pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
ElectrocardioGraphic Imaging During Left bUndle Branch Implant to valiDate Ecg Criteria
NCT Number: NCT06509763
Acronym: GUIDE
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Cardiac Resynchronization Therapy
Interventions: DEVICE: ECGI system during LBBP implant
Sponsor: Hospital Clinic of Barcelona
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 50
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Start Date: 2022-09-29
Completion Date: 2024-12-15
Locations: Hospital Clinic de Barcelona, Barcelona, Spain

Summary:
The goal is to validate the resynchronization criteria with a non-invasive technique, during the LBBP implant. Non-invasive real-time ventricular activation maps will be created and analyzed before, during, and after the implantation of the left bundle branch lead, including right septal pacing, mid and deep septal pacing and pacing when reaching the left bundle branch according to the published standard LBBP criteria. Using these maps, the investigators will quantify activation times and evaluate changes in the ventricular sequence during implantation.

Primary Outcome Measures: Left ventricular resynchronization assessed by ECGI, Resynchronization assesed by non-invasive ECGI by the Left Ventricle Activation Time reduction and the septal activation ventricular pattern once reaching the LBBP according to the published ECG criteria., During procedure
Secondary Outcome Measures: VEU, Ventricular Electrical Uncoupling computed as the difference between the mean activation time of the left and the right ventricle, During procedure|LVDI, Left Ventricle Dyssinchrony Index computed as the standard deviation of individual activations recorded from the left ventricle., During procedure|Histogram Overlap, Overlapping of the right ventricle and left ventricle activation times histogram distributions as a parameter to assess the dyssinchrony between ventricles., During procedure|LVAT, Left Ventricular Activation Time computed as the difference between the earliest and the latest actvation of the left ventricle, During procedure|Isochronal Crowding, Number of Isochrones presented in the left ventricular activation map to assess the homogeneity of the activation, During procedure
The Postprandial Effects of a Carob-containing Meal
NCT Number: NCT06509750
Acronym: ACM
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Obesity
Interventions: OTHER: Carob-meal|OTHER: Non-carob-meal
Sponsor: Harokopio University
Sex: MALE
Age: ADULT
Enrollment: 20
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Start Date: 2024-07
Completion Date: 2025-05
Locations: Andriana Kaliora, Athens, 17671, Greece

Summary:
In an era where malnutrition and unhealthy eating patterns are salient contributors to global health deterioration, the urge for better access to nutritious alimentation is striking. Native to the Mediterranean region, the carob tree holds significant promise in this regard. With its rich nutritional profile, containing high levels of dietary fiber, polyphenols, and essential minerals, carob has been increasingly exploited by the food industry. Carob flour, derived from the pod after seed removal, is widely used as a cocoa substitute. The carob tree's fruit comprises 10% seeds and 90% pulp, containing numerous bioactive components such as dietary fiber, cyclitols, phenolic compounds, amino acids, and minerals. These components have been associated with beneficial effects on the gastrointestinal system and glucose absorption, with small-scale clinical studies indicating a hypolipidemic effect in patients with hypolipidemia. Nevertheless, comprehensive data from randomized controlled trials on the biological actions of carob remain restricted. This study explores the postprandial effects of incorporating carob into a Western-style meal, focusing on regulating glucose, insulin, and appetite hormones. The hypothesis is that a carob-enriched breakfast meal could positively influence satiety and appetite regulation, potentially offering a nutritious and sustainable dietary option for improving metabolic health. The high fiber and polyphenol content in carob are expected to modulate these postprandial responses, contributing to a better understanding of carob's role in dietary interventions. This study supports international initiatives to combat malnutrition and encourage a healthy diet, especially in light of the growing world population and the requirement for sustainable food supplies. By investigating the impact of carob on postprandial metabolic responses, this study seeks to contribute valuable insights into its potential benefits as part of a healthy diet.

Primary Outcome Measures: Plasma ghrelin levels, Plasma ghrelin levels in the two groups for the comparison of objective satiety between treatments., 3 hours|Changes in visual analogue scale, Changes in visual analogue scale for the comparison of subjective satiety between the two groups. Values range 0-10, the higher the value the higher satiety, 3 hours
Comparative Effects Of Mud Based Plyometric Jump Training on Volleyball Players
NCT Number: NCT06509711
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Sports Physical Therapy
Interventions: OTHER: PLYOMETRICS jump training with HIIT (4 weeks,3 sessions per week)|OTHER: PLYOMETRICS JUMP TRAINING WITHOUT HIIT (4weeks, 3sessions Per week)
Sponsor: Riphah International University
Sex: MALE
Age: CHILD, ADULT
Enrollment: 30
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Start Date: 2024-06-26
Completion Date: 2024-09-26
Locations: Pakistan sports board, Lahore, Punjab, Pakistan

Summary:
Volleyball is a high-intensity, anaerobic sport that alternates between brief rest intervals and explosive movements in both vertical and horizontal planes. Therefore, it is believed that essential components of successful athletic performance are explosive strength, speed and power which are defined as the neuro- muscular system of an individual's ability to manifests training the shortest amount of time. The complex movement of a vertical jump necessitates the coordination of multiple muscles in the arms, legs, and trunk. Being aware that a five-set volleyball match requires more than 250 jumps from each player. Eight weeks of plyometric jump training on mud and other unstable surfaces caused some changes in the biomechanical variables and physical fitness related to volley ball performance in volley ball players. Thus, by adding more high-intensity training, elite volleyball players can maximize their physical performance level during the competitive season.

