Patent Document ID: 7636636
Application ID: 10269723
Patent Flag: 1

Claim One:
1. A method of detecting single copy number variation in a target spot of a genomic microarray comprising: acquiring an image of said microarray including said target spot; processing the image to correct for chip misalignment; processing the image to correct for background noise; analyzing the image to identify a target patch; analyzing the image to edit debris; analyzing the image to correct for ratio bias; detecting single copy number variation in the target spot by an objective statistical analysis; wherein the genomic microarray includes a test genomic material marked with receptors having a first wavelength and a reference genomic material marked with receptors having a second wavelength, the test and reference genomic materials forming the target spot by a hybridization process; further comprising measuring a fluorescent signal intensity of the target spot from the test genomic material and the reference genomic material, wherein the fluorescent signal intensity of the first wavelength is proportional to a copy number of the test genomic material and the fluorescent signal intensity of the second wavelength is proportional to a copy number of the reference genomic material; obtaining an image of a theoretical set of patches; and, cross-correlating the image of the theoretical set of patches to the image of the microarray.