pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Effects of Portrayals of Successful Treatment and Role Fulfillment on Mental Illness Stigma
NCT Number: NCT06509386
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Mental Illness
Interventions: OTHER: Major Depressive Disorder without treatment or role fulfillment|OTHER: Major Depressive Disorder with treatment but no role fulfillment|OTHER: Major Depressive Disorder without treatment but with role fulfillment|OTHER: Major Depressive Disorder with treatment and role fulfillment|OTHER: Schizophrenia without treatment or role fulfillment|OTHER: Schizophrenia with treatment but no role fulfillment|OTHER: Schizophrenia without treatment but with role fulfillment|OTHER: Schizophrenia with treatment and role fulfillment
Sponsor: Yale University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 400
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Start Date: 2024-06-15
Completion Date: 2024-08-15
Locations: Empowerment to Heal - Uganda, Iganga, Uganda

Summary:
This study aims to measure levels of mental illness stigma based on successful treatment and societal role fulfillment of the individual portrayed with mental illness.

Primary Outcome Measures: Personal Acceptance Scale (PAS), The PAS is a questionnaire targeted to public stigma, the "negative attitudes, beliefs, and behaviors held within a community" against individuals with mental illness. Each yes adds one point to the scale, and five questions from each scale were reverse-scored to match the direction of the scale. There were ten questions, therefore it generated a score between zero and ten. Higher scores indicated more acceptance and less stigma towards mental illness, while lower scores indicated less acceptance and more stigma towards mental illness., One year. For each interview, approximately 60 minutes.|Broad Acceptance Scale (BAS), The BAS is a questionnaire targeted to distal public stigma. Each yes adds one point to the scale, and five questions from each scale were reverse-scored to match the direction of the scale. There were ten questions, therefore it generated a score between zero and ten. Higher scores indicated more acceptance and less stigma towards mental illness, while lower scores indicated less acceptance and more stigma towards mental illness., One year. For each interview, approximately 60 minutes.|Attributed Stigma Scale, Attributed stigma scale will be a modification of the PAS to gather understanding of what participants believe the attitudes of others in their community are. Each yes adds one point to the scale, and five questions from each scale were reverse-scored to match the direction of the scale. There were ten questions, therefore it generated a score between zero and ten. Higher scores indicated more acceptance and less stigma towards mental illness, while lower scores indicated less acceptance and more stigma towards mental illness., One year. For each interview, approximately 60 minutes.
Trial of JYB1904 in Chronic Spontaneous Urticaria.
NCT Number: NCT06509334
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: PHASE2
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: JYB1904|DRUG: JYB1904|DRUG: Omalizumab
Sponsor: Jemincare
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 135
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-07-15
Completion Date: 2026-07-15
Locations: Peking University People's Hospital, Beijing, Beijing, 100044, China

Summary:
This Phase II Trial is Meant to Evaluate the Efficacy, Safety and Tolerability of JYB1904 Injection in Patients With Chronic Spontaneous Urticaria.

Primary Outcome Measures: Urticaria activity score used for 7 consecutive days(UAS7), Change from baseline in urticaria activity score used for 7 consecutive days (UAS7) at weeks 8, 12, and 16.Score 0-42, UAS7=0 for complete remission, Baseline through 16 weeks
Secondary Outcome Measures: Urticaria activity score used for 7 consecutive days(UAS7), Change from baseline in UAS7 at weeks 4, 24 and 32.Score 0-42, UAS7=0 for complete remission, Baseline through 32 weeks|Itch severity score used for 7 consecutive days(ISS7), Change from baseline in itch severity score used for 7 consecutive days(ISS7) at weeks 4, 8, 12, 16, 24 and 32.Score 0-21, ISS7=0 for complete remission of itch, Baseline through 32 weeks|Hive severity score used for 7 consecutive days (HSS7), Change from baseline in hive severity score used for 7 consecutive days(HSS7) at weeks 4, 8, 12, 16, 24, 32.Score 0-21, HSS7=0 for complete remission of hives, Baseline through 32 weeks|Angioedema activity score used for 7 consecutive days(AAS7), Change from baseline in angioedema activity score used for 7 consecutive days(AAS7) at weeks 4, 8, 12, 16, 24, 32.Score 0-105, higher scores mean a worse outcome, Baseline through 32 weeks|Urticaria activity score used for 7 consecutive days(UAS7), Proportion of subjects with UAS7=0 at weeks 4, 8, 12, 16, 24, 32.Score 0-42, UAS7=0 for complete remission, Baseline through 32 weeks|Dermatology Life Quality Index(DLQI), Change from baseline in Dermatological Life Quality Index (DLQI) at weeks 4, 8, 12, 16, 24 and 32.Score 0-30, higher scores mean a worse outcome, Baseline through 32 weeks|Safety and tolerability, Adverse events (AEs) and serious adverse events (SAEs), Baseline through 32 weeks|Trends in serum total immunoglobulin E(IgE), Serum total IgE levels at weeks 4, 8, 12, 16, 24 and 32, Baseline through 32 weeks|Positive detection rate of anti-drug antibody (ADA), ADA positive detection rate at 32 weeks, Baseline through 32 weeks
Comparison Between Loupe-Assisted Varicocelectomy With Nitroglycerin Instillation and Microscopic Varicocelectomy
NCT Number: NCT06509321
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Varicocele
Interventions: PROCEDURE: subinguinal loupe-assisted varicocelectomy (LV)|PROCEDURE: subinguinal microscopic varicocelectomy (MV)
Sponsor: Fayoum University Hospital
Sex: MALE
Age: ADULT
Enrollment: 60
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2023-05-01
Completion Date: 2024-05-01
Locations: Fayoum University Hospital, Fayoum, 63611, Egypt

