Patent Document ID: 7985586
Application ID: 12365381
Patent Flag: 1

Claim One:
1. A cell culture comprising a cell culture medium comprising a ceramide compound in combination with a S1P receptor agonist, wherein said cell culture is enriched with oligodendrocyte precursor cells (ODPCs) capable of further differentiating into oligodendrocytes in vivo without forming teratomas, wherein said ceramide compound is N-(2-hydroxy-1-(hydroxymethyl)ethyl)-oleoylamide (S18), and wherein said S1P receptor agonist is selected from the group consisting of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol (FTY720), (S)-phosphoric acid mono-[2-amino-3-(4-octyl-phenylamino)-propyl]ester (VPC24191), and a tetraaromatic compound SEW2871.