{"text":""Tapering doses" protocol arm was not effective for treatment retention outcome.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"1 Indication for further investigations (brain ultrasound). 2 Change of study design to\u00ca efficacy study with historical control group.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"1. Very low enrollment rate. \u00ca \u00ca 2. Recent studies question the effect of adding panitumumab in this category of patients. \u00ca \u00ca 3. Too high toxicity rate","label_descriptions":["Insufficient_Enrollment","Safety_Sideeffects","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"10\/2005 PI assigned duties as trauma physician in addition other duties","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"12\/15\/2008 Voluntarily placed on inactive status-requested by the PI","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"13 of 15 patients recruited.Study patients responded with no safety signals. Recruitment\u00ca slow,timely end of study necessary to keep development timelines","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"2 complications with midazolam","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"20 subjects completed for a pilot, further funding required to continue study\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"2011 Thailand flooding led to loss of GMP pharmacy, project delays, and further regulatory \u00ca challenges.","label_descriptions":["Logistics_Resources","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"36 cases were included and the 4 centers and they are unable to increase their recruitment to obtain the 400 cases necessary to reach statistical significance.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"5 immune related serious adverse events in Phase 1 study","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"50% of eligible patients refused to enter the study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"6 month vital status report not collected after 28 day follow up analysis indicated no difference between placebo & tezosentan","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"65 patients were included after 2 years instead of 140","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"7% enrollment. Study terminated after a small number of recruited patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A 300 patient safety analysis by the Data Monitoring Committee showed a trend towards higher mortality in the treatment group.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A business decision was made to not initiate this study.","label_descriptions":["Business_Administrative","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A cluster of adverse events in everolimus arm was noted.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A cluster of deaths in the BCG-arm compared with controls","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A decision was made to discontinue the study due to a change in the strategic direction of the company.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A decision was made to not move forward with the study. No participants were enrolled or \u00ca treated.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A higher rate of late rejection was seen in the low tacrolimus arm.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A lack of a potential patient.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"A new alternative treatment caused the decrease in the rhythm of recruitment.","label_descriptions":["Insufficient_Enrollment","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A new alternative treatment for patients who have progressed after treatment with trastuzumab, has caused the decrease in the rhythm of recruitment.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"A new protocol was developed to replace this protocol in 2008, with removal of ATG and\u00ca extension of MMF duration.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"A new study has began recently","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A new study is being designed. No patients were enrolled.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A paper on the same topic came out just before we wanted to start our study.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A pending new protocol will replace this study.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"A planned interim analysis was performed after approx. 240 subjects completed the trial. The study was stopped, as permitted by protocol, after the analysis.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A preliminary analysis of 11 patients confirmed the safety profile of NCX-1000 but did not demonstrate the efficacy required.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A re-evaluation of research risks to participants were greater than originally anticipated","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"A significant reduction in head injuries coupled with more frequent use of crainectomy reduced \u00ca the number of potential subjects.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"A sister study using Frova at a 10 mg dose had adverse effects.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"AG-1749 superior to Gefarnate in ulcer prevention","label_descriptions":["Success","Endpoint_Met","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"AMAG not continuing with Combidex, the study drug\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"AML assessment of response in the Part B patients (9) find treatment failure in all instances.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"AOI Pharma is reassessing the development strategy for perifosine.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"AOI Pharmaceuticals, Inc. decided to terminate the license agreement. No further clinical development by AOI Pharmaceuticals, Inc. will be pursued.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"APPRISE closure prompted by SWOG S0205 not meeting primary endpoint-improving OS. APPRISE enrollment closure due to similar design;no unexpected safety data","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"AVE5530 in hypercholesterolemia was stopped due to insufficient efficacy","label_descriptions":["Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"AZ decision to discontinue fostamatinib development in RA; rights to fostamatinib returned to \u00ca Rigel Pharmaceuticals.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"AZD1704 has essentially similar PK profile in Japanese subjects as in Caucasians. One of the main purposes of the study has thereby been achieved.","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Abandoned due to lack of recruitment Oct 2006","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Abnormality prevalence revealed to be much lower than expected.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Absence of patients for recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"According to the study design, in the first step the number of responses was lower than the number required (< 7).\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual Goal Met","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual and treatment with CG1940\/CG8711 stopped due to IDMC recommendation.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual factor","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual goal for interventional part not achievable","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual has been very slow. We are currently determining whether or not to keep the trial going as is or to close the trial and write a new protocol.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual is suspended due to COVID-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual is very poor","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual problems","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual rate was too low","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual too difficult to meet","label_descriptions":["Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual was not optimized","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrual was suboptimal and increasing the number of patients was not feasible.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Accrural was completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Achieving site readiness and enrolling the trial within a reasonable time","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Acrrual target was not being met","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Active Duty principle investigator currently deployed","label_descriptions":["Business_Administrative","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Additional equipment is needed.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Additional research","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Administrative","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Administrative closed due to funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Administrative reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Administrative reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Administrative suspension","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Administratively complete.","label_descriptions":["Business_Administrative","Endpoint_Met","Invalid_Reason","Success"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Adult patient population barriers.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Adverse Events","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Adverse findings from nonclinical carcinogenicity studies.","label_descriptions":["Safety_Sideeffects","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After 1 year only 2 subjects enrolled and treated thus no meaningful efficacy analyses could be performed.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After 190 weeks [7 patients left] it was terminated for administrative reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After IELSG25A study amendment, patients subject of the present study were eligible for inclusion in the IELSG25A study\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After Preliminary results indicate need to make numerous changes to protocol, and therfore will end, rewrite, and then begin again.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"After a discussion, we decided to withdraw the study.\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After an extensive review,the ASPIRE in CKD study was terminated because it was not possible to complete the study in an appropriate time frame.\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After an extensive review,the ASPIRE in CKD study was terminated because it was not possible\u00ca to complete the study in an appropriate time frame.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After initiation of study many studies reported an equivalence of SNB and ALND which led to \u00ca widespread adoption of the former as standard procedure.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After interim analysis it was determined that the risks were too great in comparision to the\u00ca results","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After interims analysis standard errors for inflammatory and nutritional markers varied \u00ca widely, that the power calculation required unattainable goals","label_descriptions":["Study_Design","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"After pilot study no difference in the primary end point was found between the two primary.\u00ca Non-inferiority trial not deemed feasible.","label_descriptions":["Logistics_Resources","Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"After primary completition date, experimental drug was no longer available","label_descriptions":["Logistics_Resources","Study_Design","Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"After reports of turbidity in urine in 4 of 8 volunteers in the 4th cohort, the study was halted temporarily.\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After review of safety events and have decided that further dose escalation of MEDI-507 as a single agent is not feasible.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After treatment of 7 patients, it was decided that the handling characteristics of the test device should be upgraded before continuing the trial as planned.\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After utilizing all available recruitment resources, it was determined that the recruitment goal for the study could not be achieved\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"After year 1, there was insufficient statistical power to detect a difference in the primary outcome measure during planned study period.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Aims of the study re-evaluated, did not justify allocation of resources.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"All AstraZeneca sponsored clinical trials of AZD8931 have been halted","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"All enrollment, treatment, follow-up & data analysis completed\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"All of the mentioned aim and objectives were achieved before the February 2007","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"All patients during the study period were subjected to peripheral blocks or were excluded from\u00ca the study due to exclusion criteria","label_descriptions":["Endpoint_Met","Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"All patients recruited","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"All sites have been put on hold due to the ongoing COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"All subject enrollment\/follow up is on hold due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"All the patients were included","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Alternate study projected to assess imaging endpoints versus clinical endpoints.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Alternative trial planned","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Amendment requested for this study - waiting for Regulatory Approval of the Amendment","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Amgen decision following interim review of efficacy and safety data from the AMG 337 program.","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Amgen determined no further need for this study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"An alternative joint industry effort will provide information on combination versus single\u00ca agent therapy for treatment of aspergillosis","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"An endpoint difference between 3 energies was not observed. Correlations between recovery and ATP were established, and will be used for a Whole Blood system.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"An independent DMC determined continuation was unlikely to demonstrate a statistically significant advantage of ASP8825 over placebo on the primary endpoint","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"An interim analysis revealed a significantly higher persistence\/recurrence of complications of portal hypertension in the 8 mm-stent group.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"An interim analysis showed that nitric oxide patches are not enough effective","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"An interim data analysis found no significant difference between testing groups.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Analysis of data from 104RA202 failed to meet primary endpoint","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Analysis of data from 104RA203 failed to meet primary endpoint.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Ancillary data being reviewed to determine if this study will continue.","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Angioscanners in excess of the SNA group because of use of thiopental","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Animal Safety Data","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Animal Toxicity Findings","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Another study enrolling the similar group of patient are ongoing","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Another study has been planned, so we did not initiate this one.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Another study was opened.","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Another treatment found efficacious","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Another trial in the department directly competes for the the same patient population","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Anticipated number of patients not achieved. All Patients recruited in the study completed all study visits.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Anticipation of inadequate recruitment according to current format.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Approval lapse","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Arm A - reached goal; Arm B - poor accrual","label_descriptions":["Insufficient_Enrollment","Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"As Continuing Review application to IRB was not submitted on time","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"As another Mps1 inhibitor was being developed in parallel, the strategic decision was to move\u00ca forward with the development of the follow up compound only.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"As no safety warnings were detected,Interim analysis from the first 40 patients reccomends to stop the trial for futility\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"As recommended by the DSMB.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"As the recruitment rate was very low, a futility study was conducted and it was decided to\u00ca discontinue inclusions","label_descriptions":["Insufficient_Enrollment","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Assessing resources needed to extend study.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"AstraZeneca has discontinued the development of AZD0530. No new AstraZeneca-sponsored clinical studies will be initiated..","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"AstraZeneca withdrew support for the study.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"At half the sample size, the results were negative with no benefit demonstrated with \u00ca adenosine.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"At interim analysis the study did not meet the response criteria to continue","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"At sponsor's discretion","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"At the end of the year 2002, Cameroon switched from chloroquine to amodiaquine as first-line therapy for of uncomplicated malaria.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"At the first prespecified interim analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Attendance at study sites carries risk of COVID-19 infection. Non-attendance at planned study","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Authorization denied","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Autorities vorbidden this dispositif in other trial","label_descriptions":["Study_Design","Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Availability of Investigational agent","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Avastin approved for first-in-line treatment.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Awaiting IMP license for new GMP suite.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Azidus, the CRO hired for this study by Prevent Senior has lost the interest to conduct this\u00ca study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"B2151007 was prematurely discontinued due to Pfizer's change in prioritization for the\u00ca portfolio and is not due to any safety concerns or regulatory interaction","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"BMS withdrew support and required this trial to stop enrolling; Phase II portion never began,\u00ca only a Phase I trial.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on Independent Data Monitoring Committee (IDMC) recommendation.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on a business decision unrelated to any safety concerns.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on a consistently low enrolment rate and procedural challenges that were unknown at study start. It was not based on safety or efficacy concerns.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on an interim data review, the DSMB concluded that the vaccine cannot be shown in this trial to prevent HIV infection or affect the course of the disease.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on analyses in Phase I, the study did not advance to Phase II.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on analysis of results and consideration of available treatments, the overall benefit to\u00ca risk profile of ocrelizumab was not favorable in RA.","label_descriptions":["Business_Administrative","Negative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on data collected, the combination appeared to be poorly tolearated.\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on futility analysis showing <30% chance of meeting primary endpoint.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on input from regulatory agencies, it is not necessary to conduct this study. An ongoing study was sufficient for regulatory purposes.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on interim analysis at the end of Stage 1, and predefined stopping rules for futility, further enrollment was stopped due to lack of efficacy\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on interim analysis at the end of Stage 1, and predefined stopping rules for futility,\u00ca further enrollment was stopped due to lack of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on overall benefit-risk assessment.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on preliminary parent study results","label_descriptions":["No_Context","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on the data and observed benefit-risk profile, the trial's independent oversight committee recommended that enrollment not resume.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on the data collected, the combination of bevacizumab and sunitinib appeared to be poorly tolerated.\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on the outcome of the planned first interim analysis, it was decided not to continue the trial. No safety concerns were identified.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based on the results of the Phase 1 data, the company decided not to pursue the development of\u00ca this drug at this time.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Based upon preliminary safety and efficacy results from a similar study.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Bayer Healthcare is no supplying the study drug","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Bayer terminated the program and sold the IP to Medronic","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Beacuse of unexpected administrative barriers, only 5 cases were enrolled in a year.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of a strategic decision by Novartis","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of approval of Bevacizumab, it was difficult to perform clinical study in 1st line setting.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of lack of funding and recruitment problems the study has been closed.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of many competing trials using the same mechanism of action, but being further advanced\u00ca in development","label_descriptions":["Business_Administrative","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of negative results of the sister study NAK-06 and the low overall response rate at\u00ca week 24.","label_descriptions":["Another_Study","Negative"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of reconsideration of using erlotinib(EGFR Tyrosine kinase inhibitor) as adjuvant aim","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of slow recruitment; Despite the study was started long time ago (Oct 2004), we have not reached the projected number of patients (150 patients)\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of the economic consequences of the COVID-19 pandemic 2020","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of the epidemic of COVID-19, the serum testing could not be continued","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of the low probability of achieving the primary endpoint.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of unexpectedly reduced disease prevalence in the study area, a pragmatic decision was taken to terminate recruitment in March 2003.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of unsatisfactory results of previous trial which assessed the effect of different onset times of PDL on surgical scars.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of very slow rate of enrollement","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because of withdrawal of Avandia sale due to its risks outweigh its benefits","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because only a few patients follow the inclusion and exclusion criteria.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Because there was no longer an active laboratory component to this study.","label_descriptions":["Logistics_Resources","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Because we did not find funds to do it","label_descriptions":["Business_Administrative","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Big difficulties to enroll patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Boston Scientific has decided to close the Study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Both sponsor and UCSF decided this study was not clinical relevant at this time","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Budget issues","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Budgetary","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Budgetary restrictions","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Bupivacaine has recently been shown to inhibit osteoclast formation in vitro.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business Decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business Decision; No Safety Concerns","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business Decision; No Safety Or Efficacy Concerns.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business Objectives Changed","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business Objectives Have Changed","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business Reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business considerations in light of slow enrollment.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business decision related to efficacy rather than tolerability limitations, not stopped for any\u00ca safety reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business decision to end program","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business decision to stop the program","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business decision. No patients were enrolled","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business decision. Study never started","label_descriptions":["Business_Administrative","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business development reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business objectives changed.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Business reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"CDC's decision to down-select vaccine development to single candidate, ACAM2000\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"CO Phase 2 data did not show sufficient improvement in cath opening at higher dose\/concentration evaluated. Nuvelo ended further clinical dev of alfimeprase.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID -19 HOLD","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID 19 outbreak","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 HOLD","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 Hold","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 Pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 Pandemic Measures","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 outbreak","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 outbreak, we have decided to discontinue the study.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 pandemic.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 precautions","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 restrictions","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19 social distancing requirements","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID-19; Temporary suspension of non-essential human subjects research","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID19 Suspension","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"COVID19-pandemic- Need to minimize exposure. Effects of steroids on COVID19 positive patients","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Cancelled Before Enrollment","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Cancelled before enrollment","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Cancelled before first patient enrolled","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Carisbamate partial onset seizures studies lacked consistent efficacy data so trials in this indication were terminated.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Ceased production of the study drug, Lymphoglobulin. Recruitment of patients onto the trial\u00ca was too slow.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Celgene terminated its collaboration agreement with MethylGene for the development of MGCD0103. All Celgene-sponsored trials with MGCD0103 will be closed.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Celgene terminated its collaboration agreement with MethylGene for the development of MGCD0103. All Celgene-sponsored trials with MGCD0103 with be closed.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Celgene unable to continue funds.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Challenging data collection","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change company strategy","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change development strategy","label_descriptions":["Logistics_Resources","Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in Belgian law on the use of hMG in IUI","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in Formulation","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in available resources for study procedures","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in company direction","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in company strategy","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in drug product development strategy","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in formulation","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in institutional headquarters for the US study.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Change in isolation method","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in patient population no longer fit study criteria.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in strategy regarding the product by the company","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in strategy.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in the development plan for the anti-OX40 antibody.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in the procedure of cells infusion to be approved by the regulatory authority.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Change in treatment priorities for these disease types as well as staffing concerns.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change of MRI mode","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Change of dose regimen (new protocol)","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Change of practice in the department","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Change of practice pattern. Green light laser","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Change of research focus","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change of staff","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Change of study population and chemotherapeutic regimen","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Change the sample size due to smaller variance than expected","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Change to investigator's research affiliation and other employment.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Changes & upgrades in informatic infrastructure of the web-based intervention.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Changes in practice","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Changes in treatment paradigm resulted in a lower than expected rate of accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Changes of SoC for third line therapy resulting in poor recruitment","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Choice of the principal investigator","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Clearly identifiable benefits 50% of patients included","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Clinical Hold","label_descriptions":["Invalid_Reason","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Clinical Hold pending additional data review and protocol amendment","label_descriptions":["Study_Design","Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Clinical Hold- product related issue","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Clinical Team decision to terminate the study after the results from Cohort 1 did not support\u00ca conducting Cohort 2.","label_descriptions":["Endpoint_Met","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Clinical partner left University,\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Clinicians were not offering the study to eligible potential subjects.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed due prolonged enrollment timelines","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed due to delay by GSK","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed due to futility with only 1 patient accrued","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed due to insufficient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed due to insufficient recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed due to lack of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed due to poor accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed due to slow accrual","label_descriptions":["Logistics_Resources","Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed due to slowing enrollment and negative results of a phase III trial using cabozantinib.","label_descriptions":["Insufficient_Enrollment","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed early due to poor accrual.","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed for lack of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed to Accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed to accrual in March 2009 for slow accrual.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closed, never started.\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Closure of Indiana University Health Proton Center in December 2014","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Closures due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"CoStar Stent IDE failed to meet primary endpoint","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Collaboration could not be established","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Collaborator no longer interested, short of funds\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Collected study data was not usable due to process miscommunications","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Combination of departure of Investigator from one site and slow recruitment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Comflicting interim data","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Commercial availability of Xenazine","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Commercial decision to discontinue the study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Commercial reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company Decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company business decision, IDE closed, no commercialization planned\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company closed May 1, 2019","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision has been taken in light of recent demands by certain national health authorities","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision not to pursue prior to submission","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision taken in light of demands by certain national health authorities","label_descriptions":["Business_Administrative","Regulatory"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision to discontinue the AVE1642 development program, not due to any safety or efficacy concerns\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision to discontinue the study, not due to any safety or efficacy concerns","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision to discontinue trial","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision to halt study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision to not fund further development of women's health new drug development programs.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision to withdraw product from the market and terminate development initiatives due to potential device failures.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company decision. Non-safety related","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company is closed","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company restructured and protocol restructured. Resubmitted with IDE approval under new company name-Exalenz","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company stopped production of study drug due to excessive toxicities, lack of efficacy","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company strategic decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company strategy","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company suspended development of product.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company terminated drug support","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Company went out of business","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Competing Departmental Studies","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Competing studies","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Competing study at site","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Competing study opened","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Competing study was started.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Compound is not expected to change the current treatment practice or fill significant clinical\u00ca need for patients in China over currently available EE agents.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Computers\/hardware for data collection\/storage are outdated and unserviceable.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Concerns about safety at the first interim analysis","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Concerns regarding neonatal data","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Concluded - Terminated by PI","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Consent form is being revised","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Consenting participants entered tenofovir\/emtricitabine oral prophylaxis trial","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Considered not necessary to continue with this trial; recommended dose was reached in other phase I trials","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Context of the Covid-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Contract Issues","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Contractual issues","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Coronary flow by echo Doppler was obtainable in about 50% of subjects. The study was stopped early because of insufficient sample size to achieve adequate power","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Coronavirus precautions, clinical research center closed","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Corporate decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Corporate decision to discontinue distribution of MJS Knee.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Corporate decision to reformulate the investigational product.","label_descriptions":["Business_Administrative","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Corporate re-prioritization","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Corporate reasons unrelated to safety and efficacy","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Corroboration of supporting in vitro data","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Costs of study procedures has changed and escalated and became prohibitive.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Could not enroll enough participants, and lost funding.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Could not enroll patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Could not find subject population","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Could not meet recruitment, technology advancement.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Could not recruit","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Could not recruit any more people.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Covid 19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Covid-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Covid-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Covid-19 pand\u00cc\u00a9mie","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Covid-19 resolution.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Created Extension study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Created Extension study - This study was no longer feasible","label_descriptions":["Study_Design","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Cubist has reached an agreement with the FDA that enrollment in the DAP-RENSE-08-05 study can\u00ca stop.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Current lack of medication support.","label_descriptions":["Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Currently on partial clinical hold due to COVID-19 policies.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Currently suspended due to COVID-19 policies","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Currently suspended due to COVID-19 policies.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Currently suspended due to Covid-19 policies.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Currently suspended due to covid-19 policies.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Curretly suspended due to Covid-19 policies.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMB","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMB felt continuing study will not yield any statistical significance.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMB recommendation for slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMB recommended termination due to lower survival to discharge in primary population and worse discharge CPC scores in the treatment arm than control arm.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMB recommended termination due to lower survival to discharge in primary population and \u00ca worse discharge CPC scores in the treatment arm than control arm.","label_descriptions":["Regulatory","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMB review at 50% recruitment, further recruitment unlikely to change result\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMB reviewed data of 1st 10 subjects; determined no safety concerns. Efficacy as a single agent in this patient population was unlikely. Voluntary Termination","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMB stopped the study based on conclusion of likely futility of treatment on the primary outcome.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMB stopped trial for futility","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMC acknowledged no safety concerns with the trial, recommending that the trial be terminated due to slow enrollment.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMC acknowledged no safety concerns with the trial, recommending that the trial be terminated\u00ca due to slow enrollment","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"DSMC recommendation based on safety data","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"DSPD focussing on Study 301 to confirm clinical profile before proceeding.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Data Monitoring Committee cited poor accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Data Monitoring Committee decision on 22nd August 2011 for safety issues","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Data Safety Monitoring Committee decision","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Data inconclusive.","label_descriptions":["Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Data presented at SABCS 2010 showing that dual blockade is superior to monotherapy","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Date of termination was Feb. 7, 2008. Reasons of termination were due to elevation of liver function tests and long elimination half-life of the compound.\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Decided to conduct study in adults first","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision made by B&L to cancel the study, no subjects enrolled.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision of the Sponsor, as the funding of the study was no longer guaranteed.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision of the Steering Committee. Recruitment more difficult and slower than expected.","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision of the investigator","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision to change trial design.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision to discontinue due to challenges of trial design and constraints on enrolling eligible\u00ca and consenting patients.","label_descriptions":["Study_Design","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision to modify the product under study as a result of feedback regarding subjective feeling during installation procedure. For more info, see brief summary.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision to obtain PK data at a later date","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision to stop study due to low recruitment.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision to terminate recruitment on this study was based on lack of efficacy observed to date","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Decision was taken by Wyeth Sr. Management to early terminate the 3100N7-210 study (terminate enrollment but complete follow-up).","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Definitive discontinuation according to safety monitoring of death from the 46th patient\u00ca onwards.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Delay in the R&D stage","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Delayed recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Delayed recruitment as compared to that expected","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Delayed start of the trial, both treatment options already have market authorizations, study \u00ca medication expired","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Delayed to review safety data","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Departure of the investigator coordinator into other country","label_descriptions":["Logistics_Resources","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Despite considerable efforts to boost recruitment during the final year of the study, no new\u00ca patients were enrolled.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Development of Current Formulation has Ceased","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Development of JNJ-64041757 in combination with nivolumab discontinued due to lack of clinical\u00ca benefit observed in the Phase 1b portion of the study","label_descriptions":["Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Development of XL999 was stopped due to cardiac toxicities in the subjects","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Development of tasquinimod in prostate cancer discontinued","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Development of this compound was discontinued.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Development program ended due to inability to pair with other cytidine analogs and higher risk\u00ca of hyperlipasemia when not used with 3TC\/FTC.","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Development program terminated.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Development project stopped","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Device superceded by next generation device. Enrollment stopped, long term follow up was completed in August of 2004.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Did not get approval","label_descriptions":["Ethical_Reason","Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Did not meet accrual goals.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Did not meet enrollment goals","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Did not meet predetermined primary endpoint","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Did not meet the criteria for continuation to second stage","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Did not reach enrollment goals","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Did not receive budget needed.