Patent Document ID: 20060205003
Application ID: 11429628
Patent Flag: 0

Claim One:
1. A method of defining a library of biological molecules, the method comprising: (a) receiving an original set of data points representing activity and sequence of multiple biological molecules in a training set; (b) constructing a bootstrap set of data points selected, with replacement, from the original set of data points; (c) generating a model from the bootstrap set, which model comprises indicators of the relative importance of individual residues or other units in biological molecules represented by the data points in the bootstrap set; (d) repeating (b) and (c) multiple times to generate multiple values of each indicator from the model generated in (c); (e) for each indicator, determining (i) an average or mean value of the multiple values and (ii) a statistical indication of the distribution of the multiple values; (f) ranking the individual residues or other units on basis of their respective values of (i) and (ii) determined in (e); and (g) toggling particular ones of the individual residues or other units based on rankings produced in (f) to thereby define the library of biological molecules.