Idiopathic Bilateral Vestibulopathy: Peripheral Vestibular Disorders and Their Repercussions
NCT Number: NCT06476587
Acronym: VBI
Status: ACTIVE_NOT_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Idiopathic Bilateral Vestibulopathy
Interventions: OTHER: Assessment of postural stability and active motion perception|OTHER: Cognitive tests|OTHER: Eccentric axis rotation|OTHER: Osteodensitometry|OTHER: Posturography|OTHER: Vestibulo-sympathetic regulation test|OTHER: Sleep quality assessment|OTHER: Representation of space and time assessment|OTHER: Influence of vestibular information on the bodily self-consciousness|OTHER: 3 Tesla MRI
Sponsor: University Hospital, Caen
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 70
Study Design: Observational Model: |Time Perspective: p
Start Date: 2022-10-05
Completion Date: 2024-12-31
Locations: UMRs 1075 COMETE Unicaen INSERM, Caen, Calvados, 14000, France

Summary:
The goal of this exploratory study is to gain a better understanding of the symptomatology of idiopathic bilateral vestibulopathy (IBV) by characterising as precisely as possible the type and intensity of each patient's peripheral vestibular deficit, and to investigate the link between this symptomatology and some functions influenced by the vestibular system (i.e. cognitive, emotional, vegetative functions).

Primary Outcome Measures: Center of pressure (CoP) path length, Stabilometric data: Total length travelled by the CoP (in mm), Posturography is assessed once, during about 30 minutes.|Center of pressure (CoP) path amplitude, Stabilometric data: Maximal distance over two points of the stabilogram (in mm), Posturography is assessed once, during about 30 minutes.|Center of pressure (CoP) surface area, Stabilometric data: surface travelled by the CoP (in mm²), Posturography is assessed once, during about 30 minutes.|Ocular torsion, During eccentric axis rotation: measure of the torsion of the eyes (in degree), Unilateral utricular otolith function is assessed once, during about 30 minutes|Duration estimate, During the time perception task, subjects are asked to estimate several durations (in seconds)., Time perception task is completed once, during about 30 minutes.|Duration production, During the time perception task, subjects are asked to produce several durations (in seconds)., Time perception task is completed once, during about 30 minutes.|Number of correct tandem steps, During tandem stance and walk, subjects are asked to stand upright in a heel-to-toe fashion with their arms crossed on their chest and walk., Assessment of postural stability and active motion perception is completed once, during about 30 minutes|Deviation distance (Fukuda stepping test), During the Fukuda stepping test, subjects are asked to take 50 steps on the spot, on a mat, with their eyes closed and their arms outstretched in front of them. Deviation distance is measured in cm., Assessment of postural stability and active motion perception is completed once, during about 30 minutes|Deviation angle (Fukuda stepping test), During the Fukuda stepping test, subjects are asked to take 50 steps on the spot, on a mat, with their eyes closed and their arms outstretched in front of them. Deviation angle is measured in degrees., Assessment of postural stability and active motion perception is completed once, during about 30 minutes|Hippocampal volume, Images of hippocampus are acquired by MRI, MRI exam is completed once, during about 1 hour|Brain activation during functional tasks, Images of the brain when participants are performing cognitive tasks (mental rotation task, prediction task) are acquired by functional magnetic resonance imaging (fMRI), MRI exam is completed once, during about 1 hour
Secondary Outcome Measures: Center of pressure (CoP) standard deviation - Anteroposterior, Stabilometric data: Standard deviation of the CoP position in the anteroposterior axis (in mm), Posturography is assessed once, during about 30 minutes.|Center of pressure (CoP) standard deviation - Mediolateral, Stabilometric data: Standard deviation of the CoP position in the mediolateral axis (in mm), Posturography is assessed once, during about 30 minutes.|Duration of the word reading in the congruent condition, Stroop color and word test : time spent to read the words in the congruent condition (in seconds), Cognitive functions are assessed once, during about 30 minutes|Duration of the colour naming, Stroop color and word test : time spent to name the colours (in seconds), Cognitive functions are assessed once, during about 30 minutes|Duration of the word reading in the incongruent condition, Stroop color and word test : time spent to read the words in the incongruent condition (in seconds), Cognitive functions are assessed once, during about 30 minutes|Trail making test part A, Paper and pencil Trail Making Test: Time spent by the subject to draw a line between numbers from 1 to 25 (in seconds), Cognitive functions are assessed once, during about 30 minutes|Trail making test part B, Paper and pencil Trail Making Test: Time spent by the subject to draw a line between numbers and letters (1-A, 2-B, etc.) (in seconds), Cognitive functions are assessed once, during about 30 minutes|Digit span during dual-task, Number of digits correctly recalled during the Baddeley's dual-task, Cognitive functions are assessed once, during about 30 minutes|Number of sequences correctly recalled, In the simple and dual conditions of the Baddeley's dual-task, Cognitive functions are assessed once, during about 30 minutes|Spatial span, Number of blocks correctly recalled during the Corsi task, Cognitive functions are assessed once, during about 30 minutes|Estimation of the duration of rotation, During the Perception of the amplitude and duration of rotations task, subjects seated in a rotating chair are asked to estimate the duration of the rotations (in seconds), Perception of the amplitude and duration of rotations task is completed once, during about 30 minutes.|Estimation of the amplitude of rotation, During the Perception of the amplitude and duration of rotations task, subjects seated in a rotating chair are asked to estimate the amplitude of the rotations (in degree), Perception of the amplitude and duration of rotations task is completed once, during about 30 minutes.|Deviation distance (Triangle completion task), During the triangle completion task, the participant will wear a blindfold and a noise-cancelling headphones. Guided by the experimenter, who will hold them by the shoulders, they will walk along the first two sides of a triangle. The participant will then have to turn on their own and walk along the third side to get back to the starting point. The deviation distance is measured in cm., Assessment of postural stability and active motion perception is completed once, during about 30 minutes|Deviation angle (Triangle completion task), During the triangle completion task, the participant will wear a blindfold and a noise-cancelling headphones. Guided by the experimenter, who will hold them by the shoulders, they will walk along the first two sides of a triangle. The participant will then have to turn on their own and walk along the third side to get back to the starting point. The deviation angle is measured in degree., Assessment of postural stability and active motion perception is completed once, during about 30 minutes