Two-level ESPB in Total Knee Arthroplasty
NCT Number: NCT06470542
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: PHASE4
Conditions: Knee Osteoarthritis|Knee Pain Chronic|Knee Arthritis
Interventions: DRUG: 20 ml of Ropivacaine 0.2% Injectable Solution|DRUG: 2 x 20ml of Ropivacaine 0.2% Injectable Solution
Sponsor: Poznan University of Medical Sciences
Sex: ALL
Age: OLDER_ADULT
Enrollment: 60
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-09-30
Completion Date: 2025-10-30
Locations: Poznan University of Medical Sciences, Poznan, Poznań, 61-701, Poland

Summary:
Effect of two-level ESPB in Total Knee Arthroplasty

Primary Outcome Measures: Total Opioid Consumption, Total opioid consumption after surgery - within 48 hours after surgery, 48 hours after surgery
Secondary Outcome Measures: Time to first rescue opioid analgesia, Time after surgery when the patient needs opiate for the first time, 48 hours after surgery|Numerical Rating Scale [range 0:10], Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt), 8 hours after surgery|Numerical Rating Scale [range 0:10], Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt), 12 hours after surgery|Numerical Rating Scale [range 0:10], Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt), 24 hours after surgery|Numerical Rating Scale [range 0:10], Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt), 48 hours after surgery|NLR, neutrophil-to-lymphocyte ratio, 24 hours after surgery|NLR, neutrophil-to-lymphocyte ratio, 48 hours after surgery|PLR, platelet-to-lymphocyte ratio, 24 hours after surgery|PLR, platelet-to-lymphocyte ratio, 48 hours after surgery|Quadriceps muscle strength assessed using medical research council scale [range 0:5], Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating, 4 hours after surgery|Quadriceps muscle strength assessed using medical research council scale [range 0:5], Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating, 8 hours after surgery|Quadriceps muscle strength assessed using medical research council scale [range 0:5], Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating, 12 hours after surgery|Quadriceps muscle strength assessed using medical research council scale [range 0:5], Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating, 24 hours after surgery|Quadriceps muscle strength assessed using medical research council scale [range 0:5], Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating, 48 hours after surgery