Patent Document ID: 20020106709
Application ID: 09927773
Patent Flag: 0

Claim One:
1. A method for predicting a hypoglycemic event in a subject, said method comprising, determining (i) a threshold glucose value that corresponds to said hypoglycemic event, and (ii) at least one threshold parameter value that is correlated with said hypoglycemic event, wherein the parameter is either skin conductance readings or temperature readings, obtaining a series of glucose measurement values at selected time intervals using a method comprising extracting a sample comprising glucose from the subject using a transdermal sampling system that is in operative contact with a skin or mucosal surface of said subject; obtaining a raw signal from the extracted glucose, wherein said raw signal is specifically related to glucose amount or concentration in the subject; correlating the raw signal with a glucose measurement value indicative of the amount or concentration of glucose present in the subject at the time of extraction; repeating said extracting, obtaining, and correlating to provide a series of measurement values at selected time intervals, wherein the sampling system is maintained in operative contact with the skin or mucosal surface of said subject during said extracting, obtaining, and correlating to provide for frequent glucose measurements; predicting a measurement value at a further time interval subsequent to said series of measurement values, said further time interval represented as n&plus;1; and comparing said predicted measurement value to said threshold glucose value, wherein a measurement value lower than the threshold value is designated to be hypoglycemic; measuring a parameter value or trend of parameter values concurrently, simultaneously, or sequentially with said obtaining of the series of measurement values, wherein the parameter value or trend of parameter values is reflective of either skin conductance readings or temperature readings of the subject, and comparing said parameter value or trend of parameter values with said threshold parameter value to determine whether said parameter value or trend of parameter values indicates a hypoglycemic event; and predicting a hypoglycemic event in said subject when both (i) comparing said predicted measurement value to said threshold glucose value indicates a hypoglycemic event at time interval n&plus;1, and (ii) comparing said parameter with said threshold parameter value indicates a hypoglycemic event.