Lok Sabha Question No. 2910 (UNSTARRED), answered on 2021-12-15
Subject: Funds for Research & Development
Ministry: SCIENCE AND TECHNOLOGY
Asked by: S. Gnanathiraviam

- (a) Yes Sir.
- (b)  &  (c) Details  of  the  R&D  projects  and  funds  sanctioned  by  the  Department  of Biotechnology  along  with  its  PSU,  Biotechnology  Industry  Research  Assistance  Council (BIRAC) in the state of Tamil Nadu and other States in the current financial year may please be seen at Annexure A and B respectively .

****

## GOVERNMENT OF INDIA

## MINISTRY OF SCIENCE AND TECHNOLOGY DEPARTMENT OF BIOTECHNOLOGY

## LOK SABHA UNSTARRED QUESTION NO. 2910 TO BE ANSWERED ON 15.12.2021

## FUNDS FOR RESEARCH & DEVELOPMENT

2910. SHRI GNANATHIRAVIAM S.:

Will the Minister of SCIENCE AND TECHNOLOGY

िवǒान और ŮौȨोिगकी मंũी

be pleased to state:

- (a) whether the department of bio-technology has been allocating funds for research and development to universities, colleges and NGO's in the state of Tamil Nadu and other States;
- (b) if so, the details thereof; and
- (c) the details of the funds and projects sanctioned by the department for the purpose?

## ANSWER

## MINISTER OF STATE (INDEPENDENT CHARGE) OF SCIENCE AND TECHNOLOGY AND EARTH SCIENCES

(DR. JITENDRA SINGH)

## ANNEXURE A

## 1. R&D Projects sanctioned by DBT in Tamil Nadu

|   S. No. | Name of project                                                                                                                                                                                                                 |   Sanctioned amount (in Rs. lakhs) |
|----------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|------------------------------------|
|        1 | Generation and Characterization of Chicken Egg Yolk Antibodies (IgY) for Passive Therapy against Clarithromycin Resistant Helicobacter pylori and its Preclinical Evaluation in a Suitable Animal Model                         |                            28.768  |
|        2 | Cold active lipase from Pseudomonas sp. and its utilization in the enrichment of ?-3 poly unsaturated fatty acids (PUFAs) in plant and fish oils                                                                                |                            35.3682 |
|        3 | Are fusion inhibitors potential pan-coronavirus therapeutic agent?                                                                                                                                                              |                            52.677  |
|        4 | Solid state fermentation technology for development of cost effective customized plant protein products as fishmeal alternate for shrimp feed                                                                                   |                            72.7672 |
|        5 | Recombinant Probiotic-mediated targeted delivery of CRISPR/Cas13 for the treatment of SARS CoV-2 viral infection                                                                                                                |                            41.02   |
|        6 | Role of wild type and disease-relevant mutant LRRC8B proteins in ER stress related signaling                                                                                                                                    |                            77.9068 |
|        7 | Investigating the miRNAs as potential biomarkers to classify autism phenotype for clinical management                                                                                                                           |                            53.0808 |
|        8 | Functional validation of lncRNAs involved in the molecular processes that underlie the development of Congenital Heart Disease                                                                                                  |                            39.9461 |
|        9 | Cell and Developmental Biology of Marine Organisms under Marine Bioresource and Biotechnology Network Programme                                                                                                                 |                           499.83   |
|       10 | Identification of genes that promote proliferation of germline stem cells in Caenorhabditis elegans                                                                                                                             |                            45.6776 |
|       11 | Impact of COVID-19 on clinical manifestations, diagnosis, treatment outcome and immune response for pulmonary tuberculosis                                                                                                      |                            48.486  |
|       12 | Bioprospecting of Marine microbial diversity for various products under the Marine Bioresource and Biotechnology Network Programme                                                                                              |                           204.268  |
|       13 | MIMSA: Role of the oral microbiome &mucosal immunity in COVID-19 disease: diagnostic/prognostic utility in South Asian populations                                                                                              |                            44.3016 |
|       14 | 'CoV-Ind-UK' 'Prospective investigation of the determinants for COVID- 19 outcomes amongst South Asians in India and the United Kingdom'                                                                                        |                            21.8568 |
|       15 | Precision brackishwater aquaculture technology using Machine Intelligence                                                                                                                                                       |                           132.459  |
|       16 | Dissemination of Arbuscular Mycorrhizal fungi (AM fungi) production technology (carrier and liquid formulation) to enhance and empower the livelihood of farm women in the Aspirational district (Ramanathapuram) of Tamil Nadu |                            28.3352 |

|   17 | Banana Shakti Nanoformulations - Effective delivery systems of the micronutrient mixture for improved banana cultivation    |   36.2445 |
|------|-----------------------------------------------------------------------------------------------------------------------------|-----------|
|   18 | Development of Zinc-Selenide-Cerium Nanocomposite and Quantifying Its Potential on Alleviation of Drought Stress on Sorghum |   37.6956 |
|   19 | Development of Automated Low-Cost Reader for Soil NPK Detection using Printed Electrode with Integrated Android Application |   35.8436 |

