Lok Sabha Question No. 3493 (UNSTARRED), answered on 2021-08-10
Subject: Guidelines for FDCs
Ministry: CHEMICALS AND FERTILIZERS
Asked by: Bhola Singh, Sangamlal Kadedin Gupta, Raja Amareshwara Naik, Ranjeetsingh Naik Nimbalkar, Sukanta Majumdar, Jayanta Kumar Roy, P.P. Chaudhary, Vinod Kumar Sonkar, Rajveer (Raju Bhaiya) Singh, Sangeeta Kumari Singh Deo, Sunil Kumar Singh, Sangamlal Kadedin Gupta, Raja Amareshwara Naik

## GOVERNMENT OF INDIA MINISTRY OF CHEMICALS AND FERTILIZERS DEPARTMENT OF PHARMACEUTICALS

LOK SABHA UNSTARRED QUESTION No. 3493 TO BE ANSWERED ON THE 10 th  AUGUST, 2021

## Guidelines for FDCs

## 3493.   SHRI BHOLA SINGH:

SHRI JAGDAMBIKA PAL:

SHRI ARJUN LAL MEENA:

SHRI RANJEETSINGH HINDURAO NAIK NIMBALKAR:

DR. SUKANTA MAJUMDAR

DR. JAYANTA KUMAR ROY:

SHRI P.P. CHAUDHARY:

SHRI VINOD KUMAR SONKAR:

SHRI RAJVEER SINGH (RAJU BHAIYA):

SHRIMATI SANGEETA KUMARI SINGH DEO:

SHRI SUNIL KUMAR SINGH:

SHRI SANGAM LAL GUPTA:

SHRI RAJA AMARESHWARA NAIK:

Will the Minister of CHEMICALS AND FERTILIZERS be pleased to state:

- (a) whether the Government has framed guidelines for the approval and use of Fixed Drugs Combinations (FDC) in the country and if so, the details thereof;
- (b) whether the Government plans to increase monitoring of the usage of FDC drugs in the country and if so, the details thereof;
- (c) whether the Government asked National Pharmaceuticals Pricing Authority (NPPA) and Indian  Council  of  Medical  Research  (ICMR)  to  study  the  usage  and  prescription  of  FDC medicines in the country and if so, the details thereof;
- (d) whether the Government has banned some FDC medicines on the recommendations of Prof
- C K Kokate Committee; and
- (e) if so, the list of such FDC medicines?

## ANSWER

## MINISTER IN THE MINISTRY OF CHEMICALS & FERTILIZERS (SHRI MANSUKH MANDAVIYA)

- (a): The Central Drugs Standard Control Organisation (CDSCO) under MoHFW has informed that the New Drugs and Clinical Trial Rules, (NDCT) 2019 have been published, vide Gazette notification  no.  G.S.R.227(E) dated 19.03.2019. The Second Schedule of the NDCT Rules 2019, provides detailed requirements for approval of Fixed Dose Combinations in the country.
- (b) to (d): The manufacture, sale and distribution of drugs in the country are regulated under the provisions of the Drugs & Cosmetics Act, 1940 and Rules thereunder through a system of licensing and inspection. Licenses for manufacture, sale and distribution of drugs are granted

by the State Licensing Authorities (SLAs) appointed by respective State Governments. Under the said Rules, for manufacture of any New Drug, permission is required from Central Drugs Standard Control Organisation (CDSCO) before obtaining manufacturing license for the New Drug from the concerned State Licensing Authority. Under the afore-said Act, manufacture/sale/distribution  of  any  banned  drug  is  a  punishable  offence.  State  Licensing Authorities are empowered to take action in this regard. Some cases of grant of manufacturing license of new drugs including Fixed Dose Combinations (FDCs) falling under the purview of Rule 122E of the Drugs & Cosmetics Rules, 1945 by some of the State Licensing Authorities (SLAs) without due approval of the Drugs Controller General (India) [DCG (I)] came to the notice of the Government.

Apart from issuing repeated statutory directions under Section 33P of the Drugs & Cosmetics  Act,  1940  to  the  State  Governments  in  this  regard,  the  Central  Government constituted an Expert Committee under the chairmanship of Prof C.K. Kokate to examine the safety and efficacy of such FDCs. Based on the recommendations of the Prof. C. K. Kokate Expert  Committee,  the  Central  Government  prohibited  344  FDCs  vide  notification  dated 10.03.2016. Further, the Central Government also prohibited 5 FDCs vide notification dated 08.06.2017. However, with respect to the said 344 FDCs, several writ petitions were filed in different High Courts across the country challenging the ban of the FDCs. After that, the High Court of Delhi vide its order dated 01.12.2016 quashed the said notification. The Union of India challenged the said order of Delhi High Court before the Supreme Court by way of filing Special Leave Petition (SLP). Further, 20 cases against 5 FDCs prohibited on 08.06.2017 which were pending before various High Courts across the country, were also transferred to Hon'ble Supreme Court. Hon'ble Supreme Court vide its order dated 15.12.2017 directed that an analysis be made in greater depth and these cases of (344+5) FDCs should go to the Drugs Technical Advisory Board (DTAB) and/or a Sub-Committee formed by the DTAB for the purpose of having a relook into these cases.

