Patent Document ID: 8340915
Application ID: 11866964
Patent Flag: 1

Claim One:
1. A computer implemented method of analyzing data obtained from a plurality of microarrays, wherein said data are arranged in the form of data grids corresponding to the respective physical grids of the microarrays from which the data were obtained, said method comprising the steps of: inputting said microarray data to a processing unit configured to perform the steps of: selecting a first microarray and a second microarray for comparison; normalizing, pairwise, the second microarray against the first microarray by preforming the following steps: dividing data from each of the two microarrays into equal number of subarrays of a predetermined size, wherein said subarrays either do not overlap or overlap with adjacent subarrays by a predetermined overlap percentage; estimating a linear relationship between a subarray of the first microarray and a corresponding subarray of the second microarray by applying a least trimmed squares regression method with a predetermined trimming fraction; transforming data in the corresponding subarray of the second microarray by applying the estimated linear relationship; applying the estimating and transforming steps to the remaining subarrays until all subarrays in the second microarray have been transformed; and outputting the transformed values of the second microarray as normalized microarray data of the second microarray against the first microarray.