Patent Document ID: 9717761
Application ID: 14359623
Patent Flag: 1

Claim One:
1. A method for inducing selective differentiation of oral mucosa stem cells (OMSC) into neuron-supporting glial cells, comprising: (a) obtaining oral mucosa stem cells (OMSC) from oral mucosa; (b) incubating the OMSC of (a) in a pre-differentiating medium, comprising N-2 supplement, basic fibroblast growth factor 2 (bFGF) and epidermal growth factor (EGF); and (c) after incubation of the OMSC in (b), replacing the pre-differentiation medium of (b) with a differentiating medium comprising dibutyryl cyclic adenosine monophosphate (dbcAMP), IBMX (3-Isobutyl-1-methylxanthine), neuregulin, and platelet-derived growth factor (PDGF) and incubating the OMSC from (b) in the differentiation medium to selectively differentiate OMSC into neuron-supporting glial cells secreting neurotrophic factors.