Summary:
This study aims to compare the efficacy and safety of sub inguinal loupe-assisted varicocelectomy with nitroglycerin instillation as a vasodilator and compare it versus sub inguinal microscopic varicocelectomy

Primary Outcome Measures: To assess the efficacy and safety of Loupe varicocelectomy using nitroglycerine to induce vasodilatation during operation., by assessing number of ligated veins, visualization of artery (during operation), and to assess PSV \& EDV for testicular artery, \& semen parameter (After 3 months Post operation ), 3 months follow up
Secondary Outcome Measures: to assess the efficacy and safety of nitroglycerine instillation during Loupe varicocelectomy comparing to the standard Microscopic varicocelectomy., by assessing number of ligated veins, visualization of artery (during Loupe varicocelectomy using nitroglycerine instillation during operation), and to assess PSV \& EDV for testicular artery \& semen parameter (After 3 months Post operation) comparing to the standard Microscopic varicocelectomy., 3 months follow up
Effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain and Bacterial Reduction in Mandibular Premolars With Necrotic Pulps. .
NCT Number: NCT06509295
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Intervention
Interventions: OTHER: Calcium Hypochlorite as Root Canal Irrigant
Sponsor: Cairo University
Sex: ALL
Age: ADULT
Enrollment: 30
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-08-29
Completion Date: 2025-05-29

Summary:
This study aims to assess the effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain and Bacterial Reduction in Mandibular Premolars with Necrotic Pulps.

Primary Outcome Measures: Effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain in Mandibular Premolars with Necrotic Pulps., measuring tool: Numerical Rating Scale (NRS). Unite of measurement: Categorical None 0 Mild 1-3 Moderate 4-6 Severe 7-10 Time of measurements: At 6, 12, 24, 48- hours post-treatment., measured at 6, 12, 24, 48 hours after single visit treatment
Secondary Outcome Measures: Effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Bacterial Reduction in Mandibular Premolars with Necrotic Pulps., Intracanal bacterial load reduction will be determined by bacterial counting using agar culture technique after root canal preparation (CFUs/ml), The growth will be semi quantitatively determined as very heavy, heavy, moderate, sparse and very sparse depending on the CFU ranging from \>100,000,˂100,000,˂10,000,˂1,000, ˂100 colony forming unit per 1 ml BHI respectively., T0=Baseline immediate after access preparation . T1=Post-instrumentation. T1(within an hour)|Number of analgesic tablets taken by the patient after endodontic treatment, Number of analgesic tablets taken by the patient after endodontic treatment Up to 48 hours postoperative.

Measuring tool: counting Measurment unite: numerical., Up to 48 hours postoperative.
Intraoral Scanning v.s Desktop Scanning
NCT Number: NCT06509269
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Edentulous Jaw
Interventions: PROCEDURE: intraoral scanning|PROCEDURE: Desktop scanning
Sponsor: British University In Egypt
Sex: ALL
Age: CHILD, ADULT, OLDER_ADULT
Enrollment: 20
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Start Date: 2020-10-01
Completion Date: 2023-10-01
Locations: British University in Egypt, Cairo, Shorook, Egypt

Summary:
The aim of this study was to evaluate the effect of intraoral scanning versus desktop scanning on the retention and adaptation of maxillary denture bases in completely edentulous patients.

Primary Outcome Measures: Retention of denture base, Measuring tool: Digital force meter, Measuring unit: Newton (N), "through study completion, an average of 1 year"|Adaptation of denture base, Measuring tool: Geomagic Control X software, Measuring Unit: Millimeter (mm), "through study completion, an average of 1 year"
Different Methods of Tranexamic Acid Application in Controlling Peri Operative Bleeding in Gynecomastia Surgery
NCT Number: NCT06509256
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: EARLY_PHASE1
Conditions: Pharmacological-Aggravated Urticaria
Interventions: DRUG: Tranexamic acid injection
Sponsor: Assiut University
Sex: MALE
Age: CHILD, ADULT
Enrollment: 50
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Start Date: 2024-07-20
Completion Date: 2025-04-20

Summary:
Different Methods of Tranexamic Acid Application in Controlling Peri-Operative Bleeding in Gynecomastia Surgery

