Patent Document ID: 9358214
Application ID: 10453848
Patent Flag: 1

Claim One:
1. A method for the treatment of hypertension comprising administering to a patient in need thereof a pharmaceutical formulation comprising: a) a core particle comprising propranolol or a pharmaceutically acceptable salt thereof; b) a first layer disposed over the core particle comprising a first water insoluble polymer; and c) a second layer disposed over the first layer comprising a mixture of a second water insoluble polymer and an enteric polymer, wherein the second layer provides a lag time in propranolol blood plasma concentration of from about 2 to about 6 hours; wherein the pharmaceutical formulation comprises about 80 mg, about 120 mg, or about 160 mg of propranolol or a pharmaceutically acceptable salt thereof, and wherein the pharmaceutical formulation provides a maximum blood plasma concentration (C max ) between about 10 and about 14 hours following administration.