## 2. R&D Projects sanctioned by BIRAC in Tamil Nadu

|   S. No. | Name of project                                                                                                                      |   Sanctioned amount (in Rs. lakhs) |
|----------|--------------------------------------------------------------------------------------------------------------------------------------|------------------------------------|
|        1 | Eco-friendly management of Citrus Greening Disease through phloem specific Delivery of IMPDH inhibitors encapsulated in Nano system. |                               36.4 |

## ANNEXURE B

## 1. R&D Projects sanctioned by DBT in other States

|   S. No. | Name of project                                                                                                                                                                                                                                                                                                                                    |   Sanctioned amount (in Rs. lakhs) |
|----------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|------------------------------------|
|        1 | Characterization of interaction of SARS Cov-2 spike protein with placental endothelial cells for developing CoV-2 inhibitors                                                                                                                                                                                                                       |                             7.838  |
|        2 | Early mesoderm patterning: Mechanism underlying the emergence of organogenic progenitors                                                                                                                                                                                                                                                           |                            80.8615 |
|        3 | Developing double herbicide tolerant pigeonpea for improved weed management employing two pronged approach: haplotype mining in native germplasm and CRISPR/Cas9 mediated genome editing tool                                                                                                                                                      |                            70.5336 |
|        4 | Chitosan based nanoparticulate delivery system for the effective delivery of calcium and its impact on productivity of groundnut                                                                                                                                                                                                                   |                            53.058  |
|        5 | Centre for depression diagnosis and medication adherence                                                                                                                                                                                                                                                                                           |                            66.36   |
|        6 | Development of novel gallium-based metallodrugs as chemotherapeutic anticancer agents                                                                                                                                                                                                                                                              |                            32.7959 |
|        7 | Multi-institutional approach on development of technology driven bio- input production clusters for mass production of biofertilizers and biopesticides for promotion of eco-friendly farming with collateral development of bio- entrepreneurship in vegetables, spices and small tea growers of North East Region of India for better livelihood |                           133.5    |
|        8 | Catalyzing Complementary Olericulture in Assam, Arunachal Pradesh and Nagaland for Livelihood Security by Provisioning Quality Seed and Seedling of Indigenous and Commercial Vegetables Generated through Hi Tech Mini Plug Nursery and Conventional Means and Promotion of Bio- Enterprise                                                       |                           259.576  |
|        9 | Establishment of Bioresource Centre for making S&T Intervention in Banana Value Chain for Socio Economic Development in Udalguri District, Assam                                                                                                                                                                                                   |                            69.2099 |
|       10 | Bio-surfactant mediated enhanced oil recovery for Assam oil reservoirs                                                                                                                                                                                                                                                                             |                            36.4    |
|       11 | Biopolymer based Electrospun Membranes for Recovery of Heavy Metals from industrial Wastewater                                                                                                                                                                                                                                                     |                             8.0352 |
|       12 | Root exudates modified hydrogel - nano LDH - bacteria loaded composite system for efficient generation of plant available phosphorus.                                                                                                                                                                                                              |                            32.7812 |
|       13 | Nanotechnological interventions in dental and bone metal implants: Tailoring smart, multifunctional interfaces towards improved osseointegrative and anti-bacterial properties                                                                                                                                                                     |                            38.2524 |
|       14 | Development of herbicides against Acetyl Co-A Carboxylase to address resistance and cross resistance in Phalaris minor: A weed of wheat crop field                                                                                                                                                                                                 |                            50.372  |
|       15 | Imaging intracellular replication and various stages of Theileria parasite infection by overcoming resolution limitations                                                                                                                                                                                                                          |                             7.041  |

