Patent Document ID: 8420611
Application ID: 11572391
Patent Flag: 1

Claim One:
1. A method of prolonging the survival of a mammal that has a brain tumor, comprising: providing a quantity of a first viral vector encoding thymidine kinase (TK) operably linked to a first promoter; providing a quantity of a second viral vector encoding Fms-like tyrosine kinase 3 ligand (Flt3L) operably linked to a second promoter; co-administering a therapeutically effective amount of the quantity of the first viral vector encoding TK operably linked to the first promoter and the quantity of the second viral vector encoding Flt3L operably linked to the second promoter directly into the brain tumor in the mammal; and administering a therapeutically effective quantity of systemic ganciclovir to the mammal, wherein the TK and Flt3L are expressed in the brain tumor, wherein the brain tumor is macroscopic at the time of initial treatment, and wherein survival of the mammal is prolonged for at least six months.