Haemophilus Influenzae Pneumonia in Adults
NCT Number: NCT06517277
Acronym: REHALIgraviTY
Status: NOT_YET_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Haemophilus Influenzae Pneumonia
Interventions: OTHER: Collection of data from the patient's medical file
Sponsor: Assistance Publique - Hôpitaux de Paris
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 300
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-08
Completion Date: 2025-02
Locations: Hôpital Béclère, Clamart, 92140, France|Hôpital Beaujon, Clichy, 92110, France|Hôpital Raymond Poincaré, Garches, 92380, France|Hôpital du Kremlin-Bicêtre, Le Kremlin-Bicêtre, 94270, France|Hôpital Lariboisière, Paris, 75010, France|Hôpital Saint-Louis, Paris, 75010, France|Hôpital Saint-Louis, Paris, 75010, France|Hôpital Saint-Antoine, Paris, 75012, France|Hôpital La Pitié Salpêtrière, Paris, 75013, France|Hôpital Cochin, Paris, 75014, France|Hôpital Européen Georges Pompidou, Paris, 75015, France|Hôpital Necker-Enfants Malades, Paris, 75015, France|Hôpital Bichat, Paris, 75018, France

Summary:
Haemophilus influenzae is a Gram-negative coccobacillus capable of colonizing and infecting the human respiratory tract.

In the adult population, patients with an abnormality of their mucociliary epithelium and a deficiency in innate or adaptive immunity are particularly exposed.

The Infectious and Tropical Diseases department of Necker-Enfants Malades hospital has noted a recent increase in the number of cases of respiratory infections due to H. influenzae, with a high frequency of early relapses and recurrences despite appropriate treatment.

The research focuses on lower respiratory infections (pneumonia) caused by Haemophilus influenzae in adults, excluding pneumonia acquired under mechanical ventilation linked to Haemophilus influenzae in patients in 13 AP-HP hospitals during 12 months, from 09/01/2022 to 08/31/2023.

Primary Outcome Measures: Relapse associated factors of Haemophilus influenzae pneumonia, Relapse associated factors with the Haemophilus influenzae pneumonia in hospitalized adult.

Relapse of Haemophilus influenzae pneumonia defined as:

* Definite relapse: acute respiratory symptoms (cough and/or dyspnea and/or purulent sputum), inflammatory syndrome (clinical: fever ≥ 38.5°C or biological: CRP ≥ 30 mg/L), respiratory antibiotic therapy started by the clinician, new good quality respiratory sample positive in culture for Haemophilus influenzae within 90 days following the first episode.
* Probable relapse: acute respiratory symptoms, inflammatory syndrome (clinical: fever ≥ 38.5°C or biological: CRP ≥ 30 mg/L), respiratory antibiotic therapy started by the clinician, absence of microbiological documentation of the new episode, within 30 days following the first episode., 15 months
Secondary Outcome Measures: Severity associated factors in Haemophilus influenzae pneumonia, Identify the factors associated with severity in Haemophilus influenzae pneumonia. Severity is defined as: oxygen therapy \> 3 L/minute or need for hospitalization in intensive care unit or death., 15 months|Antibiotic resistance profiles of Haemophilus influenza strains, Specify the antibiotic resistance profiles of the strains of Haemophilus influenzae responsible for pneumonia during the study period., 15 months|Pulmonary radiological patterns in Haemophilus influenzae pneumonia, Describe the pulmonary radiological patterns associated with Haemophilus influenzae pneumonia., 15 months