Patent Document ID: 20030191311
Application ID: 10364596
Patent Flag: 0

Claim One:
1. A compound of formula 36 A is phenyl, pyridin-2-yl, pyridin-3-yl, or piperidin-1-yl; R 1 and R 2 are each independently selected from the group consisting of hydrogen, halogen, lower alkyl, cycloalkyl, lower alkenyl, trifluoromethyl, —O-trifluoromethyl, —S-trifluoromethyl, S-lower alkyl, lower alkoxy, —CHF 2, —C(lower alkyl)F 2, —OCHF 2, phenyl, nitro, benzyloxy, hydroxy and amino, or alternatively, R 1 and R 2 together with the carbon atoms to which they are attached in any adjacent positions from a group selected from —CH&boxH;CH—CH&boxH;CH—, —CH&boxH;CH—CH&boxH;N—, —(CH 2 ) 3 —, —O—CH 2 —O—, —O—CF 2 —O—, —CH 2 —O—CH 2 — and —CH 2 CH 2 —O—; R 3 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, phenyl, S-lower alkyl, amino, lower alkyl-amino, —NHC(O)-lower alkyl and hydroxy-lower alkyl; R 4 and R 5 are each independently selected from hydrogen and lower alkyl, or alternatively, R 4 and R 5 together with the carbon atoms to which they are attached form the group —(CH 2 ) 4 —; R 6 and R 6′ are each independently selected from hydrogen and lower alkyl; X is —N< or 37 Y is &boxH;N—, —NH—, —N&boxH;CH— or —CH&boxH;; Z is —CR 7 &boxH;—N&boxH;, —NR 7 —, —N&boxH;CR 7 —, &boxH;CH—N&boxH;C(R 7 )— or &boxH;N—CH&boxH;CH—; R 7 is hydrogen, —CH 2 OH or lower alkyl; n is 0, 1 or 2; m is 0 or 1; and the dotted line may be 1, 2 or 3 bonds; with the proviso that X, Y and Z together form a phenyl or pyridyl ring; and pharmaceutically acceptable acid addition salts thereof.