Primary Outcome Measures: speed, speed of athlete measure by 50-m linear sprint, 0 week, 6 week, 12 week|calf girth, it is measured by Gulick tape, 0 week, 6 week, 12 week|power, it is measured by vertical jump, 0 week, 6 week, 12 week
Comparative Effects of Virtual Reality and Frenkel's Exercises in Patients With Stroke.
NCT Number: NCT06509698
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Stroke
Interventions: OTHER: virtual reality|OTHER: Frenkel's exercise
Sponsor: Riphah International University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 36
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-02-20
Completion Date: 2024-07-20
Locations: Alveena fatima, Lahore, Punjab, 54660, Pakistan

Summary:
To compare the effects of Virtual reality and Frenkel's exercises on balance, gait and quality of life in patients with stroke.

Primary Outcome Measures: berg balance scale, The BBS is an instrument that assesses functional balance performance in older adults using 14 tasks: sitting to standing, standing unsupported, sitting unsupported, standing to sitting, transfers, standing with eyes closed, standing with feet together, reaching forward with outstretched arm, retrieving object from floor, turning to look behind, turning 360 degrees, placing the foot alternately on a step, standing with 1 foot in front, and standing on 1 foot.18 The maximum score is 56 points, representing normal balance. Each item is scored from 0 (unable to perform) to 4 (normal performance), 6-weeks|time up and go, A straightforward performance test called the Timed-Up-and-Go (TUG) is frequently used to evaluate stroke patients' functional mobility and may be able to reveal some information on turning movement. The patient was really instructed to get up from a seated posture, walk three metres, turn around 180 degrees, walk three metres back, turn around 180 degrees, and then sit down once again. It is a viable tool to monitor walkable stroke patients because it is an easy-to-administer, quick test with good intra- and inter-rater reliability, strong convergent validity, and sensitivity to modest changes.4. The amount of time the patient needs to do the task in total determines their score. In fact, the TUG integrates several mobility functions, and its various subcomponents include intricate tasks., 6-weeks|stroke specific quality of life, A disease-specific patient-reported outcome measure called the SSQOL was created to evaluate the quality of life for stroke survivors. The 48 items are categorized into 12 domains: job, language, mobility, thinking, personality, mood, family roles, social roles, energy, self-care, vision, and upper extremity function. Each domain has three to six items. Likert scale answers are used for the items, with the least impacted item receiving a score of one and the unaffected item receiving a score of five. The questionnaire has a maximum total score of 245 and a minimum score of 49. A quality of life score of 60% of the maximum value indicates poor life., 6-weeks
Combined Effects of Plyometric and Endurance Training Among Female Hockey Players
NCT Number: NCT06509672
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Plyometric Exercise|Endurance Training|Hockey
Interventions: OTHER: Combined Plyometric and Endurance Training|OTHER: Plyometric Training|OTHER: Endurance training
Sponsor: Riphah International University
Sex: FEMALE
Age: ADULT
Enrollment: 30
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Start Date: 2024-06-14
Completion Date: 2024-09-14
Locations: Pakistan Sports Academy, Lahore, Pakistan

Summary:
Athletes need plyometric training as well as endurance training to enhance their speed, strength and agility in the field. Plyometric exercise involves stretching the muscle immediately before making a rapid concentric contraction. The combined action is commonly called a stretch-shortening cycle (SSC). Similar gains of maximal strength have been reported with traditional strength and plyometric training, but the latter approach appears to induce greater gains in muscle power. The combination of balance and muscle strength/power exercises seems to be an appropriate possibility, since both modalities induced adaptation on the neuromuscular level. A blocked combination of balance and muscle strength exercises effectively improve physical performance, and improvements in performance are more pronounced if balance exercises are followed by strength exercises than vice versa.

Primary Outcome Measures: Speed, will be measured by Sprint test, 0 week, 6 week, 12 week|Agility, will be measured by t test, 0 week, 6 week, 12 week|Strength, will be measured by 5 jump distance test, 0 week, 6 week, 12 week
Methacholine Challenge Test (MCT) in Healthy Adults
NCT Number: NCT06509659
Status: NOT_YET_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Hyperreactive Airway Disease
Interventions: DIAGNOSTIC_TEST: Methacholine Challenge Test
Sponsor: Allergi- og Lungeklinikken, Elsinore
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 25
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-08-10
Completion Date: 2024-12-23

Summary:
Knowledge of Methacholine Challenge Test (MCT) and impedance Oscillometry (IOS) is limited. Only three studies have included adult patients, and none of these with healthy controls. The three studies have combined IOS and spirometry in the same test, although it is not recommended to perform IOS after a test that requires deep breathing, e.g. FEV1 measurement. Deep breathing is considered to affect the impedance via reduced tone in the smooth muscle.