Primary Outcome Measures: Intraoperative blood loss during liposuction in milliliters, The volume of blood collected in the liposuction bottle during the surgical procedure will be measured. This will be reported as mean volume in milliliters with standard deviation for each study group., "Intraoperatively" Unit of Measure: Milliliters (mL)
Secondary Outcome Measures: Duration of surgical drain placement in days, The number of days the surgical drain remains in place post-operatively, until drainage is less than 30 mL per 24 hours. This will be reported as mean number of days with standard deviation for each study group., From immediate post-operation until drain removal (expected within 3 to 7 days)" Unit of Measure: Days|Change in hemoglobin concentration from baseline to 24 hours post-operation, The difference in hemoglobin concentration between preoperative baseline and 24 hours post-operation. This will be reported as mean change in g/dL with standard deviation for each study group., Baseline (within 24 hours before surgery) and 24 hours post-operation" Unit of Measure: Grams per deciliter (g/dL)|Extent of post-operative ecchymosis at 7 days, The extent of ecchymosis will be assessed using a standardized photographic scale, ranging from 0 (no ecchymosis) to 4 (severe ecchymosis). This will be reported as median score with interquartile range for each study group.", "7 days post-operation" Unit of Measure: Ordinal scale score (0-4)|Changes in coagulation profile at 24 hours post-operation, Changes in prothrombin time (PT), activated partial thromboplastin time (aPTT), and international normalized ratio (INR) from baseline to 24 hours post-operation. These will be reported as mean changes with standard deviations for each parameter in each study group., "Baseline (within 24 hours before surgery) and 24 hours post-operation" Unit of Measure: Seconds for PT and aPTT, no units for INR
Prediction of Significant Liver Fibrosis
NCT Number: NCT06509230
Acronym: PSLF
Status: RECRUITING
Study Type: OBSERVATIONAL
Conditions: Liver Fibrosis
Interventions: OTHER
Sponsor: Huang Haijun
Collaborators: East China University of Science and Technology
Sex: ALL
Age: ADULT
Enrollment: 700
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-07-20
Completion Date: 2026-12-31
Locations: Haijun Huang, Hangzhou, Zhejiang, 310014, China

Summary:
The deep learning method based on convolutional neural network (CNN) was used to extract the relevant features of liver fibrosis classification from the multi-modal information of digital pathological sections, clinical parameters and biomarkers of a large number of existing cases of liver puncture, and the U-Net architecture of CNN was used to segment and extract the features of clinical medical images.

Primary Outcome Measures: Model development, Imaging (such as CT scan, MRI, X-ray, etc.) features and clinical parameters of patients were extracted, including population baseline characteristics (such as age, gender, comorbiditions, etc.), blood biochemical indicators (such as blood glucose, lipids, liver function indicators, etc.), and blood cytology indicators (such as white blood cell count, red blood cell count, etc.). Completed case selection and cohort establishment, multi-modal feature extraction and model development, 2024.6-2024.12
Secondary Outcome Measures: Build a multi-modal big data liver fibrosis early warning cloud platform system, We intend to design a cloud platform with data storage, processing and analysis components.Select the appropriate technology stack to ensure that the platform has the ability to handle large-scale data, and has good scalability and performance.The previously built multimodal liver fibrosis precision typing model was then embedded into the platform, ensuring that the model could handle a variety of data types and integrate seamlessly with other components of the platform.At the same time, the stream processing technology is used to integrate the real-time monitoring and analysis function of the platform, so as to make rapid prediction and classification of the newly acquired liver fibrosis case data.The accuracy and stability of the model were further verified in the multi-center clinical data, and the multi-modal big data liver fibrosis early warning cloud platform system was built, 2025.1-2025.12
Other Outcome Measures: Evaluation Multi-modal big data liver fibrosis warning platform system effectiveness, To test the effectiveness of the multi-modal big data liver fibrosis warning platform system in a real multi-center clinical environment. We will also explore the possibility of using the platform for long-term follow-up of patients, remote testing of patients and regular assessment of disease progression, 2026.1-2026.12
Real-world Evaluation of JBA GlucoTrojan With Reducose® on Glycemic Response
NCT Number: NCT06509204
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Food Habits
Interventions: DIETARY_SUPPLEMENT: Glucotrojan
Sponsor: Tastermonial Inc
Collaborators: WCG clinical|Affordable Quality Pharmaceuticals
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 30
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Start Date: 2023-04-04
Completion Date: 2023-06-04
Locations: Tastermonial, Cupertino, California, 95014, United States

Summary:
The project is focused on evaluating the real-world efficacy of JBA GlucoTrojan, a powdered supplement sachet containing Reducose, a natural water extract of White Mulberry Leaf, which has been scientifically proven to reduce the absorption of sugars and carbs by up to 40%. The study aims to compare the effect of consuming GlucoTrojan with a meal (Test Meal) vs. having the meal alone (control) on the blood sugar response of 50 healthy adults, pre-diabetes, or non-insulin dependent diabetes, over a period of 14 days. It is expected that GlucoTrojan will reduce the incremental area under the curve and the peak for plasma glucose concentration over 120 minutes in normoglycemic adults when compared to the response to a control meal.

