Patent Document ID: 9405996
Application ID: 12562454
Patent Flag: 1

Claim One:
1. A method for generating a patient specific four-dimensional (4D) multi-scale anatomical heart model having morphological, dynamics, and hemodynamics model components, comprising: generating a patient specific 4D geometric model estimated from a sequence of volumetric cardiac imaging data of a patient generated using at least one medical imaging modality by: receiving at least one sequence of volumetric cardiac imaging data of the patient generated using the at least one medical imaging modality, estimating individual 4D models for a plurality of heart components in said at least one sequence of volumetric cardiac imaging data, the plurality of heart components including a plurality of heart chambers and a plurality of heart valves, and generating a patient specific 4D geometrical heart model by integrating the individual 4D models for each of said plurality of heart components; generating a patient specific 4D computational model based at least on measurements of volumes of the heart chambers and measurements of opening areas of the heart valves in the 4D geometric model by: computing the measurements of the volumes of the heart chambers and the measurements of the opening areas of the heart valves in the 4D geometric model over a full cardiac cycle, wherein the measurements of the opening areas of the heart valves are measured directly from the heart valves in the 4D geometric model, and estimating blood quantity, pressure, and velocity, for each of the heart chambers based on the measurements of the volumes of the heart chambers and the measurements of the opening areas of the heart valves in the 4D geometric model; and generating a patient specific biomechanical model based on Fluid Structure Interaction (FSI) simulations using the 4D computational model.