Cognitive Enhancement in Unipolar Depression With Yoga
NCT Number: NCT06472492
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Unipolar Depression
Interventions: BEHAVIORAL: Adjuvant yoga intervention
Sponsor: University of Pittsburgh
Collaborators: Fogarty International Center of the National Institute of Health|National Institute of Mental Health and Neuro Sciences, India
Sex: ALL
Age: ADULT
Enrollment: 76
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2024-05-17
Completion Date: 2025-12-31
Locations: National Institute of Mental Health and Neuroscience (NIMHANS), Bengaluru, Karnataka, 560029, India

Summary:
It is evident from recent studies that cognitive deficits persist even after remission of depressive episode. Hence, in this study, the investigators would like to see whether specific Yoga practice will help in enhancing cognitive abilities in this population.

Primary Outcome Measures: Working memory (Digit Span), To study the change in working memory in intervention group as measured by digit span test in comparison to treatment as usual. The range of the scale is 0 to 28 points and higher is better memory., Baseline, after six weeks yoga and after four weeks of completion of yoga|Attention and processing speed(Trail A and B), To study the change in attention and processing speed in intervention group as measured by Trail A and B test in comparison to treatment as usual. The scoring is based on time taken to complete the test. Less the time taken, better the attention and processing speed., Baseline, after six weeks yoga and after four weeks of completion of yoga|Cognitive flexibility, To study the change in cognitive flexibility in intervention group as measured by stroop test test in comparison to treatment as usual. Stroop test also measures time to complete the task and less the time, better the score is., Baseline,after six weeks yoga and after four weeks of completion of yoga|Cognitive inhibition, To study the change in cognitive inhibition in intervention group as measured by stroop test test in comparison to treatment as usual., Baseline,after six weeks yoga and after four weeks of completion of yoga
Secondary Outcome Measures: Sustainability of working memory, To compare the difference in the working memory 4 weeks post adjuvant yoga intervention, as measured by the scores on Digit span test.test in comparison to treatment as usual.The range of the scale is 0 to 28 points and higher is better memory., four weeks of completion of yoga|Sustainability of attention and processing speed, To compare the difference in attention and processing speed 4 weeks post adjuvant yoga intervention, as measured by Trail Making A and B tests. The scoring is based on time taken to complete the task. Less the time taken, more is the attention and processing speed., four weeks of completion of yoga|Sustainability of cognitive flexibility, To compare the difference incognitive flexibility 4 weeks post adjuvant yoga intervention, as measured by Stroop test. Stroop test also measures time to complete the task and less the time, better the cognitive flexibility is., four weeks of completion of yoga|Sustainability of cognitive inhibition, To compare the difference in cognitive inhibition weeks post adjuvant yoga intervention, as measured by the scores on Stroop test., four weeks of completion of yoga