Patent Document ID: 20100185257
Application ID: 12597196
Patent Flag: 0

Claim One:
1. Method for filtering the signal of neuronal activity during a high frequency deep brain stimulation (DBS) to remove a stimulus artefact in the observed signal, comprising: i) approximating the observed signal trajectories in phase space, the observed signal being considered as a sum of the stimulation artefacts induced by the signal of stimulation, wherein the signal of stimulation is assumed to be a solution of an ordinary differential equation including a self-oscillating system with stable limit cycle, ii) slicing the observed signal and its derivative into segments, each segment corresponding to a period of stimulation, iii) collecting N selected periods of stimulation to a training set, iv) collecting the limit cycle of the self-oscillating system, v) synchronizing each artefact of the observed signal with the estimated limit cycle, vi) subtracting the estimated limit cycle from each artefact in phase space according to the synchronization, vii) collecting all segments in order to obtain whole filtered signal, and viii) presenting the results in time domain.