Patent Document ID: 4833148
Application ID: 07036500
Patent Flag: 1

Claim One:
1. A method to inhibit neuronal degeneration in mammals induced by anoxia, hypoxia or ischemia, which method comprises treating a mammal susceptible to neurotoxic injury with an effective amount of a thiobarbiturate compound having at least one ring atom substituted with an alkenyl or alkynyl type moiety, said thiobarbiturate compound further characterized in having broad spectrum activity as an antagonist at major neuronal excitatory amino acid receptor sites to inhibit excitotoxic actions at said major receptor sites, wherein said thiobarbiturate compound is of the formula ##STR3## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 groups is independently selected from hydrido, linear or branched alkyl groups of one to twenty carbon atoms, linear or branched alkenyl groups of two to twenty carbon atoms, linear or branched alkynyl groups of two to twenty carbon atoms, phenyl, benzyl, any one of which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 groups may be optionally substituted by oxo, hydroxyl, alkoxy, thio, amino, halo, nitrile, mercapto, carboxyl, carboxamido and thiocarboxamido; and the tautomers, isomers and pharmacologically active salts thereof; with the proviso that at least one of said R.sup.1, R.sup.2, R.sup.3 and R.sup.4 groups is an alkenyl or alkynyl group or is a group substituted with at least one alkenyl or alkynyl moiety.