Patent Document ID: 20140128762
Application ID: 14067888
Patent Flag: 0

Claim One:
1. A method of epileptogenic source localization for obtaining spatial and temporal relationships among epileptogenic zones, comprising: (a) an Independent Component Analysis (ICA) based seizure detection method, wherein said seizure detection method comprises the steps of: (i) preprocessing ECoG data obtained using a plurality of channels from a subject's brain, wherein said preprocessing removes the mean of said ECoG data and achieves whitening of said ECoG data; (ii) using said preprocessing to uncover Independent Components (ICs) and to estimate a mixing matrix; and (iii) performing seizure detection on each of said uncovered ICs to identify a seizure, wherein said step (iii) comprises the steps of: (j) applying a fast Fourier transform (FFT) function to each of said ICs to obtain a frequency spectrum of each of said ICs; (jj) calculating a power spectrum for each of said ICs in a frequency band; and (jjj) based on one or more criteria detecting said seizure for each of said ICs and if said seizure is detected calculating: (k) a reduced mixing matrix from said mixing matrix; and (kk) a seizure IC matrix; and (iv) performing a back projection method comprising the steps of: (p) calculating the product of said reduced mixing matrix and said seizure IC matrix; and (pp) calculating power strength data for each of said plurality of channels; and (b) a steepest descent-based source localization method for determining temporal relationships among said detected seizures, (c) wherein both said seizure detection method steps and said source localization method steps are coded in a computer language and said coded computer language is stored on a computer-readable medium which is executable by a computing device.