Pregnancies Outcomes in Advanced Maternal Age Women
NCT Number: NCT06528340
Acronym: POIAMA
Status: NOT_YET_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Advanced Maternal Age Pregnancy|Premature|Labor Complication|Delivery Complication|Delivery Complications Affecting Fetus / Newborn|Delivery;Complicated;Liveborn|Cesarean Section Complications|Complication of Labor and Delivery
Interventions: PROCEDURE: spontaneous delivery
Sponsor: Centro di Ricerca Clinica Salentino
Sex: FEMALE
Age: ADULT
Enrollment: 1000
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-09-01
Completion Date: 2026-03-30
Locations: Ospedale Veris delli Ponti, Scorrano, Lecce, 73020, Italy

Summary:
Pregnancies occurring in advanced maternal age (AMA) have become more common over the last few decades for a variety of reasons. Prominent contributor to this trend are the significant advancement in assisted reproductive technology (ART) and the growing accessibility to egg donation. Delaying having children is generally associated with other variables, such as the availability of various forms of contraception, which have decreased the number of unintended births and given women more autonomy over when they choose to become pregnant. In addition, from a socioeconomic standpoint, greater education and career options for women are major contributors to this phenomenon. Women with postsecondary education are especially affected by this issue since they are more likely to miss out on professional opportunities, money, and social standing when they become mothers. Studies show that women with a tertiary level of education stay pregnant later in life, compared to women with a lower level of education. Moreover, severe economic volatility throughout the early adult years, delays in the establishment of partnerships and marriages, and the shift from family homes to independent living all serve to worsen the tendency. In this investigation, we will seek, with a critical eye, to evaluate the implications of a pregnant woman in AMA and her outcomes, trying to highlight all the possible complications and problems of a pregnancy in AMA, with an evaluation of a big volume of AMA women in pregnancy and at delivery.

Primary Outcome Measures: Pregnancy outcomes, To investigate outcomes of pregnancies in advanced maternal age, in relation to maternal morbidity, as complications in pregnancy, gestational age at delivery, type of delivery, maternal pregnancy complications, placental pathology, peripartum hemorrages, duration of hospital stay, prolonged hospitalization, peripartum major complications, etc, 1 year
Secondary Outcome Measures: Perinatal outcomes, The results of this study will show whether maternal age has a significant association with preterm birth., 1 year|Perinatal outcomes, The results of this study will show whether maternal age has a significant association with low birth weight, 1 year|Perinatal outcomes, The results of this study will show whether maternal age has a significant association with low fifth-minute Apgar score, 1 year|Perinatal outcomes, The results of this study will show whether maternal age has a significant association with perinatal death., 1 year
Other Outcome Measures: Outcomes based on type of conception, To evaluate if the pregnancy outcomes in AMA women differ in relation to conception (if spontaneous, or by IVF/ET, by IVF/DO/ET or by CRYO)., 1 year