Accordingly,  a  Sub-Committee  of  DTAB  was  constituted  which,  after  providing hearing to all the petitioners/appellants, submitted its report to DTAB which was accepted by DTAB. Based on the recommendations of DTAB, the Central Government vide notifications dated 07.09.2018 prohibited 328 FDCs for manufacture, sale or distribution as there was no therapeutic justification for these FDCs and they could involve risk to human beings. The Government  also  restricted  06  FDCs  for  manufacture,  sale  or  distribution  with  certain conditions vide notifications issued on the same date. However, various firms/stakeholders have filed writ petitions  in  various  High  Courts  across  the  country  including  the  Hon'ble Supreme Court against the said notifications dated 07.09.2018.

(e): The list of such banned FDCs is given in the Annexure .

## Annexure

|   S. No | Name of FDC                                                                  |   S. No | Name of FDC                                                                                                             |
|---------|------------------------------------------------------------------------------|---------|-------------------------------------------------------------------------------------------------------------------------|
|       1 | Aceclofenac + Paracetamol + Rabeprazole                                      |      26 | Glucosamine + Methylsulfonylmethane + Vitamin D3 + Manganese + Boron + Copper + Zinc                                    |
|       2 | Nimesulide + Diclofenac                                                      |      27 | Paracetamol +Tapentadol                                                                                                 |
|       3 | Nimesulide + Cetirizine + Caffeine                                           |      28 | Tranexamic Acid + Proanthocyanidin                                                                                      |
|       4 | Nimesulide + Tizanidine                                                      |      29 | Lornoxicam + Paracetamol + Tramadol                                                                                     |
|       5 | Paracetamol + Cetirizine + Caffeine                                          |      30 | Lornoxicam + Paracetamol + Serratiopeptidase                                                                            |
|       6 | Diclofenac + Tramadol + Chlorzoxazone                                        |      31 | Diclofenac + Paracetamol + Magnesium Trisilicate                                                                        |
|       7 | Dicyclomine + Paracetamol + Domperidone                                      |      32 | Paracetamol + Domperidone + Caffeine                                                                                    |
|       8 | Diclofenac + Tramadol + Paracetamol                                          |      33 | Ammonium Chloride + Sodium Citrate + Chlorpheniramine Maleate + Menthol                                                 |
|       9 | Diclofenac + Paracetamol + Chlorzoxazone + Famotidine                        |      34 | Combikit of 3 Tablets of Serratiopeptidase (Enteric Coated 20000 units) + Diclofenac Potassium &2Tablets of Doxycycline |
|      10 | Naproxen + Paracetamol                                                       |      35 | Nimesulide + Paracetamol Suspension                                                                                     |
|      11 | Nimesulide + Serratiopeptidase                                               |      36 | Aceclofenac + Paracetamol + Famotidine                                                                                  |
|      12 | Paracetamol + Diclofenac + Famotidine                                        |      37 | Aceclofenac + Zinc Carnosine                                                                                            |
|      13 | Nimesulide + Pitofenone + Fenpiverinium + Benzyl Alcohol                     |      38 | Paracetamol + Disodium Hydrogen Citrate + Caffeine                                                                      |
|      14 | Omeprazole + Paracetamol + Diclofenac                                        |      39 | Paracetamol + DL- Methionine                                                                                            |
|      15 | Nimesulide + Paracetamol Injection                                           |      40 | Disodium Hydrogen Citrate + Paracetamol                                                                                 |
|      16 | Tamsulosin + Diclofenac                                                      |      41 | Paracetamol + Caffeine + Codeine Phosphate                                                                              |
|      17 | Paracetamol + Phenylephrine + Chlorpheniramine + Dextromethorphan + Caffeine |      42 | Aceclofenac (SR) + Paracetamol                                                                                          |
|      18 | Diclofenac + Zinc Carnosine                                                  |      43 | Diclofenac + Paracetamol injection                                                                                      |
|      19 | Diclofenac + Paracetamol + Chlorpheniramine Maleate + Magnesium Trisilicate  |      44 | Azithromycin + Cefixime                                                                                                 |
|      20 | Paracetamol + Pseudoephedrine + Cetirizine                                   |      45 | Amoxicillin + Dicloxacillin                                                                                             |
|      21 | Phenylbutazone + Sodium Salicylate                                           |      46 | Azithromycin + Levofloxacin                                                                                             |
|      22 | Lornoxicam + Paracetamol + Trypsin                                           |      47 | Cefixime + Linezolid                                                                                                    |
|      23 | Paracetamol + Mefenamic Acid + Ranitidine + Dicyclomine                      |      48 | Amoxicillin +Cefixime + Potassium Clavulanic Acid                                                                       |
|      24 | Nimesulide + Dicyclomine                                                     |      49 | Ofloxacin + Nitazoxanide                                                                                                |
|      25 | Heparin + Diclofenac                                                         |      50 | Cefpodoxime Proxetil + Levofloxacin                                                                                     |
|      51 | Combikit of Azithromycin Dihydrate, Secnidazole and Fluconazole              |      76 | Clindamycin + Telmisartan                                                                                               |
|      52 | Levofloxacin + Ornidazole + alpha- Tocopherol Acetate                        |      77 | Olmesartan + Hydrochlorothiazide + Chlorthalidone                                                                       |

