Patent Document ID: 20120115863
Application ID: 13062625
Patent Flag: 0

Claim One:
1. A compound according to general formula (I) wherein A is selected from the group A 1 consisting of a C 3 -C 8 -cycloalkyl group or a C 4 -C 8 -cycloalkenyl group, whereby the members of C 3 -C 8 -cycloalkyl group being selected from the group of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptanyl and cyclooctanyl, and the members of the C 4 -C 8 -cycloalkenyl group, being selected from cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, cyclopentadienyl, cyclohexadienyl, cycloheptadienyl, cyclooctadienyl, cycloheptatrienyl, cyclooctatrienyl, cyclooctatetraenyl; R 1 is selected from the group R 1.1 consisting of C 1-8 -alkyl-, C 2-8 -alkenyl-, C 2-8 -alkynyl-, R 10 —S—C 1-3 -alkyl-, R 10 —O—C 1-3 -alkyl-, C 3-7 -cycloalkyl-C 3-7 -cycloalkyl-C 1-6 -alkyl-, C 3-7 -cycloalkyl-C 2-6 -alkenyl-, C 3-7 -cycloalkyl-C 2-6 -alkynyl-, C 3-8 -heterocycloalkyl-, C 3-8 -heterocycloalkyl-C 1-6 -alkyl-, C 3-8 -heterocycloalkyl-C 2-6 -alkenyl-, C 3-8 -heterocycloalkyl-C 2-6 -alkynyl-, aryl, aryl-C 1-6 -alkyl-, aryl-C 2-6 -alkenyl-, aryl-C 2-6 -alkynyl-, heteroaryl, heteroaryl-C 1-6 -alkyl-, heteroaryl-C 2-6 -alkenyl- and heteroaryl-C 2-6 -alkynyl-, where the above mentioned members may optionally be substituted independently of one another by one or more substituents selected from the group consisting of fluorine, chlorine, bromine, iodine, oxo, whereby this oxo group preferably is only a substituent for a cycloalkyl group or a heterocycloalkyl group, HO—, NC—, O 2 N—, F 3 C—, HF 2 C—, FH 2 C—, F 3 C—CH 2 —, F 3 C—O—, HF 2 C—O—, HO—C 1-6 -alkyl-, R 10 —O—C 1-6 -alkyl-, R 10 —S—C 1-6 -alkyl-, C 1-6 -alkyl-, C 3-7 -cycloalkyl-, C 3-7 -cycloalkyl-C 1-6 -alkyl-, C 3-7 -cycloalkyl-O—, C 3-7 -cycloalkyl-C 1-6 -alkyl-O—, aryl, aryl-C 1-6 -alkyl-, heteroaryl, heteroaryl-C 1-6 -alkyl-, heteroaryl-O—, heteroaryl-C 1-6 -alkyl-O—, C 3-8 -heterocycloalkyl-, C 3-8 -heterocycloalkyl-C 1-6 -alkyl-, C 3-8 -heterocycloalkyl-O— with C 3-8 -heterocycloalkyl being bound to O via one of its ring C-atoms, C 3-8 -heterocycloalkyl-C 1-6 -alkyl-O— with C 3-8 -heterocycloalkyl being bound to the C 1-6 -alkyl- via one of its ring-C-atoms, (R 10 ) 2 N—, (R 10 ) 2 N—C 1-6 -alkyl-, R 10 —O—, R 10 —S—, R 10 —CO—, R 10 O—CO—, (R 10 ) 2 N—CO—, (R 10 ) 2 N—CO—C 1-6 -alkyl-, R 