Primary Outcome Measures: iAUC Calculation, Each participant's eating period (called a "meal") is normalized and overlaid in a data frame that captures glucose values over the course of the test. Several other metrics are computed, such as maximum and minimum values, standard deviation, and others. In particular, the iAUC ("incremental area under the curve"), a measure of the total amount of postprandial blood glucose level increased over the entire 2-hour period after eating. The methodology of iAUC calculation follows the gold standard used in the measurement of the glycemic index (1, 2). The iAUC metric allows our team to easily compare and rank testing results, as well as compare against the pure sugar responses or the sugar tolerance test of an individual., 2-hour period after eating
The Use of Melatonin for Delirium Prevention in Medically Hospitalized Patients
NCT Number: NCT06509191
Acronym: RESTORE
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Delirium
Interventions: DRUG: Intervention 1|DRUG: Intervention 2|OTHER: Control
Sponsor: Sultan Qaboos University
Sex: ALL
Age: OLDER_ADULT
Enrollment: 240
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-09
Completion Date: 2025-06
Locations: Sultan Qaboos University Hospital, Muscat, 123, Oman

Summary:
The high prevalence of delirium in hospitalized older adults, with significant associated morbidity and mortality, emphasize the need for effective prevention strategies. Limited trials have explored melatonin's potential in preventing delirium among patients admitted to general medical wards. Previous trials on melatonin's preventive role in medical wards had limitations, necessitating a robust, double-blinded, placebo-controlled design with a larger sample size. This randomized, double-blind study of melatonin versus placebo aims to investigate the efficacy of melatonin, a neurohormone regulating the sleep-wake cycle, in preventing delirium among medically hospitalized patients aged 65 or older. Given the high prevalence of delirium in this population and its association with adverse outcomes, the study seeks to contribute valuable insights into an effective preventive strategy.

Primary Outcome Measures: Incidence of delirium, Incidence of delirium development during hospitalisation using the 3-Minute Diagnostic Confusion Assessment Method (3D-CAM)., 5 days
Secondary Outcome Measures: Onset time of delirium, 5 days|Duration of delirium during hospitalization, up to 14 days|Sleep pattern and night awakenings, 5 days|Days utilizing physical restraints., 5 days|• Number of rescue medications and the doses utilized for delirium management during hospitalization., 5 days|Length of hospital stay (LOS)., up to 28 days|Requirement to transfer to high dependency unit (HDU) or ICU, up to 28 days|Inpatient all-cause mortality., up to 28 days|28- day all-cause mortality, up to 28 days
Comparison of Different Techniques in the Treatment of Gingival Recession
NCT Number: NCT06509165
Status: COMPLETED
Study Type: OBSERVATIONAL
Conditions: Gingival Recession
Interventions: PROCEDURE: Modified coronally advanced flap technique|PROCEDURE: Tunnel technique
Sponsor: Necmettin Erbakan University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 28
Study Design: Observational Model: |Time Perspective: p
Start Date: 2021-01-01
Completion Date: 2022-12-31
Locations: Necmettin Erbakan University, Konya, 42090, Turkey

Summary:
The aim of this study is to compare the clinical and aesthetic results of different techniques in the treatment of gingival recession.

The main questions it aims to answer are:

* Does the surgical technique preferred by the physician affect the closure rate of gingival recession in the 3rd month?
* Does the surgical technique preferred by the physician affect the closure rate of gingival recession in the 6th month? Participants were informed about the study. Following routine periodontal treatment, surgical operations were performed on the areas with receding gums using different techniques for the patients included in the study.

Primary Outcome Measures: Gingival recession closure amount, How much gingival recession has closed after the operation will be measured., 6 months
A Pilot Study of an Online HIV Stigma Training for Nursing Students in Iran
NCT Number: NCT06509113
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Stigma, Social|HIV Infections
Interventions: BEHAVIORAL: The online HIV-related stigma training|BEHAVIORAL: The online HIV epidemiology training with no specific content on stigma
Sponsor: University of California, San Francisco
Collaborators: Ponce Health Sciences University|Kerman University of Medical Science|Fogarty International Center of the National Institute of Health
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 70
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Start Date: 2024-09-15
Completion Date: 2025-12
Locations: Skill labs at the nursing school of Kerman Medical University, Kerman, 76198-13159, Iran, Islamic Republic of

Summary:
In this study, the investigators will assess the feasibility, acceptability, and preliminary efficacy of online HIV stigma training in reducing stigmatizing attitudes and behaviors of nursing students in simulated clinical visits of patients living with HIV compared to an online HIV epidemiology training with no specific content on stigma.

Primary Outcome Measures: Stigma score, All nursing students will complete a validated stigma scale before and after the training interventions., Up to 4 weeks before and after intervention|Behavioral manifestations of HIV stigma, Before and after the training interventions, all nursing students will meet with a randomly selected simulated patient for an HIV visit. These visits will be video recorded and will be coded and scored for stigmatizing behaviors., Up to 4 weeks before and after intervention|Empathy score, All nursing students will complete a validated empathy scale before and after the training interventions., Up to 4 weeks before and after intervention
Secondary Outcome Measures: The attitudes and behaviors of nursing students after the online HIV stigma training, We will qualitatively examine study participants' real-world behaviors with HIV and at-risk patients to (1) explore if behaviors learned during the intervention carry on in real-world settings, (2) better understand how behaviors are manifested in natural settings, and (3) explore best methods to assess behaviors in real-world scenarios, Three months after the intervention
The Combined Utility of Angio-CT and MRI in Managing Chronic Musculoskeletal Pain: a Prospective Study to Evaluate the Efficacy of Transarterial Microembolization
NCT Number: NCT06509087
Status: RECRUITING
Study Type: OBSERVATIONAL
Conditions: Chronic Musculoskeletal Disease|Transarterial Embolization|Magnetic Resonance Imaging|Angiography|Computed Tomography
Interventions: PROCEDURE: Transarterial microembolization (TAME)
Sponsor: Tri-Service General Hospital
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 60
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-07-25
Completion Date: 2027-07-31
Locations: Tri-Service General Hospital, Taipei, Taiwan

