A method of inhibiting the generation of a Th-17 effector cell, said method comprising the step of: a. exposing a Th-17 effector cell precursor to an antagonist of interleukin-23 (IL-23) function thereby inhibiting the generation of the Th-17 effector cell; b. exposing a Th-17 effector cell precursor to an antagonist of transforming growth factor-beta (TGF-β) function, an antagonist of interleukin-6 (IL-6) function, an antagonist of interleukin-17 (IL-17) function or a combination of the foregoing; and c. exposing the Th-17 effector cell precursor to an effective amount of an agent that inhibits Th-17 effector cell activity.