|   53 | Nimorazole + Ofloxacin                                                     |   78 | L-5-Methyltetrahydrofolate Calcium + Escitalopram                                         |
|------|----------------------------------------------------------------------------|------|-------------------------------------------------------------------------------------------|
|   54 | Azithromycin + Ofloxacin                                                   |   79 | Paracetamol +Promethazine                                                                 |
|   55 | Amoxicillin + Tinidazole                                                   |   80 | Betahistine + Ginkgo Biloba Extract + Vinpocetine + Piracetam                             |
|   56 | Doxycycline + Serratiopeptidase                                            |   81 | Cetirizine Dihydrochloride + Diethylcarbamazine                                           |
|   57 | Cefixime + Levofloxacin                                                    |   82 | Doxylamine + Pyridoxine + Mefenamic Acid + Paracetamol                                    |
|   58 | Ofloxacin + Metronidazole + Zinc Acetate                                   |   83 | Drotaverine + Clidinium + Chlordiazepoxide                                                |
|   59 | Diphenoxylate + Atropine + Furazolidone                                    |   84 | Flupentixol + Escitalopram                                                                |
|   60 | Combikit of Fluconazole Tablet, Azithromycin Tablet and Ornidazole Tablets |   85 | Gabapentin + Mecobalamin + Pyridoxine + Thiamine                                          |
|   61 | Ciprofloxacin + Phenazopyridine                                            |   86 | Imipramine +Chlordiazepoxide + Trifluoperazine +Trihexyphenidyl                           |
|   62 | Amoxicillin + Dicloxacillin + Serratiopeptidase                            |   87 | Chlorpromazine +Trihexyphenidyl                                                           |
|   63 | Azithromycin + Cefpodoxime                                                 |   88 | Ursodeoxycholic Acid + Silymarin                                                          |
|   64 | Lignocaine + Clotrimazole + Ofloxacin + Beclomethasone                     |   89 | Metformin 1000/1000/500/500 mg + Pioglitazone 7.5/7.5/7.5/7.5 mg + Glimepiride 1/2/1/2 mg |
|   65 | Cefuroxime + Linezolid                                                     |   90 | Gliclazide 80 mg + Metformin 325 mg                                                       |
|   66 | Ofloxacin + Ornidazole + Zinc Bisglycinate                                 |   91 | Voglibose + Metformin + Chromium Picolinate                                               |
|   67 | Metronidazole + Norfloxacin                                                |   92 | Pioglitazone 7.5/7.5 mg + Metformin 500/1000 mg                                           |
|   68 | Ciprofloxacin + Fluticasone + Clotrimazole +Neomycin                       |   93 | Glimepiride 1mg/2mg/3mg + Pioglitazone 15mg/15mg/15mg + Metformin 1000mg/1000mg/1000mg    |
|   69 | Metronidazole +Tetracycline                                                |   94 | Glimepiride 1mg/2mg+ Pioglitazone 15mg/15mg +Metformin 850mg/850mg                        |
|   70 | Cephalexin + Neomycin + Prednisolone                                       |   95 | Metformin 850 mg + Pioglitazone 7.5 mg + Glimepiride 2 mg                                 |
|   71 | Azithromycin + Ambroxol                                                    |   96 | Metformin 850 mg + Pioglitazone 7.5 mg + Glimepiride 1 mg                                 |
|   72 | Cilnidipine + Metoprolol Succinate + Metoprolol Tartrate                   |   97 | Metformin 500mg/500mg + Gliclazide SR 30mg/60mg + Pioglitazone 7.5mg/7.5mg                |
|   73 | L-Arginine + Sildenafil                                                    |   98 | Voglibose + Pioglitazone + Metformin                                                      |
|   74 | Atorvastatin + Vitamin D3 + Folic Acid + Vitamin B12 + Pyridoxine          |   99 | Metformin + Bromocriptine                                                                 |
|   75 | Metformin + Atorvastatin                                                   |  100 | Metformin + Glimepiride + Methylcobalamin                                                 |
|  101 | Pioglitazone 30 mg + Metformin 500 mg                                      |  126 | Ranitidine + Domperidone + Simethicone                                                    |
|  102 | Glipizide 2.5 mg + Metformin 400mg                                         |  127 | Alginic Acid + Sodium Bicarbonate + Dried Aluminium Hydroxide + Magnesium Hydroxide       |
|  103 | Pioglitazone 15 mg + Metformin 850 mg                                      |  128 | Clidinium + Paracetamol + Dicyclomine + Activated Dimethicone                             |

