Patent Document ID: 20040157269
Application ID: 10716349
Patent Flag: 0

Claim One:
1. A screening system for determining the effect of a candidate compound on inflammatory response, said system comprising a test biological culture, assay reagents for measuring at least two parameters of ICAM-1, VCAM-1 E-selectin, P-selectin, IL-8, CD31, HLA-DR, eotaxin-3, MCP-1 MIG; and a data processor for analyzing the data from said biological culture in relation to at least one control biological culture of known activity, said biological culture comprising: endothelial cells, at least two factors of TNF-&agr;, IL-1, IL-4, histamine and IFN-&ggr; in amounts sufficient to induce an inflammatory state for said endothelial cells.