Patent Document ID: 20040214818
Application ID: 10848386
Patent Flag: 0

Claim One:
1. A pharmaceutical composition for glycine transporter inhibitor which comprises a triazole derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as the effective ingredient: 210 Ring A: (1) an aromatic carbon ring which may be substituted, (2) an aliphatic carbon ring which may be substituted and may be condensed with benzene ring or hetero ring, (3) a 5-membered hetero ring which may be substituted and contain one or two nitrogen atoms as the hetero atoms composing the ring and may contain one oxygen atom or sulfur atom as a hetero atom other than the nitrogen atoms and may be condensed with benzene ring or (4) a 6-membered hetero ring which may be substituted and contain one nitrogen atom as a ring atom and may contain one oxygen atom or sulfur atom as a hetero atom other than the nitrogen atom and may be condensed with benzene ring; Ring B or D may be the same or different and each represents aromatic carbon ring which may be substituted, an aliphatic carbon atom which may be substituted, or a hetero ring which may be substituted. R: H, halogeno-lower alkyl, aryl which may be substituted, hetero ring which may be substituted, cycloalkyl which may be substituted, or -&lsqb;Alk1&rsqb;m-X-&lsqb;Alk2&rsqb;n-Y—R 1 wherein R 1 : H, OH, cyano, aryl which may be substituted, hetero ring which may be substituted, cycloalkyl which may be substituted, or lower alkoxyl; X: bond, oxygen atom, S(O)q, or —N(R 2 )—; Y: bond, —C(O)—, —C(O)—N(R 3 )—, —Z 1 -Alk3-, or —N(R 3 )-Alk3-C(O)—, with the provisothat R 1 represent other than OH and lower alkoxy, when Y is bond; Alk1 or Alk2 may be the same or different and each represents lower alkylene, lower alkenylene or lower alkynylene; and m or n may be the same or different and each represents 0 or 1 or m&plus;n&equals;1, provided that X represents bond; Z 1 : S(O) q, —N(R 3 )—, —C(O)— or —C(O)—N(R 3 )—; Alk3: lower alkylene; R 2 or R 3 : the same or different from each other and each represents H or lower alkyl; q: 0, 1 or 2 may be)