|   104 | Metformin ER + GliclazideMR+ Voglibose                                               |   129 | Furazolidone + Metronidazole + Loperamide                                                                                                        |
|-------|--------------------------------------------------------------------------------------|-------|--------------------------------------------------------------------------------------------------------------------------------------------------|
|   105 | Chromium Polynicotinate + Metformin Hydrochloride                                    |   130 | Rabeprazole + Diclofenac + Paracetamol                                                                                                           |
|   106 | Metformin Hydrochloride + Gliclazide + Pioglitazone + Chromium Polynicotinate        |   131 | Ranitidine + Magaldrate                                                                                                                          |
|   107 | Metformin + Gliclazide + Chromium Polynicotinate                                     |   132 | Norfloxacin+ Metronidazole + Zinc Acetate                                                                                                        |
|   108 | Metformin (sustained release) 500 mg + Pioglitazone 15 mg + Glimepiride 3mg          |   133 | Zinc Carnosine + Oxetacaine                                                                                                                      |
|   109 | Metformin (SR) 500mg + Pioglitazone 5mg                                              |   134 | Oxetacaine + Magaldrate + Famotidine                                                                                                             |
|   110 | Chloramphenicol + Beclomethasone + Clotrimazole + Lignocaine                         |   135 | Pantoprazole (as Enteric Coated Tablet) + Zinc Carnosine (as Film Coated Tablets)                                                                |
|   111 | Clotrimazole + Ofloxacin + Lignocaine + Glycerine and Propylene Glycol               |   136 | Zinc Carnosine + Magnesium Hydroxide + Dried Aluminium Hydroxide + Simethicone                                                                   |
|   112 | Chloramphenicol + Lignocaine + Betamethasone + Clotrimazole + Ofloxacin + Antipyrine |   137 | Zinc Carnosine + Sucralfate                                                                                                                      |
|   113 | Ofloxacin + Clotrimazole + Betamethasone + Lignocaine                                |   138 | Mebeverine Hydrochloride &Inner HPMC capsule (Streptococcus Faecalis +Clostridium Butyricum + Bacillus Mesentricus + Lactic Acid Bacillus)       |
|   114 | Gentamicin Sulphate + Clotrimazole + Betamethasone + Lignocaine                      |   139 | Clindamycin + Clotrimazole + Lactic Acid Bacillus                                                                                                |
|   115 | Clotrimazole + Beclomethasone + Ofloxacin + Lignocaine                               |   140 | Sildenafil + Estradiol Valerate                                                                                                                  |
|   116 | Beclomethasone + Clotrimazole + Chloramphenicol + Gentamycin + Lignocaine Ear drops  |   141 | Clomifene Citrate + Ubidecarenone + Zinc + Folic Acid + Methylcobalamin + Pyridoxine + Lycopene + Selenium + Levocarnitine Tartrate + L-Arginine |
|   117 | Flunarizine + Paracetamol + Domperidone                                              |   142 | Thyroxine + Pyridoxine + Folic Acid                                                                                                              |
|   118 | Rabeprazole + Zinc Carnosine                                                         |   143 | Gentamycin + Dexamethasone + Chloramphenicol + Tobramycin + Ofloxacin                                                                            |
|   119 | Magaldrate + Famotidine + Simethicone                                                |   144 | Dextromethorphan + Levocetirizine + Phenylephrine + Zinc                                                                                         |
|   120 | Cyproheptadine + Thiamine                                                            |   145 | Nimesulide + Loratadine + Phenylephrine + Ambroxol                                                                                               |
|   121 | Magaldrate + Ranitidine + Pancreatin + Domperidone                                   |   146 | Bromhexine +Phenylephrine + Chlorpheniramine Maleate                                                                                             |
|   122 | Ranitidine + Magaldrate + Simethicone                                                |   147 | Dextromethorphan + Bromhexine + Guaiphenesin                                                                                                     |
|   123 | Magaldrate + Papain+ Fungal Diastase + Simethicone                                   |   148 | Paracetamol + Loratadine + Phenylephrine + Dextromethorphan + Caffeine                                                                           |
|   124 | Rabeprazole + Zinc + Domperidone                                                     |   149 | Nimesulide + Phenylephrine + Caffeine + Levocetirizine                                                                                           |