Primary Outcome Measures: Oscillometry; R5, Resistance at 5 Hz; kPa/L/s with FEV1 measurement, baseline (carried out with FEV1 measurement)|Oscillometry; R5, Resistance at 5 Hz; kPa/L/s change from baseline, Within 10 days from baseline and carried out without FEV1 measurement|Oscillometry; R20, Resistance at 20 Hz; kPa/l/s with FEV1 measurement, During intervention (carried out without FEV1 measurement)|Oscillometry; R20, Resistance at 20 Hz; kPa/L/s change from baseline, Within 10 days from baseline and carried out without FEV1 measurement|Oscillometry; X5, Reactance at 5 Hz; kPa/l/s with FEV1 measurement, During intervention (carried out without FEV1 measurement)|Oscillometry; X5, Reactance at 5 Hz; kPa/L/s change from baseline, Within 10 days from baseline and carried out without FEV1 measurement|Oscillometry; AX, Area of reactance; kPa/L with FEV1 measurement, During intervention (carried out without FEV1 measurement)|Oscillometry; AX, Area of reactance; kPa/L change from baseline, Within 10 days from baseline and carried out without FEV1 measurement|Oscillometry; Fres, Resonant frequency; Hz with FEV1 measurement, During intervention (carried out without FEV1 measurement)|Oscillometry; Fres, Resonant frequency; Hz change from baseline, Within 10 days from baseline and carried out without FEV1 measurement
Comparison of Tai Chi and Frenkel's Exercises in Patients With Stroke
NCT Number: NCT06509646
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Stroke
Interventions: OTHER: Tia Chi Exercise|OTHER: Frenkel's Exercise
Sponsor: Riphah International University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 36
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-02-01
Completion Date: 2024-07-20
Locations: Alveena fatima, Lahore, Punjab, 54660, Pakistan

Summary:
The main objective of this study is to compare the effectiveness of Tai Chi and Frenkel's exercises to improve balance, fall risk and activities of daily living in patients with stroke.

Primary Outcome Measures: The Barthel Index, The scoring is as follows: 0 = unable, 1 = needs assistance/help, 2 = independent. The for the ten items are summed and x 5 to get a total score out of 100. Proposed guidelines for interpreting Barthel scores are as follows: scores of 0-20 indicate "total" dependency., 12th week|The Berg Balance Scale (BBS), The Berg Balance Score (BBS) is the best-known balance measurement tool, originally designed to measure balance in older individuals. It consists of 14 items scored on an ordinal scale of 0 to 4 for a total of 56 points (a higher score indicates lower fall risk), 12th week|Fall Risk Assessment Tool (SRATIFY), The STRATIFY Scale is a tool used to identify risk factors for falls in hospitalized patients, using a 0-5 score to predict patients who will fall. It consists of five questions that assess the patient's history of falls, agitation, visual impairment, toileting needs, and mobility. The total score may be used to predict future falls, but it is more important to identify risk factors using the scale and then plan care to address those risk factors. The tool has good test-retest reliability and moderate inter-rater reliability, 12th week
Effects of Pain Neuroscience Education and Standard Rehabilitation Regime in Patients of Carpal Tunnel Syndrome
NCT Number: NCT06509633
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Wrist Injuries|Carpal Tunnel Syndrome
Interventions: OTHER: Pain Neuroscience education and standard rehabilitation regime|OTHER: standard Rehabilitation regime
Sponsor: Riphah International University
Sex: FEMALE
Age: ADULT
Enrollment: 30
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Start Date: 2024-02-01
Completion Date: 2024-11-10
Locations: Absaar medical center, Lahore, Punjab, 56300, Pakistan

Summary:
The aim of this study is to check the effects of Pain Neuroscience education and standard rehabilitation regime in patients of carpal tunnel syndrome.

Primary Outcome Measures: Numeric pain rate scale (NPRS), Patient level of pain will be assessed using this scale. This scale ranges from 0 to 10. 0 indicates "no pain" and 10 indicates "worst pain., 4th week
Secondary Outcome Measures: Pain Catastrophizing Scale (PCS), The Pain Catastrophizing Scale (PCS) was used to measure catastrophic thinking in response to pain through 13 statements with four possible options, from 1 "not at all" to 4 "all the time"., 4th week
Other Outcome Measures: Boston Carpal Tunnel Questionnaire (BCTQ), BCTQmeasures self reported functional status and severity of symptom. The BCTQ-SSS consists of 11 questions, each question provides 5 response choices, from 1 (no symptoms) to 5 (most severe/often)., 4th week|Goniometer, The range of motions like flexion extension radial deviation and ulnar deviation of wrist will be measured by Goniometer., 4th week
Physical and Cognitive Performance in Older Adults With Fatigue
NCT Number: NCT06509620
Status: NOT_YET_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Fatigue
Interventions: OTHER: Fatigue severity scale
Sponsor: Ain Shams University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 70
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-08-01
Completion Date: 2025-05-01
Locations: Ain Shams University, Cairo, 11566, Egypt

Summary:
Fatigue is a common symptom in older adults, often linked to various medical conditions, medications, and psychosocial factors, and it can adversely affect both physical and cognitive performance in the aging population, contributing to functional decline and reduced quality of life.

