Patent Document ID: 9719090
Application ID: 14654998
Patent Flag: 1

Claim One:
1. A method of trans-differentiating a terminally differentiated target cell to a neuron comprising the step of introducing: (a) a LIM homeobox transcription factor (Lmx) agent that is LIM homeobox transcription factor, or a nucleic acid encoding the same, (b) a nuclear receptor subfamily 4 (NR4) agent that is a nuclear receptor subfamily 4 factor, or a nucleic acid encoding the same, (c) a c-Fos agent that is a c-Fos, or a nucleic acid encoding the same, and (d) an Early B Cell Factor (EBF) agent that is an EBF, or a nucleic acid encoding the same into the target cell under conditions suitable to cause the target cell to trans-differentiate into a neuron.