Patent Document ID: 8296073
Application ID: 12309162
Patent Flag: 1

Claim One:
1. A method of prognosing an osteoporosis phenotype in a subject, which comprises: (I) determining in a biological sample from the subject the genotype of the subject at one or more positions of single nucleotide polymorphism, thereby obtaining outcomes for one or more single nucleotide polymorphism variables, and determining one or more clinical variables for the subject; and (II) using the variable outcomes obtained in (I) to prognose the phenotype; wherein: (a) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained in step (I) comprise the general BSTEP model variables in FIG. 9 ; and/or (b) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained in step (I) comprise the general FSTEP model variables in FIG. 9 ; and/or (c) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained In step (I) comprise the male BSTEP model variables in FIG. 9 ; and/or (d) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained in step (I) comprise the male FSTEP model variables In FIG. 9 ; and/or (e) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained in step (I) comprise the female BSTEP model variables in FIG. 9 ; and/or (f) the osteoporosis phenotype is a presence of one or more non-traumatic fractures in the wrist, hip or spine (WSHfractures) and the variables for which outcomes are obtained in step (I) comprise the female FSTEP model variables in FIG. 9 ; and/or (g) the osteoporosis phenotype is presence of one or more non-traumatic vertebral fractures and the variables for which outcomes are obtained in step (I) comprise the male vertebral fractures variables or the female vertebral fractures variables in Table 5; and wherein (i) an outcome for an SNP variable is the identity of the nucleotide in the genomic DNA of the subject at the position of the single nucleotide polymorphism; (ii) an outcome for the clinical variable AGE is age of the subject in years; (iii) an outcome for the clinical variable MENOPAUSE AGE is the age in years of the onset of menopause in a female subject; (iv) an outcome for the clinical variable MENARCHE AGE is the age in years of the onset of menarche in a female subject; (v) an outcome for the clinical variable BMI is the body mass index of the subject.