Application of Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament Under Laparoscopic Direct Vision in Laparoscopic Renal Surgery
NCT Number: NCT06550869
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Postoperative Pain|Analgesia|Quadratus Lumborum Block|Laparoscopic Renal Surgery
Interventions: PROCEDURE: Anterior Quadratus Lumborum Block at the lateral supra-arcuate ligament under laparoscopic direct vision|PROCEDURE: Local infiltration anesthesia
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 66
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-08-14
Completion Date: 2025-08
Locations: Second affiliated Hospital School of Medicine,Zhejiang University, Hangzhou, Zhejiang, China

Summary:
Evaluation of the effectiveness of Anterior Quadratus Lumborum Block at the lateral supra-arcuate ligament under laparoscopic direct vision compared to local infiltration anesthesia for postoperative analgesia after laparoscopic renal surgery in patients.A randomized controlled trial involving 66 patients undergoing laparoscopic renal surgery will assign them randomly to an experimental group or a control group.The patients in experimental group will receive Anterior Quadratus Lumborum Block at the lateral supra-arcuate ligament under laparoscopic direct vision.The patients in control group will receive local infiltration anesthesia.The primary outcome measure is the cumulative consumption of intravenous morphine equivalents at postoperative 24 hours.The secondary outcomes include the cumulative consumption of intravenous morphine equivalents at postoperative 2, 4, 6, 12 and 48 hours, Numeric Rating Scale(NRS) score at rest and during activity (coughing) at postoperative 2, 6, 24 and 48 hours, Global Comfort Questionnaire(GCQ) Comfort Status Scale Score, Quality of Recovery-15(QoR-15) Postoperative Recovery Scale Score, time of the first press on the Patient-Controlled Analgesia pump, nausea, vomiting, skin itching, drowsiness, or other adverse reactions, regional anesthesia-related complications such as local anesthetic toxicity and length of postoperative hospital stay after surgery.

Primary Outcome Measures: intravenous morphine equivalents, The cumulative consumption of intravenous morphine equivalents, Postoperative 24 hours
Secondary Outcome Measures: intravenous morphine equivalents, The cumulative consumption of intravenous morphine equivalents, Postoperative 2, 4, 6, 12 and 48 hours|Numeric Rating Scale, Numeric Rating Scale（NRS） score at rest and during activity (coughing),the pain score is from 0-10,0 is no pain,10 is the most., postoperative 2, 6, 24 and 48 hours|Global Comfort Questionnaire, Global Comfort Questionnaire（GCQ） Kolcaba Scale Score,it includes 28 questions,1 is not agree with,4 is very agree with,the total score is 114., Preoperative and postoperative 24 hours|Quality of Recovery-15, Quality of Recovery-15（QoR-15） Postoperative Recovery Scale Score,it includes 15 questions,0 is the worst,10 is the best,total score is 150., Postoperative 24 hours|Time of the first press on Patient-Controlled Analgesia, Time of the first press on the Patient-Controlled Intravenous Analgesia pump, Postoperative 48 hours|adverse reactions, Nausea, vomiting, skin itching, drowsiness, and other adverse reactions, Postoperative 72 hours|Regional anesthesia-related complications, Regional anesthesia-related complications such as local anesthetic toxicity, Postoperative 72 hours|Length of hospital stay, Length of postoperative hospital stay, Postoperative 10 days