Patent Document ID: 20030054362
Application ID: 10008107
Patent Flag: 0

Claim One:
1. A method of predicting a patient's in vivo response to a chemical entity, comprising: (i) creating a set of reference cellular responses to the chemical entity in peripheral blood mononuclear cells that are correlated with in vivo responses for a clinical indication in a population of subjects; (ii) drawing peripheral blood mononuclear cells from the patient; (iii) detecting the cellular response of the patient's peripheral blood mononuclear cells to the chemical entity; (iv) identifying the cellular response in the reference set of step (i) that corresponds to the patient's cellular response of step (iii); and (v) determining the in vivo response which correlates with the cellular response in the reference set identified in step (iv); wherein the patient is predicted to have the in vivo response determined in step (v) when exposed to the chemical entity in vivo.