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Did not recruit","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Did not support the planned development of DCCR in the new indication","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Did not want to enroll and proceed with this study concept.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Didn't receive IND exemption. PI withdrew rather than reapply to FDA. No patients enrolled.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficualty in recruiting patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficult enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficult getting subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficult of recruiting","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficult recruitment -","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficult to recruit participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulties in finding enough study participants.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulties in getting suitable applicators for biodegradable stents.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulties in logistics handling the very severe patients (travel, hospital stay, follow-up)","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulties in manufacturing the cell products essential to the study.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulties in recruiting enough subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulties in recruiting patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulties in recruitment - will require longer time to achieve sample size","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulties in the organisation","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulties of recruitment, lack of elligible patients\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulties with recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficultly in enrolling","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty enrolling eligible subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty enrolling patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty enrollment, no patients received treatment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty finding eligible participants and lack of funding.","label_descriptions":["Logistics_Resources","Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty finding eligible sites\/patients:current situation in health policy cause negative effects on existing\/planned contracts for integrated care programs","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty finding eligible sites\/patients; current situation in health policy cause negative effect on existing\/planned contracts for integrated care program","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty finding the required patient population","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty finding the required subject population","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty in accrual of study subjects, small numbers of potential subjects\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty in identifying subjects satisfying the inclusion criteria.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty in recruiting","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty in recruiting and maintenance of blinding necessary for the trial","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty in recruiting patients for the study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty in recruiting subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty in recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty in recruting patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty meeting patient accrual goals","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty obtaining enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty of participant enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty of realization of the study","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty recruiting","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty recruiting (early discharge scheme initiated)","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty recruiting eligible patients in timely fashion","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty recruiting subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty recruiting subjects to dosing cohort 5.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty to include patient","label_descriptions":["Logistics_Resources","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty to include patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty to keep children in randomly assigned groups.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty with accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Difficulty with enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Dificulties in the recruitment of patients.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Discontinuation of program","label_descriptions":["Business_Administrative","No_Context"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Discontinuation of the development","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Discontinued PB127 development program for business reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Discontinued cystitis study due to poor recruitment. To continue the trial under these\u00ca circumstances is considered non-viable.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Discontinued due to company's strategic reason","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Discontinued due to incomplete recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Discontinued due to non-enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Dissatisfactory enrollment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Dose levels were determined to be subtherapeutic","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Dose limiting tox is observed. Study put on full clinical hold.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Dose limiting toxicities on lowest dose level","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Dosing stopped","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Dr. Grose has left this practice, this study is terminated\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Dr. Holguin is relocating.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Dr. Jorizzo has decided to withdraw from this study due to the time it is taking to get the study started.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Dr. Milla has left University of Minnesota. The study is no longer being conducted at this site.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Dr. Vindas completed his fellowship + low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug (Aflibercept) no longuer available for the study","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug Manufacturer withdrew support for studies not in metastatic breast cancer","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug combination is no longer pursued","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug company decided to terminate all sponsored clinical studies involving rilotumumab.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug company withdrawal of support for investigational agent in this indication.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug development suspended","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug exposure of retaspimycin HCl was superior to IPI-493, Infinity will focus on Retaspimycin\u00ca HCL","label_descriptions":["Success","Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Drug related AEs observed upon repeat dosing that with longer treatment duration could become\u00ca worse. Required action on some biomarkers not observed.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug sold to Sanofi-Aventis who sold it to GSK; OBS no longer owns study and does not have data.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug supply issue - Contracts with New source Genzyme Canada are in negotiation","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug supply shortage. Study should reopen in February, 2008\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug supply unavailable.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug unavailable","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug was not sent","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug was pulled from the market.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug withdrawal","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drug withdrawn from market","label_descriptions":["Business_Administrative","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Drugs unavailable- study terminated 1\/2\/18","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Drugs unavailable:unable to make radioactive topotecan","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to COVID -19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to COVID -19, study is suspended to accrual only","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to COVID-19 and tissue resource not available at this time","label_descriptions":["Covid19","Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to COVID-19 outbreak, study is temporarily suspended.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to COVID-19 policies.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to COVID-19, effective 3\/19\/2020 recruitment is halted until further notice","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to COVID-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to FDA comments, indications for use were chnaged and a different population will be proposed shortly\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to Health Canada losartan recall, a new formulation being added to the protocol\/ temporary\u00ca suspension","label_descriptions":["Study_Design","Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to MOH request.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to PI's Study_Design with IRB requirements","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to Protocol AC-055B201 (MUSIC) not meeting it's primary end point","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to Sponsor's decision, only 12 patients were randomized & completed study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to Sponsor's financial reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to a lack of IP supply and then terminated because they were combined into one new study with the new IP formulation.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to a low recruitment rate since start of recruitment period.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to a single, unexpected serious event, the trial was stopped.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to a substantial response to placebo an interim analysis indicated the need for a larger than expected study population to achieve the level of significance","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to administrative reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to administrative reasons not related to efficacy or safety.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to an administrative reason","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to business considerations; not due to toxicities or adverse events.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to business decisions","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to celecoxib safety issues","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to changes in portofolio review","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to clinical trial supplies shortage","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to company decision to focus resources on a larger, controlled study in this patient population.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to company decision to focus resources on the finalisation of three ongoing studies in the region","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to concerns about potential liver safety (See Detailed Description)","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to continuing review","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to country-level restrictions regarding COVID19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to decrease in Avaulta mesh kit usage & inability to recruit study subjects.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to difficult enrollment, and investigator agreed to terminate this study.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to difficult patient enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to difficulty in patient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to difficulty with enrollment of subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to dose re-selection","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to drug unavailability","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to efficacy results of interim analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to emerging safety data","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to enrollment challenges resulting from changing treatment patterns in the use of\u00ca cetuximab, the study has been terminated. No patients remain on study.","label_descriptions":["Study_Design","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to ethical concerns regard to the results from the WHI study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to existing evidence eligible patients receive CRT treatment in first place","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to extreme toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to failure to control sufficient patients in the active arm, this study has now been closed.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to financial issues of Restora spacer company.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to funding issues.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to graft failure.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to high incidence of neurological complication in those with ilioinguinal block","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to inadequate recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to insufficient funds","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to insufficient patient inclusion the study has been stopped prematurely.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to internal reasons study was not performed.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to lack of availability of study participants to accommodate the study design","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to lack of coordinator coverage","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to lack of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to lack of funding","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to lack of funding and a primary co-investigator of the trial leaving the institution.","label_descriptions":["Business_Administrative","Logistics_Resources","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Due to lack of malaria patients in Zanzibar the study has been suspended.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to lack of recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to lack of recruitment and loss of the French principal investigator.","label_descriptions":["Insufficient_Enrollment","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Due to lack of sufficient efficacy.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to lack of supply of the investigational product.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to late study start, the possibility to enroll enough subjects dropped below the limit to\u00ca provide scientifically acceptable data, hence study was cancelled.","label_descriptions":["Insufficient_Enrollment","Insufficient_Data","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to limited pool of eligble WNV patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to low accrual","label_descriptions":["Logistics_Resources","Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to no patient enrollment this study was withdrawn\/closed","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to non-feasibility","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to numerous delays in study start-up process...","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to other projects priority","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to poor accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to poor accrual of the study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to poor compliance with study drug administration.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to poor enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to poor enrollment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to poor enrollment, this study was terminated.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to poor patient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to poor patient recruitment, a decision was made to terminate this trial.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to portfolio and logistical issues, this study will not be re-started at the present time. The study is not being terminated for safety reasons.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to portfolio\/business decisions by the sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to potential concerns about liver safety (See Detailed Description)","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to projected low enrollment, UroGen has decided not to move forward with the study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to recent findings relating MRI contrast to nephrogenic systemic fibrosis","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to recent strategic policy developments in the national vaccination program it is uncertain preadolescent girls will receive the HBV vaccin.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to regulatory\/compliance observations noted in a Data Safety Monitoring Board UCSD audit report & requirements by NIH\/Recombinant DNA Advisory Committee.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to reported toxicity of Celecoxib at high doses","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to results of conditional power analysis performed at the first interim analysis and due to observed spectrum of adverse events.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to safety concerns","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to safety; specifically a higher rate of deaths, including fatal infections, in the SGN33A\u00ca arm versus the control arm","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to slow accrual","label_descriptions":["Logistics_Resources","Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to slow accrual of patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to slow participant accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to slow recruitment and a delay in reaching the recruitment target.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to slow recruitment and a significant delay in reaching the recruitment target.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to slow, insufficient accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to specimen collection difficulties; this study has been terminated","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to strategic reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to strict inclusion and exclusion criteria no subjects were enrolled","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to strict measures of the government to contain the spread of COVID-19 outbreak, we follow","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to supply constraints & prioritization according to medical need (availability of\u00ca alternative rabies vaccines), Rabipur will no longer be supplied to China.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to technical issues relating to the Electronic diary data.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to termination of study D3801C00001, due to reports of turbid urine.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the COVID-19 pandemic, recruitment and screening visits have been suspended until","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the COVID-19 pandemic, recruitment and screening visits have been suspended until\u00ca further notice.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the COVID-19 pandemic, study has been temporarily halted and will resume in the future","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the COVID-19 pandemic, this study has temporarily suspended recruitment activities.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the COVID-19 pandemic, this study has temporarily suspended recruitment activities.\u00ca Other elements of the study are ongoing.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the achievement of minimum required sample size and new changes in local regulations.","label_descriptions":["Business_Administrative","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the arrival of DAAs replacing standard of care for genotype 1 patients the VIRID study \u00ca had to be terminated.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the current COVID-19 pandemic, the recruitment of new subjects is temporarily","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the current COVID-19 pandemic, the recruitment of new subjects is temporarily\u00ca discontinued. Ongoing, randomised patients are managed per Trial Protocol.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the high rate of morbidity and mortality","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the impact of COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the lack of enrolment and complexity of design, the QAX576A2103 study in asthma was terminated. No subjects have been dosed for this study.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the meta-analysis about CV adverse effects of rosiglitazone.","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the publication of significant literature in this area since commencement of the project which has now rendered the project unnecessary.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the recent meta-analysis about CV adverse effects.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the results of interim analysis at the time 44 patients were recruited.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the sale of Cardene IV, the sponsor has stopped enrollment and terminated the study. No safety issues were identified.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the slow rate of recruitment the study was stopped.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the uncertain regulatory landscape for erythropoiesis-stimulating agents in oncology indications.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to the uncertain regulatory landscape for erythropoiesis-stimulating agents in oncology \u00ca indications.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to toxicity of cyclophosphamide","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to unacceptable non-dose limiting toxicities, excessive treatment delays and limited clinical responses.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to unforeseen circumstances this study will not now start.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to unforseen recruiting difficulties, the study was closed.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to unmet accrual\/randomization goals","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Due to unstalbe cell sheet quality. We didn't use this tech on patients.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"During routine safety review of Studies U2970g and U2971g, the Data Monitoring Committee recommended that enrollment in this extension trial be terminated\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"During the study","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"During treatment session 3, a subject had a pattern of AEs of severe intensity, suggestive of brainstem toxicity\/encephalopathy during lidocaine\/saline infusion\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"ECOG will not proceed with activation","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"EMD Serono voluntarily decided to terminate this trial after observing increased MS disease activity in the atacicept treatment groups compared to placebo","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"EMD Serono voluntarily decided to terminate this trial after observing increased MS disease activity in trial 28063 ATAMS [Please refer to ATAMS]","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"EORTC trail showed TMZ & RT conferred significant survivial in this population","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Early Phase I study of [123I]MNI-340 did not evidence as marker of disease","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Early efficacy review by the Independent Data Monitoring Committee indicated it was unlikely to meet its primary efficacy endpoints","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Early stopping rule","label_descriptions":["Ethical_Reason","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Early termination due to efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Early termination due to loss of interest and low enrollment of patient","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Early termination of IDX21459 was due to integration of Merck's HCV antiviral pipeline has\u00ca resulted in revisions of the clinical development plan.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Effective August 13, 2004: Unanticipated high incidence of post-transplant lymphoproliferative\u00ca disorder","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Effects of aripiprazole was not obvious and showed adverse reaction obviously","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Efficacy in pre-trial subjects indicated that the intervention did not warrant further investigation","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Efficacy not evident in this population.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Efficacy rates did not show large enough differences between treatments","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Efficacy seen in the solid tumour patient population was not sufficient to continue research with AZD1152 monotherapy in solid tumors at that time.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Efficacy was not cleared at US study","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Efforts at recruitment have halted as recruitment was poor.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Elevation of ALT and AST in some patients.","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"End of Agreement between BMS and SGHL","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"End of recruitment period","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"End of research time, time-resources\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"End of study time and budget permission","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"End of the recruitment","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"End of the study","label_descriptions":["Endpoint_Met","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Ended prematurely - The trial never commenced.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Endpoint no longer deemed meaningful","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrolled requested number of patients and completed study. In analysis","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrolled subjects were unable to receive drug from dispensing pharmacy.","label_descriptions":["Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollement target could not be achieved, study will potentially be resumed\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment Suspended","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment and interactions\/interventions paused due to COVID-19. Expected to resume in the","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment and interactions\/interventions temporarily paused due to COVID-19 & will resume in","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment and interventions are temporarily paused due to COVID-19 and are expected to resume","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment and other trial activities have temporarily paused due to COVID-19 and are expected","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment and study activities are temporarily suspended due to COVID-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment and\/or interactions\/interventions temporarily paused due to COVID-19 and expected to","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment below goal.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment by invitation only","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment challenges due to changes in standards of care resulted in premature termination. No safety or efficacy events factored into this action.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment challenges prohibited study progression.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment closed","label_descriptions":["Insufficient_Enrollment","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment completed","label_descriptions":["Endpoint_Met","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment criteria met","label_descriptions":["Endpoint_Met","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment difficulties","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment discontinued after second cohort completed.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment discontinued based on mutually agreed upon decision by PI and funding sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment discontinued pending protocol modification considerations.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment failed","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment goals not met","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment goals unable to be reached.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment has been terminated due to a slow rate of enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment into acute phase therapy ended August 1st, 2008. Randomized continuation phase trial is slated to end in June 2009 and follow-up to end in June 2011.\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment into study was slower than expected.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment is paused due to COVID-19. This is not a suspension of IRB approval.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment is pending further analysis of the stability of exendin-(9-39) at higher\u00ca concentrations.","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment is suspended due to COVID-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment is temporarily paused due to COVID-19 and is expected to reopen in the future. This","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment is temporarily paused due to COVID-19 and is expected to reopen in the future. This\u00ca is not a suspension of IRB approval.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment is temporarily paused due to COVID-19; interactions\/interventions with current","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment not initiated for study.","label_descriptions":["Insufficient_Enrollment","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment of patients has halted prematurely and will not resume. No future patients will be enrolled or treated.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment on Hold (COVID-19)","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment on hold due to COVID-19 pandemic.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment rate was too slow.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment slower than expected","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment stopped prior to Phase 1b, change in strategic focus","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment stopped until further notice due to COVID-19 restrictions","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment suspended based upon interim analysis; subjects allowed to stay on study until disease progression.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment suspended due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment suspended due to COVID-19, pre-screening continues for future enrollment","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment suspended due to COVID-19, prescreening continues for future enrollment","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment suspended due to low drug exposure.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment suspended due to protocol amendment","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment suspended during the COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment target not reached","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment temporarily suspended to prepare grant; need IRB reapproval","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment temporarily suspended, while protocol is being revised\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment too difficult","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment was completed with insufficient sample size for publishable results","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment was difficult","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment was much slower than anticipated, leading to a decision to terminate the study\u00ca early for enrollment futility.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment was slow and we decided to refocus our efforts on other studies","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment was slower than anticipated.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment was stopped based on the Data Monitoring Committee's recommendation.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment was too low.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment was too slow","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment was too slow and principal investigator moved to another country","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Ethics Committee approval denied","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Ethics approval denied","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Evaluation of surgical technique","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Evident advantages of one treatment (seton) over the other (Tissucol Glue)","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Evolution of patient's care allows no more recruitment","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Evotec has indicated that this study was discontinued due to a clinical hold issued by the FDA","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Excess toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Executive committee determined to close study after interim analysis.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Exhausted personel after a long recruiting period","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Existing vessel analysis software could not be applied to breast MRI data.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Expected mortality rates in placebo and treatment groups lower than predicted","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Experience gained from this study is sufficient to design and facilitate the follow-on study","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Experience gained from this study is sufficient to design and facilitate the follow-on study.","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Experimental arm (induction + low dose tacrolimus) not effective.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Experimental results were unsatisfatory compared with control.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Expiration of current lot of MEDI-507, ongoing discussion about future source of MEDI-507\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Expired IRB approval","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Expired for lack of continuing review","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Exploratory study proactively terminated by Roche after slow enrollment due to concerns regarding the CV safety profile of TZDs in patients with symptomatic CHF","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Extreme toxicity in Phase I, study did not proceed to Phase II","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"F Funding Expiration","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"FDA Clinical Hold","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"FDA Clinical Hold as of 12\/21\/07 due to safety concerns","label_descriptions":["Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"FDA Hold May 2007","label_descriptions":["Business_Administrative","Regulatory"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"FDA agreed to early termination of the study due to difficulties enrolling patients.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"FDA concerns regarding Avandamet","label_descriptions":["Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"FDA drug recall on July 30, 2010","label_descriptions":["Study_Design","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"FDA has placed all trials involving Pacritinib on Full Clinical Hold","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Facet no longer has ownership of ularitide.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Fail of applying funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failed primary endpoint","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failed to enroll patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure of an inroducer sheath used in the technique specified by the study. posing a risk. No adverse outcome has occurred in a study patient.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure rate was 100% in one arm of the study (the intervention)","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure to Recruit in a Timely manner","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure to demonstrate a tolerable dose that had potential for efficacy.","label_descriptions":["Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure to include","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure to recruit","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure to recruit due to polypharmacy","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure to recruit enough patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure to recruit patients with membranous lupus nephritis not previously treated with azathioprine .","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure to recruit sufficient participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure to recruit sufficient participants.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Failure to secure adequate funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Feasibility and low enrollment","label_descriptions":["Study_Design","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Feasibility concerns due to changes in standard of care","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Feasibility issues, only 1 patient recruited.\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Felt not to show benefit over control per DMC and confirmed via futility analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Few subjects recruited, sponsor withdrew support.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Field Safety Notice related to potential ventricular oversensing associated to the PhD feature\u00ca on Paradym ICDs","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Final study report has been completed and submitted","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Financial Constraints","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Financial and administrative matters did not allow collaboration among centers.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Financial concerns with device manufacturer.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Financial constraints","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Financial difficulties","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Financing and re-organization","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"First subject over five years after the transplant. The second subject is not in compliance \u00ca with follow ups. We do not plan to enroll more subjects.","label_descriptions":["Study_Design","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"First two patients enrolled after trial reopened, developed grade III-IV acute GVHD and \u00ca subsequently passed away.","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"FlowMedica was purchased by AngioDynamics. Study will be re-started by AngioDynamics.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Follow up only","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Follow-up end in 1999","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Following Regulator inspection in 2009, study terminated as inadequate approvals were in place","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Following a pre-specified interim analysis and Data Monitoring Committee recommendation due to insufficient level of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Following a pre-specified interim analysis and Data Monitoring Committee recommendation due to\u00ca insufficient level of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Following an SAE, study was put on hold. After performing preclinical follow-up studies, volunteers were no longer available for continuation.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Following recommendation by SOLAR Study IDMC, Astellas closed enrollment in ASP8273 studies.","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Following the recall of Ionsys, the study has been stopped. Data analysis will be undertaken in accordance with the Analysis Plan.\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Following the termination of development and commercialization agreement for S-1 with Taiho Pharmaceutical","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"For Strategic Reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"For business reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"For financial and logistical reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"For safety reasons the recruitment was halted prematurely. Patients on the trial continute to \u00ca receive treatment and are being followed up as part the protocol.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Formulation issues.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"From Sept.\/08 to April\/09 only 30 subjects were recruited. It has proved extremely difficult to recruit subjects.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Full Clinical Hold","label_descriptions":["Business_Administrative","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funder withdrawn funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funders withdrew funding due to slow recruitment","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding Discontinued","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding Period Ended","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding agent withdrew funding","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding allocation to different clinical trials.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding and manpower for this study was unavailable, and completion within a reasonable\u00ca timeframe was not possible.","label_descriptions":["Business_Administrative","Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding and study drugs unavailable","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding associated with enrollment milestones was withdrawn by Sponsor.","label_descriptions":["Logistics_Resources","Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding completed","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding constraints","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding ended","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding ended for the study","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding expired","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding expired, low recruitment","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding expired, low recruitment\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding for continuation was not received.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding for the CALM-PD Cohort Study was terminated by sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding has been pulled","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding issue","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding issues","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding issues.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding limits exceeded prior to complete enrollment.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding nonavailability and principal investigator move","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding not available","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding not available, PI left institution","label_descriptions":["Business_Administrative","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Funding not available, study did not open to accrual and will not open in future","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding not available. Could not start this study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding not obtained","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding not received","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding problem.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding problem; trial abandoned.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding ran out","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding support withdrawn","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding term completed. Final subject accrual for part 3 of study is on hold.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding terminated","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding unavailable","label_descriptions":["Business_Administrative","Logistics_Resources","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding unavailable at this time for this particular study.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding was inadequate to continue; Companies requested closure.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding was never granted for this study. No participants were ever enrolled.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding was never received so no patients were enrolled.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding was not acquired","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding was not approved","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding was not recieved","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding was terminated","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding was unable to be secured for this study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding was unavailable to complete the study as originally planned.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding was withdrawn from Drug company","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding will not be provided for the drug","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding withdrawn","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding withdrawn due to low enrollment","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding withdrawn from study sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funding withdrawn; study closed due to lack of accrual.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funds for study ended September 30, 2008.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Funds for this project have been spent, and it is thereby terminated.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Further development of this compound with ipilimumab in the treatment of melanoma is no longer\u00ca being pursued.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Further evaluation determined it was not feasible to enroll the post-partum tubal ligation group at our facility","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Further evaluation of pharmacokinetic data in the target population is ongoing","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Further evaluation of phase I dosing","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Further recruitment into the study was ceased on 10th December 2009, not attributed to safety. All patients recruited in the study completed all study visits.\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Further recruitment terminated after CE mark attained; enclosed patients will be followed up \u00ca to 5 years","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Futility","label_descriptions":["No_Context","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Futility analysis failed to showed likelihoo of benefit of CoQ 2400 mg\/day.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Futility analysis undertaken, determined that study was underpowered.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Futility analysis undertaken, determined that study was underpowered.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Futility boundary at interim analysis not met","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Futility in enrollment as of May 31, 2011","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Futility reasons after Independent Data Monitoring Committee interim analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Future development of AZD1236 is currently under review by the project team and no new studies will be started until this review is completed.","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"GSK decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"GanLee cancelled study -FDA Draft Guidance: \"Clinical Immunogenicity Considerations for\u00ca Biosimilar & Interchangeable Insulin Products\" released 11\/25\/2019","label_descriptions":["Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"GeneSearch_\u008a\u0097 BLN Assay has been voluntarily withdrawn from the US market.