Honey as A Wound Care Modality in Treating Deep Neck Space Abscess
NCT Number: NCT06562257
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: PHASE2
Conditions: Neck Abscess
Interventions: OTHER: Honey|OTHER: PHMB Solution
Sponsor: Gadjah Mada University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 36
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-06-19
Completion Date: 2025-06-30
Locations: Dr. Sardjito General Hospital, Yogyakarta, D.I Yogyakarta, 55281, Indonesia

Summary:
This study investigates the effectiveness of honey as a treatment for deep neck space abscesses, comparing it to standard wound care methods. Conducted as a randomized clinical trial, it aims to determine whether honey can offer a viable alternative or improvement in managing this condition. The research assesses outcomes related to healing, infection control, and overall patient recovery.

Primary Outcome Measures: Wound Assessment, The wound was assessed by the research assistant using the Bates-Jensen Wound Assessment Tool, BWATs was measured on the first, seventh, and fourteenth days from abscess incision.|Wound Measurements, Wound measurements included length, width, and depth in cm, with the largest width and length used for data to report wound area in cm\^2. The wound depth was measured using a probe perpendicular to the wound's length and width., The wound was measured on the first, seventh, and fourteenth days from abscess incision.|Bacterial Colony, Bacterial culture results and the number of bacterial colonies served as indicators of infection improvement. Swabs from the wound bed were sent to the Microbiology laboratory., Pus aspiration was performed by the resident doctor who conducted the dressing on the first and fourteenth days from abscess incision|Cytokine and Growth Factor Expression, Immunopathological evaluation of wound healing involved tissue samples sent to the Anatomical Pathology laboratory for analysis of IL-1, TNF-α, and VEGF expression. Tissue sampling was performed using nasopharyngeal biopsy forceps, and the preserved tissue was sent for analysis., Tissue sampling was performed by the resident doctor who conducted the dressing on the first and fourteenth days from abscess incision
Secondary Outcome Measures: Vital Sign Examinations, Vital signs consist of blood pressure (mmHg), heart rate per minute, respiration rate per minute, temperature (°C), and saturation (%) which are useful for monitoring patients in this study., Vital Signs were performed everyday throughout patient's admission in the wards.|Blood Gas Analysis, Blood gas analysis showed by measuring pH, pCO2 (mmHg), HCO3 (mmol/L), pO2 (mmHg), and BE (mmol/L) status., Blood gas analysis were performed throughout patient's admission in the wards.|Complete Blood Count (CBC), Complete blood count performed included, Hemoglobin (g/dL), RBC (10\^6/uL), WBC (10\^3/uL), Platelet (10\^3/uL), and blood type., CBC were performed throughout patient's admission in the wards.|Liver Function Tests, Liver function tests typically include SGOT (U/L), SGPT (U/L), bilirubin serum (mg/dL), INR (international normalized ratio), prothrombin time (PT) and activated partial thromboplastine time (APTT) in second., Liver function tests were performed throughout patient's admission in the wards.|Kidney Function Tests, Kidney function test such as albumin (g/dL), BUN (mg/dl), creatinine serum (mg/dL), uric acid (mg/dL) and electrolytes (mmol/L): sodium, potassium, chloride ., Kidney function tests were performed throughout patient's admission in the wards.|Blood Glucose Test, A blood glucose test measure the amount of glucose in patient blood to hel diagnose or monitor diabetes either as a comorbidity or not ny doing a finger-picker test or a blood draw from patient vein, Blood glucose test was performed throughout patient's admission in the wards.