Virtual Reality for Advanced Cancer Pain
NCT Number: NCT06534580
Acronym: VRcan
Status: NOT_YET_RECRUITING
Study Type: OBSERVATIONAL
Conditions: Neoplasm Metastasis|Pain|Palliative Care
Interventions: DEVICE: Virtual Reality
Sponsor: University College, London
Collaborators: Velindre NHS Trust|Lancaster University|Brighton and Sussex University Hospitals NHS Trust
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 100
Study Design: Observational Model: |Time Perspective: p
Start Date: 2024-09-01
Completion Date: 2025-11-30

Summary:
Background

Pain is commonly experienced by people who are living with advanced (incurable) cancer. There is evidence to suggest virtual reality could help to relieve this pain: however, this evidence is poor quality with the intervention poorly defined. A robustly co-designed intervention, with people who have advanced cancer and experience pain, will facilitate a better evidence-base.

Aim

To develop and refine a virtual reality intervention that will help people living with advanced cancer to manage pain.

Objectives

1. Explore and establish key components of a virtual reality intervention for people with advanced cancer in terms of effectiveness, acceptability and feasibility using in-depth interviews and focus groups with people living with advanced cancer and experiencing pain.
2. Develop and manualise a virtual reality intervention using co-design methodology.
3. User-test the intervention to refine further.

Methods

Multi-method design, incorporating multiple stakeholder perspectives, over three phases:

Phase I. Focus groups or individual interviews with a total of 40 people, from four locations (Brighton, Cardiff, Liverpool, \& London), who have advanced cancer and experience pain.

They will use the virtual reality intervention and give feedback on what resonated with them and what they would change.

Phase II. Four focus groups (one at each study location) with multiple stakeholders. During this stage, the findings from phase 1 will be presented and a manual will be produced that gives guidelines on use of the virtual reality intervention.

Phase III. Up to 20 people living with advanced cancer and pain will user-test the intervention over an eight-week period. During this phase, the investigators will test if/how often the virtual reality is used as part of routine practice in each site and identify any barriers of use.

Anticipated Impact and Dissemination

1. A robustly co-designed intervention, ready for testing in a larger trial, to assess the clinical and cost effectiveness of virtual reality as a form of pain management.
2. Guidelines for the use of virtual reality in a clinical setting.

The results will be published through academic routes (peer-reviewed publications as well as presented at national and international conferences). The investigators will also work with our group of people with lived experience and an oversight committee to establish the best other routes to disseminate the findings to the public e.g., a social media campaign, leaflets to clinical settings, blog and vlog posts.

Primary Outcome Measures: Data on the use of virtual reality for managing pain, from the perspective of people living with advanced cancer who experience pain., 15 months|A pilot of the intervention, how it will be implemented, and how it is expected to work., 15 months|A user-tested virtual reality intervention with a manual for use, including guidelines for use in clinical settings and research priorities, 15 months