Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
NCT Number: NCT06458153
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Stroke|Cerebellum
Interventions: BEHAVIORAL: Neural responses to speech functional localizer|BEHAVIORAL: Neural responses to silent articulation|BEHAVIORAL: Neural responses to self vs. externally generated speech|BEHAVIORAL: Event-related potentials for speech|BEHAVIORAL: Neural responses to induced speech errors|BEHAVIORAL: Neural responses to sensory-motor adaptation|BEHAVIORAL: Speech production behaviors|BEHAVIORAL: Auditory acuity testing|BEHAVIORAL: Neural responses to learning a non-speech auditory motor behavior
Sponsor: University of Pittsburgh
Collaborators: Northwestern University|National Institute on Deafness and Other Communication Disorders (NIDCD)
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 100
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Start Date: 2024-07
Completion Date: 2028-07
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, United States

Summary:
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:

1. What regions of the brain's sensory systems show changes in their activity related to speech?
2. To what extent do these regions help listeners detect and correct speech errors?
3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?

Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).

Primary Outcome Measures: Blood oxygenation level dependent (BOLD) responses to self vs. externally generated speech, The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for the LISTEN-SELF vs. PRODUCE and LISTEN-OTHER vs. PRODUCE conditions. Encoding models will predict activity in regions-of-interest (ROIs) based on a set of speech features., One session lasting 2-3 hours, within 12 months of enrollment|BOLD responses related to pre-speech auditory modulation, The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses to auditory stimuli across conditions (e.g., SPEAK, REHEARSE, PLAN, SILENT)., One session lasting 2-3 hours, within 12 months of enrollment|EEG responses to self vs. externally generated speech, The dependent variables are evoked responses, aligned to sound onset, measured with EEG during task performance. We will contrast evoked responses across conditions (e.g., TALK, LISTEN)., One session lasting 2-3 hours, within 12 months of enrollment|BOLD responses to induced auditory errors, The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will determine activations in regions of interest that correlate with applied perturbations during speech. We will also compare SPEAK vs. LISTEN activations in perturbed and unperturbed conditions., One session lasting 2-3 hours, within 12 months of enrollment|BOLD responses during adaptation to auditory perturbations, The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses during the HOLD and BASELINE phases of the adaptation paradigm. We will determine areas where activation is associated with changes in formant frequencies in early and late windows in speech recordings., One session lasting 2-3 hours, within 12 months of enrollment|BOLD responses during learning of non-speech auditory motor targets, The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses during PRESS trials across runs. We will contrast LISTEN vs. PRESS trials to measure motor induced sensory modulation., One session lasting 2-3 hours, within 12 months of enrollment
Secondary Outcome Measures: BOLD responses to speech listening task, The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations for the SPEECH vs. signal correlated noise (SCN) and SPEECH vs. SILENT conditions., One session lasting 2-3 hours, within 12 months of enrollment|BOLD responses to silent articulation task, The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations for silent articulation vs. a resting baseline condition., One session lasting 2-3 hours, within 12 months of enrollment|Speech formant frequencies, We will measure participant-specific phonetic variables (formant frequencies) based on participant speech from reading passages and word production., First session lasting 2-3 hours, within 12 months of enrollment|Spontaneous Speech Synchronization Index, We will measure the Spontaneous Speech Synchronization Index based on behavioral speech data., First session lasting 2-3 hours, within 12 months of enrollment|Auditory acuity, We will measure auditory acuity (just noticeable difference) for changes in formant frequencies based on behavioral speech samples., First session lasting 2-3 hours, within 12 months of enrollment