Patent Document ID: 8504498
Application ID: 12867429
Patent Flag: 1

Claim One:
1. A computer program product comprising a non-transitory computer useable medium having a computer readable medium having program instructions for selecting an optimized, diverse set of molecular variants from a plurality of molecular variants, wherein the program instructions comprise: (a) code for receiving an objective data set representing two or more properties of each molecular variant in a plurality of molecular variants; (b) code for generating a first Pareto front membership of all molecular variants based on the one or more objectives for optimization; (c) code for setting optimization parameters, wherein the optimization parameters comprise: (i) number nvar of molecular variants to create; (ii) a molecular variant population size popSize; (iii) a crossover rate crossrate; (iv) a mutation rate mutrate; (v) a fitness function comprising a penalty fitness function and an overall fitness function, wherein the penalty fitness is based on niche count and the overall fitness function is based on location in a descending Pareto front divided by the shared number of molecular variants within each front; and (vi) specific molecular variants to be included in the nvar of molecular variants; and (d) code for identifying a search space of acceptable molecular variants; (e) code for generating a random population of genomes from the search space of acceptable molecular variants by applying a selection operator; and (f) code for applying a set of operators comprising a crossover operator, a mutation operator, a fitness operator, and a repair operator on the random plurality of genomes to select the nvar set of optimized, diverse molecular variants.