Patent Document ID: 20150371815
Application ID: 14743780
Patent Flag: 0

Claim One:
1. A method of accumulating an image of a specimen using a scanning-type microscope, comprising the following steps: providing a beam of radiation that is directed from a source through an illuminator so as to irradiate the specimen; providing a detector for detecting a flux of radiation emanating from the specimen in response to said irradiation; causing said beam to undergo scanning motion relative to a surface of the specimen, and recording an output of the detector as a function of scan position, in a first sampling session S 1 , gathering detector data from a first collection P 1 of sampling points distributed sparsely across the specimen; repeating this the procedure of gathering detector data from subsequent collections of sampling points so as to accumulate a set {P n } of such collections, gathered during an associated set {S n } of sampling sessions, each set with a cardinality N>1; assembling an image of the specimen by using the set {P n } as input to an integrative mathematical reconstruction procedure, wherein, as part of said assembly process, a mathematical registration correction is made to compensate for drift mismatches between different members of the set {P n }.