Patent Document ID: 20160280739
Application ID: 15180031
Patent Flag: 0

Claim One:
1. A method for the treatment of a disease or disorder presenting behavioral abnormalities associated with impairment of sensory gating function, depression or cognitive impairment, comprising administering to a patient in need thereof an effective amount of a synthetic linear peptide of the sequence: (SEQ ID NO: 3) R 1 -Xaa 1 -Gly-Xaa 2 -Xaa 3 -Xaa 4 -NHR2 wherein: Xaa 1 is selected from the group consisting of Phe, Ile, Leu, Val, Nle and analogs thereof; Xaa 2 is selected from the group consisting of Leu, Ile, Val, Nle, Phe and analogs thereof; Xaa 3 is selected from the group consisting of Arg, Lys, homo-Arg, homo-Lys, Orn and analogs of Arg; Xaa 4 is selected from the group consisting of Trp and analogs thereof; R 1 is 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-Fmoc (FMS); and R 2 is H or (CH 2 ) 0-4 CH 3 , or a pharmaceutically acceptable salt thereof, thereby treating the disease or disorder.