Patent Document ID: 8460921
Application ID: 12441703
Patent Flag: 1

Claim One:
1. A neuronal network analysis plate comprising: a plurality of recording wells organized into a plurality of recording rows, wherein each recording well contains a neural cell network and a plurality of electrodes for recording action potential signals from the neural cell network; a plurality of amplifying wells organized into a plurality of amplifying rows, wherein each amplifying well contains one or more miniaturized, insertion VLSI preamplifiers inserted fully into each amplifying well for amplifying recording signals from the recording wells, wherein the plurality of recording rows and the plurality of amplifying rows are alternating such that each recording well is adjacent to a corresponding amplifying well, wherein the miniaturized, insertion VLSI preamplifiers are located within about 10 to about 20 mm of the plurality of electrodes, wherein the miniaturized, insertion VLSI preamplifiers are capable of fitting within a cylindrical well about 6 mm in diameter and about 10 mm tall, and wherein the miniaturized, insertion VLSI preamplifiers comprise a plurality of contact pads for connection to the plurality of electrodes; a plurality of interconnects, wherein each interconnect connects the electrodes of a recording well with the plurality of contact pads of the miniaturized, insertion VLSI preamplifiers of a corresponding amplifying well; and secondary amplification equipment connected to the miniaturized, insertion VLSI preamplifiers.