Light vs. Moderate Intensity Exercise in Individuals With Myasthenia Gravis
NCT Number: NCT06491238
Acronym: MG-Ex
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Myasthenia Gravis
Interventions: BEHAVIORAL: Light Intensity Exercise|BEHAVIORAL: Moderate Intensity Exercise
Sponsor: HealthPartners Institute
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 20
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2024-08
Completion Date: 2025-07
Locations: HealthPartners Neuroscience Center, Saint Paul, Minnesota, 55130, United States

Summary:
The purpose of this pilot study is to examine the effect of light vs. moderate intensity exercise on health outcomes. Participants will be enrolled into the NeuroWell exercise program, which is geared toward individuals with neurological disorders or injuries and led by Certified Exercise Physiologists (CEPs) at the HealthPartners Neuroscience Center. A total of 20 people with MG will be enrolled in this study and participate in a small group exercise program 3 times a week for 12 weeks. Participants will be randomized into two exercise groups: 1) Light intensity or 2) Moderate intensity. We hypothesize that individuals in the light intensity exercise group will be able to achieve the same improvement in outcomes as the moderate intensity group.

Primary Outcome Measures: Cardiovascular Test - 6-minute walk test, Pre-post change in distance a person can walk during the 6-minute walk test. Change = Post distance - pre distance. Larger positive difference in distance indicates a larger improvement in cardiovascular health from pre-post program., 12 weeks|Strength Test - 1-RM Upper Limb, Pre-post change in weight that can be lifted during the 1-RM test. Change = Post 1-RM upper limb weight -pre 1-RM upper limb weight. Larger positive difference in weight lifted indicates a larger improvement in upper limb strength from pre-post program., 12 weeks|Strength Test - 1-RM Lower Limb, Pre-post change in weight that can be lifted during the 1-RM test. Change = Post 1-RM lower limb weight -pre 1-RM lower limb weight. Larger positive difference in weight lifted indicates a larger improvement in lower limb strength from pre-post program., 12 weeks|Functional strength - Sit to stand test, Pre-post change in time it takes a person to transfer from seated to standing position and then back to seated position 5 times. Change = Post time to complete sit to stand test - pre time to complete sit to stand test. Larger positive difference in time to complete sit to stand test indicates increase in functional strength from pre-post program., 12 weeks
Secondary Outcome Measures: MG-Quality of life (QOL), Change in MG-QOL 15 scale. Post score - pre score. Range \[-30 to 30\]. Negative change (drop in score from pre to post) indicates improvement in quality of life., 12 weeks|MG-Activities of Daily Living (ADL), Change in MG-ADL scale. Post score - pre score. Range \[-24 to 24\]. Negative change (drop in score from pre to post) indicates improvement in ability to perform activities of daily living., 12 weeks|Fatigue - Fatigue Severity Scale, Change in fatigue severity scale (FSS). Post score - pre score. Range \[-63 to 63\]. Negative change (drop in score from pre to post) indicates improvement in fatigue related to MG., 12 weeks