Patent Document ID: 20030203418
Application ID: 10439902
Patent Flag: 0

Claim One:
1. A method for selecting a candidate drug for treating sepsis, comprising: (i) selecting a model system of sepsis, said model system comprising an animal species and a pathogen species capable of causing sepsis in said animal species, in which model system a critical rate of pathogen load increase has been ascertained; (ii) infecting an experimental animal of said animal species with a dose of reporter-labeled pathogen of said pathogen species, where said dose is sufficient to result in a rate of pathogen load increase exceeding said critical rate; (iii) administering a test drug to said experimental animal; (iv) measuring the level of said reporter in said experimental animal; and (v) selecting said test drug as a candidate drug for treating sepsis if said test drug is effective to decrease the rate of pathogen load increase in the experimental animal below said critical rate of pathogen load increase.