Effects of Resistance Training Intensity on Cardiovascular Parameters of Hypertensive Women
NCT Number: NCT06538454
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Arterial Hypertension|Postmenopausal; Menorrhagia|Cardiovascular Diseases
Interventions: BEHAVIORAL: Resistance training
Sponsor: University of Sao Paulo
Sex: FEMALE
Age: ADULT, OLDER_ADULT
Enrollment: 24
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Start Date: 2024-07-23
Completion Date: 2025-09
Locations: Laboratório de Fisiologia do Exercício e Metabolismo, Ribeirão Preto, SP, Brazil

Summary:
The goal of this clinical trial is to understand about the effects of resistance training (RT) intensity on cardiovascular parameters in postmenopausal women with systemic arterial hypertension (SAH). The main research questions are:

* Does the intensity of RT impact blood pressure (BP) in postmenopausal women with SAH?
* How does RT intensity affect heart rate (HR) and their variability (HRV), endothelial function (EF), and nitric oxide (NO) biomarker synthesis in this population?
* What are the effects of RT intensity on affectivity and rate of perceived exertion (RPE)?

Researchers will compare two different intensities of RT (60% of the load for 1 repetition maximum \[1RM\] and 80% of 1RM) to determine their effects on the mentioned cardiovascular and perceptual parameters.

Participants will:

In the acute experiment:

* Perform the same RT session in a crossover design, training with 60% of 1RM in one condition and 80% of 1RM in another condition
* Have BP, HR, and HRV measured before, immediately after, and for one hour post-session
* Report affectivity before each session and at the end, along with RPE

In the chronic experiment:

* Be randomized into two groups: one training with 60% of 1RM and the other with 80% of 1RM
* Undergo a 10-week intervention period with evaluations before, during, and after the intervention
* Have BP, HR, affective responses, and RPE measured at multiple time points
* Have EF, HRV, and salivary concentrations of NO biomarkers assessed before and after the intervention

Primary Outcome Measures: Values of systolic and diastolic blood pressure (mmHg), This measurement will be assessed in both stages.

In the acute phase, this measurement will be performed on the participant before, after and up to one hour after the end of the training session.

In the chronic phase, this measure will be performed in participant after a rest in a quiet room with temperature controlled before (baseline) and after 10 week of intervention. Futhermore, along the intervention these measure will be performed before and after training sessions., Up to end of study data collection (both stages), i.e, assesed up to 1 year
Secondary Outcome Measures: Values of heart rate variability (ms), This measurement will be assessed in both stages.

In the acute phase, this measurement will be performed on the participant before, after and up to one hour after the end of the training session.

In the chronic phase, this measure will be performed in participant after a rest in a quiet room with temperature controlled before (baseline) and after 10 week of intervention. Futhermore, along the intervention these measure will be performed before and after training sessions., Up to end of study data collection (both stages), i.e, assesed up to 1 year|Endothelial function (Flow mediated dilatation %), This measurement will be performed before acute experiment (baseline) and after 10 week intervention (end of chronic experiment) in a quiet room with controlled temperature., Up to end of chronic experiment (baseline and post-intervention values), assesed up to 1 year|Salivary concentrations of nitric oxide (mmol/L), This measurement will be performed before acute experiment (baseline) and after 10 week intervention (end of chronic experiment)., Up to end of chronic experiment (baseline and post-intervention values), i.e, assesed up to 1 year|Rate of perceived exertion (scale from 1 to 10), This measurement will be performed after all training sessions, i.e, in both stages. The participants will be remembered the meanings of the scale., Up to end of study data collection (both stages), i.e, assesed up to 1 year|Affectivity (scale from -5 to +5), This measurement will be performed before and after all training sessions, i.e, in both stages. The participants will be remembered the meanings of the scale., Up to end of study data collection (both stages), i.e, assesed up to 1 year