Patent Document ID: 20130244236
Application ID: 13787137
Patent Flag: 0

Claim One:
1. A method for evaluating the risk of a major adverse cardiac event (MACE) for a subject within one year, the method comprising: performing an assay to determine a first level of soluble ST2 in a biological sample obtained from a subject at a first time point (ST2 T0); performing an assay to determine a second level of soluble ST2 in a biological sample obtained from the subject at a second time point (ST2 T1); performing an assay to determine a level of a natriuretic peptide (NP) in a biological sample obtained from the subject at the second time point (NP T1); determining a MACE risk score (MACERS) for a subject based upon, at least in part, the ratio of ST2 T1 to ST2 T0, in combination with a weighted logarithm of NP T1; comparing the MACERS determined for the subject to a reference MACERS; and identifying a subject having an elevated MACERS as compared to the reference MACERS as having an increased risk of a MACE within one year or identifying a subject having a decreased MACERS as compared to the reference MACERS as not having an increased risk of a MACE within one year.