|   16 | Validation and characterization of novel functional role of SARS-CoV-2 ORF8 protein in tricking host complement system using molecular mimicry                                              |   23.6186 |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-----------|
|   17 | Understanding the Role of Ser/Thr Protein Kinases in the regulation of Toxin-Antitoxin loci in Mycobacterium tuberculosis                                                                   |  123.863  |
|   18 | Prions as stress sensors in plants: Role of DNA/RNA binding proteins in regulating stress memory                                                                                            |   25.624  |
|   19 | Deciphering the cross-talk between Toll Like Receptors and C-type-Lectin Receptors in mediating immune responses upon mycobacterial infection                                               |   38.4    |
|   20 | Understanding Inter Compartmental Crosstalk between Insulin-sensitive and insulin-resistant obese and non-obese phenotypes using Adipose Tissue                                             |   61.8136 |
|   21 | Electrochemical ultra-sensing platform integrated with biomarker coated on graphene detecting neonatal sepsis                                                                               |   26.4365 |
|   22 | Investigation of Key splicing events Modulated in DENV Infection                                                                                                                            |   52.3    |
|   23 | Efficacy of a PD-1 as an Adjunct Immunotherapy in Tuberculosis Patients                                                                                                                     |  126.28   |
|   24 | Biotechnological approaches to improve shelf life, productivity of vegetables-(Tomato).                                                                                                     |   43.224  |
|   25 | Understanding the Epigenetic Regulation of T cell Responses during Tuberculosis                                                                                                             |   24.4336 |
|   26 | Designing precision therapies by targeting cancer-specific synthetic lethal genetic interactions                                                                                            |   24.4336 |
|   27 | Development of technologies for measuring and maintaining ecosystem services from forests                                                                                                   |   16.575  |
|   28 | Development ofBCMA based Chimeric antigenic receptor T (CAR T) cell in Multiple myeloma (MM).                                                                                               |   98.9423 |
|   29 | Deciphering the role of microRNA-191, in regulation of chemoresistance and stemness in breast cancer                                                                                        |   39.3352 |
|   30 | Deciphering the role of SIX genes in virulence and host-specificity of Fusarium oxysporum f. sp. carthami                                                                                   |   73.4952 |
|   31 | Targeting Pup1 independent mechanisms for improving low soil phosphorus tolerance and use-efficiency in rice                                                                                |  124.69   |
|   32 | Network Programme for Enrichment and Update of Database on Genome Related Information for Indian Spermatophyta and Archegoniatae Taxa- Phase II                                             |   35.4672 |
|   33 | 'CARDINNATE''Variation in innate immune activation and cardiovascular disease risk as drivers of immune pathology in COVID19 outcome in South Asians in UK and India'                       |   51.9912 |
|   34 | DiSeCT':'Explaining the differential severity of COVID-19 between Indians in India and the UK                                                                                               |   95.016  |
|   35 | 'CoV-Ind-UK' 'Prospective investigation of the determinants for COVID- 19 outcomes amongst South Asians in India and the United Kingdom'                                                    |   31.0824 |
|   36 | Electrochemical sensor connected to smart phone app for club drug detection at point of need                                                                                                |   31.5792 |
|   37 | EVALUATION OF EFFECT OF MACROPHYTES-BASED FEED ON THE GROWTH, GUT PHYSIOLOGY, EXPRESSION OF SPECIFIC GENES INVOVED IN THE BIOSYNTHESISOFDHA& EPA AND PRODUCTION OF QUALITY FRESWATER FISHES |   93.1704 |

