Patent Document ID: 20060025461
Application ID: 11232011
Patent Flag: 0

Claim One:
1. A pharmaceutical composition for glycine transporter inhibitor which comprises a triazole derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as the effective ingredient: (in the formula, the symbols represent the following meanings; Ring A: (1) an aromatic carbon ring which may be substituted, (2) an aliphatic carbon ring which may be substituted and may be condensed with benzene ring or hetero ring, or (3) a 6-membered hetero ring which may be substituted and contain one nitrogen atom as a ring atom and may contain one oxygen atom or sulfur atom as a hetero atom other than the nitrogen atom and may be condensed with benzene ring; Ring B or D may be the same or different and each represents aromatic carbon ring which may be substituted, an aliphatic carbon atom which may be substituted, or a hetero ring which may be substituted; R: H, halogeno-lower alkyl, aryl which may be substituted, hetero ring which may be substituted, cycloalkyl which may be substituted, or -[Alk1]m-X-[Alk2]n-Y—R 1 wherein R 1 : H, OH, cyano, aryl which may be substituted, hetero ring which may be substituted, cycloalkyl which may be substituted, or lower alkoxyl; X: bond, oxygen atom, S(O)q, or —N(R 2 )—; Y: bond, —C(O)—, —C(O)—N(R 3 )—, -Z 1 -Alk3-, or —N(R 3 )-Alk3-C(O)—, with the proviso that R 1 represent other than OH and lower alkoxy, when Y is bond; Alk1 or Alk2 may be the same or different and each represents lower alkylene, lower alkenylene or lower alkynylene; and m or n may be the same or different and each represents 0 or 1 or m+n=1, provided that X represents bond; Z 1 : S(O)q, —N(R 3 )—, —C(O)— or —C(O)—N(R 3 )—; Alk3: lower alkylene; R 2 or R 3 : the same or different from each other and each represents H or lower alkyl; q: may be 0, 1 or 2)