Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation
NCT Number: NCT06457373
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: Demineralized Dentin Allograft|PROCEDURE: Demineralized Dentin Autograft
Sponsor: Horus University
Sex: ALL
Age: ADULT
Enrollment: 40
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-09-01
Completion Date: 2025-09-01
Locations: Faculty of Dentistry- Horus University in Egypt, Damietta, New-Damietta, 34518, Egypt

Summary:
This study is designed to evaluate and compare clinically and radiographically the effectiveness of Demineralized Dentin Allograft (DDA) versus Demineralized Dentin Autograft (Auto-DD) for preservation of alveolar ridge dimensions after surgical extraction of the impacted mandibular third molar.

Primary Outcome Measures: Measuring and comparing the height of bone between the two groups, We will measure the height of the alveolar ridge clinically by using ridge mapping caliper (special caliper forceps used for measuring ridge dimensions) and radiographically on the cone-beam computed tomography (CBCT) and comparing the results of the study group (20 sockets) with the control group (the other 20sockets), to assess the effectiveness of Demineralized Dentin Allograft for ridge preservation, Immediately post-operative, 3months post-operative, 6months post-operative|Measuring and comparing the width of bone between the two groups, We will measure the width of the alveolar ridge clinically by using ridge mapping caliper (special caliper forceps used for measuring ridge dimensions) and radiographically on the cone-beam computed tomography (CBCT) and comparing the results of the study group (20 sockets) with the control group (the other 20sockets), to assess the effectiveness of Demineralized Dentin Allograft for ridge preservation, Immediately post-operative, 3months post-operative, 6months post-operative
Secondary Outcome Measures: Assess and comparing the mouth opening of both groups, Assess the mouth opening of the patient using a millimeter ruler (by measuring the distance between maxillary incisal edge and mandibular incisal edge) and comparing the results of both groups, One day post-operative, one week post-operative|Assess and comparing the swelling of both groups, Swelling levels after surgery will be measured using anatomic landmarks (Tragus-Labial commissure and Tragus-Pogonion), the distances between the landmarks used for the evaluation methods will be measured before the operation.

All measurements will be done using millimeter ruler, while the patient will be seated., One day post-operative, one week post-operative|Assess and comparing the pain of both groups, we will use the Visual Analogue Scale (VAS) for pain measurement, One day post-operative, one week post-operative|Assess and comparing the soft tissue parameters (bleeding on probing and color of the gingiva) of both groups, The bleeding on probing will be assessed by using periodontal probe and this will be done around mandibular first and second molars, One day post-operative, one week post-operative