pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Efficacy of VR Based Sword Fighting Exercises to Improve Upper Body Movements in Hemiplegic Patients
NCT Number: NCT06459570
Status: ACTIVE_NOT_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Hemiplegic Gait
Interventions: BEHAVIORAL: Virtual reality based exercises|OTHER: standard physical therapy
Sponsor: Superior University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 62
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Start Date: 2023-10-01
Completion Date: 2024-09-30
Locations: Azra Naheed Medical College, Superior University, Lahore, Punjab, Pakistan

Summary:
this thesis endeavors to shed light on the efficacy of VR-based sword-fighting exercises as a rehabilitation tool for improving upper body movement in hemiplegic patients.

Primary Outcome Measures: Fugl-Meyer Assessment of upper limb (FMA), This measures upper limb impairment and scores from 0 to 66, the higher the score, the less the impairment. The Fugl-Meyer Assessment (FMA) is a stroke-specific, performance-based impairment index. It is designed to assess motor functioning, balance, sensation, and joint functioning in patients with post-stroke hemiplegia., 12 Months|Action Research Arm Test (ARAT), This measures arm and hand function and ranges from 0 to 57, the higher the score, the better the upper limb function. The ARAT is a 19-item measure divided into 4 sub-tests (grasp, grip, pinch, and gross arm movement). Performance on each item is rated on a 4-point, 12 months
Management of Pediatric Distal Radius Fractures : Conservative Treatment Versus Surgical Reduction
NCT Number: NCT06459557
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Fracture, Radius
Interventions: PROCEDURE: cast|PROCEDURE: surgical reduction
Sponsor: Assiut University
Sex: ALL
Age: CHILD
Enrollment: 52
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2024-07-01
Completion Date: 2026-04-01

Summary:
To compare functional and radiological assessment between two groups of children with displaced distal radius fractures : those who will receive surgical reduction and those who will not.

Primary Outcome Measures: mean difference of Modifed the Disabilities of the Arm, Shoulder and Hand (m-DASH) score between the two groups, functional assessment at 1.5 , 3 , 6 and 12 months posttrauma using the Modifed the Disabilities of the Arm, Shoulder and Hand (m-DASH) score as (50/50) (100%) is considered the maximum value which is the best outcome and (10/50) (0%) is considered the minimum value which is the worst outcome, 12 months
Secondary Outcome Measures: Comparing palmar tilt angle between the 2 groups ., radiological assessment poattraumatic at 1.5 , 3 , 6 ,12 months for lateral view of wrist joint for the 2 groups comparing palmar tilt angle which is the angle formed by a line drawn perpendicular to the axis of the radial shaft, and a line that passes through the tips of the dorsal and volar rims (i.e. along the radius articular surface), 12 months|Comparing radial inclination between the 2 groups, radiological assessment posttraumatic at 1.5 , 3 , 6 ,12 months for anterioposterior view of wrist joint for the 2 groups comparing radial inclination which is the angle between a line drawn perpendicular to the long axis of the radius along the articular surface of the distal radius and a line drawn down from the tip of the radial styloid, 12 months|Comparing radius length between the 2 groups, radiological assessment posttraumatic at 1.5 , 3 , 6 ,12 months for anterioposterior view of wrist joint for the 2 groups comparing radius length which is the distance between two lines drawn perpendicular to the long axis of the radius on the AP projection from the apex of the radial styloid and level of the ulnar aspect of the articular surface, 12 months
Effects of Bobath Approach With Core Stability to Improve Balance in Stroke
NCT Number: NCT06459544
Status: ACTIVE_NOT_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Balance; Distorted
Interventions: DIAGNOSTIC_TEST: Bobath Technique with core stability|OTHER: Conventional treatment for balance
Sponsor: Superior University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 38
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Start Date: 2023-11-01
Completion Date: 2024-10-30
Locations: Naseer Hospital 16 A , AHMAD BLOCK NEW GARDEN TOWN, Lahore, Punjab, Pakistan

Summary:
Bobath technique with core stability exercises to improve balance in stroke. Randomized clinical trial study design will be followed. Data will be collected from following centers: Naseer Hospital, North Ravi Hospital, Bajwa Hoaspital,Minhaj Physiotherapy Centre, Home visits. Probability Random Sampling is used.

Primary Outcome Measures: Balance berg scale, Evaluates balance during a sequence of pre-planned tasks in an objective manner. It takes 20 minutes and consists of 14 tests. It is 5 points ordinal scale with 0 = lowest degree of function and 4 = highest level. The highest score is 14, 12 Months|Trunk Impairment Scale, Evaluate static and dynamic balance and trunk coordination.score goes from 0 = lowest performance and 23 = highest performance. Scores vary from 0 to 16., 12 months
Effect of VR VS Conservative Treatment in Sensorimotor Function of Upper Extremity in Chronic Stroke Patients
NCT Number: NCT06459531
Status: ACTIVE_NOT_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Chronic Stroke
Interventions: BEHAVIORAL: Virtual Reality (VR) Therapy|OTHER: Conservative Treatment
Sponsor: Superior University
Sex: ALL
Age: ADULT
Enrollment: 33
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Start Date: 2023-11-01
Completion Date: 2024-11-01
Locations: General hospital Jinnah hospital Mayo hospital Chaudhry Muhammad Akram Teaching and research hospital Services hospital Lahore (SHL), Lahore, Pakistan

Summary:
Virtual reality (VR) therapy has shown promising results in improving sensorimotor function of the upper extremity in chronic stroke patients compared to conservative treatments. VR offers immersive, interactive environments that can enhance motivation and engagement in rehabilitation exercises. Studies have indicated that VR can lead to significant improvements in motor function, coordination, and strength of the affected upper limb.