|   38 | Combined neurological and functional assessments for the prediction and appreciation of individualized recovery profiles an international study benchmarking clinical outcomes in acute spinal cord injury   |   138.6568 |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|------------|
|   39 | Developing double herbicide tolerant pigeonpea for improved weed management employing two pronged approach: haplotype mining in native germplasm and CRISPR/Cas9 mediated genome editing tool                |   121.672  |
|   40 | Development of a sophisticated illumination device for regulating algal photoreceptors for enhancing photosynthetic and metabolic efficiency                                                                 |    96.1177 |
|   41 | Mapping and transfer of novel resistance genes for multiple biotic stresses in wheat (Triticum aestivum L.)                                                                                                  |   165.243  |
|   42 | Nanotechnological interventions in dental and bone metal implants: Tailoring smart, multifunctional interfaces towards improved osseointegrative and anti-bacterial properties                               |    30.4244 |
|   43 | Bioprospecting of Marine microbial diversity for various products under the Marine Bioresource and Biotechnology Network Programme                                                                           |   105.11   |
|   44 | Deployment and piloting of Improved Indigenous Fermented Food Product, 'Chubitchi' and 'Tungrymbai' for the sustainable Livelihood in Meghalaya, Northeast India                                             |    20.4352 |
|   45 | Ultrasound-enabled oncotripsy for breast cancer treatment                                                                                                                                                    |    22.5712 |
|   46 | Bioprospecting of Marine microbial diversity for various products under the Marine Bioresource and Biotechnology Network Programme                                                                           |    62.5048 |
|   47 | Inter-Institutional Program for Maternal, Neonatal and Infant Sciences A translational approach -interdisciplinary Group for Advanced Research on BirtH outcomes - DBT INdia Initiative (GARBH-Ini Phase II) |  2626.15   |
|   48 | Modulating effective connectivity in the 'agency network' of humans                                                                                                                                          |    24.4336 |
|   49 | A mass spectrometric approach to unravel the landscape of sphingolipids as major signaling determinants of drug resistance and virulence in emerging human fungal pathogen Candida auris                     |    64.4577 |
|   50 | Generation of milk somatic cell reference values and intelligent predictive modelling for monitoring mammary profile and milk quality of indigenous dairy animals                                            |    73.0607 |
|   51 | DBT Network Programme on Anthrax Diagnosis and Control in India                                                                                                                                              |  1006.15   |
|   52 | YAP function in growth factor receptor signalling in mammary epithelial cells during growth control and tumorigenesis.                                                                                       |    61.868  |
|   53 | Nanocarriers for topical delivery of pathogen-specific RNAi molecules for sustained protection of pea crop against powdery mildew                                                                            |    38.3352 |
|   54 | Development of an aptamer-based diagnostic kit for detection of Campylobacter infections in cattle and poultry.                                                                                              |    55.9424 |
|   55 | Network Programme for Enrichment and Update of Database on Genome Related Information for Indian Spermatophyta and Archegoniatae Taxa- Phase II                                                              |    66.6096 |
|   56 | Deciphering the molecular mechanisms of dysregulation caused by mutations in LSD1 leading to Intellectual Disability                                                                                         |    24.4336 |
|   57 | Investigating the molecular basis of inositol pyro phosphate regulation in Arabidopsis thaliana                                                                                                              |    24.4336 |

|   58 | Potential role of mitochondrial uncoupling protein 2 as a biomarker in patients with sepsis and septic shock: An observational study                                  |   14.768 |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|
|   59 | Fuel supply to the Human placenta: Maternal obesity and placental trafficking of amino acids and fatty acids                                                          |  79.277  |
|   60 | Molecularly Imprinted Polymers (MIPs) based Electrochemical Biosensors for Selective Bio-analyte Detection                                                            |  26.2256 |
|   61 | Delineation of SLIT-ROBO signaling derived molecular intermediates in the regulation of oxidative stress responses upon virulent mycobacterial infection              | 103.031  |
|   62 | Role and regulation of stress-induced autophagy in proteostasis mechanisms underlying artemisinin resistance                                                          |  29.928  |
|   63 | Lessons from bacterial warfare: Using microbial evolutionary arms-race for the identification of novel antibiotic resistance mechanism and antimicrobial strategies   |  24.4336 |
|   64 | Deep Phenotyping, Comprehensive Genomic Studies and Investigations into Pathomechanisms of Congenital Heart Defects                                                   |  64.9722 |
|   65 | Valorization of byproducts from fish industry: Isolation and characterization of glycosaminoglycans for various applications                                          |  44.2576 |
|   66 | Profile of Micronutrient Deficiency nutritional status and cognitive dysfunction among elderly residing in tribal areas of Southern Karnataka                         |  26.0804 |
|   67 | Role of Human antigen R (HuR) in Coxsackievirus life cycle and virus induced Myocarditis                                                                              |  79.5384 |
|   68 | Exploring the combination of new Topoisomerase I inhibitors with frontline anti-TB drugs on intracellular Mycobacterium tuberculosis survival                         | 165.548  |
|   69 | Shortening Tuberculosis Therapy Duration using Chloroquine/Hydroxycholoroquine                                                                                        |  88.7869 |
|   70 | "Studies on population diversity and role of host plant volatiles cues for enhancing egg laying in temperate tasar silk moths (Antheraea proylei)                     |  26.9336 |
|   71 | 'CARDINNATE''Variation in innate immune activation and cardiovascular disease risk as drivers of immune pathology in COVID19 outcome in South Asians in UK and India' |  60.876  |
|   72 | DiSeCT':'Explaining the differential severity of COVID-19 between Indians in India and the UK                                                                         |  10.412  |
|   73 | PRESCRIP-TEC': 'Prevention and Screening Innovation Project towards Elimination of Cervical Cancer                                                                    |  72.528  |
|   74 | Therapeutic potential of AHL analogues through neutrophil extracellular traps mediated bacterial clearance during chronic obstructive pulmonary disease               |  42.57   |
|   75 | Translational platforms for discovery, repurposing, and clinical development for COVID-19 therapeutics                                                                | 442.681  |
|   76 | SARS-CoV-2 Network for Genomic Surveillance in Brazil, Russia, India, China and South Africa NGS-BRICS                                                                |  10.416  |
|   77 | Unravelling signatures of growth and salinity adaptation in Etroplussuratensis through omics approaches                                                               |  11.1    |