|   125 | Famotidine + Oxetacaine + Magaldrate                                                             |   150 | Azithromycin + Acebrophylline                                                  |
|-------|--------------------------------------------------------------------------------------------------|-------|--------------------------------------------------------------------------------|
|   151 | Diphenhydramine +Terpine + Ammonium Chloride + Sodium Chloride + Menthol                         |   176 | Diethylcarbamazine Citrate + Cetirizine + Guaiphenesin                         |
|   152 | Nimesulide + Paracetamol + Cetirizine + Phenylephrine                                            |   177 | Pseudoephedrine + Dextromethorphan + Cetirizine                                |
|   153 | Paracetamol+ Loratadine + Dextromethorphan + Pseudoephedrine + Caffeine                          |   178 | Chlorpheniramine + Phenylephrine + Dextromethorphan + Menthol                  |
|   154 | Chlorpheniramine Maleate + Ammonium Chloride + Sodium Citrate                                    |   179 | Ambroxol + Terbutaline + Dextromethorphan                                      |
|   155 | Cetirizine + Phenylephrine + Paracetamol + Zinc Gluconate                                        |   180 | Dextromethorphan + Chlorpheniramine + Guaiphenesin                             |
|   156 | Ambroxol + Guaiphenesin + Ammonium Chloride + Phenylephrine + Chlorpheniramine Maleate + Menthol |   181 | Terbutaline +Bromhexine + Guaiphenesin + Dextromethorphan                      |
|   157 | Dextromethorphan + Bromhexine + Chlorpheniramine Maleate + Guaiphenesin                          |   182 | Dextromethorphan + Triprolidine + Phenylephrine                                |
|   158 | Levocetirizine + Ambroxol + Phenylephrine + Guaiphenesin                                         |   183 | Paracetamol + Dextromethorphan + Chlorpheniramine                              |
|   159 | Dextromethorphan + Chlorpheniramine + Chlorpheniramine Maleate                                   |   184 | Pholcodine + Phenylephrine + Promethazine                                      |
|   160 | Cetirizine + Ambroxol + Guaiphenesin + Ammonium Chloride+ Phenylephrine + Menthol                |   185 | Codeine + Levocetirizine + Menthol                                             |
|   161 | Chlorpheniramine + Phenylephrine + Caffeine                                                      |   186 | Dextromethorphan + Ambroxol + Guaifenesin + Phenylephrine + Chlorpheniramine   |
|   162 | Dextromethorphan + Triprolidine + Phenylephrine                                                  |   187 | Cetirizine + Phenylephrine + Dextromethorphan + Menthol                        |
|   163 | Terpin Hydrate+ Dextromethorphan + Menthol                                                       |   188 | Roxithromycin + Serratiopeptidase                                              |
|   164 | Dextromethorphan + Phenylephrine + Zinc Gluconate+ Menthol                                       |   189 | Paracetamol + Phenylephrine + Triprolidine                                     |
|   165 | Chlorpheniramine + Codeine + Sodium Citrate + Menthol syrup                                      |   190 | Acetaminophen + Loratadine + Ambroxol + Phenylephrine                          |
|   166 | Enrofloxacin + Bromhexine                                                                        |   191 | Cetirizine + Acetaminophen + Dextromethorphan + Phenylephrine + Zinc Gluconate |
|   167 | Bromhexine + Dextromethorphan + Phenylephrine + Menthol                                          |   192 | Diphenhydramine + Guaifenesin + Bromhexine + Ammonium Chloride + Menthol       |
|   168 | Levofloxacin + Bromhexine                                                                        |   193 | Cetirizine + Dextromethorphan + Zinc Gluconate + Menthol                       |
|   169 | Levocetirizine + Ranitidine                                                                      |   194 | Paracetamol + Phenylephrine + Desloratadine + Zinc Gluconate + Ambroxol        |