Primary Outcome Measures: Fugl-Meyer Assessment (FMA) for Upper Extremity, The Fugl-Meyer Assessment (FMA) for Upper Extremity is a widely used and validated tool to evaluate motor function, balance, sensation, and joint functioning in individuals who have had a stroke. It specifically assesses the sensorimotor function of the upper extremities., 12 Months|Stroke Impact Scale (SIS), The Stroke Impact Scale (SIS) is a self-report questionnaire that evaluates the impact of stroke on multiple dimensions, including strength, hand function, activities of daily living (ADL), mobility, communication, emotion, memory, thinking, and participation.

Scoring:

Each item is scored on a scale of 1 to 5:

1: Unable to do 5: Not difficult at all Higher scores indicate a lesser impact of stroke on the patient's life.

Usage in the Study:

Assessment Schedule: Administered at baseline and at the end of the intervention period.

Objective: To assess the overall impact of stroke on the patient's quality of life and participation in daily activities, 12 months
Effectiveness of Bowen Technique vs Muscle Energy Technique in Neck Pain.
NCT Number: NCT06459518
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Neck Pain|Musculoskeletal Manipulation
Interventions: OTHER: Bowen Therapy along with conventional therapy|OTHER: Muscle Energy Technique with Conventional Therapy
Sponsor: Riphah International University
Sex: ALL
Age: CHILD, ADULT
Enrollment: 36
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-06-15
Completion Date: 2024-09-26
Locations: Maryam Polyclinic Sahiwal, Sahiwal, Punjab, 57000, Pakistan

Summary:
Mechanical neck pain, also known as non-specific neck pain, is a prevalent ailment that results from problems with spine and surrounding tissue function. Trauma, degenerative changes, strained muscles, and bad posture are among the causes. The range of symptoms includes headaches, stiffness, and mild to severe pain. The goal of treatment is to strengthen the muscles and improve posture. The diagnosis is clinical. The Bowen Technique is a type of gentle bodywork therapy that promotes relaxation and overall rebalancing by using specific movements to activate the autonomic nerve system. It is sought for the improvement of general well-being, pain alleviation, and stress reduction. Patients undergoing manual treatment will be asked to actively contract their muscles against regulated resistance using the Muscle Energy Technique (MET). It addresses problems including joint limitations and attempts to return muscles and joints to their normal functions.

Primary Outcome Measures: Pain level, The Numeric Pain Rating Scale (NPRS) is a straightforward tool used to measure pain intensity in adults, including those suffering from chronic pain associated with rheumatic conditions. It features an 11-point scale, where '0' indicates no pain and '10' signifies the most extreme pain possible, described as "pain as bad as you can imagine" or "the worst pain imaginable.", 4th week|Functional Disability, A self-reported questionnaire called the Neck Disability Index (NDI) is used to gauge how neck pain affects a person's ability to function and go about their everyday life. It is divided into eleven sections that address different tasks such as sleeping, work, reading, lifting, and personal care. In each category, respondents rate the level of difficulty they encounter; scores are added together to produce a percentage that indicates the degree of disability. When conducting clinical assessments, the NDI is a useful instrument that helps medical practitioners determine the degree of functional limits and provide personalized interventions for patients with neck discomfort., 4th week
Puzzle Game Strategy on Older Adults
NCT Number: NCT06459492
Acronym: PUZZLEOLDER
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Old Age; Debility
Interventions: BEHAVIORAL: puzzle game strategies
Sponsor: Alexandria University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 70
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Start Date: 2023-11-01
Completion Date: 2024-04-30
Locations: Alexandria university, Alexandria, Al Iskandariyah, 21913, Egypt

Summary:
One innovative approach uses puzzle game strategies, including crosswords, Sudoku, and other brain-teasing activities. These strategies have been shown to help maintain attention, improve memory, and keep older adults' thoughts clear and sharp. Additionally, engaging in these activities can provide psychological benefits by offering a sense of achievement, reducing stress, and fostering social interactions.

Primary Outcome Measures: Older adults who participate in puzzle game strategies and cognitive functioning by Mental Health Scale (MHS), Older adults who participate in puzzle game strategies will exhibit lower cognitive difficulties by MHS (scores ranging from 0 to 10, with a higher score indicating lower cognitive difficulties) than those who do not enter intervention, three months
Conversational AI Study
NCT Number: NCT06459479
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Medical Education
Interventions: OTHER: Conversational Artificial Intelligence Simulations
Sponsor: Stanford University
Sex: ALL
Age: ADULT
Enrollment: 20
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Start Date: 2024-08-01
Completion Date: 2025-07-31

Summary:
This is a prospective, collaborative, mixed-methods study which includes anesthesiology trainees receiving one active intervention - a conversational artificial intelligence (CAI) simulation. The goal is to explore the capability of AI to provide high-fidelity simulations that can ultimately improve how healthcare professionals handle difficult conversations such as disclosing medical errors or mistakes.

