Effects of Different Anesthesia Machine Modalities on Bariatric Surgery Patients: a Prospective Randomized Controlled Study
NCT Number: NCT06547411
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Ventilation|Bariatric Surgery|Intracranial Pressure|Carbon Dioxide
Interventions: DEVICE: PC Ventilation mode|DEVICE: VC Ventilation mode|DEVICE: PRVC Ventilation mode
Sponsor: Yu-Long Jia
Collaborators: Inner Mongolia Baogang Hospital|The Affiliated Hospital of Inner Mongolia Medical University
Sex: ALL
Age: CHILD, ADULT, OLDER_ADULT
Enrollment: 90
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Start Date: 2023-07-12
Completion Date: 2024-12-30
Locations: Inner Mongolia Baogang Hospital, Baotou, Inner Mongolia, 014010, China

Summary:
The goal of this clinical trial is to explore the clinical significance and value of the PRVC ventilation mode in Bariatric Surgery Patients. The main questions it aims to answer are：

* Do different ventilation patterns affect intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients?
* Does PRVC mode reduce intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients?
* Whether intracranial pressure can be quickly measured by monitoring a patient's optic nerve sheath diameter (ONSD)？ Researchers randomized bariatric surgery patients into PC, VC, and PRVC groups for comparison, looking at breathing mechanics, PaCO2, and ICP.

Participants will:

* take PC mode ventilation, VC mode ventilation, and PRVC mode ventilation
* monitor Respiratory mechanics, PaCO2, and ONSD

Primary Outcome Measures: optic nerve sheath diameter [ONSD], Patients were positioned supine with their eyes softly closed, and their eyes were protected with disposable transparent patches. A 7.5 MHz linear probe (Micromaxx Ultrasound System; SonoSite Inc., Bothell, WA, USA) was gently placed on the closed upper eyelid without applying pressure to the eyeball, and sufficient ultrasound gel was applied to ensure clear imaging. The optic nerve sheath was checked and measured 3 mm beyond the globe, and three ONSD measures were performed, with the average value utilized as the final ONSD measurement, which was accurate to 0.01 mm., 1 year|carbon dioxide partial pressure, Arterial blood carbon dioxide partial pressure, is an important indicator of alveolar ventilation, reflecting the respiratory factors in acid-base balance. Its reference value is usually 35-45 mmHg., 1 year|mean airway pressure (PAWM), Mean airway pressure throughout the ventilation cycle, 1 year|peak airway pressure (PAP), Maximum pressure in the airway throughout inspiration, 1 year|esophageal pressure (PES), Esophageal manometry is the recording of pressure changes in various parts of the esophagus at rest and after swallowing, and is used to indicate the motor function of the upper and lower esophageal sphincters and the body of the esophagus, and to understand esophageal motility, 1 year|tidal volume (TV), Tidal volume is the volume of gas inhaled or exhaled each time when breathing calmly, it is an indicator to show lung volume, mainly used for ventilation function test in pulmonary function test. Tidal volume is the basis for assessing lung function and ventilation efficiency, and is an important indicator of lung volume, 1 year|mean arterial pressure (MAP), Mean arterial pressure is the average push given by the heart to blood flow throughout the cardiac cycle, with systolic pressure being the peak pressure and diastolic pressure being the pressure nadir., 1 year|heart rate (HR), The normal adult heart rate ranges from 60 to 100 beats per minute, but infants and children have a faster heart rate than adults., 1 year