Patent Document ID: 9062125
Application ID: 12676991
Patent Flag: 1

Claim One:
1. A method of improving memory in a subject comprising administering to the subject a pharmaceutically acceptable amount of a GIP peptide analogue selected from the group consisting of: a peptide 12 to 42 amino acids in length and comprising at least 12 consecutive amino acid residues from the N-terminal end of gastric inhibitory polypeptide (SEQ ID NO:1); an analogue thereof 12 to 42 amino acids in length and comprising at least 12 consecutive amino acid residues from the N-terminal end of gastric inhibitory polypeptide (SEQ ID NO:1) with an amino acid substitution or modification consisting of acetylation at position 1; an analogue thereof 12 to 42 amino acids in length and comprising at least 12 consecutive amino acid residues from the N-terminal end of gastric inhibitory polypeptide (SEQ ID NO:1) with an amino acid substitution at position 2; an analogue thereof 12 to 42 amino acids in length and comprising at least 12 consecutive amino acid residues from the N-terminal end of gastric inhibitory polypeptide (SEQ ID NO:1) with a modification comprising the attachment of a polymer moiety of the general formula HO—(CH 2 —O—CH 2 ) n —H, in which n is an integer between 1 and about 22, to the alpha or epsilon amino groups of a lysine residue chosen from the group consisting of Lys(16), Lys(30), Lys(32), Lys(33), and Lys(37); and an analogue thereof 12 to 42 amino acids in length and comprising at least 12 consecutive amino acid residues from the N-terminal end of gastric inhibitory polypeptide (SEQ ID NO:1) with a modification by a fatty acid addition at an epsilon amino group of at least one lysine residue selected from Lys(16), Lys(30), Lys(32), Lys(33) and Lys(37).