Patent Document ID: 20150143560
Application ID: 14541252
Patent Flag: 0

Claim One:
1. A non-human animal model of epilepsy, into which an isolated protein consisting of an amino acid sequence which comprises one or more mutations selected from the group consisting of substitution of tyrosine (Y) for cysteine (C) at position 1483, substitution of arginine (R) for cysteine (C) at position 1483, substitution of lysine (K) for glutamic acid (E) at position 2419, substitution of glycine (G) for glutamic acid (E) at position 2419, substitution of proline (P) for leucine (L) at position 2427, and substitution of glutamine (Q) for leucine (L) at position 2427 in an amino acid sequence of SEQ ID NO. 2; or an isolated gene consisting of a nucleotide sequence which comprises one or more mutations selected from the group consisting of substitution of adenine (A) for guanine (G) at position 4448, substitution of cytosine (C) for thymine (T) at position 4447, substitution of adenine (A) for guanine (G) at position 7255, substitution of guanine (G) for adenine (A) at position 7256, substitution of cytosine (C) for thymine (T) at position 7280, and substitution of adenine (A) for thymine (T) at position 7280 in a nucleotide sequence of SEQ ID NO. 1 is introduced.