|   170 | Levocetirizine + Phenylephrine + Ambroxol + Guaiphenesin + Paracetamol                 |   195 | Levocetirizine + Montelukast + Acebrophylline                             |
|-------|----------------------------------------------------------------------------------------|-------|---------------------------------------------------------------------------|
|   171 | Cetirizine + Dextromethorphan + Phenylephrine + Zinc Gluconate + Paracetamol + Menthol |   196 | Dextromethorphan + Phenylephrine + Ammonium Chloride + Menthol            |
|   172 | Paracetamol+ Pseudoephedrine + Dextromethorphan + Cetirizine                           |   197 | Dextromethorphan +Bromhexine +Guaiphenesin + Menthol                      |
|   173 | Diphenhydramine + Guaiphenesin + Ammonium Chloride + Bromhexine                        |   198 | Acrivastine + Paracetamol + Caffeine + Phenylephrine                      |
|   174 | Chlorpheniramine + Dextromethorphan + Phenylephrine + Paracetamol                      |   199 | Naphazoline + Carboxymethyl Cellulose + Menthol + Camphor + Phenylephrine |
|   175 | Dextromethorphan + Promethazine                                                        |   200 | Dextromethorphan + Cetirizine                                             |
|   201 | Nimesulide + Paracetamol + Levocetirizine + Phenylephrine + Caffeine                   |   226 | Cetirizine + Dextromethorphan + Phenylephrine + Tulsi                     |
|   202 | Terbutaline + Ambroxol + Guaiphenesin + Zinc + Menthol                                 |   227 | Cetirizine + Phenylephrine + Paracetamol + Ambroxol + Caffeine            |
|   203 | Codeine + Chlorpheniramine + Alcohol Syrup                                             |   228 | Guaifenesin + Dextromethorphan                                            |
|   204 | Dextromethorphan + Phenylephrine + Guaifenesin + Triprolidine                          |   229 | Levocetirizine + Paracetamol + Phenylephrine + Caffeine                   |
|   205 | Diethylcarbamazine + Cetirizine + Ambroxol                                             |   230 | Ketotifen +Levocetirizine                                                 |
|   206 | Ethylmorphine + Noscapine + Chlorpheniramine Maleate                                   |   231 | Paracetamol + Levocetirizine + Phenylephrine + Zinc Gluconate             |
|   207 | Cetirizine + Dextromethorphan + Ambroxol                                               |   232 | Paracetamol + Phenylephrine +Triprolidine + Caffeine                      |
|   208 | Ambroxol + Guaifenesin + Phenylephrine + Chlorpheniramine                              |   233 | Caffeine + Paracetamol + Phenylephrine + Cetirizine                       |
|   209 | Paracetamol +Phenylephrine + Chlorpheniramine + Zinc Gluconate                         |   234 | Dextromethorphan + Phenylephrine + Guaifenesin                            |
|   210 | Dextromethorphan + Phenylephrine + Cetirizine +Paracetamol + Caffeine                  |   235 | Ambroxol + Levocetirizine + Phenylephrine + Guaiphenesin + Menthol        |
|   211 | Levocetirizine + Dextromethorphan + Zinc                                               |   236 | Pseudoephedrine + Cetirizine                                              |
|   212 | Paracetamol + Phenylephrine + Levocetirizine + Caffeine                                |   237 | Dextromethorphan + Chlorpheniramine + Ammonium Chloride + Menthol         |
|   213 | Chlorpheniramine + Ammonium Chloride + Sodium Chloride                                 |   238 | Paracetamol + Caffeine + Phenylephrine + Chlorpheniramine                 |
|   214 | Paracetamol + Dextromethorphan + Bromhexine + Phenylephrine + Diphenhydramine          |   239 | Salbutamol + Aminophylline + Guaifenesin                                  |
|   215 | Salbutamol + Bromhexine + Guaiphenesin + Menthol                                       |   240 | Salbutamol +Theophylline + Bromhexine                                     |
|   216 | Chlorpheniramine + Ammonium Chloride + Noscapine + Sodium Citrate                      |   241 | Chlorpheniramine + Dextromethorphan + Guaifenesin + Phenylephrine         |
|   217 | Cetirizine + Dextromethorphan + Bromhexine + Guaifenesin                               |   242 | Caffeine + Paracetamol + Chlorpheniramine                                 |

