Patent Document ID: 20160129277
Application ID: 13662138
Patent Flag: 0

Claim One:
1. A compound of formula: and pharmaceutically acceptable salts thereof, wherein R 1 and R 2 are independently C 1 -C 12 alkyl, halo(C 1 -C 12 alkyl), C 2 -C 12 alkenyl, or C 2 -C 12 alkynyl, each optionally substituted with 1, 2, 3 or 4 substituents selected from halogen, —CN, —NO 2 , —OR 6 , —NR 6 2 , —CO 2 R 6 , —CONR 6 2 , C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkenyl, aryl, heteroaryl, and heterocycle, wherein each cycloalkyl, cycloalkenyl, aryl, heteroaryl, and heterocycle is optionally substituted with 1, 2, 3 or 4 R 7 ; R 3 is hydrogen, C 1 -C 6 alkyl, or halo(C 1 -C 6 alkyl); R 4 and R 5 are independently halogen, —CN, —NO 2 , C 1 -C 6 alkyl, halo(C 1 -C 6 alkyl), —OR 6 , —NR 6 2 , —CO 2 R 6 , or —CONR 6 2 ; X is —N(R 8 )—, —N(R 8 )CH 2 —, —N(R 8 )CHR 8 —, —N(R 8 )(CHR 8 ) 2-5 —, or —O—; Y═Z is —N═N— or —C(R 8 )═C(R 8 )—; and R 9 is hydrogen, —CHR 6a , —OR 6a , —NR 6a 2 , —CO 2 R 6a , —CONR 6a 2 , —CON(R 8 )—(CH 2 ) 1-6 —NR 6a 2 , —N(R 8 )CO—(CH 2 ) 1-6 —NR 6a 2 , —CON(R 8 )—(CH 2 ) 1-6 —N(R 8 )COR 6a , —N(R 8 )CO—(CH 2 ) 1-6 —N(R 8 )COR 6a , —CON(R 8 )—(CH 2 ) 1-6 —N(R 8 )COR 10 , or —N(R 8 )CO—(CH 2 ) 1-6 —N(R 8 )COR 10 , wherein R 10 is —CH 2 CH 2 (OCH 2 CH 2 ) 2-50 —N(R 8 )COR 6a ; where each R 6 independently is hydrogen, C 1 -C 6 alkyl, halo(C 1 -C 6 alkyl), C 3 -C 8 cycloalkyl, aryl, heteroaryl, heterocycle, aryl(C 1 -C 6 alkyl)-, C 3 -C 8 cycloalkyl(C 1 -C 6 alkyl)-, aryl(C 1 -C 6 alkyl)-, heteroaryl(C 1 -C 6 alkyl)-, or heterocycle(C 1 -C 6 alkyl)-, wherein each alkyl, cycloalkyl, aryl, heteroaryl, and heterocycle is optionally substituted with 1, 2, 3 or 4 R 7 , or two R 6 with the nitrogen to which they are attached form a heterocycle optionally substituted with 1, 2, 3 or 4 R 7 ; where each R ha independently is hydrogen, C 1 -C 6 alkyl, halo(C 1 -C 6 alkyl), C 3 -C 8 cycloalkyl, aryl, heteroaryl, heterocycle, aryl(C 1 -C 6 alkyl)-, C 3 -C 8 cycloalkyl(C 1 -C 6 alkyl)-, aryl(C 1 -C 6 alkyl)-, heteroaryl(C 1 -C 6 alkyl)-, or heterocycle(C 1 -C 6 alkyl)-, wherein each alkyl, cycloalkyl, aryl, heteroaryl, and heterocycle is optionally substituted with 1, 2, 3 or 4 R 7 , or two R 6 with the nitrogen to which they are attached form a heterocycle optionally substituted with 1, 2, 3 or 4 R 7 ; where each R 7 independently is halogen, —CN, —NO 2 , —N 3 , C 1 -C 6 alkyl, halo(C 1 -C 6 alkyl), C 1 -C 6 alkoxy, amino, C 1 -C 6 alkylamino, diC 1 -C 6 alkylamino, —CO 2 H, —COH, —CO 2 R 8 , or —CON(R 8 ) 2 ; and where each R 8 independently is hydrogen or C 1 -C 6 alkyl.