Patent Document ID: 8778985
Application ID: 12223276
Patent Flag: 1

Claim One:
1. A method of inhibiting specific receptor-ligand interaction between Alzheimer's amyloid-β peptide (Aβ) and Receptor for Advanced Glycation Endproducts (RAGE) or RAGE activation, comprising administering an effective amount of one or more tertiary amides such that at least some Aβ/RAGE interaction is inhibited; wherein the tertiary amide(s) is selected from the group consisting of FPS1 (3-chloro-N-[2-cyclohexyl[[1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl]methyl]amino]-2-oxoethyl]-N-(3-ethoxypropyl)-2,2-dimethyl-(9Cl)-propanamide); FPS2 (3,5-dinitro-N-phenyl-N-[3-[(3,5,5-trimethyl-1-oxohexyl)amino]propyl]-(9Cl)-benzamide); FPS3 (4-chloro-N-[2-(1H-indo-3-yl)-ethyl]-3-nitro-N-(2-pentyl-3-phenyl-allyl-benzamide); N1A2B1 (N-benzyl-4-chloro-N-cyclohexyl-benzamide); N1A2B2 (N-benzyl-2,4-dichloro-N-cyclohexyl-benzamide); N2A1B1(4-chloro-N-(3-methyl-butyl)-N-phenethyl-benzamide); N2A2B2 (N-benzyl-2,4-dichloro-N-(3-methyl-butyl)-benzamide); N2A2B3 (N-benzyl-N-(3-methyl-butyl)-3,5-dinitro-benzamide); N2A2B4 (N-benzyl-N-(3-methyl-butyl)-3-nitro-benzamide); N2A2B5 (N-benzyl-4-chloro-N-(3-methyl-butyl)-3-nitro-benzamide); N3A2B2 (N-benzyl-2,4-dichloro-N-(1-ethyl-propyl)-benzamide); N3A2B3 (N-benzyl-N-(1-ethyl-propyl)-3,5-dinitro-benzamide); N3A2B5 (N-benzyl-4-chloro-N-(1-ethyl-propyl)-3-nitro-benzamide); N4A2B2 (N-benzyl-2,4-dichloro-N-(3-phenyl-propyl)-benzamide); and N4A2B5 (N-benzyl-4-chloro-3-nitro-N-(3-phenyl-propyl)-benzamide.