Patent Document ID: 20140296088
Application ID: 14115327
Patent Flag: 0

Claim One:
1. A multivariate cancer diagnostic method wherein said method determines the presence of both molecular markers and phenotypic morphological markers at the cellular level in a single cell or single sample containing a population of cells from a tissue, said method comprising: a. obtaining molecular marker data from a single sample from a subject comprising a single cell or population of cells from a tissue; b. obtaining quantitative cell morphology data from the same single cell or population of cells as used in step (a) and performing a multivariable analysis of said single sample to generate a multivariable data set comprising both quantitative cell morphology data from step (b) and molecular marker data from step (a); c. comparing the multivariable analysis data set obtained in step (b) with a reference multivariable analysis data set created by obtaining both molecular marker data and quantitative cell morphology data from cancer and non-cancer cell samples taken from individuals with known clinical outcome; and d. predicting a clinical outcome defined by specific combinations of cell morphologic markers and molecular markers statistically associated with cancer progression, occurrence, metastases or other determinant of clinical outcome seen in the reference multivariable analysis data set.