Patent Document ID: 8417661
Application ID: 13464104
Patent Flag: 1

Claim One:
1. An article comprising a non-transitory tangible machine-readable medium that stores a program, the program being executable by a machine to perform a method comprising: receiving a signature derived from a knowledge base of casual biological facts, where the signature is a collection of measured node entities and their expected directions of change with respect to a reference node; and scoring one or more data sets against the signature to compute an amplitude score, wherein the amplitude score is a weighted average of adjusted log-fold changes of measured node entities in the signature, where the adjustment applied to the log-fold changes is based on their expected direction of change; wherein the amplitude score is generated according to the following function: Strength = ∑ i ⁢ direction i × log 2 ⁡ ( FC i ) N where direction i and FC i represent expected direction of change and measured fold-change of an i th measured node entity, and N is a number of measured node entities in the signature.