Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults
NCT Number: NCT06507189
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Sarcopenia
Interventions: OTHER: Combined endurance and resistance training
Sponsor: Florida Institute for Human and Machine Cognition
Collaborators: Oklahoma Medical Research Foundation|University of Florida
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 250
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Start Date: 2024-09-01
Completion Date: 2029-07-01
Locations: Florida Institute for Human and Machine Cognition, Pensacola, Florida, 32502, United States|Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104, United States

Summary:
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.

Primary Outcome Measures: Cardiorespiratory fitness (CRF), A primary outcome of this investigation is cardiorespiratory fitness (CRF). The CRF is the amount of oxygen (ml/kg) that is used during exercise and how efficient you are using that oxygen. The exercise used to measure oxygen uptake is a stationary bicycle with increasing intensity until you are able to maintain pace. Your expired air is collected with a mask or mouthpiece and analyzed with an oxygen and carbon dioxide sensor., 23 weeks|Functional muscle quality (fMQ), A primary outcome of this investigation is functional muscle quality (fMQ). This is a ratio of knee extension strength to thigh leanness. Knee extension strength is the maximum amount of weight you can successfully lift one time. Thigh lean mass is measured with the dual energy x-ray absorptiometry (DEXA). This is a common tool used to measure bone density, but it is very efficient at determining fat and lean masses partitioned in the body., 23 weeks
Secondary Outcome Measures: Balance, Balance will be assessed with tools such at the short physical performance battery (SPPB). The SPPB is a clinical test used to measure balance in three areas of balance: stand-in balance, gait speed and chair stand time. The overall higher score you have is an indicator of better balance., 23 weeks|Cognitive performance, An assessment such as the Trail Making Task (TMT)is used to measure reaction times at the beginning of and after the exercise intervention., 23 weeks|Body composition, Body composition will be measured four times pre and post to exercise intervention., 23 weeks|Metabolic health, A clinical assessment such as continuous glucose monitoring (CGM) will be use to measure metabolic health at the beginning, the middle, and end of intervention time points. CGM will monitored for seven days pre and post to the exercise intervention. This can be used to determine blood glucose response before and after exercise., 23 weeks|Metabolic health, The HOMA-IR will is test used to determine protein turn over or how efficient you are at processing proteins., 23 weeks