Patent Document ID: 7751883
Application ID: 11380048
Patent Flag: 1

Claim One:
1. A medical system configured to promote coronary angiogenesis in a patient, the system comprising: an implantable medical electrical pacing lead including at least one electrode, the at least one electrode being adapted to deliver cardiac pacing stimuli, when the pacing lead is implanted in the patient; a first fluid reservoir and a plurality of boluses of heparin, the first fluid reservoir containing the plurality of boluses of heparin; a first pump being coupled to the first fluid reservoir and being adapted to pump each bolus of heparin from the first reservoir; a second fluid reservoir and a plurality of boluses of an adenosine-modulating drug, the second fluid reservoir containing the plurality of boluses of the adenosine-modulating drug; a second pump being coupled to the second fluid reservoir and being adapted to pump each bolus of the adenosine-modulating drug from the second reservoir; a delivery tube coupled to the first reservoir and to the second reservoir, the delivery tube being adapted to deliver the boluses of the heparin and the adenosine-modulating drug into a venous system of the patient; and a microcomputer unit coupled to the pacing lead and to each of the first and second pumps, the microcomputer unit being programmed with instructions to control the lead and the pumps in order to execute a method for delivering angiogenic therapy according to the following steps: delivering a bolus of heparin through the delivery tube and into the venous system of the patient, the bolus of heparin being pumped, by the first pump, from the plurality of boluses of heparin contained in the first fluid reservoir; delivering the cardiac pacing stimuli via the at least one electrode of the implanted pacing lead for a predetermined period of time and at a rate that generally provokes myocardial ischemia in the patient, after delivering of the bolus of heparin; and delivering a bolus of the adenosine-modulating drug through the implanted delivery tube, and into the venous system of the patient, after delivering the pacing stimuli, the bolus of the adenosine-modulating drug being pumped, by the second pump, from the plurality of boluses of the adenosine-modulating drug contained in the second fluid reservoir.