High Altitude (HA) Residents With High Altitude Pulmonary Hypertension (HAPH), Pulmonary Artery Pressure (PAP) Assessed at HA (3200 m) vs LA (760 m)
NCT Number: NCT06489704
Status: NOT_YET_RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: High Altitude Pulmonary Hypertension
Interventions: OTHER: Echocardiography
Sponsor: University of Zurich
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 24
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Start Date: 2024-07-01
Completion Date: 2024-12-31
Locations: Aksay Medical Center, Aksay Plateau, Naryn, Kyrgyzstan, Kyrgyzstan, Kyrgyzstan

Summary:
To study the effect of relocation from 3200 m (Aksay) to 760 m (Bishkek) in patients with high altitude pulmonary hypertension (HAPH) who permanently live \>2500 m on pulmonary artery pressure (PAP)

Primary Outcome Measures: Change in Pulmonary artery Pressure (PAP) after the first night at 760 m (LA) vs at 3200 m (HA), Change in RV/RA in mmHg assessed by echocardiography between LA (760 m) vs High altitude (3200 m), day 2 at 760 m vs. 3200 m
Secondary Outcome Measures: Change in Pulmonary artery Pressure (PAP) after seven nights at 760 m (LA) vs at 3200 m (HA), Change in RV/RA in mmHg assessed by echocardiography between LA (760 m) vs High altitude (3200 m), day 7 at 760 m vs. 3200 m|Cardiac output at 760 m (LA) vs at 3200 m (HA), Change in cardiac output in l/min assessed by echocardiography between LA (760 m) vs HA (3200 m), day 2 and 7 at 760 m vs. 3200 m|Tricuspid pressure gradient by echocardiography at 760 m (LA) vs at 3200 m (HA), Tricuspid pressure gradient assessed by echocardiography between LA (760 m) vs HA (3200 m), day 2 and 7 at 760 m vs. 3200 m|Tricupsid annular plane systolic excursion by echocardiography at 760 m (LA) vs at 3200 m (HA), Tricupsid annular plane systolic excursion assessed by echocardiography between LA (760 m) vs HA (3200 m), day 2 and 7 at 760 m vs. 3200 m|pH by arterial blood gases at 760 m (LA) vs at 3200 m (HA), Change in pH by arterial blood gases assessed between LA (760 m) vs HA (3200 m), day 2 and 7 at 760 m vs. 3200 m|partial pressure of oxygen (PaO2) by arterial blood gases at 760 m (LA) vs at 3200 m (HA), Change in partial pressure of oxygen (PaO2) assessed by arterial blood gases between LA (760 m) vs HA (3200 m), day 2 and 7 at 760 m vs. 3200 m|partial pressure of carbon dioxide (PaCO2) by arterial blood gases at 760 m (LA) vs at 3200 m (HA), Change in partial pressure of carbon dioxide (PaCO2) assessed by arterial blood gases partial pressure of carbon dioxide (PaCO2) between LA (760 m) vs HA (3200 m), after the first and seventh night at LA|Change in right to left heart diameter ratio at 760 m (LA) vs at 3200 m (HA), Change in right to left heart diameter ratio assessed by echocardiography between LA (760 m) vs HA (3200 m), day 2 and 7 at 760 m vs. 3200 m|Change in right atrial area at 760 m (LA) vs at 3200 m (HA), Change in right atrial area by echocardiography between LA (760 m) vs HA (3200 m), day 2 and 7 at 760 m vs. 3200 m|Change in right heart strain at 760 m (LA) vs at 3200 m (HA), Change in right heart strain by echocardiography between LA (760 m) vs HA (3200 m), day 2 and 7 at 760 m vs. 3200 m|Change in ECG morphology at 760 m (LA) vs at 3200 m (HA), Change in ECG morphology and QT-interval by 12-lead ECG between LA (760 m) vs HA (3200 m), day 2 and 7 at 760 m vs. 3200 m