|   78 | Unrevealing the entry mechanism of Tick-borne Kyasanur Forest diseases Virus                                                                                                                                                                                                                 |    31.93 |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|
|   79 | Profiling the epigenetic signatures induced in plants by the dung of indigenous cow varieties                                                                                                                                                                                                |  39.676  |
|   80 | Development of plasticizer free acrylic denature soft liners using nanogel additives                                                                                                                                                                                                         |  23.5024 |
|   81 | Functional Analysis of putative S genes in pomegranate bacterial blight interaction                                                                                                                                                                                                          |  63.226  |
|   82 | Cell and Developmental Biology of Marine Organisms under Marine Bioresource and Biotechnology Network Programme                                                                                                                                                                              | 301.226  |
|   83 | Bioprospecting of Marine microbial diversity for various products under the Marine Bioresource and Biotechnology Network Programme                                                                                                                                                           |  83.0416 |
|   84 | Development of Novel Benzo fused Heterocycles to Improve the Treatment of Drug Resistant Tuberculosis                                                                                                                                                                                        |  18.3952 |
|   85 | A longitudinal study of COVID-19 infected patients for convalescent plasma therapy                                                                                                                                                                                                           |  42.0072 |
|   86 | OVOL-alpha-actinin-4 crosstalk in EMT and breast cancer stemness                                                                                                                                                                                                                             | 110.593  |
|   87 | Elucidating the effects of organ ismal aging on the signalling micro- environment in the niche-stem cell ecosystem and its impact on immunity in Drosophila                                                                                                                                  |  24.4336 |
|   88 | Role and regulation of stress-induced autophagy in proteostasis mechanisms underlying artemisinin resistance                                                                                                                                                                                 |  39.8039 |
|   89 | Evaluating the role and proteolytic processing of Trop1 and Trop2 in normal placentation and placental pathologies                                                                                                                                                                           |  33.5384 |
|   90 | Dissection of signalling mechanisms that couple flagella biogenesis to cytokinesis in bacteria                                                                                                                                                                                               |  79.7007 |
|   91 | Design and development of a microfluidic chip for sperm selection/sorting based on chemotaxis                                                                                                                                                                                                |  28.0872 |
|   92 | Bioprospecting of Marine microbial diversity for various products under the Marine Bioresource and Biotechnology Network Programme                                                                                                                                                           | 140.71   |
|   93 | Dry Powder Inhalation Containing Biodegradable Nanoparticles Of Niclosamide To Combat Covid-19 Infection                                                                                                                                                                                     |  44.0848 |
|   94 | Regulation of 14-3-3 ligand interactions by conserved residues in the phospho-peptide binding pocket.                                                                                                                                                                                        | 166.678  |
|   95 | Catalyzing Complementary Olericulture in Assam, Arunachal Pradesh and Nagaland for Livelihood Security by Provisioning Quality Seed and Seedling of Indigenous and Commercial Vegetables Generated through Hi Tech Mini Plug Nursery and Conventional Means and Promotion of Bio- Enterprise |  67.1473 |
|   96 | Distribution of pathogenic micoraerophilic Arcobacter sp. in seafood and development of a rapid method for its detection                                                                                                                                                                     |  52.9236 |
|   97 | Functional significance of testis specific histone H2B variant(TH2B) in spermatozoa and early embryonic development                                                                                                                                                                          |  54.3332 |
|   98 | Network Programme for Enrichment and Update of Database on Genome Related Information for Indian Spermatophyta and Archegoniatae Taxa- Phase II                                                                                                                                              |  33.0048 |
|   99 | YAP function in growth factor receptor signalling in mammary epithelial cells during growth control and tumorigenesis.                                                                                                                                                                       |  24.668  |