Assessment of the physical impact of fatigue on physical and cognitive performance in older adults can offer valuable insights for clinical practice and holistic geriatric care. Therefore, this study will validate subjective tools used for measuring the impact of fatigue against objective measures.

Primary Outcome Measures: The primary outcome measure the difference in cognitive performance between older adults with and without fatigue, assessed using the Montreal Cognitive Assessment (MoCA), compare the MoCA scores between the fatigued and non-fatigued groups using appropriate statistical methods (e.g., t-tests or ANCOVA adjusting for potential confounders). MOCA score is 30 with 18-25 = mild cognitive impairment, - 10-17= moderate cognitive impairment and - less than 10= severe cognitive impairment., 6 months|The primary outcome measure the difference in physical performance between older individuals with and without fatigue, assessed using 6 minutes walk test, The primary outcome will compare the 6 minutes walk test between the fatigued and non-fatigued groups using appropriate statistical methods (e.g., t-tests or ANCOVA adjusting for potential confounders)., 6 months
Scapular Stabilization Exercises Versus Eccentric Muscle Energy Techniques in Patients With Upper Crossed Syndrome
NCT Number: NCT06509594
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Upper Crossed Syndrome
Interventions: OTHER: Protocol of Scapular Stabilization Exercises;|OTHER: Protocol of Muscle Energy technique;
Sponsor: Riphah International University
Sex: ALL
Age: ADULT
Enrollment: 34
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Start Date: 2023-11-23
Completion Date: 2024-09
Locations: Faisal masaood teaching hospital Sargodha, Sargodha, Punjab, 40100, Pakistan

Summary:
This study will be a Randomized Clinical Trial in which Scapular Stabilization Exercises and Eccentric Muscle Energy technique will be applied on the individuals with upper crossed syndrome and changes will be recorded using different method and tools. Convenient sampling technique will be used to collect the data. The sample size of 34 patients will be recruited. Patients will be randomly allocated into two different groups through sealed envelope method. 17 patients will be allocated in each group. Group A will be treated with Scapular Stabilization Exercises along with hot pack; Group B will be treated with Eccentric Muscle Energy Technique along with hot pack. Craniovertebral Angle (CVA), Numeric Pain Rating Scale (NPRS), and Neck Disability Index (NDI) will be used as Data collecting tools.

Primary Outcome Measures: Numeric pain rating scale (NPRS), The NPRS was used to capture the patient's level of pain. Patients were asked to indicate the intensity of their current pain level using an 11-point scale, ranging from 0 (no pain) to 10 (worst pain imaginable)(8).

0 = no pain

1 to 4 indicate mild pain 5 or 6 indicate moderate pain 7 to 10 indicate severe pain NPRS exhibited moderate reliability (ICC = 0.67) in t, 4 weeks
Secondary Outcome Measures: Neck Disability Index (NDI), The NDI consists of ten items. Each item has six different assertions expressing progressive levels of pain or limitation in activities. Item scores range from 0 (no pain or limitation) to 5 (as much pain as possible or maximal limitation). The total NDI score ranges from 0 to 5 points., 4 weeks
Other Outcome Measures: Photogrammetry, A digital imaging technique will be used to evaluate head and neck posture in the standing position., 4 weeks
Vitamin E Supplementation for Children With Transfusion Dependent Beta Thalassemia on Different Iron Chelation Regimen
NCT Number: NCT06509581
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Beta-Thalassemia
Interventions: DIETARY_SUPPLEMENT: vitamin E|OTHER: PLACEBO
Sponsor: Ain Shams University
Sex: ALL
Age: CHILD, ADULT
Enrollment: 180
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2021-07-05
Completion Date: 2022-10-11
Locations: Ain Shams University, Cairo, Abbasia, 11517, Egypt

Summary:
repeated transfusions are the mainstay of disease management in most patients with transfusion dependent beta thalassemia.iron overload predispose to oxidative stress and tissue injury.

oxidative stress play important role in pathogenesis of anemia in beta thalassemia.

vitamin E is often depleted in thalassemia patients.

Primary Outcome Measures: effect of vitamin E on Liver iron concentration (LIC), measuring the LIC using MRI (magnetic resonance imaging) in mg/g, 12 months
Secondary Outcome Measures: effect of vitamin E on antioxidants enzymes, measuring antioxidants enzymes

* antioxidant enzymes,, 12 months|effect of vit E supplementation on SF, measuring serum ferritin(SF)in ng/ml, 12 months
Correlation Between Serum TK1 and Pathological Remission of Breast Cancer With Neoadjuvant Chemotherapy
NCT Number: NCT06509555
Status: RECRUITING
Study Type: OBSERVATIONAL
Conditions: Breast Neoplasms|TK1
Interventions: OTHER: non-intervention
Sponsor: Yunnan Cancer Hospital
Sex: FEMALE
Age: ADULT, OLDER_ADULT
Enrollment: 200
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-03-01
Completion Date: 2026-02-28
Locations: Yunnan Cancer Hospital, Kunming, Yunnan, China

Summary:
The levels and changes of sTK1 among different outcome groups in BCs with different molecular types were compared by stratification to explore whether sTK1 can be used as one of the tumor markers to predict pathological remission of NACT in BC patients.The changes of serum sTK1 level and ADC before surgery were continuously monitored, and combined with other clinicopathological factors, the pathological remission prediction model of NACT in BC patients was constructed and verified.

