Lok Sabha Question No. 869 (UNSTARRED), answered on 2021-02-05
Subject: Target for the Council of Scientific  and Industrial Research
Ministry: SCIENCE AND TECHNOLOGY
Asked by: Hemant Tukaram Godse

## GOVERNMENT OF INDIA MINISTRY OF SCIENCE AND TECHNOLOGY DEPARTMENT OF SCIENTIFIC AND INDUSTRIAL RESEARCH

## LOK SABHA UNSTARRED QUESTION NO. 869 (TO BE ANSWERED ON 05.02.2021)

## TARGET FOR THE COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

## 869.  SHRI HEMANT TUKARAM GODSE:

Will  the  Minister of  SCIENCE AND  TECHNOLOGY विज्ञान एिं प्रौद्योगिकी मंत्री be pleased to state:

- (a)   whether the Government has set any target for the Council of Scientific and Industrial Research (CSIR) in the field of research and development;
- (b) if so, the details thereof and the achievements made by the CSIR till date;
- (c)  the  number and details of projects taken up by the CSIR for progress and development of the country during last three years; and
- (d) the total funds allocated and spent by CSIR during the last three years and the current year?

## ANSWER

## MINISTER OF HEALTH AND FAMILY WELFARE; MINISTER OF SCIENCE AND TECHNOLOGY; AND MINISTER OF EARTH SCIENCES

## (DR. HARSH VARDHAN)

- (a) Yes Sir. Council of Scientific and Industrial Research (CSIR) is positioned to  undertake  research  and  development  focused  at  the  unmet  need  and deliver  knowledgebase/  technology  to  benefit  the  masses  and  Indian industry.  CSIR  has  been  pursuing  diverse  Scientific  and  Technological activities and thus has been delivering as per national priorities.
- (b) The major recent achievements /initiatives of CSIR are given in
- Annexure - I.
- (c) Research & Development activities are being pursued by CSIR in following categories of projects namely: (i) Fast Track Translation (FTT) Projects; (ii)  Fast  Track  Commercialization  (FTC)  Projects;  (iii)  Mission  Mode Projects;  (iv)  Focused  Basic  Research  (FBR)  Projects;  and  (v)  Niche

Creating  High  Science/  High  Technology  (NCP)  Projects.  These  are grouped into eight themes: (i) Aerospace, Electronics, Instrumentation & Strategic Sectors (AEISS); (ii) Civil, Infrastructure & Engineering (CIE); (iii) Ecology,  Environment  Earth  &  Ocean  Sciences  and  Water  (E3OW);  (iv) Mining,  Minerals,  Metals  and  Materials  (4M);  (v)  Chemicals  (including leather)  and  Petrochemicals  (CIP);  (vi)  Energy  (Conventional  &  NonConventional)  and  Energy  Devices  (EED);  (vii)  Agri.,  Nutrition  &  Biotech (ANB);  and  (viii)  Healthcare  (HTC).  Further,  CSIR  is  also  implementing projects  under  New  Millennium  Indian  Technology  Leadership  Initiative (NMITLI),  Harnessing  Appropriate  Rural  Interventions  and  Technologies (HARIT) and Fundamental & Innovative Research in Science of Tomorrow (CSIR-FIRST) categories. The  number  of  projects with their details implemented  during  last  three  years  and  under  implementation  during current financial year is attached at Annexure-II.

## (d) The total funds allocated and spent for CSIR during the last three years and the current year is as follows:

| Financial Year              | Funds Allocated / Spent (Rs in Crore)      |
|-----------------------------|--------------------------------------------|
| 2017-18                     | 4582.12                                    |
| 2018-19                     | 4521.28                                    |
| 2019-20                     | 4831.58                                    |
| 2020-21 (Revised Estimates) | 4251.86 3914.06 (spent up to January, 2021 |

*****

## Major recent achievements/initiatives of CSIR

## Indigenous Cultivation of Heeng to reduce imports

Ferula assafoetida (Heeng) one of the top spices in India is imported from Iran, Afghanistan, and Uzbekistan and  spends  ~100-130  million  USD  per  year.  CSIR-Institute  of  Himalayan  Bioresource  Technology, Palampur (CSIR-IHBT), along with ICAR-National Bureau of Plant Genetic Resources, has addressed the lack of planting material and agrotechnology, which were major bottlenecks in cultivation. Now the plants have been introduced for cultivation in the country with the first seedlings of heeng panted at Lahaul valley after the Institute successfully conducted experiments with plants and seed germination. Cold desert areas of India  such  as  Lahaul  and  Spiti,  Ladakh,  parts  of  Uttarakhand  and  Arunachal  Pradesh  are  suitable  for cultivation of asafetida and can decrease the imports of Heeng substantially after successful cultivation.

## India's First Hydrogen Fuel Cell Prototype Car

CSIR and industry partner KPIT successfully ran trials of India's Hydrogen Fuel Cell (HFC) prototype car running on an indigenously developed fuel cell stack. CSIR and KPIT have successfully developed a 10kWe automotive grade LT-PEMFC fuel cell stack based on CSIR's know-how. The heart of the (Proton Exchange Membrane) PEM fuel cell technology includes the membrane electrode assembly, which is wholly a CSIR knowhow. Hydrogen Fuel Cell (HFC) technology  uses  chemical  reactions  between  hydrogen  and  oxygen (from air) to generate electrical energy. This is a boost for renewable energy based on the hydrogen as fuel, which is the cleanest fuel and will also reduce the petrol, and diesel imports.

## Wax Deoiling Technology at Numaligarh Refinery, BPCL

CSIR- Indian Institute of Petroleum (CSIR-IIP), Dehradun, in association with the Engineers India Ltd (EIL) had  won  international  competition  to  adopt  the  Wax  Deoiling  Technology  developed  by  CSIR-IIP,  at Numaligarh Refinery Ltd (NRL). The Wax Deoiling Plant based on such indigenously developed technology was set up with an investment of ₹750 crore at NRL - a subsidiary of Bharat Petroleum Corporation Limited (BPCL)  -  situated  in  north-east  part  of  India.  The  Plant  was  dedicated  to  the  Nation  by  Hon'ble  Prime Minister in February 2016. The Wax Deoiling technology is used to produce waxes from petroleum streams. This  newly  set  up  plant  will  produce  50,000  MMTPA  of  high  value  Paraffin  Wax  and  4,500  MTPA  of Microcrystalline  Wax  that  will  help  cut  down  the  wax  import  by  50  per  cent  and  will  save  the  foreign exchange of about 500 crore rupees/annum. The wax plant will help to develop small-scale ancillaries and cottage industries  in  the  nearby  areas  and  will  promote  industrial  development  in  the  north-east  region  of India. The commercialization of indigenous technology is in line with 'Make in India' initiative taken by the Government of India.

## CHENANI-NASHRI Highway Tunnel Project

The Chenani - Nashari tunnel project was completed in March 2017 and was dedicated to the nation in April 2017  by  Hon'ble  Prime  Minister  of  India.    CSIR-CIMFR  has  contributed  in  a  significant  way  in  this Highway Tunnel Project.

## Establishment of a National Calibration Facility for PM1, PM2.5 and PM10 Sampling Inlets

A particulate matter (PM) wind-tunnel has been established at CSIR-NPL. This is a first and unique facility in  the  country  to  test  and  calibrate  PM1,  PM2.5  and  PM10  samplers.  With  this  facility,  now  all  the  PM samplers manufactured in the country can be calibrated and certified. Also, all the imported PM samplers can be tested for their suitability under Indian conditions. Parameters such as cut-off size, sharpness of cut-off

etc. can be tested and calibrated by using this facility. A high-volume PM2.5 sampler, has been developed and patented by CSIR-NPL. The technology has been transferred to M/s Environmental Solutions.  Hon'ble Minister  of  S&T  and  Earth  Sciences  Dr.  Harsh  Vardhan  inaugurated  the  indigenously  developed  and commercialized  high-volume  sampler  by  the  M/s  Environmental  Solutions  under  the  licensed  technology (know-how) of CSIR-NPL patented technology.

## State-of-the-art WHO cGMP Plant at CSIR-IIIM, Jammu

State-of-the-art  WHO  cGMP  Plant  has  been  set  up  at  CSIR-IIIM,  Jammu  for  extraction,  formulation, packaging  of  medicinal  plant  based  phytopharmaceutical  drugs  under  internationally  accepted  GMP guidelines. This is first such national cGMP facility established in the public sector in India. The facility has been in  making  for  last  5  years,  completed  in  2016  and  issued  a  manufacturing  license  by  Drug  &  Food Control Organization, Jammu & Kashmir.

## First of its Kind 'Waste Management Park' Built

CSIR-NEERI has established first of its kind Waste Management Park to Nagpur. The main focus of the park is to make people aware of effective waste management by reducing, reusing, recycling and segregating the waste; the park is itself a desirable model for depicting how well waste can be converted into useful products. The Waste Management Park exhibits how waste can be managed, reduced and beautified. The park has two huts that serve as a learning centre about how different kinds of wastes like hazardous waste, Construction and Demolition (C&D) waste, biomedical/reject waste, etc. can be treated and recycled and simultaneously highlight what a citizen can do to minimize waste generation.

## CSIR Aroma Mission

The  CSIR  Aroma  Mission  is  envisaged  to  bring  transformative  change  in  the  aroma  sector  through development of superior aroma crop varieties and their agro-technologies and assessment of their suitability for the large scale cultivation in specific agro-climatic regions; promotion of cultivation and processing of aromatic crops, enhancing area under selected aromatic crops along with enabling interventions including setting up of distillation units and catalyzing setting up of cooperatives for marketing of the produce; valueaddition of aromatic crops in the form  of high-end aroma  chemicals  and  products; and skill  & entrepreneurship activities and facilitating the creation of Spin-offs.  In the first phase of the project, an area of  more  than  6000  hectares  has  been  brought  under  cultivation  of  aromatic  plants  across  the  country. Aromatic crops  cultivation  has  been  promoted  in  46  Aspirational  Districts  under  the  Aroma  Mission  and about  1014  hectare  area  was  brought  under  cultivation  in  these  districts.  In  the  765  training  /  workshops conducted throughout the country, over 44,000 persons were trained in different aspects of cultivation and processing technologies. Processing of the harvest in 231 distillation units installed under the project, has yielded over 500 tonnes essential oil worth about Rs 57.04 crore for the farmers. The next phase of CSIR Aroma  Mission  is  envisaged  to  bring  a  real  transformative  change  in  the  aroma  sector  through  desired scientific  interventions  in  the  areas  of  agriculture,  processing  and  product  development  for  fuelling  the growth  of  aroma  industry  and  rural  employment.  The  focus  would  be  on  the  utilization  of  waste  and underutilized lands, multi-tier cropping system and integration with other crops.

## CSIR Floriculture Mission

In  India,  CSIR  has  been  in  the  forefront  of  developing  floricultural  crop  varieties  and  has  been  a  major developer of  agrotechnologies for several floriculture crops including Gladiolus, Canna,  Carnation, Bougainvillea,  Chrysanthemum,  Gerbera,  Lilium,  Marigold,  Rose,  Tuberose,  Strelitzia,  Alstromeria  and Hippeastrum.  CSIR,  in  collaboration  with  Ministry  of  MSME  (FFDC,  KVIC),  Ministry  of  Agriculture (ICAR), Ministry of Tribal Affairs (TRIFED), proposes to enhance the export potential of the floriculture

sector, domesticate the wild floral diversity of the country to popularize them as global ornamentals, create employment  opportunities  for  urban  and  rural  youth  through  this  fast  growing  sector,  and  to  provide enhanced income to the farmers up to Rs. 18 lakh per year per hectare to 3800 farmers and generation of 15,58, 188 mandays. Cumulative benefit to farmers and entrepreneurs is expected to be about Rs. 305.77 crore. Expansion of floriculture crops and integration of floriculture with apiculture is expected over 4257 ha spread  in  over  21  states  and  union  territories.  As  a  result,  import  substitution  worth  Rs.  500  crore  of floriculture and fragrant commodities is expected.

## Nano-Biosensors and Microfluidics for Healthcare

The project  was  a  multi-institutional  mission  mode  initiative  of  CSIR  aligning  with  Government  of  India schemes  of  Swasth  Bharat  and  Make-in-India.  The  achievements  of  the  project  included  development  of Handheld Raman Spectrometer; successful detection of breast cancer biomarkers in tissue samples using two approaches; optical detection of typhoid biomarkers;  successful testing for dengue  detection using fluorescence method; Point-of-Care GaN HEMT based platform device realized and tested for biomarker like HER2  and  C3G;  and  a  microfluidic  platform  realized  for  electrochemical  detection  of  biomarkers  using unique marker concentration technique, making it suitable for early detection applications.

## Innovative Processes and Technologies for Agrochemicals

The Indian agrochemical industry is mainly dependent on import of key intermediates and active ingredients. Hence, CSIR Agrochemical Mission focused on process development of key intermediates and final active crop  protection  molecules  for  indigenous  use.  Main  aim  and  objective  of  this  project  was  to  develop innovative and novel processes for 12 molecules (Flubendiamide, Prothioconazole, Tembotrione, Pyroxasulfone Penflufen, Picoxystrobin, Penoxasulam, Flonicamid, Spirotetramat, Pymetrozine, Epoxiconazole, Glufosinate) that are soon to be generic and nationally important. The processes for these 12 molecules  were  developed  at  lab  scale.  Among  them,  three  molecules  (Flubendiamide,  Tembotrione, Flonicamid) were taken for process scale up in Kg level. One molecule, Glufosinateis licensed to an Indian agrochemical firm.

## Catalysis for Sustainable Development

CSIR-NCL, Pune under the Mission mode project aimed at offering an ultra-clean green fuel to bring down the level of air pollution across the country and providing sustainable mobility to the nation.  An innovative, sustainable and most efficient DME process was developed with the help of indigenous catalytic system and reactor design and the technology developed under the project was dehydration of Methanol to DME . The indigenously developed pilot plant scale reactor could produce 24lit/day of DME, which is the first process developed in India. Through this process, conversion of 80-85% methanol to DME with 98.0% selectivity at 10  bar  in  laboratory  scale  and  semi  pilot  plant  set  for  the  best  catalyst  could  be  achieved.  The  scale  of operation  of  this  process  is  3g,  5g,  50g,  100g,  250g,  and  1000g.  Both  registration  for  burner  and  reactor design  and  patent  for  catalytic  conversions  and  process  have  been  filed.      Dr.  Harsh  Vardhan,  Hon'ble Minister  (S&T,  ES,  H&FW)  had  inaugurated  nation's  first  indigenously  developed  DME  pilot  plant  on September 9, 2019 . NITI Aayog had also given green flag to CSIR-NCL - DME Process and advised to take it to industry scale at 1.5 MTPD. Multiple industries were interested in CSIR-NCL DME process technology which catered to the GoI Missions like 'Make in India' and 'Innovate in India'.

## Sickle Cell Anaemia Mission

Sickle  cell  anaemia  (SCA)  is  the  most  common  blood  related  disorder  in  India  which  predominantly observed  among  ethnic  groups  that  have  a  socio-economic  disadvantage,  such  as  tribal  populations,  etc. Every year approximately 5,00,000 children are born with SCA worldwide with India accounting for nearly

50% of the cases. The overarching goal of the CSIR Mission is to reduce the burden of sickle cell anaemia through  multi-pronged  strategies  that allow  early diagnosis, genetic  risk  prediction  and  appropriate therapeutic and management strategies. Under the Phase I of Sickle Cell Anaemia Mission, implemented by seven  CSIR  laboratories  under  the  leadership  of  CSIR-CCMB,  2  lakh  people  have  been  screened  for  the genetic disease of which 12,000 has been found to be carriers of the disease  and about 700 are  afflicted. Several camps were organized in Chhattisgarh (Bilaspur and Raipur) and Maharashtra (Nagpur) organized under the aegis of CIMS, Bilaspur and GMC, Nagpur for creating awareness about the disease, the screening programme  and  various  options  for  the  affected  and  carrier  individuals  and  treatment  availability.  A hydroxyurea formulation for treatment of SCA patients is being developed to undertake clinical trial. Few herbal  extracts  have  also  found  to  be  effective  in  treatment  of  SCA  and  are  being  worked  upon  for development  of  phytopharmaceutical/nutraceutical  for  SCA.  A  new  Phase  II  Mission  is  being  planned  to undertake development of leads obtained in Phase I.

## Nutraceuticals and Nutritionals Mission

The  Mission  was  implemented  by  ten  CSIR  laboratories  with  CSIR-IHBT  as  Nodal.  Nutraceutical formulations/ products have been developed for bone health, cognition, immunity and sleep disorders, which has given leads and needs final support data of Human Intervention studies and evaluation, before it can go for  commercialization.  Further,  10  region  specific  and  pan  Indian  Dense  and  Nutritious  foods  have  been developed keeping in view of the societal role of CSIR for School children that meet the RDA requirement of nutrients through Food based approach, including scale up ready for installation. These products can be used as specialty food items either in the morning or in the evening and either for children or needy adults. The products are ready at pilot level, and needs setting up of region wise manufacturing plants perhaps in 56 different CSIR laboratories for reach out to Society for multipurpose use.

## Food and Consumer Safety Solutions Mission

The  Mission  was  implemented  by  seven  CSIR  laboratories  with  CSIR-IITR  as  Nodal.  With  the  broad objective of developing technological solutions for food safety, the specific objectives of the Mission were: (i) Developing Sensors and Systems for food safety; (ii) Developing Methods and techniques for food safety; and (iii) Extension and outreach for food safety.  The Mission has led to the development of 16 technologies under  various  paradigm  of  food  safety.  Some  of  the  technologies  have  been  commercialized  and  several others are under different stages of validation for taking up by the industries or regulatory stakeholders.  The Mission has led to creation of ecosystem where CSIR and regulatory body, FSSAI, will work together to bring  affordable  technologies  for  food  safety  and  testing  in  the  market  and  raise  the  awareness  among consumers. An MOU has been signed between CSIR and FSSAI as a result of this Mission.

## Development of Fast, Durable and Energy Efficient Mass Housing Scheme

The project was a multi-institutional mission mode initiative of CSIR aimed to meet the challenges being faced  in  Mass  housing  and  Smart  City  development.  For  this,  a  considerable  leap  in  knowledge  in  many disciplines  of  engineering,  architecture,  urban,  rural  &  regional  planning,  social  sciences  and  information technology is required.  Therefore this mission mode project was developed under the unified  umbrella of CSIR,  with  the  explicit  purpose  to  bridge  the  gap  in  practice  through  innovation,  with  well-conceived objectives and distinct deliverables. The achievements of the project included development of Large panel precast elements for walls and floors using different materials such as EPS, Steel-foam concrete composite, self-flowing concrete-steel composites etc;  design and development of joints for interlocking wall to wall, wall to floor and floor to floor panels and evaluating the joint efficiency; development of Precast foundation, beam,  columns  and  staircase;  Fabrication  and  prototype  development  of  plastering  machine  for  walls  in housing construction; Rainwater harvesting system design finalized and site identified for implementation of

the system; development of Mode choice model; Synthesis of eco-friendly corrosion inhibitor and protective coatings; Simulation of spread of smoke and evacuation strategy carried on a G+3 housing unit; Construction of  3  lakhs  houses  under  PMAY-Rural  in  Orissa  state  using  CSIR-CBRI  Technologies  and  installation  of Wind Solar Hybrid (WiSH) systems over Demo building (TDC, CSIR-SERC) have been completed.

## CSIR Innovation Centre for Next Generation Energy Storage Solutions [LIB Lithium Ion Battery]

Every month, 10 million Lithium-Ion Battery Cells are being imported to India from countries like China, South Korea, and Japan. In a step towards self-reliance and to cut the dependence on imports, the Council of Scientific  &  Industrial  Research  (CSIR)  is  making  CSIR-Innovation  Centre  for  Next  Generation  Energy Storage Facility. This facility will be the first one in India to demonstrate the Lithium battery fabrication up to 100 Mega Watt capacities. Lithium battery manufacturing is a capital and operation expenditure intensive industry which is typically about Rs. 800-1000 Cr for Giga-watt plant and India's requirement for batteries is several  hundreds  of  Giga-watts.  This  Innovation  Center  would  help  the  Indian  industry  to  come  up  with Lithium battery fabrication facilities with environment-friendly, cost-effective, and energy-efficient technology.  It will pave the way for industries to fabricate and develop their cells and validate before they establish the manufacturing plant saving on cost and time. Also, this will cater to the needs of some of the crucial  requirements  for  strategic  sector  applications.    This  facility  will  enable  the  fabrication  of  5  Ah cylindrical  and  20  Ah  capacity  prismatic  cells.  The  facility  CSIR  is  building  will  exclusively  work  on Indigenous  Li-ion  battery  technology  and  also  leapfrog  next-generation  technologies  such  as  Sodium-ion, Lithium-sulfur  batteries,  and  Solid-state  batteries.  Tata  Chemicals  Limited  has  been  chosen  as  industry partner to help run the facility.

## Development  of  Advanced  Materials  and  Devices  for  Opto-electronic,  Biomedical  and  Strategic Applications

The mission project aims to develop new materials and undertake the associate research required to mature their application in the deliverable device / prototype / product for cutting edge applications, by the cohesive multidisciplinary  R&D  efforts  of  CSIR  laboratories.  It  is  specifically  focused  on  advanced  optoelectronic materials, meta-materials, bio-implants, and un-conventional composite materials and their device development, which is expected to make a big technological intervention and their outcome, can set forth the translational outcome in the subsequent years to come. The multifaceted outcome of the project will lead to many  technologies  for  optoelectronic,  healthcare  (e-skin),  bio-implant,  armor,  automobile,  and  other applications. All of these technologies will immensely contribute to the self-reliance of the nation and have good market potential. The project is led by CSIR-IMMT, Bhubaneswar.

## Bulk Chemicals Mission

Globally, bulk chemicals are the most traded chemicals (in terms of volume) and are the building blocks for a host  of  products.    With  the  increase  in  industrial  activities,  the  demand  for  chemicals  has  also  increased, which has resulted in higher international trade. Through the mission project on Bulk Chemicals, CSIR has pitched in with its diversified expertise and portfolio, thereby, generating a knowledgebase in the area of bulk chemical production. The project is led by CSIR-NCL, Pune, and focuses on the development of technology for production of Lithium from ores; Critical metals from used Li-ion battery; Propylene Oxide; High-Value Aromatics; Carbon Fibers from Petroleum Pitch Precursors and Coal Resin; DCDA; Cyclohexanone Oxime from Cyclohexanone; and Bisphenol-A.

