Patent Document ID: 9447451
Application ID: 14260082
Patent Flag: 1

Claim One:
1. A method for performing epigenetic analysis of native chromatin in a channel, comprising: (a) flowing the native chromatin through an interrogation volume in said channel that is illuminated with a beam of light, said interrogation volume being defined by walls of a submicrometer channel region that are separated by a width of less than about 1 μm of said channel and said beam of light, wherein said native chromatin is labeled with a plurality of labels, at least one of which is specifically complexed with an epigenetic marker on said native chromatin, and at least one other label is complexed with a protein and/or nucleotide of said native chromatin (b) simultaneously detecting the at least one label and the at least one other label within the interrogation volume and (c) analyzing said detection of the at least one label and the at least one other label, thereby performing said epigenetic analysis.