Patent Document ID: 8594410
Application ID: 12930873
Patent Flag: 1

Claim One:
1. A method comprising: acquiring pixel values of medical images of patients; generating objects of a data network for each of the medical images by linking selected pixel values to selected objects according to a class network and a process hierarchy; measuring the objects to obtain a value for each of a plurality of image features; selecting a first subset of the image features that belong to a first image-based biomarker; correlating the first image-based biomarker for each of the patients with a clinical endpoint observed for that patient; displaying on a graphical user interface how the first image-based biomarker correlates with the clinical endpoint observed for each of the patients; identifying a subgroup of the patients for which the first image-based biomarker correlates poorly with the clinical endpoints observed for the patients in the subgroup; and selecting a second subset of the image features that belong to a second image-based biomarker that better correlates with the clinical endpoints observed for the patients in the subgroup.