Primary Outcome Measures: Correlation analysis of serum TK1 and pathological remission of breast cancer with neoadjuvant chemotherapy, 2026.02
Measuring the Concurrent Validity of the Upper Limb Use Ratio With Accelerometers in an Ecological Situation After Stroke.
NCT Number: NCT06509542
Acronym: ValidFUR
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Cerebrovascular Accident
Interventions: BEHAVIORAL: Objective assessment of upper limb use during activities in ecological situation
Sponsor: University Hospital, Montpellier
Collaborators: Paul Coste Floret Hospital|Université Montpellier
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 25
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Start Date: 2024-09-01
Completion Date: 2026-04-01
Locations: CH Paul Coste Floret, Lamalou les Bains, 34240, France

Summary:
The purpose of this stufy is to measure the concurrent validity of the upper limb use ratio with accelerometers in an ecological situation after stroke.

Primary Outcome Measures: Concurrent validity (Intraclass Correlation Coefficient) of FuncUseRatio, using wrist-worn accelerometers, compared with the FuncUseRatio measured by video analysis., FuncUseRatio is the ratio of functional use of the paretic upper arm to the non-paretic upper arm measured by two methods (actimetry and video analysis),during the same occupational therapy sessions simulating activities of daily living with hemiparetic patients., Baseline
Secondary Outcome Measures: Number of functional movements performed with the upper limbs (FuncUse30), The functional movements are the movements with an amplitude greater than 30° within a spatial range of -30° to +30° around the horizontal, measured over a two-second time window (FuncUse30), Baseline|Ratio of the acceleration vector magnitude, The magnitude of the acceleration vector is the norm of the acceleration vector (SVM: Scalar Vector Magnitude) minus 1 for the gravitational force. The ratio between the paretic and non paretic arm is then calculated, Baseline|Activity count ratio, The activity count is the magnitude of the acceleration vector summed per second for each arm, and converted into an activity count (0.01664g/count). The ratio between the paretic and the non-paretic arm is then calculated., Baseline|Activity time ratio, The activity time is the sum of the seconds of arm activity for each arm. The ratio between the paretic and the non-paretic arm is then calculated., Baseline
The Effect of Motivational Interviewing Based on the COM-B Model
NCT Number: NCT06509529
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Cervical Cancer
Interventions: OTHER: Motivational Interviewing Based on the COM-B Model
Sponsor: T.C. ORDU ÜNİVERSİTESİ
Sex: FEMALE
Age: ADULT, OLDER_ADULT
Enrollment: 68
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Start Date: 2024-08-15
Completion Date: 2025-01-30

Summary:
This research will be conducted to determine the effect of motivational interviewing based on the COM-B model on women's cervical cancer health beliefs and participation in screening.

Primary Outcome Measures: "Cervical Cancer and Pap Smear Test Health Belief Model Scale", The scale was developed by Güvenç et al. (2011). Higher scores from the scale indicate increased sensitivity, caring and motivation; It indicates that benefits are perceived as high for benefit perception and obstacles are perceived as high for obstacle perception., 0th month and 1st month.|Status of Cervical Cancer Screening, This form was prepared by the researcher and will evaluate women's status of being screened for cervical cancer., 0th month and 1st month.
Effect of the Modified Sleeper-Stretch on the Elasticity of the Posterior and Posteroinferior Glenohumeral Capsule
NCT Number: NCT06509516
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Shoulder Pain|Shoulder Pain Chronic
Interventions: OTHER: Modified Sleeper-Stretch
Sponsor: University of Alcala
Sex: ALL
Age: ADULT
Enrollment: 64
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2024-09
Completion Date: 2025-11
Locations: Departamento de Enfermería y Fisioterapia, Alcalá De Henares, Madrid, 28805, Spain

Summary:
The goal of this quasi-experimental study is to determine the effect of the self-administered Modified Sleeper-Stretch on the elasticity of the posterior and posteroinferior glenohumeral capsule in adult individuals of both genders who either have clinical history of non-specific shoulder pain in a single shoulder or have no history of shoulder pain at all, being the assessment made by means of shear wave elastography. The main hypothesis it aims to confirm is:

• A soft tissue stretching program, using the Modified Sleeper-Stretch, aimed at general adult population with history of nonspecific shoulder pain that has occurred with glenohumeral internal rotation deficit improves the elasticity of the posterior and posteroinferior glenohumeral capsules, showing no significant effect on general adult population without history of shoulder pain.

