Strength Training and Muscle Lipids
NCT Number: NCT06480747
Acronym: Strength-Lip
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Healthy
Interventions: OTHER: Resistance exercise training
Sponsor: University of Kansas Medical Center
Collaborators: National Strength and Conditioning Association Foundation
Sex: ALL
Age: CHILD
Enrollment: 30
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Start Date: 2024-07-01
Completion Date: 2025-05-31
Locations: Hoglund Biomedical Imaging Center, Kansas City, Kansas, 66103, United States|Neuromechanics Laboratory, Lawrence, Kansas, 66045, United States|Exercise and Human Performance Laboratory, Overland Park, Kansas, 66213, United States|Metabolic and Body Composition Laboratory, Overland Park, Kansas, 66213, United States

Summary:
The purpose of this study is examine the effects of 8 weeks (3 days/week) of resistance exercise training in children 8 to 10 years of age on muscle strength and power, motor unit activation, and lipid profiles of the vastus lateralis.

Primary Outcome Measures: Change in muscular power of the leg extensors, as measured with isokinetic strength testing., The score will reflect the muscular power of the leg extensors. The higher score, reflects greater muscular strength., Baseline, following the intervention (9 weeks)
Secondary Outcome Measures: Change from baseline in thigh muscle cross-sectional area, Scores are measured cross-sectional area from ultrasound images. The higher score, reflects greater muscle size of the leg extensors., Baseline, following the intervention (9 weeks)
Other Outcome Measures: Change from baseline in intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy, The score will reflect a concentration. The higher score, reflects more fat in the fibers., baseline, following the intervention (9 weeks)|Change from baseline in extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy, The score will reflect a concentration. The higher score, reflects more fat in the fibers., baseline, following the intervention (9 weeks)|Change from baseline in the fatty acid saturation levels of the extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy, The score will reflect a saturation level of fatty acids in the extramyocellular lipid. The higher score, reflects greater fatty acid saturation., baseline, following the intervention (9 weeks)|Change from baseline in the fatty acid saturation levels of the intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy, The score will reflect a saturation level of fatty acids in the intramyocellular lipid. The higher score, reflects greater fatty acid saturation., baseline, following the intervention (9 weeks)|Change from baseline in motor unit activation, as measured with surface electromyography decomposition., The score will reflect the firing rates of recorded motor units. The higher score, reflects greater motor unit activation., baseline, following the intervention (9 weeks)|Change in total body lean mass, as measured with bioelectrical impedance analysis., The score will reflect the lean mass. The higher score, reflects greater lean mass., baseline, following the intervention (9 weeks)|Change in total body fat mass, as measured with bioelectrical impedance analysis., The score will reflect the fat mass. The higher score, reflects greater fat mass., baseline, following the intervention (9 weeks)