Title: CountsDiff: A diffusion model on the natural numbers for generation and imputation of count-based data
Primary area: generative models
Keywords: generative models, diffusion models, data imputation, computational genomics, discrete diffusion, blackout diffusion, birth death processes

Abstract: Diffusion models have excelled at generative tasks for both continuous and token-based domains, but their application to discrete ordinal data remains underdeveloped. We present \emph{CountsDiff}, a diffusion framework designed to natively model distributions on the natural numbers. CountsDiff builds on the Blackout diffusion framework by simplifying its formulation through a direct parameterization in terms of a survival probability schedule and an explicit loss weighting. This introduces flexibility through design parameters with direct analogues in existing diffusion modeling frameworks.
Beyond this reparameterization, CountsDiff introduces features from modern diffusion models, previously absent in counts-based domains, including continuous-time training, classifier-free guidance, and churn/remasking reverse dynamics that allow non-monotone reverse trajectories. 
We propose an initial instantiation of CountsDiff and validate it on natural image datasets (CIFAR-10, CelebA), demonstrating that the framework scales to complex, high-dimensional data domains. We then highlight biological count assays as a natural use case, evaluating CountsDiff on single-cell RNA-seq imputation in a fetal cell and heart cell atlas. Remarkably, we find that even this simple instantiation matches or surpasses the performance of a state-of-the-art discrete generative model and leading RNA-seq imputation methods, while leaving substantial headroom for further gains through optimized design choices in future work.

TL;DR: Diffusion Model for natural numbers, application on images and scRNA-seq imputation.