10 —CO—(R 10 )N—, R 10 —CO—(R 10 )N—C 1-6 -alkyl-, R 10 —CO—O—, R 10 O—CO—O—, R 10 O—CO—O—C 1-6 -alkyl-, R 10 O—CO—(R 10 )N—, R 10 O—CO—(R 10 )N—C 1-6 -alkyl-, (R 10 ) 2 N—CO—O—, (R 10 ) 2 N—CO—O—C 1-6 -alkyl-, (R 10 ) 2 N—CO—(R 10 )N—C 1-6 -alkyl-, R 10 —SO 2 —(R 10 )N—, R 10 —SO 2 —(R 10 )N—C 1-6 -alkyl-, (R 10 ) 2 N—SO 2 —(R 10 )N—C 1-6 -alkyl-, (R 10 ) 2 N—SO 2 —, (R 10 ) 2 N—SO 2 —C 1-6 -alkyl-, and C 1-6 -alkyl-SO 2 —, whereby any of the C 3-7 -cycloalkyl-, C 3-8 -heterocycloalkyl-, aryl-, heteroaryl-groups mentioned in the latter paragraph may optionally be substituted by fluorine, chlorine, bromine, HO—, NC—, O 2 N—, F 3 C—, HF 2 C—, FH 2 C—, F 3 C—CH 2 —, F 3 C—O—, HF 2 C—O—, C 3-8 -heterocycloalkyl-, R 10 —O—C 1-6 -alkyl-, R 10 —S—C 1-6 -alkyl-, C 1-6 -alkyl-, (R 10 ) 2 N—, (R 10 ) 2 N—C 1-6 -alkyl-, R 10 —O—, R 10 —S—, R 10 —CO—, R 10 O—CO—, (R 10 ) 2 N—CO—, (R 10 ) 2 N—CO—C 1-6 -alkyl-, R 10 —CO—(R 10 )N—, R 10 —CO—(R 10 )N—C 1-6 -alkyl-, R 10 —CO—O—, R 10 O—CO—O—, R 10 O—CO—O—C 1-6 -alkyl-, R 10 O—CO—(R 10 )N—, R 10 O—CO—(R 10 )N—C 1-6 -alkyl-, (R 10 ) 2 N—CO—O—, (R 10 ) 2 N—CO—(R 10 )N—, (R 10 ) 2 N—SO 2 —(R 10 )N—, (R 10 ) 2 N—CO—O—C 1-6 -alkyl-, (R 10 ) 2 N—CO—(R 10 )N—C 1-6 -alkyl-, R 10 —SO 2 —(R 10 )N—, R 10 —SO 2 —(R 10 )N—C 1-6 -alkyl-, (R 10 ) 2 N—SO 2 —) (R 10 )N—C 1-6 -alkyl-, (R 10 ) 2 N—SO 2 —, (R 10 ) 2 N—SO 2 —C 1-6 -alkyl-, and C 1-6 -alkyl-SO 2 —; R 2 is selected from the group R 2.1 consisting of fluorine, NC—, F 3 C—, HF 2 C—, FH 2 C—, F 3 C—CH 2 —, carboxy-, C 1-6 -alkyl-, C 2-6 -alkenyl-, C 2-6 -alkynyl-, R 10 —S—, R 10 —S—C 1-3 -alkyl-, C 3-7 -cycloalkyl-, C 3-7 -cycloalkyl-C 1-6 -alkyl-, C 3-7 -cycloalkyl-C 2-6 -alkenyl-, C 3-7 -cycloalkyl-C 2-6 -alkynyl-, C 3-8 -heterocycloalkyl-, C 3-8 -heterocycloalkyl-C 1-6 -alkyl-, C 3-8 -heterocycloalkyl-C 2-6 -alkenyl-, C 3-8 -heterocycloalkyl-C 2-6 -alkynyl-, aryl, aryl-C 1-6 -alkyl-, aryl-C 2-6 -alkenyl-, aryl-C 2-6 -alkynyl-, heteroaryl-, heteroaryl-C 1-6 -alkyl-, heteroaryl-C 2-6 -alkenyl-, heteroaryl-C 2-6 -alkynyl-, R 10 —O—, R 10 —O—C 1-3 -alkyl-, (R 10 ) 2 N—, R 10 O—CO—, (R 10 ) 2 N—CO—, R 10 —CO—(R 10 )N—, R 10 —CO—, (R 10 ) 2 N—CO—(R 10 )N—, R 10 —O—CO—(R 10 )N—, R 10 —SO 2 —(R 10 )N—, and C 1-6 -alkyl-SO 2 —, where the above mentioned members C 1-6 -alkyl-, C 2-6 -alkenyl-, C 2-6 -alkynyl-, R 10 —S—, R 10 —S—C 1-3 -alkyl-, C 