Patent Document ID: 9956213
Application ID: 15603286
Patent Flag: 1

Claim One:
1. A method of treating a subject in need of enhancement of memory or cognition, comprising administering to the subject in need of such treatment an effective amount of at least one chemical entity, wherein the chemical entity is selected from the group consisting of compounds of Formula (I) and pharmaceutically acceptable salts of compounds of Formula (I) wherein: n is 1 or 2; Y is CH; R 1 is a pyridine substituted with -CF 3 , or phenyl substituted only in the meta and para positions with a total of one, two, or three R a members; each R a is independently selected from the group consisting of halo, -C 1-4 alkyl, CF 3 , -NO 2 , and -OC i-4 alkyl; R 2 is -C(R b ) 2 R c or -CO-R d ; each R b is independently selected from the group consisting of -H, -F, and -C 1-  3 alkyl, or optionally two R b members are taken together with the carbon to which they are attached to form a C 3-6 cycloalkyl ring; R c is selected from the group consisting of -F, -NH 2 , -OH, -OC i-3 alkyl, -CH 2 OH, -CN, -0O 2 -C 1-4 alkyl, -CO-NHR e , and -C(CH 3 ) 2 0H; provided that when at least one R b is -F then R c is not -F; R d is selected from the group consisting of -CH 3 , OC i-4 alkyl, -NHR e , and -NHCH 2 CH 2 N(R e ) 2 ; each R e is independently -H or -CH 3 ; and R 3 is selected from the group consisting of -H, -CH 3 , -OH, and -CF 3 .