Patent Document ID: 20170017751
Application ID: 15249401
Patent Flag: 0

Claim One:
1. A method for identifying a candidate individual for participation in a clinical trial using an ancestral-specific reference genome constructed by steps comprising: a) obtaining a familial genome data set comprising DNA sequences from members of the candidate individual's family; b) comparing the DNA sequences within the familial genome data set to obtain a corrected familial genome data set; c) preparing a first composite familial genome data set from the corrected familial genome data set; d) repeating steps a-c for a second, third or more families to obtain a second, third or more composite familial genome data sets; e) evaluating the first, second, third or more composite familial genome data sets for single nucleotide polymorphisms (SNPs) and/or haplotypes and assigning statistical significance to the SNPs and/or haplotypes; f) grouping the first, second, third or more composite familial genome data sets based on single nucleotide polymorphisms (SNPs) and/or haplotypes that are statistically significant; g) preparing the ancestral-specific reference genome by compiling the SNPs and/or haplotypes shared by a group of composite familial genome data sets with the same ancestry; and h) comparing a DNA sequence of the candidate individual's genome with the ancestral-specific reference genome, wherein the presence or absence of a clinically relevant genetic marker indicates that the individual is or is not a candidate for participation in the clinical trial.