Patent Document ID: 8232095
Application ID: 11719749
Patent Flag: 1

Claim One:
1. A method for automatic optimization of a biological sample representing a biological system, comprising: (a) providing a system comprising the biological sample, wherein the system comprises at least one stimulator, at least one sensor operable to measure at least one parameter, and a controller operably connected to the at least one sensor and the at least one stimulator; (b) measuring at least one parameter in the biological sample, wherein the controller receives a signal from the at least one sensor; and (c) providing a stimulus from the at least one stimulator to the biological sample to alter the at least one parameter measured in step (b), or at least one other parameter, or a combination thereof, within the controller by running a Gur Game algorithm that does not require an a priori model of the system, wherein the algorithm determines the stimulus given to the biological sample, and the determination is based at least in part on the at least one parameter measured by the sensor in step (b), thereby automatically optimizing the biological sample to produce a desired biological response to the stimulus, wherein the algorithm is set to direct an iterative repetition of measuring at least one parameter in the system, actuating the at least one stimulator and measuring at least one parameter modified in response to the stimulation, thereby manipulating and/or optimizing the biological system to achieve the desired biological response.