## Development   of    Processes   for Active    Pharmaceutical   Ingredients  towards COVID - 19

To address the Corona Pandemic, the only immediate option is repurposing the existing drugs, in particular anti-viral agents.  Majority of the drugs are not marketed / available in India and even if available, the key starting  materials  need  to  be  imported.  CSIR  has  taken  up  a  mission  mode  project  with  the  aim  of development  of  cost  effective  and  complete  process  know-how  for  23  selected  API  molecules  to  treat COVID  19.    The  APIs  being  developed  are:  Centhaquin,  Umifenovir,  Tilorone,  Baloxavir,  Saquinavir, Remdesivir, Dalargin, KSMs-Hydroxychloroquine,  Ribavirin, EIDD-1931,  Phosphonate Fragment of Remdesivir,  Barcitinib,  Ruxolitinib,  Lopinavir-KSM,  Ritonavir  -KSM,  EIDD  2801,  and  Galidesvir.    The objectives of the project include development of complete process know-how for these API molecules, inter alia, development of analytical method for key starting materials of the APIs; indigenous and cost effective development of all intermediates and API ' s; demonstration of the know-how process for key intermediates on 500 g scale and  each API on a minimum of 25 g scale; identifying the combination of drugs towards COVID19  through  molecular  modelling  study  and  generating  the  clinical  data  for  combination  of  drugs towards COVID -19 . The project is currently in implementation at CSIR-IICT, Hyderabad along with 8 other constituent laboratories of CSIR for a short duration of nine months.

## Medical Instruments & Devices Mission

This CSIR-Mission Mode Program on 'Medical Instruments & Devices' has been formulated to take lead in the  manufacturing  of  high-end  medical  devices  in  the  country.  High-end  medical  devices  are  mainly manufactured by multinational companies and  mostly imported. In present government policies, the main thrust should be on reducing the import dependency by manufacturing even high technology medical devices in India. The mission will focus on development on (i) Diagnostic & Therapeutic Devices; (ii) Rehabilitation and  Assistive  Technologies  for  Elderly  &  Disabled;  (iii)  Imaging  based  Technologies  for  Medical Application; and (iv) Advanced Manufacturing based Orthopaedic and Dental Implants.

## Demonstration and validation of a 5kW HT-PEMFC based combined cooling and power system

A 5.0 kW Fuel Cell Prototype has been designed, developed and demonstrated based on High Temperature Proton  Exchange  Membrane  (HT-PEM)  Fuel  Cell  Technology.  The  prototype  system  has  majority  of indigenously  developed  components,  especially  indigenous  Graphite  Plates,  Carbon  Paper  and  Membrane Exchange Assembly (MEA). The field trails are under process. The developed system could be most suitable for distributed stationary power applications like; for small offices, commercial units, data centres etc., where highly reliable power is essential with simultaneous requirement for air-conditioning. This system may also meet the requirement of efficient, clean and reliable backup power generator for various applications, like telecom towers, remote locations and strategic applications as well.  Hon'ble President of India unveiled the first  Indigenous High Temperature Fuel Cell System Prototype developed by CSIR in partnership with an Indian industry, M/s Thermax Ltd., Pune on the occasion of CSIR Foundation Day Celebrations at Vigyan Bhawan, New Delhi on September 26, 2019.

## Novel Therapy for Management of Sepsis

In the partnership of M/s Cadila Pharmaceuticals Ltd. and PGI, Chandigarh under a CSIR-NMITLI project, a randomized, double blind, two arms, active comparator controlled, phase IIb clinical trial to study the safety and efficacy  of  Mycobacterium  w  in  combination  with  standard  therapy  versus  standard  therapy  alone  in sepsis due to gram negative infection was undertaken. The clinical trial report was submitted to DCGI which has approved the drug for use. With the success of the trial, Cadila Pharmaceuticals has launched the product, 'Sepsivac'  which  is  poised  to  resolve  the  unmet  medical  need  of  the  world  by  gram  negative  bacterial infections.

## Truenat for Point of care Tuberculosis Detection

The Truenat platform from Molbio Diagnostics is the world's only commercial field usable, battery-operated PCR that can be deployed in resource-limited settings worldwide for rapid, sensitive, and accurate diagnosis of infectious diseases like Corona Virus, TB, Dengue, Chikungunya, H1N1, HCV, HPV, among other tests. The success of the Truelab Platform that does Nucleic Acid Amplification Testing (NAAT) of pathogens is a result of the farsightedness of CSIR in supporting start-ups. CSIR's NMITLI project which started in 2005, helped  in  the  development  of  the  device  involving  Bigtec,  Bangalore;  IISc,  Bangalore;  and  CSIR-IIIM, Jammu. The device was validated for hepatitis-B detection through CSIR-NMITLI Support. Later on DBT, through  the  BIPP  program  helped  with  early  validation  of  select  clinical  parameters.  ICMR's  extensive testing of the platform and suggested modifications for use in the hands of minimally trained technicians has shaped the final product in the market today. This platform is one of India's most widely patented products today,  with  patents  in  over  150  countries.  Indigenous  portable  Truelab  (Molbio  Diagnostics,  India) workstations, previously used and recommended by WHO for tuberculosis are now being used for detection of Covid-19. The performance and accuracy of the Truenat assays have been assessed by FIND in a realworld multicentre diagnostic accuracy study conducted in India, Peru, Ethiopia, and Papua New Guinea. The study  determined  the  diagnostic  accuracy  of  the  Truenat  tests  when  performed  in  peripheral  laboratories, compared  with  culture  as  the  reference  standard.  Alongside  endorsement  by  WHO,  the  Truenat  tests  are listed by the Global Fund to Fight AIDS, Tuberculosis, and Malaria as eligible for procurement, and Truenat MTB, MTB Plus, and MTB Rif have been added to the diagnostics catalog of the Stop TB Partnership's Global Drug Facility (GDF).

## Seaweed Formulations for Productivity and Health of Dairy and Poultry Animals

Under a CSIR-NMITLI Project, CSIR-CSMCRI has developed novel seaweed-based animal feed additive formulations to enhance the productivity of animals, improving the quality of animal products, and boosting immunity. Seaweeds are a rich source of choline, glycine, betaine, nutrients along with biologically active compounds  such  as  fucoidan,  betaine,  and  glucans  which  are  known  to  enhance  animal's  immunity. Polyphenols  in  the  seaweed  exhibit  antioxidant  and  Reactive  Oxygen  Species  (ROS)  scavenging  activity. Seaweed formulations were developed to harness the active ingredients for improving productivity, improved rumen function, boost immunity, and all-round health of animals (cattle and poultry). The formulation was validated  by  the  Indian  Veterinary  Research  Institute  (IVRI),  Central  Avian  Research  Institute  (CARI), National Dairy Research Institute (NDRI), and Toxicity trials done at CSIR-Indian Institute of Toxicology Research (IITR). M/s Aquagri Pvt Processing Ltd was an industrial partner in the project.

## Development of Dental Implants

Under  the  partnership  of  Maulana  Azad  Institute  of  Dental  Sciences  (MAIDS),  Delhi  and  IIT,  Delhi,  an indigenous dental implant has been designed, developed and successfully validated in human clinical trial under CSIR-NMITLI project. The innovation has been granted a US Patent in 2017 and an Indian Patent in 2019.  The  technology  for  Dental  Implants  has  been  transferred  to  M/s  Innvolution  Healthcare  Pvt.  Ltd., Delhi. With the transfer of technology of Dental Implants to Indian Company, M/s Involution Medtech Pvt Ltd (Joint venture of IHPL and Kamal Encon), the country has taken the first step towards 'Make in India' implants and import substituted technology. A dedicated manufacturing, cleaning and packaging setup has been established at  Faridabad.  The industry has obtained the manufacturing license in June 2019 and has commercialized the implants in the name of 'ifix' in India. The developed technology has been appreciated through a letter of commendation by Hon'ble Prime Minister of India.

## India's first biofuel-powered flight: CSIR Technology for Aviation Grade Biofuel

A historic flight powered by indigenously produced aviation biofuel based on patented technology of CSIRIndian  Institute  of  Petroleum  (IIP),  Dehradun  completed  journey  from  Dehradun  to  Delhi  on  August  27, 2018. With this maiden flight India joined the exclusive club of nations using biofuel in aviation. The use of bio  jet  fuel,  apart  from  reducing  greenhouse  gas  emissions  by  about  15  percent  and  Sulfur  Oxides  (SOx) emissions  by  over  99  percent,  is  expected  to  provide  indigenous  jet  fuel  supply  security,  possible  cost savings  as  feedstock  availability  at  farm  level  scales  up,  superior  engine  performance  and  reduced maintenance cost for the airline operators. For the first time in the country, on 26th January 2019, an An-32 transport aircraft of IAF flew with blended bio-jet fuel produced by CSIR technology.

## Successful Inaugural Flight of SARAS PT1N

SARAS  PT1N  (14  seater)  light  transport  aircraft  designed  and  developed  by  CSIR-National  Aerospace Laboratories  (CSIR-NAL)  was  flown  successfully  on  21.02.2018.  The  primary  objective  of  PT1N  is  to evaluate system performance in about 20 flights and the data collected from this shall be used to freeze the design of 19 seater production version aircraft - SARAS MkII.

## Drishti Transmissometer: Deployment across Indian Airports

Drishti is an Indigenous - Innovative -Cost effective visibility measuring system -- First of its type and CSIR is the only organization to have developed this technology in the country. It is useful for airport operations and gives information to pilots on the visibility at the runway. Drishti Transmissometers have been installed at a number of civilian and Indian Airforce airports across the country.

## CSIR Technologies for India's First Light Combat Aircraft  - TEJAS

CSIR  has  been  Integral  Partner  with  ADA  in  Design  and  Development  of  TEJAS.  CSIR  developed  and fabricated 165 composite parts, Fly-by-Wire (FBW) Control Systems and State of art training simulator.

## CSIR signs MoU with Unnat Bharat Abhiyan-Indian Institute of Technology, Delhi(UBA-IITD) and Vijnana Bharti(VIBHA), New Delhi

A Memorandum of Understanding (MoU) was signed between Council of Scientific and Industrial Research (CSIR) New Delhi, Unnat Bharat Abhiyan-Indian Institute of Technology, Delhi(UBA-IITD) and Vijnana Bharti(VIBHA), New Delhi. The MoU is expected to lay the foundation for cooperation and joint action in the  area  of  Unnat  Bharat  Abhiyan  (UBA)  for  rural  development  of  India  through  CSIR  technologies  and related  knowledge  base  in  tune  with  the  people's  aspirations  in  furtherance  of  the  Government  of  India's initiatives like Vijnana Bharati(VIBHA). The Unnat Bharat Abhiyan (UBA) is a flagship national program of the Ministry of Human  Resource Development (MHRD),  Government of India, envisioning the transformational change in rural development processes by leveraging knowledge institutions to help build the  architecture  of  an  Inclusive  India.  The  purpose  of  this  Memorandum  of  Understanding  is  to  provide access to CSIR rural technologies for Unnat Bharat Abhiyan (UBA).

## Indian air quality Interactive Repository or IndAIR launched

CSIR-NEERI, Nagpur launched the Indian air quality Interactive Repository or IndAIR which has archived approximately 700 scanned materials from pre-internet era (1950-1999), 1215 research articles, 170 reports

and  case  studies,  100  cases  and  over  2,000  statues,  to  provide  the  history  of  air  pollution  research  and legislation in the county. Such a repository on the subject of air pollution is one of the first in the world.

## Technology to convert Distillery Waste to Fertilizers

Distilleries generate 10-15 litres of wastewater effluent or 'spent-wash' while producing one litre of alcohol from  fermentation  of  sugarcane  molasses.  There  are  almost  300-odd  molasses-based  distilleries  in  India churning out 2.5-2.6 billion litres of alcohol annually, and in doing so also discharging 30-35 billion litres of spent  wash  having  potential  to  contaminate  surface  and  ground  water.  CSIR-CSMCRI  has  developed  a process  to  separate  the  main  source  of  pollution  -  potash  and  biodegradable  organic  matter  -  from distillery spent-wash. While helping distilleries comply with the Central Pollution Control Board's mandated zero liquid discharge (ZLD) action plans, this technology will also meet up to a tenth of India's potassiumbased fertiliser requirements which is entirely met through imports. CSIR-CSMCRI has filed a patent and has converted the process into a commercial-scale technology in collaboration with Chem Process Systems Private Ltd,  Ahmedabad.  The first full-fledged commercial plant using the technology has been commissioned by Aurangabad Distillery Ltd (ADL) at Walchandnagar, Maharashtra. Plant based on CSIRCSMCRI spent wash technology  commissioned  at  Aurangabad  Distillery  Ltd.  (60  klpd),  Walchandnagar, Maharashtra

## Made in India aviation weather monitoring system installed at Bengaluru International airport

CSIR-NAL has indigenously developed Aviation Weather Monitoring System (AWMS) which has recently been installed at the new runway of Kempegowda International Airport (KIA). With this, KIA has become the  first  airport  in  the  country  to  install  indigenous  AWMS  technology,  at  both  ends  of  the  new  runway. With the web-enabled feature, the data can be accessed, and maintenance carried out from any location. The 10-meter mast on which AWMS sensors are installed is a first-of-its-kind, designed by NAL, with several unique  features,  including  being  eco-friendly  and  lightweight,  with  a  life  of  over  60  years.  The  sliding mechanism enables easy maintenance - a useful feature-considering the busy traffic on the runway.

## Waste Plastics to Fuels

CSIR-IIP  in  collocation  with  and  GAIL  (India)  Ltd  have  developed  a  technology  for  converting  waste plastics to fuel (diesel). After the completion of lab scale and bench scale studies, a demonstration plant of 1 ton per day (TPD) capacity has been set up. The process utilizes waste polyethylene and polypropylene type waste plastics available from MSW and other sources and generates about 800L of diesel per batch. A MoU for  the  technology  to  convert  the  plastic  waste  into  diesel  has  also  been  signed  with  DDA  and  Delhi Municipal Corporation.

## Agreement with Sun Pharma Industries Ltd for licensing of patents on a New Chemical Entity (NCE)

CSIR-IICT  signed  an  agreement  with  Sun Pharma  Industries  Ltd.  for  out  licensing  of  patents on  a  New Chemical Entity (NCE) (Bedaquiline) with potential therapeutic activity across multiple indications in Sun Pharma's specialty focus areas. Under the terms of the license agreement, Sun Pharma gets exclusive global license  for  the  said  patents  and  any  other  future  patents  covered  in  the  agreement.  Sun  Pharma  will  pay CSIR-IICT  upfront  and  potential  development,  regulatory  and  sales  milestone  payments  totaling  up  to Rs.2.40  billion,  plus  royalties  on  net  sales  from  commercialization  of  the  products  developed  using  these patents. Sun Pharma will be responsible for development, regulatory filings, manufacturing and commercialization  of  these  potential  products.  This  agreement  will  facilitate  addition  of  pre-clinical

candidates to Sun Pharma's global specialty pipeline. A successful clinical development of these potential compounds  may  enable  Sun  Pharma  to  commercialize  pharmaceutical  products  for  various  therapeutic indications over the long term.

## Indigenous Process Technology for Carbon Fiber for Aerospace application

Carbon fiber  is  an  excellent  reinforcement  in  structural  composites  used  in  aerospace,  military,  transport, energy  sector,  etc.  Aerospace  grade  carbon  fiber  is  a  monopoly  of  few  countries.  The  availability  of indigenous  carbon  fiber  is  a  must  for  composites,  meeting  specific  requirements  like,  ablative,  structural, braking, thermal shock resistance etc for Indian defense and nuclear programs (development of Intercontinental  Ballistic  Missiles,  Light  Combat  Aircraft,  Advanced  Light  Helicopter,  High  temperature Nuclear Reactor etc).  CSIR- NAL has developed standard modulus grade carbon fiber in pilot scale and demonstrated the process technology to Centre for Military Airworthiness and Certification (CEMILAC) & Directorate General of Aeronautical Quality Assurance (DGAQA). The developed product has been certified by CEMILAC for aerospace application. The carbon fiber developed will benefit the aerospace sector as well as automobile, sports industries, energy sector etc.  Technology know how has been transferred to Bhabha Atomic Research Centre (BARC) on non-exclusive basis.

## Aerospace Grade Autoclave Technology (Industrial and Lab Scale sizes)

Autoclaves  are  used  to  manufacture  airworthy  composite  components  under  suitable  settings  of  pressure, vacuum  and  temperature. CSIR-NAL  has  successfully developed state-of-art Indigenous Autoclave Technology  for  processing  advanced  light  weight  composites  that  are  integral  to  modern  day  civil  and military airframes.  The size of autoclaves developed range from smaller lab scale to very large sizes up to 5m working dia  and  12m  working  length.  The  operating  temperatures  can  be  as  high  as  425  Deg  C  and pressures up to 15 barg.  This will meet the requirements of    Aerospace Industry, Research and Educational Institutes.  The  technology  has  been  transferred  to  two  private  industries.  In  the  last  7-8  years  several autoclaves have been supplied to various organisations in the strategic sector as well as academic institutions. The autoclave technology has been largely successful in promoting the local eco-system, mitigating imports and creating millions of employment man-hours within the country.

## Recycling of E-Waste

E-waste or electronic waste is created when an electronic product is discarded after the end of its useful life. The  rapid  expansion  of technology  the  consumption  driven  society  results  in  the  creation  of  a  very  large amount of e-waste in every minute. Electronic scrap components, such as CPUs, contain potentially harmful materials such as lead, cadmium, beryllium, or brominated flame retardants. Informal processing of e-waste can  lead  to  adverse  human  health  effects  and  environmental  pollution.  Huge  generation  of  mobile  phone batteries,  its  rudimentary  disposal,  improper  collection  system  as  well  as  lack  of  cost-effective  processing technology  has  resulted  in  loss  of  valuables  encapsulated  in  it.  No  effective  technologies  exist  at  present within the country for safe recycling of electronic waste in the industry.  To address the aforesaid, CSIRNational  Metallurgical  Laboratory,  Jamshedpur  has  developed  a  process  for  ecological  recovery  of  cobalt and other valuable metals from the black powder and other constituents of LIBs. Further, laboratory has also developed  a  process  flow  sheet  to  recover  precious  metals  and  Co  &  Au  from  e-waste.  The  processes developed  have  been  transferred  to  industries  for  extraction  of  cobalt  metal/  salt  from  black  powder  of lithium batteries and recovery of precious metals from e-waste.

## Design & Development of Mob Control Vehicles

The  recent  statistics  from  Ministry  of  Home  Affairs  and  the  National  Crime  Records  Bureau  reveal  that substantial  numbers  of  riots/  communal  incidents  are  happening  every  year  in  India.  These  riots  are becoming very aggressive causing loss of human lives,  loss  of lives  of police/  security  personals,  loss  or public and private property etc. Due to easy availability of ammunitions, mobs are becoming more desperate and harmful to the society. With a view to provide security personal an advanced improved armoured vehicle to handle riots and mobs in the streets and urbanized areas, CSIR-CMERI has developed three Mob Control Vehicles (MCV). The first MCV is built on a tractor, fitted with hydraulically operated retractable shields and suitable  for  Police  and  BSF.  Other  significant  features  include  hydraulically  operated  stair;  IP  Bullet from view, rear view and side view cameras; PTZ Camera with 360-degree view mounted on a hydraulic operated platform with controller. The other developed MCVs are Heavy Category (Stallion chassis) MCV 7.5T  payload  and  Medium  Category  (LPTA  chassis)  MCV  2.5T  payload  with  add  on  features  like  Front shovel; Front shield; Water canon; Form spray system; Multi-Barrel Launchers (Mechanized shell loading); pressurised  cabin,  among  others  to  disperse  mob  surrounding  the  vehicle.  Mock  trials  and  Inspection  of Heavy  Category  (Stallion  chassis)  MCV  7.5T  payload  and  Tractor  based  MCVs  has  been  carried  out  by CRPF-RAF team. The results of the trial were satisfactory.

## Electronics Augmentation on Bullet Resistant Bunker (BRB) Vehicle

CSIR-CMERI electronically augment BRB vehicle of CRPF. The augmented features includes: Display with Wide  Coverage  to  achieve  a  Wide  FOV  (Field  of  view)    over  a  High  Range;    High  Speed  Video Transmission  to  Remote  Location  with  Dynamic  Cellular  Network  Assignment  via  Channel  Bonding  for High Speed Video Transmission; Public Addressing System (PAS) with Siren to help address the mob from vehicle; Search-cum-spot light  aids operations during night or low light scenarios: Range 100-150 m and GPS aided navigation & tracking system - allows the authorities to get the locational update of the vehicle with tracker accuracy upto  10m. The augmented vehicle was handed over to CRPF on July 18, 2019 in the presence of DG, CSIR and DG, CRPF. The vehicle was during Shri Amarnath Ji Yatra 2019.

## Vertical Slurry Transport System for Lifting of Minerals/Ores in Heterogeneous Regime

CSIR-IMMT has design,  developed  and  installed  a  vertical  lifting  system  for  hydraulic  transportation  of minerals/ores  has  been  successfully  completed.  The  pilot  test  set-up  consists  of  75mm  and  100  mm  hose pipes, a high pressure water pump, a rotary feeder of capacity in range of 8-10 Tons/hr., a mechanical pulsar mechanism for achieving pulsating flow with adequate instrumentation & data acquisition system. The test results indicated that, it is quite feasible to adopt the environment benign technology for vertical hoisting of minerals/ores  from  opencast  mines/sea  bed  mining,  with  anticipated  benefits  including  less  in-ground manpower,  less  maintenance,  potentially  lower  capital  and  running  costs.  The  technology  has  been demonstrated  to  M/s.  Dalmia  Cement  Ltd.,  Rajgangpur,  Odisha  for  possible  implementation  at  their limestone mines in Sundargarh District.

## Image-guided vascular vein visualizer (VeinViz)

In case of critical ill patients, intravenous (IV) therapy is considered as the fastest mean of providing fluids and medications through peripheral venous catheter. It is often a problem for clinicians to find and locate vein and in the process they pricks several time before placing the needle successfully, which causes pain and distress to the patient, and frustration to the clinicians. CSIR-CSIO is working to develop a non- invasive, real-time portable device for detection and visualization of peripheral subcutaneous veins of neonatal, obese and dark skin patients. A prototype of the device has been developed.

## Hydrogen Standard in Steel

Certified reference material (CRM) used for determination of hydrogen in steel by hot fusion technique is cumbersome in terms of both cost and time as it an import product to India. CSIR-NML has developed an indigenous  hydrogen  standard  (CRM)  in  steel  as  an  import  substitution.  The  CRM  developed  are  cost effective  (≈50%  reduced  cost)  compared  to  available  import  standard.  CSIR-NML  is  in  advance  stage  in commercializing the hydrogen standard in steel as an indigenous product for the Indian customers.

## CSIR-NCL Transfers Technology for Organic Farming

CSIR-National  Chemical  Laboratory  (CSIR-NCL),  Pune,  has  signed  a  Technology  Licensing  Agreement with Greenvention Biotech Pvt. Ltd, Pune, for integrated pest and pathogen management in agriculture using fungi  and  their  metabolites  ,  on  12th  June  2019.  Eco-Friendly,  integrated  pest  management  in  agriculture approach has been developed at CSIR-NCL as a technology using microorganisms such as fungi and their products. An eco-friendly, cost-effective, integrated pest management shall be useful to the farmers having small land holdings as well as to the farmers who export agricultural produce that has no chemical residues. Greenvention Biotech Pvt. Ltd is a start-up from Uruli-Kanchan (Pune) works on several agriculture-related products.

