Patent Document ID: 20020142314
Application ID: 09904039
Patent Flag: 0

Claim One:
1. A method of analyzing a first nucleic sample comprising: providing said first nucleic acid sample; reproducibly reducing the complexity of said first nucleic acid sample to produce a second nucleic acid sample which may comprise a plurality of non-identical sequences whereby said second nucleic acid sample is obtainable by: fragmenting said first nucleic acid sample to produce fragments and ligating adaptor sequences to said fragments; fragmenting said first nucleic acid sample to produce fragments, denaturing said fragments, allowing some of said fragments to reanneal to form double stranded DNA sequences and removing said double stranded DNA sequences. amplification by arbitrarily primed PCR; hybridizing said first nucleic acid sample to an oligonucleotide probe bound to a solid support; hybridizing said first nucleic acid sequence to a mismatch binding protein; providing a nucleic acid array; hybridizing said second nucleic acid sample to said array; and analyzing a hybridization pattern resulting from said hybridization.