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Given the number of toxicities seen and the difficulty with patient retention in the dose\u00ca escalation portion, the sponsor decided to close the trial.","label_descriptions":["Business_Administrative","Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Gm test became routinely available. We could not compare the two arms anymore.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Grant application was not funded","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Grant expired","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Greater differences between randomized patients than previously anticipated","label_descriptions":["Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Had been finished","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Halted by NICHD after recommendation by DSMC to stop for futility","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Halted prematurely due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Halted prematurely due to slow accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"HandyLab device determined to not work for the science","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"HandyLab device did not work for the science","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Health Canada Approval date reached, no extension applied for\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Hepatic Safety Signal Identified.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Hepatic safety signal identified.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Hiatus for administrative reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"High dose citrulline treatment throughout pregnancy in rats may lead to elevated blood pressure in the offspring.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"High dropout, problems recruiting, and smaller than expected decline in FEV1.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"High incidence of TTP, poor recrual","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"High number of screen failures-could not find qualified subjects in timely manner","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Higher drop out than expected. Lower Statistical Power.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Higher hemorrhage rates of Abciximab in ABESST II trial","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Higher incidence of hospitalization for congestive heart failure in pioglitazone-treated subjects compared to glyburide treated subjects.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Higher incidence of hospitalization for congestive heart failure in pioglitazone-treated \u00ca subjects compared to glyburide treated subjects.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Higher than expected rate of acute rejection","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Hurricane caused closure of hospital with PI not associated with Shriners Hospital for \u00ca children","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"I am relocating to Johns Hopkins Medical Center","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"IDE not submitted","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IDMC recommendation","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IMP expired prior to completion of recruitment","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IMP supply","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IND application withdrawn","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IND exemption pending","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"INHERENT MODIFICATIONS NEEDED BEFORE PROCEEDING","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB Closure","label_descriptions":["Ethical_Reason","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB Study Closure","label_descriptions":["Business_Administrative","Regulatory"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB approval expired","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB approval has lapsed.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB has requested additional information regarding IDE","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB is requesting changes to the protocol","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB needs updated","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB process never completed.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB recruitment suspension due to COVID-19 related research restrictions.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB request","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"IRB study closure by investigator due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"ITF2357 (Givinostat) was well tollerated but had limited activity against refractory\/relapsed HL","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Identical study Biomed 777-CLP-029 did not meet superiority endpoint","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Illness of PI forced termination.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Implantation rate significantly lower in treatment group than Controls.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Impossibility to accomplish the sample size in assigned time.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"In 14 participants who had LP, very low level viremia was found in only 1","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In 2013 the FDA put a temporary hold on the trial and the Phase II portion of this study was\u00ca cancelled.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In a Phase II study in HIV-infected patients there were a number of seizures, although exact\u00ca causality could not be assessed phase 1 activity was terminated.","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In accordance with protocol's predefined criteria and Data Monitoring Committee recommendation due to insufficient level of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In light of the cessation of non-essential clinical activities at CPU due to the COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In light of the company's current financial position we have indefinately suspended the Rheo-AMD trial.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In most sites had difficult to recruitting subjects.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In order to join forces with another study already running which aims to answer the same question.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In process of renewing IND for AMP","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In response to COVID-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In the Netherlands we wanted to add pilimumab to nivolumab. This resulted in a very long METC\u00ca procedure which resulted in a to slow inclusion rate.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In the intermediate analysis, no effect could be shown, not even a tendency.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"In the process of transferring IRB to PI's current institution.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Inability meet enrollment in study population.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to accrue additional sites and enroll an adequate number of subjects.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to attain sufficient numbers of subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to enroll subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to enroll subjects.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to obtain grant funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to perform the study at present time.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to reach statistical significance toward primary endpoint","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to recruit","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to recruit and adequate number of participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to recruit eligible subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to recruit in time a sufficient number of patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to recruit required number of subjects.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to recruit required sample size.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to recruit sufficient number of patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inability to reliably measure plasma oxytocin levels during third stage labour, regardless of\u00ca administration method (intramuscular or inhaled).","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate Enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate accrual rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate accrural rates","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate eligible subjects to expect sufficient numbers to analyse outcomes.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate enrollement","label_descriptions":["Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate funding to support this fellow-in-training initiated study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate number of eligible patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate number of records screened; primary investigator left institution.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate patient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate rate of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate recruitment to meet completion date","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate retention of GHD adults to maintain power to study the effect of GH on fibrinolysis. A comparison between GHD adults and controls was completed.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inadequate toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Incidence of GI Perforation","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Incidence of abnormalities of liver function tests is higher than expected in this population.","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inclusion rate too low due to a lack of eligible patients and difficulties obtaining informed consent.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inclusion, treatments and follow-up are finished\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inclusion-rate does not seem feasible anymore to obtain te required number of patients before the end of the trial.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Inclusion\/Exclusion criteria was too stringent to enroll patients at this site.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Incomplete data","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Incorporating the recommendations of the NIH-formed DSMB in the study procedures would make the project budget over the limit for this funding mechanism.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Increased use of commercial product; less eligible patients & poor enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Incyte has suspended development of the compound.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Independent steering committee has stopped the trial based on results of a prespecified, blinded interim analysis. It was not stopped due to safety concerns.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Industry Funding Withdrawn","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Industry support and funding not forthcoming","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Infectious Disease Outbreak: COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Initial PI Dr. Marentis left the University of Michigan hospital","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Initial PI left, study not continued","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Institution decided on starting a new protocol of sedation, with another methods and that\u00e5\u00c0s \u00ca why this study has not started.","label_descriptions":["Study_Design","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Institution in Canada is conducting a similar clinical trial with potential of validating use.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient # subjects available for 2nd group; evaluating alternate study site","label_descriptions":["Insufficient_Enrollment","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Insufficient Accrual","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient Data Collected","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient Enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient Funds and Inadequate Subject Recruitment","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient accrual of population likely to benefit; progression in 6 patients","label_descriptions":["Insufficient_Enrollment","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient dose for MRI scanning","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient enrollment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient enrollment to justify keeping open.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient evidence of the clinical effectiveness of cangrelor","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient financial support to continue; lack of efficacy","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient findings for data analysis","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient funding to complete with low enrollment rate","label_descriptions":["Logistics_Resources","Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient funds","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient funds available","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient interest and recruitment - study ended prematurely by investigators","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient number of baseline eligible patient","label_descriptions":["Study_Design","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient number of inclusion","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient participants.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient patient enrolled","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient patient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient patient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient patients who met inclusion criteria","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient rate of volunteer accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient recruitment in a reasonable time + expiration of study medication","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient recruitment of study patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient recruitment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient recruitment, funding terminated from sponsor","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient recruitment.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient resources necessary for completion.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient response rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient study participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient subject accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient subject availability\/findings for data analysis","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient subject enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insufficient subject recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insuficient clinical activity.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Insulin-HF study was prematurely ended due principally to low recruitment rate.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Intended length of study ended","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Intepirdine did't meet primary efficacy endpoints in lead-in study RVT-101-3001","label_descriptions":["Another_Study","Negative"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim Analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim Analysis and review by Data Safety Monitoring Board","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim Analysis ongoing","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim Analysis result indicated the study will not show a significant benefit of the study medication on the primary endpoint.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim Analysis: Optimization of study design required.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analyses showed statistically and clinically significant results.","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Interim analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis has shown that the objectives of this study can not be reached","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis indicated that sample size of study patients had to be highly increased to obtain significant outcomes.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis of Primary Endpoint completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis of data failed to meet primary endpoint.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis of the present study showed a significant decrease in mortality rate (p= 0.04) as well as in the number of days at the ICU p=0.0002.","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis results did not meet criteria for second stage of trial","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis results revealed substantial increase of patient number, with unfeasible\u00ca study prolongation.","label_descriptions":["Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis showed a significant reduction in the pain scores","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Interim analysis showed efficacy less than 2.5%.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis showed greater variablility in NT-proBNP findings than anticipated.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis showed inadequate efficacy of bifeprunox","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis showed more LCFs in one of the treatment arms","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis showed no difference in outcome between treatment groups.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis showed no drug efficacy.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis showed significant results, thus study was stopped\"","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis suggested a trend favoring ecallantide; observed response rate to placebo was\u00ca substantially higher than described in medical literature.","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Interim analysis, infliximab did not reduce number of first relapses in GCA or cumulative glucocorticosteroid dosage\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim analysis-DSMB stated good safety profile but lack of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim data analysis showed no effect between treatment groups","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim data indicated that subjects exhibited no meaningful allergic disease during the first ragweed season, making it impossible to measure treatment effect.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim efficacy analysis indicated it would be futile to continue study.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim results of another trial showed inferior activity of treatment","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim review indicated that the dose selected was too high for diabetics","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Interim safety analysis","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Internal Business Decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Internal Study team decision not to proceed.","label_descriptions":["Business_Administrative","No_Context"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Internal business decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Internal problems","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Interruption of business relations between Study Sponsor and Device Manufacturer","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Intervention did not appear to be effective in most enrolled patients.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Intervention\/interactions are temporarily paused due to COVID-19 and are expected to resume.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigation of adverse events for a study in Germany using erythropoetin","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigational product unavailable due to manufacturing issues","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigations on a Suspected Unexpected Serious Adverse Reaction (SUSAR)","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigations on a Suspected Unexpected Serious Adverse Reaction (SUSAR) in another trial (Phase II Multiple Myeloma trial EMR63325-008)","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigator Resigned","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator Retired.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator closed study and left VAMC.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator decided it was not feasible to conduct this study","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigator decided to withdraw participation in the study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigator initiated hold due to animal toxicity results in another study; then changed study design so it no longer fit the description of this study.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigator is leaving Dartmouth","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator left UTHSC-Houston","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator left institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator left institution. 7 patients accrued and there is insufficient data to analyze.","label_descriptions":["Insufficient_Data","Insufficient_Enrollment","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator left the institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator left the institution, another PI has not been named.\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator left the site. Site closed.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator letter from drug manufacturer stating animal studies showed increased risk of \u00ca cancer which was an unknown adverse event","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigator moved to another institution.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator moved to new institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator no longer at Cleveland Clinic","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Investigator's decision:Did not open to enrollment","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigators have withdrawn study due to poor subject compliance.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Investigators no longer interested in activating study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Issue of priority of resources","label_descriptions":["Logistics_Resources","Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Issues w\/recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Issues with CTM stability.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Issues with data collection tool","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"It is too difficult to recruit suitable patients.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"It was decided on 9\/21\/2016 to terminate this study early because LogPad devices the patients\u00ca used to record their injection data was flawed","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"It was decided that data from this study are no longer required and therefore it is not\u00ca necessary to expose patients to the study medication","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"It was decided to close the study to further enrollment based on data from a similar study using ABT-751 and Pemetrexed that did not show efficacy.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"It was decided to use a different protocol with a different radioligand","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"It was found that the devices were not suitable for the application.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"It was not possible to perform 2 MRI studies in each patient due to practical problems. The study was not suspended due to safety issues.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"It was not possible to recruit enough patients with obstructive sleep apnea.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"It was not possible to recruit new patients anymore","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"It was stopped due to a lack of recruitment after 48 patients included","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"It was very difficult to enroll patients in this study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"JNJ-54416076 program has been stopped for strategic business reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Judicial liquidation of the society providing dietary supplementation.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Just Terminated for the end of the pandemia","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"LIFE Bronchoscopy equipment no longer functioning and cannot be repaired.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"LOGISTIC DIFFICULTIES","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of Accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of Drug Supply","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of Efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of Efficacy.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of Enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of Funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of Funding\/ Resident in charge graduated","label_descriptions":["Business_Administrative","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Lack of Response","label_descriptions":["No_Context","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of Subject Recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of Vaccine Supplies","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of accrual","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of accrual and funding is about to expire.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of accrual, study closed.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of adherence and huge loss of follow up.","label_descriptions":["Study_Design","No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of available clinical drug supply","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of available participants that meet criteria","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of budget","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of drug supply","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of drug supply for doxercalciferol for this study","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of efficacy and funding to continue investigation","label_descriptions":["Business_Administrative","Negative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of efficacy demonstrated in study ICA-17043-10","label_descriptions":["Another_Study","Negative"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of efficacy following an interim analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of efficacy in European Phase 2 study","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of efficacy in Multiple myeloma","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of efficacy.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of efficacy\/Manufacturer stopping drug development","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of eligible participants to enrol","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of enrollment","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of enrollment of suitable candidates","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of enrollment to the trial.Very difficult popultion to recruit.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of enrolment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of equipoise","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of feasibility due to low recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of financial support","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of financial support. Study criteria severly limited enrollment.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of funding","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of funding prevented the recruitment of 1000 HIV Patients all over India","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of funding to support clinical trial","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of funds","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of funds; FDA approved a topical form of diclofenac during study, no need to continue \u00ca study of pharmacy-compounded drug.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of improved efficacy compared to historical controls, competing studies","label_descriptions":["Another_Study","Negative"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of patient accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of patient compliance","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of patient recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of patients compatible with the protocol__s criteria","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of patients to enroll.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of patients with a condition of interest that resulted in failure to recruit","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of patients, lack of funding for analysis\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of personnel","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of personnel to continue","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of recruitment due to changed therapy options","label_descriptions":["Study_Design","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of recruitment\/participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of recrutment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of response activity in the setting of an unacceptable toxicity profile","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of staff and funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of study enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of study funding & resources","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of study population","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of study subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of subject enrollment over the past two years.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of subject population for PI","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of subject recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of sufficient funds","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of support from pharmaceutical collaborator.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of the subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lack of volunteers who would consent to participate and lack of funding","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lapatinib-topotecan arm enrollment closed early per protocol amendment 2. Then enrollment into remaining arm terminated due to operational issues.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Large sample size and change in Orthopaedic practice to use of CCPM in conjunction with Clinical Monitoring rendered project less timely.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Last patient left the study after the last visit","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Last subject enrolled experienced bradycardia; study was terminated by Sponsor.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Last subject out","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lead was recalled and manufacturing halted","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Leaving of the person responsible for the data collection","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Limitation of funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Limited beta-blocker naive participants among newly diagnosed heart failure participants, which\u00ca led barrier to the recruitments.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Limited budget to continue this study","label_descriptions":["Logistics_Resources","Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Limited number of subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Limited numbers of patients qualified for trial","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Limited regulatory value to uncontrolled trials. No safety\/efficacy concerns.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Limited resources","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Local IRB decision due to poor accrual","label_descriptions":["Insufficient_Enrollment","Study_Design","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Local pharmacy unwilling to comply with study protocol","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Logistic problems with adequately timely organ collection and transport","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Logistic reasons (insufficient funding, technical problems with MEMS)","label_descriptions":["Logistics_Resources","Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Logistical difficulties running the study","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Logistical reasons","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Logistics failure and staff\/scanner shortage","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Loss of Research Data","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Loss of funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Loss of funding from sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Loss of study staff","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Lost funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lost funding; Shriner Burn Hosp has revoked access to study records. No updates or results can\u00ca be submitted","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low Accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low Accrual, Funding","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low Accrual, Funding\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low Accural","label_descriptions":["Logistics_Resources","Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low Enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low Recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accrual and loss of funding","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accrual and loss of funding.","label_descriptions":["Business_Administrative","Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accrual not allowing site to meeting statistical endpoints","label_descriptions":["Logistics_Resources","Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accrual rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accrual rate.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accrual, no adverse events.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accrual, study terminated.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accruals","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low accrural","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low acrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low cure rate in the study (fluconazole) group","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low enroll rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low enrollment due to the stringent enrollment criteria. Unable to answer study questions","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low enrollment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low enrollment rates","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low feasibility","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low inclusion rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low levels of recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low likelihood of identifying a statistically significant treatment effect.","label_descriptions":["Study_Design","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Low overall response rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low participant accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low participant accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low patient accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low patient enrollment; toxicities","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low probability of positive outcome","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low rate of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low rate of patient recruitment; low likelihood of achieving the sample size in a reasonable time frame. No safety concerns.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low rate of subject accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low recruitement rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low recruitment due to change in standard of care","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Low recruitment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low recruitment rate due to treatment regimen change","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Low recruitment rate. In our center, open radical prostatectomies have been almost completely\u00ca replaced by robotic prostatectomies.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Low recruitment rate. with the final sample primary endpoint could be assessed.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low recruitment status","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low response","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low study accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low study enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low study enrollment; re-evaluating study protocol and study selection criteria.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Low study participant enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low\/no enrollment. No subjects were enrolled over the past year.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Low\/slow accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lower than anticipated recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lucentis, a treatment superior to PDT, has become available i Sweden.","label_descriptions":["Another_Study","Negative"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Lucentis, a treatment superior to PDT, has become available i Sweden.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"MI-CP177 study closed per sponsor decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"MTD determined","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Main objective of study was met. Further recruitment was difficult.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Main reason: negative echo in the literature after the first publications.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Major amendments in progress","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Major difficulties recruiting participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Major planned study protocol modifications","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Major side-effects","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Making amendments to the study","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Malaria prev. fell in the study area, so we cannot evaluate the primary endpoint\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Management Decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Management decision not to conduct an additional efficacy study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Manufacturer changed device so no study will be done; ie it was never started","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Manufacturer stopped drug development","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Manufacturing change in one of the two lipid emulsion products being studied.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Manufacturing stopped","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Market dynamics including other technologies made the project not viable.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"May continue recruiting only if required by journal reviewers","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Medical Monitor action due to lack of compliance with audit.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Medication expired","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Medtronic acquisition of Restore Medical, business decision\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Melagatran\/ximelagatran was withdrawn from the market and clinical development in February 2006 in the interest of patient safety.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Melagatran\/ximelagatran was withdrawn from the market and clinical development in February \u00ca 2006 in the interest of patient safety.","label_descriptions":["Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Merged with the study NCT00307268","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Met criteria for study futility at interim analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Missed endpoint of meaningful clinical benefit, compared to prednisolone 2.7mg","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Missing evidence of the effectiveness of the study medication","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Modifications will be necessary before full IRB approval will be secured.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Modified dose schedule presented no advantage over previously studied schedule","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Molecule Development was Terminated","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"More cases of Febrile Neutropenia were observed in experimental group compared to standard treatment.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"More progressive stroke in one arm","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"More than 2 of 6 patients treated experienced dose limiting toxicities.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Most patients were unable to perform the test being used to measure lung function, thus it became clear the study would not yield clinically meaningful data\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Most pts requested to be treated with versed. It was difficult to randomize pts.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Moved study to USA","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Multiparas study terminated due to poor recruitment. Randomization revealed only after decision recorded on clinicaltrials.gov","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Music therapist left position.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Mutual decision by site and sponsor because of difficulty recruiting Patients.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Myriad has discontinued the development of Flurizan.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"NCI not moving forward with study execution.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"NIH grant ended.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"NINDS DSMB recommended trial be terminated for futility after reviewing an interim analysis of 84 subjects.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"NO available budget and difficulty in recruiting","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"NOT A CLINICAL TRIAL","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"NYU 03-67 reached accrual prior to this study opening.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Need amendments in application process and require IBD number from FDA","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Need for re-formulation","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Need funding and scientific collaborator","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Need to review design","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Needed PET facility closed","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Negative data from another trial led to termination of this trial by sponsor.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Negative efficacy results of the MAESTRO-01 study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Negative efficacy results of the MAESTRO-01 trial","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Negative feasibility assessment of recruiting the planned number of subjects within the study timelines","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Negative pharmacodynamics due to lack of Interleukin-13 signature in biomarker data from Part \u00ca I of the study.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Negative sorafenib results from ESCAPE trial and safety concerns of regimen","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Negativity of the first results of in vivo binding of 18F-PBR06","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Negotiations in progress regarding payment for drug.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Nephrotoxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Neurogen acquired by Ligand Pharmaceuticals - no further support for study. No safety concerns identified.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Neurogen acquired by Ligand Pharmaceuticals - no further support for the study. No safety concerns identified.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Never received final IRB approval for amendments, so never opened officially\"","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New clinical finding with Celebrex and cardiac concerns.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New compounds available in the indication (nivolumab\/pembrolizumab), toxicity of ipilimumab","label_descriptions":["Safety_Sideeffects","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New data makes this trial unethical","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New departmental administration, loss of key study faculty","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"New enrollment has been suspended, currently following previously enrolled participants\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New enrollment is temporarily suspended due to COVID19 restrictions","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New evidence and trouble recruiting","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New funding sources being sought","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New information on IMP affected the cost\/benefit ratio","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New information suggested a more effective treatment protocol.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New medications with improved response released, nonaccrual","label_descriptions":["Insufficient_Enrollment","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New research priorities","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New studies are being offered","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New study planned.","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New study with lenalidomide pending","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"New study written","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Newer technologies available; poor accrual to study.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Newly identified safety concerns have changed the risk and benefit considerations","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Nitric Oxide analyzer not functioning properly","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No Accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No IRB","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No Patients enrolled, business objectives have changed\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No Patients enrolled; sponsor not providing devices anymore","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No Resources - No Personnel","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No accrual - closed by PRMC","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No accrual due to rarity of disease.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No additional funding is available to continue this pilot study at this time.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No adequate recruitment","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"No agreement between investigator and sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No clinical investigator present","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No clinical significant","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No continued funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No diagnosis of visceral lesion was placed on 18 included patients. The study is thus stopped prematurely for ethical reasons.","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No difference found between two groups in a preliminary analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No difference in 28 day survival among treatment groups (futility). Data analyses showed earlier, but not higher, mortality in the hypertonic saline arms.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No difference in protein excretion at 6&12 months. No safety issues.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No documentation with MHRA to support clinical trial of a medicinal product.","label_descriptions":["Business_Administrative","Regulatory"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No efficacy (interim.analysis)","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No eligible candidates in 2 years of recruiting","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No eligible patient.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No eligible patients were enrolled","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No eligible patients were found, the study stopped without including any patients\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No eligible patients were identified so the study was terminated.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No enrolement","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No enrollment because of war in the study country.