## Early Diagnosis of Prediabetes Using Novel Markers

According to the Global Report on Diabetes of World Health Organisation (WHO), an estimated 422 million people  were  living  with  diabetes  in  the  year  2014.  Prediabetes  will  affect  more  than  450  million  people worldwide by 2040. In the absence of prediabetes diagnoses all these people are at high risk of developing diabetes and microvascular complications. CSIR-NCL, Pune, in collaboration with the Chellaram Diabetes Institue,  Pune,  have  identified  some  novel  markers  for  efficient  prediction  of  prediabetes.  The  glycated peptides of a protein, namely Albumin were studied and differentiated to evaluate their ability to predict the prediabetic condition.  Prediabetes is a condition wherein the blood glucose or blood sugar levels in the body are higher than the normal. At a certain level of sugar in the body, it becomes type 2 diabetes which is the advanced stage. Prediabetes can be controlled with simple changes in lifestyle and eating habits. A study was carried out to quantify these four glycation sensitive peptides in the selected patients. All these peptides were observed with a higher fold difference in prediabetes than the corresponding unmodified peptides like FBG, PPG and HbA1c. The study suggested that these peptides may determine prediabetes more efficiently, and therefore they could form a potential panel of biomarkers for diagnosis of prediabetes.

## CSIR Technology Compendium

CSIR has come out with a technology compendium having technologies which are ready for commercialization. The compendium consists of 240 technologies which are at TRL 6 and above identified under  eight  themes.  The  copies  of  compendium  were  circulated  to  NITI  Aayog,  MoMSME,  and  other relevant Ministries/ Departments for wider publicity about the technologies of CSIR.

## Process for recovering iron, nickel and chromium from chromite overburden

CSIR-IMMT has developed a process for recovering iron, nickel and chromium from chromite overburden in the  form  of  nickel  and  chromium  bearing  pig  iron  has  been  developed.    A pilot scale campaign  has been successfully demonstrated for scaling up the process to 100 kg.The nickel bearing pig iron produced from Chromite overburden has been used for making stainless steel of HARDOX grade. The slag obtained during the smelting operation is further utilized for making value added products such as bricks, thereby making it a zero waste process.

The nickel bearing pig iron with nickel percentage ranging from 2- 18 % has been prepared by variation in smelting parameters. A metal yield of around 91 % is achieved for the nickel bearing pig iron containing 8 % nickel. The chromium bearing pig iron with chromium percentage ranging from 8-16 % has been prepared by variation in smelting parameters. An MoU has been signed with Jindal Stainless Ltd., Kalinganagar, Odisha for collaboration towards effective utilization of chromite overburden.

## Improved PNG (Piped Natural Gas) Burner

There are more than 50 lakh registered domestic PNG users in India. Due to unavailability of dedicated PNG burner  /  stove  customers  are  using  common  LPG  stoves  modified  for  PNG  which  is  unsafe  and  highly inefficient.  In  view  of  this,  CSIR-IIP  has  developed  a  domestic  cooking  burner  for  the  efficient  and  safe application  of  Piped  Natural  Gas  (PNG)  with  the  financial  support  of  PCRA,  New  Delhi.  The  developed PNG burner can save up to 25% of the precious fuel (PNG) ensuring the user safety at the same time.

## Technology for effective delivery of pheromones in fields

Pest  attack  results  in  a  loss  of  food  produce  worth  US$  470  billion  globally.  Pests  are  conventionally managed by spraying pesticides that could pollute soil and ground water. Pest control using sex pheromones is  a  revolutionary  technology  to  selectively  treat  pests,  without  the  use  of  pesticides  and  without  harming helpful insects. CSIR-NCL has developed technology for effective delivery of pheromones in fields.

## Drishti Systems at Runways of the Country - Niche Aerospace Technology implemented with IMD

Developed  and  manufactured  by  CSIR-National  Aerospace  Laboratories  (CSIR-NAL),  47  Systems  have been installed at 21 International Civilian Airports in the country.  Also, 54 Systems have been provided to 18 IAF Airbases. The market potential is about 180-200 numbers for both strategic and civil applications

## Salt Free Tanning Technology

Enabling the Indian leather industry for global competitiveness at reduced environmental impact, more than 10 million square feet of leather processed based on CSIR-Central Leather Research Institute (CSIR-CLRI) developed  technologies.    The  UNIDO,  Vienna  joined  hands  with  CSIR-CLRI  to  establish  UNIDO-CLRI Centre for Salt Free Tanning.

## Menthol Mint

India  is  global  leader  in  Menthol  Mint  production  due  to  CSIR  developed  plant  varieties  and  agrotechnologies: Area of menthol mint production increased from 50,000 hectares in 1994 to 2,50,000 hectares in  2015. The 80% of the area is under CSIR-CIMAP developed Kosi variety cultivation; Per unit area of production of menthol-rich menthe oil increased up to 50-60%.

## CSIR's  new  patented  Clot  buster,  PEGylated  Streptokinase  set  to  revolutionize  the  treatment  of Strokes

Ischemic stroke is a condition caused by a dysfunction in the supply of blood to the brain due to emboli, thrombus  or  atherosclerosis  occurring  in  cerebral  arteries.  Surprisingly,  the  prevalence  of  stroke  is  much higher in India than the West and about 87% of all strokes are ischemic strokes. CSIR-IMTECH and Epygen have entered into an agreement for the latter to develop PEGylated Streptokinase for treatment of Ischemic Stroke.

## Non-vascular self-expandable stents

Stents are used in the treatment of numerous biliary tract diseases, ranging from benign biliary diseases to malignant strictures. Two types of biliary stents find extensive use: plastic stents and self-expanding metallic stents.  Amongst  these  while  the  self-expandable  metal  stents  offer  longer  patency  their  prohibitive  cost makes them unaffordable.  CSIR-NCL in  collaboration  with  a  start-up  has  developed  a  new  class  of  selfexpandable stents based on a novel scroll design. These stents have been made with simple polymer-metal composites unlike the shape memory alloy based stents. These stents could be made a much lower costs than the currently available ones. Process for transferring the technology to two companies is on.

## CSIR's Divya Nayan for Visually Impound

CSIR-Central  Scientific  and  Industrial  Organization  has  developed  a  Personal  Reading  Machine  namedDivya Nayan, for Visually Impaired which can read any printed and digital books available in Hindi and English. Divya Nayan has been tested with a number of visually impaired people with different age groups and has gained wide popularity.

## Development and licensing of affordable Water Disinfection System Oneer TM

CSIR-Indian  Institute  of  Toxicology  Research  (CSIR-IITR),  Lucknow  has  developed  technology  for 'Drinking Water Disinfection System' with Trade name 'Oneer TM '. It is useful for continuous treatment of water.  The  technology  of  'Drinking  Water  Disinfection  System'  was  transferred  to  M/s  Bluebird  Water Purifiers, New Delhi. Oneer developed by CSIR-IITR will provide safe and clean drinking water at a cost of just 2 Paise / Ltr. The Community level model is of 450 LPH capacity. It can be scaled up to 5000 to 1 lakh L/day.

## Waterless Chrome Tanning Technology- a Game Changing Technology

Chromium is the most sought after tanning agent with about 2.0 billion sq. ft. of leather being made in India. About 20 thousand tons of chrome tanning agent is discharged in the wastewater. In order to overcome the problem, CSIR-CLRI has developed waterless chrome tanning technology. The waterless tanning technology has now found PAN INDIA acceptance, with tanners in all clusters enrolling for its adoption. The technology has been put to use in about 50 tanneries in the country. This is truly a game changing technology that has emerged from the CSIR through CLRI.

## Zero liquid discharge leather technology

A zero wastewater discharge process technology based on Electro-oxidation (EO) has been developed for the first  part  of  the  leather  manufacturing  process,  the  pre-tanning  processes.  The  potential  environmental benefits  and  potential  social  impacts  for  India  includes:  No  discharge  of  wastewater  from  tanneries;  The possible reduction of cost will be about Rs. 96 million per annum from reduction in the cost of wastewater treatment; This system does not result in generation of sludge (about 160 tons' sludge per annum) and less average annual fatalities due to release of H2S. The technology has been transferred to M/s Leayan Global Pvt ltd, Kanpur; M/s Royal Tanners, Kanpur; and AN Leathers Pvt Ltd, Agra.

## High Grade Gelatin from and Protein Hydrolysate from Raw Hide and Skin Trimming Wastes

Gelatin  is  widely  used  in  the  pharmaceutical  industry  to  make  capsules  for  drugs  as  well  as  in  the  food industry  to  make  jelly  candies,  ice  cream,  and  as  thickening  agent  in  cakes  and  soups.Leather  processing generates  huge  amount  of  raw  trimming  wastes.  CSIR-CLRI  has  developed  technology  for  making  high grade  gelatin  from  waste  material-trimmings  of  raw  hide.  The  technology  developed  by  CSIR-CLRI  is towards  complete  utilization  of  proteinous  constituents  present  in  the  trimmings.  This  technology  is exclusively licensed at a cost of Rs. One Crore to M/s Anipro Manufacturing Company for making gelatin and protein hydrolysate within India.

## Coal dust collecting and briquetting system

It  is  pertinent  to  collect  the  dust  from  mine  roads  and  put  it  to  alternative  use  not  only  for  reducing  air pollution  but  also  for  improving  the  health  of  local  populace.  Road  dust  collecting  system  has  been developed. CSIR-CIMFR has transferred the patented technology to M/s Tata Motors Limited, Mumbai.

## Phytopharmaceutical for Glucocorticoid-induced Osteoporosis

Globally glucocorticoid is the third biggest cause of osteoporosis. CSIR-CDRI has developed a standardized fraction of Cassia occidentalis Linn. for the treatment of glucocorticoid-induced osteoporosis and muscular atrophy.  Technology  licensed  to  M/s  Pharmanza  Herbals  Pvt  Ltd.,  Gujarat  for  further  development  and commerciazation as a Phytopharmaceutical drug. The product is under development in Phyto-pharmaceutical mode and would be available in Indian and the U.S. market after completing necessary studies as per the regulatory guidelines.

## Safe Disposal of Municipal Solid Waste utilising high temperature plasma

The technology has been developed for effective & eco-friendly disposal of municipal solid waste material generated  on  daily  basis  and  generation  of  fuel  gas  containing  predominantly  CO  and  H2  utilizating  high temperature (>3000 o C) Plasma arc. The technology has been licensed to M/s Positronics Innovation Pvt. Ltd, Kolkata, WB for commercialization on non-exclusive basis for a period of 5 years.

## Non-toxic Radiation Shielding Material for X-ray Protection

Non-toxic radiation shielding materials utilizing industrial waste like red mud (from aluminum industries) and  fly  ash  (Thermal  Power  Plants)  developed  which  has  been  accredited  by  Atomic  Energy  Regulatory Board (AERB) for application in diagnostic X-Ray rooms.

## JD Vaccine for Farm Animals

Vaccine developed and commercialized for Johne's disease affecting Sheep, Goat, Cow and Buffalo so as to immunize them and increase milk and meat production.

## PRABHASS Initiative of CSIR

On the directive of Hon'ble Prime Minister to engage the Global Indian S&T community through virtual platform, for addressing Indian societal challenges / problems, CSIR has developed (i) a database of over 200 well  acknowledged  Indian  S&T  diaspora  who  have  confirmed  to  participate  in  this  endeavour,  and  (ii)  a Virtual Platform - "PRABHASS" Pravasi Bharatiya Academic and Scientific Sampark (PRABHASS) Portal

aiming to serve as National Digital Platform to continuously engage with the Global Indian S&T Community for Societal Good. CSIR brought together all major central scientific ministries / departments  [DST, DBT, MoES, ICMR, ICAR, DRDO, DAE, DOS] and the Ministry of External Affairs, by setting up a Working Group for PRABHASS, with an objective to integrate similar  efforts of  different  departments  and  enable PRABHASS  serve  as  a  National  Digital  Platform  to  effectively  collaborate  with  Global  Indian  S&T Community for collectively promoting inclusive growth in India, strengthening Indian innovation ecosystem and contributing towards nation building".

## Indigenous Nano-Materials for Construction

CSIR-CBRI has developed cost effective nano-silica (n-SiO2) for high performance concrete to replace silica fume, an imported material. The prepared SNPs are amorphous, powdered, spherical and particle size ranges from  20-50  nm.  Pilot  Plant  for  preparation  of  SNPs  has  been  installed  and  running  successfully.  The developed nano-silica will result in speedy construction with higher performance and enhanced durability. It can be us as an admixture in cement/ concrete.

## Hybrid Agro Waste Composite Materials

CSIR  has  developed  a  process for manufacturing  agro  waste particulates/fibers (Parali) reinforced composites  as  an  alternative  for  Medium  density  fiberboard  (MDF).  The  process  has  been  developed  to utilize Parali (paddy straw) to provide a solution to avoid Parali burning.  Agro-waste based hybrid medium density composites materials can be used as a substitute for particle board for multifunctional applications in civil  infrastructure  as  door,  false  ceiling,  and  partition  and  furniture  materials.  The  developed  material  is durable and better in quality compared to MDF and particle board.

## Knowledge Partner of Uttar Pradesh State

CSIR is partnering with Uttar Pradesh to work as a Knowledge Partner to provide technology-based support for  development  in  the  areas  of  infrastructure,  water-source  protection,  agriculture,  health  protection, chemicals, petrochemicals, pharmaceuticals, defence technology etc in Uttar Pradesh. Pharma parks will also be developed in the UP state with the help of CSIR.

## Agarbattis from Flower Waste

CSIR has signed a MoU with Shri Mata Vaishno Devi Shrine Board at Katra to provide free consultancy, technical support and guidance to the Board for making Agarbattis from flower waste. Under the project, a small infrastructure facility will be created for making the incense sticks. The used flowers will be collected from the temples, petals segregated from stems, washed, dried, grinded and rolled to make the incense sticks.

## Large Scale Production of Graphene Oxide

Graphene oxide is extensively used in energy storage devices, polymer composites, desalination of water, conducting ink, aqueous lubrication, nano-coolant, additive for phase change materials, etc.  Graphene oxide is not toxic and hazardous for the environment. The cost of commercially available graphene oxide is very high and scaled-up production of graphene oxide at reasonable price without compromising the quality is a challenging task. The technology developed by CSIR demonstrates the production of graphene oxide starting from natural flake graphite.The Technology has been transferred to one Indian Industry for commercialization for a period of 5 years.

## Salivary Fluoride Detection Kit

The indigenous salivary fluoride level detection kit and sensor station is unprecedented in its kind towards diagnosis  of  salivary  fluoride  level  for  the  welfare  and  betterment  of  the  society.  It  protects  from  Dental Caries; helps in remineralization; protects against tooth decay; and helps prevent premature tooth loss. The Technology has been transferred to two Indian Industries for commercialization for a period of 5 years.

## Boring machine based on trenchless technology

Trenchless  construction  limits  the  amount  of  excavation  and  the  surface  repairs  needed  after  digging. Available imported machines are of large capacities for big projects and very expensive. No such machine is being manufactured indigenously. To address this gap, boring machine based on trenchless technology has been designed and developed.

The developed machine can bore upto 14 m length and 160 mm dia. holes under the roads and buildings for laying sewer/ pipe lines and cables. The developed machine is affordable and can be used by small/middle class contractors. It is light in weight, portable and requires low maintenance and Suitable for both wet and dry boring. The technology has been transferred to M/s Techno Industrial Marketing, Uttarakhand.

## Micro Fuel Cell

Micro fuel cell is a power source for electronic devices that converts chemical energy into electrical energy. The scaled down fuel cells can be used in electronic devices such as digital cameras, radios, toys and other low power applications. CSIR has developed cost effective, simple and easy to fabricate micro fuel cell for use in low power applications. Technology has been transferred to M/s Victor Industries Pvt. Ltd., Sangli, Maharashtra on non-exclusive basis.

## New Rice Variety with Low Glycemic Index Released- A Diabetic Friendly Rice

CSIR-CCMB in collaboration with the Indian Institute of Rice Research at Hyderabad has released a new variety of rice that resists pests and is also beneficial for those  with diabetes.  The new  Improved Samba Masuri (ISM) rice variety is resistant to Bacterial Blight (BB) and at the same time has the lowest Glycemic Index (GI) at 50.9 among all major rice varieties, which is an improvement over the 52.9 GI of the earlier Samba Masuri variety. At present, almost 40 per cent of the normal Samba Masuri rice crop is being lost due to Bacterial Blight (BB). The new ISM variety of rice is, therefore, expected to significantly reduce this crop loss,  which  eventually  would  lead  to  reduced  prices  of  rice  and  increased  profit  margins  for  farmers  and traders.  The  traditional  Samba  Masuri  rice  is  commonly  called  Sona  Masuri  and  Kurnool  Masuri  and  has very low resistance to BB, a pest disease for which there is no chemical solution yet.

## Handheld GPS-Enabled 'Ksheer Tester'-System for detection of Adulteration in milk

'Ksheer  Tester',  newly  developed  by  CSIR,  is  a  handheld  GPS-enabled  version  of  the  recently  launched Ksheer  Scanner  technology  to  check  adulteration  in  milk.  It will  empower  the  common  man  with  a technology to tackle a national level health hazard due to adulteration in milk. The device would enable any person to track the location of the tested sample and receive the test results through SMS on the device.

## CSIR's certification for coal used power plants

CSIR has signed an annual Rs. 250-crore deal with several state-run coal and thermal power companies to certify the quality of the coal being supplied and used in their facilities. The certification helps power plants

to use coal appropriate to the machinery and technology available in the plant and contribute to efficient use and,  in  the  long  run,  reduce  emissions.  It  provides  a  robust  mechanism  for  proper  inspection  of  coal  and overtime [and has led to an improvement in the quality of coal.

## Development of Green crackers with less pollutant emission

Ahead of Diwali, CSIR launched green firecrackers in a bid to "resolve the crisis of air pollution" in the capital. These environment friendly Crackers are of  new formulations for reduced emission light and sound emitting  crackers  with  30%  reduction  in  particulate  matter. CSIR  has  also  successfully  developed  various environment-friendly fireworks such as sound emitting crackers, flowerpots, pencils, chakkar and sparklers. CSIR  in  developing  these green  crackers  have  signed  nearly  230  MoUs  and  165  Non-disclosure Agreements with  firework  manufacturers  in  order  to  deliver  the  crackers.  Also  these  green  crackers  are equipped with a green logo as well as a Quick Response (QR) coding systems which have been developed for differentiation of green crackers from conventional crackers.

## 1000 Genome Sequencing completed

CSIR  has  conducted  Whole  Genome  Sequencing  of  1,008  Indians  from  different  populations  across  the country.  The  whole  genome  data  is    important  for  building  the  knowhow,  baseline  data  and  indigenous capacity  in  the  emerging  area  of  Precision  Medicine.    The  outcomes  of  this  will  have  applications  in  a number  of  areas  including  predictive  and  preventive  medicine  with  faster  and  efficient  diagnosis  of  rare genetic  diseases.  CSIR  also  pioneered  the  application  of  genomics  in  clinical  settings  in  the  area  of  rare genetic diseases in India by means of DNA/Genome based diagnostics and interaction with large number of clinical collaborators.

## CSIR's Integrated Skill Development initiative

CSIR labs established connect with various Sectoral Skill Councils (SSC):

-  Leather Sector Skill Council (CSIR-CLRI);
-  Life Sciences Sector Skill Council (CSIR-IICT);
-  Capital Goods Sector Skill Council (CSIR-CSIO);
-  Automotive Sector Skill (CSIR-CSIO);
-  Aerospace & Aviation Sector Skill Council (CSIR-NAL);
-  Agriculture Sector Skill Council (CSIR-NIO/ CSIR-NBRI/CSIR-IITR);
-  Skill Council for Mining Sector (CSIR-CIMFR); and
-  Health Care Skill Council (CSIR-IICB) and Paint & Coating Skill Council (CSIR-CECRI).

## CSIR  JIGYASA:    Inculcating  Scientific  Temper  in  Youth  Through  Vibrant  Scientists-Students Interaction

Under CSIR & KVS Student-Scientist connect programme 'JIGYASA'. 1151 Kendriya Vidyalayas connect with 37 CSIR Laboratories targeting one lakh students and nearly 1000 teachers annually. The focus is on connecting school students and scientists so as to extend student's classroom learning with that of a very well planned research laboratory based learning.

The programme is a unique platform to bringing in teachers and scientists for nurturing young minds. The programme envisages opening up the national scientific facilities to school children, enabling CSIR scientific knowledgebase and facility to be utilized by school children.

