Effect of Acupoint Stimulation on Lactate During Cerebral Endovascular Intervention
NCT Number: NCT06521645
Acronym: ASLA
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Endovascular Procedures
Interventions: OTHER: transcutaneous electrical stimulation|OTHER: electrodes attachment
Sponsor: Air Force Military Medical University, China
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 28
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-07-30
Completion Date: 2025-07-30
Locations: the First Affiliated Hospital of the Air Force Military Medical University, Xi'an, Shaanxi, China

Summary:
It is advocated that neuroprotection should be increased before endovascular treatment and that the penumbra should be protected from reperfusion damage after recanalization. Monitoring lactate and pH levels in acute ischemic stroke patients who have had endovascular recanalization can be utilized to predict mortality and morbidity, especially in the first five hours after the procedure. This study aims to observe the effect of acupoint stimulation on lactate level during endovascular recanalization.

Primary Outcome Measures: arterial level of lactate at 30 minutes after recanalization, 30 minutes after recanalization
Secondary Outcome Measures: arterial level of lactate immediately after recanalization, about 1 minute after recanalization|arterial level of lactate at 8 hours after recanalization, 8 hours after recanalization|pH value at 8 hours after recanalization, 8 hours after recanalization|Concentration of HCO3- at 8 hours after recanalization, 8 hours after recanalization|Concentration of base excess at 8 hours after recanalization, 8 hours after recanalization|Partial pressure of oxygen at 8 hours after recanalization, 8 hours after recanalization|Partial pressure of carbon dioxide at 8 hours after recanalization, 8 hours after recanalization|pH value at 30 minutes after recanalization, 30 minutes after recanalization|Concentration of HCO3- at 30 minutes after recanalization, 30 minutes after recanalization|Concentration of base excess at 30 minutes after recanalization, 30 minutes after recanalization|partial pressure of oxygen at 30 minutes after recanalization, 30 minutes after recanalization|partial pressure of carbon dioxide at 30 minutes after recanalization, 30 minutes after recanalization|pH value immediately after recanalization, about 1 minute after recanalization|Concentration of HCO3- immediately after recanalization, about 1 minute after recanalization|Concentration of base excess immediately after recanalization, about 1 minute after recanalization|partial pressure of oxygen immediately after recanalization, about 1 minute after recanalization|partial pressure of carbon dioxide immediately after recanalization, about 1 minute after recanalization|Concentration of serum interleukin-6 at 30 minutes after recanalization, 30 minutes after recanalization|Concentration of serum tumor necrosis factor α at 30 minutes after recanalization, 30 minutes after recanalization|Concentration of serum brain-derived neurotrophic factor at 30 minutes after recanalization, 30 minutes after recanalization|score of modified Rankin's scale at 24 hours after recanalization, the minimum and maximum values of modified Rankin's scale is 0 and 5, and higher scores mean a worse outcome., 24 hours after recanalization|incidence of stroke during hospitalization, From end of surgery to discharge from hospital, at an average of 5 days|Incidence of death during hospitalization, From end of surgery to discharge from hospital, at an average of 5 days|length of hospitalization, From end of surgery to discharge from hospital, at an average of 5 days