Summary:
Transarterial microembolization (TAME) is a novel treatment option for chronic musculoskeletal pain, especially suitable for patients who have not responded to conservative treatment or are unsuitable for surgical procedures. This minimally invasive technique primarily targets abnormal neovascularization for embolization, relying heavily on precise information provided by various imaging techniques to ensure the effectiveness and safety of the treatment. This study aims to explore the application of integrating preoperative magnetic resonance imaging (MRI) evidence of patient pain and intraoperative high-resolution synchronous imaging information from fused computed tomography (CT) and angiography systems. This integration is intended to enhance preoperative planning, intraoperative guidance, and final treatment outcome assessment, focusing on its crucial contribution to treatment success. It is hoped that this approach will provide pain intervention physicians with reliable diagnostic tools and safe treatment methods, thereby improving treatment outcomes for patients with chronic musculoskeletal pain.

Primary Outcome Measures: Pain relief, Pain relief is measured according to the Visual Analog Scale (VAS) immediately prior to (baseline) and after the TAME procedure (day 0) as well as day 1, week 1, month 1, month 3, and month 6., day 0, day 1, week 1, month 1, month 3, and month 6.
Secondary Outcome Measures: Functional improvement (for shoulder joint), Functional improvement is measured according to Shoulder Pain and Disability Index (SPADI) for patients with chronic shoulder pain immediately prior (baseline) to and after the TAME procedure (day 0) as well as day 1, week 1, month 1, month 3, and month 6., day 0, day 1, week 1, month 1, month 3, and month 6.|Functional improvement (for knee joint), Functional improvement is measured according to the Western Ontario and McMaster Universities Arthritis Index (WOMAC) for patients with chronic knee pain immediately prior (baseline) to and after the TAME procedure (day 0) as well as day 1, week 1, month 1, month 3, and month 6., day 0, day 1, week 1, month 1, month 3, and month 6.
Other Outcome Measures: The technical success rate of TAME procedure, The technical success rate is judged according to the digital subtraction angiography (DSA). A successful procedure is determined by decreased neovascularization via targeted vessels embolization by the fused CT and angiography system., Immediately after the TAME procedure
"I am a Physically Active Person!": A Randomized Controlled Trial Aimed to Increase Levels of Physical Activity Self-Definition and Physical Activity Among a Sample of Inactive Adults
NCT Number: NCT06509061
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Physical Activity Self-Definition|Physical Activity
Interventions: OTHER: Physical Activity Self-Definition|OTHER: Control
Sponsor: University of Manitoba
Collaborators: Research Manitoba
Sex: ALL
Age: ADULT
Enrollment: 120
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Start Date: 2015-09
Completion Date: 2017-04

Summary:
This explanatory sequential mixed methods study investigated if an intervention can increase the physical activity identity and physical activity (PA) of inactive individuals. The intervention condition focused on increasing participant's physical activity self-definition (PASD) through educational sessions and group discussions on the five direct and indirect determinants of PASD (perceived enjoyment, perceived wanting, perceived commitment, perceived trying, perceived ability). The control condition was given general health behaviour education sessions. Researchers conducted interviews with some of the participants after the intervention was completed.

Primary Outcome Measures: Physical Activity Self-Definition, Measured with a 4-item questionnaire using a 7-point Likert scale (1= strongly disagree; 7 = strongly agree), Measured pre-intervention, 5 weeks later at intervention end and 4 weeks post intervention|ActiGraph Accelerometers, Weekly sedentary, light, moderate, and vigorous physical activity minutes were measured using accelerometers, worn at the hip for 7 day during waking hours., Measured pre-intervention, 5 weeks later at intervention end and 4 weeks post intervention
Correlation Between Smartphone Use and Text Neck Posture in Asymptomatic Subjects
NCT Number: NCT06509035
Status: COMPLETED
Study Type: OBSERVATIONAL
Conditions: Smartphone Addiction|Text Neck Posture
Sponsor: Cairo University
Sex: ALL
Age: ADULT
Enrollment: 30
Study Design: Observational Model: |Time Perspective: p
Start Date: 2023-07-01
Completion Date: 2024-06-01
Locations: Misr University for Science and Technology, Giza, Egypt

Summary:
This study will be conducted to investigate the correlation between the number of hours of smartphone usage and severity of text neck posture, cervical ROM, DNF endurance and resting head posture among asymptomatic 18 to 25 years old adults

