Patent Document ID: 9594075
Application ID: 14692242
Patent Flag: 1

Claim One:
1. A method for determining an effect of a compound on a neurological condition, the method comprising: presenting a compound selected for treating a neurological condition to a cell sample exhibiting a genotype associated with the neurological condition, the cell sample comprising a plurality of neurons, wherein at least one of the plurality of neurons expresses an optical reporter of membrane electrical potential; optically stimulating an optogenetic actuator in the sample following presentation of the compound, wherein the optogenetic actuator is a light gated ion channel; generating an optical signal in response to the optical stimulation of the light gated ion channel using the optical reporter; receiving, via a microscopy system, the optical signal generated by the optical reporter; analyzing the optical signal generated by the optical reporter with respect to a control signal obtained from a control cell sample not exhibiting a genotype associated with the neurological condition; and identifying the compound as a candidate for treatment of the neurological condition based on the analysis of said optical signal with respect to the control signal.