Patent Document ID: 20120065700
Application ID: 13297688
Patent Flag: 0

Claim One:
1. A method of treating Parkinson's disease (PD) in a patent, the method comprising: for a first time period, applying a first electrical deep brain stimulation regimen to the patient for neuroplastic priming to cause a change in neuronal circuitry from a disease state, wherein the first time period extends for at least multiple days; and after the first time period, applying a second electrical deep brain stimulation regimen to the patient wherein (i) the second electrical deep brain stimulation regimen employs a reduced amount of time of application of electrical stimulation to the patient per day relative to the first electrical deep brain stimulation regimen, and (ii) the second electrical deep brain stimulation regimen comprises: (a) generating electrical stimulation pulses from a pulse generator, the electrical stimulation pulses comprising a plurality of groups of pulses occurring according to a burst frequency, wherein (i) multiple pulses are generated within each respective group according to a pulse repetition frequency, and (ii) adjacent groups within the plurality of groups are spaced apart from each other in time with a substantially quiescent period; and (b) applying the plurality of groups of pulses to a target neuronal population of the patient using one or more electrodes of one or more electrical leads implanted within a deep brain location of the patient, wherein (i) the target neuronal population is within the globus pallidus internalis (GPi) or within or immediately adjacent to the subthamalic nucleus (STN), and (ii) the applying causes the patient to maintain or experience a change in neuronal circuitry from a disease state that results in improved motor functioning in the patient while the electrical stimulation pulses are not applied.