Primary Outcome Measures: Evaluate acceptance of Conversational Artificial Intelligence Simulations using Guided Discussion Interview Question Guide, Guided Discussion Interview Question Guide contains 6 questions focusing 3 areas including Attitudes and Opinions, Perceptions and Summation question. All the questions are open-ended questions, Before simulation
Secondary Outcome Measures: Evaluation of Conversational Artificial Intelligence Simulations usability via the System Usability Scale (SUS), Measured with the System Usability Scale (SUS). The scale has 10 items. Scores ranges from 1-5 (1 = strongly disagree and 5 = strongly agree), Immediately after simulation|Evaluation of Conversational Artificial Intelligence Simulations usability via the User Experience Questionnaire (UEQ-S)., UEQ-S, includes eight items (four from the pragmatic scales Efficiency, Perspicuity, Dependability, and four from the hedonic scales Stimulation and Novelty). Scores range from -3 (min) to 3 (max), Immediately after simulation|Evaluation of the reliability of AI quantitative assessment of non-technical performance compared to expert human assessors, The Anaesthetist Non-Technical Skills (ANTS) tool previously published by Fletcher et al. translated in French. The ANTS scoring system uses four categories assessing task management, teamworking, situation awareness and decision-making (1 to 4 points by categories). The minimum score is 4 and the maximum 16, immediately after simulation
Effects of Kinesiotherapy Exercises With Cervical Mobilization in Cervicobrachial Neuralgia
NCT Number: NCT06459466
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Cervico-Brachial Neuralgia
Interventions: PROCEDURE: kinesiotherapy exercises with cervical mobilization|PROCEDURE: cervical Mobilization
Sponsor: Riphah International University
Sex: ALL
Age: ADULT
Enrollment: 30
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2023-11-23
Completion Date: 2024-07-01
Locations: IIMCT Railway General Hospital, Rawalpindi, Punjab, 46000, Pakistan

Summary:
To evaluate the effects of kinesiotherapy exercises with cervical mobilization in Cervicobrachial Neuralgia.

Primary Outcome Measures: Pain: Visual analogue scale (VAS), VAS is a psychometric instrument used to measure subjective characteristics or attitudes, typically pain intensity or other subjective experiences., 3 weeks
Secondary Outcome Measures: Range of Motion: Goniometer, It is an instrument used to measure angles, typically the range of motion of joints in the human body., 3 weeks
Other Outcome Measures: Cervical radiculopathy impact scale (CRIS), It is a 21-item self-reported questionnaire that is used to assess the impact of cervical radiculopathy on patients' daily lives. It is divided into three subscales:

* Symptoms (9 items)
* Energy and postures (6 items)
* Actions and activities (6 items), 3 weeks
Effects of Kaltenborn Versus Mulligan Techniques in Rheumatoid Arthritis.
NCT Number: NCT06459453
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Kaltenborn|OTHER: Mulligan
Sponsor: Riphah International University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 34
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2023-11-23
Completion Date: 2024-08-06
Locations: Shaikh zayed hospital, Lahore, Punjab, Pakistan

Summary:
This project was a randomized control trial conducted to check the effects of kaltenborn versus mulligan techniques on pain ,range of motion and functional disability in patients with rheumatoid arthritis of the wrist The inflammatory polyarthritis that primarily affects the tiny joints is a hallmark of rheumatoid arthritis, a chronic autoimmune illness. It is characterized by synovial joint degeneration, joint swelling, and joint discomfort, which can result in disability and early death .All patients of chronic stage,convenience sampling technique was used,subjects following eligibility criteria from Shaikh zayed hospital lahore ,were randomly allocated into two groups ,baseline assessment was done.Group A participants were given Kaltenborn mobilization along with conventional physiotherapy.Group B participants were given Mulligan mobilization along with conventional physiotherapy.Post intervention assessment was done via,VAS(visual analogue scale),goniometric measurements of wrist ranges,and QUICK DASH score.3 sessions per week were given,Data was analyzed by using SPSS.

