Patent Document ID: 7745166
Application ID: 12175427
Patent Flag: 1

Claim One:
1. A method for diagnosis for Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL) comprising: (a) obtaining a biological sample from a subject to be diagnosed; (b) measuring the amount of CLN2 pepstatin-insensitive carboxyl protease activity in the biological sample; and (c) comparing the amount of CLN2 pepstatin-insensitive carboxyl protease activity obtained from step (b) with the amount of CLN2 pepstatin-insensitive carboxyl protease activity in a biological sample from a normal control subject, wherein a lower amount of CLN2 pepstatin-insensitive carboxyl protease activity obtained from step (b) than the amount obtained from the normal control subject is indicative of the presence of LINCL.