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No enrollment in past year, lack of interest\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No enrollment occurred. Subjects will be enrolled under a new protocol.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"No epidemic of Men C in 2019","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No financing possible","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No focus on this topic","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No funding","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No funding and data was not appropriate to consider continuing.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No funding available.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No funding for this study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No funding was received, no subjects were enrolled","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No fundings","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No further local interest in pursuing the study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No inclusions.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No longer acruing data for this study.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No longer enrolling patients, not enough enrollment\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No longer recruiting: participants are no longer being recruited or enrolled","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No longer relevant for investigation","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No longer sponsor of trial","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No longer viable","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No medication","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No more funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No objective responses observed following completion of Phase 1 dose-escalation","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No participant enrolled","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No participant recruited","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No participants enrolled","label_descriptions":["Insufficient_Enrollment","Study_Design","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"No participants enrolled, study terminated.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No participants enrolled.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No participants recruited, study discontinued.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No participants satisfied eligibility criteria and were enrolled into the study since July 2008.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No paticipants enrolled","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patient completed protocol","label_descriptions":["Insufficient_Data","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patient has been included in 9 months because of strict incl\/excl criteria","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients completed","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients could be recruited and randomized due to other center offering backdoor for treatment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients dosed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients enrolled after three years","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients enrolled and funding has been withdrawn.","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients enrolled during 2 years","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients enrolled. Study did not start.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients enrolled; study terminated.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients ever enrolled","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients had been accrued.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients met eligibility criteria. The study has been closed.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients recruited","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients recruited into study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients registered; study terminated.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients were enrolled because the company that pledged the drug does not yet have it\u00ca available.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients were enrolled in the study.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients were enrolled on the study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients were enrolled.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients were enrolled. Study terminated for portfolio reasons.","label_descriptions":["Business_Administrative","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients were recruited. Treatment drug expired.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No patients were treated due to enrollment challenges.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No recommended Phase II dose was determined.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"No recruited patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No recruitment on time","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No recruitment was achievable","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No resources available","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No response seen in patients","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No responses, study terminated early.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No safety concerns, the study was terminated due to slow enrollment. All enrolled patients will be followed per protocol.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No safety signals were noted. The study completed the main phase, additional potential study cohorts not required.\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No safety signals were noted. The study completed the main phase, additional potential study \u00ca cohorts not required.","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"No safety signals were noted. The study was stopped because it was no longer consistent with the company's scientific and strategic focus.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No safety signals were noted. The study was stopped because it was no longer consistent with\u00ca the company's scientific and strategic focus.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No satisfactory acrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No study drug available. Same concept with new study drug will be explored in M19TGA study","label_descriptions":["Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"No study funding available.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No study population in Mexico (H1N1). Study withdrawn from IRB consideration.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"No study recruitment due to time constraints and lack of support.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subject accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subject enrolled in nearly 2 years","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subject meeting criteria","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subjects enrolled","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subjects enrolled and PI went to another facility","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subjects enrolled, bio equivalence study, canceled before active.","label_descriptions":["Insufficient_Enrollment","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subjects enrolled. Funding withdrawn by sponsor.","label_descriptions":["Business_Administrative","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"No subjects enrolled. Study was canceled before active","label_descriptions":["Insufficient_Enrollment","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subjects recruited","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subjects were enrolled in this study. Funding ran out.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subjects were entered. The study group changed from patients to a healthy volunteers. A healthy-volunteer study is being planned to replace 213.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No subjects were ever enrolled. This study was closed at the IRB.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"No sufficient increase in plasma osmolarity by galactose (one patient included)","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Non significative preliminary data","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Non-compliance issues","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Non-favorable risk\/benefit profile with studied dosing regimen","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Non-protocol feasibility","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Non-safety related business decision to combine special population protocols","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Non-treatment trials suspended due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not Stated","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not able to recruit the estimated number of patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not able to recruit the number required and due to financial difficulty to pay for intralipids","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not adequate enrollment (sample size not possible to reach)","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not approved by CMS","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not approved by sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not developing product","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not enough enrollees to obtain a valid conclusion","label_descriptions":["Insufficient_Enrollment","Insufficient_Data","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Not enough enrollement","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not enough patients\/ ethical concerns","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not enough recources.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not enough recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not enough recruitment during the proposed period.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not finding patients for including","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not funded","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not funded Administrative formalities not completed","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not funded at this time.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not going to be conducted","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not moving forward with program.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not reached the statistical hypothesis at the interim analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not reaching recruitment and endpoint goals","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Not to expose the patients to subtherapeutic dose","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Notification from sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Novartis decided not to pursue further development of buparlisib program (assessment of\u00ca moderate PFS benefit with know, but manageable, buparlisib profile).","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Novartis decided to stop the marketing of BEZ235","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Novartis decided to terminate based on strategic and administrative reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Novartis ended all studies regarding Aliskiren.","label_descriptions":["Business_Administrative","Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Novartis terminated funding","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Novartis terminated this study due to internal, strategic decisions.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Numbe of eligible patients has been decreased over time.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Number included has been reached","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Number of patients willing to participate in the study too low","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"OBI business decision not to complete any additional research in HIV.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"OHSU IRB closed study to further enrollment 2\/17\/2006","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"ORD-Funded Studies due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Objectives of study could not be met within a reasonable timeframe.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Observation of low incidence of asymptomatic, transiently elevated liver enzymes in a subset of\u00ca study subjects","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Observed lower cure rates and higher mortality rates in one of the treatment groups.","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Occurrence of severe respiratory depression in the remifentanil group.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"On 25April2014, study was terminated before any dosing due to an AE of safety concern that\u00ca occurred in protocol B1731003 with the same drug.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"On February 28, 2019, Capricor ceased ongoing follow-up activities and terminated the ALLSTAR\u00ca trial to focus resourcing on its active CAP-1002 program, HOPE-2.","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"On Hold","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"On Hold due to COVID-19 outbreak","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"On hold due to COVID-19 outbreak","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"On hold due to lack of CTM supply","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"On of the liners has been taken from the market","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"On the basis of published results of SMART study, it has been observed that the results are worse in patients who have interrupted their treatments.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"One of the both Funder partners decided to stop the study before the initiation : thus no\u00ca product provided and no funding to realize the study","label_descriptions":["Business_Administrative","Logistics_Resources","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"One of the instruments in the study was withdrawn from the market before the calculated number of persons were included.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"One of the principal investigators has moved to a different institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"One participant enrolled, study terminated .\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Only 1 patient recruited and deemed ineligible.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Only apx 1\/3 of enrolled subjects (signed consent) participated. Futility analysis to show primary endpoint","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Only one patient included as per Feb. 4, 2008.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Only recruitment temporarily paused due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Only recruitment temporarily paused due to COVID-19 and safety measure","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Only recruitment temporarily paused due to COVID-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Only recruitment temporarily paused due to Covid-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Open label study part reduced from n=10 to n=6 because of insufficient number of patients\u00ca under antiaggregation.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Optimization of protocol","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Organizational reasons at sites: low recruitment","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Original PI left the institution, and lack of funding.","label_descriptions":["Business_Administrative","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Original investigator left the NIH and the primary outcome was not reached","label_descriptions":["Study_Staff_Moved","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Original study did not progress to Phase II.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Original study product (VSL #3) became unavailable; change in study Collaborator and product","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Other - COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Other - Higher than expected incidence of hearing loss","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Other - Participant safety due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Other - Safety during COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Other authors showed the same metabolic effect may be obtained when BMMC are delivered peripherally, with lower risk and cost than through hepatic artery.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Other stimulation target (slMFB) more efficacious, unethical to continue with Nucleus Accumbens","label_descriptions":["Study_Design","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Our PI left our institutions as we could not longer continue.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Our fellow completed the program before we were able to start the study","label_descriptions":["Study_Staff_Moved","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Our funding is quite limited and we need to determine if we have enough funds to continue.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Overall profile of the compound does not offer significant clinical advantage to patients over currently available lipid lowering agents","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Overall profile of the compound does not offer significant clinical advantage to patients over \u00ca currently available lipid lowering agents","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"P.I decided to prematurely end this study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"P.I. left the institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI Decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI Left institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI change in institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI changed institutions","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI decided to close study due to slow accrual.","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI decided to terminate the study at this time","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI decided to use another product","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"PI decision","label_descriptions":["Business_Administrative","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI has left institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI has left the study institution.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI health issues","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI is no longer at this institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI is relocating geographically and will not be able to follow subjects to study completion.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI leaving institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left Institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left JHU","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left NIH","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left NIH. No subjects enrolled.","label_descriptions":["Study_Staff_Moved","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left U of C","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left UAB; protocol administratively terminated by UAB IRB.","label_descriptions":["Study_Staff_Moved","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left institute and contacted IRB to close study.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left institution and terminated study","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left institution, end of funding, clinic relocation, recruitment issues","label_descriptions":["Business_Administrative","Insufficient_Enrollment","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left institution, study did not continue, funding stopped\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI left site","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left the VA.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left the institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left the institution before all data analysis was completed","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left the institution.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left the university","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left university","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI left university. Did not start study","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI move","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI moved from Hadassah","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI moved to a different institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI moving to Southern Illinois University to start new protocol","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI moving to another institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI no longer employed at Institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI passed away","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI relocated","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI relocated to another institution.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI request","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI resigned","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI resigned.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI returned to India","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI separated employment from the university.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI stepping down due to health issues","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI temporarily assigned duties as trauma physician in addition to his full time clinical and surgical duties.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"PI terminating study due to personal reasons.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI turned down funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI unable to secure funding for the project so study was not pursued.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PI wanted to discontinue study.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PK portion will be included in a future protocol","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PK results demonstrate low and variable plasma concentrations so that achieving therapeutic \u00ca concentrations is unlikely.","label_descriptions":["Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"PK results demonstrated no systemic absorption","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"PPFA desired additional interim analysis which would have significantly impacted the sample size and integrity of the study","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Part A reached a predefined stopping criteria. Relevant doses for part B could not be established based on A and subsequently study was stopped.","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Part A, the dose escalation and primary objective of the study, was completed. Part B, the\u00ca dose expansion, was not conducted due to a business decision.","label_descriptions":["Business_Administrative","Endpoint_Met"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Part B of the study was terminated early due to a lack of enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Participant safety during COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Participants are no longer being examined. The results are published 2016 Anticancer Research\u00ca 36: 6431-6438","label_descriptions":["Success","Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Patient compliance was low.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Patient population not available","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Patient recruitment was not sufficient to achieve the needed patient numbers.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Patient safety - Unacceptable toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Patient safety during COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Patient target could not be reached within the planned timeframe.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Patients did not respond to therapy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Patients not meeting inclusion criteria, therefore recruitment rate low, terminated due to the lack of feasibility to complete the study in a timely manner.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Patients would not take product","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Patients' enrollment was not sufficient.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pause for COVID 19 Response","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pause for COVID 19 response","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pause for COVID-19 Response","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Paused for COVID-19 Response","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pediatric development program terminated by sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pending FDA review","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pending IRB approval at PI's new institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Pending IRB renewal","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pending Modification","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Pending approval of the Ethics Committee","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pending further evaluation","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pending modifications","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Pending production of human use 18F-FMAU","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Per Data Monitoring Committee recommendation","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Per Group Chair: This study will not move forward.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Per IRB COVID\u0089\u00db\u00f019 guidance on conducting human subjects research.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Per PI due to poor\/inadequate accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Per PI, results from another similar study were published prior to study analysis. Negative \u00ca study results were published therefore analysis was not completed","label_descriptions":["Another_Study","Negative"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Per protocol intermediate analyses of 76 patients and enrollment difficulties.","label_descriptions":["Insufficient_Enrollment","Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Per recommendation from DRT","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Per recommendation of the PI; slow accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Per sponsor decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Personelle changes mandated suspension.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pfizer has terminated the execution of this protocol","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pfizer made a business-related decision on 04May2017 to terminate study based on change in\u00ca portfolio prioritization, and is not due to safety or efficacy.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pharmaceutical co- re aligned their specialties- no longer will fund H&N ca","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pharmaceutical company has terminated orteronel (TAK-700) development for Prostate Cancer","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pharmaceutical company no longer manufactures drug","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pharmaceutical company supplying the drug withdraw financial support. PI has decided to close\u00ca study prior to enrollment of any patients.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pharmaceutical sponsor withdrew financial support.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Phase 3 clinical trial of somavaratan in PGHD did not meet its primary endpoint of\u00ca non-inferiority","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Phase I analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pilot data to be used for upcoming larger trial.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pilot results in change to protocol, new study needed.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Pilot study determined that this study would not be feasible.","label_descriptions":["Logistics_Resources","Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pilot study showed recruitment rates were lower than expected,and number of losses to \u00ca follow-up, much higher.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pilot study superseded by a larger NHMRC funded trial","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pilot study with sumatriptan found no significant changes in the primary outcome parameter\u00ca (change in CBF)","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Plan to change the trial design","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Planned number of 30 subjects could not be recruited during recruitment phase.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Planned to design a prospective study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Planning new study protocol","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Please Detailed Description for termination reason.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Please see Brief Summary for Termination Reason.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Please see Detailed Description below for termination reason.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Please see Detailed Description for termination reason.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Please see Detailed Description for the termination reason.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Please see Purpose Statement below","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Please see detailed description for reason why study was terminated.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Please see detailed description for termination reason.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor Accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor Accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor Enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor accrual","label_descriptions":["Logistics_Resources","Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor accrual and change of SOC (FOLFIRINOX in adjuvant setting)","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor accrual and response less than expected on interim analysis","label_descriptions":["Insufficient_Enrollment","Insufficient_Data","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor accrual and suspension of head and neck committee","label_descriptions":["Logistics_Resources","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Poor accural","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor compliance with the therapy and lot of patients were lost to follow up.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor enrollment and infeasibility of ever reaching the necessary sample size","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor enrollment, lack of feasibility","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor enrollment, unable to meet recruitment goals","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor enrollment; termination not due to safety reasons.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor intermediate-term results","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor patient accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor patient enrollment due to logistical issues","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor patient enrollment due to logistical issues.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor patient recruitment. Vast majority of the patients have exclusions criteria","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor recruitement","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor recruiting status","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor recruitment & not feasible to continue","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor recruitment and change in development strategy","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor recruitment and through put","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor recruitment of fast and slow acetylators","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor recruitment, poor patient compliance, lack of funding\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor recruitment.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor recruitment; study design not appropriate any longer.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor tolerability of drug and side effects","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Poor trial recruitment","label_descriptions":["Logistics_Resources","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Portfolio consolidation.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Portfolio proritisation","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Portfolio re-prioritization","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Positive FAIR-HF study data are available, this study is identical as EFFICACY-HF. Due to low recruitment in EFFICACY-HF the decision was made to terminate it.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Post-marketing reports of hepatotoxicity associated with obeticholic acid emerged in June 2017,\u00ca investigators temporarily halted patient recruitment June 2017.","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Potential hepatic safety signal","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Potential participants with COPD\/asthma unwilling to participate.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pre-Clinical Safety Tox Findings","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pre-specified futility boundary was reached.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pre-specified interim analysis of safety and efficacy is pending.","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Precautionary delay in response to the COVID-19 pandemic.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Preclinical finding","label_descriptions":["Success","No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Preliminary data showed [123I] MNI-308 not a useful tool in detection of AD.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Preliminary data showed no survival benefit in the GV1001 group compared to the gemcitabine group.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Preliminary data was inconclusive to warrant keeping the study open.","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Preliminary results of MK-5172 PN003 (NCT01353911) suggested a possible dose relationship to\u00ca elevated transaminase levels in treatment with grazoprevir.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Premature termination due to insufficient patient recruitement..","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Prematurely terminated based on interim study analysis","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Prematurely terminated due to financial considerations","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Prespecified no. of patients could not be accomplished within 18 months","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Previous studies have been done regarding same condition","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Primary (safety) endpoint reached","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Primary Investigator passed away.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Primary Investigator resigned from Hospital","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Primary Investigator resigned from hospital","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Primary PI left institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Primary endpoint (Safety) has been achieved","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Primary investigator is taking a leave of absence","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Primary investigator left VA employment","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Primary objective has been met; safety and pharmacokinetics have been characterized.","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Primary study outcome achieved; investigator decided to conduct the study without sponsor\u00ca support after 2009.","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Principal Investigator has left the UMDNJ","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator has left the institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator has transferred to another Institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator is leaving the UMDNJ","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator left Moffitt","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator left institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator left institution before study could complete.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator left the institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator left the institution before subjects were enrolled","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator made aware of similar studies that have already been published.","label_descriptions":["Study_Design","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Principal Investigator moving out of state, no other staff to lead research.\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator moving to a new institution where the study will be reopened","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator resigned position with the University of Cincinnati, closing study at this site will reopen study in new position\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal Investigator separating employment from University.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal investigator is leaving the institution to obtain further training.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal investigator left institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal investigator left institution.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal investigator left the university.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Principal investigator made the decision to close study and not submit a renewal. Lack of fixed\u00ca research personnel to carry out the study effectively.","label_descriptions":["Logistics_Resources","Study_Design","Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Principle Investigator was deployed to NYP to help with COVID-19 response team","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Prinicipal Investigator separating employment from University.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Prior to recruitment, study terminated lack of recruitment interest.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Problem with recruiting participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Problems of recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Problems recruiting; patient relapse following treatment","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Problems with accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Problems with data collection","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Problems with patient recruitement","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Problems with planned computer","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Procedure protocol improved - study protocol became obsolete","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Product no longer will be developed by Alseres.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Product withdrawn from distribution","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Production of adjuvant to be used with vaccine was discontinued by sponsor","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Program Development discontinued","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Program Terminated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Program discontinued","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Program discontinued based on GIPF-007 results","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Program terminated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Project Cancelled","label_descriptions":["No_Context","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Project end after 3 years; prolongation was rejected","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Project lacked funding.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Projected neutral significance for primary composite efficacy endpoint.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol 1634 (UI) and 1635 (UF) were combined into one protocol 1634 for OAB. Subject enrolled under 1635 will be followed under 1634 for OAB.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol Under Review","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol amendment pending, suspended during interim.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol approval expired","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol being revised","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol changes underway.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol closed based on new (and as yet unpublished) information from a phase II clinical trial.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol currently reviewed for updating","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol design under review.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol is withdrawn due to inadequate accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol modifications in response FDA alert for the use erythropoiesis-stimulating agents are pending final IRB approval","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol never received funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol not feasible as written","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol pre-specified interim analysis showed that difference between groups was too small to reach significance.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol to be re-designed (primary outome still GCSI)","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol was comparing to standard of practice, which has changed over the course of slow recruitment and no longer can be used as a comparator.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol was not feasible - only 1 of 18 enrollees completed procedures.","label_descriptions":["Study_Design","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol was stopped due to the safety issue in Global","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Protocol-defined outcome in terms of efficacy would not be achieved.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Publication of MA17 results (similar trial in the extented adjuvant setting with letrozole)","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Publication of recent trials showing no effect of EPO in TBI.","label_descriptions":["Another_Study","Negative"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Pupil measurement methodology determined not appropriate in this population.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Pursuing IND","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Question raised by Ethics Committee","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Questions of the benefit efficacy\/risks of ddI during the meal not resolved","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"RCT with same hypothesis ended and showed a superiority for protective ileostomy after lower anterior rectum resection.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Rami Komrokji, MD author of this protocol no longer is at the University of Cincinnati and this study has been withdrawn.\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Rate of cure was higher than expected, IRB suspended for no additional benefit\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Re-initiate a new trial per the discussion with FDA","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Reached early stopping rule.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Reactogenicity met study halting criteria","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Reallocation of funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recent FDA approval of a new drug for the same patient population","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recent abstract publication questioning the need for our study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recent improvements in clinical practice have reduced the apparent incidence of AMR in renal\u00ca transplantation.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recent similar studies have been completed and published showing no benefit to the\u00ca intervention.","label_descriptions":["Study_Design","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Recently published data that has shown HCQ to be safe when combined with chemo and or\u00ca radiation at even higher doses than what is used in this study.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Recommendation after interim analysis","label_descriptions":["Endpoint_Met","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recommendation of the Data Safety Monitoring Committee","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recommended Phase II dose determined","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Record is an ACRN grant summary & not reflective of an individual trial. All ACTs conducted by\u00ca ACRN were individually registered on the PRS.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitement was much slower than anticipated.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruiting halted prematurely and will not resume. New study to open soon.","label_descriptions":["Study_Design","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruiting or enrolling participants has halted and will not resume","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruiting or enrolling participants has halted prematurely and will not resume.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruiting or enrolling participants has halted prematurely and will not resume; participants\u00ca are no longer being examined or treated.","label_descriptions":["Business_Administrative","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruiting problems","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruiting took longer than expected due to a lack of eligible patients (very strong inclusion and exclusion criterias)","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment Goal of 20 Not Met","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment and enrollment to this study has been suspended due to the COVID-19 crisis.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment and follow-up has been completed.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment and organizational difficulties","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment behind plan, no increase expected\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment challenges","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment challenges and lack of funding caused an early end to this study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment concerns","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment difficulties","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment finished earlier, because all 40 patients enrolled\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment goals could not be met.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment halted as research group determined that they had sufficient numbers to determine if the intervention had an effect.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment has been suspended because of a problem with the software used for generating the aftercare summary.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment in study could not be reached after 8 yrs of recruiting","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment is suspended due to COVID-19 outbreak","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment is suspended due to COVID-19. Study visits for currently enrolled subjects are","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment is temporarily suspended due to COVID-19 outbreak","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment is temporarily suspended, related to COVID-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment issues","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment lower than estimated","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment not progressing as planned.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment of patients proved much too difficult based on the chosen criteria.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment on hold until IRB review completed","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment problematic","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment problems","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment problems has forced us to change the design of this study from a clinical trial to a comparative study of 3 different groups of patients.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment problems; insufficient number of new recruits","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment slow","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment stopped according to early stopping rule (by protocol)","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment suspended during PI leave X 12 months","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Recruitment suspended until DSMB reviews a Serious Adverse Event","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment suspending during the COVID-19 pandemic.