Primary Outcome Measures: VAS(visual analogue scale), The visual analogue scale measures pain intensity .it consists of a 10cm line, with two end points representing 0 ('no pain')and 10('worst pain').The patient rate their current level of pain by placing a mark on the line. ., 4 weeks|GONIOMETER, Goniometer is an instrument used to determine range of motion in patients joint .During rehabilitation, a goniometer would also be used to measure what progress has been achieved in returning back to normal range of motion.In rheumatoid arthritis of the wrist , goniometer measures the range of flexion ,extension ,radial and ulnar deviation of the wrist joint ., 4 weeks|QUICK DASH, It is the 11 item questionnaire that measures upper extremity specific symptoms and disability. It can be used to access any region of the upper extremity. The first 6 items measure the degree of difficulty in performing various physical activities and the other five items related to quality of sleeping, social activities ,daily activities and the intensity of pain and numbness., 4weeks
Effect of Group-Task-Oriented Training on GMFM and ADL in Children With DS
NCT Number: NCT06459440
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Downs Syndrome
Interventions: BEHAVIORAL: Group Task oriented Training|OTHER: Routine Treatment
Sponsor: Riphah International University
Sex: ALL
Age: CHILD
Enrollment: 44
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Start Date: 2024-06-15
Completion Date: 2024-08-15
Locations: Riphah International University, Lahore, Punjab, 54700, Pakistan

Summary:
Down syndrome, a genetic condition resulting from an additional copy of chromosome 21, manifests with distinct facial features and intellectual challenges. Individuals with Down syndrome often face delays in motor skills, speech, and language development, alongside potential health issues. Down syndrome commonly encounter difficulties in both gross and fine motor functions due to factors like low muscle tone. Nonetheless, targeted interventions, including physical, significantly enhance motor skills. Daily living activities for individuals with Down syndrome cover personal care and household tasks, with structured routines and consistent support fostering independence. Group Task-Oriented Training, focusing on skill improvement and social interaction through collaborative activities, offers a meaningful approach to enhancing the overall quality of life for individuals with Down syndrome.

Primary Outcome Measures: GROSS MOTOR FUNCTION MEASURE, The Gross Motor Function Measure (GMFM) is a clinical tool used to assess gross motor function in individuals with cerebral palsy. It evaluates five dimensions: lying and rolling, sitting, crawling and kneeling, standing, and walking, running, and jumping. Each dimension has specific items reflecting developmental motor milestones. Scoring is based on observed abilities, ranging from 0 (no ability) to 3 (complete ability). The total score indicates the individual's overall gross motor function. The GMFM is valuable for tracking progress over time and guiding intervention strategies for those with cerebral palsy (23)., 6 weeks|Jebsen Hand function test, The Jebsen Hand Function Test (JHFT) is a clinical tool assessing hand function and fine motor skills in daily activities. Tasks include writing, card manipulation, and object handling. Widely used in rehabilitation, it measures speed and efficiency in completing tasks, aiding treatment planning for conditions affecting hand function. The JHFT demonstrates good reliability and validity, ensuring consistent and accurate assessment results, making it valuable for tracking progress and guiding interventions in individuals with upper extremity conditions, 6 weeks|Pediatric Evaluation of Disability Inventory (PEDI), The PEDI comprises three domains: self-care, mobility, and social function. Each domain evaluates specific tasks including feeding, dressing, walking, and communicating with others. It takes into consideration the child's age, developmental stage, and specific diagnosis., 6 weeks
Oropharyngeal Administration Of Colostrum For Preventing Necrotizing Enterocolitis in Preterrms
NCT Number: NCT06459414
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Prematurity
Interventions: OTHER: : Oropharyngeal Administration Of Colostrum
Sponsor: Cairo University
Sex: ALL
Age: CHILD
Enrollment: 96
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Start Date: 2024-04-15
Completion Date: 2024-08-17
Locations: Hoda Atef Abdelsattar Ibrahim, Cairo, Egypt

Summary:
Mother's milk samples will be collected during the routine expression of milk, using a hospital-grade electric breast pump, and will be stored in the NICU breastmilk refrigerator. The research doctor will prepare the syringes for the first 24 hours of the Initial Treatment Period. For neonates in the placebo group, the milk is immediately frozen, in a separate NICU breastmilk freezer to maintain blinding, for later use when enteral feedings are started. Using sterile gloves, oral syringes will be each filled with 1 mL/kg of colostrum or normal saline 0.9% (based on group assignment), capped, and covered with a white tape as a blinding procedure. Each syringe will be labeled with the patient's name, medical record number, and the date and time of preparation. Syringes will be prepared in the same sterile manner, by the research doctor, every 24 hours.

Primary Outcome Measures: The difference in hospital length of stay between preterm neonates who received colostrum for 3 days and those who did not receive it, Determination of possible protective effects of colostrum via assessing the hospital stay, 2 month
Serum Cystatin C for Early Detection of Acute Kidney Injury After Primary Percutaneous Coronary Intervention
NCT Number: NCT06459362
Status: NOT_YET_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: Serum cystatin C
Sponsor: Assiut University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 45
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-07-01
Completion Date: 2027-07-01

Summary:
This study aims to evaluate whether the serum levels of Cystatin C (CysC) can be used as early biomarkers for the identification of patients who are prone to AKI after cardiac interventional surgeries as primary percutaneous coronary intervention (PCI)

