Patent Document ID: 10058619
Application ID: 15306978
Patent Flag: 1

Claim One:
1. A composition comprising a p97 conjugate and a pharmaceutically acceptable carrier, where the conjugate comprises at least one isolated p97 polypeptide of up to 50 amino acids in length, where the polypeptide comprises an amino acid sequence at least 80% identical to DSSHAFTLDELR (SEQ ID NO:14), and where the p97 polypeptide is covalently linked to a) a first polynucleotide of about 15-40 nucleotides in length with or without a linker (L) in between, and (b) a second polynucleotide of about 15-40 nucleotides in length which is complementary to and hybridized to the first polynucleotide, where the first or second polynucleotide is an antisense strand that is complementary to a target mRNA sequence of a human NOX4 gene.