Patent Document ID: 7842666
Application ID: 10327213
Patent Flag: 1

Claim One:
1. An isolated polypeptide comprising a neuronal binding region consisting of an Ig-like domain 1 (Igd1) of a protein, wherein said protein has at least 75% sequence identity to SEQ ID NO: 2, 4 or 6 and said neuronal binding region is capable of binding said polypeptide to neuronal surfaces; the polypeptide further comprises at least one of MAG Ig-like domain 5 (Igd5) amino acid residues 432 to 488 and lacks MAG Igd5 amino acid residues 450 to 490 or 450 to 453 of SEQ ID NO: 2, 4, or 6; and whereby the ability of the polypeptide to regulate neurite outgrowth as compared to endogenous or soluble MAG is reduced or eliminated.