Researchers will compare the effect of the Modified Sleeper-Stretch in the elasticity of the posterior and posteroinferior glenohumeral capsule in individuals with history of shoulder pain applying the technique on the affected shoulder and comparing with the healthy shoulder. In healthy individuals the intervention will be made on a randomly assigned shoulder and the effect will be compared to the non-interventional shoulder. Finally, a comparison between groups will be made considering only the intervention shoulder to see if there are differences in the effect amongst healthy and affected individuals.

Participants will be asked to follow a self-administered Modified Sleeper-Stretch program consisting of the execution of the stretch three times, for thirty seconds each time, with thirty seconds between stretches, daily, for twenty-eight days.

Primary Outcome Measures: Posterior glenohumeral capsule elasticity, Elasticity of posterior glenohumeral capsule as determined by quantitative shear-wave elastography, Day 1 (twice), day 28 (twice), day 56 (once)|Posteroinferior glenohumeral capsule elasticity, Elasticity of posteroinferior glenohumeral capsule as determined by quantitative shear-wave elastography, Day 1 (twice), day 28 (twice), day 56 (once)
Impact of Combined Oral Contraceptive Pills on Migraine
NCT Number: NCT06509503
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: PHASE4
Conditions: Migraine
Interventions: DRUG: Combined oral contraceptive|DRUG: Vaginal Ring
Sponsor: Kafrelsheikh University
Sex: FEMALE
Age: ADULT
Enrollment: 400
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2024-07-15
Completion Date: 2025-07-30
Locations: Kafr Elsheikh University Hospital, Kafr Ash Shaykh, 33511, Egypt

Summary:
The investigators will assess the effect of combined oral contraceptive pills (COCs) on migraine features and treatment response to allow better interpretation of the exact consequence of hormonal contraceptive use on migraineurs.

Primary Outcome Measures: The percentage of patients who achieved ≥ 50% change in the monthly migraine days frequency compared to the baseline frequency, We will assess The percentage of patients who achieved ≥ 50% change in the monthly headache days frequency compared to the baseline frequency in each group, 90 days
Secondary Outcome Measures: The severity of migraine attack on VAS score after three months of treatment, After three months of treatment, the investigators will assess the severity of migraine attacks on VAS scores.

VAS is a scale from one to ten where one is the least severe pain while ten is the most severest pain, 3 months|HIT-6 score change in each group after three months of treatment, The investigators assessed the absolute change in HIT6 score, the Headache Impact Test-6 (HIT-6) assessed the burden of headache in each group; the HIT-6 consists of six items: pain, social functioning, role functioning, vitality, cognitive functioning, and psychological distress, the patient answers each of the six related questions using one of the following five responses: "never", "rarely", "sometimes", "very often," or "always." These responses are summed to produce a total HIT-6 score that ranges from 36 to 78, where a higher score indicates a greater impact of headache on the daily life of the respondent. It has four impact grades: little-to-no impact (HIT-6 score: 36-49), moderate impact (HIT-6 score: 50-55), substantial impact (HIT-6 score: 56-59), and severe impact (HIT-6 score: 60-78), 3 months|The monthly migraine days per month, The investigators will assess the change in migraine days per month in each group, 3 months|The duration of migraine attack in hours after three months of treatment, After three months of treatment, the investigators will assess the duration of migraine attacks in hours in each group, 3 months|percentage of phenotypic features after three months of treatment, After three months of treatment, the investigators will assess percentage of phenotypic features in each group., 3 months
NKG2D CAR-T(KD-025) in the Treatment of Advanced NKG2DL+ Solid Tumors
NCT Number: NCT06509490
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Safety Issues
Interventions: DRUG: KD-025 cell injection
Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 9
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2024-07-17
Completion Date: 2026-03-26
Locations: Cancer hospital Chinese Academy of Medical Sciences, Beijing, Beijing, China

Summary:
This is a Phase 1, single-arm, single-center, open-label study to evaluate the safety and effectiveness of NKG2D-based CAR-T cells infusion in the treatment of advanced NKG2DL+ solid tumors.

Primary Outcome Measures: treatment-emergent adverse events(TEAEs), An adverse event is any undesirable experience associated with the use of a medical product in a patient, 3 months after single infusion|Dose-limiting toxicity (DLT) rate, A drug-related toxicity during treatment with the drug, the severity of which is clinically unacceptable, limiting the further escalation of drug dose., 3 months after single infusion|CAR positive T cells in patients, The time of CAR-T cell reach the peak and turn back to baseline, 6 months after single infusion
Secondary Outcome Measures: Objective response rate(ORR), objective tumor response rate will be calculated for patients with measurable disease per RECIST 1.1 only, 1month,2month,3month,6month,1 year after cell infusion]|Progression free survival(PFS), the time from the date of first infusion of the KD-025 to the first documented disease progression (according to RECIST 1.1) or death (due to any cause), whichever occurs first, 1month,2month,3month,6month,1 year after cell infusion]|Overall survival #OS#, the time from the date of first infusion of KD-025 to death of the subject, 1month,2month,3month,6month,1 year after cell infusion|Complete remission (CR), the time from the date of first infusion of KD-025 to death of the subject, 1month,2month,3month,6month,1 year after cell infusion
Effectiveness and Safety Comparison of Lunaphil Ultra (Hyaluronic Acid, by Espad Pharmed Co.) Versus Juvederm Ultra 4® (Hyaluronic Acid, by Allergan Co.) in Nasolabial Folds (NLFs) Management
NCT Number: NCT06509477
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Moderate or Severe Nasolabial Folds
Interventions: DEVICE: Hyaluronic acid Lunaphil Ultra (by Espad Pharmed Co.)|DEVICE: Hyaluronic acid Juvederm Ultra 4® (by Allergan Co.)
Sponsor: Espad Pharmed
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 104
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2021-12-01
Completion Date: 2023-11-11
Locations: Orchid Pharmed, Medical Department, Tehran, 19947-66411, Iran, Islamic Republic of

