One Year Mortality and Morbidity With Hyperglycemia Among Acute Cerebrovascular Accident Patients in Emergency Department: A Cohort Study
NCT Number: NCT06560983
Status: RECRUITING
Study Type: OBSERVATIONAL
Conditions: Cardiovascular Diseases
Interventions: OTHER: The investigators are planning to do a observational cohort study, hence won't be doing any intervention.
Sponsor: Institute of medicine, Maharagjung medical campus
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 46
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-01-15
Completion Date: 2027-12-15
Locations: Bibek Rajbhandari, Kathmandu, Bagmati, 44600, Nepal|Bibek Rajbhandari, Kathmandu, Bagmati, 44600, Nepal

Summary:
The "One Year Mortality and Morbidity Outcome with Hyperglycemia among Acute Cerebrovascular Accident Patients in Emergency Department" is an extensive prospective cohort study designed to look into how hyperglycemia affects the short- and long-term outcomes of patients who present to the emergency room with acute cerebrovascular accidents (CVAs). Worldwide, cerebrovascular accidents are a major source of both death and morbidity. Research on the long-term consequences of hyperglycemia and its association with worse outcomes during the acute period of stroke is still underway. This study aims to close this information gap by investigating the relationship between the rates of immediate short- and one-year mortality rates and morbidity and hyperglycemia at the time of CVA presentation. The research design adopts a prospective cohort approach, aligning with established guidelines to ensure methodological rigor. Systematic random sampling will be employed, with a calculated sample size of 60. Patients with acute cerebrovascular accidents who are admitted to the emergency department will be a carefully chosen group for the research. The investigators will carefully gather important data, such as baseline clinical parameters, medical history, demographics, and blood glucose levels upon admission. Throughout a year, follow-up evaluations will be carried out regularly to monitor death rates and evaluate functional and neurological results in research participants using the modified Rankin score. The study will use a structured questionnaire for data collection, involving chart review and face-to-face interviews at specified intervals. Data analysis will include bivariate analysis, logistic regression, and Kaplan-Meier analysis to identify predictors of mortality and morbidity. The ultimate goal of this research is to improve patient care, prognosis, and long-term quality of life for those impacted by this critical medical condition by illuminating the prolonged effects of hyperglycemia in acute cerebrovascular accident patients and deepening our understanding of the intricate interactions between metabolic factors and stroke outcomes.

Primary Outcome Measures: Mortality outcomes among hyperglycemic patients with acute stroke in the Emergency Department., Outcome Measure: Mortality rate among hyperglycemic patients with acute stroke. Unit of Measure: Percentage (%) or absolute number of deaths., 1, 3, and 12 months|Morbidity outcomes among hyperglycemic patients with acute stroke in the Emergency Department., Outcome Measure: Morbidity as assessed by the Modified Rankin Scale (MRS). Unit of Measure: MRS score (scale of 1 to 5).

Morbidity Assessment: The Modified Rankin Scale (MRS) will be used to quantify the degree of functional impairment or disability resulting from the acute stroke. The MRS score ranges from 1 to 5, with 1 indicating minimal symptoms and 5 representing severe disability or bedridden status., 1, 3, and 12 months
Secondary Outcome Measures: Demographic Characteristics and Mortality Outcomes, Outcome Measure: Mortality rate stratified by demographic characteristics (age, sex, ethnicity, socioeconomic status).

Unit of Measure: Percentage (%) or number of deaths per group., 1, 3, and 12 months|Type of Stroke and Mortality Outcomes, Outcome Measure: Mortality rate stratified by type of stroke (ischemic, hemorrhagic, other). Unit of Measure: Percentage (%) or number of deaths per stroke type., 1, 3, and 12 months|Clinical History and Mortality Outcomes, Outcome Measure:Mortality rate stratified by clinical history (presence of comorbid conditions, previous strokes, BMI, smoking habits, alcohol consumption). Unit of Measure: Percentage (%) or number of deaths per clinical history category, 1, 3, and 12 months|Laboratory Parameters and Mortality Outcomes, Outcome Measure: Mortality rate stratified by laboratory parameters (e.g., blood glucose levels, cholesterol levels). Unit of Measure: Percentage (%) or number of deaths per laboratory parameter range., 1, 3, and 12 months|Treatment and Mortality Outcomes, Outcome Measure: Mortality rate stratified by type of treatment (e.g., medications, surgical interventions). Unit of Measure: Percentage (%) or number of deaths per treatment type., 1, 3, and 12 months