Patent Document ID: 20160017422
Application ID: 14768578
Patent Flag: 0

Claim One:
1. A method for detecting a biomarker gene or its splice variant for evaluating the competence of a mammalian oocyte to lead to childbirth, to implantation, to form a pre-implantation blastocyst or embryo, and/or to lead to fertilization; said method comprising: using live birth and embryo development as a selection endpoint for the oocyte to be used; making exon level analysis of gene expression in a sample comprising at least one granulosa or cumulus cell associated with the oocyte; making intra-patient based comparison of said exon level analysis of gene expression; and consider only p-values <0.05 in a paired t-test as significant for a biomarker gene in being for evaluating the competence of a mammalian oocyte to lead to childbirth, to implantation, to form a pre-implantation blastocyst or embryo, and/or to lead to fertilization.