Primary Outcome Measures: Assessing the average duration of smartphone screen time, A mobile application called Screen Time Restrain Yourself measures smartphone usage in hours over the past week, allowing users to monitor their daily usage without disrupting normal smartphone use., at baseline
Secondary Outcome Measures: Assessment of head and neck posture, Photogrammetry is a reliable method for measuring head and cervical spine postures. It involves taking sagittal photographs of the subject's head tilt angle and neck tilt angle. A camera is positioned at a height corresponding to the seventh cervical vertebra (C7) level, and spherical markers are attached to the right tragus, canthus, and spinal process. The subject is instructed to sit on a chair, maintain a resting head posture, and perform full flexion and extension three times. The average of angles from repeated photos is used to reduce bias. Fatigue time is reported after ten minutes of use with a smartphone., at baseline|Assessment of cervical range of motion, Cervical ROM is measured using a universal goniometer, with subjects placed flat on the floor and supported on a lap. They move their head in flexion and extension, with the goniometer placed over the external auditory meatus, fixed arm perpendicular to the floor, and movable arm with the nose base. For cervical rotation, they turn the head to the left or right side, and for lateral flexion, they touch the ear to a shoulder of the same side. The goniometer is a valid and reliable tool for measuring cervical ROM, with good interrater and intraterrater reliability., at baseline|Assessment of deep neck flexor endurance, The Neck Flexor Muscle Endurance Test (NFMET) involves a subject supine, with hands resting on the abdomen and feet flat on a plinth. The subject performs chin retraction, head and neck lift, and skin folds. The test measures muscle endurance, with males having a longer average hold time than females., at baseline
Longitudinal Study on the Evolution Trend and Influencing Factors of Postoperative Reflux of Esophageal Cancer Based on PEPTEST Technique
NCT Number: NCT06509022
Status: ENROLLING_BY_INVITATION
Study Type: OBSERVATIONAL
Conditions: GASTROINTESTINAL NEOPLASMS
Interventions: DIAGNOSTIC_TEST: PEPTEST test
Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Sex: ALL
Age: CHILD, ADULT, OLDER_ADULT
Enrollment: 138
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-03-01
Completion Date: 2024-12-01
Locations: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China

Summary:
The goal of this observational study intends to explore the evolution trend and related factors of postoperative reflux of esophageal cancer based on PEPTEST detection, in order to identify postoperative reflux

The main question it aims to answer are:

to provide evidence for high-risk groups, improvement of surgical methods for esophageal cancer, and development of health education programs to prevent postoperative reflux.

Using convenient sampling method, patients undergoing esophagectomy in thoracic surgery Department of Cancer Hospital of Chinese Academy of Medical Sciences from January 1, 2023 were continuously enrolled. PEPTEST was performed once before surgery, before discharge, 1 month, 3 months, and 6 months after surgery.

The incidence of pathological reflux at 5 time points before and after surgery was observed and compared (that is, both T-line and C-line were shown). The trend of pepsin content in saliva before and after operation; The relationship between pathological reflux and surgical factors; The relationship between pathological reflux and life habits after operation; Relationship between pathological regurgitation and demographic characteristics.

Primary Outcome Measures: Incidence of pathological regurgitation, Incidence of pathological regurgitation at 5 time points before and after surgery., 2023.1.1-2023.12.1
Nimotuzumab Combined With TGP as First-line Therapy in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma
NCT Number: NCT06509009
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: PHASE2
Conditions: Nasopharyngeal Carcinoma by AJCC V8 Stage
Interventions: DRUG: Nimotuzumab
Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 30
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2024-08-30
Completion Date: 2027-05-30

Summary:
The goal of this study is to learn the efficacy and safety of nimotuzumab combined with toripalimab and gemcitabine/cisplatin regimen treatment recurrent/distant-metastasis nasopharyngeal carcinoma.

Primary Outcome Measures: ORR[RECIST1.1], objective response rate assessed by RECIST 1.1, 3 months
Secondary Outcome Measures: mPFS, median progression-free survival assessed by RECIST 1.1, 1 year|OS, median overall survival, 2 years|2-year PFS rate, 2-year progression-free survival rate assessed by RECIST 1.1, 2 years|DCR, disease control rate assessed by RECIST 1.1, 3 months|DOR, duration of response assessed by RECIST 1.1, 2 years|adverse event, incidence and severity of adverse events, 3 years
Xpert Hepatitis-C Virus (HCV) Test on the GeneXpert Xpress System
NCT Number: NCT06508996
Status: COMPLETED
Study Type: OBSERVATIONAL
Conditions: HCV
Interventions: DIAGNOSTIC_TEST: Xpert HCV
Sponsor: Cepheid
Collaborators: Emory University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 1012
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-02-06
Completion Date: 2024-06-06
Locations: University of Kentucky, Lexington, Kentucky, 40508, United States

Summary:
A multi-site prospective, all comers study that was conducted at geographically diverse locations in the United States.