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment targets were unachievable in the currently available population.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment temporarily on hold due to COVID-19 situation.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment temporarily paused due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment temporarily paused due to COVID-19 and expected to resume.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment temporarily suspended due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment temporarily suspended due to COVID19 restrictions.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment temporarily suspended.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment to slow, most patients to well for treatment\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment too slow. Number of eligible patients probably to low. Patients enrolled and\/or in follow-up will be followed up in the Valeo study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment very difficult. Study drug expired so we have stopped the study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment was early terminated due to slow recruitment. Not linked to any safety concern.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment was slower than anticipated. Insufficient funding to expand to multi-centered trial.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment was suboptimal","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment was taking longer than originally anticipated.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment was too difficult","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment was too slow and we cannot anticipate to recruit the target sample size","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment was very slow.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment\/study discontinued after withdrawal of marketing authorisation. No data entered.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Recruitment: Insufficient number of patients eligible for enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Redirect focus of the indication","label_descriptions":["Business_Administrative","Study_Design","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Reduced access to AchEI medication-naive mild AD patients.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Redundant in-clinic visits increased the workload in virtual follow-up group. An interim \u00ca analysis showed that the study would not support the primary hypothesis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Refer to Detailed Description.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Registration is less","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Regulatory approval was not obtained for drisapersen, hence BioMarin is stopping the\u00ca development of all exon skipping oligonucleotides in DMD.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Regulatory decision not to proceed","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Regulatory issues(trial temporarily suspended December 28, 2005. Permanently suspended January 19, 2007. Institutional Reveiw Board informed April 18, 2007\"","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Regulatory reasons","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Rejected ethics approval in UK and Holland","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Reorganization of personnel forced termination.","label_descriptions":["Business_Administrative","Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Replaced by a new study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Replaced by another protocol","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Replaced with an alternate study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Replaced with another study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Replaced with ongoing study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Replacing this trial with a new trial.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Reports of significant laboratory abnormalities and adverse events in a number of clinical \u00ca study participants.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Reprioritization of study programs","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Repros decided to stop study because of safety and FDA decided to put study on hold.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Repros decided to stop the study because of safety and the FDA decided to put the study on hold because of safety.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Repros stopped study due to safety and FDA placed study on hold","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Repros stopped the study for safety and FDA put the study on hold for safety.","label_descriptions":["Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Request for early termination is based on a competing study OHSU is participating in","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Request to close per funding sponsor. Site not moving forward with trial.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Research and Development priorities were re-assessed.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Research never begun.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Researcher changed jobs. Unable to carry out the project","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Resident project--resident left institution and was not picked up by anyone else","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Restructuring and refocus of company.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Results from Study 2 did not support \"dismantling\" and suggested a focus on alternative\u00ca targets of intervention (e.g., emotion regulation, self control)","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Results inconclusive","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Results of an interim analysis and a hardly ongoing enrolment in the last 10 months in all six \u00ca participating centres","label_descriptions":["Insufficient_Enrollment","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Results of interim analysis indicate lack of efficacy when compared to placebo.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Results of step1: none of the experimental arms fulfills expectations and the study will not \u00ca continue as a phase III.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Results of the interim analysis suggested no significant diff between study groups.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Results showed statistically significant benefit in the experimental group","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Results unlikely to impact treatment patterns. Time to complete not justified.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Retirement of PI","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Retirement of the Principal Investigator","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Review Board stopped the study after interim analysis reaching stopping rule for efficacy.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Review of primary endpoint data by study Investigators concluded no further patients required.","label_descriptions":["Success","Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Rights for the further development of drisapersen have been transferred to Prosensa.\u00ca Therefore this study has been cancelled before enrollment.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Risk Status of study currently under review","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Rofecoxib was withdrawn from the market due to safety concerns.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"SAE- risk of overall protocol treatment outweighs benefits","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"SAEs with n=1 serotonin syndrome, n=2 SAEs after sertraline interruption.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"SNUH-NM-333 ligand effect was judged to be insufficient.","label_descriptions":["Endpoint_Met","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"SP arms were stopped due to high levels of treatment failure.CD not available.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"STEBA decided to develop WST11 that is soluble in aqueous solutions. The property of WST 11 \u00ca make it safer and better candidate for therapeutic applications.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"STUDY WAS NOT STARTED","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"SUSPENDED (Due to COVID-19)","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"SWOG has decided to not pursue this trial","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety Issue: The trial was prematurely terminated on Dec 9, 2010, due to safety concerns,\u00ca specifically new emerging evidence of hepatic injury.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety Issues","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety Review","label_descriptions":["Study_Design","Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety concerns","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety concerns in the treatment arm","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety concerns related to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety concerns with the COX-2 specific inhibitor class of drug.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety concerns.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety evaluation due to recent publications.","label_descriptions":["Safety_Sideeffects","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety issue","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety issue observed on another hepatocellular study using OSI906","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety issues","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety issues related to outpatient intravenous infusion in India","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety of patients","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety reasons","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety reasons, though no safety issues arose.\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Safety-related","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sangart ceased operations","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sanofi-Aventis wanted the study terminated.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sara Cheng, MD has left the Univ. of Colorado and the study has been closed.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Scientific data called into question the viability of the substance class","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Scientific review positive from 3 manufacturers; internal committees did not support due to \u00ca deploying new flu vaccines in HIV+ pregnant women in Kenya.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Screening has been suspended based on a recommendation from the Dose Selection Committee. There are no safety concerns involved in this decision.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Secondary to third interim analysis by the study DSMB.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See Detailed Description","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See Detailed Description field","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See Detailed Description field.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See Detailed Description for Termination Reason","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See Detailed Description for termination reason.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See Detailed Description.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See Termination Reason in Detailed Description","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See Termination Reason in Detailed Description.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See detailed description","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See detailed description for reason.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See detailed description for termination reason","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See reason for termination in detailed description.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See statement in Detailed Description.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See termination reason in detailed description","label_descriptions":["No_Context","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See termination reason in detailed description.","label_descriptions":["No_Context","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"See the termination reason in detailed description.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Seeking additional funds","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Senior management decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Senior managemnt decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Serious adverse events with prednisolone, primarily temporary growth retardation, <5th\u00ca percentile.","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Several enrolled subjects experienced hypotensionafter receiving Nicardipine and after revier the Principal investigator decided to stop enrollment.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Shortage of required study drug.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Side effects valuation","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Significant Adverse Effects - Futility","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Significant Toxicities Experienced","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Significant changes have been made to the protocol.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Significant discrepancies between KOH and mycological culture results, and a lower than expected mycological cure rate\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Similar data obtained in another study [see NCT01085045], therefore study not implemented.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Similar study completed.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Since only 1 of the first 10 subjects responded to the study treatment, it was decided to stop\u00ca the trial due to lack of efficacy .","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sister trial has SAE investigation underway - sponsor elected to withdraw as study expected to \u00ca be repeated later","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Site Principal Investigator became seriously ill, so study abandoned before the start of recruitment\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Site decided not to move forward with trial. Study never opened to enrollment.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Site did not enroll any patients to the study.","label_descriptions":["Insufficient_Enrollment","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Site did not recruit any patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow Accrual","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow Accrual.","label_descriptions":["Business_Administrative","Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow Enrolling","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow Enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow Recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual and anticipated loss of funding","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual and lack of resources and priority due to combining 2 consortia","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual and loss of sponsor","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual and no cost extension not approved by NHLBI","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual led to early study termination.","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual than anticipated.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual, Funding stopped","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual, competing clinical trials","label_descriptions":["Insufficient_Enrollment","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual, study terminated.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual. 100 patients included","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual; drug availability","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrual; study terminated.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accruals","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow accrural to study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrollment","label_descriptions":["Logistics_Resources","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrollment [HIGH SCREEN FAILURE RATE]","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrollment and administrative reasons","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrollment and business decision. No safety concerns were identified for the study drugs.","label_descriptions":["Business_Administrative","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrollment and due to personnel change there was no viable way to quantify glycine levels through imaging","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrollment and due to personnel change there was no viable way to quantify glycine levels \u00ca through imaging","label_descriptions":["Insufficient_Enrollment","Study_Staff_Moved","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":true,"Success":false}
{"text":"Slow enrollment decreased sample size No unexpected safety issues.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrollment due to multiple screen failures","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrollment rate.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrollment; Lack of support and equipoise","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrollment; study terminated.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrolment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrolment and end of funding","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow enrolment of patients and new insights","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow inclusion","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow patient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow patient enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow patient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow rates of accrual in North America, enrollment of more than 100 patients in a global study to confirm safe dose.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment and high dropout rates","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment and inability to extend funding.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment and no further drug supply","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment of patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment rate","label_descriptions":["Logistics_Resources","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment rate into this study with rare tumors of neuroendocrine origin (enrollment\u00ca issues)","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment, cessation of funding","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment, investigators not wishing to continue with randomisation and a decision to rationalise this product from the Sponsors portfolio.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment, stopped after 4 years\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow recruitment; Study did not address safety concern raised by European Medicines Agency","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slow, insufficient accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slower than anticipated enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slower than anticipated recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slower than anticipated recruitment and stopping criteria defined in protocol resulted in early termination of study.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slower than expected recruitment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Slowly recruitment rate. Intermediate analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sluggish enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sluggish enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Some patients experienced asymptomatic, transient elevations in liver transaminases\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sorafenib administered in the combination with pemetrexed-carboplatin appears to enhance thrombocytopenia compared to historical data.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor - Confluent Surgical terminated study re: surgical techniques Letter dated 4\/31\/2008","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor Decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor Decision- Financial Considerations","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor Terminated","label_descriptions":["Business_Administrative","No_Context"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor business decision, not based on safety or efficacy data\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor business decision, not based on safety or efficacy data.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor chose not to pursue indication for erectile dysfunction","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor closed enrollment early based on interim data from the PRISM US Pivotal Study.","label_descriptions":["Insufficient_Enrollment","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor closed study due to poor enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor closed the study in order to review data from other ongoing tesevatinib oncology\u00ca studies, and to determine feasibility of continuing this study","label_descriptions":["Interim_Analysis","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decided against going forward with the study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decided not to continue with the development program","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decided not to go forward with the study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decided not to move forward","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decided to discontinue study drug development","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decided to discontinue study drug development.","label_descriptions":["Business_Administrative","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decided to stop enrollment to review data.","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decided to terminate the project due to low multi-center enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decided to terminate the study due to budget consideration","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decided to withdraw from study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision because of to small enrollement","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision due to low recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision due to low subject recrcuitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision not related to patient safety","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision not to enroll cohorts of combined SGN-35 and gemcitabine therapy.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision not to proceed with study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision to stop the study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision to terminate study, not due to safety reasons.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision to terminate study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision to terminate the study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision to terminate.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision to withdraw study at this time.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor discontinued development of CO-1686 for NSCLC","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor discontinued development of CO-1686 for NSCLC.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor discontinued the research","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor discontinued the study following the discovery of a number of incompletely sealed batches that were unusable.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor elected not to conduct study at this time.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor elected not to continue with study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor elected to not pursue this indication for the study device.","label_descriptions":["Business_Administrative","No_Context"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor halted study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor has decided to not proceed with this study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor has designed another study to replace the current study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor has withdrawn support for this study and it will not be performed","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor has withdrawn the funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor is not proceeding with USA human trial at this time","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor is re-evaluating the clinical development path","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor issue","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor no longer funding study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor no longer pursuing regulatory approval of investigational device","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor pulled funding secondary to economy issues","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor requests final closure of this trial.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor stopped due to difficulties to recruit 130 patients required by protocol","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor stopped due to difficulties to recruit 402 patients required by protocol","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor stopped program]","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor stopped the study because of lack of elligible participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor support withdrawn","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor suspended study do to funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor terminated RRMS studies as sufficient long term clinical data was collected for the\u00ca study drug in the relevant dose","label_descriptions":["Endpoint_Met","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor terminated due to no enrollments within last 4 months.","label_descriptions":["Business_Administrative","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor terminated study early due to limited enrollment and follow-up.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor terminated study prior to initiation.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor terminated trial","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor terminated.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor withdraw","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor withdraw from this study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor withdrew IND from FDA","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor withdrew drug.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor withdrew funding prior to study initiation","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor withdrew request to conduct study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor withdrew support","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor withdrew the funds because the smell of sodium butyrate made blinding impossible","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor's Decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor's decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor's decision due to absence of demonstration of efficacy of volinanserin in primary insomnia with predominant sleep maintenance problems","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor's decision due to negative result of Phase 3 study TH-CR-406\/SARC021","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor's decision not to pursue development of uPLi for vascular conditions","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor's decision not to pursue development of uPLi for vascular conditions.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsor's decision to not pursue uPLi for vascular conditions including DVT.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsoring company ceased business operations","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsoring company ceased business operations.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sponsors decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Staffing and departmental changes at our site made it difficult to enroll subjects.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Staffing issues prevented the continuation of the study","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Staffing resources currently being restructured","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stage 1 accrual completed. Study did not proceed to Stage 2 accrual.","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Statistical interim analysis showed valid and significant results","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sterility problems in DepoCyte production","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped at interim analyses phase due to lack of efficacy","label_descriptions":["Endpoint_Met","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped at the request of the Data Safety Monitoring Board for safety reasons.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped by DSMB due to increased wound infection rate.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped by the DSMB due to a trend toward more adverse events in the higher hemoglobin (Hb) arm and &lt;5% chance that the study would show benefit for higher Hb.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped early","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped early by DSMB due to slow enrollment - obtained data to be analyzed","label_descriptions":["Insufficient_Enrollment","Study_Design","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped early due to inability to recruit full 100 subjects over 2 years","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped early due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped enrolling subjects due to challenge of identifying eligible participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped for futility","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped for futility by DSMB","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped the study due to feasibility issues, no enrollment has taken place.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped until further notice due to COVID-19 restrictions","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopped with Patients","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Stopping rule-acute rejection threshold-was met based on local biopsy results","label_descriptions":["Endpoint_Met","Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Strategic Business Decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Strategic business decision (not related to safety or efficacy concerns)","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Strategic business decision not to pursue indication due to lack of demonstrable medical need","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Strategic company decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Strategic considerations","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Strategic decision of Sponsor","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Strategic decision unrelated to safety or efficacy","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Strategic decision was made to terminate the AFM11 development","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Strategic reasons of the company","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Studies are suspended until a new ultrasound scanner is acquired.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study AFF006A was early terminated by the sponsor based on the results of study AFF006.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study C11-01 started","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study Cancelled before enrollment","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study Completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study D2276C00001 was not started. No patients were enrolled. The sponsor decided to pursue an \u00ca alternate design.","label_descriptions":["Business_Administrative","Study_Design","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study DAR-312 did not meet its primary co-endpoints.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study DAR-312 did not meet primary co-endpoints","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study Never Initiated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study PI moving to a different institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Study PI resigned","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Study Stopped","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study Terminated - Company decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study Terminated - No enrollment, business decision.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study abandoned.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study abandoned; Could not obtain final SRC approval due to IND disagreements","label_descriptions":["Regulatory","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study accrual rate is very slow, it was mandated by NCI to be terminated.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study accrual rate is very slow, it was mandated by NCI to be terminated.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study approval deferred by the IRB.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study being rewritten","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study cancelled because recruitment rate was too slow","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study cancelled before protocol was implemented.","label_descriptions":["Business_Administrative","No_Context"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study cancelled prior to FSI","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study cancelled.","label_descriptions":["No_Context","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed &amp; recruitment will not recommence","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed Nov 2000 by Amgen, who stopped drug delivery\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed at Mayo prior to completion","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed by Institutional Review Board","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed by PI due to lower than expected accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed by Protocol Review Monitoring Committee because of lack of accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed by sponser","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed by sponsor. Funding ended.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed due to insufficient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed due to lack of funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed due to lack of recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed due to low accrual.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed due to low enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed due to recruitment challenges.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed due to slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed due to unanticipated toxicity\/risks to subjects.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed early due to poor accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed early, because of low enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed prematurely","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed to accrual due unfavorable interim analysis","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed. Difficult enrollment of patients with prostatitis.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study closed. PI left the institution.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Study completed","label_descriptions":["Endpoint_Met","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study completed.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study concept was terminated.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study could not be re-supplied with study medication in a timely manner.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study currently suspended due to a lack of available funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study deemed non-essential under COVID pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study delayed for over a year by research shutdown at Seattle VA and other issues. Study designer moved to Ann Arbor in the interim, so the study was closed.\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Study design changes were needed based on GIPF-001 results","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study design has been substantially revised and a new registration will be made in the future.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study design was altered such that a treatment component was removed through the VA IRB. We did not and will not begin this clinical trial.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study design was changed and is now listed as InSite for Urinary Urge Incontinence and InSite for Urgency-Frequency","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study did not get started.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study did not receive IRB approval, so did not start","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study did not start due to investigator time constraints","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study did not start.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study discontinued after Part A due to Sponsor's discretion.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study discontinued based on planned interim analysis of the primary endpoint. Not linked to\u00ca any safety concern.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study discontinued due to data quality issues.","label_descriptions":["Study_Design","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study discontinued due to poor accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study discontinued.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study discontinued. Superseded by NCT02973893 VF00102.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study drug administration discontinued based on benefit-risk profile.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study drug currently unavailable","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study drug expiry date not extended","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study drug is no longer supplied by grantor.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study drug supplier withdrew support for the study. Study was withdrawn from the Duke IRB.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study early terminated due to lower drug exposure","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study ended","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study enrollment significantly below protocol expectation","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study enrollment significantly below protocol expectations","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study enrollment was halted due to slow accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study enrollment was stopped due to insufficient subject accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study failed to accrue any patients due to regulatory issues with PR1 vaccine and T cell \u00ca production.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study funding ended","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study funding was withdrawn by the sponsor following agreement that slow patient recruitment warranted a new approach.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study had to be withdrawn because financial support was cancelled.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study halted by drug manufacturer","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study halted due to low recruitment. The 3 participants at time of termination transferred into study P04538 (NCT00727077). See NCT00727077 for details\/results.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study halted on Korean PI request, to await ACIP evaluation of febrile seizure reports and final CDC recommendation regarding product useage\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study halted prematurely and will not resume; participants are no longer being examined or\u00ca receiving intervention.","label_descriptions":["Business_Administrative","Study_Design","No_Context"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study halted prematurely due to COVID-19 but potentially will resume","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study halted prematurely due to COVID-19 but potentially will resume.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study halted prematurely, prior to enrollment of first participant.\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been completed as planned","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been halted after completing Stage 1, for corporate reasons. No future patients will be enrolled or treated.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been suspended due to reconsideration of study design.","label_descriptions":["Business_Administrative","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been temporarily suspended due to funding issues.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been terminated due low recruitment of participant population.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been terminated due to lack of accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been terminated due to logistical barriers to cell processing.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been terminated due to poor accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been terminated early due to financial constraints.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been terminated. Interim analysis results showed evidence of safety without efficacy of ODSH in patients with acute exacerbation of COPD.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been termination early due to financial constraints.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has been termination early due to financial contraints.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has never started","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study has now been terminated due to changes in project strategy. Current available data will be analysed and reported in a synoptic study report.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study inactivated due to detection of hyperintensities of unclear etiology on brain MRI. Protocol discontinued with clinical &amp; radiological follow up continuing","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is being delayed.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is being redesigned","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is complete Analysis is complete","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is completed and analysis completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is completed; data analysis are completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is currently Lapsed","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is hold for analysis to date.","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is no longer funded.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is now terminated due to technical difficulties with administration of study drug in this patient population with this schedule","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is prematurely ended due to poor patient recruitment rate.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is replaced by MI-CP198 per CPM.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is temporarily suspended due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study is withdrawn due to unavailability of eligible subject population. We will request the sponsors to extend the time for enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study medication expired","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study methodology redesigned","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never activated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never activated\/opened as funding source and other support not available.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never enrolled any subjects before auto-terminated by the internal IRB.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never initiated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never initiated due to contract manufacturing issues","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never initiated, new technology acquired for Oxygenation measurements\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never initiated.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never started","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never started at our site Funding issue","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never started.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never started. Study suspended indefinitely.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study never submitted to IND. Study is being sponsored by Johnson and Johnson in the EU only.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study not being conducted","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study not initiated","label_descriptions":["No_Context","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study not started","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study not yet started. Decided not to do the study. Considering more robust design.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study objectives met so study concluded earlier than planned hence we terminated the study.","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study on enrollment hold as a precaution per the pharmaceutical company.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study personnel left institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Study prematurely discont_\u0082\u0085d 20-Apr-2006 after interim analysis suggested sample size could be reduced without losing power. No safety concerns led to decision.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study prematurely terminated due to safety concerns leading to clinical hold","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study product is no longer being considered for further development.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study proved difficult to recruit","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study pulled due to a grant disagreement between the U of M and SMDC","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study put on clinical hold by FDA. Sponsor decided to no pursue the study.","label_descriptions":["Business_Administrative","Regulatory"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study re-design","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study re-designed","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study recruitment has been temporarily paused due to COVID-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study recruitment paused due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study recruitment suspended during COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study recruitment temporarily halted as a precautionary measure due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study recruitment temporarily halted as a precautionary measure due to the COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study recruitment temporarily halted as a precautionary measure due to the COVID-19 pandemic.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study recruitment very slow.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study redesigned and re-submitted to UAMS IRB under different study title and IRB number.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study site change","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Study site collaborators withdrew from participating due to time constraints.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study sponsor decided to withdraw the current study prior to enrollment of first participant.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study sponsors withdrew support for the study drug.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped and data not analyzed","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped as it would not address important survival concerns raised in other recently conducted clinical studies.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped at the end of the first step","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped because of disappointing inclusion rates","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped because of toxicity concerns.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped due to a lack of enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped due to increased cardiovascular risks associated with Celebrex","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped due to increased harm and slow progress in the intervention group.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped due to lack of efficacy.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped due to lack of elegible patient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped due to low accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped due to non-approval of IEC to proposed change in locations. Study discontinuation not due to safety\/efficacy reasons related to the vaccine.