Patent Document ID: 4605642
Application ID: 06583092
Patent Flag: 1

Claim One:
1. A composition for lowering stressinduced secretion of ACTH, .beta.-endorphin, .beta.-lipotropin and proopiomelanocortin-related peptides in mammals comprising an effective amount of a synthetic peptide or a nontoxic addition salt thereof having the sequence: R.sub.8 -R.sub.9 -leu-R.sub.11 -R.sub.12 -R.sub.13 -leu-leu-Arg-R.sub.17 -R.sub.18 -R.sub.19 -Glu-R.sub.21 -R.sub.22 -R.sub.23 -R.sub.24 -R.sub.25 -R.sub.26 -R.sub.27 -R.sub.28 -R.sub.29 -Gln-ala-R.sub.32 -R.sub.33 -Asn-Arg-R.sub.36 -R.sub.37 -R.sub.38 -R.sub.39 -R.sub.40 R.sub.41 wherein R.sub.8 is ala, Gly, Gln, Ile, leu, Nle, Phe, Val or des-R.sub.8; R.sub.9 is Asp, Glu or des-R.sub.9; R.sub.12, R.sub.19 and R.sub.24 are selected from the group consisting of leu, Ile, ala, Asn, Gly, Val, Nle, Phe and Gln; R.sub.11 is Thr or Ser; R.sub.13 is His, Tyr or Glu; R.sub.17 is Glu, Asn or Lys; R.sub.18 is Val, Nle or Met; R.sub.21 is Met, Nva, Ile, ala, leu, Gly, Nle, Val, Phe or Gln; R.sub.22 is ala or Thr or Glu; R.sub.23 is Arg, Orn, and Har or Lys; R.sub.25 is Asp or Glu; R.sub.26 is Gln, Asn or Lys; R.sub.27 is leu, Ile, ala, Val, Nva, Met, Nle, Phe, Asp, Asn, Gln or Glu; R.sub.28 is ala, Arg or Lys; R.sub.29 is Gln or Glu, R.sub.32 is His, Gly, Tyr or ala; R.sub.33 is Ser, Asn, leu, Thr or ala; R.sub.36 is Lys, Orn, Arg, Har or leu; R.sub.37 is leu or Tyr; R.sub.38 is Met or leu; R.sub.39 is Glu or Asp; R.sub.40 is Ile, Thr, Glu, ala, Val, leu, Nle, Phe, Nva, Gly or Gln; and R.sub.41 is ala, Ile, Gly, Val, leu, Nle, Phe, Nva or Gln; ala representing either L-Ala or C.alpha.CH.sub.3 -L-Ala and leu representing either L-Leu or C.alpha.CH.sub.3 -L-Leu; and a pharmaceutically or veterinarily acceptable liquid or solid carrier therefor.