Patent Document ID: 20130190386
Application ID: 13746589
Patent Flag: 0

Claim One:
1. A method of determining whether a human subject has a poor survival prognosis for breast cancer (BC), comprising: measuring the level of a miRNA/mRNA signature in a test sample of tissue from the human subject, the miRNA/mRNA signature consisting of: i) miRNA gene products: hsa-miR-103, hsa-miR-1307, hsa-miR-148b, hsa-miR-324, hsa-miR-326, hsa-miR-328, hsa-miR-365, hsa-miR-484, hsa-miR-874a, hsa-miR-93; and, ii) mRNA gene products: ADAT1, ANKRD52, BIRC6, C10orf18, C2CD2, CHD9, CHM, CPT1A, DAAM1, DIP2B, DPY19L3, FAM91A1, GMCL1, ME1, NCOA2, OTUD6B, PDSS2, PIK3CA, SMG1, TRIM23, TTC3, UBR5, UBXN7 and ZFC3H1; and, determining the survival prognosis of the subject; wherein an alteration in the levels of the miRNA and mRNA gene products in the test sample, relative to the level of corresponding levels of miRNA and mRNA gene products in a control sample of cancer free tissue, is indicative of the human subject having a poor survival prognosis for BC.