Patent Document ID: 20100023273
Application ID: 12574195
Patent Flag: 0

Claim One:
1. A method for the characterization of phenotypes by gene expression patterns and classification of samples based thereon, the method comprising the steps of: a) forming, from a plurality of first genes and first samples of a first phenotype, a first matrix of gene expression signals for the first phenotype, each gene expression signal corresponding to one of the first genes and one of the first samples; b) forming, from a plurality of selected genes and selected samples of a selected phenotype, a second matrix of gene expression signals for the selected phenotype, each gene expression signal corresponding to one of the selected genes and one of the selected samples, wherein each selected gene corresponds to one of the first genes; c) deriving a plurality of transformations, wherein each transformation renders uniform, within a selected interval, a distribution of transformed gene expression signals for one of the first genes, whereby each transformation corresponds to a selected gene; d) applying, for each of the selected genes, one of the transformations to the gene expression signals of a corresponding one of the selected genes of the second matrix; and e) defining at least one submatrix of the second matrix, wherein each transformed gene expression signal for each gene of the submatrix falls within a selected range.