owencqueen/cgbench_data huggingface dataset:
Expression A
Evidence showing the gene is expressed in tissues relevant to the disease of interest and/or is altered in expression in patients who have the disease. This category is specific to methods to detect RNA transcripts (RNAseq, microarrays, qPCR, qRT-PCR, Real-Time PCR). An example scenario to consider for altered expression in patients includes studies in which expression of the gene of interest (and even additional genes) is examined in tissue and/or cell samples obtained from individuals with the disease of interest in which the molecular etiology of the individual is unknown. For instance, tissue samples from 10 individuals diagnosed with hypertrophic cardiomyopathy were examined by western blot analysis and found that gene X was reduced in the heart cells of all patients. Expert reviewers may specify appropriate uses of this category in the context of their particular disease domain. For example, groups may choose to award points based on the specificity of expression in relevant organs.
Expression B
Evidence showing the gene is expressed in tissues relevant to the disease of interest and/or is altered in expression in patients who have the disease. This category is specific to methods to detect protein expression (western blot, immunohistochemistry). An example scenario to consider for altered expression in patients includes studies in which expression of the gene of interest (and even additional genes) is examined in tissue and/or cell samples obtained from individuals with the disease of interest in which the molecular etiology of the individual is unknown. For instance, tissue samples from 10 individuals diagnosed with hypertrophic cardiomyopathy were examined by western blot analysis and found that gene X was reduced in the heart cells of all patients. Expert reviewers may specify appropriate uses of this category in the context of their particular disease domain. For example, groups may choose to award points based on the specificity of expression in relevant organs.