Primary Outcome Measures: Percent Agreement compared to Patient infected status (PIS), Clinical performance comparing Xpert test to PIS (NAAT + Antibody status), 1 day
Sarcopenia and Bone Mineral Density Relation in Hip Fracture Patients
NCT Number: NCT06508957
Status: COMPLETED
Study Type: OBSERVATIONAL
Conditions: Sarcopenia|Hip Fractures
Sponsor: Kastamonu University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 35
Study Design: Observational Model: |Time Perspective: p
Start Date: 2023-05-01
Completion Date: 2023-11-01
Locations: Gamze Gül Güleç, Kastamonu, 37150, Turkey

Summary:
The study aims to investigate the relationship between sarcopenia and bone mineral density (BMD) in patients with hip fractures using sonographic thigh adjustment ratio (STAR) and dual-energy X-ray absorptiometry (DXA), as well as the relationship of sociodemographic factors, laboratory results, and comorbidities to these measurements.

Cross-sectional research was undertaken on patients with hip fractures in Kastamonu, Turkey. Sarcopenia was identified based on the ISarcoPRM algorithm, which utilizes poor grip strength (\<22 kg for females and \< 32 kg for males) along with low STAR values (\< 1 for females and \<1.4 for males). Sociodemographic data of the patients and levels of total protein, albumin, and 25-OH-vitamin D3 (25\[OH\]D) were obtained from all the patients. The BMD (bone mineral density) and T-scores of the proximal femur were measured using DXA (dual-energy X-ray absorptiometry).

Primary Outcome Measures: Bone Mineral Density (g/cm2), Non-fracture proximal femur neck BMD (g/cm2) was obtained using the same DXA (Stratos DR (DMS), Mauguio, France), baseline|Sonographic Thigh Adjustment Ratio (STAR) value, The study used the standard sonographic thigh adjustment ratio values of 1.0 for female patients and 1.4 for male patients. These values are found by dividing the thickness of the anterior thigh muscle (in mm) by the person's body mass (in kg/m2)., baseline|T-scores, A non-fracture proximal femur neck T score was obtained using the same DXA and is classified as normal if their T score exceeds -1 standard deviation (SD), as osteopenic if it falls between -2.5 SD and -1 SD, and as osteoporotic if it equals or falls below -2.5 SD., baseline
Secondary Outcome Measures: 25[OH]D levels, baseline|Albumin levels, baseline|Protein levels, baseline
Safety and Efficacy Study of Zamtocabtagene Autoleucel (MB-CART2019.1) in Pediatric Patients With Relapsed or Refractory B-Cell Neoplasms
NCT Number: NCT06508931
Acronym: DALY PED
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: PHASE2
Conditions: B-Cell Neoplasm
Interventions: DRUG: zamtocabtagene autoleucel (MB-CART2019.1)
Sponsor: Miltenyi Biomedicine GmbH
Sex: ALL
Age: CHILD
Enrollment: 31
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2025-04-01
Completion Date: 2029-10-01

Summary:
This is a single-arm, multi-center, open-label Phase II study to determine the safety and efficacy of MB-CART2019.1 in pediatric and adolescent subjects (aged between 6 months and \<18 years, ≥6 kg body weight \[BW\]) with mature B-cell neoplasms and aggressive lymphomas that relapsed after or are refractory to one or more prior therapies, including subjects with primary refractory disease.

Primary Outcome Measures: BORR, Best Overall Response Rate, The primary efficacy outcome of this study is BORR, defined as the proportion of subjects with at least one partial response (PR) or complete response (CR) from MB-CART2019.1 infusion until progressive disease (PD), start of new anti-lymphoma therapy, lost to follow-up or death, whichever occurs first., From infusion until week 78|Type, frequency, and severity of adverse events (AEs), serious adverse events (SAEs), and adverse events of special interest (AESI) [Safety and toxicity of the study product], The primary safety outcome of this study is to evaluate the incidence, type, frequency, and severity of adverse events (AEs), serious adverse events (SAEs), and adverse events of special interest (AESI) associated with the study product., From infusion until week 78
The Effect of Central Sensitization in Radicular Pain in Patients With Failed Low Back Surgery Syndrome
NCT Number: NCT06508918
Status: COMPLETED
Study Type: OBSERVATIONAL
Conditions: Herniated Disc|Failed Back Surgery Syndrome
Interventions: DRUG: Betametasona
Sponsor: Marmara University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 1
Study Design: Observational Model: |Time Perspective: p
Start Date: 2023-04-15
Completion Date: 2024-05-15
Locations: Mamara Üniversitesi Tıp Fakültesi, Istanbul, Turkey|Marmara University Pendik Training and Research Hospital, Istanbul, Turkey

Summary:
The Effect of Central Sensitization in Radicular Pain in Patients with Failed Low Back Surgery Syndrome on Treatment Success of Ultrasound-Guided Caudal Epidural Steroid Injection