|   218 | Diethylcarbamazine + Chlorpheniramine + Guaifenesin                                        |   243 | Ammonium Chloride + Dextromethorphan + Cetirizine +Menthol                                                                                |
|-------|--------------------------------------------------------------------------------------------|-------|-------------------------------------------------------------------------------------------------------------------------------------------|
|   219 | Ketotifen + Cetirizine                                                                     |   244 | Dextromethorphan +Paracetamol + Cetirizine + Phenylephrine                                                                                |
|   220 | Terbutaline +Bromhexine + Etofylline                                                       |   245 | Chlorpheniramine +Terpin + Antimony Potassium Tartrate + Ammonium Chloride + Sodium Citrate + Menthol                                     |
|   221 | Ketotifen + Theophylline                                                                   |   246 | Terbutaline Sulphate + Etofylline + Ambroxol                                                                                              |
|   222 | Ambroxol + Salbutamol + Theophylline                                                       |   247 | Paracetamol + Codeine + Chlorpheniramine                                                                                                  |
|   223 | Cetirizine + Nimesulide + Phenylephrine                                                    |   248 | Paracetamol + Pseudoephedrine + Cetirizine +Caffeine                                                                                      |
|   224 | Chlorpheniramine + Phenylephrine + Paracetamol + Zinc Gluconate                            |   249 | Chlorpheniramine + Ammonium Chloride + Menthol                                                                                            |
|   225 | Acetaminophen + Guaifenesin + Dextromethorphan + Chlorpheniramine                          |   250 | N-Acetyl Cysteine + Ambroxol + Phenylephrine + Levocetirizine                                                                             |
|   251 | Dextromethorphan + Phenylephrine +Triprolidine + Menthol                                   |   276 | Guaifenesin + Bromhexine + Chlorpheniramine + Phenylephrine + Paracetamol + Serratiopeptidase (as enteric coated granules) 10000 SP Units |
|   252 | Salbutamol + Cetirizine +Ambroxol                                                          |   277 | Paracetamol + Pheniramine                                                                                                                 |
|   253 | Dextromethorphan + Phenylephrine + Bromhexine + Guaifenesin + Chlorpheniramine             |   278 | Betamethasone + Fusidic Acid + Gentamycin + Tolnaftate + Iodochlorhydroxyquinoline (ICHQ)                                                 |
|   254 | Nimesulide + Cetirizine + Phenylephrine                                                    |   279 | Clobetasol + Ofloxacin + Miconazole + Zinc Sulphate                                                                                       |
|   255 | Naphazoline + Chlorpheniramine +Zinc Sulphate + Boric Acid + Sodium Chloride + Chlorobutol |   280 | Clobetasol + Gentamicin + Miconazole + Zinc Sulphate                                                                                      |
|   256 | Dextromethorphan + Phenylephrine + Guaifenesin + Cetirizine + Acetaminophen                |   281 | Levocetirizine + Ambroxol + Phenylephrine + Paracetamol                                                                                   |
|   257 | Guaifenesin + Bromhexine + Chlorpheniramine + Paracetamol                                  |   282 | Permethrin + Cetrimide + Menthol                                                                                                          |
|   258 | Chlorpheniramine + Ammonium Chloride + Chloroform + Menthol                                |   283 | Beclomethasone + Clotrimazole + Neomycin + Iodochlorohydroxyquinone                                                                       |
|   259 | Salbutamol + Choline Theophyllinate + Ambroxol                                             |   284 | Neomycin + Doxycycline                                                                                                                    |
|   260 | Pseudoephedrine + Bromhexine                                                               |   285 | Ciprofloxacin + Fluocinolone + Clotrimazole + Neomycin + Chlorocresol                                                                     |
|   261 | Cetirizine + Phenylephrine + Paracetamol + Caffeine + Nimesulide                           |   286 | Clobetasol + Ofloxacin + Ketoconazole + Zinc Sulphate                                                                                     |
|   262 | Dextromethorphan + Cetirizine + Guaifenesin + Ammonium Chloride                            |   287 | Betamethasone + Gentamicin + Tolnaftate + Iodochlorhydroxyquinoline                                                                       |
|   263 | Ambroxol + Salbutamol + Choline Theophyllinate + Menthol                                   |   288 | Clobetasol + Gentamicin + Tolnaftate + Iodochlorohydroxyquinone + Ketoconazole                                                            |
|   264 | Paracetamol + Chlorpheniramine + Ambroxol + Guaifenesin + Phenylephrine                    |   289 | Allantoin + Dimethicone + Urea + Propylene + Glycerin + Liquid paraffin                                                                   |

