Patent Document ID: 8073630
Application ID: 11846406
Patent Flag: 1

Claim One:
1. A method for determining clinical responsiveness to antifolate therapy in a human subject afflicted with, or at risk of developing, arthritis comprising detecting the presence in a biological sample from the subject of a 1958G>A polymorphism in the methylenetetrahydrofolate dehydrogenase (MTHFD1) gene, a 34C>T polymorphism in the adenosine monophosphate deaminase (AMPD1) gene, a 347 C>G polymorphism in the aminoimidazole carboxamide ribonucleotide transformylase (ATIC) gene; and a 94 C>A polymorphism in the inosine triphosphate pyrophosphatase (ITPA) gene, wherein the presence of the polymorphisms in the biological sample is indicative of clinical responsiveness to the antifolate therapy.