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped due to poor enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped early based on interim results of another trial, showing inferior activity of pemetrexed\/carboplatin compared to etoposide\/carboplatin in SCLC.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped early due to slow accrual.","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped following management decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped per Novartis request due to futility from another study.","label_descriptions":["Business_Administrative","Another_Study","Negative"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped prematurely due to enrolment challenges.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped prior to subject administered first dose, due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopped to avoid treating enrolled subjects to hemoglobin levels higher than those specified in current labeling.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study stopping criteria was met","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study subject enrollment difficulties","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study subjects were not able to be recruited","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study suspended because of safety reasons","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study suspended by decision strategically.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study suspended due to logistical\/personnel difficulties","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study suspended due to low accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study suspended due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study suspended due to the Covid19 virus until further notice","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study suspended for interim data analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study suspended until funding secured","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study temporarily halted as a precautionary measure due to the COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study temporarily on hold due to COVID19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study temporarily suspended until funding can be secured.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated 7\/23\/2019 due to limited participation and testing challenges.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated after 9 subjects completed due to lack of enrollment for 6 months","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated as a result of interim analysis not meeting predetermined criteria.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated as a result of the dissolution of the Sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated as ongoing analysis suggested objectives not practical to achieve with study \u00ca as implemented","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated as principal investigator [PI] left the university.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Study terminated at Sponsor's request.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated at UT MD Anderson Cancer Center site.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated based on DSMB recommendation in December 2006","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated based on decision of Sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated because unable to obtain access to study drug for study population.","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated by Principal Investigator; no patients completed study.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated by Sponsor following a recommendation from external DMC based on lack of\u00ca emerging benefit; there were no new emergent safety findings","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated by University of Miami Institutional Review Board","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated by sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated by sponsor due to bad risk\/benefit ratio.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to FDA alert regarding Fleet phosphosoda","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to business decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to declining enrollment; data analysis proceeding.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to halt in funding; may resume recruiting in future","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to inadequate recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to insufficient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to insufficient subject participation","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to lack of care guidelines in the protocol.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to lack of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to lack of efficacy of GSK2798745 in chronic cough.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to lack of eligible patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to lack of enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to lack of response at the first efficacy analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to low accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to low enrollment making it unlikely to meet recruitment goals.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to low enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to low patient enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to low recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to low subject enrollment. Safety results consistent with product label.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to no apparent benefit.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to poor recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to slow enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated due to withdrawl of participating co-investigators.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Study terminated early as per request by sponsor, Zila Biotechnology, Inc.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated early based upon development of another anti-IL17 fully human monoclonal\u00ca antibody with better potential for treating MS patients","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated early due to difficulties in subject recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated early due to lack of enrollment.","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated early due to slow accrual","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated early, no participants enrolled.\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated for business reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated for cGCP Study_Design. Analyses could not be performed.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated for lack of accrual.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated for re-design. A new IND study (US FDA, July 2009) will be conducted in US and Taiwan. Termination not related to safety concerns.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated for safety and the FDA put the study on hold for safety.","label_descriptions":["Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated on 15DEC2016 due to study A8241021 showing no significant difference on\u00ca primary endpoint between PF-02545920 & placebo. No safety concerns.","label_descriptions":["Another_Study","Negative"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated on Nov 7, 2008 as a result of poor recruitment and changes in business priorities. The decision was not based on safety concerns.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated per recommendation of Data Review Team","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated prior to initiation","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study terminated when aripiprazole available commercially per protocol","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study termination due to insufficient efficacy.","label_descriptions":["Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study to be revised. Future plans to be determined.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study treatment and recruitment has been paused due to COVID-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was administratively withdrawn by the IRB; no subjects were enrolled","label_descriptions":["Business_Administrative","Regulatory"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was cancelled","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was cancelled before patient enrollment","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was cancelled by Sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was closed June 23, 2008 due to low enrollment.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was closed due to administrative reasons; study did not enroll any participants.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was closed due to extremely low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was closed due to logistical issues.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was closed permanently before the accrual goal was met due to slow accrual","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was closed to accrual because imaging agent was no longer available.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was closed to enrollment before dose level one was completed.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was combined with Mayo protocol 07-003476","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was completed.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was discontinued based on futility analysis done and not based on safety concerns.\u00ca Follow-up visits and closing out study activities are completed","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was discontinued because of high drop out rate.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was discontinued due to FDA recommendations of the potential toxicities of the\u00ca combination of drugs.","label_descriptions":["Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was discontinued due to lack of accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was discontinued due to non-safety related business prioritization decisions","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was discontinued.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was halted due to poor subject accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was halted early after 63 subjects were enrolled due to slow accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was never able to start in IRAN","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was never funded.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was never initiated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was never initiated due to company decision. No study subjects were ever enrolled or \u00ca dosed.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was never initiated due to lack of funding support.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was never opened","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was never opened to accrual. There is no clinical benefit to patients.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was never started","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was not funded.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was not initiated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was not initiated and has been withdrawn due to lack of appropriate cases","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was not initiated. No subjects were screened or enrolled.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was not started and participants were not enrolled","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was prematurely terminated at the time of the first Interim Analysis (IA) as the study\u00ca did not meet its primary efficacy objective.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was previously paused and is now terminated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was previously suspended and is now terminated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped after enrolment of about 200 patients for slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped after pre-definied interim analysis because of no effects","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped as the sponsor is no longer funding this project","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped because of ineffectiveness of one investigated Drug","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped because of safety concerns.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped by sponsor prior to first patient assignment to groups due to operational reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped by the principal investigator due to nonsatisfactory clinical benefit even in\u00ca patients treated at the highest dose (200 mg ).","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped due to approved label expansion of alglucosidase alfa.","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped due to difficulties in recruitment and changes in standard care for invasive aspergillosis","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped due to difficulties in recruitment and changes in standard care for invasive\u00ca aspergillosis","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped due to difficulty in patient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped due to lack of resources (clinical dietitians).","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped due to perceived futility because the baseline pain score in first 40 patients was too low to be able demonstrate an improvement","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped due to restrictions in labeling for the subcutaneous route of administration of EPREX.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped due to slow accrual of patients.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped due to time dependent drug accumulation","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped early due to lack of efficacy signal and safety concerns","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped following interim analysis.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped prematurely due to poor recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was stopped shortly after initiation due to change in strategic direction of the company; no safety concerns were observed that impacted this decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated according the study protocol end of 2007","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated after unplanned interim analysis of single centre data and results were\u00ca reported","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated because of poor enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated by sponsor due to market authorization of tocilizumab for the study\u00ca population.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated by the sponsor due to low accrual.","label_descriptions":["Business_Administrative","Insufficient_Enrollment","Insufficient_Data","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to administrative reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to cardiac toxicities","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to cardiac toxicities in the subejcts","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to cardiac toxicities in the subjects","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to futility","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to inability to recruit and collect follow up outcome data.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to insufficient funds","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to lack of available funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to lack of enrollment and businesss decisions.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to lack of enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to lack of funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to lack of recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to low accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to low enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to poor enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to slow accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to slow, insufficient accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to sponsor portfolio decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated due to withdrawal of CRADA partner.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated early (10 July 2015) based on preliminary analysis of pharmacokinetic\u00ca data.","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated early because of slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated early due to lack of experimental medication (supply issues)","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated early due to slow recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated early for business purposes and as a result of a strategic decision to\u00ca shift focus to another indication.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated early to allow subjects to roll over to study NCT02102204.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated for commercial reasons, no patients were enrolled\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was terminated for futility following the planned interim analysis.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was withdrawn due to a business decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was withdrawn due to lack of patient enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was withdrawn due to lack of resources.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was withdrawn due to unanticipated hassle in patient recruitment.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study was withdrawn prior to patient dosing based on a business decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study will not be initiated as planned.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn at sponsor request.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn because of internal business reasons not related to patient safety","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn due to budget (personnel) limitations.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn due to business decisions. No subjects were treated.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn due to lack of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn due to logistic reasons and will be re-organized at a later date","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn due to personnel limitations.","label_descriptions":["Logistics_Resources","Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn for financial problems. We didnwt get a grant we needed for purchesing the medication for the study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn from IRB","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn from IRB approval process by PI","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn prior to enrollment due to AZ business decision unrelated to safety.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Study withdrawn with intent of persuing larger, multi-site study.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Study_Design","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Sub-investigator left facility prior to study initiation","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Subject Recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Subject accrual was prematurely terminated due slow enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Subject population not available.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Subject recruitment was slow, so enrollment has been closed.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Subjects declined enrollment; sponsor\/PI elected to close study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Subjects were no longer able to remain compliant with follow-up intervals","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Subsequent data generated by our collaborators have shown efficacy with curcumin and quercetin in 5 patients in a non placebo controlled trial.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Substance discontinued","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Substance was withdrawn from further development.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Sufficient data regarding the dose-response to MK-0893 had been obtained from the first cohort\u00ca of the study to assess the safety and efficacy","label_descriptions":["Success","Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Sufficient evidence of efficacy not met. Discontinuation not based on any safety concerns.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sufficient mature data to complete a final analysis","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sufficient number of subjects accrued to conduct analysis","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Sufficient study funding was not obtained.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suitable subjects could not be recruited within the estimated time frame and via the objected ways of recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Supplement expired and unable to obtain more from company manufacturing","label_descriptions":["Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Supply Omega-3 Fatty Acids expired and supplier no longer made same composition.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Support for investigational products has been withdrawn.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Support issue.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Surgeon doing procedures amenable to this study left institution.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Surgeon mistakenly removed liver and fat tissue from a non-LABS2a participant","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Surgical approach changed therefore subject enrollment not possible.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Survival advantage demonstrated","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"Suspended","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended (Due to COVID-19)","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended (Due to Covid-19)","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended [Owing to the Covid-19 epidemics, investigators have decided to suspend inclusion on","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended by University of Miami Institutional Review Board","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended due to COVID-19 situation","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended due to Covid-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended due to funding issues.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended due to lack of funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended due to lorcaserin recall","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended enrollment and in person follow-up visits due to the COVID-19 Virus","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended for treatment\/dosing analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended patient enrollment due to an ongoing dispute with the licensor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended pending an amendment to the protocol for IV administration of LBH589","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended to accrual due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended to modify recruitment process","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended until capitalization is completed","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspended while we determine if usable data can be collected from this device.","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspened for interim data analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspension due to a safety concern, while risk\/benefit is being assessed\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspension due to a safety concern, while risk\/benefit is being assessed.\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Suspension of licence for rimonabant by European Medicines Agency","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"TV-4710\/201 did not meet its primary endpoints in patients with SLE","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Taiwan FDA asked for seperating this protocol into one disease site per protocol.","label_descriptions":["Study_Design","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Technical Conflicts","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Technical difficulties coordinating study","label_descriptions":["Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Technical issues with RSA at main site and departure of Principal Investigator","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Technical problem","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporarily Suspended for COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporarily closed to accrual pending availablity of drug.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporarily closed to patient accrual per protocol design.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporarily halted due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporarily on hold due to FDA request for review.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporarily suspended due to Pandemic.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporarily suspended in between validating test systems.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporarily suspended to conduct interim analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporarily suspended. Currently seeking funds to continue study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary enrollment suspension to manage patient safety due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary halt of recruitment due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary loss of personnel","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary pause on enrollment due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary recruitment pause for COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary suspension by PI due to Covid-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary suspension due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary suspension of enrollment due to COVID-19 situation","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary suspension of screening\/Enrollment due to worldwide COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary suspension since March 13 due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary suspension since March 19 due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary suspension since March 20 due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary suspension since March 2020 due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary suspension since March 20th 2020 due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Temporary suspension since March 20th, 2020 due to COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated","label_descriptions":["No_Context","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated (Business Decision to pursue other indications)","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated (Decision by the Sponsor. The study was not terminated due to a safety reason.)","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated (halted prematurely) due to tolerability issues.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated - due to low accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated 4\/17\/07. Drug sponsor withdrew.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated Chikungunya diseases has regressed and no more patients was suffering","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated October 2009 (in 4th year) due to low enrollment and anticipated drug expiration November 2009.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated [See Detailed Description for Termination Reason.]","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated at 50% enrollment due to recent concerns about rosiglitazone","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated at request of sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated at the request of the financial sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated because of futility to continue, after planned interim analysis.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by DSMB; futility analysis showing Mg treatment not efficacious","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by IRB for continuing review","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by Sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by Sponsor: see details below","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by sponsor - Single dose safety objective achieved.","label_descriptions":["Business_Administrative","Endpoint_Met"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by sponsor due to general risk that aranesp caused tumor progression","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by sponsor due to lack of funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by sponsor due to low enrollment; see details below","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by study sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated by the University of Miami Institutional Review Board","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to a patent legal settlement","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to awaiting data from Phase II study.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to clinical trial material production delays","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to commercial considerations with no patient safety reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to continuing review","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to dose limiting toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to futility after interim analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to insufficient efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to insufficient efficacy over placebo in Study ATL1251\/038\/CL.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to lack of accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to lack of eligible patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to lack of patient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to lack of recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to limited enrollment and follow up.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to logistical barriers to cell processing and poor enrollment","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to low accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to low accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to low recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to low subject accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to no patient enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to poor accrual","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to poor enrollment and grade 3 toxicities noted during an interim analysis.","label_descriptions":["Insufficient_Enrollment","Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to poor recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to reasons unrelated to safety","label_descriptions":["Business_Administrative","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to safety concerns","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to safety concerns.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to slow accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to slow enrollment","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to suboptimal dosing schedule","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated due to surgeon preferences","label_descriptions":["Business_Administrative","Logistics_Resources","Study_Staff_Moved","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":true,"Success":false}
{"text":"Terminated due to the change of supplier and sponsor","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated early because the first phase didn't meet the endpoint.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated early due to a lack of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated early due to lack of study feasibility and poor patient recruitment","label_descriptions":["Study_Design","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated early due to slow accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated early due to slow patient accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated early due to slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated for administrative reasons not related to safety or efficacy","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated for expired continuing review","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated for futility by sponsor after a pre-planned interim review of data","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated for futility on 11\/30\/09 based on the recommendation of the DSMB","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated for futility reasons.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated for lack of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated for lack of resources to complete.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated for safety reasons","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated for site documentation and monitoring issues - not safety, study drug, or adverse event issues.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated in lieu of similar,competing large, multi-site study.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated in view of the C107 findings demonstrating efficacy at doses of 90 and 30 minutes","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated to financial cut","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated to focus on comparable trial, CLOMDS02507\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated, new protocol to be developed\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated: No longer recruiting.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated: Test article, Omontys, was recalled from the market; Enrollment has halted\u00ca prematurely and will not resume; participants are no longer being treated","label_descriptions":["Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated: We are no longer recruiting.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated: recruiting or enrolling participants has halted and will not resume because low protein diet is not feasible nor efficious.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated: recruiting or enrolling participants has halted prematurely","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terminated: recruiting or enrolling participants has halted.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Termination Date: 30Aug2018; Reason for termination: Lack of Efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Termination date was 20-Oct-2008. Subjects were monitored during the post treatment 90 day follow-up period (per protocol) resulting in LPLV 19-Jan-2009.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Termination due to poor accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Termination is due to a combination of a device defect potentially impacting the quality of the AD 923 IMP and a major change in corporate strategy.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Termination of study due to low enrollment. There were no safety issues.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Termination of study was due to safety reasons","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Termininated for business reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Terms for legal agreements between institution and Sponsor could not be made.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The 001 trial did not show benefit versus placebo","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The 20070201 study was terminated based on evaluation of Palifermin solid tumor data.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The 2008-09 North American peak influenza season ended prior to study completion.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The CARE Network DSMB recommended to the NHLBI that the MARS trial be terminated, based on a futility analysis with 55 randomized children.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The CIHR Financial support was withdrawn because of insufficient recruitment","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The Clinical Development Program for MGCD0103 is being re-evaluated","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The Co-Principal Investigator has moved and is no longer interested in continuing this study at this site.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The DMC detected an imbalance in safety outcomes between the two groups.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The DMC terminated the study on the basis of futility (insufficient clinical response).","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The DSMB recommended stopping the study due to safety concerns.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The DSMB recommended that the study be stopped as a result of concerns regarding safety and intolerability and insufficient evidence of efficacy.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The DSMB stopped the trial due to unacceptable side effects in the experimental arm which has \u00ca not yet been verified","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The DSMB supported termination of the trial due to slow recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The European Medical Agency granted a Paediatric Investigational Product-specific waiver on the\u00ca grounds that idelalisib is likely to be unsafe in paediatrics","label_descriptions":["Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The FDA IND application is paused due to additional required testing. The IRB protocol was closed prior to research starting.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The FDA changed the labeling for this agent, and we felt we could not offer it to patients on a non-surgical study.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The Hospital had the Unit of Stem cells Tranplantion suspended","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The IRB considered our trial risky. Although there were debates between investigators and IRB,\u00ca we terminated our trial in accordance with the suggestion of IRB.","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The Investigator-Coordinator has moved to Rennes University Hospital. It will be done under the\u00ca sponsor of Rennes University Hospital : NCT03686306","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The NHLBI BSMB recommended closure due to poor enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The Omega arm of this study was stopped for futility. The EDEN arm continues to recruit patients as a separate independent study.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The PI has determined not to continue the study.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The PI has elected to terminate study at this time","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The PI is currently completing a fellowship out of state. Upon completion of fellowship, PI plans to continue recruitment for study.\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The PI is no longer with Kentuckiana Cancer Institute. All current subjects completed. No further subjects will be enrolled. Terminated with IRB.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The PI left the institution.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The PI moved to another city and position","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The PI, who was sponsor got retired","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The Principal Investigator is no longer affiliated with the Study Site.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The Principal Investigator left Columbia University and chose not to re-initiate the study at new facility","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The Principal Investigator left the clinic and there was no one who could take over this study.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The Sponsor (Amicus Therapeutics) terminated this study for logistical reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The Study was terminated on May 24th 2012 due to a slow recruitment rate. The study was not\u00ca terminated for reasons of safety or efficacy.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The Trial could not get permit from Department of Health, Taiwan; Furthermore, no research fund could support the expensive (photosensitizer) photosan\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The VA IRB would not allow demented subjects to be entered in this study.","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The accrual rate was not high enough to reach the target sample size.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The biological effect seen with natalizumab was not sufficient to warrant further development in RA.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The biological effect seen with natalizumab was not sufficient to warrant further development\u00ca in RA.","label_descriptions":["Endpoint_Met","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The buccal arm of the study was 30% less effecrtive in stopping seizures within 10 minutes compared with the IV dose. This met a stoppimg rule for the study","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The clinical study has been terminated based on difficulties to enroll eligible subjects per protocol inclusion and exclusion criteria.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The clinical use of Campath for transplant patients was temporarily suspended.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The company providing study IMP was unable to supply further batches of IMP.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The compound has a benign safety profile with short-term use, clinically sig efficacy responses have not been demonstrated, or if so, have not been sustained.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The correlation coefficient at the interim analysis with results for all three groups pooled,\u00ca did not reach the level of statistical significance of (p<0.05).","label_descriptions":["Endpoint_Met","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The data available is enough for the publication and the study article published in Middle East Journal of Anesthesiology.","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"The decision is based on company re-evaluation of indications to be pursued within SCCHN","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The decision of terminate the study was reached due to difficulties surrounding recruitment and enrollment of subjects since the inception of the study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The decision to close the NN2211-3619 trial was based on the very low recruitment rate as well\u00ca as challenges relating to trial execution and study completion.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The decision to stop the trial was based on efficacy results in the overall schizophrenia\u00ca patient population.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The decision to terminate this study after 202 mg\/m2 cohort was taken as MTD achieved in other study at 185 mg\/m2","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The decision to terminate was completely related to efficacy and there were no safety concerns.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The decision to terminate was for administrative reasons; there were no safety or efficacy concerns.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The development program has been terminated","label_descriptions":["Business_Administrative","Logistics_Resources","Invalid_Reason"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The differences seen between treatments led to recalculation of the sample, unattainable in a reasonable time","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The doses were not effective in maintaining testosterone suppression","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The drug company sponsor has withdrawn support.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The drug needed for the study is not available in Mexico anymore.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The enrollment is slower than expected","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The epidemic of COVID-19 has been controlled well at present, no eligible patients can be","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The epidemic of COVID-19 has been controlled well in China, no eligible patients can be","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The ethics committee did not approve the pharmacokinetic part of the study.","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The exclusion criteria were stringent and enrollment was slow.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The final assessments were conducted late and in a reduced format due to resource limitations\u00ca at the site.","label_descriptions":["Logistics_Resources","No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The grant application for this project was rejected.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The grant for this project wasn't funded, so there has been no enrollment. We are still hopeful\u00ca that the project will go forward some day, but not now.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The hypothesis that probiotics would reduce hepatic steatosis in humans was not supported","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The incidence of post-operative delirium observed from interim blinded data in DEX-06-09 was significantly lower than the current literature in this population.","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"The incidence of post-operative delirium observed from interim blinded data was significantly lower than the current literature in this population.","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"The intervention could not be successfully carried out in the SADP setting because of issues independent of the cognitive training intervention.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The introduction of oral propranolol as a highly efficacious agent for infantile hemangiomas","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The investigational drug is unlikely to demonstrate efficacy over placebo for this indication. \u00ca However, no safety issues were discovered.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The investigator at Cedars stopped this study due to problems collecting payment from the sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The investigators left the institution.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The investigators were not able to get grant funding for this study.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The laboratory's partner on this study decides to terminate the contract with the CHRU Brest,\u00ca because of the difficulty of the recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The last remaining subject withdrew consent because the collaborator Genentech stopped\u00ca supplying study drug.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The low accrual rate of the study (25% of the expected accrual rate)","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The maintenance doses were too low to maintain testosterone suppression","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The major and primary reason for the study termination is the observed reduced efficacy of CellCept compared to placebo.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The manufacturer decided to halt manufacturing the vaccine","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The manufacturer discontinued necessary reagents.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The number of enrolled subjects did not meet the goal during the study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The number of participants needed for this study has been met.","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The number of patients desired has been reached","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The number of successes is not reached at the end of first stage of the phase II. The study is\u00ca stopped.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The number of the anticipated participants was not achieved","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The numbers of drop-out patients are more than we anticipate","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The original PI, Alexander Neumeister, left NYULMC. No data was analyzed.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The orthopedic surgeon that does our knee surgeries has moved to a different location.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The overall profile does not support development for obesity","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The patient population changed. Unable to find patients that meet study criteria","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The patient population was not enough to complete enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The pharmaceutical company discontinued further development of SU5416.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The phase II portion was not conducted due to funding issue.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The planned enrollment was 130 patients and the study was halted prematurely due to lack of efficacy in both arms. Enrolled patients continued treatment.