3-7 -cycloalkyl-C 2-6 -alkenyl-, C 3-7 -cycloalkyl-C 2-6 -alkynyl-, C 3-8 -heterocycloalkyl-, C 3-8 -heterocycloalkyl-C 1-6 -alkyl-, C 3-8 -heterocycloalkyl-C 2-6 -alkenyl-, C 3-8 -heterocycloalkyl-C 2-6 -alkynyl-, aryl, aryl-C 1-6 -alkyl-, aryl C 2-6 alkenyl, aryl-C 2-6 -alkynyl-, heteroaryl-, heteroaryl-C 1-6 -alkyl-, heteroaryl-C 2-6 -alkenyl-, heteroaryl-C 2-6 -alkynyl-, R 10 —O—, R 10 —O—C 1-3 -alkyl-, (R 10 ) 2 N—, R 10 O—CO—, (R 10 ) 2 N—CO—, R 10 —CO—(R 10 )N—, R 10 —CO—, (R 10 ) 2 N—CO—(R 10 )N—, R 10 —O—CO—(R 10 )N—, R 10 —SO 2 —(R 10 )N—, and C 1-6 -alkyl-SO 2 — may optionally be substituted independently of one another by one or more substituents selected from the group consisting of fluorine, chlorine, bromine, NC—, O 2 N—, F 3 C—, HF 2 C—, FH 2 C—, F 3 C—CH 2 —, HO—C 1-6 -alkyl-, C 1-6 -alkyl-O—, C 1-6 -alkyl-O—C 1-6 -alkyl-, C 1-6 -alkyl-, (R 10 ) 2 N—, (R 10 ) 2 N—C 1-3 -alkyl-, and (R 10 ) 2 N—CO—, or R 2.1 and R 3.1 together form a C 2-6 -alkylene bridge, wherein one or two CH 2 groups of the C 2-6 -alkylene bridge may be replaced independently of one another by O, S, SO, SO 2 , N(R 10 ) or N—C(O)—R 10 in such a way that in each case two O or S atoms or an O and an S atom are not joined together directly; R 3 independently from any other R 3 is selected from the group R 3.1 consisting of fluorine, NC—, F 3 C—, HF 2 C—, FH 2 C—, F 3 C—CH 2 —, C 1-6 -alkyl-, C 2-6 -alkenyl-, C 2-6 -alkynyl-, R 10 —S—, R 10 —S—C 1-3 -alkyl-, C 3-7 -cycloalkyl-, C 3-7 -cycloalkyl-C 1-6 -alkyl-, C 3-8 -heterocycloalkyl-, aryl, aryl-C 1-6 -alkyl-, heteroaryl-, heteroaryl-C 1-6 -alkyl-, R 10 —O—, R 10 —O—C 1-3 -alkyl-, (R 10 ) 2 N—, (R 10 ) 2 N—CO—, R 10 —CO—)(R 10 )N—, (R 10 ) 2 N—CO—(R 10 )N—, and R 10 —O—CO—(R 10 )N—, where the above mentioned members C 1-6 -alkyl-, C 2-6 -alkenyl-, C 2-6 -alkynyl-, R 10 —S—, R 10 —S—C 1-3 -alkyl-, C 3-7 -cycloalkyl-, C 3-7 -cycloalkyl-C 1-6 -alkyl-, C 3-8 -heterocycloalkyl-, aryl, aryl-C 1-6 -alkyl-, heteroaryl-, heteroaryl-C 1-6 -alkyl-, R 10 —O—, R 10 —O—C 1-3 -alkyl-, (R 10 ) 2 N—, (R 10 ) 2 N—CO—, R 10 —CO—(R 10 )N—, (R 10 ) 2 N—CO—(R 10 )N—, and R 10 —O—CO—(R 10 )N— may optionally be substituted independently of one another by one or more substituents selected from the group consisting of fluorine, chlorine, bromine, NC—, O 2 N—, F 3 C—, HF 2 C—, FH 2 C—, F 3 C—CH 2 —, HO—, HO—C 