|   100 | PRESCRIP-TEC': 'Prevention and Screening Innovation Project towards Elimination of Cervical Cancer                                                                                                                                                                                                                                                 |   39.0192 |
|-------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-----------|
|   101 | Nano-mediated rapid detection and biocontrol of downy and powdery mildew of grapes and powdery mildew of tomatoes                                                                                                                                                                                                                                  |   57.38   |
|   102 | Investigating the osteogenic potential of extracellular vesicles loaded injectable hydrogels                                                                                                                                                                                                                                                       |   36.4384 |
|   103 | Developing a system-level model of the human cochlea using measured otoacoustic emissions and psychophysical tuning curves                                                                                                                                                                                                                         |   22.7336 |
|   104 | DBT-ICT CENTRE FOR EXCELLENCE For Bioprocessing for Bioenergy and Biochemicals (DBT-ICT CoE3B)                                                                                                                                                                                                                                                     |  698.638  |
|   105 | "Studies on population diversity and role of host plant volatiles cues for enhancing egg laying in temperate tasar silk moths (Antheraea proylei)                                                                                                                                                                                                  |   73.0136 |
|   106 | Deployment and piloting of Improved Indigenous Fermented Food Product, 'Chubitchi' and 'Tungrymbai' for the sustainable Livelihood in Meghalaya, Northeast India                                                                                                                                                                                   |   76.6343 |
|   107 | Multi-institutional approach on development of technology driven bio- input production clusters for mass production of biofertilizers and biopesticides for promotion of eco-friendly farming with collateral development of bio- entrepreneurship in vegetables, spices and small tea growers of North East Region of India for better livelihood |   38.3348 |
|   108 | Network Programme for Enrichment and Update of Database on Genome Related Information for Indian Spermatophyta and Archegoniatae Taxa- Phase II                                                                                                                                                                                                    |   52.932  |
|   109 | Catalyzing Complementary Olericulture in Assam, Arunachal Pradesh and Nagaland for Livelihood Security by Provisioning Quality Seed and Seedling of Indigenous and Commercial Vegetables Generated through Hi Tech Mini Plug Nursery and Conventional Means and Promotion of Bio- Enterprise                                                       |   98.9896 |
|   110 | Deployment and piloting of Improved Indigenous Fermented Food Product, 'Chubitchi' and 'Tungrymbai' for the sustainable Livelihood in Meghalaya, Northeast India                                                                                                                                                                                   |   26.2    |
|   111 | Deciphering the role of DZIP3, a RNA binding E3-Ligase in innate immunity and viral restriction                                                                                                                                                                                                                                                    |   97.6803 |
|   112 | "Impact of climate change on the emergence of stress tolerant Symbiodinium clade and altered microbiome in reef building corals' under the Marine Bioresource and Biotechnology Network Programme                                                                                                                                                  |  351.683  |
|   113 | Hierarchically organized amino acid/protein core-shell nanobowls with 2 photon responsive off-on switchable lids for light activable delivery of an array of anti miRNA therapeutics in glioblastoma                                                                                                                                               |   23.5024 |
|   114 | Rice stubble management through altered genotype x environment x management (GEM) interventions in wheat crop                                                                                                                                                                                                                                      |   28.6548 |
|   115 | Antisense oligonucleotide-loaded, 3D printed, double-layered, and multifunctional wound healing matrix to target angiogenesis in chronic diabetic wounds                                                                                                                                                                                           |   37.5712 |
|   116 | Development of Aptamer-based multiple biosensors for sensing of pesticides in real time                                                                                                                                                                                                                                                            |   23.5712 |
|   117 | Enhanced osteogenesis promoted by bone injury specific co-delivery of BMP2 and Noggin Si-RNA loaded in microfluidically fabricated amino acid-based nanobowls with pH tunable lids                                                                                                                                                                 |   44.4712 |