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The planned enrollment was 130 patients and the study was halted prematurely due to lack of \u00ca efficacy in both arms. Enrolled patients continued treatment.","label_descriptions":["Insufficient_Enrollment","Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The predecessor study A00309 (NCT00152464) did not show statistical significance in time to onset of asthma between the levocetirizine and placebo groups.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The preliminary data do not support the expected sustainable blood levels of triptorelin for a duration of 4 months in all patients.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The premature end of this trial was a business decision and not due to safety or efficacy concerns of the compounds.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The present study was joining 2005-41-4933 into one study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The program responsible for recruitment was dismantled in 2006.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The protocol finished.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The reason for the discontinuation of the study is difficulty with recruitment and timely\u00ca enrolment and is not related to safety concerns","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The recent outbreak and in anticipation of further spread of COVID-19, to protect the health","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The recruitment rate for the study was inadequate to achieve its enrollment goals.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The recruitment rate slowed considerably","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The recruitment rate was much slower than expected.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The recruitment rate was too slow according to study protocol and agreement.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The required results were obtained through alternate methodology","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The research project has been cancelled before any participants were enrolled.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The researcher had left the hospital and the project was stopped","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The response rate (5\/8) had reached a statistical significant endpoint.","label_descriptions":["Success","Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"The response rate observed in the phase 1 portion of the study did not merit further evaluation\u00ca in phase 2 portion of the study.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The results from the interim analysis were not favorable to continue this trial.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The results obtained 1 year after surgery were clearly indicative of the outcome and the investigators decided to terminate follow-up at that point.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The results obtained 1 year after surgery were clearly indicative of the outcome and the \u00ca investigators decided to terminate follow-up at that point.","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The results of a same study design have shown low response with important side effects. Accordingly &amp; ethicly, the study has been stopped.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The results of the dose escalation phase did not identify a well-tolerated dose that would \u00ca permit further study in Phase 2.","label_descriptions":["Study_Design","Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The results of this study will not be published due to the large number of losses to follow-up, which affected the results.\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The results were not able to be consistantly reproduced. Thus the trial was terminated","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The risk-benefit ratio for patients has changed since we initiated the study, and that the\u00ca study in its current form cannot be justified","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The risk-benefit ratio for the use of onercept in this condition was not sufficiently \u00ca favorable to justify continued development","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The safety profile of combination therapy became unacceptable.","label_descriptions":["Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The scientific commitee decided to stop the inclusions and exploit the results.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The site decided to stop the study","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The site is unable to recruit patients.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The sponsor decided to stop the study prematurely because of financial issues","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The sponsor decided to terminate the study due to slow enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The sponsor determined that adequate data had been acquired.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The sponsor did not provide the treatment","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The sponsor terminated funding for the study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The sponsor withdrew support for the study before any patients were enrolled.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The stopping rule for incidence of acute rejection was met.","label_descriptions":["Endpoint_Met","Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The stopping rule was applied because of low response rates.","label_descriptions":["Insufficient_Enrollment","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study chair changed his employment, the realization of the study was not possible\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The study crossed the prospective futility boundary of primary endpoint","label_descriptions":["Study_Design","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study did not achieve the statistical success to continue.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study did not open to accrual. No start date and no completion dates.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study did not recruit\/no study activity occurred.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study drugs are not covered anymore by insurance.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study encountered significant difficulties in patient enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study ethics committee recommended concluding the study for longer crying time with \u00ca benzocaine and very short crying time in all participants.","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study goals were accomplished by a similar study at UAMS. (W.J. Evans)","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study had poor enrollment with only 16 patients randomized across 19 study centers over an 18-month period.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study had poor enrollment with only 16 patients randomized across 19 study centers over an \u00ca 18-month period.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study has been halted prematurely due to a low recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study has been halted temporarily to mitigate the impact of the COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study has been halted temporarily to mitigate the impact of the COVID-19 pandemic.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study has been stopped because of the lack of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study has been stopped for logistic reasons not related to the safety or efficacy of the vaccine.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study has been terminated because too few patients have been recruited","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study has ceased recruiting as Ethics approval has lapsed and the investigator availability reduced.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study has finished.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study have been stoped because the protocol is going to be modify.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study is being discontinued due to administrative reasons that are unrelated to safety","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study is completed.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study is not a clinical trial.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study is out of date","label_descriptions":["Study_Design","No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study is prematurely terminated due to a safety issue","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study is temporarily paused due to COVID-19 and will resume based on guidance of public","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study is under hold.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study never opened and not sure if it ever will.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study never started.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study objectives became unachievable as a result of the termination of 0913M0621","label_descriptions":["Study_Design","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study population is smaller than expected. No subjects were included.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study sponsor canceled the study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study stopped after been paused (the patients were switched in the meantime)","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study stopped because the company's strategy.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study stopped prematurely due to and administrative reasons, not based on grounds of\u00ca safety.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study terminated for safety reasons.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was &quot;withdrawn&quot; due to certain adverse events [hypersensitivity].","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was cancelled before any patients were enrolled, due to operational reasons.\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was cancelled due to budget limitations","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was cancelled prior to the enrollment of any participants.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was closed because of lack of enrollment at all study centers due to challenges in this patient population.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was closed due to the departure of several of the co-investigators.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The study was closed early due to low enrollment and new information regarding the benefit of the study regimen.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was closed early due to slow patient accrual and sponsor's withdrawal of support.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was closed prematurely due to poor accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was closed to accrual due to the end of the clinical development program with\u00ca cixutumumab.","label_descriptions":["Study_Design","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was discontinued after the completion of dose escalation because of slow enrollment and minimal preliminary biological and clinical efficacy.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was discontinued after the completion of dose escalation due to minimal preliminary biological and clinical activity","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was discontinued after the first 10 patients because of discouraging results.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was discontinued early due to lack of funding and slow enrollment","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was discontinued prematurely at the end of March 2007 due to slow enrolment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was discontinued prematurely on 10AUG2009 due to low recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was discontinued prematurely on 25 February 2008 due to slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was discontinued prematurely on December 18 2008 due to slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was early terminated due to slow and difficult recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was halted due to futility concerns based on the unmet benchmarks as specified in the\u00ca pilot study protocol.","label_descriptions":["Study_Design","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was halted prior to enrollment of first participant due to non funding and recourses.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was incorporated in another study.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was never initiated","label_descriptions":["No_Context","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was not feasible","label_descriptions":["Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was not started due to a re-evaluation of the istaroxime development program","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was prematurely discontinued due to administrative reasons on August 18, 2003. There were no safety concerns that led to the decision to terminate.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was prematurely interrupted because patients randomized to CPAP reached the endpoint quicker than anticipated in the protocol","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was prematurely terminated because of slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was prematurely terminated due to slow enrollment beyond the planned study timelines.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was prematurely terminated, due to difficulties in the recruitment of T2DM patients who are not under statin therapy at inclusion.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was started before the official request for protocol registration","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped because of safety concerns","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped by the sponsor based on a non-safety related business priority decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped by the sponsor based on a non-safety related business priority decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped due to a non-clinical safety finding.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped due to business\/operational issues.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped due to lack of adequate enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped due to low enrollment.","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped due to low subject enrollment. No safety issue or other concern factored into this decision.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped due to poor accrual and lack of funding.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped due to safety concerns","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped due to slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped due to time constraints and resources","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped early due to slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped early due to slow enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped early for futility reasons.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped on november 2006 after inclusion was fulfilled","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped prematurally due to low recruiting","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped prematurely due to insufficient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped since the superiority of intravenous omeprazole to ranitidine has already been proven by recent other studies.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was stopped, as the another multicentre-RCT on the same patients started.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was suspended due to COVID-19 cessation of research activities in March of 2020","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was suspended in order to perform an interim analysis.","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was targeted to accrue 130 patients, but closed early for futility.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terimnated - low rate of cases","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated after Merck Serono had taken the decision not to pursue the development of AS900672-enriched in Ovulation Induction","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated after a pre-planned futility analyses showed an insufficient level of\u00ca efficacy in the study population to warrant continuation.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated after the EMEA recommended to suspend the marketing authorisation of Raptiva in the EU","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated after the planned interim analysis.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated as other related studies of ruxolitinib did not provide sufficient\u00ca efficacy to warrant continuation.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated as the Prinicipal Investigator left the site- all previous subjects \u00ca enrolled are deceased","label_descriptions":["Study_Staff_Moved","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"The study was terminated based on a non-safety related corporate decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated based on a recommendation of the DSMB following the identification of two patients with significant elevations in serum transaminases","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated based on the recommendation by the DSMB following a pre-planned protocol interim analysis because the endpoint was not achieved.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated because BioMarin decided to end the overall development program based\u00ca on competing corporate priorities.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated because it is very difficult to recruit more patients.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated because it was not enrolling at the expected rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated because of Early Treatment Failure in child.The justification for this decision are concerns about safety of children.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated because of an inability to enroll.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated because of recruitment challenges","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated before reaching its accrual goal due to slow accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated by the Sponsor for administrative reasons and not due to any safety\u00ca concerns.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated by the sponser due to low study enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to a change in sponsor prioritization.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to a considerably lower recruitment rate than anticipated","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to difficulties with finding sites and subjects willing to participate.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to hepatoxicity of compound","label_descriptions":["Study_Design","Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to lack of efficacy in Cohorts 1 and 2.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to low accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to low enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to low enrollment. This resulted in the study being underpowered\u00ca and inconclusive.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to poor accrual after enrolling 62 of planned 300 patients in 20 months.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to poor enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to poor feasibility and lack of interest at the participating\u00ca sites.","label_descriptions":["Business_Administrative","Study_Design"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to results in another study (NCT00878501).","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to slow accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to the inability to enroll subjects.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated due to too slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated early because there were other competing protocols.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated early due to company decision (non-safety related).","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated early due to enrollment challenges.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated early due to lackluster pharmacodynamic data that showed no\u00ca significant reduction of plasma kynurenine at steady state of M4112.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated early due to low accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated early due to poor recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated early due to poor subject enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated in the interest of patient safety.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated on August 6, 2012, because 2 large Phase 3 studies showed no clinical\u00ca benefit. This decision was not based on any new safety concerns.","label_descriptions":["Another_Study","Negative"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated on June 22, 2007 for inability to enroll patients within an appropriate timeframe. There were no efficacy\/safety concerns.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated on June 24th, 2015 due to change in strategy of PF-03084014\u00ca development. There were no safety\/efficacy concerns behind the decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated on June 25th, 2009 due to strategic decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated on June 25th, 2009 due to strategic decision\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated on the basis of futility. There were no safety or toleration issues.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated prior to completion to focus on the development of a controlled release formulation.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated prior to enrolling patients as we were unable to secure enough \u00ca funding to complete the study.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was terminated upon completion of escalation phase, prior to opening expansion\u00ca cohorts","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was withdrawn due to lack of an appropriate patient population. No screened patients met inclusion and exclusion criteria.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The study was withdrawn prior to IRB approval.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The supplies of study drug were halted by Gilead Sciences Ltd.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The target cannot be achieved within timeline due to delay of ethics approval","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The target drug, dovitinib, failed as a single agent in prior studies in patients with heavily \u00ca treated multiple myeloma.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The termination of the study is not linked to a product recall or result of any safety signal. Rather it was sponsor's commercial decision to withdraw the MA","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The tested combination was ineffective.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The total number of patients has been reached.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trail end was achived according to the definition in the trial protocol","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial end was achieved according to the definition in the trial protocol","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial ended.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial experienced recall of rescue medication provided by an US vendor. Limited availability of alternative rescue medication severly impacted timelines","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial has been terminated due to an estimated low probability of clinical benefit based on\u00ca limited anti-leukemic effects observed in safety run-in (Part 1)","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial has been terminated per Sponsor direction due to longer than expected clinical and\u00ca regulatory approvals.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial was ended per sponsor due to slow accrual rates.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial was stopped at the first stage due to futility","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial was stopped based on information from the global phase 3 studies.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial was stopped earlier than planned because of the slow accrual rate.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial was terminated because of deviations from the protocol.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial was terminated because of difficulties in recruitement.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial was terminated due to insufficient enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial was terminated due to investigator's decision","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial was terminated due to lack of compliance with GCP regulations.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"The trial was terminated on May 2008 after inclusion of 10 patients due to low recruitment and patient compliance.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"The whole project was terminated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"There are not enough patients enrolled.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"There could not be enough patients recruited","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"There is no funding to proceed.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"There is no participant enrolled in this study since developing this trial and other cholangiographic techniques are more available in our institute.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"There is no possibility to reach the target patient number within the set time frame","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"There was a problem with funding and with the acquisition of the lab assays","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"There was no funding for the device to be used in the study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"There were no subjects enrolled locally on this study since it opened. Local IRB closure has\u00ca been requested.","label_descriptions":["Insufficient_Enrollment","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"There were no subjects ever enrolled. Study was closed at the IRB.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"There were not enough eligible families and trained clinicians to conduct RCT.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Third dose group not recruited due to slow enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This action was a business decision & not related to any efficacy, safety or clinical concerns\u00ca with lesinurad.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This condition can now be managed in the office with an injection of Lucentis.","label_descriptions":["Study_Design","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"This decision was made based on the slow recruitment and high discontinuation rates in the study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This is due to the safety risk of the COVID 19 virus to the healthy volunteers and the fact","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This pivotal trial and one conducted in Europe did not meet the primary efficacy endpoint for the double blind phase.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This program was terminated for financial reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This project was not funded.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This protocol was replaced with a different one and therefore discontinued.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"This protocol was terminated not for safety reasons, but because Pfizer decided to return the worldwide rights for Exubera to Nektar, on 18 October 2007.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study did not receive funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been cancelled as the esreboxetine development program is being discontinued. Safety and efficacy were not factors.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been cancelled prior to enrollment.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been placed on clinical hold by the sponsor due to operational reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been suspended due to COVID-19 Virus pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been terminated because of insufficient patient recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been terminated early as the esreboxetine development program is being discontinued. There are no safety or efficacy concerns.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been terminated for administrative reasons only.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been terminated. (Interim analysis of preliminary results indicated the need\u00ca for protocol re-design).","label_descriptions":["Study_Design","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been transfered from a sponsored trial to an investigator initiated trial.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been withdraw from the IRB. The PI has transferred to another university. The IND was transferred.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"This study has been withdrawn because the drug would not meet trial criteria for efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been withdrawn prior to enrollment.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has been withdrawn prior to recruitment.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study has closed to accrual early due to slow accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study is being discontinued based on data suggesting that none of the doses tested demonstrated both glycemic &amp; body fluid benefits vs. the comparitor","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study is not an applicable clinical trial.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study is temporarily suspended due to COVID-19 pandemic.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study is terminated as a result of data from a study that showed increased mortality in stroke patients.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study not get the approval by the drug company","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study put on inactive status due to no identifiable subjects to enter the protocol.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study terminated 27Apr2010 due to slow recruitment and the need to use the existing\u00ca information to determine dosing for another study.","label_descriptions":["Insufficient_Enrollment","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was Cancelled Before Active","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was cancelled due to lack of enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was closed due to lack of funding.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was for National Science Council project. The study was not funded, so the study was withdrawn.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was halted prior to enrolling.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was not activated, no data was collected.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was not conducted as the Principal Investigator left the institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"This study was prematurely terminated (26 June 2009) due to slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped 29OCT2009 due to strategic drug development considerations","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped 29OCT2009 due to strategic drug development considerations.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped as no patient asked to participate was prepared to do so","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped because of an inadequate rate of enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped because of insufficient enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped by the sponsor based on a non-safety related corporate decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped by the sponsor before enrollment based on a non-safety related corporate decision.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped due to insufficient recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped due to poor enrollment numbers","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped due to slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped due to slow enrollment after enrolling 25 of 200 patients.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped due to slow enrollment after enrolling only 12 of 80 patients over 14 months time.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped due to slow enrollment after enrolling only 9 of 80 patients over 14 months time.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped early due to slow enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped for slow enrollment after enrolling only 11 of 180 patients in six months time.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped for slow enrollment after enrolling only 11 of 180 patients in six \u00ca months time.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped prematurely due to lack of efficacy.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was stopped to allow initiation of a mult-center study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was suspended due to insufficient subject accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was suspended for futility","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was temporarily paused due to an unanticipated bioanalytical issue.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated May 7, 2007. The study stopped due to tablet formulation issues. No safety issues were involved in the termination decision.\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated at the recommendation of an independent Data Monitoring Committee. The decision was not based on any safety concerns.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated at the request of the drug manufacturer.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated based on preliminary safety data.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated because it was unlikely to have sufficient power to show a difference with therapy on an interim analysis.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated because of recruitment difficulties.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated because the drug company stopped making the study drug","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated due to low accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated due to low enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated due to poor enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated due to slow enrollment, despite protocol amendments to change the entrance criteria.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated due to slow enrollment, despite protocol amendments to change the \u00ca entrance criteria.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated early as a result of regulatory action suspending tegaserod use in 2007","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated early due to lack of adequate enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated early due to poor recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated early due to poor recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated early due to slow enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated early in April 2005 due to low patient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated early in May 2006 due to low patient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated for administrative reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated for administrative reasons. The dose ranging plan for the program was revised.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated in November 2008 due to &quot;a business decision (resources)&quot;.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated on January 6, 2010, due to toxicology findings in animals exposed to \u00ca PF-04455242 for three months.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated on November 20, 2003 because of poor recruitment. This study was not terminated due to safety\/efficacy.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was terminated. An IT injection study of C. novyi-NT in patients with treatment\u00ca refractory solid tumor malignancies may be viewed at NCT01924689.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was withdrawn due to business reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was withdrawn due to lack of necessary resources from the liver transplant surgical\u00ca group.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was withdrawn due to study agent availability.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was withdrawn for administrative reasons. The dose ranging plan for the program was revised&quot;.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was withdrawn for administrative reasons. There were no safety concerns.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was withdrawn for business reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study was withdrawn prior to patient enrollment","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study will not be conducted. A new study is replacing this one.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This study will not be initiated. Study will be conducted with Systane Ultra in 2010.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"This study will undergo a temporarily pause in recruitment (screening and enrollment) due to\u00ca the COVID-19 pandemic.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This trial discontinued on 2 May 2008 due to lack of enrolment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This trial discontinued on 20 JUN 2008 because the interim immunogenicity results do not justify these formulations as pandemic vaccine candidates","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This trial discontinued on 30 JUN 2006 due to a lack of enrolment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This trial is being closed based on lack of substantive efficacy, slow accrual and overall tolerance in patients treated to date.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This trial is being closed based on lack of substantive efficacy, slow accrual and overall\u00ca tolerance in patients treated to date.","label_descriptions":["Insufficient_Enrollment","Safety_Sideeffects","Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This trial was never initiated due to inability to obtain the device","label_descriptions":["Logistics_Resources","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This trial was supporting the development of an asset which was terminated, thus the data from\u00ca the study were no longer required.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This was a follow-on study to Biomed 777-CLP-029 which did not meet superiority endpoint","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"This was an inpatient study, but PI left inpatient service at MGH","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Tightly defined inclusion criteria were making recruitment very slow.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Time constraints","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Time to engraftment would not be improved compared to historical controls.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"To conserve remaining capital, Sponsor decided to terminate the study early.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"To difficult to recruit patients in the acute setting","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"To few included patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"To focus on another clinical indication.","label_descriptions":["Business_Administrative","Another_Study"],"Another_Study":true,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"To many infants in the experimental group developed hypertriglyceridemia","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"To pursue other indications","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Too few inclusions","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Too few patients completed the study once enrolled.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Too frequent grade 3-4 toxicities","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Too much cross over bias between small numbers of participants","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Transferred study sponsor","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Transitioned into a national study through ECOG","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Treatment ineffective","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Treatment strategy changed","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Treatment with thymic shielding found safe, another study started.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial cancelled","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial completed prematurely.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial discontinued due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial is currently suspended to enrollment by study sponsor due to slow accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial prematurely discontinued due to slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial put on hold due to COVID 19 pandemic. This is a first-in-human trial and safety","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial stopped June 2007","label_descriptions":["No_Context","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial stopped early for futility","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial stopped for administrative reasons prior to official determination of MTD.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial suspended on 26 February, following the publication of a trial with negative results (Ann Intern Med 146(4), 2007). Pending ethics committee re-approval.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial temporarily suspended until additional funding can be secured","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial terminated (recruitment delays)","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial terminated after recruiting 172 patients but without proceeding to the highest dosing cohort as this no longer reflects common clinical practice","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial terminated after recruiting 172 patients but without proceeding to the highest dosing\u00ca cohort as this no longer reflects common clinical practice","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial terminated due to financial resource limitations","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial terminated prematurely due to slow recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial was rewritten and will no longer focus on the link between smoking and depression.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial was stopped due to difficult enrolment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial was stopped due to slow recruitment. There were no safety concerns in the trial.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial was stopped early due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial was stopped early due to low enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial was terminated due to the impact of the COVID-19 on trial activities. 68 patients with","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial was terminated due to the need to re-formulate the study drug.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial was withdrawn for drug availability issues.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Trial will not meet CTEP Early Phase Trial Slow Accrual Guidelines","label_descriptions":["Study_Design","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Two participants enrolled, both inevaluable.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Two patients in the first dose level be counted as reaching DLT. DSMB recommend terminated\u00ca early this trial.","label_descriptions":["Safety_Sideeffects","Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"UACC-PHX is no longer able to support the study and Novartis is unable to provide drug beyond\u00ca December 2019.","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to accrue patients to the study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to accrue subjects to the study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to complete a contract with the Sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to complete due to lack of funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to complete enrollment due lack of family interest.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to complete study","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to determine the optimum tolerated dose","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to enrol enough people to achieve the full sample size","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to enroll","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to enroll any patients in the study due to other on-going studies.","label_descriptions":["Logistics_Resources","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to enroll into study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to enroll subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to keep patients attending yoga sessions","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to meet enrollment number to complete study, study stopped June 30, 2007\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to meet enrollment numbers","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to meet recruitment and enrollment goals","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to meet subject enrollment goal.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to obtain approval from FDA for use of chloral hydrate","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to obtain funding to complete study never started study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to put forth the human resources for patient enrollment","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to reach accrual target.","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to reach the target recruitment within timeline","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit adaquate number of GHB dependent subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit any subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit any subjects for this study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit enough patients to continue on with the study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit enough subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit enough subjects to attain the minimum sample size.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit into the study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit large enough sample; large expectancy effects; No adverse events recorded; results uninformative with respect to efficacy","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit necessary sample size","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit participants.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit subjects in the Turkey site.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit subjects into the trial.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit sufficient numbers of patients.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to recruit target enrollment numbers","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to renegotiate an expired contract w\/sponsor providing study med","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to secure supply of the study medication","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unable to successfully recruit subjects to this study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unacceptable Neurotoxicity (2 cases)","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unacceptable incidence of wound dehiscence in the PDS group","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unavailability of clarithromycin 250 mg in the market","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unavailability of investigational product","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unavailability of study article","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unavailable study resources","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Under additional IRB Review","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Undergoing interim analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unexpected adverse event","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unexpected difficult recruitment. Study drug expired","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unexpected safety events.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unexpected side-effects: reversible and mild to moderate neurological impairment","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unexpected withdrawal of funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unexpectedely high rates of treatment-failure","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unfavourable Pharmakokinetics","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unforeseen difficulty identifying and enrolling eligible subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unfortunately we had unforeseen difficulty recruiting to this study. Therefore we have decided to halt the study and not publish the results.