## CSIR Efforts for COVID Mitigation

The unprecedented situation arisen due to the COVID-19 pandemic has posed multifarious S&T challenges. CSIR has responded to the situation with a well-coordinated and integrated approach in cooperation with all relevant stakeholders. CSIR is extending all possible R&D support to the industry and is also aligned to the Government's strategy of mitigation of outbreak. Within the constraints of the lockdown in the country, the initiatives  undertaken  by  CSIR  so  far  can  be  broadly  categorized  under  the  five  verticals:  Digital  and Molecular Surveillance; Rapid and Economical Diagnosis; Development of new drugs/repurposing of drugs; Hospital Assistive Devices and PPEs; and Supply chain and logistics. CSIR has developed 100+ technologies under  these  technology  verticals  and  is  working  with  about  100  industries.  Some  of  the  technologies developed by CSIR are given below:

## Digital and Molecular Surveillance:

-  Coronavirus  genome  sequencing-  CSIR-CCMB,  CSIR-IGIB,  CSIR-IMTech,  CSIR-CDRI,  CSIRNBRI, CSIR-IITR are doing sequencing of coronavirus to know if any genetic changes are occurring in  the  virus  while  it  is  spreading  in  the  country.  The  information  will  help  gauge  the  severity  of disease in various geographical regions, developing an ELISA detection test, and ultimately vaccine against coronavirus.
-  Surveillance in Kolar, Karnataka; and Jamshedpur in collaboration with Tata Group
-  Sero-Surveillance-  CSIR  Cohort-Scientists  and  staff  of  all  CSIR  laboratories  are  being  tested  for presence of corona antibody following due ethical procedure.
-  Sewage  Surveillance-CSIR-CCMB  has  developed  this  procedure  and  tested  in  Hyderabad.  CSIRCCMB and CSIR-NEERI will undertake such studies in other cities.
-  Testing Capacity: Thirteen (13) CSIR labs are engaged in corona testing. Lab wise tests done so far as on January 15, 2021 are given below:
-  CSIR-CFTRI  and  CSIR-IHBT  provided  nutritional  food  packets  to  needy  in  several  parts  of  the country.

| Name of Laboratories   | Total tests done   |
|------------------------|--------------------|
| CSIR-IIIM              | 60,562             |
| CSIR-IMTech            | 8,821              |
| CSIR-IHBT              | 82,586             |
| CSIR-NEERI             | 31,179             |
| CSIR-IITR              | 1,82,620           |
| CSIR-CCMB              | 55,617             |
| CSIR-CDRI              | 1,00,955           |
| CSIR-CLRI              | 21,357             |
| CSIR-IGIB              | 15,297             |
| CSIR-NEIST             | 37,442             |
| CSIR-IIP               | 7,935              |
| CSIR-NBRI              | 1,06,581           |
| CSIR-CFTRI             | 1,07,173           |

## Diagnostics:

-  FELUDA  (FNCAS9  Editor-Linked  Uniform  Detection  Assay)  -  A  Novel,  Rapid,  Simple, Affordable and Innovative COVID-19 Diagnostic: A CRISPR/ Cas-9 -based paper diagnostic test has  been  developed  by  CSIR.  The  FELUDA  methodology  has  been  developed  in  CSIR-IGIB  for detecting single nucleotide variants in RNA or DNA or more broadly detecting any DNA or RNA fragment, without the need for sequencing. This makes it only the third nation in the world to use this technology for Covid-19 diagnosis. The CSIR technology, which has been licensed to TATA Sons, has received DCGI approval and is now being manufactured and marketed as TataMD CHECK. It is the world's first CRISPR Cas-9 based diagnostic tool to be launched globally and will be available through diagnostic centers and hospitals across India.
-  Loop-mediated  isothermal  amplification (LAMP)-PCR: LAMP  is  an  isothermal  nucleic  acid amplification technique. In contrast to the polymerase chain reaction (PCR) technology, in which the reaction is carried out with a series of alternating temperature steps or cycles, isothermal amplification  is  carried  out  at  a  constant  temperature,  and  does  not  require  a thermal  cycler.  The technology has been transferred to Reliance Industries. Currently, it is under validation at ICMR.
-  Dry Swab Technology for RT-PCR: CSIR-CCMB has developed RNA extraction free dry swab method for RTPCR based detection of SARS-CoV-2.  The method will save time and reduce cost as compared to standard PCR test using Viral Transport Medium (VTM) and RNA extraction. ICMR has conducted two validations of the dry swab method in August and November 2020 respectively. Results indicated that the sensitivity of the dry swab variant method is 79% and specificity is 99% when compared with standard RTPCR test as the gold standard. Considering its lesser cost and quick turn-around,  the  dry  swab  variant  method  can  be  used  as  a  screening  tool  only  in  settings  where automated RNA extraction is not available.
-  Large scale sample testing using NGS: Next-generation sequencing (NGS) allows for analyzing a large number of viral sequences from infected patients, presenting novel prospects for studying the structure  of  viral  populations,  and  understanding  virus  evolution  and  epidemiology.  CSIR  and Syngene have come together to use NGS for testing of a large number of samples. Using sample pooling and barcoding, it is possible to do sample testing of about 20,000 samples within 2 days. The technology has been submitted to ICMR for approval.
-  Antibody detection in Blood: For  identification  and  quantification  of  total  Ab  specific  to  SARSCoV-2,  a  kit  has  been  developed  on  a  FortBio  Octet  Platform  [Bio-Layer  Interferometry].  The developed test is Fast (<1 minute/sample), low cost (₹ 50/test, 200 tests/hr), Error-free @ picomole level, Direct blood (20ml) process, 2000 tests/day/unit/person.
-  Implementing  Micro  and  Mega-Lab  sequencing-based  SARS-CoV2  diagnostics  for  cost  and time effective molecular epidemiology

A first of its kind genome sequencing laboratory is has been launched at the New Delhi International Airport for testing samples of all travelers arriving into the country who test positive for Coronavirus disease (Covid-19). The positive samples will be genome sequenced to identify and contain the new mutant variant of Sars-CoV-2, the virus that causes Covid-19, detected in the UK and other countries. Spice  Health  and  CSIR-IGIB  have  agreed  with  doing  Nanopore-based  sequencing.  The  study involves NCDC and has been started as a pilot project at Delhi airport.

## Drugs Development:

CSIR has deep knowledgebase for developing generic drugs and is also known for the development of many new drugs. Indian Generic drugs Industry which supplies drugs to about 200 countries is in strong position because of synthetic processes developed by CSIR-IICT, CSIR-NCL, CSIR-CDRI and CSIR-IIIM. In order to utilize its knowledgebase and help India people fight the menace of coronavirus, CSIR has identified some drugs for synthesis and repurposing which are given below.

-  Favipiravir: CSIR has developed and patented the synthesis of Favipiravir. In India, initially Favipiravir was launched by GlenMark as oral formulation for treatment of corona at Rs 102 per  tablet  of  200  mg  dosage.  Within  6  weeks,  CSIR-IICT  process  became  commercial  with  Cipla which  launched  it  at  Rs  68  per  tablet.  In  the  meantime,  CSIR-IICT  has  transferred  the  process  to another 5 companies on non-exclusive basis. All this competition resulted in further reduction in the drug price to Rs 40 per tablet.  This product is approved by DCGI as drug for mild and moderate patients of Covid-19.
-  Remdesivir: CSIR-IICT  has  developed  the  process  for  Remdesivir.  CSIR-IICT  developed  the process even before the tech pack by the innovator Gilead was given to 6 major pharma companies in India. Because of ready know-how, now more than 6 companies compete in the market and the price initially  was  Rs  5800  per  injection  of  100  mg  which  came  down  to  around  Rs.  2800  per injection. CSIR-IICT know-how helped start-ups and CROs to supply key intermediates to the major pharma companies in minimizing import of key starting materials.
-  Arbidol: CSIR-CDRI  has  developed  process  technology  and  undertaking  clinical  trials  with  a company.
-  Phytopharmaceutical Formulation: CSIR and Sun Pharma are developing ACQH, a  formulation developed  for  dengue  being  repositioned  for  coronavirus.  The  application  for  the  clinical  trial  has been  submitted  to  DCGI  and  approval  is  expected  soon.  This  is  first  phyto-pharmaceuticals application from the country.
-  Ayush Drugs: CSIR-IIIM, Jammu is conducting clinical trials of the following Ayush formulations:
-  Withania somnifera ( Ashwagandha)
-  Tinospora cordifolia (Guduchi)
-  Glycyrrhiza glabra (Mulethi)

## Hospital Assistive Devices:

-  Swasthavayu  -  An  Indigenous  Non-invasive  BiPAP  Ventilator: To  address  the  shortage  of ventilators  faced  during  the  Covid-19  pandemic,  CSIR-NAL  has  developed  the  non-invasive ventilator  called  Swasthvayu  in  a  record  time  of  36  days.  This  ventilator  can  be  used  in  non-ICU settings  such  as  make  shift  hospitals  etc.  for  addressing  respiratory  problems  in  mild  Covid-19 patients.    The  ventilator  has  undergone  several  regulatory  certifications  and  also  clinical  trials  on patients  at  multiple  hospitals  and  has  received  approval  from  DGHS  and  the  technology  has  been transferred to multiple industries.
-  Coverall: CSIR-NAL  has  developed  high  quality  PPEs  and  transferred  the  technology  to  MAFL, Bengaluru. After certification, about one lakh pieces have been supplied to Government. The current

capacity  of  the  production  is  7000/day  which  can  be  enhanced  to  30,000/day  depending  upon requirement.

##  Face Mask: CSIR constituent's laboratories have developed following face masks:

- o High  Efficiency  Hydrophobic  Three-Layered  Facemask: The  facemask  is  composed  of two/three hydrophobic non-woven polypropylene (PP) layers in the outer and inner side and a 'High Efficiency Particulate Air' filter in the middle.  The performance of the developed mask certified from SITRA, Coimbatore.
- o Poly  Ti:A  Biopolymer  Coated  Medical  Grade  Mask: It  is  a  two  layered  masks  that  use biopolymer (Bacterial cellulose) coated mask, which are having much higher surface area and very fine nanofiber of cellulose to trap viruses and bacteria. It is developed using the patented technology of CSIR-NCL on Bacterial cellulose.   The performance of the developed mask certified from SITRA, Coimbatore.
- o Reusable Face Mask with Antimicrobial Coating: It is a tri-layered mask which consists of the hydrophobic outer layer that repels the liquid aerosol and the middle bactericidal layer to kill  the  microbes  that  comes  in  contact  with  the  masks  thereby  providing  dual  protection benefits to the end-users. The inner hydrophilic layer absorbs the hot air, sweat and facilitates improved breathability. These masks and the coatings have been designed and formulated to sustain  up  to  30-50  washes.  The  properties  of  the  masks  have  been  certified  by  SITRA, Coimbatore.

Makeshift Hospital: CSIR-CBRI and CSIR-SERC have developed the technology of fabricating makeshift hospital within a short span of time. L&T is the industrial partner for this activity. Demonstration hospitals (consisting of 10 bed) has been erected at Ghaziabad and 4 th Bn National Disaster Response Force (NDRF), Arakkonam.

## Annexure-II

## Fast Track Translation (FTT)/ Fast Track Commercialization (FTC) Projects implemented during FY 2018-2020

|   Sr. No. | CSIR Lab   | Project Title                                                                                                                                              |
|-----------|------------|------------------------------------------------------------------------------------------------------------------------------------------------------------|
|         1 | CSIR-AMPRI | Red mud based lead free material for X-ray and CT scanner rooms                                                                                            |
|         2 | CSIR-AMPRI | Development of multilayer sandwich panel for defense applications                                                                                          |
|         3 | CSIR-AMPRI | Development of Fly Ash based Geopolymeric Materials for Broad Application Spectrum                                                                         |
|         4 | CSIR-AMPRI | Pilot scale production and demonstration of closed cell aluminum composite and hybrid composite foams for transportation, defence and construction sectors |
|         5 | CSIR-AMPRI | Advanced Geopolymeric Coating Material for Structures of Mild Steel (AGCM)                                                                                 |
|         6 | CSIR-AMPRI | Development and Manufacturing hybrid green composites using industrial and agro wastes in pilot scale and facilitating entrepreneurship                    |
|         7 | CSIR-AMPRI | Development of solid-state electromagnetic joining technique for materials of interest in aerospace/space                                                  |
|         8 | CSIR-AMPRI | Design & Development of bamboo structures (Bamboo/composite sections &joints)                                                                              |
|         9 | CSIR-CECRI | A surface treatment process for enhanced corrosion resistance of Iron and steel                                                                            |
|        10 | CSIR-CECRI | SX-EW process for the regeneration of etchant and recovery of copper from spent alkaline ammoniacal cupric chloride PCB etchant                            |
|        11 | CSIR-CECRI | Multi-analyte sensing platforms and molecular probes for detection of target biomarkers using electrochemical and optical methods                          |
|        12 | CSIR-CECRI | Thermal barrier coatings for strategic applications                                                                                                        |
|        13 | CSIR-CECRI | Self-humidified Nafion based composite membranes for open cathode PEMFC stacks                                                                             |
|        14 | CSIR-CECRI | Development of 2.5V / 1A sodium-ion batteries with performance scalability possibilities                                                                   |
|        15 | CSIR-CECRI | Development and demonstration of rechargeable Li-S batteries for lighting and consumer electronics applications                                            |
|        16 | CSIR-CGCRI | 100 W CW/Modulated Thulium fiber laser: at 1.94 µm for efficient tissue vaporization and at 2.05 µm for strategic application                              |
|        17 | CSIR-CGCRI | Wear resistant Ceramics for cutting & milling operation: Process optimization of SiAlON-WC composites for rock drilling application                        |

|   18. |             | Synthetic high alumina aggregate from sillimanite beach sand for refractory application                                                                                                                                                                                                   |
|-------|-------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    19 |             | Superior fused magnesia from impure Indian magnesite for self sustenance                                                                                                                                                                                                                  |
|    20 | CSIR-CMERI  | Process technology for large area (10 cmX10 cm) manufacturing of micro-nano patterned (300 nm-300 micron) hydrophobic surfaces                                                                                                                                                            |
|    21 | CSIR-CMERI  | An engineered design and development of a solar assisted community level multifunctional adsorbent based integrated water filtration unit for removal of ground water fluoride, microorganism with supported handy fluoride level detection kit and proper management of generated sludge |
|    22 | CSIR-CMERI  | Design and Development of 1 TPD Fully Automatic Biodiesel Plant                                                                                                                                                                                                                           |
|    23 | CSIR-CMERI  | Design and development of Mob Control Vehicle (MCV)                                                                                                                                                                                                                                       |
|    24 | CSIR-CMERI  | Development of Carbon-Graphite Piston Ring and Solenoid Valve suitable for high temperature aircraft LRUs                                                                                                                                                                                 |
|    25 | CSIR-CMERI  | Development of self-propelled specialty harvester for leafy crops with a minimum field capacity of 4 acre/day (ex. Stevia, mentha, vegetables)                                                                                                                                            |
|    26 | CSIR-CMERI  | Design of a combined cutting, binding and bailing equipment for stubble management                                                                                                                                                                                                        |
|    27 | CSIR-CCMB   | Develop novel DNA based identification system of Plant bioresources (both agri and wild varieties grown/harvested) for conservation                                                                                                                                                       |
|    28 | CSIR-CCMB   | Development of male infertility diagnostic kits (DeMID)                                                                                                                                                                                                                                   |
|    29 | CSIR-CCMB   | Up scaling of high yielding / elite Samba Mahsuri mutant line 'SM93' for product translation                                                                                                                                                                                              |
|    30 | CSIR-CCMB   | Development of climate resilient lines of the bacterial blight resistant and low glycemic index rice variety, Improved Samba Mahsuri possessing resistance against blast disease and enhanced tolerance to submergence and drought                                                        |
|    31 | CSIR-CBRI   | Pilot Scale Preparation of Silica Nanoparticles and their applications in cement based materials                                                                                                                                                                                          |
|    32 | CSIR-CDRI   | Clinical development of antiplatelet compound S007-867 for treatment of cardiovascular diseases. (Antithrombo-867)                                                                                                                                                                        |
|    33 | CSIR-CDRI   | Development of a small molecule inhibitor of PCSK 9                                                                                                                                                                                                                                       |
|    34 | CSIR-CEERI  | Design and Development of Dispenser Cathodes for Microwave Tubes                                                                                                                                                                                                                          |
|    35 | CSIR-CEERI  | Development and optimization of software for real-time monitoring of milk supply chain                                                                                                                                                                                                    |
|    36 | CSIR-CEERI  | Solar PV based Smart Multi-vehicle EV Charging Station                                                                                                                                                                                                                                    |
|    37 | CSIR-CSMCRI | Energy efficient process to treat the reject stream of water desalination                                                                                                                                                                                                                 |

|    |            | plant                                                                                                                                 |
|----|------------|---------------------------------------------------------------------------------------------------------------------------------------|
| 38 |            | Generation of energy from microalgal feedstock through CO 2 capture from flue gases                                                   |
| 39 |            | Greener process for the synthesis of 3-methyl-5-phenylpentanol (Mefrosol) at 1 Kg level with >90% yield ad 98% purity                 |
| 40 | CSIR-CSIO  | Smart Electrochemical Tongue (e-Tongue) to detect heavy metal ions in potable water                                                   |
| 41 | CSIR-CSIO  | Image Guided vascular vein visualizer: VeinViz                                                                                        |
| 42 | CSIR-CSIO  | Electromyogram (EMG) controlled Below Elbow prosthesis                                                                                |
| 43 | CSIR-CSIO  | Technological solutions for contactless alive/dead detection of victim soldier in battle field                                        |
| 44 | CSIR-CSIO  | Precision instrumentation towards whole-slide digital microscopy for high-throughput analytics                                        |
| 45 | CSIR-CSIO  | Ligament Injury Assessment & Therapy Device for motor- rehabilitation of Soldiers 'L-GEAR'                                            |
| 46 | CSIR-CSIO  | Online Monitoring System for detection of Night-time Poor Visibility areas in Urban settings                                          |
| 47 | CSIR-CSIO  | Harvesting of electrical energy using geared AC synchronous motor to charge batteries of mobile phones                                |
| 48 | CSIR-CSIO  | Design and Development of Airfield Ground Lighting Systems (AGLS)                                                                     |
| 49 | CSIR-CSIO  | Design and development of enhanced vision system for military surface transport vehicles                                              |
| 50 | CSIR-CSIO  | Design &Development of Head Up Display for Passenger Aircraft                                                                         |
| 51 | CSIR-CSIO  | Divya Nayan: A personal reading machine for visually impaired                                                                         |
| 52 | CSIR-CSIO  | Scale - Up of AutoCEPH: A software for 2D computerized Cephalometirc Analysis as a web service                                        |
| 53 | CSIR-CSIO  | Design and Development of Indigenized Lyophiliser for preservation of Indian fruits and vegetables                                    |
| 54 |            | Bio-methanation of coal rejects / low grade coal and biomass- Demonstration Model at village Gaurigram, Chandankiyari, Dhanbad        |
| 55 | CSIR-CIMFR | Installation and commissioning of a 10000 LPH coalmine water reclamation plant for obtaining drinking water                           |
| 56 | CSIR-CLRI  | Retanning cum fatliquoring agent                                                                                                      |
| 57 | CSIR-CLRI  | Retanning agent from Paper Industry Wastes                                                                                            |
| 58 | CSIR-CLRI  | Waterless Chrome Tanning Technology                                                                                                   |
| 59 | CSIR-IICT  | Development of Engineered Biochar from non-edible de-oiled seed cake/stubble wastes for the removal of targeted herbicides/pesticides |

|    | from agricultural wastewaters and subsequent soil remediation                                                                                                                                                    |
|----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 60 | Catalytic conversion of linear alkylbenzene raffinate to be utilized for Jet rocket fuel                                                                                                                         |
| 61 | Indigenous enzymes for degumming of rice bran oil and other vegetable oils                                                                                                                                       |
| 62 | Preparation of polymer-grade vinylidenefluoride (VDF) and chlorotrifluoroethylene (CTFE) and their polymerization processes                                                                                      |
| 63 | In-house development and fabrication of stirred mills for energy- efficient processing of low-grade ores                                                                                                         |
| 64 | Synthesis of Mg-Y 2 O 3 magnesium nano-composite by hot consolidation process for light weight applications                                                                                                      |
| 65 | Production of Sm 2 O 3 and CO 3 O 4 from SmCo permanent magnet scrap                                                                                                                                             |
| 66 | Design & development of a vertical slurry transport system for lifting of minerals/ores in heterogeneous regime                                                                                                  |
| 67 | Recovery of Nickel, Chromium and Iron from Chromite Overburden (COB) in 100 kg scale                                                                                                                             |
| 68 | Membrane technology for separation/recovery of heavy metals (Cr, Ni, Zn) from industrial waste water: Mathematical modeling and process development                                                              |
| 69 | Development of advanced Tribological Coatings and Environmental Barrier Coatings (EBC) by Electrophoretic deposition and thermal spraying for mining equipments, pipeline, industrial applications and processes |
| 70 | Development of Novel Tungsten Alloy Cubes for Strategic Applications                                                                                                                                             |
| 71 | Wireless Thermocouple for temperature measurement of rotating and moving surfaces                                                                                                                                |
| 72 | Development of cost effective Industry grade non contact type online moisture sensor using microwave and NIR                                                                                                     |
| 73 | Development of an Image Processing based system for monitoring feed rate of materials moving on a conveyor                                                                                                       |
| 74 | Development of an induration furnace monitoring system with IoT and Artificial Intelligence (AI) technique in a pelletization plant                                                                              |
| 75 | Processing of secondary resources for the production of battery materials                                                                                                                                        |
| 76 | Rapid and Point Care Microfluidic kit for multiplex diagnosis of viral diseases in tomato and apple                                                                                                              |
| 77 | Development of bacterial formulations and organic dustbin for organic waste degradation in cold hilly regions                                                                                                    |
| 78 | Optimization of aeroponic and hydroponic conditions for increasing                                                                                                                                               |

|     |             | commercial crop productivity                                                                                                                  |
|-----|-------------|-----------------------------------------------------------------------------------------------------------------------------------------------|
|  79 |             | Introduction of high value spice Saffron (Crocus sativus L.) in unexplored areas                                                              |
|  80 |             | Identification of improved clone(s) of Stevia rebaudiana (Bertoni)                                                                            |
|  81 |             | Combating Iron and Zinc deficiency using microalgae based foods                                                                               |
|  82 |             | L-Asparaginase (HimAspaseTM) with no glutaminase activity for food processing and therapeutic applications                                    |
|  83 | CSIR-IGIB   | Genomic Approaches for Rare Genetic Disease Diagnosis (RareGen)                                                                               |
|  84 | CSIR-IGIB   | Radiological AI system for Parallel Informatic Detection of Clinical Triage emergencies (RAPID-CT)                                            |
|  85 | CSIR-IGIB   | GOMED-TeCh: Development, Translation and Commercialization of Genetic tests for prevalent genetic diseases in India                           |
|  86 | CSIR-IGIB   | Genomics for Public Health in India (IndiGen)                                                                                                 |
|  87 | CSIR-IMTECH | Development of bio-better of G-CSF (Granulocyte-Colony Stimulating Factor) for prophylactic and therapeutic interventions in neutropenia      |
|  88 | CSIR-IMTECH | Validation of potential biomolecules against Parkinson's disease: A pre-clinical study                                                        |
|  89 | CSIR-IMTECH | Development of Anti Thrombin-Clot Specific Streptokinase (ACSSK), for Treatment of Acute Myocardial Infarction and Ischemic Stroke            |
|  90 | CSIR-IMTECH | Technology development for Gellan gum production                                                                                              |
|  91 | CSIR-IMTECH | Development of applications of laccase for Diverse (Food health and cosmetic) Industries (DALDI)                                              |
|  92 | CSIR-IIP    | Aircraft testing with Bio-Aviation fuel blended in Jet-A1 fuel                                                                                |
|  93 | CSIR-IIP    | Development of Catalyst and Alternate Process for Producing Light Olefins (C2-C4)                                                             |
|  94 | CSIR-NEIST  | Efficient and large scale production of carbon quantum dots (CQDTs) from cheap coal feedstock                                                 |
|  95 | CSIR-NIIST  | Development of an onsite sewage treatment for small establishments                                                                            |
|  96 | CSIR-NIIST  | Development of Cellular Sensors: Biocompatible fluorescent molecules for sensing and cellular imaging of PH, Zn2+ and reactive oxygen species |
|  97 | CSIR-NIIST  | Fused Thiophene based FET devices for lung cancer VOC biomarker detection                                                                     |
|  98 | CSIR-NIIST  | Electrochromic Devices for Efficient Energy Management and Utilization                                                                        |
|  99 | CSIR-NIIST  | Development of lithium silicate based ceramics as CO2 sorbents for sorption enhanced steam methane reforming                                  |
| 100 | CSIR-NIIST  | Technology assessment and integration of CSIR's lignocellulosic ethanol programs/facilitating technologies for a feasible 2G ethanol          |

|     |            | technology (CSIR-2GE)                                                                                                                                               |
|-----|------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 101 |            | Fluorescent Materials for Security Applications                                                                                                                     |
| 102 | CSIR-NML   | Annealing simulator integrated with online process control sensors for run out table process simulation                                                             |
| 103 | CSIR-NML   | Piloting of the process for Production of Premium Grade Iron Oxide from Waste Ferrous Chloride Solution Generated from Steel Pickling and Ilmenite Processing Units |
| 104 | CSIR-NML   | Pilot scale processes for recycling of metals/ materials from E-waste                                                                                               |
| 105 | CSIR-NML   | Development of biodegradable eco-friendly flotation reagents for sillimanite, limestone, iron ore fines and coal                                                    |
| 106 | CSIR-NML   | Smart sensing system for cold drawn high end wires                                                                                                                  |
| 107 | CSIR-NML   | Scale up and commercialization of indigenously developed hydrogen standard in steel                                                                                 |
| 108 | CSIR-NBRI  | Bio-prospecting plant diversity for food grade colors                                                                                                               |
| 109 | CSIR-NEERI | Restoration of Nallah with Ecological Units - RENEU                                                                                                                 |
| 110 | CSIR-NEERI | Development, Demonstration and Dissemination of Improved Ceramic based Cook-stoves (Both domestic and Community) for Particulate Emissions Control                  |
| 111 | CSIR-NEERI | RISK-PiNET : GIS based Risk Assessment Modelling Tool for Water Distribution System                                                                                 |
| 112 | CSIR-NEERI | Smart Disposal, Incineration and Carbonization Systems (SMART- DISC) for Menstrual Waste Management                                                                 |
| 113 | CSIR-NEERI | Utilization of industrial waste through appropriate technologies for developing value-added Products                                                                |
| 114 | CSIR-NEERI | Scale-up of process for CO 2 capture based on biogenic molecules and pilot scale demonstrations                                                                     |
| 115 | CSIR-NAL   | Stealth Technologies: Development of Radar Absorbing Materials/ Coatings for Airborne Platforms                                                                     |
| 116 | CSIR-NAL   | VTOL Winged UAV for multi-mission application (VTOL-UAV)                                                                                                            |
| 117 | CSIR-NCL   | Energy efficient clean production of hydrogen                                                                                                                       |
| 118 | CSIR-NCL   | Smart AGroinformatics with Internet of Things to enable Agriculture- 4.0 (SAGITA)                                                                                   |
| 119 | CSIR-NCL   | Continuous manufacturing platform for diazonium salt based reactions for synthesis of Azo dyes and APIs                                                             |
| 120 | CSIR-NIO   | Coral Reef Monitoring and Surveillance Robot (C-Bot)                                                                                                                |

