Patent Document ID: 20150141419
Application ID: 14400203
Patent Flag: 0

Claim One:
1. A diarylo[a,g]quinolizidine compound of formula (I), an enantiomer, a diastereoisomer, a racemate, a mixture, a pharmaceutically acceptable salt, a crystalline hydrate or solvate thereof: wherein, rings A and D are each independently a benzene ring or a 5-12 membered aromatic heterocycle containing 1 to 4 heteroatoms selected from the group consisting of O, S and N, and the rings A and D are not simultaneously a benzene ring; R 5 and R 10 each independently represent 1 to 4 substituents selected from the group consisting of a hydrogen isotope, halogen, C1-C12 straight or branched alkyl unsubstituted or substituted with 1-3 halogens, C2-C12 straight or branched alkenyl or alkynyl unsubstituted or substituted with 1-3 halogens, C3-C6 cycloalkyl unsubstituted or substituted with 1-3 halogens, C1-C6 straight or branched alkyl substituted with C1-C6 alkoxy, C1-C6 straight or branched alkyl substituted with C3-C6 cycloalkyl, C1-C12 straight or branched alkyl substituted with 1-3 hydroxys, cyano, nitro, —OR 6 , —NR 6 R 7 , —SR 6 , —COOR 6 , —OR 9 OR 6 , —OR 9 COOR 6 , —OR 9 NR 6 R 7 , —R 9 COOR 6 , —R 9 CONR 6 R 7 , —R 9 OR 6 , —R 9 NR 6 R 7 , —N(R 6 )SO 2 R 7 , —R 8 , —R 9 R 8 , —OR 9 R 8 , —NHR 9 R 8 and —SO 2 NR 6 R 7 ; alternatively, any two adjacent R 5 s or adjacent R 10 s, together with the carbon atom or the heteroatom to which they are adjacent, form a 5-7 membered heterocycle containing 1 to 3 heteroatoms selected from the group consisting of N, O and S, which may be optionally substituted with one or more selected from the group consisting of hydrogen, a hydrogen isotope, halogen, C1-C6 straight or branched alkyl unsubstituted or substituted with 1-3 halogens, C1-C6 straight or branched alkoxy unsubstituted or substituted with 1-3 halogens, hydroxy, oxo (═O), and amino; R 1 , R 2 , R 3 and R 4 are each independently hydrogen, a hydrogen isotope, halogen, amino, hydroxy, oxo (═O), C1-C6 straight or branched alkyl unsubstituted or substituted with 1-3 halogens, C1-C6 straight or branched alkoxy unsubstituted or substituted with 1-3 halogens, C3-C6 cycloalkyl unsubstituted or substituted with 1-3 halogens, or C1-C6 straight or branched alkylcarbonyl unsubstituted or substituted with 1-3 halogens; R 8 is a 5-7 membered heterocyclyl containing 1-2 heteroatoms selected from the group consisting of N and O, which may be optionally substituted with one or more selected from the group consisting of hydrogen, a hydrogen isotope, halogen, —R 9 H, —R 9 OR 6 , and —R 9 NR 6 R 7 ; R 6 and R 7 are each independently hydrogen, a hydrogen isotope, halogen, C1-C6 straight or branched alkyl unsubstituted or substituted with 1-3 halogens or hydroxys, C3-C6 cycloalkyl unsubstituted or substituted with 1-3 halogens, C1-C6 acyl, C5-C12 aryl, unsubstituted or substituted 5- to 7-membered heterocyclyl containing 1 to 4 heteroatoms selected from the group consisting of O, S and N, or benzyl; the substituent of the substituted 5- to 7-membered heterocyclyl is one or more selected from the group consisting of halogen, C1-C6 straight or branched alkyl, C1-C6 straight or branched alkoxy, C3-C6 cycloalkyl, saturated or unsaturated C3-C7 heterocyclyl, cyano, nitro, amino, hydroxy, hydroxymethyl, methyl substituted with 1-3 fluorine atoms, methoxy substituted with 1-3 fluorine atoms, carboxyl, mercapto, and —R 9 OH; alternatively, R 6 and R 7 , together with the nitrogen atom to which they attached to, may form a ring; R 9 is C1-C6 straight or branched alkylene; the halogen is F, Cl, Br or I; and the chiral carbon atom in the compound of formula (I) may be in R- or S-configuration.