Summary:
Rationale and background: Skin aging is a complex process that results in various changes in the skin, including wrinkles, sun spots, and sagging skin. The NLF is a natural change that becomes more prominent with aging and significantly affects the beauty of the facial skin. Dermal fillers, particularly hyaluronic acid (HA) fillers, are commonly used to correct these signs of aging. This study aimed to compare the effectiveness and safety of Lunaphil Ultra with Juvederm Ultra 4® for treating NLFs.

Primary objective: Effectiveness assessment of Lunaphil Ultra Secondary objectives: Effectiveness and safety assessment of Lunaphil Ultra Study design: This is a randomized, double-masked, active controlled, within-subject, and equivalency clinical trial.

Setting: Subjects were treated with Lunaphil Ultra in one NLF and Juvederm Ultra 4® in the opposite NLF.

Primary Outcome Measures: Mean level of improvement from baseline in NLF severity score by Wrinkle Severity Rating Scale (WSRS), The scores are from 1 to 5, 1 indicating no visible folds and 5 indicating extreme folds, 24 weeks
Secondary Outcome Measures: Number of subjects with an improved score from baseline based on Physician Global Aesthetic Improvement Scale (PGAIS), The scores are from 1 to 5, 1 indicating exceptional improvement and 5 indicating worsened results, 24 weeks|Proportion of NLFs maintaining a clinically significant improvement in NLF severity score by Wrinkle Severity Rating Scale (WSRS), ≥1-point reduction from baseline. The scores are from 1 to 5, 1 indicating no visible folds and 5 indicating extreme folds, 24 weeks|The injected volume to obtain optimal aesthetic result, initial treatment + touch-up, 2 weeks|The number of NLFs receiving touch-up treatment, Counting the number of subject who need additional injection, 2 weeks|Evaluation of adverse events during 24 weeks, All reported AEs are classified based on the Medical Dictionary for Regulatory Activities (MedDRA) terms and are graded according to the Common Terminology Criteria for Adverse Events (CTCAE) v5.0., 24 weeks
RESPONSE OF METABOLIC SYNDROME SEVERITY SCORE TO HIGH INTENISTY INTERVAL TRAINING IN WOMEN WITH CENTRAL OBESITY
NCT Number: NCT06509464
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Metabolic Syndrom
Interventions: DEVICE: High intensity interval training|DIETARY_SUPPLEMENT: Caloric restricted diet
Sponsor: Soma Adel Gaber Abd El-Ghany
Sex: FEMALE
Age: ADULT
Enrollment: 48
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Start Date: 2024-07-20
Completion Date: 2024-09-15
Locations: Faculty of physical therapy cairo university, Giza, 12611, Egypt

Summary:
This study will be conducted to investigate any significant effect of high intensity interval training on metabolic syndrome severity score in women with central obesity.

Primary Outcome Measures: Metabolic syndrome severity score, 6weeks|Physical efficiency index using Modified Harvard Step test, 6weeks|The 45-item Diet Satisfaction Questionnaire (DSat-45, 6 weeks
Retention Rate of Giomer Pit and Fissure Sealant Applied With or Without Etching
NCT Number: NCT06509451
Status: ACTIVE_NOT_RECRUITING
Study Type: INTERVENTIONAL
Phases: PHASE4
Conditions: Caries Prevention
Interventions: DRUG: Giomer pit and fissure sealant without etching|DRUG: Giomer pit and fissure sealant with etching
Sponsor: Cairo University
Sex: ALL
Age: CHILD, ADULT
Enrollment: 52
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Start Date: 2023-05-01
Completion Date: 2024-08-01
Locations: Faculty of dentistry, cairo university, Cairo, 11555, Egypt

Summary:
The aim of this study is to evaluate the retention rate of Giomer S-PRG filler containing pit and fissure sealant applied with or without etching by using split mouth technique.with null hypothesis that Giomer S-PRG filler containing pit and fissure sealant applied either with or without etching will have the same retention rate.