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unfortunately, other Phase III clinical Study (GEM+S-1 vs GEM vs S-1) have been started in Japan.\"","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"UniQure, has decided not to renew the Marketing Authorization of Glybera in the EU. This\u00ca decision is not related to any safety, efficacy or quality issue","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unknown","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unplanned interim analysis by DSMB indicated possible reduced response rate with the addition of Ca\/Mg in pooled population. Further analysis pending.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unrelated serious adverse events involving one of the proposed medications","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unsatisfactory enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unsatisfactory filter deployment in several cases","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unsuccessful recruitment","label_descriptions":["Insufficient_Enrollment","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Unsufficient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unsufficient referrals for recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Unusual high frequency of elevated liver function tests.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Urgent shift among clinical sites toward efforts to combat COVID-19 pandemic;impacted","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Varience of supply chain from that required by protocol","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Ventricular rate during AF in CRT-patients much lower than expected","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Very difficult to recruit patients\/slow recruitment(2 patients in nearly 2 years).","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Very low rate of recruitment anticipated futility of pursuing the study","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Very low recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Very low recruitment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Very poor enrollment","label_descriptions":["Insufficient_Enrollment","Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Very poor recruitment in the Part 4 of the study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Very poor recruitment of patients to the study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Very slow enrollment.Study entry criteria not in line w\/local standards of care","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Voluntarily closed and terminated by the PI due to lack of feasibility","label_descriptions":["Logistics_Resources","Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Voluntarily terminated based on preliminary non-clinical findings.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Voluntary halt of further dosing due to an FDA Clinical Hold issued in relation to Dynavax study DV2-HBV-10","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Voluntary suspension due to substantial study updates and COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Waiting for FDA approval of IND","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Was not able to recruit enough patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Was unable to accrue any patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We are awaiting publication of the Erythropoietin in Acute Ischemic Stroke Study(NCT00604630).","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We believe regional anesth better for TKR,90% patients got epidural. Last year we started spinal morphine one shot, and found it very promissing.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We can't obtained the test drug (Vadenafil) from Bayer. They decided not to carry out this trail in Taiwan. Therefore this trail has never been started.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We closed the study to further enrollment based on the lack of perceived need for domperidone in this population.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We could not get funding for study.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We could not receive the support from the national medical insurance owing to the changed\u00ca policy of the government for clincal trials.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We decided that the study would not substantially add to existing contributions in the literature","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We decided to enroll patients via e-mail rather than via telephone and are waiting for the hospital registration system to be updated with patients' e-mail.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We determined that the results would not be worth reporting.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We did not achieve a tolerogenic profile. Subjects withdrew from protocol and enrolled in\u00ca other islet transplant trials.","label_descriptions":["Study_Design","Insufficient_Enrollment","Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"We did not see any effect of Palifermin on benign or malignant tumor growth","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We didn't use this tech in patient.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We didnt recieved the medicine","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We encounter technical problems to continue with the study. (Notably difficulty in teaching the patients to use the dressing set involved in the study.)","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We failed to recruit patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We found out that there is another study on the same issue","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We had got enough data, therefore we stopped the study and published the data.\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We had to suspend our clinical trials due to the pandemic of COVID-19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We have decided to cancel this study.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We have recruited 16 subjects for the pilot study. The recruitment will resume once the amendments are approved for increasing sample size to 30 subjects.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"We need to make significant adjustments to proposed drug and its delivery method","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"We strongly feel that the ability to recruit the required number of patients is very low and\u00ca thus decided to stop the study.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We were unable to enroll a sufficient number of patients due to manpower.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We were unable to procure the supplement for this study.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We were unable to receive IVIG free from phamaceutical company.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We were unable to recruit sufficient patients within the confines of our budget","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"We wish to wait until there is more data available using this substance.","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"When 9 subjects of targeted 12 subjects had been studied, no changes in plasma potassium were detected and it was deemed futile to continue with enrolment.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"When used appear DNE3 toxic properties. The DSMB determined that due to higher than expected \u00ca risk and safety concerns the study should be closed.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"While the GBT440 IPF results noted an improvement in oxygen saturation, they did not translate\u00ca into a clinically meaningful benefit.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Will study new T-cell construct for the same indication","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawal of drug supply.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawal of marketing autorization of efalizumab by the EMEA.","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawal of pharmaceutical company support for the investigational drug","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawal of pharmaceutical support from Novartis","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn (No Participants Enrolled)","label_descriptions":["Study_Design","Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn - due to lack of accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn as NCI rescinded approval for parent study NSABP-B-45","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn as company has shut down and filed for bankruptcy","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn as early analysis indicated stereotactic radiosurgery not as beneficial post-op as pre-op","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn as study has been abandoned","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn as study never opened","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn as the clinical development of ATN-224 was terminated by the drug company who was providing ATN-224 for the study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn as the sponsor has stopped the drug for NSCLC population","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn as trial was never activated by SuperGen","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn as was replaced by another study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn because Ablatherm devices were not available anymore at trial centers","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn because of lack of aprovement from local medical authorities","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn because of personal ressources before inclusion of the first patient","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn because protocol has been discontinued. It was never opened.","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn because study never opened to accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn because there were no dramatic changes in the main endpoint, as well as low enrollment numbers. The data are not interpretable in terms of efficacy.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn because treatment guidelines changed","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn by PI","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn by sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn by the study sponsor.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to &quot;toxicity&quot; problems","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to an excess of toxic deaths","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to contractual issues","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to drug availability and funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to drug toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to failure to meet primary endpoint","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to funding, interest, and accrual problems\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to inability to reach an acceptable agreement with industry sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to lack of accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to lack of drug supply","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to lack of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to lack of enrollment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to lack of study participants","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to low accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to low accrual. No data analyzed.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to medication withdrawal from the EMEA","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to no accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to poor accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to poor accrual and lack of feasibility","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to poor accrual\/lack of funding","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to poor\/low accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to slow accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn due to transfer of Investigator","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"Withdrawn for administrative reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn for lack of funding and accrual","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn for poor accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn for problem of logistics with the associated laboratories","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn in October 2006, no longer of interest\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn pending further review of clinical design.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn per Bayer","label_descriptions":["Business_Administrative","Logistics_Resources"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn per sponsor and Investigator","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn prior to recruitment for business reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn. Unable to set up appropriate infrastructure to support study.","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn: Study halted prior to enrollment of first participant","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrawn: study halted prematurely, prior to enrollment of first participant\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrew due to funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Withdrew the IND with the FDA.","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Zero accrual and failure to generate multicenter interest.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"Zn released from vehicle led to fortification levels higher than planned. New filter will be\u00ca developed.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"a lack of a potential patient.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"accrual goal met","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"accrual rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"accrual temporarily suspended during COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"additional enrolment criteria made patients' recruitment not feasible anymore","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"administrative reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"adverse events related to drug lot","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"all patients recruited","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"all patients required included","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"as of 4\/23\/97","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"ation (Ghezel-Ahmadi. Thorac Cardiovasc Surg. 2014 Nov 21)","label_descriptions":["No_Context"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":true,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"awaiting IRB approval on amendment change regarding dose reductions","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"awaiting additional funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"awaiting amendment approval","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"based on interim analysis statistical significance in primary endpoint cannot be achieved with planned sample size, no safety concerns\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"because in a preliminary analysis we would need 1000 patients per group to achieve significative differences in the main end point.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"because of lack of funding and recruitment problems the study has been closed.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"because of the presence of unexpected administrative barrier to interfere the collection of case","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"because of unexpected administrative barrier, it was very difficult to enroll case.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"business reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"cancelled before enrollment","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"change in development plan, not due to safety concerns.\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"change in donor site care protocol; donor site healing is a study endpoint","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"change of study population and chemotherapeutic regimen","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"closed by sponser","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"closed due to slow accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"closed due to toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"closed to accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"closed to enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"company focus on other projects","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"competitor study about to start","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"conduct (recruitment) not feasible within timeframe","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"conflicting study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"contract issues","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"could not find subject population","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"couldn't recruit patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"data collection completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"data collection ended","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"data collection sufficient","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"decision made not to proceed -- no subjects were ever enrolled","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"decision to stop the study because of enrollment difficulties.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"decreasing rate of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"development of product discontinued","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficult enrollment after the primary investigator left the centre","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficult to enroll subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficult to recruit subject","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulties by enrolling patients fundings consumed, no staff could be recruited and payed to continue enrolling patients,\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulties for including diabetic patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulty in achieving target enrollment numbers","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulty in patients's inclusion","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulty in recruiting patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulty in recruiting subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulty in recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulty obtaining required data","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulty of enrolling patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulty of recrutement","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulty to include patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"difficulty with accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"drug not available","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"drug withdrawn from market","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"drug-related harm","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to COVID-19 (at least until 25 APRIL 2020)","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to COVID-19 restrictions","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to celecoxib safety issues","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to lack of finance","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to low study enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to multiple subjects reporting pain and burning at the phlebotomy sites after 38hr","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to poor enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to recruitment problems \/ based on recommendation of Independent Review Board","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to slow recruitment of patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to strong side effect","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"due to very low recruitment. For this reason, there will be no further analysis and reporting of this study.\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"during Period 1 due to numerous orthostatic AEs that occurred. Subsequently, RLD was reduced to 5 mg due to safety concerns.\"","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"early termination due to loss of interest and low enrollment of patient","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"early termination due to slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"echo contrast agents no longer allowed in CAD patients.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"end of the follow-up period","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"enough patients have been enrolled for the statistic analysis","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"enrolling participants stopped","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"enrollment completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"enrollment criteria not met by PI patient population","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"enrollment difficult due to inclusion\/exclusion criteria\/protocol requirements","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"enrollment insufficient: lack of motivated patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"enrollment stopped for safety issues","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"enrollment was completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"exhausted personel after a long recruiting period","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"extremely slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"failed recruitment efforts","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"failure of recruiting a sufficient number of patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"failure to accrue","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"feasibility and low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"feasibility issues","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"financial reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"financial support withdrawn","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"following DSMB recommandation.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"for administrative reasons","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"for lack of recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"four adverse events encountered","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"funding exhausted","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"funding was withdrawn","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"funding was withdrawn from Drug company","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"funding withdrawn","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"futility","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"ganaxolone did not significantly reduce spasms after an 8-day placebo control period","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"grant funding ended and lack of sufficient participants to complete trial","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"grant was not approved.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"higher incidence of pain related sexual dysfunction in the TO arm","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"images obtained were non-diagnostic","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"immunohistochemistry markers are not recieved yet","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"inability to recruit due to administrative difficulties at the site","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"inactive","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"inadequate enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"inadequate number of enrolled study subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"inadequate recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"inclusion was finished","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"inconclusive results, market feasiblity\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"insufficent enrolement","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"insufficient enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"insufficient enrollment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"insufficient enrolment","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"insufficient funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"insufficient number of eligible subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"insufficient numbers of eligible patients as laparscopic surgery increased and open surgery decreased.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"insufficient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"insufficient recruitment\/enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"interim analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"interim analysis found no difference in LB rate and lower than expected event rate","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"interim analysis indicates statistical futility for primary outcomes","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"interim analysis showed significant differences between two treatment groups","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"interim analysis suggested no differences with whole sample","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"interim review of the data indicated that the hypothesis put forth on the efficacy of a 3 day regimen was not met.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"intermediate analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"investigation of adverse events","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"investigation of adverse events in a related clinical study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"investigator closed study","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"is finish","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"it was not possible to recruit any patient in the study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"it was not possible to recruit new patients anymore","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"key investigator relocated.","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"key personnel left institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"key study staff left foundation","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"lack of accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of appropriate funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of data","label_descriptions":["Insufficient_Data"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":true,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of effectiveness","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of efficacy (intermediate analysis)","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of efficacy and tolerability","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of efficacy of the prednisone\/placebo","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of eligible patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of enrolment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of new patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of participants fulfilling inclusion criteria","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of patient population - slow accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of pharmaceutical support","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of recrutment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lack of study personel","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lacking recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"logistic reasons, patients could not be recruited\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lost funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low accrual; loss of funding","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low enrollling","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low enrolment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low patient accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low patient number after 2 years recruiting","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low patient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low recruitment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"low response rate, no evidence of PFS or OS improved.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lower than anticipated accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"lower than expected enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"machine used to measure indiret calorimetry is broken, new machine on order\"","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"manufacturer could not finance the study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"negative outcome","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"never started","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no METC approval obtained","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no actual patients recruited within year 1 after ethical committee approval","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no change in primary endpoint at week 48","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no eligible patient","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no eligible patients can be found","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no fund","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no longer interest from medical community","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no patient recruiting","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no patient recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no patient was recruited till 1\/2008","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no patients could be recruited","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no patients recruited, responsible physician left clinic\"","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"no recruited patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no research staff and funding support","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"no resources available","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"non-enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"not appropriate to carry on the study","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"not enough enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"not enough patients meeting inclusion criteria","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"not enough patients to e recruited, problems with the conductance catheter\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"not funded","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"not known","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"not progressing as anticipated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"notification from sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"only one patient enrolled","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"only recruitment temporarily paused due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"opposite result","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"patel no longer at pittsburgh","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"patient's recruitment too difficult","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"patients with inflammatory colitis not included","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"patients with neurological disease not included","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"pending enhancements to protocol","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"per Data Monitoring Committee recommendation","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"performance variability","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"personnel shortage","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"planned to design a prospective study","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"poor accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"poor accrual and response less than expected on interim analysis","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"poor enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"poor enrolment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"poor patient recrutment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"poor recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"poor recruitment, pilot outcome measures inappropriate\"","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"positive results from a larger study with same regimen was released.","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"post-surgical complications in the last 2 patients","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"potential harm of insulin infusion outweights the benefit.","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"prematurely terminated due to loss of interest","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"primary efficacy analysis at Week 24 did not demonstrate non-inferiority of raltegravir versus lopinavir (+) ritonavir","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"primary efficacy endpoint not attainable.","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"primary site withdrew due to competing study: never enrolled any subjects.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"principal Investigator left institution","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"principle investigator moved, new investigators will join, insurance expired - project needs to be re-examined by an ethic committee\"","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"problem of accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"problems in funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"problems with including patients and a large multicenter Trial is now starting as follow-up","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"procedure no longer being done","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"program discontinued based on GIPF-007 results","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"project was only internally funded and would complete for subjects with 2 newer externally funded projects","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"proof of mechanism achieved with fewer subjects than anticipated","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"protocol changed and a new study using verapamil in epilepsy will be started in the near future","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"protocol development and Amended protocol revision","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"protocol needs complete restructuring in order to make it feasible and to complete the enrollment of 23 patients","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"protocol not approved by VA R&amp;D","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"protocol revisions were deemed unable to be completed by 8\/2007","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"protocol violation","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"prototype catheter never delivered","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"questions of the benefit efficacy\/risks of ddI during the meal not resolved","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"rate of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"reaching of step 1 (recruitment of 8 patients) per protocol -&gt; risk assessment -&gt; termination because of occurance of toxicity Grade 3 and 4","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recommendation from the IDMC (Independent Data Monitoring Committee)","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recommended by DSMB due to lack of accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruiting or enrolling participants has halted prematurely and will not resume","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruiting or enrolling participants has halted prematurely and will not resume; participants are no longer being examined or treated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruiting or enrolling participants has halted prematurely but potentially will resume","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruiting problems","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment failed","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment failure","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment goals met","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment has been put on hold until a future date","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment has ended","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment is finished","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment issues","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment of subjects was halted prematurely. recruiting subjects halted prematurely","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment on hold due to COVID risk","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment recruitment recruitment recruitment difficulties","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment temporarily suspended due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"recruitment was stopped as consequence of cessation of funding (economic crisis)","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"reports indicating that increased folic acid intake may increase colin cancer","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"research priority change","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"response to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"results did not show intervention was beneficial","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"run out of independent funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"safety concerns regarding use of rosiglitazone","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"safety issues (toxicity)","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"safety reasons","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"side effect profile did not match expectations","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"significant reduction in length of hospital stay (primary endpoint)","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"similar large study planned by NHLBI","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow a accrul due to many competitive trials.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow accrual and financial resource limitation","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow accrual for Cohort II","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow enrollment , interim analysis conducted.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow enrollment and change in product development strategy","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow recruitment and treatments beyond expiry date","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow recruitment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"slow subject recruitment and lack of medical and scientific merit due to change in new standard of therapy during that same period.","label_descriptions":["Study_Design"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":true,"Study_Staff_Moved":false,"Success":false}
{"text":"sponsor decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"sponsor funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"sponsor has decide to pospone this study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"sponsor's decision","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"staffing changes","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"stopped after planned interim analysis for lack of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"stopped due to slow recruitment and no effect","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"stopped for lack of efficacy","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study closed to accrual due to slow accrual","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study closed to enrollment 04\/07\/2005 due to two large phase III trials showing no survival benefit of combining bexarotene with platinum-based chemotherapy","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study completed","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study drug unavailable","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study lacked funding to recruit","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study moved to alternate site","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"study no longer at pittsburgh","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}
{"text":"study recruitment temporarily on hold","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study suspended due to staff indisposition","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study terminated 12Feb09 due to low recruitment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study terminated due to lack of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study was cancelled","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study was never started due to regional geopolitical conflict","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study was not ethically acceptable to continue and therefore it was finally stopped","label_descriptions":["Ethical_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":true,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study was originally suspended by sponsor; now sponsor has approved; study still suspended until modification is submitted and approved by IRB","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study was suspended because of difficluty maintaining equipment","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"study withdrawn due to lack of enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"subject enrollment goals not met","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"sufficient data collected","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"sufficient data collected for significant conclusive results","label_descriptions":["Endpoint_Met"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":true,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"sufficient number to reach the primary endpoint and as planned","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"survival advantage demonstrated","label_descriptions":["Success"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":true}
{"text":"suspended pending data analysis","label_descriptions":["Interim_Analysis"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":true,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"suspended to recruiting due to COVID-19","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"suspended we do not received authorization for Triacetin from Health Authorities","label_descriptions":["Regulatory"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":true,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"technical difficulties coordinating study","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"temporarily closed (paused to accrual)","label_descriptions":["Insufficient_Enrollment","Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated because of enough case number","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated by PI","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated due to administrative reasons.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated due to corporate transaction.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated due to inability to recruit subjects","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated due to lack of accrual.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated due to slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated due to very low recruitment rate (27 June 2006)","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated for logistical reasons","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated study","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated, due to lack enrollment,\"","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"terminated, end of the study\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"termination due to futility (very slow patient enrollment)","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"test drug showed lack of benefit at interim analysis","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"that there is not data on coinfections of malaria and COVID 19.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the COVID-19 pandemic.","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the company does not want toproceed yet with the study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the number of patients will be included is reach","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the study has concluded normally;","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the study has recently ended, all information gathred as planed\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the study is publiched","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the study is withdrawn due to low and unexpected enrollment rate","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the study stopped because we could not recruit enough patients.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the study stopped becaust the sponsor did not wish to proceede with the study","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the study was early terminated due to lack of recruitment.","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the study was halted after the first interim analysis as there were significantly more patients who recovered at one month in the control arm","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"the study was terminated because of slow enrollment","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"there is a problem in recruting the paricipents","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"this study was suspended for futility","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"to the COVID-19 pandemic","label_descriptions":["Covid19"],"Another_Study":false,"Business_Administrative":false,"Covid19":true,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"too few patients included","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"toxicities required dose reduction compromising effectiveness","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"trial stopped on Sept 24, 2007\"","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to enroll","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to enroll patient population","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to enroll subjects into the study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to find subjects meeting inclusion criteria","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to obtain contract with sponsor","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to obtain funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to recruit","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to recruit patients","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to recruit patients for study","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to secure additional funding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unable to secure funding for analysis of laboratory data.","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"underfunding","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unexpected level of toxicity","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unknown","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"unsatisfactory efficacy data from preceding trial","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"very slow recruitment and treatments beyond expiry date","label_descriptions":["Insufficient_Enrollment"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":true,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"voluntarily by Sponsor to investigate an anticipated SAE","label_descriptions":["Safety_Sideeffects"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":true,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"was replaced by an other study","label_descriptions":["Another_Study"],"Another_Study":true,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"was terminated due to meeting a priori stopping rule set by DSMB","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"we decided not to go on treatment phase","label_descriptions":["Invalid_Reason"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":true,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"we didnt recieved the medicine","label_descriptions":["Logistics_Resources"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":true,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"we have seen little, if any, improved benefit of using 577 as opposed to 595 nm.\"","label_descriptions":["Negative"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":true,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"withdrawn due to contractual issues","label_descriptions":["Business_Administrative"],"Another_Study":false,"Business_Administrative":true,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":false,"Success":false}
{"text":"withdrawn due to non-response. PI left university","label_descriptions":["Study_Staff_Moved"],"Another_Study":false,"Business_Administrative":false,"Covid19":false,"Endpoint_Met":false,"Ethical_Reason":false,"Insufficient_Data":false,"Insufficient_Enrollment":false,"Interim_Analysis":false,"Invalid_Reason":false,"Logistics_Resources":false,"Negative":false,"No_Context":false,"Regulatory":false,"Safety_Sideeffects":false,"Study_Design":false,"Study_Staff_Moved":true,"Success":false}