Patent Document ID: 7599799
Application ID: 10273489
Patent Flag: 1

Claim One:
1. A method of determining a disease profile that best matches a patient profile, comprising: (a) comparing, on a suitably programmed computer, a patient profile with reference profiles in a reference database to determine a measure of similarity between said patient profile and each said reference profiles, wherein said patient profile is obtained by projecting a first profile comprising measurements of a plurality of cellular constituents in a cell sample from said patient onto co-varying basis cellular constituent sets, and wherein said reference profiles are obtained by respectively projecting disease profiles each comprising measurements of said plurality of cellular constituents in a disease cell sample onto said co-varying basis cellular constituent sets, said co-varying basis cellular constituent sets being determined based upon co-variation of measurements of cellular constituents, under a plurality of different perturbations; (b) identifying, on a suitably programmed computer, a reference profile in said reference database that best matches said patient profile based on a maximum similarity among the measures of similarity determined in step (a); and (c) outputting to a user interface device, a computer readable storage medium, or a local or remote computer system; or displaying, said maximum similarity or the disease of said disease cell sample of the reference profile in said reference database that best matches said patient profile.