Patent Document ID: 9856537
Application ID: 15274492
Patent Flag: 1

Claim One:
1. A method for processing a thyroid tissue sample of a subject, comprising: (a) obtaining said thyroid tissue sample of said subject, which thyroid tissue sample comprises gene expression products; (b) subjecting a first portion of said thyroid tissue sample to cytological testing that identifies said thyroid tissue sample as ambiguous or suspicious; (c) upon identifying said thyroid tissue sample as ambiguous or suspicious, assaying by sequencing, array hybridization, or nucleic acid amplification said gene expression products of a second portion of said thyroid tissue sample; (d) determining differential gene expression product levels of said gene expression products with respect to one or more control samples, to yield data corresponding to said differential gene expression product levels; (e) inputting said data to a trained algorithm to generate a classification of said thyroid tissue sample as positive or negative for a thyroid condition at an accuracy of at least about 90%, wherein a plurality of technical factor variables is selectively removed from said data and normalized prior to or during classification; and (f) electronically outputting a report that identifies said classification of said thyroid tissue sample as positive or negative for said thyroid condition.