Patent Document ID: 8945919
Application ID: 12733108
Patent Flag: 1

Claim One:
1. A method for promoting survival of neural cells in a host by provision of one or more trophic factors, wherein the method comprises transplanting bone marrow-derived neural regenerating cells at or near a site of neural degeneration in the host, wherein the neural regenerating cells are obtained by a process comprising the steps of: (a) providing a culture of marrow adherent stromal cells; (b) contacting the cell culture of step (a) with a polynucleotide comprising sequences encoding a Notch intracellular domain (NICD), wherein the NICD consists of amino acids 1703-2504 of the Notch-1 protein; (c) selecting cells that comprise the polynucleotide of step (b); and (d) further culturing the selected cells of step (c) in the absence of selection; and further wherein the neural regenerating cells provide trophic factors that promote survival of the neural cells in the host.