Ageing BIOmarker Study in Singaporeans
NCT Number: NCT06555978
Acronym: ABIOS
Status: ACTIVE_NOT_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Healthy Aging|Biological Aging|Lifestyle Factors
Sponsor: National University of Singapore
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 420
Study Design: Observational Model: |Time Perspective: p
Start Date: 2021-03-12
Completion Date: 2024-08
Locations: Centre for Healthy Longevity at Alexandra Hospital, Singapore, 159964, Singapore

Summary:
The Ageing BIOmarker Study in Singaporeans (ABIOS) aims to understand the biological aging processes and how they affect health among people in Singapore. As people grow older, their risk of developing chronic diseases increases. This study aims to better understand the biological changes that come with age, particularly in three major ethnic groups: Chinese, Malay, and Indian adults over 21 years old. By examining a range of health indicators such as DNA methylation, inflammation, metabolism, cardiovascular health, physical function, and physical activity (i.e., molecular, physiological, and digital biomarkers of ageing), the study seeks to identify how ethnicity, lifestyle, and socioeconomic factors influence ageing. This unique study focuses on an all-Asian population, aiming to enhance our understanding of healthy aging across different ethnic groups.

Primary Outcome Measures: blood DNA methylation, DNA methylation ageing clock, years, Baseline
Secondary Outcome Measures: Carotid-femoral Pulse Wave Velocity, Arterial stiffness measured by pulse wave velocity, m/s, Baseline|Handgrip strength, Handgrip strength measured by dynamometer, kg, Baseline|8-repetition maximal strength, Lower body strength measured by maximum weight for 8 leg extension repetitions, kg, Baseline|Skin autofluorescence, Skin autofluorescence measured by advanced glycation end products, Baseline|Objective physical activity, Objective physical activity measured by an activity tracking monitor, Baseline|Facial age, Facial ageing clock based on 3D face morphometry, years, Baseline|Complete red blood cell (RBC) count, Clinical blood parameters, RBC x 10\^12/L, Baseline|Total white blood cell (WBC) count, Clinical blood parameters, WBC x 10\^9/L, Baseline|Total cholesterol, Lipid profile panel, mmol/L, Baseline|HDL cholesterol, Lipid profile panel, mmol/L, Baseline|LDL cholesterol, Lipid profile panel, mmol/L, Baseline|Triglycerides, Lipid profile panel, mmol/L, Baseline|Fasting blood glucose, Clinical blood parameters, mmol/L, Baseline|Total protein, Liver profile panel, mmol/L, Baseline|Total bilirubin, Liver profile panel, umol/L, Baseline|Alkaline phosphatase (ALP), Clinical blood parameters, U/L, Baseline|Insulin, Clinical blood parameters, Roche immunoassay, mU/L, Baseline|HbA1c, Clinical blood parameters, %, Baseline
Other Outcome Measures: Blood pressure, Central and brachial blood pressure measurements, mmHg, Baseline|Waist-to-hip ratio, Waist-to-hip circumference ratio, Baseline|Bone mineral density, Bone mineral density measured by DEXA scan, g/cm\^2, Baseline|Fat-free mass, Fat-free mass measured by DEXA scan, kg, Baseline|Fat mass, Fat mass measured by DEXA scan, kg, Baseline|Arm curl repetitions, Number of arm curl repetitions at a certain weight in 30 seconds, Baseline|Backscratch test, Backscratch test to assess upper body flexibility, distance between fingers in cm, Baseline|Sit-to-stand repeitions, Number of chair sit-to-stand repetitions in 30 seconds, Baseline|4-metre walk, Time it takes for the participant to walk 4 metres, seconds, Baseline|Habitual physical activity, Habitual physical activity patterns reflected by the Global Physical Activity Questionnaire, Baseline|Cognitive function, Cognitive function test assessed by the Montreal Cognitive Assessment (MoCA), Baseline|Frailty, Frailty assessed by the FRAIL scale (fatigue, resistance, aerobic capacity, illnesses, and loss of weight), with three categories: robust (score=0), prefrail (score=1-2), and frail (score=3-5), Baseline|Risk of malnutrition, Risk of malnutrition assessed by the Mini Nutritional Assessment (MNA), with three categories: malnourished (0-7 points), at risk of malnutrition (8-11 points), normal nutritional status (12-14 points), Baseline|Saliva DNA methylation status, DNA methylation ageing clock, years, Baseline