Primary Outcome Measures: prevention and screening for early detection of acute kidney injury, using serum levels of Cystatin C (CysC) as early biomarkers for the identification of patients who are prone to AKI after cardiac inteventional surgeries as primary percutaneous coronary intervention (PCI), 2 years
Effects of Sensory Stimulation Versus Sensorimotor Therapy on Spasticity, Motor Function and Daily Activities in Stroke
NCT Number: NCT06459349
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Stroke, Ischemic|Proprioceptive Disorders|Sensory Defect
Interventions: OTHER: exteroceptive and proprioceptive sensory stimulation training|OTHER: sensorimotor therapy group
Sponsor: Riphah International University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 42
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2024-04-01
Completion Date: 2024-09-01
Locations: Riphah International University, Islamabad, Fedral, 44000, Pakistan

Summary:
To compare effects of exteroceptive and proprioceptive sensory stimulation versus sensorimotor therapy on spasticity, motor function and activities of daily living in patients with stroke

Primary Outcome Measures: Fugl-Meyer Assessment, Fugl-Meyer Assessment:

It is designed to evaluate functional recovery after stroke and is based on the poststroke recovery sequence. The test evaluates 5 domains of upper limb, lower limb, balance, sensation, and range of motion in 155 items. The overall reliability was high (overall intraclass correlation coefficient = .96), and the intraclass correlation coefficients for the subsections of the assessment varied from .61 for pain to .97 for the upper extremity. Greater scores refer to improvement in limb functions, 6 months|Modified Barthel Index:, Modified Barthel Index:

It assesses the level of ability to perform daily activities. This questionnaire measures one's ability to perform different aspects of daily performance on a 0 to 100 scale, with higher scores indicating better performance. 0 to 20 scores are considered as complete dependency, 20 to 60 grades as severe dependency, 61 to 90 as moderate dependency, 91 to 99 as partial dependency and 100 as complete independence., 6 months|The Modified Ashworth Scale, The Modified Ashworth Scale is used to assess muscle spasticity. Spasticity using this scale, is the amount of muscle tone that scores between 0 and 4. Score 0 means no increase in tone; score

1 slight increase in muscle tone, with little resistance at the end of the flexion range or extension of involved limb; +1 score slight increase in muscle tone, characterized by slightly resistance at less than half the flexion or extension of involved limb; score 2 significant increase in muscle tone in most limb range;, score 3 significant increase in passive muscle tone, movement is difficult; and score 4 limb involved in flexion or extension rigidity., 6 months
Comparative Effects of Intensive and Distributed CIMT on Upper Extremity Function in Stroke Patients
NCT Number: NCT06459336
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Stroke
Interventions: OTHER: Intensive constraint-induced movement therapy|OTHER: Distributed constraint-induced movement therapy
Sponsor: Riphah International University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 50
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-03-01
Completion Date: 2024-08
Locations: Hameed Latif Hospital, Lahore, Punjab, 54000, Pakistan

Summary:
The main question this clinical trial is aims to answer is whether intensive and distributed constraint-induced movement therapy has similar effects on upper extremity function in participants with stroke. Participants will receive intensive protocol of CIMT for 6 hours for 6 days to make total of 36 hours while distributed protocol participants will receive 2.25 hours of training two times a week for 8 weeks making total of 36 hours.

Primary Outcome Measures: Fugl-Meyer Assessment-Upper Extremity, It is designed to assess reflex activity, movement control and muscle strength in the upper extremity of people with post-stroke hemiplegia. It consists of 30 items assessing motor function and 3 items assessing reflex function. The score most applicable to task performance is given from "0, inability," "1, beginning ability," to "2, normal" (total score range, 0-66)., 8th week|Wolf motor function test, This test was designed to assess the motor ability of patients with moderate to severe upper extremity motor deficits in the laboratory and clinic. The original version of this test was developed by Dr. Steven L. Wolf, Emory University School of Medicine. The original version consisted of 21 items; the widely used version of the wolf motor function test consists of 17 items. it uses a Uses a 6-point ordinal scale i.e."0" means "does not attempt with the involved arm" to "5" means "arm does participate; movement appears to be normal.", 8th week
the Outcomes of Laparoscopic Cholecystectomy for Acute Cholecystitis Within and Beyond the First 72 Hours, Does it Differ?!
NCT Number: NCT06459323
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Acute Cholecystitis
Interventions: PROCEDURE: Laparoscopic cholecystectomy
Sponsor: Assiut University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 20
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2025-03-01
Completion Date: 2026-05-01

Summary:
Compare outcomes of patients undergoing early laparoscopic cholecystectomy within and after72 hours of symptoms.

Primary Outcome Measures: Bile duct injury , intraoperative bleeding and operative time, Evaluate bile duct integrity, calculate amount of blood loss and operative time from the start till the end, One week
Pilot Study on Evaluating the Geroprotective Effect of Metformin
NCT Number: NCT06459310
Acronym: AGE-M
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: PHASE2
Conditions: Metformin|Aging
Interventions: DRUG: Metformin Hydrochloride tablet|DRUG: Placebo
Sponsor: Xuanwu Hospital, Beijing
Collaborators: Institute of Zoology, Chinese Academy of Sciences|Beijing Institute of Genomics, Chinese Academy of Sciences|Merck Serono Co., Ltd., China
Sex: MALE
Age: ADULT, OLDER_ADULT
Enrollment: 120
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Start Date: 2024-06-30
Completion Date: 2028-07-31
Locations: Xuanwu Hospital Capital Medical University, Beijing, China

Summary:
The objective of this research is to assess the efficacy of oral metformin in mitigating the aging process in middle-aged and elderly males, to pinpoint sensitive indicators of human senescence, and to offer innovative frameworks and scientific insights for pharmaceutical interventions in aging.

