Patent Document ID: 8489531
Application ID: 13019585
Patent Flag: 1

Claim One:
1. A computer implemented method for identifying co-regulation patterns within gene expression data comprising gene expression levels, the method comprising: (a) inputting the data into a computer system having a memory and a processor for executing a clustering algorithm; (b) selecting a clustering algorithm based on a dissimilarity measure between pairs of principal components of the gene expression levels; (c) randomly assigning class labels to the gene expression levels; (d) defining a plurality of clusters of gene expression levels within each labeled class; (e) measuring dissimilarity between each cluster of gene expression levels by measuring a residual of a fit of one cluster onto another cluster, wherein the residual fit comprises using a fit that is invariant with respect to affine transformations, wherein the affine transformations comprise a combination of translation, scaling and rotation; (f) reassigning gene expression levels to the labeled class with the most similar cluster; (g) repeating steps (d) through (f) until assignment of gene expression levels to the labeled classes remains constant; and (h) displaying a graph showing the gene expression levels clustered into the labeled classes, wherein the labeled classes correspond to co-regulation activity.