Primary Outcome Measures: Numeric Rating Scale /NRS, At least 50 percent improvement in Numeric Rating Scale (NRS more than fifty percent reduction indicates greater improvement. The nrs score is scored from 0 to 100. Higher scores are associated with more pain.), 3rd months
Secondary Outcome Measures: Improvements in Douleur Neuropathique 4 Questions, Douleur Neuropathic 4 (DN4) is a scale that evaluates the patient's neuropathic symptoms with 4 questions. On the scale with a total score of 10, those who score above 4 indicate the presence of neuropathic pain., 3rd month|Improvements in Beck's Depression Inventory, Beck Depression Inventory the questionnaire consists of a total of 21 questions, each with four options. The total score is calculated by scoring each option in the range of 0-3. In scoring, 0-9 is interpreted as normal, 30-63 as severe depression., 3rd month|Improvements in Oswestry Disability Index, The Oswestry Disability Index the maximum score is "100", the minimum score is "0". As the total score increases, the level of disability also increases, 3rd month|Improvements in Central Sensitization inventory, scored between 0-100 points. The higher the patient's score, the more CS-related symptoms are considered to be., 3rd month|Improvements in Pressure Pain Thresold values, The value at which the feeling of pressure turns into a feeling of pain was recorded with a manual algometer. If patients fail to report pain at a pressure of 10 kg/cm2 on pressure pain threshold (PPT) measurements, the test will be stopped and this value will be recorded as PPT., 3rd month
Sleep Buddy Application in Hospitalized Children
NCT Number: NCT06508905
Status: ACTIVE_NOT_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Main Heading (Descriptor) Terms
Interventions: OTHER: Sleep buddy
Sponsor: Istanbul Medipol University Hospital
Sex: ALL
Age: CHILD
Enrollment: 97
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Start Date: 2023-06-01
Completion Date: 2024-09-15
Locations: Medipol University, Istanbul, Beykoz, 34810, Turkey

Summary:
The study was planned as a randomized controlled experimental study to investigate the effect of sleep companion application on psychosocial symptoms in hospitalized school children aged 6-12 years.

Primary Outcome Measures: Psychosocial symptoms diagnostic scale, Determination of psychosocial symptoms of hospitalized children The highest score that can be obtained from the scale is "48" and the lowest score is "0". A high score on the scale means that the hospitalized school child has psychosocial problems., Used 3 days after the sleep companion app. The scale administration took 15 minutes.
Does Occlusive Hydrocolloid Silver-containing Wound Dressing After Sternotomy Reduce Surgical Side Infection After Cardiac Surgery?
NCT Number: NCT06508879
Acronym: OHSCWD
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Surgical Site Infection; Cardiac Surgery; Advanced Dressing; Postoperative Care
Interventions: COMBINATION_PRODUCT: Aquacel Ag Surgical®|OTHER: Standard Care (sterile gauze and adhesive tape)
Sponsor: University Medical Center Mainz
Collaborators: German Research Foundation
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 352
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Start Date: 2018-01-01
Completion Date: 2019-08-31
Locations: Department of Cardiovascular Surgery, University Hospital of Johannes Gutenberg University Mainz, Mainz, Rheinland-Pfalz, 55131, Germany

Summary:
Wound healing disorders are a major problem in cardiac surgery. They prolong the inpatient stay and are associated with a high health and, above all, psychological burden for patients. They also represent a major organizational, medical and financial challenge for the treatment team. There is therefore still a great need for effective prevention of wound healing disorders. It goes without saying that wound management plays a major role in the development of wound healing disorders. Nowadays, there are a large number of products from various manufacturers and studies for efficient wound healing disorder prophylaxis. One point of criticism is that most of the existing studies are financed by the manufacturer. Due to the otherwise broad range of applications for all wounds in various specialist areas, it remains to be clarified whether such products can achieve a reduction in the rate of wound healing disorders, especially in cardiac surgery. After extensive literature research, we are of the opinion that the Aquacel Surgical Ag dressing, a new silver-coated hydrocolloid dressing, can be offered to cardiac surgery patients at our clinic as an effective prophylaxis against wound healing disorders.The study is a randomized prospective clinical trial. It is being conducted at the Clinic for Cardiothoracic and Vascular Surgery and has already been approved by the Rhineland-Palatinate Ethics Committee. The study should include 440 heart patients and last for 12 months. It will compare the Aquacel Surgical Ag bandage against our conventional methods. This study is being conducted independently of the industry. We want to prove that an intelligent investment in the prophylaxis of wound healing disorders is worthwhile for both patients and the clinic. If the outcome of the study is positive, this dressing will be be used regularly in our cardiac surgery clinic.

Primary Outcome Measures: SSI rate, overall rate of incidence of any kind of SSI, 30 days
Secondary Outcome Measures: dressing changes, 7 days|severity of SSI, 30 days|need for treatment, 30 days
Timing And Typology of ConducTIon disturbanCes During TAVI
NCT Number: NCT06508866
Acronym: TACTIC-TAVI
Status: RECRUITING
Study Type: OBSERVATIONAL
Conditions: Aortic Stenosis, Severe
Sponsor: Istituto Clinico Humanitas
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 490
Study Design: Observational Model: |Time Perspective: p
Start Date: 2023-02-01
Completion Date: 2024-12-31
Locations: IRCCS Istituo Clinico Humanitas, Rozzano, Milano, 20089, Italy

Summary:
The TACTIC-TAVI registry aims to collect information about a consecutive cohort of patients undergoing transcatheter aortic valve insertion. The registry is international, multi-centre and observational. The registry is planned to continue until the calculated sample size is achieved.

Primary Outcome Measures: Prediction of new requirement for permanent pacemaker after TAVI, The primary focus of the registry is evaluating which patient characteristics and conduction disturbances may help to predict the new requirement for permanent pacemaker after TAVI., 0-24 months