Primary Outcome Measures: retention rate, To assess the sealant retention rate either total retention, partial loss or total loss, 3 months, 6months , 1 year
Effectiveness and Safety Evaluation of Embella (Deoxycholic Acid, by Espad Pharmed Co.) in Management of Submental Fat
NCT Number: NCT06509438
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Submental Fullness
Interventions: DEVICE: Embella (Deoxycholic acid, produced by Espad Pharmed Co.)
Sponsor: Espad Pharmed
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 20
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2023-04-10
Completion Date: 2024-01-01
Locations: Center for Research and Training in Skin Diseases and Leprosy, Tehran, 1416613675, Iran, Islamic Republic of

Summary:
Submental fat (SMF) is a factor affecting beauty that makes people feel uncomfortable about themselves. In 2015, deoxycholic acid with the brand name KYBELLA® was approved by the American FDA for treatment of submental fat. The purpose of this study is to evaluate the safety and effectiveness of deoxycholic acid injection with the brand name Embella®, manufactured by Espad Pharmed Company, for treatment of this condition.

Research Objectives

Primary objective:

Effectiveness and safety of Embella® in reducing submental fat

Secondary objective:

Effectiveness assessment of Embella® in improving SMF grading Effectiveness assessment of Embella® in reducing submental fat diameter

Primary Outcome Measures: A minimum of one grade improvement in the standard submental fat (SMF) assessment grading, The scales are from 0 to 4, 0 indicating no localized submental fat and 4 indicating extreme submental convexity, weeks 4 and 12 after the last injection
Secondary Outcome Measures: Measurement of submental fat thickness, Using calipers, Weeks 4 and 12 after the last injection|Pain intensity was assessed using the VAS from 0 to 10, Visual Analogue Scale (VAS): pain intensity scale where 0 indicates no pain and 10 indicates the maximum pain imaginable, day 1, week 4 and 8|Subject satisfaction was assessed using the VAS from 0 to 10,, Visual Analogue Scale (VAS): satisfaction factor scale where 0 indicates complete dissatisfaction and 10 indicates maximum satisfaction, week 4 and 12 after the last injection|Assessment of all adverse events immediately after the injections and during the study period., Safety assessment including the incidence of all reported AEs and severity graded as follows: mild = 1, moderate = 2, and severe = 3, Immediately after all of the injections and at weeks 4 and 12 after the last injection
Pelvic Congestion Syndrome Post Tubal Ligation Versus Salpingectomy Performed During Caesarean Section
NCT Number: NCT06509425
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Pelvic Congestion Syndrome
Interventions: PROCEDURE: salpingectomy during caesarean section|PROCEDURE: tubal ligation during caesarean section
Sponsor: Ain Shams University
Sex: FEMALE
Age: ADULT, OLDER_ADULT
Enrollment: 64
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Start Date: 2024-05-21
Completion Date: 2024-09
Locations: Ain Shams Maternity Hospitals, Cairo, Abaseya, 11588, Egypt

Summary:
Permanent tubal sterilization during Caesarean section is a reliable method of contraception. It is done either by bilateral tubal ligation or bilateral salpingectomy according to surgeon's preference.

Studies revealing bilateral salpingectomy has an added benefit of primary prevention of ovarian cancer has encouraged surgeons to perform bilateral salpingectomy rather than tubal ligation as a risk reducing surgery owing to the acceptance of fallopian tubes as the origin of high grade serous ovarian cancer.

Another aspect to take into consideration is the post tubal ligation syndrome as it severely affects the quality of life. Diagnosis is based on clinical picture, imaging, and exclusion of other causes of chronic pelvic pain. Women experience dysmenorrhea, dyspareunia, menstrual irregularities, and pelvic pain. The gold standard is venography; however, the first choice for initial evaluation is duplex ultrasound.

In this study, we assess impact of bilateral salpingectomy versus tubal ligation in terms of pelvic congestion by participant's symptoms and ultrasound findings

Primary Outcome Measures: symptoms of pelvic congestion syndrome, A questionnaire to detect changes in menstrual pattern or new onset of pelvic pain., Ten weeks postoperative
Secondary Outcome Measures: signs of pelvic congestion syndrome, Transvaginal US will be done 10 weeks postoperative for detection of signs of pelvic congestion, Ten weeks postoperative|intraoperative complications, blood transfusion, visceral injury and increased operative time, intraoperative
Care Package for Preventing Pressure Ulcers in ICU Patients
NCT Number: NCT06509399
Status: COMPLETED
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Pressure Ulcer|Nursing Caries
Interventions: OTHER: care package
Sponsor: Abant Izzet Baysal University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 72
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Start Date: 2023-05-15
Completion Date: 2023-09-15
Locations: Abant Izzet Baysal University Faculty of Health Science, Bolu, Merkez, 14100, Turkey|Bolu Abant İzzet Baysal Üniversitesi/Sağlık Bilimleri Fakültesi, Bolu, 14100, Turkey

Summary:
The aim of this study is to evaluate the effectiveness of the care package (CP) developed to prevent pressure injury (PI) in patients in intensive care and to evaluate the effect of the training given to nurses on their knowledge levels and attitudes.

Primary Outcome Measures: Pressure Ulcer Formation, Ulcer formation was monitored. Patients were followed up for at least 10 days in this respect., through study completion, an average of 1 year
Secondary Outcome Measures: Knowledge levels of nurses, Knowledge levels of nurses were tested before and after the training with the pressure sore assessment form prepared by the researchers., through study completion, an average of 1 year