Patent Document ID: 20100069334
Application ID: 12309162
Patent Flag: 0

Claim One:
1. A method of prognosing an osteoporosis phenotype in a subject, which comprises: (I) obtaining outcomes for one or more single nucleotide polymorphism variables and one or more clinical variables for the subject; and (II) using the outcomes obtained in (I) to prognose the phenotype; wherein: (a) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained in step (I) comprise the general BSTEP model variables in FIG. 9 ; and/or (b) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained in step (I) comprise the general FSTEP model variables in FIG. 9 ; and/or (c) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained In step (I) comprise the male BSTEP model variables in FIG. 9 ; and/or (d) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained in step (I) comprise the male FSTEP model variables In FIG. 9 ; and/or (e) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained in step (I) comprise the female BSTEP model variables in FIG. 9 ; and/or (f) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained in step (I) comprise 25 the female FSTEP model variables in FIG. 9 ; and/or (g) the osteoporosis phenotype is presence of one or more non-traumatic vertebral factures and the variables for which outcomes are obtained in step (I) comprise the male vertebral factures variables or the female vertebral factures variables in Table 5; and wherein (i) an outcome for an SNP variable is the identity of the nucleotide in the genomic DNA of the subject at the position of the single nucleotide polymorphism; (ii) an outcome for the clinical variable AGE is age of the subject in years; (iii) an outcome for the clinical variable MENOPAUSE AGE is the age in years of the onset of menopause in a female subject; (iv) an outcome for the clinical variable MENARCHE AGE is the age in years of the onset of menarche in a female subject; (v) an outcome for the clinical variable BMI is the body mass index of the subject