Primary Outcome Measures: Composite the efficacy of metformin in intervening aging, 1. Metformin delay aging related sensitive indicators (2), such as SA\*, ancient virus \*.
2. Metformin inhibits markers of inflammation in the body (4), such as C1 protein \*, CRP, CXCL9, TNFa.
3. Metformin improved immune cell-related indicators (10\*), such as T1/T2/L gene expression.
4. Metformin improves metabolism-related indexes (4), such as metabolic secretion factors APOX1\* and APOX2\*.
5. Age-related indicators have been published (5), such as telomere length, DNA methylation age, hormone levels, etc., Baseline - 12 month
Secondary Outcome Measures: Composite Through clinical physical examination data, behavioral indicators and multilevel omics data, to discover new sensitive biomarkers for evaluating aging., 1. Aging atlas-R, PBMC RNA profiling, \>5% DEGs.
2. Aging atlas-P, proteomic profiling, \>5% DEPs.
3. Aging atlas-M, metabolic profiling, \>5% metabolites.
4. Aging atlas-B, metagenomic profiling, \>5% microbiotas.
5. Reduce human biological age complex parameters., Baseline - 12 month
Instrument Tissue Interaction at the Grasp Site During Membrane Peeling of Epiretinal Membranes
NCT Number: NCT06459284
Status: ACTIVE_NOT_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Epiretinal Membrane
Interventions: OTHER: retrospective data analysis
Sponsor: Prim. Prof. Dr. Oliver Findl, MBA
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 55
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-06-03
Completion Date: 2024-12-31
Locations: Vienna Institute for Research in Ocular Surgery, Vienna, 1140, Austria

Summary:
Epiretinal membranes are a disease of the retinal surface, that may affect visual acuity and cause metamorphopsia. Using vitrectomy with membrane peeling, postoperative improvement of visual acuity and metamorphopsia may be achieved in a majority of patients. Diaz et al. demonstrated that there are postoperative changes in the "nerve fiber layer" after ILM peeling, but in that study, no recording of instrument/tissue interactions was performed using iOCT.

The aim of this study is to examine dipping into retinal tissue with the forceps during grasping of the epiretinal membrane at the starting point of peeling with iOCT.

Primary Outcome Measures: occurrence of dipping into retinal tissue with the ILM forceps during grasping, occurrence of dipping into retinal tissue during grasping will be evaluated (yes/no), during surgery, an average of 30 minutes|amount of dipping into retinal tissue with the ILM forceps during grasping, measured with ImageJ, amount of dipping into retinal tissue will be measured with calipers in ImageJ, during surgery, an average of 30 minutes
Secondary Outcome Measures: anatomical changes at the grasp site measured with optical coherence tomography, anatomical changes in retinal layers at the grasp site will be examinded by optical coherence tomography (yes/no), 3 months
Throwing Velocity and Patient Reported Outcomes in Elite Level Handball Players After Completion of Shoulder-Pacemaker Strength Training
NCT Number: NCT06459258
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Shoulder Dislocation
Interventions: OTHER: Motion-triggered NMES training protocol|OTHER: Non-Motion-triggered NMES training protocol
Sponsor: Sportorthopädie Zentrum in Wien Hietzing
Collaborators: Austrian Research Group for Regenerative and Orthopedic Medicine
Sex: MALE
Age: ADULT, OLDER_ADULT
Enrollment: 14
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Start Date: 2023-03-01
Completion Date: 2024-06-07
Locations: Sportorthopädie Zentrum, Wien, 11190, Austria

Summary:
The successful application of treatment protocols using motion-triggered neuromuscular electrical stimulation (NMES) for treatment-resistant functional posterior shoulder instability was recently demonstrated. The purpose of this study is to evaluate the concept of a motion-triggered NMES training protocol through objective clinical outcome parameters and its impact on external rotational (ER) shoulder strength and throwing velocity in healthy, elite-level handball players.

Primary Outcome Measures: Throwing velocity (km*h-1), the difference in throwing velocity (km\*h-1) from baseline to 6-week post-intervention follow-up., Baseline to 6-week post-intervention follow-up.
Secondary Outcome Measures: Isometric hand-held dynamometer (HHD) ER and internal rotation (IR) maximal shoulder strength, Secondary outcome was the difference in isometric hand-held dynamometer (HHD) ER and internal rotation (IR) maximal shoulder strength at final follow-up., Baseline to 6-week post-intervention follow-up
Resistance Training to Prevent Lymphedema After Breast Cancer Surgery Randomized Controlled Study
NCT Number: NCT06459245
Status: ENROLLING_BY_INVITATION
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Breast Cancer Female
Interventions: BEHAVIORAL: Resistance training
Sponsor: Yue WANG
Sex: FEMALE
Age: ADULT, OLDER_ADULT
Enrollment: 30
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Start Date: 2024-06-18
Completion Date: 2024-09-30
Locations: Peking University First Hospital, Beijing, China

