Patent Document ID: 4594329
Application ID: 06610110
Patent Flag: 1

Claim One:
1. A composition for lowering the blood pressure of mammals comprising an effective amount of a synthetic CRF peptide or a nontoxic addition salt thereof having the sequence: R.sub.1 -R.sub.2 -R.sub.3 -R.sub.4 -R.sub.5 -Ile-Ser-R.sub.8 -R.sub.9 -leu-R.sub.11 -R.sub.12 -R.sub.13 -leu-leu-Arg-R.sub.17 -R.sub.18 -R.sub.19 -Glu-R.sub.21 -R.sub.22 -R.sub.23 -R.sub.24 -R.sub.25 -R.sub.26 -R.sub.27 -R.sub.28 -R.sub.29 -Gln-ala-R.sub.32 -R.sub.33 -Asn-Arg-R.sub.36 -R.sub.37 -R.sub.38 -R.sub.39 -R.sub.40 -R.sub.41 wherein R.sub.1 is Ser, D-Ser or des R.sub.1 ; R.sub.2 is Gln, pGlu, Glu, D-pGlu or des R.sub.2 ; R.sub.3 is Glu, Gly, D-Tyr or des R.sub.3 ; R.sub.4 is Pro, D-Pro or des R.sub.4 ; R.sub.5 is Pro or desR.sub.5 ; R.sub.8, R.sub.12, R.sub.19 and R.sub.24 are selected from the group consisting of leu, Ile, ala, Gly, Val, Nle, Phe and Gln; R.sub.9 is Asp or Glu; R.sub.11 is Thr or Ser; R.sub.13 is His, Tyr or Glu; R.sub.17 is Glu or Lys; R.sub.18 is Val, Nle or Met; R.sub.21 is Met, Nva, Ile, ala, leu, Nle, Val, Phe or Gln; R.sub.22 is ala, Thr, Asp or Glu; R.sub.23 is Arg, Orn, Har or Lys; R.sub.25 is Asp or Glu; R.sub.26 is Gln, Asn or Lys; R.sub.27 is leu, Ile, ala, Val, Nva, Met, Nle, Phe, Asp, Asn, Gln or Glu; R.sub.28 is ala, Arg or Lys; R.sub.29 is Gln or Glu, R.sub.32 is His, Gly, Tyr or ala; R.sub.33 is Ser, Asn, leu, Thr or ala; R.sub.36 is Lys, Orn, Arg, Har or Leu; R.sub.37 is leu or Tyr; R.sub.38 is Met or leu; R.sub.39 is Glu or Asp; R.sub.40 is Ile, Thr, Glu, ala, Val, leu, Nle, Phe, Nva, Gly or Gln; R.sub.41 is ala, Ile, Gly, Val, Leu, Nle, Phe, Gln or des R.sub.41, provided however that R.sub.3 is D-Tyr or R.sub.4 is D-Pro or R.sub.28 is Arg or R.sub.29 is Glu- or R.sub.40 is Glu or R.sub.36 is either Arg oor Har or R.sub.37 is Tyr, wherein leu is L-leucine or C.alpha.CH.sub.3 -L-leucine (CML) and ala is L-alanine or C.alpha.CH.sub.3 -L-alanine (CMA); and a pharmaceutically or veterinarily acceptable liquid or solid carrier therefor.