Real-world Experiences of Alcohol and Cognitions Over Time
NCT Number: NCT06579521
Acronym: REACT
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Alcohol Intoxication
Interventions: OTHER: Alcohol
Sponsor: University of Washington
Collaborators: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Sex: ALL
Age: ADULT
Enrollment: 100
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Start Date: 2024-08
Completion Date: 2025-08
Locations: University of Washington, Seattle, Washington, 98195, United States

Summary:
The goal of this clinical trial is to examine how alcohol affects young adults' attention in both laboratory and real-world settings through phone-based cognitive tasks. The main questions this trial is designed to answer are:

* How well do the phone-based cognitive tasks capture alcohol's effects on attention?
* Does the effect of alcohol on attention contribute to risk-taking?

Participants will complete cognitive tasks to assess attention before and after consuming a standard amount of alcohol in the laboratory, and during surveys completed through a phone app for eight weekends.

Primary Outcome Measures: Central Counting Task (phone), On a phone, participants will count the number of times a crosshair flashes in the center of the screen. Each trial will include between 1 and 4 flashes. There will be 6 trials per block. After a training block, there will be two blocks administered while sober. After alcohol consumption, three blocks will be administered on the ascending limb of the BrAC curve. Number of accurate responses will be evaluated., Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)|Peripheral Probe Identification Task (phone), While counting the number of times a crosshair flashes in the center of a phone screen (central counting task), participants will also be asked to monitor a cued corner (if possible), and shown an array of four colored stimuli. In each trial, they will be asked to identify whether the color of a probe matches the cued stimulus, with a 50% likelihood of matching. After a training block, there will be two blocks administered while sober. After alcohol consumption, three blocks will be administered on the ascending limb of the BrAC curve. Number of accurate responses will be evaluated., Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)|Visual Categorization Task (phone), On a phone, participants will be presented with one of two visual stimuli (shapes) in a random sequence with equal probability, and asked to categorize each stimuli as quickly as possible (e.g., "Is this a square or circle?") with placement of response buttons (right or left side of screen) randomized. Each trial consists of a shape categorization. There are 12 trials per block. After a training block, there will be two blocks administered while sober. After alcohol consumption, three blocks will be administered on the ascending limb of the BrAC curve. Differences in response time will be evaluated for one-back stimuli (change vs. no change) and two-back stimuli (change vs. no change)., Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)
Secondary Outcome Measures: Central Counting Task (desktop), On a phone, participants will count the number of times a crosshair flashes in the center of the screen. Each trial will include between 1 and 4 flashes. A training block of 12 trials will be administered while sober. After alcohol consumption, two blocks of 120 trials each will be administered on the ascending limb of the BrAC curve. Number of accurate responses will be evaluated., Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)|Peripheral Probe Identification Task (desktop), While counting the number of times a crosshair flashes in the center of a desktop screen (central counting task), participants will also be asked to monitor a cued corner (if possible), and shown an array of four colored stimuli. In each trial, they will be asked to identify whether the color of a probe matches the cued stimulus, with a 50% likelihood of matching. A training block of 12 trials will be administered while sober. After alcohol consumption, two blocks of 120 trials each will be administered on the ascending limb of the BrAC curve. Number of accurate responses will be evaluated., Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)|Auditory Categorization Task (desktop), On a desktop, participants will be presented with one of two auditory stimuli (high and low tones) in a random sequence with equal probability, and asked to categorize each stimuli as quickly as possible with placement of response options (shown on right or left side of screen) randomized. Each trial consists of a shape categorization. A training block of 12 trials will be administered while sober. After alcohol consumption, five blocks of 100 trials each will be administered on the ascending limb of the BrAC curve. Differences in response time will be evaluated for one-back stimuli (change vs. no change) and two-back stimuli (change vs. no change)., Baseline and after alcohol consumption in the laboratory (an average of approximately 1 hour after baseline)