Summary:
Breast cancer-related lymphedema is one of the most common chronic complications of breast cancer survivors. In existing studies, the reported incidence of lymphedema ranges from 2.5% to 42.9% . At present, there is no cure for lymphedema. Resistance training has been proved by many studies to alleviate the symptoms of lymphedema, improve the muscle strength of the upper limbs of patients, and improve the quality of life of patients, while not worsening lymphedema. Based on the best evidence, this study intends to construct resistance appropriate for this clinical scenario Training program: Conduct 3-month intervention for patients after breast cancer surgery to explore the effect of resistance training on the grip strength of the affected limb, the range of motion of the shoulder joint of the affected limb, the occurrence of lymphedema of the affected limb, quality of life, etc.

Primary Outcome Measures: Lymphedema occurrence, Tissue and local edema due to obstruction of lymphatic drainage, 3 months after intervention
Factors Determining Tolerance to Nasal Allergen Exposure With Advanced Age in a Subset of Birch Pollen Allergic Subjects
NCT Number: NCT06459219
Acronym: AllergyAge
Status: NOT_YET_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Allergic Rhinitis|Allergic Conjunctivitis
Sponsor: Sven Schneider, MD
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 152
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-10-01
Completion Date: 2028-10-01
Locations: Medical University of Vienna, Vienna, A-1090, Austria

Summary:
Nasal allergen study in patients aged 60+ with or without current respiratory allergy

Primary Outcome Measures: Nasal IgG4, To demonstrate that Bet v 1-specific nasal IgG4 responses 5 weeks after controlled nasal birch pollen provocation are significantly higher in subjects aged ≥60y without ongoing respiratory allergic symptoms with a history of allergy (group1) as compared to age-matched subjects currently suffering from allergic rhinoconjunctivitis (group 2)., 5 weeks
Accuracy of the EvieMED Ring Pulse Oximeter in Profound Hypoxia
NCT Number: NCT06459206
Status: RECRUITING
Study Type: OBSERVATIONAL
Conditions: Hypoxia
Interventions: DEVICE: Pulse oximeter
Sponsor: Movano Health
Collaborators: University of California, San Francisco
Sex: ALL
Age: ADULT
Enrollment: 12
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-06-11
Completion Date: 2024-06-13
Locations: Hypoxia Research Laboratory, San Francisco, California, 94133, United States

Summary:
The goal of this study was to evaluate the accuracy of pulse oximeters over the range of 70-100% per the International Organization for Standardization (ISO) 80601-2-61:2019. Four test devices were placed on each subject on the left or right hand with two at the finger base and two at the fingertip. Motion equipment was used to control motion of the test devices. In addition, two test devices were placed on the contralateral hand on the base of a finger and also on the fingertip. Finally, a test wrist device was placed on either the left or right wrist. SpO2 measurements from these devices were compared to sampling of arterial blood during brief stable oxygen desaturation in healthy volunteers to evaluate the claimed range.

Primary Outcome Measures: Test devices oxygen saturation accuracy, Root Mean Squared Error (RMSE) between test devices in motion and motionless saturation of peripheral oxygen and arterial oxygen saturation., 2 days
Trimetazidine Efficacy in Attenuating Paclitaxel-Induced Peripheral Neuropathy
NCT Number: NCT06459193
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: PHASE1|PHASE2
Conditions: Peripheral Neuropathy Due to Chemotherapy
Interventions: DRUG: Trimetazidine|DRUG: Placebo
Sponsor: Minia University
Sex: FEMALE
Age: ADULT, OLDER_ADULT
Enrollment: 60
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Start Date: 2024-06-23
Completion Date: 2024-11-30
Locations: Minia Oncology Center, Minya, 61512, Egypt

Summary:
This proof-of-concept study evaluated the effect of Trimetazidine on the incidence of paclitaxel-induced peripheral neuropathy in patients with breast cancer.

Primary Outcome Measures: Incidence of chemotherapy induced-peripheral neuropathy using National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) criteria, Number of patients reported neuropathy from paclitaxel. a 1 to 5 graded scale; where grade (1) is the minimum value and grade (5) is the maximum value, a greater grades mean greater symptomatic burden., weekly for up to 8 weeks|Patient's Quality of Life, measures the quality of life using the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity FACT/GOG-NTX (Version 4) questionnaire.

