Patent Document ID: 20090093969
Application ID: 12200568
Patent Flag: 0

Claim One:
1. A software assisted method of discovering in a sample from an animal biomarkers indicative of a biological state of a cell, tissue, organ, organ system, or organism, the method comprising the steps of: a) providing in a storage medium one or more models representative of one or more causative or characteristic biophysical or biochemical relationships underlying said biological state in said cell, tissue, organ, organ system, or organism and comprising nodes representing a biological entity, action, functional activity, or concept, and links between nodes indicative of there being a relationship therebetween, at least some of which include indicia of causal directionality; b) providing a candidate set of data representative of biomolecules, or concentration relationships therebetween, determined by analysis of a sample from a animal in said biological state, and comprising lymph, tears, urine, blood, serum, plasma, saliva, amniotic fluid, cerebro-spinal fluid, stool, tissue lysate preparations, cell lysate preparations, or fractions thereof, which are hypothesized to be indicative of the biological state of said cell, tissue, organ, organ system, or organism; c) comparing said candidate set of data with said model to discern which of said biomolecules or concentration relationships therebetween are indicative of the biological state or which are not directly related to said biological state, thereby to discern a candidate biomarker for said biological state; and d) causing an electronic representation of the candidate biomarker to be physically stored on a computer-readable medium.