1-6 -alkyl-, C 1-6 -alkyl-O—, C 1-6 -alkyl-O—C 1-6 -alkyl-, C 1-6 -alkyl-, (R 10 ) 2 N—, (R 10 ) 2 N—C 1-3 -alkyl-, and (R 10 ) 2 N—CO—; R 4/5 is selected each independently of one another from the group R 4/5.1 consisting of H—, fluorine, F 3 C—, HF 2 C—, FH 2 C—, and C 1-3 -alkyl-, or R 4.1 and R 5.1 together with the carbon atom to which they are bound form a 3- to 6-membered cycloalkyl group, where the above mentioned members including the 3- to 6-membered cycloalkyl group formed by R 4.1 and R 5.1 may optionally be substituted independently of one another by one or more substituents selected from the group consisting of fluorine, HO—, NC—, O 2 N—, F 3 C 1-9 HF 2 C 1-9 FH 2 C—, F 3 C—CH 2 —, HO—C 1-6 -alkyl-, CH 3 —O—C 1-6 -alkyl-, C 1-6 -alkyl-, C 1-6 -alkyl-O— and (C 1-6 -alkyl-) 2 N—CO—; R 10 independently from any other R 10 is selected from the group R 10.1 consisting of H, F 3 C—CH 2-9 C 1-6 -alkyl-, C 2-6 -alkenyl-, C 3-7 -cycloalkyl-, C 3-7 -cycloalkyl-C 1-3 -alkyl-, C 3-8 -heterocycloalkyl-, C 3-8 -heterocycloalkyl-C 1-6 -alkyl-, aryl, aryl-C 1-3 -alkyl-, heteroaryl, and heteroaryl-C 1-3 -alkyl-, and in case where two R 10 groups both are bound to the same nitrogen atom they may together with said nitrogen atom form a 3 to 7 membered heterocycloalkyl ring, and wherein one of the —CH 2 -groups of the heterocyclic ring formed may be replaced by —O—, —S—, —NH—, N(C 3-6 -cycloalkyl)-, —N(C 3-6 -cycloalkyl-C 1-4 -alkyl)- or —N(C 1-4 -alkyl)- and where the above mentioned members F 3 C—CH 2 —, C 1-6 -alkyl-, C 2-6 -alkenyl-, C 3-7 -cycloalkyl-, C 3-7 -cycloalkyl-C 1-3 -alkyl-, C 3-8 -heterocycloalkyl-, C 3-8 -heterocycloalkyl-C 1-6 -alkyl-, aryl, aryl-C 1-3 -alkyl-, heteroaryl, and heteroaryl-C 1-3 -alkyl- and in case where two R 10 groups both are bound to the same nitrogen atom they may together with said nitrogen atom form a 3 to 7 membered heterocycloalkyl ring as defined above may optionally be substituted independently of one another by one or more substituents selected from the group consisting of fluorine, chlorine, bromine, HO—, NC—, O 2 N—, F 3 C—, HF 2 C—, FH 2 C—, F 3 C—CH 2 —, HO—C 1-6 -alkyl, CH 3 —O—C 1-6 -alkyl-, C 1-6 -alkyl- and C 1-6 -alkyl-O—; x is 0, 1, 2, 3 or 4, preferably being 0, 1, 2, more preferably being 0 or 1; and salts, preferably pharmaceutically acceptable salt forms thereof.