The Bern Rehab Registry
NCT Number: NCT06516172
Acronym: BernRehabReg
Status: RECRUITING
Study Type: OBSERVATIONAL
Conditions: Cancer|Cardiovascular Diseases|Musculoskeletal Diseases|Pulmonary Disease
Interventions: OTHER: Comprehensive disease-specific rehabilitation
Sponsor: Insel Gruppe AG, University Hospital Bern
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 30000
Study Design: Observational Model: |Time Perspective: p
Start Date: 2020-12-01
Completion Date: 2030-12
Locations: Berner Reha Centre, Centre for Rehabilitation & Sports Medicine, Insel Group, Heiligenschwendi, Bern, 3625, Switzerland|Reha Inselspital, Bern University Hospital, Centre for Rehabilitation & Sports Medicine, Insel Group, Bern, 3010, Switzerland

Summary:
This study examines the health outcomes of patients with long-term illnesses such as cancer, heart, lung, or musculoskeletal diseases who participate in a rehabilitation programme. The programme may involve staying in a facility (inpatient), visiting a facility (outpatient), home-based care supported by digital health tools (telerehabilitation), or a combination of facility- and home-based options.

The key health outcomes being measured include physical fitness and strength, body composition (like body fat and muscle mass), specific risk factors related to the diseases, and patients' self-reported health and experience outcomes, such as feelings of anxiety, depression, fatigue, overall quality of life, and satisfaction with the rehabilitation programme.

These measurements provide important information about the patients' lung, heart, and muscle health, as well as their mental well-being. They also help to predict the likelihood of further health complications, the chance of needing to be hospitalized again, and overall quality of life. This information is useful for improving the quality of care, tailoring future provision of rehabilitation services and long-term care for patients with chronic conditions.

Additionally, the study will provide insights into how new technologies like telerehabilitation are implemented, including how well they are adopted, followed, and accepted by patients.

Primary Outcome Measures: Short-term change (absolute and percentage) in cardiorespiratory fitness, measured as peak oxygen uptake (ml/min/kg) or 6 minute walking test (m), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes)|Long-term change (absolute and percentage) in cardiorespiratory fitness, measured as peak oxygen uptake (ml/min/kg) or 6 minute walking test (m), Stratified by type of delivery and cohort, From discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) to one year follow-up
Secondary Outcome Measures: Short- and long-term change (absolute and percentage) in muscle strength, measured by grip strength (kg), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term change (absolute and percentage) in muscle mass index, measured by body impedance analysis (kg/height2), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term change (absolute and percentage) in the Extended Barthel Index (EBI, range from 0 to 64) or the Functional Independence Measure (FIM, range from 0 to 126), higher values indicate better levels physical and/or mental functioning, In patients participating in inpatient rehabilitation, stratified by cohort, From rehabilitation entry to discharge (3 weeks) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in markers of anxiety, measured by Generalized Anxiety Disorder-7 questionnaire score (range from 0 to 21, higher values indicate more severe anxiety), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in markers of depression, measured by Patient Health Questionnaire-9 score (range from 0 to 27, higher values indicate more severe depression), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in markers of health-related quality of life, measured by Kansas City Cardiomyopathy Questionnaire-23 score (range from 0 to 100, higher values indicate better QoL), In patients with heart failure, stratified by type of delivery, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in markers of health-related quality of life, measured by HearQoL questionnaire score (range from 0 to 3, higher values indicate better QoL), In patients with heart disease participating in outpatient cardiac rehabilitation or telerehabilitation, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in markers of health-related quality of life, measured by MacNew questionnaire score (range 0 to 7, higher values indicate better QoL), In patients with heart disease participating in inpatient cardiac rehabilitation, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in markers of health-related quality of life, measured by Chronic Respiratory Disease Questionnaire score (range 1 to 7, higher values indicate better QoL), In patients with pulmonary disease, stratified by type of delivery, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in markers of health-related quality of life, measured by Functional Assessment of Cancer Therapy-General questionnaire score (range 1 to 5, higher values indicate better QoL), In patients with cancer, stratified by type of delivery, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in office systolic blood pressure (mmHg), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in LDL-cholesterol (mmol/l), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in HbA1c (percentage), Composite outcome, stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in hsCRP (mg/l), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in body mass index (kg/m2), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in body fat, assessed by body impedance analysis (%), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in steps per day, assessed by wrist-worn accelerometer (n), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in smoking status, assessed by questionnaire (current, former, non-smoker), Composite outcome, stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Short- and long-term changes (absolute and percentage) in adherence to guideline-directed medical therapies (percentage of recommended medical substances taken), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and from discharge to one year follow-up|Return to work (yes, no), Stratified by type of delivery and cohort, At rehabilitation discharge (3 weeks for inpatient, 12 weeks for outpatient programmes) and at one year follow-up
Other Outcome Measures: Time trends of proportion of patient participating in digitally-enhanced or digital/telerehabilitation (percentage), Stratified by type cohort, 12 months|Assessment of patient reported experience measures (PREMS) by a self-designed questionnaire on satisfaction with the rehabilitation programme (range 1 to 10, higher values indicate higher satisfaction), Stratified by type of delivery and cohort, From rehabilitation entry to discharge (3 weeks for inpatient, 12 weeks for outpatient programmes)