Multidimensional Recovery Patterns and Prognostic Factors After Stroke
NCT Number: NCT06553755
Status: ACTIVE_NOT_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Stroke
Sponsor: Taipei Medical University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 1270
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-08-12
Completion Date: 2026-07-31
Locations: Taipei Medical University, Taipei, Taiwan

Summary:
This study aims to compare the 1-year recovery trajectories of multidimensional functional recovery among stroke survivors after discharge from acute care.

To address this purpose, a retrospective analysis will be conducted using clinical data from two independent cohorts derived from previously published prospective observational studies. The study will conduct generalized estimating equations and mixed-effects regression models to assess differences in recovery trends among stroke subgroups.

The findings will provide detailed profiles of longitudinal changes in functional outcomes one year after discharge from acute care. These results will clarify how stroke subtypes influence long-term functional outcomes and will guide the development of targeted interventions.

Primary Outcome Measures: Participation Measure-3 Domains, 4 Dimensions (PM-3D4D), The PM-3D4D is a 24-item measure that was designed to evaluate three domains of participation: Productivity, Social, and Community. Respondents are asked to rate each item on four dimensions: (1) 'Diversity of participation' (yes \[1\] vs. no \[0\]); (2) 'Frequency'(5- and 7-point scales, from "never" to "everyday or almost everyday"); (3) 'Desire for change' (yes \[1\] vs. no\[0\]); and (4) 'Perceived difficulty' (4-point scale, from "very difficult" \[1\] to "not difficult at all" \[4\]). Each dimensional score of the PM-3D4D can be separately summed for each domain. Psychometric properties of the PM-3D4D were established in rehabilitation populations., From discharged from acute care up to 1 year|Activity Measure for Post-Acute Care (AM-PAC), The Activity Measure for Post-Acute Care (AMPAC) Outpatient Short Forms consists of three subscales that assesses three activity domains: basic mobility (18 items), daily activity (15 items), and applied cognitive (19 items). Each item asks the respondent to rate the difficulty to perform specified activities using a 4-point scale. The summary scores range 18-72, 15-60, 19-76 points respectively among three subscales. Higher score indicates better function of the specific domain. The summary scores for each subscale will be transformed into standardized scores on the t-score scale., From discharged from acute care up to 1 year|Euro-QoL-5-Dimension-3 Level (EQ-5D-3L), The Euro-QoL-5-Dimension-3 Level (EQ-5D-3L) is used to assess participant's health related quality of life which consist of 5 ordinal scale items and 1 item with visual analog scale. Ordinal scales are rated 0-3 points with higher score indicating the pooer health-related quality of life. visual analog scale are rated by respondents reporting perceived health status with a grade ranging from 0 to 100 with higher score indicating the better health status)., From discharged from acute care up to 1 year|Montreal Cognitive Assessment (MoCA), Montreal Cognitive Assessment (MoCA) is a clinician-reported measure consisting of cognition domains such as: visuospatial skills, executive functions, attention, concentration, calculation, language, abstraction, memory, and orientation. The summary score ranges from 0-30 points with higher scores indicating better cognitive function., From discharged from acute care up to 1 year
Secondary Outcome Measures: Barthel Index (BI), Barthel Index (BI) is a commonly used measurement indicating independence level of self-care., From discharged from acute care up to 1 year|Modified Rankin Scale (mRS), The modified Rankin Scale (mRS) is designed to measure functional status after a stroke. Each participant is rated 0-6 point on an ordinal scale with lower score indicating greater functional status after stroke., From discharged from acute care up to 1 year|The Center for Epidemiologic Studies Depression Scale (CES-D), The Center for Epidemiologic Studies Depression Scale (CES-D) is a self-reported outcome measure of depressive symptoms, From discharged from acute care up to 1 year
Other Outcome Measures: National Institutes of Health Stroke scale (NIHSS), National Institutes of Health Stroke scale (NIHSS) is a 15-item measurement designed to assess neurological symptoms, From discharged from acute care up to 1 year|Personal factors, General information relating to stroke individuals, including age of onset, sex, diagnosis, time since onset, comobidities, education, marital status, monthly income, etc., From discharged from acute care up to 1 year|Environmental factors, Information relating to the environments in which the stroke individuals live, including living with caregiver(s), house with/without a elevator, etc., From discharged from acute care up to 1 year