Patent Document ID: 10149618
Application ID: 14656117
Patent Flag: 1

Claim One:
1. A method for localization of implanted depth electrodes (DE) in a brain of a subject, said method comprising: performing a first anatomical scan of said brain; generating a three-dimensional (3D) model of said brain using said anatomical scan, said 3D model comprising cortical topological features; implanting at least one DE into said brain; performing a second anatomical scan of said brain after said implanting, said second anatomical scan elucidating a position and orientation of said at least one DE relative to said brain; aligning said first and second anatomical scans; visually projecting said position and orientation of said at least one DE on said 3D model using aligning of said first and second anatomical scans; further comprising implanting an array of DEs into said brain prior to said second anatomical scan, wherein said at least one DE comprises a member of said array of DEs; and recursively localizing said array of DEs on said 3D model by contouring said array of DEs to said cortical topological features in said 3D model relative to said at least one DE, said array of DEs comprising a grid which conforms to a pial surface in situ with said array of DEs placed at known positions relative to said at least one DE, wherein said contouring of said array of DEs to said cortical topological features comprises contouring said array of DEs to a smoothed 3D model which omits sulcal anatomy and which is aligned with said 3D model.