The Effect of Progressive Resistance Exercise Training (PRET) on CVRF in Adults With ID.
NCT Number: NCT06579898
Acronym: PRET
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Diabetes Mellitus, Type 2|Hypertension|Hypercholesterolemia|Obesity
Interventions: OTHER: Progressive resistance exercise training
Sponsor: Erasmus Medical Center
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 36
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2021-12-01
Completion Date: 2024-07-01
Locations: Amarant, Tilburg, Brabant, 5037LD, Netherlands|Abrona, Huis Ter Heide, Zuid-holland, 3712XA, Netherlands|Ipse de Bruggen, Zoetermeer, Zuid-holland, 2719EK, Netherlands

Summary:
Thanks to improved healthcare, the life expectancy of people with ID is increasing and is approaching that of the general population. Several studies have shown that most cardiovascular disease (CVRF) risk factors are as common or even more common in people with ID than in the general population. The guidelines of the American College of Sport Medicine (ACSM) state that a resistance training (RT) programme can can effectively reduce CVRF if performed at a high intensity. A secondary benefit of RT is the increase in muscle strength and muscle mass that can reduce and can improve the ability to perform activities of daily living (ADL), also two common problems in people with ID.

Primary Outcome Measures: Glycated Haemoglobin, mmol/mol, Outcome is measured with blood samples and analysed in a laboratory of ErasmusMC, through study completion, an average of 1 year|Systolic blood pressure, mm/Hg, Blood pressure is measured with a digital blood pressure device, through study completion, an average of 1 year|LDL cholesterol, mmol/L, Outcome is measured with blood samples and analysed in a laboratory of ErasmusMC, through study completion, an average of 1 year|Waist-hip ratio, cm, Waist-hip ratio is calculated after measuring waist circumference and hip circumference with a flexible tape measure., through study completion, an average of 1 year
Secondary Outcome Measures: Triglycerides, mmol/L, Outcome is measured with blood samples and analysed in a laboratory of ErasmusMC, through study completion, an average of 1 year|HDL cholesterol, mmol/L, Outcome is measured with blood samples and analysed in a laboratory of ErasmusMC, through study completion, an average of 1 year|Total cholesterol, mmol/L, Outcome is measured with blood samples and analysed in a laboratory of ErasmusMC, through study completion, an average of 1 year|Glucose, mmol/L, Outcome is measured with blood samples and analysed in a laboratory of ErasmusMC, through study completion, an average of 1 year|Muscle strength, kg, Muscle strength is measured with handgrip strength, 30 second chair stand and 5 times chair stand, through study completion, an average of 1 year|Muscle mass, kg, Muscle mass is measured with a bio electrical impedance device, through study completion, an average of 1 year|(I)ADL questionnaire, (I)ADL is measured with a questionnaire, which is filled in by proxy, through study completion, an average of 1 year|Fall incidents, Falls are reported during baseline and follow up with a calandar filled in by proxy, through study completion, an average of 1 year|ABC questionnaire, Behavioural issues is measured with the ABC questionnaire, which is filled in by proxy, through study completion, an average of 1 year