Patent Document ID: 8067183
Application ID: 11827425
Patent Flag: 1

Claim One:
1. A method for determining if one or more candidate compounds is a potential therapeutic for a neurodegenerative disease, comprising: (a) growing fibroblasts from a human donor having the disease, (b) contacting the fibroblasts with one or more candidate compounds, and (c) measuring the amount of a protein, selected from the group consisting of: a protein with apparent molecular weight of 89,300 Daltons and an apparent pI of 4.53 a protein with apparent molecular weight of 33,100 Daltons and an apparent pI of 4.95 a protein with apparent molecular weight of 55,100 Daltons and an apparent pI of 5.03 a protein with apparent molecular weight of 94,200 Daltons and an apparent pI of 5.10 a protein with apparent molecular weight of 130,700 Daltons and an apparent pI of 4.92 a protein with apparent molecular weight of 130,400 Daltons and an apparent pI of 4.97 a protein with apparent molecular weight of 149,000 Daltons and an apparent pI of 4.97 a protein with apparent molecular weight of 149,000 Daltons and an apparent pI of 5.01 a protein with apparent molecular weight of 150,600 Daltons and an apparent pI of 5.11 a protein with apparent molecular weight of 53,000 Daltons and an apparent pI of 5.35 a protein with apparent molecular weight of 145,400 Daltons and an apparent pI of 5.37 a protein with apparent molecular weight of 37,000 Daltons and an apparent pI of 5.71 a protein with apparent molecular weight of 47,600 Daltons and an apparent pI of 5.46 a protein with apparent molecular weight of 63,700 Daltons and an apparent pI of 5.42 a protein with apparent molecular weight of 71,400 Daltons and an apparent pI of 5.57 a protein with apparent molecular weight of 73,400 Daltons and an apparent pI of 5.48 a protein with apparent molecular weight of 67,900 Daltons and an apparent pI of 5.92 a protein with apparent molecular weight of 67,700 Daltons and an apparent pI of 5.84 a protein with apparent molecular weight of 109,500 Daltons and an apparent pI of 5.77 a protein with apparent molecular weight of 29,000 Daltons and an apparent pI of 6.42 a protein with apparent molecular weight of 46,300 Daltons and an apparent pI of 6.48 a protein with apparent molecular weight of 80,300 Daltons and an apparent pI of 6.30 a protein with apparent molecular weight of 138,200 Daltons and an apparent pI of 6.31 a protein with apparent molecular weight of 159,500 Daltons and an apparent pI of 6.25 a protein with apparent molecular weight of 192,800 Daltons and an apparent pI of 6.26 in the fibroblasts that have been contacted with the candidate compound(s), wherein a decrease in the amount of the protein measured in step (c) as compared to the amount of the protein present in control fibroblasts indicates that the one or more compounds is a potential therapeutic for the disease, and wherein the neurodegenerative disease is Charcot-Marie-Tooth disease.