Title: Grounding AI Explanations in Experience: A Reflective Cognitive Architecture for Clinical Decision Support
Primary area: applications to computer vision, audio, language, and other modalities
Keywords: Disease Prediction, Medicine, LLM-based Agent, Explainability

Abstract: Effective disease prediction in modern healthcare demands the twin goals of high accuracy and transparent, clinically meaningful explanations. Existing machine learning and large language model (LLM) based approaches often struggle to balance these goals. Many models yield accurate but unclear statistical outputs, while others generate fluent but statistically unsupported narratives, often undermining both the validity of the explanation and the predictive accuracy itself. This shortcoming comes from a shallow interaction with the data, preventing the development of a deep, detailed understanding similar to a human expert's. We argue that high accuracy and high-quality explanations are not separate objectives but are mutually reinforcing outcomes of a model that develops a deep, direct understanding of the data. To achieve this, we propose the Reflective Cognitive Architecture (RCA), a novel framework that coordinates multiple LLMs to learn from direct experience. RCA features an iterative rule refinement mechanism that improves its logic from prediction errors and a distribution-aware rules check mechanism that bases its reasoning in the dataset's global statistics. By using predictive accuracy as a signal to drive deeper comprehension, RCA builds a strong internal model of the data. We evaluated RCA on one private and two public datasets against 22 baselines. The results demonstrate that RCA not only achieves state-of-the-art accuracy and robustness with a relative improvement of up to 40\% over the baseline but, more importantly, leverages this deep understanding to excel in generating explanations that are clear, logical, evidence-based, and balanced, highlighting its potential for creating genuinely trustworthy clinical decision support systems.