user: DIALOG:
What are the main types of cells affected by NNK?
- Once NNK is activated, NNK initiates a cascade of signaling pathways (for example ERK1/2, NFκB, PI3K/Akt, MAPK, FasL, K-ras), resulting in uncontrolled cellular proliferation and tumorigenesis.
- What other effects did NNK have on cells?
- NNK activates µ en m-calpain kinase which induce lung metastasis via the ERK1/2 pathway.
- What do you find most interesting about the article?
- This pathway upregulate cellular myelocytomatosis (c-Myc) and B cell leukemia/lymphoma 2 (Bcl2) in which the two oncoprotein are involved in cellular proliferation, transformation and apoptosis.
- Does NNK affect only a few cells?
- Also does NNK promotes cell survival via phosphorylation with cooperation of c-Myc and Bcl2 causing cellular migration, invasion and uncontrolled proliferation.
- What other things did you find interesting?
- The ERK1/2 pathway also phosphorylate NFκB causing an upregulation of cyclin D1, a G1 phase regulator protein.
- Do other cells suffer from this?
- 
Next turn: When NNK is present it directly involves cellular survival dependent on NFκB. Further studies are needed to better understand NNK cellular pathyways of NFκB.


Problem: What could be the response? DIALOG:
What is Achabou?
- 
A: Achabou Achabou () is a village in the commune of Tafreg, in Bordj Bou Arréridj Province, northern Algeria.


QUESTION: Write another turn of this conversation. DIALOG:
What teams were ranked in the top 10 in the NCAA University Division?
- 1969 NCAA University Division football rankings Two human polls comprised the 1969 National Collegiate Athletic Association (NCAA) football rankings.
- Are there any other interesting aspects about this article?
- Unlike most sports, college football's governing body, the NCAA, does not bestow a national championship, instead that title is bestowed by one or more different polling agencies.
- What are the different polling agencies?
- There are two main weekly polls that begin in the preseason—the AP Poll and the Coaches' Poll.
- Are there any other interesting aspects about this article?
- 
ANS: The final UPI Coaches Poll was released prior to the bowl games, in early December.<br>One coach on the 35-member board did not vote.<br > Texas received 28 of the 34 first-place votes; Penn State received four and one each went to USC and Nebraska.


question: Write a response. DIALOG:
What is the Mosby Heritage Area Association?
- Mosby Heritage Area Association The Mosby Heritage Area Association was founded in 1995 in Middleburg, Virginia, as a membership-driven 501(c) 3 nonprofit preservation and historic organization.
- What is it for?
- MHAA's mission is to educate about, and advocate for, the preservation of the extraordinary historic, cultural and scenic resources in the Northern Virginia Piedmont.
- Are there any other interesting aspects about this article?
- Although MHAA is interested in the complete history of the area, it is named for the famed Confederate Cavalry officer John S. Mosby, whose rangers fought throughout the region during the American Civil War.
- Why was it named after him?
- As a history-oriented organization MHAA is focused on the complete history of the area, although the Civil War always will be a crucial part of the area's past, since so much of the war took place in Virginia.
- Is there anything else noteable about the association?
- The Mosby Heritage Area was hit hard by the war, and an important part of the Association's mission is to study and teach its history, not to romanticize it.
- Do they have any upcoming events?
- 
response: The Association's annual Civil War Conference, held each October, brings the nation's top scholars in the field for a weekend of lectures and field trips.


Q: See the conversation. DIALOG:
What is known about the song Man of a Thousand Faces?
- Man of a Thousand Faces (song)  "Man of a Thousand Faces" is the lead single from British neo-progressive rock band Marillion's ninth studio album "This Strange Engine", released on 2 June 1997 by Castle Communications imprint Raw Power.
- Are there any other interesting aspects about this article?
- It was the band's first single since they departed from EMI Records in 1995.
- What happened in the year 1997?
- Reflecting the decline in popularity for Marillion, the song reached only the number 98 on the UK Singles Chart.
- What other aspects are there in this article?
- 
****
Next: A music video was created for "Man of a Thousand Faces".


DIALOG:
What is the Rotowhenua River?
- Rotowhenua River The Rotowhenua River is a river of the Northland Region of New Zealand's North Island.
- What does it flow into?
- 
Next turn:

assistant: A short, broad river, it flows into the Awaroa River to form a northern arm of the Whangape Harbour.