|   118 | Development of resistant starch potato using nanomaterial-mediated genome editing technology                                                                            |   45.3912 |
|-------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-----------|
|   119 | Nanocarriers for topical delivery of pathogen-specific RNAi molecules for sustained protection of pea crop against powdery mildew                                       |   25.176  |
|   120 | DBT PAN IIT Center For Bioenergy : Phase II                                                                                                                             |  148.414  |
|   121 | PRESCRIP-TEC': 'Prevention and Screening Innovation Project towards Elimination of Cervical Cancer                                                                      |   20.5136 |
|   122 | Design and Development of cost-effective Label-free detection of Alzheimer's biomarkers using liquid crystals                                                           |   37.4    |
|   123 | Inorganic polyphosphate in eukaryotes - synthesis, detection, metabolism and physiology                                                                                 |   51.6244 |
|   124 | Studying the efficacy of PPE2 protein in the treatment of inflammation and tissue injury                                                                                |   57.648  |
|   125 | Understanding the growth and regulation of bacterial cell envelope                                                                                                      |   63.5565 |
|   126 | Establishment of a Consortium for One Health to address Zoonotic and Transboundary Diseases in India, including the Northeast Region                                    | 3110.09   |
|   127 | Development of Novel Benzo fused Heterocycles to Improve the Treatment of Drug Resistant Tuberculosis                                                                   |    1.5    |
|   128 | Characterization of interaction of SARS Cov-2 spike protein with placental endothelial cells for developing CoV-2 inhibitors                                            |   30.788  |
|   129 | Elucidating the role of chromatin re modelers in yeast meiosis, especially in meiotic recombination, chromosome segregation and transcription of meiosis-specific genes |   25.624  |
|   130 | Development of affordable Immunochromatographic Test (ICT) based onrecombinant proteins for point-of-care detection of Toxoplasma gondii infection                      |   23.642  |
|   131 | Characterization of human E2 enzyme Ube2N response to DNA                                                                                                               |   35.1365 |
|   132 | Studies on the regulation of cell size, membrane biogenesis and fabY a novel gene contributing to fatty acid metabolism by (p)ppGpp&DksA                                |   61.5728 |
|   133 | Mechanistic studies on the divergent regulation of potassium transporters belonging to distinct protein families by dephospho-PtsN in Escherichia coli                  |   44.4336 |
|   134 | Post-transcriptional regulation in Acinetobacter baumannii DS002: Role of novel small RNA, AbcR200 in regulation of lut (lactate utilization) operon                    |   48.1308 |
|   135 | Elucidating the role of histone H3 lysine methylation in antifungal drug resistance                                                                                     |   94.9892 |
|   136 | Regulation of Innate dsRNA Sensing Pathways by Epithelial mesenchymal transition-TFs                                                                                    |   75.3386 |
|   137 | Phenotypic characterization of ruminant B cells from precursors to effector cells: Phase I                                                                              |   57.2416 |
|   138 | Studies on the immunodominant proteins of the zoonotic pathogen, Brucella to develop improved diagnostic assays and vaccines for brucellosis.                           |   84.4384 |
|   139 | Identification of key molecular players specially lncRNAs involved in response to NDV challenge in indigenous and exotic chicken breeds using RNA-seq analysis.         |   18.196  |

|   140 | Therapeutic protein production in milk of farm animals to increase their affordability.                                                                                                           |   230.36076 |
|-------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-------------|
|   141 | Development of novel gallium-based metallodrugs as chemotherapeutic anticancer agents                                                                                                             |     17.2    |
|   142 | Targeting Pup1 independent mechanisms for improving low soil phosphorus tolerance and use-efficiency in rice                                                                                      |    130.355  |
|   143 | Validation of DBT-NIAB SNP chip for Breed Identification and Preliminary Genome Wide Association Studies on Milk yield                                                                            |     57.7268 |
|   144 | SARS-CoV-2 Network for Genomic Surveillance in Brazil, Russia, India, China and South Africa NGS-BRICS                                                                                            |     12.4992 |
|   145 | Investigating the role and regulation of transcription factor Grainyhead in Drosophila neural stem cells.                                                                                         |    106.667  |
|   146 | Establish A Drug Metabolomics Lab For North Eastern States                                                                                                                                        |    418.269  |
|   147 | Design and fabrication of amperometric enzyme sensors for the detection of parabens                                                                                                               |     34.7736 |
|   148 | Identification of genetic determinants and risk factors for drug resistance to bedaquiline and delamanid in native isolates of Mycobacterium tuberculosis in India                                |     30.142  |
|   149 | Bridging the genomic and transcriptional heterogeneity in oral cancer for identifying clinically relevant features                                                                                |     24.616  |
|   150 | Electrochemical ultra-sensing platform integrated with biomarker coated on graphene detecting neonatal sepsis                                                                                     |      6.5176 |
|   151 | A mass spectrometric approach to unravel the landscape of sphingolipids as major signaling determinants of drug resistance and virulence in emerging human fungal pathogen Candida auris          |     18.9024 |
|   152 | A study on the intergenerational effect of Maternal Vitamin D3 deficiency on cognition and hippocampal neurons in rats                                                                            |     68.3502 |
|   153 | Identification of key molecular players specially lncRNAs involved in response to NDV challenge in indigenous and exotic chicken breeds using RNA-seq analysis.                                   |     31.4184 |
|   154 | Exploring DNA Transactions and Genome Maintenance in the Malaria Parasite                                                                                                                         |    193.892  |
|   155 | Establish SCHOOL OF INTERNATIONAL BIODESIGN (SIB)- Synergizing healthcare, innovation and entrepreneurship (SHInE)                                                                                |    921.838  |
|   156 | Bioprospecting of Marine microbial diversity for various products under the Marine Bioresource and Biotechnology Network Programme                                                                |     43.116  |
|   157 | Elucidating the Mechanism of Small RNAs and RNA Chaperone Hfq in Antibiotic Tolerance and Virulence in Acinetobacter baumannii                                                                    |     87.7152 |
|   158 | Treatment of Septage using lab and pilot-scale Hybrid Constructed Wetland system in Dehradun, Uttarakhand                                                                                         |     42.5104 |
|   159 | The genetic control of morphological and ionomic adaptation during the colonization of India by grain amaranth                                                                                    |     94.8818 |
|   160 | "Impact of climate change on the emergence of stress tolerant Symbiodinium clade and altered microbiome in reef building corals' under the Marine Bioresource and Biotechnology Network Programme |     26.7736 |
|   161 | Computer-aided Glioblastoma and Intracranial Aneurysms Treatment Response Quantification in Neuroradiology                                                                                        |     39.6948 |

