Patent Document ID: 7754941
Application ID: 11729242
Patent Flag: 1

Claim One:
1. A method of testing for a small organic compound that modulates neuronal demyelination in the nervous system, comprising: (a) administering said small organic compound to a transgenic mouse animal, whose genome comprises: (i) a stably integrated transgenic nucleotide sequence encoding interferon-gamma (IFN-γ) operably linked to an inducible promoter; and (ii) a heterozygous knock-out of the endogenous pancreatic endoplasmic reticulum (ER) kinase gene (PERK), wherein upon expression of said IFN-γ said transgenic mouse exhibits a greater degree of demyelination relative to a transgenic animal-mouse having a stably integrated transgenic nucleotide sequence encoding IFN-γ as in (i), but lacking said heterozygous knock-out of the PERK gene; (b) determining whether said small organic compound effectively modulates neuronal demyelination in the nervous system.