owencqueen/cgbench_data huggingface dataset:
Gene: PALB2 (HGNC:26144)
Evidence Code: BP4 — Supporting
Modification Type: General recommendation
● Protein: Do not use. So far, published predictors have yet to achieve functional outcome for PALB2 missense variants 


● RNA: At least one well-established in silico predictor (e.g. SpliceAI) shows no impact on splicing 


o NOTE: Splice analysis needs to be considered for all variant types (including missense, frameshift, nonsense, etc. as any variant has the potential to impact splicing which may preclude any expected protein effects) 


o NOTE: BP4 for splice predictions may not be applied in conjunction with BP7_Variable(RNA) (a lack of observed RNA defect) 


o Use caution in applying the wrong type of computational evidence (protein vs. RNA) towards the cumulative body of evidence for the opposite mechanism.