Patent Document ID: 7860660
Application ID: 12574195
Patent Flag: 1

Claim One:
1. A method for the characterization of phenotypes by gene expression patterns and classification of samples based thereon, wherein the method is run on a system comprising one or more distinct devices, each of the one or more distinct devices being embodied on a tangible computer-readable recordable storage medium, the method comprising: a) forming, from a plurality of first genes and first samples of a first phenotype, a first matrix of gene expression signals for the first phenotype, each gene expression signal corresponding to one of the first genes and one of the first samples, wherein forming a first matrix of gene expression signals for the first phenotype is carried out by a data storage device executing on a hardware processor; b) forming, from a plurality of selected genes and selected samples of a selected phenotype, a second matrix of gene expression signals for the selected phenotype, each gene expression signal corresponding to one of the selected genes and one of the selected samples, wherein each selected gene corresponds to one of the first genes, wherein forming a second matrix of gene expression signals for the selected phenotype is carried out by a data storage device executing on a hardware processor; c) deriving a plurality of transformations, wherein each transformation transforms a probability density distribution of gene expression signals within a selected interval of the gene expression signals for one of the first genes to a uniform probability density distribution of gene expression signals, whereby each transformation corresponds to a selected gene, wherein deriving a plurality of transformations is carried out by a data storage device executing on a hardware processor; d) applying, for each of the selected genes, one of the transformations to the gene expression signals of a corresponding one of the selected genes of the second matrix, wherein applying one of the transformations to the gene expression signals of a corresponding one of the selected genes of the second matrix is carried out by a data storage device executing on a hardware processor; and e) defining at least one submatrix of the second matrix, wherein each transformed gene expression signal for each gene of the submatrix falls within a selected range, wherein defining at least one submatrix of the second matrix is carried out by a data storage device executing on a hardware processor.