Patent Document ID: 10113183
Application ID: 15493622
Patent Flag: 1

Claim One:
1. A recombinant nucleic acid molecule comprising a G6PC promoter/enhancer, a synthetic intron, and a G6PC coding region, wherein the nucleotide sequence of the recombinant nucleic acid molecule is at least 95% identical to nucleotides 182-4441 of SEQ ID NO: 1, and wherein the recombinant nucleic acid comprises at least one nucleotide substitution in the G6PC coding region that results in a coding change at residue 3, 54, 139, 196, 199, 242, 247, 292, 298, 301, 318, 324, 332, 347, 349, 350 or 353 of the human G6PC protein of SEQ ID NO: 4.