Patent Document ID: 20020049159
Application ID: 08937755
Patent Flag: 0

Claim One:
1. A method of treating amyotrophic lateral sclerosis, comprising administering a morphogen comprising a dimeric protein having an amino acid sequence selected from the group consisting of a sequence: (a) having at least 70% homology with the C-terminal seven-cysteine skeleton of human OP-1, residues 330-431 of SEQ ID NO:2; (b) having greater than 60% amino acid sequence identity with said C-terminal seven-cysteine skeleton of human OP-1; (c) defined by Generic Sequence 7, SEQ ID NO:4; (d) defined by Generic Sequence 8, SEQ ID NO:5; (e) defined by Generic Sequence 9, SEQ ID NO:6; (f) defined by Generic Sequence 10, SEQ ID NO:7, and (g) defined by OPX, SEQ ID NO:3, wherein said morphogen stimulates production of an N-CAM or L1 isoform by an NG108-15 cell in vitro.