Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After VATS Lung Resection
NCT Number: NCT06500949
Status: RECRUITING
Study Type: INTERVENTIONAL
Phases: NA
Conditions: Postoperative Cough|Thoracoscopy|Pulmonary Resection|Vagus|Nerve Block
Interventions: PROCEDURE: Vagus Nerve Pulmonary Branch Block|PROCEDURE: Vagus Nerve Pulmonary Branch Injection
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sex: ALL
Age: ADULT, OLDER_ADULT
Enrollment: 104
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2024-07-15
Completion Date: 2025-07
Locations: Second affiliated Hospital School of Medicine,Zhejiang University, Hangzhou, Zhejiang, China

Summary:
Postoperative cough after pulmonary resection is a common issue seen after thoracic surgeries, hindering patients' recovery and affecting their postoperative quality of life. While vagus nerve pulmonary branch block has been known to reduce intraoperative coughing, its impact on postoperative cough post lung resection is uncertain. This study aims to assess the effects of vagus nerve pulmonary branch block on postoperative cough after VATS lung resection. A randomized controlled trial involving 104 thoracoscopic lung resection patients will assign them randomly to a vagus nerve pulmonary branch block group or a control group. The primary outcome measure is the postoperative cough incidence 3 weeks after lung resection. The secondary outcomes include assessing hoarseness in PACU, peak expiratory flow (PEF) on the first post-op day, NRS scores for cough, and LCQ-MC scores at 3 weeks post-surgery, as well as cough occurrence, NRS scores, and LCQ-MC scores at 8 weeks post-procedure.

Primary Outcome Measures: Incidence of postoperative cough following lung resection at 3 weeks post-operation, The incidence of post-lung resection cough was assessed at 3 weeks postoperatively., at 3 weeks post-operation
Secondary Outcome Measures: Condition of hoarseness in PACU, Assessment of hoarseness in PACU following surgery, during in PACU, an average of 1 hour|Peak expiratory flow rate on postoperative day 1, Measurement of peak expiratory flow on postoperative day 1, on postoperative day 1|Numerical Rating Scale for cough intensity at 3 weeks post-operation, The scale ranges from 0 to 10, with 0 indicating no cough and 10 representing the worst imaginable cough.Higher scores on the Numerical Rating Scale for cough intensity indicate a more severe cough condition., at 3 weeks post-operation|Leicester Cough Questionnaire for Measuring Chronic Cough at 3 weeks post-operation, The LCQ-MC score ranges from a minimum of 0 to a maximum of 21, with three dimensions: physical, psychological, and social. Each dimension is scored from 1 to 7, and the total score is the sum of the three dimensions.Higher scores on the LCQ-MC indicate better health-related quality of life. A score of 0 represents the worst possible quality of life, while a score of 21 represents the best possible quality of life in relation to cough., at 3 weeks post-operation|Incidence of postoperative cough following lung resection at 8 weeks post-operation, The incidence of post-lung resection cough was assessed at 8 weeks postoperatively., at 8 weeks post-operation|Numerical Rating Scale for cough intensity at 8 weeks post-operation, The scale ranges from 0 to 10, with 0 indicating no cough and 10 representing the worst imaginable cough.Higher scores on the Numerical Rating Scale for cough intensity indicate a more severe cough condition., at 8 weeks post-operation|Leicester Cough Questionnaire for Measuring Chronic Cough at 8 weeks post-operation, The LCQ-MC score ranges from a minimum of 0 to a maximum of 21, with three dimensions: physical, psychological, and social. Each dimension is scored from 1 to 7, and the total score is the sum of the three dimensions.Higher scores on the LCQ-MC indicate better health-related quality of life. A score of 0 represents the worst possible quality of life, while a score of 21 represents the best possible quality of life in relation to cough., at 8 weeks post-operation