|   265 | Chlorpheniramine + Vasaka + Tolu Balsam + Ammonium Chloride + Sodium Citrate + Menthol   |   290 | Acriflavine + Thymol + Cetrimide                                                                                 |
|-------|------------------------------------------------------------------------------------------|-------|------------------------------------------------------------------------------------------------------------------|
|   266 | Bromhexine + Cetirizine + Phenylephrine IP + Guaifenesin + Menthol                       |   291 | Betamethasone + Neomycin + Tolnaftate + Iodochlorhydroxyquinoline + Chlorocresol                                 |
|   267 | Dextromethorphan + Ambroxol + Ammonium Chloride +Chlorpheniramine + Menthol              |   292 | Clobetasol + Neomycin + Miconazole + Clotrimazole                                                                |
|   268 | Dextromethorphan + Phenylephrine + Cetirizine + Zinc + Menthol                           |   293 | Ketoconazole + Tea Tree Oil + Allantion + Zinc Oxide + Aloe Vera + Jojoba Oil + Lavender Oil + Soap Noodles      |
|   269 | Terbutaline + N-Acetyl L-Cysteine + Guaifenesin                                          |   294 | Clobetasol Propionate + Ofloxacin + Ornidazole + Terbinafine                                                     |
|   270 | Calcium Gluconate + Levocetirizine                                                       |   295 | Clobetasol + Neomycin + Miconazole + Zinc Sulphate                                                               |
|   271 | Paracetamol + Levocetirizine + Pseudoephedrine                                           |   296 | Beclomethasone Dipropionate + Neomycin + Tolnaftate + Iodochlorhydroxyquinoline + Chlorocresol                   |
|   272 | Salbutamol + Choline Theophyllinate + Carbocisteine                                      |   297 | Betamethasone + Gentamycin + Zinc Sulphate + Clotrimazole + Chlorocresol                                         |
|   273 | Chlorpheniramine + Vitamin C                                                             |   298 | Borax + Boric acid + Naphazoline + Menthol + Camphor + Methyl Hydroxybenzoate                                    |
|   274 | Calcium Gluconate + Chlorpheniramine +Vitamin C                                          |   299 | Bromhexine + Dextromethorphan                                                                                    |
|   275 | Chlorpheniramine + Paracetamol + Pseudoephedrine + Caffeine                              |   300 | Dextromethorphan + Chlorpheniramine + Bromhexine                                                                 |
|   301 | Menthol + Anesthetic Ether                                                               |   315 | Beclomethasone + Clotrimazole + Gentamicin + Iodochlorhydroxyquinoline                                           |
|   302 | Dextromethorphan + Chlorpheniramine + Ammonium Chloride + Sodium Citrate + Menthol       |   316 | Telmisartan + Metformin                                                                                          |
|   303 | Ergotamine Tartrate + Belladona Dry Extract + Caffeine + Paracetamol                     |   317 | Ammonium Citrate + Vitamin B 12 + Folic Acid + Zinc Sulphate                                                     |
|   304 | Gliclazide 40 mg + Metformin 400 mg                                                      |   318 | Levothyroxine + Pyridoxine + Nicotinamide                                                                        |
|   305 | Paracetamol + Ambroxol + Phenylephrine + Chlorpheniramine                                |   319 | Benfotiamine + Metformin                                                                                         |
|   306 | Oflaxacin + Ornidazole suspension                                                        |   320 | Thyroid + Thiamine + Riboflavin + Pyridoxine + Calcium Pantothenate + Tocopheryl Acetate + Nicotinamide          |
|   307 | Albuterol + Etofylline + Bromhexine + Menthol                                            |   321 | Ascorbic Acid + Manadione Sodium Bisulphate + Rutin + Dibasic Calcium Phosphate + Adrenochrome Monosemicarbazone |
|   308 | Albuterol + Bromhexine + Theophylline                                                    |   322 | Phenylephrine + Chlorpheniramine + Paracetamol + Bromhexine + Caffeine                                           |
|   309 | Salbutamol + Hydroxyethyl Theophylline (Etofylline) + Bromhexine                         |   323 | Clotrimazole + Beclomethasone + Lignocaine + Ofloxacin + Acetic Acid + Sodium Methylparaben + Propylparaben      |

|   310 | Paracetamol + Phenylephrine + Levocetirizine + Sodium Citrate   |   324 | Nimesulide + Levocetirizine      |
|-------|-----------------------------------------------------------------|-------|----------------------------------|
|   311 | Paracetamol + Propyphenazone + Caffeine                         |   325 | Ofloxacin + Ornidazole Injection |
|   312 | Guaifenesin + Diphenhydramine + Bromhexine + Phenylephrine      |   326 | Gemifloxacin + Ambroxol          |
|   313 | Dried Aluminium Hydroxide Gel + Propantheline + Diazepam        |   327 | Glucosamine + Ibuprofen          |
|   314 | Bromhexine + Phenylephrine + Chlorpheniramine + Paracetamol     |   328 | Etodolac + Paracetamol           |

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