## Ongoing Fast Track Translation (FTT)/ Fast Track Commercialization (FTC) Projects (Financial Year 2020-2022)

|   1. | CSIR-AMPRI              | Lightweight Aluminium hybrid foam core multi-layer sandwich panels with metal / 3D Carbon Fibre / Kevlar as face sheets for aerospace, blast resistance and transportation applications   |
|------|-------------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    2 | CSIR-CECRI              | Aerogel based thermal protection systems for nozzle surfaces in space and aerospace applications                                                                                          |
|    3 | CSIR-CECRI              | Development of eco-friendly trivalent chromium plating process                                                                                                                            |
|    4 | CSIR-CEERI              | Development of High Power Thyratrons for Fast Switching Applications                                                                                                                      |
|    5 | CSIR-CEERI+ IIIM+ CFTRI | Development of rapid Honey adulteration detection system                                                                                                                                  |
|    6 | CSIR-CSIO               | Batch digital microscopy with marker-specific auto-scoring for high- throughput analytics                                                                                                 |
|    7 | CSIR-CSIO               | Development of force-distance curve based Atomic Force Microscope for multi-parametric Imaging of Biological Systems.                                                                     |
|    8 | CSIR-CSIO               | Energy Management using Non-Intrusive Load Monitoring (NILM) Technique                                                                                                                    |
|    9 | CSIR-CSIO               | Marine Bearing Sight for Indian Naval Ships and Submarines                                                                                                                                |
|   10 | CSIR-CSIO               | Postural Stability Assessment System (Dynamic)                                                                                                                                            |
|   11 | CSIR-CSIO               | Visual Landing Aids for Naval Operations                                                                                                                                                  |
|   12 | CSIR-IMMT + NAL         | Stealth Technologies: Development of carbon- Ferrite composites materials for microwave absorbing                                                                                         |
|   13 | CSIR-NAL                | Development of spin valve GMRbased current sensor                                                                                                                                         |
|   14 | CSIR-NPL                | Broadband Rydberg Atom-based Quantum Sensor                                                                                                                                               |
|   15 | CSIR-CBRI               | Development of technology for high strength binder/value added building products using flue gas desulphurization (FGD) gypsum - a by-product of coal based thermal power plants           |
|   16 | CSIR-CBRI               | Technology package for eco-friendly burnt clay bricks with low carbon footprints                                                                                                          |
|   17 | CSIR-CBRI               | Valorization of lime sludge through development of environmental friendly building products                                                                                               |
|   18 | CSIR-CBRI               | Utilization of marble waste to develop cost-effective sustainable building products                                                                                                       |
|   19 | CSIR-CMERI              | Batch scale production of high quality activated carbon from biomass wastes for waste water treatment - an initiative towards waste to wealth                                             |

|   20. | CSIR-CMERI   | Design & development of self-sustainable integrated municipal solid waste disposal system (iMSWDS) for bulk waste generator                                        |
|-------|--------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    21 | CSIR-CRRI    | Microscopic traffic network simulation model for mixed traffic conditions (MiTraNS)                                                                                |
|    22 | CSIR-SERC    | Development of simple low cost flexible heating module for assessing fire rating of steel structural components                                                    |
|    23 | CSIR-SERC    | Dissipative fuse link beam-column connection for seismic resilient steel moment frames                                                                             |
|    24 | CSIR-SERC    | Folded textile reinforced concrete fencing panels for highway and other infra project applications                                                                 |
|    25 | CSIR-AMPRI   | Development of Advanced Non - Toxic Radiation Shielding Material From Tailored Brine Sludge                                                                        |
|    26 | CSIR-AMPRI   | Light Weight Aluminium Alloy Matrix composites for automobile, defence and Engineering Applications                                                                |
|    27 | CSIR-CECRI   | Indigenous Development of Phosphors for Image Intensifier Tubes                                                                                                    |
|    28 | CSIR-CECRI   | Super Hard Nanocomposite Coatings by PVD onto Automotive Chain Pins/Cutting Tools                                                                                  |
|    29 | CSIR-CGCRI   | Development of high-power optical amplifier (1.0 -5.0 W)                                                                                                           |
|    30 | CSIR-CGCRI   | High piezoelectric coefficient composites for application as flank array sensors                                                                                   |
|    31 | CSIR-IMMT    | Development of process for reduction roasting of low and lean grade iron ores using fluidized bed roaster (in pilot scale) to maximize the recovery of iron values |
|    32 | CSIR-IMMT    | Pilot Scale Study of Reduction of Phosphorous Content in High Phosphorus Indian Iron Ore                                                                           |
|    33 | CSIR-IMMT    | Processing of spent liquor for improvement of alumina productivity in Bayer process                                                                                |
|    34 | CSIR-IMMT    | Development and scale up studies for Cu incorporated Zn/Al layered double hydroxide antimicrobial material as protective cement additive                           |
|    35 | CSIR-NML     | Development of advanced giant magneto-impedance (GMI) based sensor for structural health monitoring of engineering structure with enhanced area coverage           |
|    36 | CSIR-NML     | Production of Fe-Ni/Co-Mo metallic alloy & alumina rich slag from NiMo/Co-Mo spent catalysts                                                                       |
|    37 | CSIR-NML     | Pilot plant and commercial plant scale flotation studies using newly                                                                                               |

|    |             | developed eco-friendly reagents for limestone and sillimanite flotation                                                                           |
|----|-------------|---------------------------------------------------------------------------------------------------------------------------------------------------|
| 38 | CSIR-NML    | Development of CS Analytical and Charpy Impact Toughness Physical Standard (CRM) in Steel                                                         |
| 39 | CSIR-NML    | Development of the close loop pilot process for recycling of metals/ materials from e-waste                                                       |
| 40 | CSIR-NML    | Industrial Hot Rolling Run Out Table and Continuous Annealing Line Simulations for developing Advanced High Strength Steels (AHSS)                |
| 41 | CSIR-CECRI  | Design and development of electrodes to generate hydrogen peroxide                                                                                |
| 42 | CSIR-CLRI   | Translation of Technology on Preservation-cum-Unhairing of Hides and Skins                                                                        |
| 43 | CSIR-CLRI   | Translation of the Technology on 'Manufacturing Organic Supplement and Compost from Hair Waste"                                                   |
| 44 | CSIR-CSMCRI | Greener process for the synthesis of perfumery chemicals alpha- Campholenic aldehyde and Carveol at 1 Kg level in ~85% yield and >95% purity      |
| 45 | CSIR-CSMCRI | Deployment of Integrated process for enhancement of brine evaporation rate @ 30-40% to improve yield of solar salt in existing areas              |
| 46 | CSIR-CSMCRI | Multi-locational Commercial Deployment of CSIR-CSMCRI's 'Zero Waste' Spent Wash Management Technology - Potash Fertiliser & Regulatory Compliance |
| 47 | CSIR-IICT   | Development of vapour phase catalytic ammoxidation processes for the synthesis of aromatic nitriles                                               |
| 48 | CSIR-IICT   | Development of Process for Pharmaceutical grade Hydroxy Propyl Methyl Cellulose (HPMC)                                                            |
| 49 | CSIR-IICT   | Development of process for production of 4-methoxy acetophenone in a continuous single-step process                                               |
| 50 | CSIR-NCL    | Synthesis of bio-derived 2,5-furan dicarboxylic acid (FDCA) as analogue to Purified terephthalic acid (PTA)                                       |
| 51 | CSIR-NCL    | Process for the catalytic dehydration of methanol (MeOH) to dimethyl ether (DME)                                                                  |
| 52 | CSIR-NEIST  | Development of an efficient and cost-effective process for production of Caffeine and Tannins from Tea Waste                                      |
| 53 | CSIR-NIIST  | Fluorescent Pigments for Currency Application                                                                                                     |
| 54 | CSIR-CECRI  | Design and Development of Indigenous Smart Battery Management System for Energy Storage and E-vehicle applications                                |
| 55 | CSIR-CECRI  | Development of 250W direct methanol fuel cell stack with in-house                                                                                 |

|    |             | Nafion based hybrid membranes for portable and strategic applications                                                                                                                                                       |
|----|-------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 56 | CSIR-CECRI  | Fabrication of 12V, 500F supercapacitor device assembly                                                                                                                                                                     |
| 57 | CSIR-CECRI  | Refurbished cathode material from spent lithium-ion batteries: a direct approach towards renewable feed stock                                                                                                               |
| 58 | CSIR-CIMFR  | Pilot scale demonstration of coal mine water usage for commercial algal production for food - fertilizer in hybrid photo-bioreactor for combating malnutrition                                                              |
| 59 | CSIR-IIP    | Vacuum Swing Adsorption (VSA) Process for Up-gradation of Bio- gas to Bio-methane Meeting BIS Specification for Bio-PNG and CBG Applications                                                                                |
| 60 | CSIR-NIIST  | Indigenous Fabrication of Transparent Conducting Oxide (TCO) Coatings by Spray Pyrolysis for Dye Sensitized Solar Cell Application                                                                                          |
| 61 | CSIR-NIIST  | Translating Electrochromic Devices to 1'×1' Dynamic Windows: Towards Industrial Smart Glass Technologies                                                                                                                    |
| 62 | CSIR-AMPRI  | Development of Bamboo Composite Beams and their specifications for engineering applications                                                                                                                                 |
| 63 | CSIR-CFTRI  | A cost-effective process of preparation of arabinoxylan from wheat bran and its incorporation in low dietary fiber food products for their commercial application                                                           |
| 64 | CSIR-CFTRI  | Development of export protocol (sea route) for fresh pineapples                                                                                                                                                             |
| 65 | CSIR-CFTRI  | Minimally processed fruits with extended shelf life                                                                                                                                                                         |
| 66 | CSIR-CFTRI  | Production of Isomaltooligosaccharides (IMO) using indigenous transglucosidase from primary and secondary starch sources                                                                                                    |
| 67 | CSIR-CIMAP  | Commercilaization of 'CIM-Pushti': Withanolide-A rich, Leaf Blight tolerant high yielding variety of Ashwagandha (Withania somnifera) with good root textural quality                                                       |
| 68 | CSIR-CIMAP  | Scale-up process for isolation of ricinoleic acid from castor oil and its biotransformation to food-flavor perspective (+)-g-decalactone using Candida strain                                                               |
| 69 | CSIR-CIMFR  | Pilot scale demonstration of 'silica composite 'Si-Bps- HAs' (Silica- Botanical pesticides-Humic acid) from coal ash/biomass ash/biogenic silica rich resources as bio-pesticide for agricultural/store grain pests control |
| 70 | CSIR-CMERI  | Design and Development of Retractable-Roof Poly House                                                                                                                                                                       |
| 71 | CSIR-CSMCRI | Cost effective sustainable process for microalgal based γ-linolenic acid production from microalgae through biorefinery approach                                                                                            |
| 72 | CSIR-IHBT   | Development of botanical formulation using Artemisia maritima extract for the control of aphids in cabbage/cowpea (DBAM)                                                                                                    |

|   73. | CSIR-IHBT              | Development of microalgae based protein and micronutrient rich animal feed                                                                                                                                                                                                                     |
|-------|------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    74 | CSIR-IHBT              | Development of processes for edible and industrial dyes from plant sources for enhanced income                                                                                                                                                                                                 |
|    75 | CSIR-IHBT              | Up-scaled production of disease free corms of saffron (Crocus sativus)                                                                                                                                                                                                                         |
|    76 | CSIR-IICT              | Agri-waste Biorefinery for Microcrystalline cellulose, Reducing Sugars and Lignin Recovery                                                                                                                                                                                                     |
|    77 | CSIR-IIP               | Techno-economic analysis of xylitol production from lignocellulosic biomass using whole-cell biocatalyst                                                                                                                                                                                       |
|    78 | CSIR-IMMT              | Production of Potash, Sulfur And Phosphorus Enriched Biochars Utilising Biomass And Fertiliser Industries Waste                                                                                                                                                                                |
|    79 | CSIR-NBRI              | Bioefficacy and Toxicity data generation for CIB registration of microbial formulations applicable for the biological control of Fusarium diseases in different crops                                                                                                                          |
|    80 | CSIR-NBRI              | Field trial for early maturity of cotton using Anacardic Acid formulation and CIB registration of the product                                                                                                                                                                                  |
|    81 | CSIR-NBRI              | Preparation of Certified Reference Material of important phytomolecules                                                                                                                                                                                                                        |
|    82 | CSIR-NIIST             | Design & development of prototype solar dehumidified drier for cost effective drying of agricultural products                                                                                                                                                                                  |
|    83 | CSIR-CDRI              | IND enabling studies and development of CDRI-4655 as anti-hyper triglyceridemic formulation                                                                                                                                                                                                    |
|    84 | CSIR-CDRI              | Development of new Smac Mimetic against chemotherapy resistant colon cancer                                                                                                                                                                                                                    |
|    85 | CSIR-IICT              | Developing a novel effective therapeutic agent targeting pancreatic and renal cell carcinoma                                                                                                                                                                                                   |
|    86 | CSIR-IMTECH            | Preclinical studies and process development for production of Tridecaptin M, an antibiotic against colistin resistant Gram negative bacterial infections (AGNI)                                                                                                                                |
|    87 | CSIR-IHBT              | Preclinical Efficacy Validation in Non-human Primate Stroke Model of Anti-thrombin-Clot Specific Streptokinase (ACSSK), with dual properties of fibrin specific clot dissolution and prevention of arterial re-occlusion, for the treatment of acute myocardial infarction and Ischemic Stroke |
|    88 | CSIR-NIIST             | Customized Portable Raman spectrophotometric device for multiplex detection of breast cancer biomarkers                                                                                                                                                                                        |
|    89 | CSIR-CSMCRI CCMB CECRI | Homocysteine Specific Novel Sensor for Diagnostic Use                                                                                                                                                                                                                                          |
|    90 | CSIR-IGIB              | Development and pilot implementation of a genetic information                                                                                                                                                                                                                                  |

|     |             | access and analysis system for genetic diseases (GENOMEAPP)                                                                         |
|-----|-------------|-------------------------------------------------------------------------------------------------------------------------------------|
|  91 | CSIR-IGIB   | Radiological AI system for Parallel Informatic Detection of Clinical Triage emergencies (RAPID-CT): Phase 2                         |
|  92 | CSIR-NBRI   | A novel herbal product for vulvovaginal candidiasis                                                                                 |
|  93 | CSIR-CSIO   | Electrostatic dust mitigation and environment protection device                                                                     |
|  94 | CSIR-CSMCRI | Technology for single stage seawater antifouling RO membrane modules and rejuvenation of the same at the end of their life          |
|  95 | CSIR-CSMCRI | Advanced Water Treatment System of Antifouling Hollow Fiber and Nanofiltration Membranes                                            |
|  96 | CSIR-CSMCRI | Development of electro-deionization (EDI) system for continuous production of medical grade ultrapure water                         |
|  97 | CSIR-CSMCRI | Development of indigenous high performance membrane separator for redox flow batteries                                              |
|  98 | CSIR-NEERI  | RISK-PiNET Contaminant Intrusion Point Detection Tool for Water Distribution System -Field implementation and Commercialization     |
|  99 | CSIR-CIMFR  | Investigation into permeable liner for disposal of coal ash in ash disposal ponds                                                   |
| 100 | CSIR-NIIST  | Reactive Gel-Curing Process for Transforming Environmentally Threatening Industrial Solid Wastes into High Value Building Materials |

FBR/NCP Projects implemented during Financial Year  2018-2020

|   S.No | CSIR Lab   | FBR/NCP Projects                                                                                                                                                                                                      |
|--------|------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|      1 | CSIR-AMPRI | High performance metal matrix composites for transportation, defense, aerospace and engineering sectors                                                                                                               |
|      2 | CSIR-AMPRI | Additive Manufacturing of Graphene reinforced metal and polymer composites                                                                                                                                            |
|      3 | CSIR-AMPRI | Hierarchical Reinforcement Approach for improved ILSS of CFRP                                                                                                                                                         |
|      4 | CSIR-AMPRI | Prospects in Development of Magnesium Alloys for engineering and biological applications                                                                                                                              |
|      5 | CSIR-AMPRI | Development of Metallic foam for biological, thermal and engineering applications                                                                                                                                     |
|      6 | CSIR-AMPRI | Electrical insulating Hybrid Composite Sheet using Industrial Inorganic Wastes                                                                                                                                        |
|      7 | CSIR-CCMB  | Apomixis Technologies for Increasing Agricultural Production                                                                                                                                                          |
|      8 |            | Towards product development in rice using mutants that have traits of agronomic importance                                                                                                                            |
|      9 |            | Genome sequencing of the halophyte Salicornia brachiata CC+E1+A13:N13                                                                                                                                                 |
|     10 |            | Genome Regulatory Elements and the Evolution of Complexity                                                                                                                                                            |
|     11 |            | Mechanistic and functional role of a 'Chiral Proofreading' variant in Animalia                                                                                                                                        |
|     12 |            | Genomics and epigenetics in health and disease (GEHeaD)                                                                                                                                                               |
|     13 |            | Mechanistic insights into bacterial growth and morphogenesis                                                                                                                                                          |
|     14 |            | Generation of monoclonal antibodies for research and diagnostics.                                                                                                                                                     |
|     15 |            | Generation of Hepatic organoids by tissue engineering approaches                                                                                                                                                      |
|     16 |            | Tissue Engineering of cartilage and IVD for arthritic and disc degeneration problems                                                                                                                                  |
|     17 | CSIR-CDRI  | Investigating chemical therapeutic space and determinants of survival and virulence in malaria [ParaDIgM]                                                                                                             |
|     18 | CSIR-CDRI  | Development of identified lead molecule as novel anti-leishmanial therapeutic agent                                                                                                                                   |
|     19 | CSIR-CDRI  | Development of therapeutics against skeletal targets to improve bone health                                                                                                                                           |
|     20 | CSIR-CDRI  | Dissecting the architecture and molecular mechanism of multi-protein complexes (BERosomes) involved in DNA Base Excision Repair (BER) repair and Transcription Coupled DNA repair (TCR) pathways from M. tuberculosis |
|     21 | CSIR-CDRI  | Non-alcoholic Steatohepatitis (NASH)                                                                                                                                                                                  |
|     22 | CSIR-CDRI  | Chronic Respiratory Disease Innovation and Solution Program(CRISP)                                                                                                                                                    |
|     23 | CSIR-CDRI  | Development of therapeutics against skeletal targets to improve bone health: therapeutic repurposing of pentoxyfylline                                                                                                |

|   24. |            | Regulatory Development of CDRI Prioritized Lead Compounds                                                                                                                   |
|-------|------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    25 |            | Therapeutics for Lifestyle Disorders [TheraLSD]                                                                                                                             |
|    26 |            | Cell penetrating peptide, IMT-P8 as a drug delivery vehicle in management of MRSA infections (PEPTIDOCURE)                                                                  |
|    27 | CSIR-CEERI | Development of novel compact high power THz device technologies                                                                                                             |
|    28 |            | Development of new generation nano metal-oxide/graphene-polymer composite materials for use in wearable electronics (with CGCRI as implementing lab)                        |
|    29 | CSIR-CECRI | In-silico guided design of Corroision Inhibiting Molecules to Materials (CIM2M)                                                                                             |
|    30 | CSIR-CFTRI | Establishment of 'National Analytical Facility' for analysis of nutraceuticals and chemical markers in food products (NAFANC)                                               |
|    31 |            | Translation of pre-clinically tested probiotic formulation to human population with emphasis on immuno-modulation and gut microflora                                        |
|    32 |            | Understanding structure-function relationships in enzymes critical for the survival of bacterial food pathogens                                                             |
|    33 |            | Data analytics based on diet diversity, food consumption and nutritional deficiency targeted to the selected aspirational districts in Karnataka and Kerala                 |
|    34 | CSIR-CGCRI | Development of Hydrophobic Ceramic Hollow Fiber Membrane for MD-based Domestic Water Purification System                                                                    |
|    35 |            | Chalcogenide glass and fibers for mid infrared photonics applications                                                                                                       |
|    36 |            | Development of surface modified adsorbents with higher sorption capacity for specific contaminants removal in water/ industrial wastewater (SMA).                           |
|    37 |            | 1KW Fiber Laser for Industrial and Strategic Applications (LISA)                                                                                                            |
|    38 |            | Development of new generation nano metal-oxide/graphene-polymer composite materials for use in wearable electronics                                                         |
|    39 | CSIR-CIMAP | DNA-free CRISPR-mediated Genome-editing in rose-scented Geranium                                                                                                            |
|    40 |            | Understanding the biosynthesis of bioactive triterpenes in the medicinal tree banaba (Lagerstroemia speciosa) for the development of yeast-based synthetic biology platform |
|    41 |            | Identification of molecular targets towards improvement of root biomass and/or texture in Withania somnifera                                                                |
|    42 |            | Development of Withanamide enriched high yielding, variety of Ashwagandha (Withaniasomnifera)                                                                               |
|    43 |            | UAV based high resolution remote sensing for modernized and efficient cultivation practices of commercially important medicinal and aromatic crops. (Acronym: DroneAgri)    |
|    44 | CSIR-CIMFR | Preparation of in-situ stress map of Jharia Coalfield                                                                                                                       |
|    45 |            | Catalytic Petcoke Gasification                                                                                                                                              |
|    46 |            | Studies on Sorption-Induced Strain and Permeability Changes in Coal and Shale as a Result of CO2 Injection                                                                  |
|    47 | CSIR-CMERI | Development of multifunctional care device for army personnel                                                                                                               |
|    48 |            | Indigenous development of LRUs suitable for small aircraft                                                                                                                  |

