Patent Document ID: 20090138251
Application ID: 11945692
Patent Flag: 0

Claim One:
1. A method for determining genotype to phenotype analysis for the application of specific drug treatments for identified genes comprising the steps of: identifying at least one condition-specific genomic, proteomic or metabolic profile; identifying a statistically significant discriminator; accessing a global network defining known biological molecular processes; identifying a set of condition-specific nodes in the global network; calculating at least one shortest network path from a first node (j) to every other condition-specific node wherever a path exists in the global network; counting the number of condition specific nodes connected to the first node (j) by the shortest path containing a second node (i); determining a pre-calculated table of the shortest network paths from every node in the global network of interactions to all other nodes wherever such directed paths exist; counting the total number of nodes that are connected to the first node (j) by a shortest paths containing the second node (i) in the global network; calculating a probability score using a hypergeometric distribution with parameters determined by the number of nodes in the global network and number of condition specific nodes and number of nodes connected to the first node (j) by the shortest network paths containing the second node (i); and utilizing the probability score for providing connectivity among genes or proteins of interest to assess role of nodes in the application of specific drug treatments.