Patent Document ID: 20150037811
Application ID: 14449672
Patent Flag: 0

Claim One:
1. A fluorescence sensing compound for detecting and visualizing a synaptic release of one or more primary amine neurotransmitters, the fluorescence sensing compound having the following formula: wherein: the -GH group at the C7-position is an electron-donor that confers an internal charge transfer mechanism to the compound upon deprotonation, which occurs at a pH that is greater than 5 and less than 7.4, and wherein the -GH group is selected from the group consisting of sulfamidyl, sulfonamidyl, hydroxyl, amidyl, arylamino, and alkylamino; the aldehyde group at the C3-position is an electron-acceptor and enables iminium-ion formation with said primary neurotransmitter(s); R 3 is selected from the group consisting of hydrogen, alkyl, alkylene, aryl, and cycloakyl; and the fluorescence sensing compound has a pK a is in a range of about 6.0 to about 7.4.