|    |             | (InDeLiRU)                                                                                                                                                               |
|----|-------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 49 |             | Robotic Inervention for Industrial and Strategic Applications                                                                                                            |
| 50 | CSIR-CLRI   | Polymer Filaments for 3D printing                                                                                                                                        |
| 51 | CSIR-CRRI   | Develoment of Rejuvenating Agent (RA) for use in recycling of Asphalt Pavements RAP                                                                                      |
| 52 | CSIR-CRRI   | Cold Mix Technology for High Volume Roads                                                                                                                                |
| 53 | CSIR-CRRI   | Upgradaton of Half Warm Mix Technology for Construction and Maintenance of Bitminous Surfacing                                                                           |
| 54 | CSIR-CSIO   | Design & Development of Angle Independent Multilayer Thin Film Filter (AIMTF) on Foldable and Military Grade Optical Optical Substrates                                  |
| 55 | CSIR-CSIO   | Design and development of precision optics for soft X-Rays                                                                                                               |
| 56 | CSIR-CSIO   | Magnetic Graphene Coated Polymeric Stationary Phase Ion- Exchangers for Ion Chromatography Column Separations                                                            |
| 57 | CSIR-CSIO   | Low cost functional materials in Selenium Detection in Water                                                                                                             |
| 58 | CSIR-CSIO   | Photonic meta-surfaces for smart applications                                                                                                                            |
| 59 | CSIR-CSIO   | Development of multifunctional care device for army personnel                                                                                                            |
| 60 | CSIR-CSIO   | Energy Management using Non Intrusive Load Monitoring (NLIM) Technique                                                                                                   |
| 61 | CSIR-CSIO   | Development of Customized Flow Hive for quality Honey Harvesting &Extraction                                                                                             |
| 62 | CSIR-CSIO   | Development of Mobile-Soil-Sensing-System and Digital Spatial Repository for Precision Agriculture using Fusion of Proximity Sensors and Geo-statistics Modelling        |
| 63 | CSIR-CSMCRI | Indigenously developed reverse electrodialysis process for salinity gradient based power generation                                                                      |
| 64 | CSIR-CSMCRI | Genome sequencing of the halophyte Salicornia brachiata                                                                                                                  |
| 65 | CSIR-IGIB   | Mechanistic basis of IncRNA mediated regulation in organ development and function (DevoRNA)                                                                              |
| 66 | CSIR-IGIB   | Decoding telomerase reactivation in cancer - molecular mechanisms of G-quadruplex-mediated telomerase (hTERT) control                                                    |
| 67 | CSIR-IGIB   | Chronic Respiratory Disease Innovation and Solution Program(CRISP)                                                                                                       |
| 68 | CSIR-IGIB   | Genomics and epigenomics in health and disease (GEHeaD)                                                                                                                  |
| 69 | CSIR-IGIB   | GEAR - Genomic, Evolutionary and Big Data Analytic strategies to address antimicrobial resistance                                                                        |
| 70 | CSIR-IGIB   | GRAFT(Garnering Regenerative Approaches For Transplantation)                                                                                                             |
| 71 | CSIR-IHBT   | Development of high-throughput genotyping platform for next genereration plant breeding in tea                                                                           |
| 72 | CSIR-IHBT   | characterization and development of agro and process technology for low calorie natural sweetener (Siraitia grosvenorii)                                                 |
| 73 | CSIR-IHBT   | Exploration of Himalayan Plants for Novel Antimalarial Agents: Characterization of potential molecules                                                                   |
| 74 | CSIR-IHBT   | UAV based high resolution remote sensing for modernized and efficient cultivation practices of commercially important medicinal and aromatic crops. (Acronym: DroneAgri) |

|      | 75. 76.   | Molecular mechanism underlying Apple scar skin viroid-whitefly interaction                                                                                  |
|------|-----------|-------------------------------------------------------------------------------------------------------------------------------------------------------------|
|      | 75. 76.   | Development of process for converting raw cellulosic biomass into textile fiber and nanocellulose                                                           |
| 77.  | 75. 76.   | Creation of aroma bank by utilization of western Himalayan biodiversity (AROMA-BANK)                                                                        |
| 78.  | 75. 76.   | Bisoprospection Microbiome from Himalayan niches                                                                                                            |
| 79.  | 75. 76.   | Non-invasive technology for production of naphthoquinone pigments from Arnebia species on sustainable basis                                                 |
| 80.  | 75. 76.   | conservation and sustainable resource generation of high altitude bioresources at CSIR - Centre for High Altitude Biology                                   |
| 81.  | CSIR-IICB | EXOsomal MIRna Inhibitor: Identification of the new classes of inhibitors of miRNA trafficking via exosomes (EXOMIRIN)                                      |
| 82.  | CSIR-IICB | Non-alcoholic Steatohepatitis (NASH)                                                                                                                        |
| 83.  | CSIR-IICB | Chronic Respiratory Disease Innovation and Solution Program(CRISP)                                                                                          |
| 84.  | CSIR-IICB | Genomics and epigenomics in health and disease (GEHeaD)                                                                                                     |
| 85.  | CSIR-IICT | Non-destructive depth profiling and identification of debonding defects across polymer interfacial layers by using portable single- sidedNMR                |
| 86.  | CSIR-IICT | Development of hybrid flocculants at 100 g scale for selective adsorption of low grade iron ore slimes and fines to recover iron ore more than 80 %.        |
| 87.  | CSIR-IICT | Sustainable production of Edible oils from Microalgae                                                                                                       |
| 88.  | CSIR-IICT | Scale up of materials for Dye Sensitized Solar Cells and Organic Photovoltairs                                                                              |
| 89.  | CSIR-IICT | Mimicking Muscles: Electroactive Polymers for Bionics                                                                                                       |
| 90.  | CSIR-IICT | Vegetable oil-based Gels as trans free fat (Oleogel)                                                                                                        |
| 91.  | CSIR-IICT | Chronic Respiratory Disease Innovation and Solution Program(CRISP)                                                                                          |
| 92.  | CSIR-IICT | Autologous Transplantation of Transgenically Modified Hepatic Progenitor Cells expressing therapeutic genes-mediated Liver Regeneration (PROMPT)            |
| 93.  | CSIR-IICT | Enzymatic Process for the prepoaration of API intermediates                                                                                                 |
| 94.  | CSIR-IICT | Accelerated Wound Healing by Bone marrow Stem Cells delivered using PEG-PU porous Polymer Scaffolds Grafted with KGF- and/or VEGF- Mimetic Peptides (GRAFT) |
| 95.  | CSIR-IIP  | Modeling of mono/bi-metallic catalysts for hydroprocessing reactions                                                                                        |
| 96.  | CSIR-IIP  | Carboxylation of naphtha grade olefins to high value chemicals using CO2                                                                                    |
| 97.  | CSIR-IIP  | Catalytic oxidation of propylene to propylene oxide                                                                                                         |
| 98.  | CSIR-IIP  | Methane Transformation over Nanostructured Catalyst                                                                                                         |
| 99.  | CSIR-IIP  | Process/catalyst development for reduced hydrogen consumption for the hydrocracking of renewable oils (HLess-HCRO)                                          |
| 100. | CSIR-IIP  | Catalytic process for the production of BTX/gasoline from bio- naphtha                                                                                      |

|      | 101.       | Electric Conversion of High Polluting Diesel/Petrol 3W, 4W Vehicles in Electric Vehicles and Development of Solar Charging Station                                                                                         |
|------|------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 102. | CSIR- IMMT | Green synthesis of Silver nanoparticles against plant pathogens: An alternative solution for chemical pesticides                                                                                                           |
| 103. | CSIR- IMMT | Developing magnetic refrigerant materials for cooling applications at cryogenic temperatures-(MRM)                                                                                                                         |
| 104. | CSIR- IMMT | Sensors for detection of heavy metal ion contaminations                                                                                                                                                                    |
| 105. | CSIR- IMMT | Dephosphorization of high phosphorus iron ore                                                                                                                                                                              |
| 106. | CSIR- IMMT | Ferro Manganese production from lean grade Manganese ore                                                                                                                                                                   |
| 107. | CSIR- IMMT | Processing of Mineral & Metallurgical Wastes, and Flyash for their value addition                                                                                                                                          |
| 108. | CSIR- IMMT | Kinetics and thermodynamics study on reduction roasting of low and lean grade iron ores using fluidized bed roaster to maximise the recovery of iron values                                                                |
| 109. | CSIR- IMMT | Thermodynamics and kinetics study of ferruginous ilmenite reduction and smelting for production of titania slag                                                                                                            |
| 110. | CSIR- IMMT | Highly Ordered Functionalized Nano structured Electrolytic Manganese Dioxide with enhanced electrochemical performance for Batteries and Supercapacitors                                                                   |
| 111. | CSIR- IMMT | Protective conducting materials coating of La0.6Sr0.4Co0.2Fe0.8O3 (LSCF), MnCo2O4 and Mn1.5Co1.5O4 on SOFC interconnect Crofer 22 APU by Electrophoretic deposition to mitigate high temperature oxidation and degradation |
| 112. | CSIR- IMMT | Development of Active Noise Control Chair for Aircraft Cabin                                                                                                                                                               |
| 113. | CSIR- IMMT | Preparation of coke and ferro-coke from low ash non-coking coal                                                                                                                                                            |
| 114. | CSIR- IMMT | Recycling of spent battery materials for value addition                                                                                                                                                                    |
| 115. | CSIR- IMMT | Solvatometallurgical extraction of Cu and Zn from low grade ores and secondaries through Deep Eutectic Solvents(DES)                                                                                                       |
| 116. | 117. 118.  | Identification of Missing Phosphatase in Metabolic Pathway (IMP2)                                                                                                                                                          |
|      | 117. 118.  | Evolutionary studies on Flexibility and Function of Lipid-bound efflux proteins for Understanding eXtreme drug resistance in microbes ( EFFLUX)                                                                            |
|      | 117. 118.  | GEAR-Genomic, Evolutionary and Big Data Analytic strategies to address antimicrobial resistance                                                                                                                            |
| 119. | 117. 118.  | Cell penetrating peptide, IMT-P8 as a drug delivery vehicle in management of MRSA infections (PEPTIDOCURE)                                                                                                                 |
| 120. | 117. 118.  | Developing high yielding CHO cell clone producing the anti-RSV mAb                                                                                                                                                         |
| 121. | 117. 118.  | Development of mass spectral library for characterization of recombinant therapeutic monoclonal antibodies (MSLAb)                                                                                                         |
| 122. | 117. 118.  | Mega-genomic insights into co-evolution of rice and its microbiome                                                                                                                                                         |
| 123. | 117. 118.  | Exploring the Indian coastal and marine biodiversity for discovery and production of industrially important microbial proteins                                                                                             |
| 124. | 117. 118.  | Development of a microbial system for the production of neo- glycopeptides/ neo-glycoproteins for useful applications                                                                                                      |

|   125. | CSIR-NAL   | Aerodynamic studies of aircraft configurations including wing- propeller interaction                                                                                                                            |
|--------|------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    126 | CSIR-NAL   | Development of Aeroelastic Algorithms in Aircraft Design                                                                                                                                                        |
|    127 | CSIR-NAL   | Environment Establishment for generating Flight Worthy Code from the Display Simulator Code                                                                                                                     |
|    128 | CSIR-NAL   | Tailoring of Carbon Fiber Reinforced Composites for Enhanced Heat Dissipation Capability, Mechanical Properties and Electrical Conductivity using Carbon Nanotubes /Carbon Materials for Aerospace Applications |
|    129 | CSIR-NAL   | Active Thermal Imaging for Non-destructive Evaluation (NDE) of thin composite aircraft structures                                                                                                               |
|    130 | CSIR-NAL   | Certification of 30 HP Indigenous Wankel Rotary Combustion Engine                                                                                                                                               |
|    131 | CSIR-NAL   | Design and Development of Integrated Avionics Display Processing Computer(IADC)                                                                                                                                 |
|    132 | CSIR-NAL   | Development of Airboat (JALDOST)                                                                                                                                                                                |
|    133 | CSIR-NAL   | Development of Active Noise Control Chair for Aircraft Cabin                                                                                                                                                    |
|    134 | CSIR-NAL   | Iron Bird Technology Platform for Evaluating Aircraft Actuation Systems                                                                                                                                         |
|    135 | CSIR-NAL   | UAV based high resolution remote sensing for modernized and efficient cultivation practices of commercially important medicinal and aromatic crops. (Acronym: DroneAgri)                                        |
|    136 | CSIR-NBRI  | Small RNAs and Associated factors for enhanced post-harvest Life (sRNA-life)                                                                                                                                    |
|    137 | CSIR-NBRI  | Pathway elucidation and identification of genes involved in guggulsterones biosynthesis in Commiphora sps                                                                                                       |
|    138 | CSIR-NBRI  | Sub-genome dominance in endoreduplication and its implication in heterotic benefits to F1-hybrids for biomass and their adaptation                                                                              |
|    139 | CSIR-NBRI  | Understanding the epigenetics of fitness advantage of high altitude Arabidopsis thaliana populations under new environments                                                                                     |
|    140 | CSIR-NBRI  | Genome-editing for enhanced yield and quality traits (GE-plant)                                                                                                                                                 |
|    141 | CSIR-NBRI  | Characterization and value addition of plant-based resins, gums and waxes                                                                                                                                       |
|    142 | CSIR-NCL   | Nanofiber membrane of PET-cellulose derivative immobilized with nanocomposites as separators in lithium ion battery                                                                                             |
|    143 | CSIR-NCL   | Design and Development of Indigenous Strain Portfolio for the Production of Penicillin V (PenV-IP)                                                                                                              |
|    144 | CSIR-NCL   | Scalable synthesis of multifunctional nanomaterials for advanced applications (batch processing/flow synthesis                                                                                                  |
|    145 | CSIR-NCL   | Towards Large Scale Solar Hydrogen Production (SoHy)                                                                                                                                                            |
|    146 | CSIR-NCL   | Insight into cell physiology for cell culture medium formulation                                                                                                                                                |
|    147 | CSIR-NCL   | Development of mass spectral library for characterization of recombinant therapeutic monoclonal antibodies (MSLAb)                                                                                              |
|    148 | CSIR-NCL   | In-silico guided design of Corroision Inhibiting Molecules to Materials (CIM2M)                                                                                                                                 |
|    149 | CSIR-NEERI | Estimation of Ecosystem Services and Environmental Damage Cost                                                                                                                                                  |

|     |            | Due to Climate Change: Biodiversity Perspective                                                                                                                                                                                    |
|-----|------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 150 |            | Understanding Critical Zone Structure: WRJ-1 Critical Zone Observatory                                                                                                                                                             |
| 151 |            | Waste to Wealth                                                                                                                                                                                                                    |
| 152 | CSIR-NEIST | Utilization of North East Region (NER), India clay minerals for ceramic applications                                                                                                                                               |
| 153 | CSIR-NEIST | Value addition of non-timber wood available in the North Eastern region of India by chemical modification for different industrial applications                                                                                    |
| 154 | CSIR-NEIST | Plasmonic nanoparticles decorated 2D nanosheets for detection of the fluoride and arsenic in drinking water: Fabrication of a paper strip based analytical device                                                                  |
| 155 | CSIR-NEIST | Ammonia from dinitrogen at ambient condition by new advanced material: a potential energy saving process than Haber-Bosch                                                                                                          |
| 156 | CSIR-NEIST | Development of brown spot (Drechsleraoryzae) disease tolerance in rice through multiplex-multi-gene CRISPR-Cpf1 genome editing system                                                                                              |
| 157 | CSIR-NGRI  | Geodynamics and Metallogeny of parts of the East Indian Shield with specific reference to Diamond, Iron Ore &Chromitite-PGE occurrences (GeoMet)                                                                                   |
| 158 | CSIR-NGRI  | Synthesis of Earthquake Hazard scenario in NWHimalaya by Investigating the multi-scale Variations in structural and seismotectonic Assemblages (SHIVA)                                                                             |
| 159 | CSIR-NIIST | Development of Mn-based RE-free intermetallic permanent magnets for automotive and energy generation                                                                                                                               |
| 160 | CSIR-NIIST | Exploring in-situ synthesis for Titanium Metal Powder by direct reduction of synthetic rutile                                                                                                                                      |
| 161 | CSIR-NIIST | Development of Warm White Light Emitting Single Phased Oxyfluoride Phosphors for Energy Efficient and High Color Rendering LEDs                                                                                                    |
| 162 | CSIR-NIIST | Deciphering the microbiome of native wild coastal saline tolerant rice varieties of southern India and understanding the impact of seawater in structuring the root associated core microbiota using pokkali rice as a model plant |
| 163 | CSIR-NIIST | Chromogenic Materials for Smart Coating Applications                                                                                                                                                                               |
| 164 | CSIR-NIO   | Impact of Climate Change on the Physics, Biogeochemistry, and the Ecology of the North Indian Ocean (CliCNIO)                                                                                                                      |
| 165 | CSIR-NIO   | Enhancing live stocks of herbivore fishes through captive breeding to control the macroalgal dominance in coral reefs to sustain the fishing revenue                                                                               |
| 166 | CSIR-NML   | Self-healing Coatings for Corrosion Protection of Steel &Aluminium alloys                                                                                                                                                          |
| 167 | CSIR-NML   | Synthesis of new 2D materials other than graphene for energy application                                                                                                                                                           |
| 168 | CSIR-SERC  | Development of Methodologies for Remaining Life Assessment and Risk-based Inspection Scheduling of Piping Systems under Corrosive Environment (ReLife-InS)                                                                         |

|   169. |          | Multi-scale damage characterization of laminated FRP composites under fatigue loading   |
|--------|----------|-----------------------------------------------------------------------------------------|
|    170 |          | Development of composite Bridge Deck Systems for Fast Track construction                |
|    171 | CSIR-4PI | Carbon and Nitrogen cycling in the Earth Sciences (CNCES)                               |

## Ongoing FBR/NCP Projects (Financial Year 2020-2022)

|   1. | CSIR-NCL   | Phagocytosis of full-length Tau oligomers by actin-remodelling of activated microglia                                                                                                                           |
|------|------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    2 | CSIR IICB  | Deriving a pan-omics diagnostic pipeline for systems level immune health and therapeutic targeting in systemic autoimmunity                                                                                     |
|    3 | CSIR IICB  | Leishmaniasis: target specific approches to affect host-pathogen interaction and disease process                                                                                                                |
|    4 | CSIR IICB  | Modern innovative solutions for environmental/ occupational lung health challenges using clinical and pre -clinical strategies                                                                                  |
|    5 | CSIR IICB  | Non-alcoholic fatty liver disease (NAFLD): Novel pathogenic mechanism and therapeutic development                                                                                                               |
|    6 | CSIR IICB  | Targeting RNA driven processes: Novel chemical biology approches to identify new classes of RNA modulators                                                                                                      |
|    7 | CSIR IICB  | Exploring role of mechanical cues in immunocellular regulation                                                                                                                                                  |
|    8 | CSIR -IICB | Mechanistic understanding of role of human ZMYND8 in tumor microenvironment-dependent transcriptional reprogramming leading to metastasis in colorectal cancer                                                  |
|    9 | CSIR IICB  | Restoration of p53 and Rb through targeting their post-translational modifiers (PTM) HAUSP and MDM2 in glioma and stepping towards development of novel inhibitory peptide designing from interacting interface |
|   10 | CSIR IICB  | Theranostic approach in Glioblastoma Multiforme (GBM) using engineered oncolytic Virus derived particles (VDPs)                                                                                                 |
|   11 | CSIR-IICT  | Chemically induced degradation of proteins using proteolysis targeting chimera (PROTAC) molecules                                                                                                               |
|   12 | CSIR-IICT  | Strategies to ameliorate neurodegenerative disorders: mitochondria targeting agents for disease modifying role                                                                                                  |
|   13 | CSIR-NGRI  | Probing the Structure and Kinematics of the NW Himalaya for Assessment of Earthquake Hazard Potential                                                                                                           |
|   14 | CSIR-NGRI  | Geodetic measurements for crustal deformation Along a N-S Transect in India                                                                                                                                     |
|   15 | CSIR-NEIST | Earthquake Hazard Studies in Moderate and Severe Seismic Zones                                                                                                                                                  |
|   16 | CSIR-4PI   | Integration of GNSS and Broadband data for high resolution velocity structure and crustal deformation in Jammu, Kashmir and Ladakh Himalaya                                                                     |
|   17 | CSIR-NGRI  | Structure, Anatomy and Geological Evolution of the Singhbhum Mobile Belt, Singhbhum Craton, East India (SIMO)                                                                                                   |
|   18 | CSIR-NGRI  | Hydro- Mechanical Modelling in Seismically active Koyna- Warna region, Maharashtra, India                                                                                                                       |
|   19 | CSIR-NGRI  | Electrical Vector Resistivity Imaging (EVRI): a novel method for 3D subsurface mapping                                                                                                                          |
|   20 | CSIR-NGRI  | To Develop Capability in Multicomponent, Long-Offset Seismic Data Acquisition with increased seismic bandwidth 10 to 200Hz                                                                                      |
|   21 | CSIR-NIO   | Focused Research on specialized ecosystems in the South Eastern Arabian Sea for sustainable utilization and management of resources (FoRSEAS)                                                                   |

