Patent Document ID: 7813881
Application ID: 11221166
Patent Flag: 1

Claim One:
1. A method for quantifying domains within a punctate distribution comprising the steps of: acquiring at least one digital image of a punctate distribution, wherein the at least one digital image is a fluorescence photomicrographic image of the nucleus of a eukaryotic cell; performing image segmentation on the at least one digital image to produce a segmented image of the punctate distribution; identifying domains within the punctate distribution of the segmented image; and computing at least twenty-five organizational parameters of the domains within the punctate distribution of the segmented image wherein the at least 25 organizational parameters comprise the number of domains, mean domain size, median domain size, standard deviation of domain size, variance of domain size, skewness of domain size, kurtosis of domain size, coefficient of variation of domain size; index of dispersion of domain size; mean nearest neighbor distance, median nearest neighbor distance, standard deviation of nearest neighbor distance, variance of nearest neighbor distance, skewness of nearest neighbor distance, kurtosis of nearest neighbor distance, coefficient of variation of nearest neighbor distance; index of dispersion of nearest neighbor distance, domain density, Re, Ro/Re, Ve, Vo/Ve, Rp, Rd, or Rd/Rp.