Rapid Eye Movement Restoration and Enhancement for Sleep-deprived Trauma-adaptation
NCT Number: NCT06547086
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Healthy Volunteers
Interventions: DEVICE: Transcranial electrical stimulation with Temporal Interference (TES-TI)
Sponsor: University of Wisconsin, Madison
Collaborators: United States Department of Defense
Sex: ALL
Age: ADULT
Enrollment: 55
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Start Date: 2024-09
Completion Date: 2026-06
Locations: University of Wisconsin, Madison, Wisconsin, 53719, United States

Summary:
The goal of this clinical trial is to find out whether stimulating the brain with electrical current during naps can increase certain kinds of brain activity that happen during sleep and lead to improvements in emotional health and stress resilience.

Participants will attend up to 3 study visits, each of which may last up to 4-5 hours. During these visits, participants will wear a high density electroencephalography (hdEEG) cap and take a nap.

Primary Outcome Measures: Identify effective TES-TI parameters to trigger spindles, Researchers will do a power analysis on high density EEG data for spindle frequency (11-15Hz) and see if there is increase in this frequency range during/post stimulation., Post nap (up to 90 minutes)|Identify effective TES-TI parameters to trigger spindles, Researchers will do a power analysis on high density EEG data for sawtooth wave frequency (3-5Hz) and see if there is increase in this frequency range during/post stimulation., Post nap (up to 90 minutes)|Identify effective duration of the nap to maximize TES-TI effect on REM sleep, Researchers will compare the durations of nap (sleep duration on the EEG) within subjects across their multiple visits, as well as across subjects; correlating this with the stimulation parameters, Post nap (up to 90 minutes)|Change in spindles after effective TES-TI intervention, Changes in sleep spindle density during sleep as measured by portable EEG device., Post nap (up to 90 minutes)|Change in sawtooth waves after effective TES-TI intervention, Researchers will do a power analysis on high density EEG data for sawtooth wave frequency (3-5Hz) and see if there is increase in this frequency range during/post stimulation., Post nap (up to 90 minutes)|Change in score for vigilance task, The vigilance task is a computerized reaction time task where participants are presented with a fixation point on a computer screen. At random, the fixation point will change appearance at which point the participant is to click a provided button as quickly as possible. The latency response is recorded automatically. Faster responses are indicative of higher vigilance., Baseline to post-nap (up to 90 minutes)|Change in sleep quality and mood, Sleep quality and mood will be assessed using the Restorative Sleep Questionnaire (REST-Q), a 9-item questionnaire assessing aspects of restorative sleep. Each item is scored on a 5-point Likert scale, scores range from 9-45. A higher score indicates a more restorative sleep, Baseline to post-nap (up to 90 minutes)|Change in sleepiness, Sleepiness will be measured using the Stanford Sleepiness Scale (SSS). SSS is a measure of subjective alertness on a 7-point scale. A lower score on the scale indicated higher alertness., Baseline to post-nap (up to 90 minutes)|Change in emotion response, Emotional response is measured using an emotional processing task. This task involves viewing a series of emotionally charged images (60 positive, 60 negative, 60 neutral). Participants see a randomized set of these images and are asked to evaluate how pleasant and emotionally arousing each image is on respective 9-point Likert scales, Baseline to post-nap (up to 90 minutes)|Change in Spectral Power in Sawtooth Wave Frequency (3-5Hz), Baseline to 4 weeks|Change in minutes scored as REM sleep, EEG data will be recorded during sleep. The sleep EEG data is separated into stages (REM-NREM). This way, it is known how many minutes they spend in each stage., Baseline to 4 weeks