|   22. | CSIR-NIO                  | Long-term evolution of monsoon and associated processes                                                                                      |
|-------|---------------------------|----------------------------------------------------------------------------------------------------------------------------------------------|
|    23 | CSIR-NIO                  | Influence of methane/methane hydrate on ecology and biodiversity at the methane seep locations in Indian EEZ                                 |
|    24 | CSIR-NIO                  | Study on the nature and formation of Ramsethu & its surrounding environment.                                                                 |
|    25 | CSIR-NIO                  | Tectonic and magmatic processes along the slow-spreading mid- oceanic ridges and subduction zone in the Indian Ocean                         |
|    26 | CSIR-NIO                  | Interactions between trace metals and marine biota in the Indian Ocean                                                                       |
|    27 | CSIR-NEERI                | Assessing influence of open and closed drain system on ecosystem services using meta-omics approach                                          |
|    28 | CSIR-NEERI                | Mapping of the impacts of Climate Change (Extreme weather events) on critical health and social care systems in Aspirational Districts (ADs) |
|    29 | CSIR-NEERI                | Understanding Food-Energy-Water Nexus in Dynamics of Critical Zone: WRJ-1 Critical Zone Observatory                                          |
|    30 | CSIR-NGRI                 | Development of new technologies for Seismic Image Enhancement and fine scale Subsurface VELocity structure                                   |
|    31 | CSIR-NIO                  | Synergizing marine ecology with bioprospecting: Harnessing marine living resources for products and bioprocesses 'BIOPROSmar'                |
|    32 | CSIR-NIO                  | Ecological processes and prediction of coastal pollution in Mumbai waters                                                                    |
|    33 | CSIR-4PI                  | Development of a modelling platform for Hydro-meteorological Disaster early Warning System for major metro cities in India                   |
|    34 | CSIR-AMPRI                | Development of 3-D printer for additive construction of scaled model of building and construction material optimization                      |
|    35 | CSIR-AMPRI                | Development of polymer / geopolymer based nanocomposites for antimicrobial coating applications                                              |
|    36 | CSIR-CBRI with CSIR-CIMFR | Geotechnical Novel Solutions for Underground Infrastructures                                                                                 |
|    37 | CSIR-CBRI                 | Spalling-mitigation solution of self-compacting high-strength concrete at elevated temperature condition using recycled tire's polymer fiber |
|    38 | CSIR-CBRI                 | Development of Innovative cool roof with improved thermal & energy performance                                                               |
|    39 | CSIR-CBRI                 | Structural Performance Assessment of Connections in Bamboo Structures                                                                        |
|    40 | CSIR-CBRI                 | Multi-temporal Optical Imaging Drone based Landslide Monitoring and Warning                                                                  |
|    41 | CSIR-CIMFR                | Roof rock reinforcement system (R3S) for mine roadways intersection under varying geomining conditions.                                      |
|    42 | CSIR-CMERI                | Development of Ultra-precision Co-ordinate Measuring Machine (UCMM) with sub-micron range uncertainty                                        |
|    43 | CSIR-CRRI with CSIR-NPL   | Development of prefabricated plastic panels for road construction                                                                            |
|    44 | CSIR-CRRI                 | Development of Trip Generation Manual for Indian Cities                                                                                      |
|    45 | CSIR-SERC                 | Performance Based Retrofitting of Ageing Infrastructure (Existing Bridges, Power Plant Structures &Transmission Line Towers)                 |
|    46 | CSIR-SERC                 | Engineering of Large Floating Offshore Structures and Systems for                                                                            |

|    |            | Renewable Energy Farming                                                                                                                                                               |
|----|------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 47 | CSIR-SERC  | Advanced Cementitious Composites for 3D printing                                                                                                                                       |
| 48 | CSIR-SERC  | Nondestructive Testing and Evaluation of Submerged Concrete Structures                                                                                                                 |
| 49 | CSIR-SERC  | Phase-Field Approach for Prediction of Crack Initiation and Growth in Structural Components                                                                                            |
| 50 | CSIR-SERC  | Methodologies for prediction of Fatigue damage and remaining life assessment of Latticed Transmission line towers due to wind loads                                                    |
| 51 | CSIR-SERC  | Development of novel Electrically Conductive concrete utilizing high carbon content industrial solid wastes                                                                            |
| 52 | CSIR-AMPRI | Development of special radiation shielding materials                                                                                                                                   |
| 53 | CSIR-AMPRI | Bio-Inspired Surface Functionalization of Carbon Nanostructures with Catecholamine/Catechol Rich Polymers: Novel Approach to Develop Advance Biosensors                                |
| 54 | CSIR-AMPRI | High strength creep and corrosion resistance Magnesium - RE-TE Alloy, composite and foams for Engineering and strategic sectors                                                        |
| 55 | CSIR-AMPRI | Advanced Protecting of Magnetic Storage and Bio-Medical Systems using Smart Thin Film Materials                                                                                        |
| 56 | CSIR-AMPRI | Design and development of Smart, Hybrid Polymer Composites and Structures For Advanced Engineering Applications                                                                        |
| 57 | CSIR-AMPRI | Functional bio-degradable polymers with antibacterial properties for tissue engineering applications                                                                                   |
| 58 | CSIR-CECRI | Computationally aided synthesis of artificial receptors: Biomimetic molecularly imprinted polymers (MIPs)                                                                              |
| 59 | CSIR-CECRI | Reclamation of spent platinum group metals utilizing hazardous exhaust from plating baths                                                                                              |
| 60 | CSIR-CGCRI | Advanced Manufacturing of Nanofinished Ceramics and Hard Alloy Components by Laser Assisted Ductile Mode Machining                                                                     |
| 61 | CSIR-CGCRI | Multicomponent glass based optical fibers for Vis-MIR photonic applications                                                                                                            |
| 62 | CSIR-CGCRI | Microwave melting of glass: A potential method for tailoring glass properties.                                                                                                         |
| 63 | CSIR-CGCRI | Demonstration of Pulsed Fiber Laser Sources for Additive Manufacturing and Precision Material Processing                                                                               |
| 64 | CSIR-CGCRI | Development of a biodegradable and biocompatible nano ceramics/bioactive glass-polymer composite material with anti- bacterial properties for use in female sanitary hygiene products. |
| 65 | CSIR-CGCRI | Development of an array based low temperature sensing device for early detection of multiple diseases by monitoring exhaled breath                                                     |
| 66 | CSIR-CGCRI | Development of Low Carbon MgO-C Refractory for Clean Steel Production                                                                                                                  |
| 67 | CSIR-CGCRI | Development of thermally stable and antimicrobial bioactive glass based bone graft material                                                                                            |
| 68 | CSIR-CGCRI | Efficient Supercontinuum Sources in the Mid-IR and Visible-NIR using Photonic Crystal Fibers: Innovative Solutions for Deep- Penetration and Ultrahigh-Resolution OCT                  |
| 69 | CSIR-CGCRI | Development of ultra-low expansion glass-ceramic from low cost resources for application in cooktop panel of LPG gas oven                                                              |

|   70. | CSIR-CGCRI   | Development of Fiber Bragg Grating long gauge sensors for Structural Health Monitoring                                                                                                  |
|-------|--------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    71 | CSIR-CIMFR   | ASSESSMENT OF ROCK BOLTING IN -SITU BY ULTRASONIC GUIDED WAVES FOR HUMAN SAFETY IN UNDERGROUND MINES                                                                                    |
|    72 | CSIR-CMERI   | Development of Scanning Laser Epitaxy (SLE) process                                                                                                                                     |
|    73 | CSIR-CMERI   | Development of Compressed Hydrogen Composite Storage Tank for Fuel Cell Electric Vehicles                                                                                               |
|    74 | CSIR-CSIO    | Advanced Functional Nanosurfaces For Optical Sensing of Emerging Pollutants and Their Removal                                                                                           |
|    75 | CSIR-CSIO    | Dielectric and Magnetic Material based Composite for Microwave Absorption Applications                                                                                                  |
|    76 | CSIR-CSMCRI  | Development of efficient synthetic protocol of high temperature (≥ 1200 °C) stable anatase TiO2: A technological challenge for self- cleaning ceramic tiles industries.                 |
|    77 | CSIR-CSMCRI  | New material & strategy for recognition and removal of toxic Polyaromatic hydrocarbons (PAH4) and 'Dirty dozen' Persistent organic pollutant                                            |
|    78 | CSIR-IIP     | Development of Graphene-Based Materials as Booster Dose Additives to Fully Formulated Engine oil for Enhancement of Lubrication Properties                                              |
|    79 | CSIR-IIP     | Design and development of nanostructured hybridmaterials comprising a semiconductor light harvester and molecular complex for photo- electrochemical reduction of CO2 to methanol       |
|    80 | CSIR-IMMT    | Development of ferro alloys using alternate reductants: syn gas/producer gas, methane, and hydrogen through pyrometallurgical route                                                     |
|    81 | CSIR-IMMT    | Recovery of metal values from FeCr slag en route to zero waste                                                                                                                          |
|    82 | CSIR-IMMT    | Feasibility study on combustion of Petcoke-coal fuel mix in a Fluidized bed reactor (FBR) and reduction of emission through appropriate dosages of chemical reagents during combustion. |
|    83 | CSIR-IMMT    | Recovery of Mn as EMD from low grade ores and secondaries for energy application                                                                                                        |
|    84 | CSIR-IMMT    | Nanometal engrained Agro waste based Dielectric materials for Embedded Capacitors (NanoDEC)                                                                                             |
|    85 | CSIR-IMMT    | Liquid - Liquid - Liquid Extraction and Stripping of Metal Ions in Multi-Helical Flow Reactor                                                                                           |
|    86 | CSIR-IMMT    | Value addition of bauxite mining waste rocks for refractory applications                                                                                                                |
|    87 | CSIR-IMMT    | Development of Green Surfactants for Mineral Flotation and Flocculation: Molecular Level Design, Characterization, and Synthesis (GSMF)                                                 |
|    88 | CSIR-IMMT    | Design of Novel Luminescent Materials For White Light-Emitting Devices Application                                                                                                      |
|    89 | CSIR-IMMT    | Development of Flexible Piezocomposite Materials for Self-Powered Electronics                                                                                                           |
|    90 | CSIR-IMMT    | Multiscale modeling and computational design of high-performance materials for remediation of polluted water                                                                            |

|   91. | CSIR-IMMT   | Synthesis of Calcium sulfo-aluminate: An Eco-cementing material alternate of Portland cement                                                                             |
|-------|-------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    92 | CSIR-NCL    | Understanding Reaction Mechanism of Ethylene Epoxidation                                                                                                                 |
|    93 | CSIR-NCL    | Development of MXene based Composite 2D Nanoengineered Materials for charge storage.                                                                                     |
|    94 | CSIR-NEIST  | Nanozyme Decorated Paper-Based Analytical Devices (µPADs) for Detection of Pathogens and Pesticides                                                                      |
|    95 | CSIR-NEIST  | Development of Microbial based process for Bio-cement, Bio-brick and self-healing concrete using locally available resources.                                            |
|    96 | CSIR-NEIST  | Design and Synthesis of 𝞹 -Extended Carbon Materials for Photonic Applications                                                                                           |
|    97 | CSIR-NEIST  | Eco-friendly process for making anatase grade TiO2 from Low grade ilmenite                                                                                               |
|    98 | CSIR-NEIST  | Exploring biodegradable and biocompatible Magnesium based alloys and coatings for temporary implants                                                                     |
|    99 | CSIR-NEIST  | Conductive Copper Ink for Inkjet Printable Flexible Electronics                                                                                                          |
|   100 | CSIR-NEIST  | Aluminium-Magnesium-Scandium Alloy and Product Development for Aerospace and Strategic Applications.                                                                     |
|   101 | CSIR-NEIST  | Development of lightweight aluminum alloy and functionally graded components for automotive Category and strategic applications                                          |
|   102 | CSIR-NML    | Development of fire resistant lightweight structural materials by hybridization of inorganic-organic polymers                                                            |
|   103 | CSIR-NML    | Process development of high quality layered transition metal carbides/ nitrides/ carbonitrides (MAX)                                                                     |
|   104 | CSIR-NML    | Development of Tin-Selenide (SnSe) based thermoelectric thin films for waste heat recovery in metallurgical and other industries                                         |
|   105 | CSIR-NML    | Development of dry beneficiation process technology for low grade iron ore for iron and steel making                                                                     |
|   106 | CSIR-NML    | Big Data Assimilation and Synthesis for Materials Creep Degradation                                                                                                      |
|   107 | CSIR-NML    | Thermodynamic and kinetic assessment of interfacial equilibrium conditions in multi-component based bulk nano-pearlitic steels.                                          |
|   108 | CSIR-NML    | Development of high ballistic strength armour steel with 2 GPa tensile strength and min 50MPam1/2fracture toughness                                                      |
|   109 | CSIR-NML    | PREPARATION OF COKE FROM NON-COKING COAL                                                                                                                                 |
|   110 | CSIR-NPL    | Establishment of parameters for certain ferrous and nonferrous Alloys and Specialized Polymers for developing their standards & Life Cycle Extension                     |
|   111 | CSIR- CECRI | Tailoring the graphene reinforced PEEK composite-based filament for 3D printable aerospace structural components                                                         |
|   112 | CSIR-CEERI  | Development of high emission density nanotechnology based scandate cathode for high power mmwave devices                                                                 |
|   113 | CSIR-CEERI  | Development of Cold Plasma Technologies                                                                                                                                  |
|   114 | CSIR-CEERI  | Task l: High Power Sub-THz Compact Source Applicable for Security screening and Non-destructive evaluation (HP-SCAN) Task 2: Compact photonic crystal (PhC) based W-Band |
|   115 | CSIR-CSIO   | source Development of Precision Optical Coatings for Beam Manipulation in Airborne Infrared Search &Track Systems                                                        |

|   116. | CSIR- IMMT                                               | Rare earth phosphate TBCs for high temperature insulation and hot corrosion protection applications                           |
|--------|----------------------------------------------------------|-------------------------------------------------------------------------------------------------------------------------------|
|    117 | CSIR-NAL                                                 | Development of corrosion protective coatings for AA 2024 and AA 2014 by low pressure cold spray                               |
|    118 | CSIR-NAL                                                 | Development of Smart Electro-Rheological Fluid System with Hybrid Inclusions for Damping Applications                         |
|    119 | CSIR-NAL                                                 | Enhanced Flight Vision System for Civil Aircraft Simulator                                                                    |
|    120 | CSIR-NAL                                                 | Development of technologies for indigenous Wankel Rotary Combustion Engine                                                    |
|    121 | CSIR-NAL                                                 | Design and Development of Aerospace grade Autoclave for processing thermoplastic composites (HTHPAT)                          |
|    122 | CSIR-NAL                                                 | Design and analysis of structurally integrated antennas over manned and unmanned aircraft                                     |
|    123 | CSIR-NAL                                                 | High Strain Rate Characterization of Structural Materials used in a Transport Aircraft                                        |
|    124 | CSIR-NAL                                                 | Development of Micro Gas turbine Engine                                                                                       |
|    125 | CSIR- CSIO                                               | Design and Development of precision Infrared optical elements for Thermal imagining                                           |
|    126 | CSIR-CSIO                                                | Development of holographic systems for 3D dynamic displays                                                                    |
|    127 | CSIR-NAL                                                 | Experimental studies on selection of a liquid fuled and method of injection in a reverse intake valveless pulsejet engine     |
|    128 | CSIR-NAL                                                 | Multi-Sensor Data Fusion Concepts for Condition Monitoring and Diagnosis of Rotating Machinery                                |
|    129 | CSIR- NPL                                                | Realization and Dissemination of Boltzmann constant based new kelvin (K)                                                      |
|    130 | CSIR- NPL                                                | Design Development and Establishment Of Optical Interferometer Manometer: A Primary Quantum Pressure Standard at CSIR-NPL     |
|    131 | CSIR-CIMAP, CCMB, CFTRI, IIIM, IHBT, IMTECH, NBRI, NEIST | 'Deciphering the mechanism(s) of host-entophytes' oevolution, enhanced secondary metabolite production and crop productivity' |
|    132 | CSIR-, CIMAP, NBRI, IIIM, NEIST, NCL, IHBT, CFTRI, CCMB  | Genome-editing for crop improvement (GE-Crop)                                                                                 |
|    133 | CSIR-AMPRI, CIMAP, CSMCRI, IHBT, NIIST, NBRI             | Bio stimulants for stress amelioration, enhanced plant productivity and soil health                                           |
|    134 | CSIR-CCMB                                                | Towards product development in rice using mutants that have traits of agronomic importance: Phase-II                          |
|    135 | CSIR-CIMAP, NBRI                                         | Small RNAs and Associated factors for enhanced post-harvest Life (sRNA-life) Phase-II                                         |
|    136 | CSIR-NCL                                                 | Design and Development of Indigenous Strain Portfolio for the Production of Penicillin V (PenV-IP)                            |
|    137 | CSIR-CFTRI                                               | Understanding structure-function relationships in enzymes critical for                                                        |

|     |                   | the survival of bacterial food Pathogens. Phase-II                                                                                                                |
|-----|-------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 138 | CSIR-IHBT         | Exploration of Himalayan Plants for Novel Antimalarial Agents: Characterization of potential molecules (Phase-II)                                                 |
| 139 | CSIR-IMTECH       | Development of a Microbial System For the Production of Neo- Glycopeptides/ Neo-Glycoproteins For Useful Applications                                             |
| 140 | CSIR-NBRI         | Characterization and value addition of plant-based resins, gums and waxes                                                                                         |
| 141 | CSIR-NBRI         | Pathway elucidation and identification of genes involved in guggul stereos biosynthesis in Commiphora sps.                                                        |
| 142 | CSIR-NBRI         | Sub-genome dominance in end reduplication and its implication in heterotic benefits to F1-hybrids for biomass and their adaptation                                |
| 143 | CSIR-AMPRI, NBRI  | Synthesis of Zeolites from Flyash for Agriculture Applications                                                                                                    |
| 144 | CSIR-CCMB         | Apomixes and Hybrid Seed Technologies for Increasing Agricultural Production - Phase -II                                                                          |
| 145 | CSIR-CFTRI        | Non-digestible carbohydrates as functional mimics of human milk oligosaccharides                                                                                  |
| 146 | CSIR-CFTRI        | Development of chito-conjugates of spice bioactives and clove oil nano-encapsulated polymeric films for enhanced bio-functionality and anti-inflammatory activity |
| 147 | CSIR-CFTRI        | Characterization of nutraceuticals from Ulva lactuca and their utilization in functional food                                                                     |
| 148 | CSIR-CFTRI        | Development of a prototype of Machine Learning based Ripening Classifier for selected mango varieties                                                             |
| 149 | CSIR-CIMAP        | Development of Functional food: Ocimum basilicum derived line (Tukmaria) to be released as plant variety yielding 'functional food' for weight management         |
| 150 | CSIR-CIMAP        | Utilization of Ocimum Genome for production of industrially important medicinal and aromatic compounds                                                            |
| 151 | CSIR-CIMAP        | Understanding essential oil biosynthesis in commercially important aromatic grasses (Cymbopogon sp.) and Davana (Artemisia pallens) for crop improvement          |
| 152 | CSIR-CIMAP        | Induction, identification, characterization. And selection of polyploidy in Stevia rebaudiana to increase biomass, stevioside, and rebaudioside- A yield.         |
| 153 | CSIR-CIMAP, CDRI  | Metabolic engineering of Bacopa monnieri by redirecting the flux towards triterpenoid biosynthesis for enhanced bacosides production                              |
| 154 | CSIR-CLRI         | Developing a Bio- fabricated Leather                                                                                                                              |
| 155 | CSIR-CIMAP        | Development of bare-root seedling simulations system and automatic seedling transplanted for stevia                                                               |
| 156 | CSIR-CMERI, IHBT  | AI based methodology for grading machine Harvested tea leaves                                                                                                     |
| 157 | CSIR-CSMCRI       | Process development for the production of phytol and lutein from microalgae through valorization of agro-wastes.                                                  |
| 158 | CSIR-CSMCRI, CCMB | Genome sequencing of Recretohalophyte Aeluropus lagopoides (L.) trin. Ex Thw. (Poaceae)                                                                           |
| 159 | CSIR-IHBT         | Genetic improvement of high value medicinal plants                                                                                                                |
| 160 | CSIR-IHBT         | Introduction, characterization and cultivation of Ferula assa-foetida                                                                                             |

|     |                        | (Heeng) in cold desert regions of Indian Himalayas                                                                                                                                        |
|-----|------------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 161 | CSIR-IHBT              | High resolution NextGen remote sensing for medicinal, aromatic and commercially important crops                                                                                           |
| 162 | CSIR-IHBT              | "iPRESS: Integrated Plant REgulomics Software &Server"                                                                                                                                    |
| 163 | CSIR-IICB              | Classification and characterization of Phytophthora capsici effectors in understanding the early, late onset of pathogenesis and developing inhibition strategies                         |
| 164 | CSIR-IICT              | Isolation and characterization of epothilone production strain and identification of yield improvement factors                                                                            |
| 165 | CSIR-IIIM              | Understanding the physiological role of forskolin in Coleus forskohlii                                                                                                                    |
| 166 | CSIR-IIIM              | A essential oil based formulation for Post-harvest storage of fruits                                                                                                                      |
| 167 | CSIR-IIP               | The engineering/omics potential of Rhodotorulamucilagenosa IIPL32 (MTCC 25056) as a workhorse for biotechnological applications                                                           |
| 168 | CSIR-IIP               | Techno-economic evaluation, nutritional mapping, and toxicity profiling of MUFA rich yeast lipid production from biodiesel plant derived glycerin targeted to be used as edible oil blend |
| 169 | CSIR-IMMT              | Shelf-life enhancement of seeds/grains by plasma treatment (PTS)                                                                                                                          |
| 170 | CSIR-IMTECH            | Development of glycocins as 'clean label' Food Preservative                                                                                                                               |
| 171 | CSIR-IMTECH            | Iron Deficiency Anemia Solutions via Microbial Engineering Technology                                                                                                                     |
| 172 | CSIR-NBRI              | Unraveling molecular details of drought tolerance in cotton.                                                                                                                              |
| 173 | CSIR-NBRI              | Epigenetic modifications in Rhizoctoniasolani during interaction with Bacillus amyloliquefaciens and its implication for biotic stress management in rice                                 |
| 174 | CSIR-NBRI              | Regulation of pectin methylesterase inhibitor for enhancing plant- generated methanol for broad spectrum insect resistance.                                                               |
| 175 | CSIR-NBRI              | Deciphering the role of sRNAs during synergistic interaction between two Trichoderma spp                                                                                                  |
| 176 | CSIR-NBRI              | Fe and Zn bio-fortification in rice through integrated microbial and soil nitrogen management in crop field                                                                               |
| 177 | CSIR-NBRI              | Arsenic (As) risk assessment in vegetable crops in arsenic affected areas and mitigation through microbial consortia containing AsMT activity                                             |
| 178 | CSIR-NBRI, IHBT, NEIST | Conservation of threatened plant species of India                                                                                                                                         |
| 179 | CSIR-NBRI              | Plant Resource Mapping of Chambal Ravines                                                                                                                                                 |
| 180 | CSIR-NBRI              | Leveraging genetic resources for accelerated genetic improvement of grain amaranth using genomics and phenotyping approaches                                                              |
| 181 | CSIR-NBRI              | To identify the potential Aloe species for cultivation in salt affected soils                                                                                                             |
| 182 | CSIR-NBRI              | Conservation, Agronomics, Metabolomics and genomics of Indian Lotus (KAMAL)                                                                                                               |
| 183 | CSIR-NBRI              | Targeted metabolite genetics in two underutilized narcotic crops (Cannabis and Opium poppy) for Cannabinoids and Oripavine improvement                                                    |
| 184 | CSIR-NBRI              | Characterization of Boll-Weight (BW) QTL Hotspots for Cotton Yield Improvement                                                                                                            |