A total score ranging from 0 (minimum value) to 44 (maximum value), where lower scores mean greater symptomatic burden., at baseline, at the end of 4 weeks and at the end of 8 weeks
Secondary Outcome Measures: Changes in serum levels of biomarker namely nerve growth factor (NGF)., measuring serum level of nerve growth factor using enzyme-linked immunoassay (ELISA) Kit., at baseline and at end of 8 weeks|Adverse effects of using trimetazidine in preventing Paclitaxel Induced Peripheral Neuropathy., any adverse/ side effect will be evaluated., at baseline and weekly up to 8 week|Severity of chemotherapy induced-peripheral neuropathy., The severity of paclitaxel-induced peripheral neuropathy using VAS visual analogue scale.

a 10-cm line that represents a continuum between "no pain" and "worst pain.", at baseline, at the end of 4 weeks and at the end of 8 weeks
Position Intervention to Reduce Hypoxemia in Sedation Patients
NCT Number: NCT06459167
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Hypoxemia|Sedation Complication|Emergencies|Airway Remodeling
Interventions: OTHER: The position adopted when patients undergoing procedure or surgery
Sponsor: First Affiliated Hospital of Zhejiang University
Collaborators: Zhejiang Provincial Tongde Hospital|Shenzhen Second People's Hospital|Zhejiang Provincial People's Hospital|The Sixth Affiliated Hospital of Wenzhou Medical University|Lishui Municipal Central Hospital|Ningbo No. 1 Hospital|Zunyi Medical College|The First Affiliated Hospital of Zhengzhou University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 1752
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Start Date: 2024-06-20
Completion Date: 2026-06-30
Locations: The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310000, China

Summary:
Hypoxemia was defined as an SpO2 of \< 90% for any duration. Failure to treat promptly can lead to hypoxemia, which may increase the risks of arrhythmia, nausea and vomiting, and cognitive dysfunction. Studies have shown that body position has a direct impact on respiratory function. In special environments, including outside the operating room where emergency airway management for critically ill and injured patients is needed, or in areas with limited medical resources like remote areas, adopting simple interventions by changing position to maintain patients' respiratory function can be more economical, convenient and safe.

Primary Outcome Measures: The lowest SpO2, The lowest SpO2 during sedation and procedures, During procedure|Use of airway interventions, Use of airway interventions including increased inhaled O2, ventilated mask and endotracheal intubation, During procedure
Secondary Outcome Measures: The onset of when SpO2 dropped below 80%, The onset of when SpO2 reached below 80%, During procedure|The onset of when SpO2 dropped below 70%, The onset of when SpO2 reached below 70%, During procedure|The onset of respiratory adverse events, The onset of respiratory adverse events including apnea, laryngospasm, aspiration due to regurgitation, During procedure|The onset of circulatory adverse events, The onset of circulatory adverse events including hypotension, hypertension, bradycardia, tachycardia, new-onset arrhythmia with hemodynamically stable/instability, cardiac arrest, shock, During procedure|The onset of gastrointestinal adverse events, The onset of gastrointestinal adverse events including nausea and vomiting, regurgitation, During procedure|The degree of operator satisfaction, The degree of operator satisfaction regarding the performance, effectiveness, and experience of a procedure. A 10-point scale is used, 0 indicates complete dissatisfaction and 10 indicates complete satisfaction., During procedure
The Effectiveness of Mixed Reality as Interventional Tool for the Improvement on Quality of Life for People With Parkinson´s Disease.
NCT Number: NCT06459154
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Parkinson Disease
Interventions: OTHER: Mixed Reality|OTHER: Traditional Physiotherapy
Sponsor: University of Nicosia
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 15
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2023-08-20
Completion Date: 2025-12-20
Locations: University of Nicosia, Nicosia, Engomi, 2408, Cyprus

Summary:
Parkinson's disease is a chronic, neurodegenerative disease of unknown cause, affecting elderly people over the age of 60. It is the second most common neurodegenerative disease, presenting psychomotor signs and symptoms that lead to impaired functionality and quality of life in affected individuals. Mixed reality involves the delivery of digital stimuli in real time and space through spatial mapping using glasses, safely providing multiple iterations to carry out daily activities.

Through this tool and in collaboration with technologically skilled mixed reality developers, the software for the rehabilitation program to be applied to Parkinson's disease patients was also developed.

The main objective of this clinical study is to examine the effect of a mixed reality program compared to a traditional physiotherapy program on quality of life and motivation for the participation of people with Parkinson's disease.

Primary Outcome Measures: EuroQol 5 Dimension 5 Level, Measurement of quality of life. Likert scoring style (1-5) where higher scores represent worse state of quality of life, baseline, 4weeks follow up|The Short Form (12) Health Survey, Measurement of quality of life: The scores ranged from 0 to 100, where higher scores representing better quality of life, baseline, 4weeks follow up
Secondary Outcome Measures: Intrinsic Motivation Inventory, Measurement of intrinsic motivation: That contains 7 subcategories with average score from 1 to 7. Higher scores indicating better motivation, baseline, 4weeks follow up|Mini Balance Evaluation Systems Test, Measurement of functionality and Balance: The scale's scores ranging from 0 to 28, where higher scores represent better functionality, baseline, 4weeks follow up|Multidirectional Reach Test, Measurement of balance and functionality: Is the only scale that includes cm for the measurement of distance. Most healthy people present 25cm. People who present less than 18cm, indicates limitations on functional balance, baseline, 4weeks follow up|Nine-Hole Peg Test, Measurement of fine motor skills and functionality: The test scores are based on the average duration of four trials. Healthy females present 17.9-19.6 second and males 19-20.6 seconds. Higher average duration indicates limited fine mobility, baseline, 4weeks follow up