Patent Document ID: 9500655
Application ID: 14279905
Patent Flag: 1

Claim One:
1. A kit for determining whether or not an individual with AML will respond to treatment comprising (i) an apoptosis-inducing agent selected from the group consisting of Staurosporine, Etoposide, Mylotarg, Daunorubicin, and AraC, and combinations thereof; (ii) a binding element specific for a cell surface marker selected from the group consisting of CD34, CD33, CD45, HLADR, CD11B, FLT3 Ligand, c-KIT, ABCG2, MDR1, BCRP, MRP1, LRP, and combinations thereof; and (iii) a state-specific binding element specific for an activatable element selected from the group consisting of PARP+, Cleaved Caspase 3, Cleaved Caspase 8, and Cytochrome C.