|   162 | Developing a nature-inspired, general approach for enzymatic synthesis of hybrid biopolymer peptide oligonucleotide conjugates                                                                         |    10.0 |
|-------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|---------|
|   163 | DBT PAN IIT Center For Bioenergy : Phase II                                                                                                                                                            | 92.58   |
|   164 | Structural and functional characterization of Mycobacterium tuberculosis ß-hydroxyacyl-ACP dehydratase &monooxygenases for understanding its thiourea mediated mode of inhibition                      | 61.55   |
|   165 | Campylobacter Jejuni Outer Membrane Vesicles: Role in Host Pathogen Interaction and vaccine perspectives                                                                                               | 39.578  |
|   166 | Assessing the immuno-therapeutic potential of type III interferons-IFNs ( IFN-?) against Avian Influenza virus (AIV) infections in murine and chickens models                                          | 43.552  |
|   167 | AI based Detection of Acute Respiratory Distress Syndrome (AI-DARDS): An artificial intelligence aided non-contact framework for detecting acute respiratory distress syndrome using microwave sensors | 49.3387 |
|   168 | PRESCRIP-TEC': 'Prevention and Screening Innovation Project towards Elimination of Cervical Cancer                                                                                                     | 61.3318 |
|   169 | SARS-CoV-2 Network for Genomic Surveillance in Brazil, Russia, India, China and South Africa NGS-BRICS                                                                                                 | 67.8252 |

## 2. R&D Projects sanctioned by BIRAC in other States

|   S. No. | Name of project                                                                                                                                                                                                                     |   Sanctioned amount (in Rs. lakhs) |
|----------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|------------------------------------|
|        1 | Generation and Characterization of third party donor derived AdV,CMV and EBV multivirus specific T cells for therapeutic intervention in patients undergoing Hematopoietic Stem Cell Transplantation                                |                             50     |
|        2 | Development Of Smart Vision Inspection System For Identification And Removal Of Foreign Particles During Black Tea Processing                                                                                                       |                             50     |
|        3 | Overcoming the problem of high oxygen demand by using formate instead of methanol to induce the AOX1 promoter of Komagataella phaffii Pichia pastoris                                                                               |                             35.78  |
|        4 | Development of a glutamate-inducible Pichia pastoris yeast expression system                                                                                                                                                        |                             47.784 |
|        5 | Pre-clinical evaluation of promising drugs for a rare syndromic cardiomyopathy in children                                                                                                                                          |                             49.98  |
|        6 | TITLE: Double-blind randomized control trial for a novel algorithm P-Score on variables including OCTbased phenotyping and soluble plasma VEGFR2 for the stratification of Anti VEGF Therapy response among Diabetic Macular Edema. |                             40     |
|        7 | Development of Lateral Flow Assay Kit for diagnosis of pebrine disease in silkworms                                                                                                                                                 |                             46.12  |