Changes in Attentional Control After a Focal Seizure.
NCT Number: NCT06466681
Acronym: ATTENTIONEPIF
Status: RECRUITING
Study Type: OBSERVATIONAL
Conditions: Temporal Lobe Epilepsy|Frontal Lobe Epilepsy|Others Subtypes
Interventions: OTHER: All included subjects
Sponsor: University Hospital, Lille
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 100
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-03-04
Completion Date: 2027-03-09
Locations: University Hospital,, Lille, 59000, France

Summary:
Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.

Primary Outcome Measures: Subtest of divided attention of the Test of Attentional Performance (TAP), A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure., 24 hours
Secondary Outcome Measures: N200 amplitude and latency, A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure., 24 hours|Strength of EEG functionnal connectivity during an attentional task (global and regional), A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure., 24 hours|Variation of power in several frequency bands (theta, alpha and beta) during an attentional task., A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure., 24 hours|Magnetic resonance imaging functional connectivity., up to 5 days|Differences in N200 and P300 amplitude and latency recorded between different subgroups according to the epileptic focus., A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure., 24 hours|P300 amplitude and latency, A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure., 24 hours|Differences in strength of EEG functional connectivity during an attentional task recorded between different subgroups according to the epileptic focus., 24 hours|Differences in variation of power in several frequency bands (theta, alpha and beta) during an attentional task recorded between different subgroups according to the epileptic focus., 24 hours|Differences in magnetic resonance imaging functional connectivity recorded between different subgroups according to the epileptic focus., 24 hours