Children With High Genetic Susceptibility Benefit More From Short-term Physical Activity Interventions
NCT Number: NCT06583421
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Physical Inactivity|Obesity, Childhood
Interventions: BEHAVIORAL: 4-week MVPA intervention
Sponsor: China Medical University, China
Sex: ALL
Age: CHILD
Enrollment: 140
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Start Date: 2022-04-01
Completion Date: 2022-08-01
Locations: China Medical University, Shenyang, China

Summary:
Sharp increase in childhood obesity has been regarded as one of the most serious but preventable global public health challenges. Engaging children in moderate-to-vigorous physical activity (MVPA) is important to address the obesity problem as it is associated with a host of obesity outcomes including body weight, BMI, body fat percentage, waist circumference, lean body mass, systolic blood pressure, insulin sensitivity, cardiovascular health, and cognitive development. In China, only about one-third of children meet the recommended guidelines of at least 60 minutes of MVPA per day, and obesity rates are rising.

Children with different generic characteristics may benefit differently from MVPA, which should not be neglected when conducting interventions among children. However, most of the evidence about how genes interact with MVPA on obesity among children were addressed from cross-sectional design or synthetic lifestyle interventions. Change-on-change analysis was used in our study based on a randomized controlled trial of MVPA intervention to discusses the effect of genetics and physical activity on obesity indicators. In addition, investigators used Generic risk scores (GRSs) based on 14 BMI-associated SNPs to assess generic variation of Chinese children.

Primary Outcome Measures: Physical activity strength, Strength was measured by Tri-axial body motion recorder (ActiGraph, Wgt3x-BT, USA) to maintain relative intensity. Children were required to wear ActiGraph by a professional investigator on the left wrist, loosely tightened, and required to wear it at all times except for the shower during the intervention for 7 days., During the 4-week intervention|Height, eight was measured to the nearest 0.1cm using Height Measuring Ruler (Selcom, Germany)., At baseline and after 4-week of intervention|Body weight, Body weight was measured to the nearest 0.1kg using Body Composition Analyzer (DC-13, Parade, Japan), At baseline and after 4-week of intervention|Fat mass, Fat mass was measured to the nearest 0.1kg using Body Composition Analyzer (DC-13, Parade, Japan)., At baseline and after 4-week of intervention|Waist circumference, Waist circumference was measured to the nearest 0.1cm with measuring tape., At baseline and after 4-week of intervention|Hip circumference, Hip circumference was measured to the nearest 0.1cm with measuring tape., At baseline and after 4-week of intervention|Preperitoneal fat, Preperitoneal fat was measured by ultrasonography. The thickness and area of preperitoneal fat was measured with a linear array probe L12-5 (38 mm, 5-12 HZ) according to the method of Suzuki., At baseline and after 4-week of intervention|Abdominal subcutaneous fat thickness, Abdominal subcutaneous fat thickness was measured by ultrasonography. The thickness and area of abdominal subcutaneous fat was measured with a linear array probe L12-5 (38 mm, 5-12 HZ) according to the method of Suzuki., At baseline and after 4-week of intervention