Patent Document ID: 7806854
Application ID: 11914146
Patent Flag: 1

Claim One:
1. A system for automatic control of blood glucose level of a subject, comprising: a glucose sensor operative to continually sense a glucose level of the subject and generate a corresponding glucose level signal; a delivery device operative to deliver doses of insulin to the subject in response to an insulin dose control signal; and a controller operative to generate the insulin dose control signal as a function of the weight of the subject and time-varying glucose levels of the subject as represented by the glucose level signal over time, the controller employing a control algorithm including: generating the insulin dose control signal based on (a) the glucose level signal, and (b) accumulation of insulin in the subject due to finite rate of utilization, wherein the controller employs a model-predictive control algorithm by which the insulin dose control signal is generated as a value optimizing an objective function with objectives of (a) a weighted integration of a difference between a predicted glucose level signal and a setpoint signal over a time horizon, and (b) a weighted integration of the insulin dose control signal over the time horizon.