Patent Document ID: 20100081648
Application ID: 11990049
Patent Flag: 0

Claim One:
1. A method of identifying a gene or a plurality of genes associated with cognitive impairment in a mammal comprising the steps of: (a) providing an AI population of aged mammals with cognitive impairment; (b) providing an AU population of aged mammals without cognitive impairment; (c) providing a Y population of young mammals; (d) determining the abundance of a plurality of expressed gene products in one or more of the CA1, CA3, and DG hippocampal tissue of each mammal in the AI, AU and Y populations; and (e) selecting a gene or a plurality of genes based on a significant increase or decrease in the relative abundance of the gene's expressed gene product in the AI population of mammals relative to the combined AU and Y populations or in the AU population of mammals relative to the combined AI and Y populations.