|   185. | CSIR-NCL                             | Developing microRNA-based strategies to control fungal plant- pathogens                                                                                 |
|--------|--------------------------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------|
|    186 | CSIR-NCL                             | Screening of elite genotypes, elucidation of biosynthetic pathway and extraction process improvisation for colchicine in Gloriosa superba               |
|    187 | CSIR-NCL                             | Gels (micro/macro) for pheromone release                                                                                                                |
|    188 | CSIR-NCL                             | Phyto-inspired peptides derived from plant protease inhibitor for crop protection                                                                       |
|    189 | CSIR-NEIST                           | Understanding the Rhizobacteria-Induced Resistance in BhutJolokia (Capsicum chinense Jacq.) against Fungal Diseases                                     |
|    190 | CSIR-NEIST                           | Edible biocatalyst for the sensory alteration of essential oils                                                                                         |
|    191 | CSIR-NIIST                           | Investigation on the separation, composition andutilization of deoiled microalgal biomass as valueadded nutraceuticals                                  |
|    192 | CSIR-NIIST                           | Food additive based on exopolysachharides (EPS) of lactic acid bacteria - Process development, structural modifications and functional characterization |
|    193 | CSIR-NIIST                           | Process development for enzymatic production of Ascorbic acid 2 glucoside                                                                               |
|    194 | CSIR-NIO, CFTRI, IMTECH, CSMCRI, IIP | Valorisation of Fishery Waste for Development of Biofertiliser, Biorefinery, Biofeed &Recovery of Biopolymers (VALBBBB)                                 |
|    195 | CSIR-CECRI                           | Tailored 2D supramolecular self-assembled architectures for investigating on-surface catalysis                                                          |
|    196 | CSIR-CECRI                           | Sustainable Electrochemical Conversion of CO2 to Methanol using Highly Selective Catalytic Electrode/GDE                                                |
|    197 | CSIR-CLRI                            | Spatial regulation of collagen orchestrated protein dynamic exposition in skin                                                                          |
|    198 | CSIR-CLRI                            | Innovative Fundamental Research for attaining Sustainability in Leather Sector                                                                          |
|    199 | CSIR-CLRI                            | Chemicals for Low Temperature Applications of Leather in Strategic sector                                                                               |
|    200 | CSIR-CSMCRI                          | Development of CO2 selective membrane and adsorbents for biogas purification and flue gas treatment                                                     |
|    201 | CSIR-CSMCRI                          | Fundamental studies on designing & synthesis of multinucleating ionophores towards high lithium loading and extraction from various sources             |
|    202 | CSIR-IICT                            | Practical Organic Synthesis Harnessing Light                                                                                                            |
|    203 | CSIR-IICT                            | Extremozymes: Studies on enzymes from extreme environments and their Industrial applications                                                            |
|    204 | CSIR-IICT                            | Stereoselective synthesis of all carbon stereocenters bearing C-CF3 bond via CF3-Pd-π-benzyl intermediate under transition metal catalysis              |
|    205 | CSIR-IICT                            | Stimulus-Driven Molecular-Motors for Asymmetric Synthesis (SDMMAS)                                                                                      |
|    206 | CSIR-IICT                            | Presenting Metallated Porous-Organic-Polymer as Next Generation Photocatalyst for Solar-Fuel Production                                                 |
|    207 | CSIR-IIP                             | Photochemical carboxylation of naphtha feed with carbon dioxide                                                                                         |
|    208 | CSIR-IICT                            | Development of PANI-Graphene Based Composites As Functional                                                                                             |

|     |            | Fillers to Conventional Coatings for Enhancement of Corrosion Inhibition Properties                        |
|-----|------------|------------------------------------------------------------------------------------------------------------|
| 209 | CSIR-IIP   | Recovery of aromatics from cracked naphtha                                                                 |
| 210 | CSIR-IIP   | Development of a Process for Catalytic Cracking of Phenolics Tar to Phenols                                |
| 211 | CSIR-IIP   | Feasibility study for the vapour phase conversion of glycerol to acrylic acid in a fixed bed reactor setup |
| 212 | CSIR-NCL   | Rheology and structural investigations of the flow of polymer functionalized particles                     |
| 213 | CSIR-NCL   | To develop scale-up guidelines for continuous flow solvent free synthesis platforms using mechanochemistry |
| 214 | CSIR-NCL   | Exploiting Frustration in Activation of N2 and CO2                                                         |
| 215 | CSIR-NIIST | Chromogenic Materials and Inks for Smart Coating and Printable Applications                                |
| 216 | CSIR-NIIST | Development of cardanol based colourless functional superhydrophobic coating                               |

## Mission Projects launched in last three years (Financial Year 2018-2021)

|   SNo. | Title of the Mission Mode Projects (MMPs)                                                                                              |
|--------|----------------------------------------------------------------------------------------------------------------------------------------|
|      1 | Sickle Cell Anaemia                                                                                                                    |
|      2 | Catalysis for Sustainable Development                                                                                                  |
|      3 | Innovative Processes and Technologies for Indian Pharmaceutical and Agrochemical Industries                                            |
|      4 | CSIR Aroma Mission                                                                                                                     |
|      5 | CSIR Phytopharmaceuticals Mission                                                                                                      |
|      6 | Development of Fast, Durable and Energy Efficient Mass Housing Scheme                                                                  |
|      7 | Technologies for Robust Structural Health Monitoring of Critical Infrastructure and Conservation &Restoration of Heritage Structures   |
|      8 | Drone based Electromagnetic and Magnetic Systems                                                                                       |
|      9 | Food and Consumer Safety Solutions                                                                                                     |
|     10 | Nutraceuticals and Nutritionals                                                                                                        |
|     11 | Nano-Biosensors and Microfluidics for Healthcare                                                                                       |
|     12 | Safety and Security of Vital Installations                                                                                             |
|     13 | Intelligent Systems (IS): Intelligent Technologies and Solutions                                                                       |
|     14 | Development of Affordable Technologies for Quality Milk Assessment                                                                     |
|     15 | Next Generation Insect Resistance in Cotton                                                                                            |
|     16 | Technological convergence for sustainable production and utilization of seaweeds                                                       |
|     17 | Commercial Deployment of Salt and Potash Technologies to Augment National Capability                                                   |
|     18 | Innovative Processes and Technologies for Agrochemicals                                                                                |
|     19 | CSIR Innovation Centre for Next Generation Energy Storage Solutions                                                                    |
|     20 | Development of Advanced Materials and Devices for Opto-electronic, Biomedical and Strategic Applications                               |
|     21 | Bulk Chemicals                                                                                                                         |
|     22 | Coal-Syngas to Methanol                                                                                                                |
|     23 | Development of Processes for Active Pharmaceutical Ingredients towards COVID 19                                                        |
|     24 | Medical Instruments &Devices                                                                                                           |
|     25 | Demonstration and validation of a 5 kW HT-PEMFC based combined cooling and power system                                                |
|     26 | Demonstration and Validation of a LT-PEMFC system for automotive application                                                           |
|     27 | Development of Dental Implants-Phase II study                                                                                          |
|     28 | Development of Innovative eco-friendly / formaldehyde free Fluorescent Pigments for vast array of water and solvent based applications |
|     29 | Developing Dental Implants for Advanced and Critical Applications                                                                      |
|     30 | Development of Novel Antistroke Phyto-pharmaceutical formulation from the roots of a Ashwagandha variety, NMITLI-118                   |

|   Ongoing NMITLI COVID-19 Projects | Ongoing NMITLI COVID-19 Projects                                                                                                              |
|------------------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------|
|                                  1 | Generation of neutralizing human monoclonal antibodies against the SARS-Cov2 virus as a threapeutic strategy to contain the COVID-19 pandemic |
|                                  2 | Development of Mycobacterium W for Covid-19: Safety and Efficacy Trial in critically ill hospitalized and at risk patients                    |
|                                  3 | Development of Ayurveda based botanical drugs for prophylazis and management of the New Corona Virus Disease (COVID-19)                       |
|                                  4 | Dev. Of an inactivated SARS-CoV2 vaccine for COVID-19 (ICoV2Vac)                                                                              |
|                                  5 | Design and Development of a portable personal Air Purifying Respiratory Device                                                                |
|                                  6 | Development of an accurate, affordable point-of care diagnostic kit for Covid-19                                                              |

|   Ongoing CSIR MLPCOVID-19 Projects | Ongoing CSIR MLPCOVID-19 Projects                                                                                                                                                                                                                                                                    |
|-------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                   1 | INtegrative GENomics of COVID-19 (INGEN-CoV2)                                                                                                                                                                                                                                                        |
|                                   2 | Development of Nanobody/mAb based ELISA for COVID19 detection                                                                                                                                                                                                                                        |
|                                   3 | Setting up of anti-Covid19 screening cell culture platform                                                                                                                                                                                                                                           |
|                                   4 | Population level based screening for COVID19 using Next Generation Sequencing (NGS)                                                                                                                                                                                                                  |
|                                   5 | Genome sequencing of SARS-CoV-2 samples from Lucknow/Uttar Pradesh                                                                                                                                                                                                                                   |
|                                   6 | Pectin-derived prebiotics as adjuvants for prophylactic treatment of COVID-19 and other similar virus diseases                                                                                                                                                                                       |
|                                   7 | Development of aptamer for recombinant SARS-CoV-2 Spike Glycoprotein-S1                                                                                                                                                                                                                              |
|                                   8 | Development of sensitive, cost effective, easy to use dipstick kit for the precise detection of COVID 19 infections                                                                                                                                                                                  |
|                                   9 | Diagnosis of COVID-19 at CSIR-IICB as part of the CSIR-Digital Surveillance Vertical                                                                                                                                                                                                                 |
|                                  10 | Development of in vitro reporter based assay system for TMPRSS2 serine protease mediated COVID-19 spike protein cleavage and screening serine protease inhibit                                                                                                                                       |
|                                  11 | An open label randomised placebo-controlled trial on passive immunization with convalescent plasma in severe covid-19 disease (picp19)                                                                                                                                                               |
|                                  12 | Evaluating SARS-CoV-2 Main protease (Mpro) inhibitors identified from the library of FDA approved drugs and novel CSIR molecules                                                                                                                                                                     |
|                                  13 | Development of a rapid Nanoparticles based immunoassay for SARS-COV-2 infection early and late phase serological diagnosis                                                                                                                                                                           |
|                                  14 | Bacteriophage recombination- and CRISPER-based combined array system and SARS-CoV2- Spike protein-based serological assay to detect COVID-19 infection                                                                                                                                               |
|                                  15 | Development of fluorescent probes, quenchers and their oligonucleotide conjugates for RT- PCR and Lateral Flow Assay based COVID-19 diagnosis                                                                                                                                                        |
|                                  16 | A High Throughput Screening Kit for COVID-19                                                                                                                                                                                                                                                         |
|                                  17 | Augmenting immunogenic response to COVID19 with recombinant BCG (AIRCOVR-BCG)                                                                                                                                                                                                                        |
|                                  18 | Serological test for COVID-19 exposure at population level                                                                                                                                                                                                                                           |
|                                  19 | Multiplexed lateral-flow device(s) for detection of COVID-19                                                                                                                                                                                                                                         |
|                                  20 | SARS-CoV-2: Sensing Sweet Spots                                                                                                                                                                                                                                                                      |
|                                  21 | Standardization of expression and purification of highly antigenic recombinant SARC-CoV2 Spike, S1, and N proteins using mammalian expression system for the downstream usage as antigens for preparation of serology-based diagnostic kit (under CSIR sub-vertical serology- based diagnostic kits) |
|                                  22 | A long-term longitudinal observational cohort study of health outcomes-Preparatory Phase                                                                                                                                                                                                             |

23. Development  of  Zinc  Gluconate  -  Vitamin  C  formulation  for  immunity  improvement  and

- management of Corona Virus Disease (COVID-19)
24. Repurposing of colchicine for management of COVID-19 patients
25. Evaluation of Candidate FDA-approved  drugs,  candidates from library of Non-toxic compounds  that  have  been  pre-clinically  cleared  and  specific  Phytopharmaceuticals  for repurposing against COVID-19 infection
26. Setting up a small molecule compound library screening platform for human serine protease TMPRSS2 and SARS-CoV2 RdRp
27. Testing for COVID-19 in wastewater as a community surveillance measure
28. Development of Drug-target based Assay platforms and screening against COVID-19
29. Clinical Trials: Phase 3, Randomized, Double-blind, comparative trial of Efficacy, Safety and Tolerability of Umifenovir and hydroxychloroquine combination therapy vs hydroxychloroquine therapy in non-severe COVID-19 patients
30. Development of proof of concept vaccine strategies for COVID-19
31. Design,  Development,  Certification  and  Commercialization  of  BiPAP  -  Non  Invasive Ventilator for COVID-19
32. CSIR Initiative on recycling of COVID-19 plastic waste from Testing Facility
33. Development of Ultrasensitive,  Rapid  and  Portable  system  for  COVID-19  Screening  using Label-free Raman Fingerprinting and AI
34. Design  and  development  of  antimicrobial  coated  3d  printable  face  shield  to  protect  from covid-19
35. Respiration Assistance Intervention Device A Portable Ventilator (Respi-AID)
36. Biosensor Development for COVID-19 Diagnosis

## Details of Lab Projects

|   Sr. No. | CSIR Lab   | Project                                                                                                                           |
|-----------|------------|-----------------------------------------------------------------------------------------------------------------------------------|
|         1 | CSIR-CEERI | Indigenous design, development & qualification of Ku band (140-210 watts) and Ka band (100-150 watts) Travelling wave tube (TWT)' |
|         2 | CSIR-NPL   | Creation and Calibration Facility for LED and LED based Lighting                                                                  |
|         3 | CSIR-URDIP | Informatics for drug-repurposing and rescue discoveries (IDrRD)                                                                   |
|         4 | CSIR-URDIP | Intellectual Property Evaluation and Commercialization (IPEC)                                                                     |
|         5 | CSIR-URDIP | Creation of E-Markets for Knowledge Products and Services                                                                         |
|         6 | CSIR-TKDL  | Modernization and upgradation of Information Technology Infrastructure of Traditional Knowledge Digital Library Unit (TKDL)       |
|         7 | CSIR-TKDL  | Digitising Traditional Indian Systems of Medicine                                                                                 |
|         8 | CSIR-NAL   | Design, Development and Certification of HANSA-NG                                                                                 |
|         9 | CSIR-NAL   | Development and Certification of 19-Seat Light Transport Aircraft (LTA)                                                           |
|        10 | CSIR-NPL   | Excellence for Ballistic Material Testing at CSIR-NPL, Delhi under Make in India Project in Body Armour                           |
|        11 | CSIR-NPL   | Production of Certified Reference Materials- Bharatiya Nirdeshak Dravya (BND)                                                     |

## Details of HARIT Projects

|   Sr. No. | CSIR Lab     | Project                                                                                                                                                                    |
|-----------|--------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|         1 | CSIR-CCMB    | Popularization of Improved Samba Mahsuri, a bacterial blight resistant and diabetic friendly rice to increase farmers' income                                              |
|         2 | CSIR-CFTRI   | Empowerment of Rural Women in Food Processing Sector through CSIR- CFTRI Intervention with Select Technologies                                                             |
|         3 | CSIR-CFTRI   | Dissemination of Nutrition, Food Safety, Food Research and Hygiene practices to general public through social media                                                        |
|         4 | CSIR-CFTRI   | Establishment of Facility Centre for Spice Processing (150-200 kg /day)                                                                                                    |
|         5 | CSIR-CLRI    | Enhancement of Economic and Social Status of Rural Populace of North- east India                                                                                           |
|         6 | CSIR-CLR1    | Social Intervention on augmenting Job opportunities & Wome Empowerment in Punjab through HRD Initiatives                                                                   |
|         7 | CSIR-CSIO    | Rural Penetration and Pilot Trials for Divya Nayan                                                                                                                         |
|         8 | CSIR- CSMCRI | Empowering coastal population by training on cultivation and harvesting value added product from economically important halophytes Salicornia brachiata and Juncus rigidus |

|   9. | CSIR- CSMCRI   | Improving quality of salt with simultaneous recovery of sodium sulphate through scientific intervention, in Nawa - Didwana region of Rajasthan                              |
|------|----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   10 | CSIR- NISTADS  | Increased crop productivity and enhanced income generation through smart micro irrigation system (More yield per Drop).                                                     |
|   11 | CSIR- NISTADS  | Intervention for herbal health and nutrition                                                                                                                                |
|   12 | CSIR- CSMCRI   | Popularizing sustainable and alternative livelihood options for low income coastal communities through imparting training on cultivation of economically important seaweeds |
|   13 | CSIR- NEERI+6  | Technologies and Products Fireworks                                                                                                                                         |

## Ongoing Projects under CSIR-Fundamental & Innovative Research in Science of Tomorrow (CSIRFIRST) Category

|   SNo | Lab          | Title                                                                                                                                    |
|-------|--------------|------------------------------------------------------------------------------------------------------------------------------------------|
|     1 | CSIR- IMTECH | Multi-temperature crystallography to probe conformational switching in FtsZ                                                              |
|     2 | CSIR-CSIO    | Development of optical multilayer mirrors with enhanced Laser Induced Damage Threshold (LIDT) for high power continuous wave fiber laser |
|     3 | CSIR-IGIB    | Increasing the protein folding arm of proteostasis using evolutionary strategies                                                         |
|     4 | CSIR-CCMB    | The origin of multiple Dicers and dsRNA Binding proteins in the RNAi initiation pathway of A. thaliana and D. melanogaster               |
|     5 | CSIR-CCMB    | Dynamic regulation of structure and function of respiratory complexes                                                                    |
|     6 | CSIR-CLRI    | Sequence Axial periodicity and exploring telo-peptide assembly in collagen: Rediscovery of biomedical treasury                           |
|     7 | CSIR-IHBT    | Characterization of reverse transcriptase (RNA dependent DNA polymerase) activity from greenhouse whitefly Trialeurodes vaporariorum     |
|     8 | CSIR-CCMB    | Mechanisitic and functional role of a 'Chiral Proofreading' variant in Animalia                                                          |
|     9 | CSIR-CGCRI   | In-situ and synergistic Magneto-Acoustic regenrative treatment (i-SMART)                                                                 |
|    10 | CSIR-CDRI    | Elucidation of neonatal cardiac regenrative potential following angoitensin II/isoproterenol mediated injury                             |
|    11 | CSIR-IGIB    | Role of unusual secondary structures in IncRNA functions                                                                                 |
|    12 | CSIR-IHBT    | Biopropecting kinetically stable lytic polysacchariede monooxygenase (s) (LPMOs) for accelerated degradation of lignocellulosic biomass  |
|    13 | CSIR-NIIST   | Engineering Next Generation Low Cost and Highly Efficient Copper Hole Conductor Based Hybrid Dye Cells for Outdoor/Indoor Photovoltaics  |
|    14 | CSIR-CSIO    | Design and Development of Augmented Reality Display for Use in Aviation Maintenance                                                      |
|    15 | CSIR-CSIO    | Design and Development of Precision Silicon Optics for Soft X-Rays by Micro-Machining process Chain                                      |
|    16 | CSIR-IHBT    | Investigating mechanisms underlying transgenerational heat stress adaptation in plants                                                   |
|    17 | CSIR- CSMCRI | Biomimetic design and application of chiral bifunctional ligands for asymmetric?- functional reactions                                   |

## Establishments of CSIR are as given below:

## Biological Sciences

- (i) CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad
- (ii) CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow
- (iii) CSIR-Central Food Technological Research Institute (CSIR-CFTRI), Mysore
- (iv) CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow
- (v) CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi
- (vi) CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur
- (vii) CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata
- (viii) CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu
- (ix) CSIR-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh
- (x) CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow
- (xi) CSIR-National Botanical Research Institute (CSIR-NBRI), Lucknow

## Chemical Sciences

- (i) CSIR-Central Leather Research Institute (CSIR-CLRI), Chennai
- (ii) CSIR-Central Electrochemical Research Institute (CSIR-CECRI), Karaikudi
- (iii) CSIR-Central Salt & Marine Chemicals Research Institute (CSIR-CSMCRI), Bhavnagar
- (iv) CSIR-Central Institute of Mining and Fuel Research (CSIR-CIMFR), Dhanbad
- (v) CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad
- (vi) CSIR-Indian Institute of Petroleum (CSIR-HP), Dehradun
- (vii) CSIR-National Chemical Laboratory (CSIR-NCL), Pune
- (viii) CSIR-North-East Institute of Science & Technology (CSIR-NEIST), Jorhat
- (ix) CSIR-National Institute of Interdisciplinary Science & Technology (CSIR-NIIST), Thiruvananthapuram

## Engineering Sciences Cluster

- (i) CSIR-Advanced Materials and Processes Research Institute (CSIR-AMPRI), Bhopal
- (ii) CSIR-Central Building Research Institute (CSIR-CBRI), Roorkee
- (iii) CSIR-Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata
- (iv) CSIR-Central Mechanical Engineering Research Institute (CSIR-CMERI), Durgapur
- (v) CSIR-Central Road Research Institute (CSIR-CRRI), New Delhi
- (vi) CSIR-Institute of Minerals and Materials Technology (CSIR-IMMT), Bhubaneshwar
- (vii) CSIR-National Aerospace Laboratories (CSIR-NAL), Bengaluru
- (viii) CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nagpur
- (ix) CSIR-National Metallurgical Laboratory (CSIR-NML), Jamshedpur
- (x) CSIR-Structural Engineering Research Centre (CSIR-SERC), Chennai

## Physical Sciences Cluster

- (i) CSIR-Central Electronics Engineering Research Institute (CSIR-CEERI), Pilani
- (ii) CSIR-Central Scientific Instruments Organization (CSIR-CSIO), Chandigarh
- (iii) CSIR-National Geophysical Research Institute (CSIR-NGRI), Hyderabad
- (iv) CSIR-National Institute of Oceanography (CSIR-NIO), Goa
- (v) CSIR-National Physical Laboratory (CSIR-NPL), New Delhi

## Information Sciences Cluster

- (i) CSIR-National Institute of Science Communication & Policy Research, New Delhi
- (ii) Fourth Paradigm Institute (CSIR-4PI), Bengaluru

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