Lok Sabha Question No. 2108 (UNSTARRED), answered on 2022-07-29
Subject: Promote Evidence based practices
Ministry: AYURVEDA,YOGA & NATUROPATHY,UNANI,SIDDHA AND HOMEOPATHY (AYUSH)
Asked by: S. Jagathrakshakan

## GOVERNMENT OF INDIA MINISTRY OF AYUSH

## LOK SABHA UNSTARRED QUESTION NO. 2108 TO BE ANSWERED ON 29.07.2022

## PROMOTE EVIDENCE BASED PRACTICES

## 2108.       SHRI S. JAGATHRAKSHAKAN ;

Will the Minister of AYUSH be pleased to state:

- (a) whether the research councils set up by the Ministry of Ayush are putting in efforts to promote evidence  based  practices  through  interdisciplinary  and  integrative  research,  enabling  its  global access;
- (b) if so, the details thereof ; and
- (c) if not, the reasons therefor ?

## ANSWER THE MINISTER OF AYUSH (SHRI SARBANANDA SONOWAL)

(DR. MAHENDRABHAI MUNJAPARA)

MUNJAPARA)

- (a) Yes,  Sir.  Five  Research  Councils  namely  Central  Council  for  Research  in  Ayurvedic  Sciences (CCRAS), Central Council for Research in Homoeopathy (CCRH), Central Council for Research in Unani Medicine (CCRUM), Central Council for Research in Siddha (CCRS) and Central Council for  Research  in  Yoga  &  Naturopathy  (CCRYN)  are  functioning  under  the  aegis  of  Ministry  of Ayush. These Councils are working on various interdisciplinary and integrative research projects with reputed Medical/Research organizations of the country to promote evidence based practices in AYUSH  systems  of  medicines.  They  are  working  in  collaboration  with  reputed  scientific organization/Medical Institutions/Universities and are engaged in multifaceted research activities in the area of AYUSH systems of medicines to promote their global access.
- (b) The  Central  Councilsunder  Ministry  of  Ayush  have  undertaken  various  collaborative  research projects  with  reputed  Institutions/Organizations  across  the  country.  Details  of  such  projects  are placed as an Annexure .
- (c) Not applicable.

*********

## Details of Collaborative Research Projects undertaken by five Research Councils of Ministry of Ayush.

## 1. Central Council for Research in Siddha (CCRS)

- a) Central  Council  for  Research  in  Siddha  (CCRS)  conducts  research  activities  in  Medicinal Plants  Research  (Medico-Ethno  Botanical  Survey,  Cultivation,  and  Pharmacognosy),  Drug Standardization,  Pharmacological  Research,  Fundamental  Research,  Clinical  Research  and Literary Research.
- b) Central  Council  for  Research  in  Siddha  (CCRS)  is  currently  involved  in  validating  Siddha drugs through clinical trials so as to integrate Siddha drug therapy with the modern system of medicine.
- c) Integrated  Siddha  cancer  OPD  is  successfully  functioning  at  All  India  Institute  of  Ayurveda campus aiding the Palliative care of cancer patients through the Siddha system.
- d) KabasuraKudineerhas been provided to all mild / asymptomatic COVID positive / patients in Allopathy medical colleges and hospitals as integrated therapy with modern medicine standard care of treatment and shown significant results published in an international journal.

CCRS has conducted the following clinical studies in collaboration with allopathy Medical Colleges and Institute

|   S. No. | Collaborating Institute/College                                                                 | TitleoftheResearchProject                                                                                                                                                                                                                    |
|----------|-------------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|        1 | Government Stanley Medical College, Chennai, Tamil Nadu                                         | A prospective, single centre, randomized open labelled comparative clinical study to evaluate the effectiveness of Siddha medicine, KabasuraKudineer and vitamin c-zinc supplementation in the management of asymptomatic COVID-19 patients. |
|        2 | Govt. Theni Medical College, Tamil Nadu                                                         | A randomized open labeled clinical study to compare the effectiveness of KabasuraKudineer and Vitamin-C Zinc supplementation in the management of asymptomatic SARS-CoV-2 patients.                                                          |
|        3 | Govt. Medical College, ESI hospital, Coimbatore, Tamil Nadu                                     | Retrospective Survival analysis to assess the length of stay of novel coronavirus (COVID-19) patients in GMC & ESIH Coimbatore who were under- Integrated Medicine - Zinc, Vitamin C & KabasuraKudineer (ZVcKK).                             |
|        4 | Govt. Institute of Medical Sciences, Greater Noida and Siddha Clinical Research Unit, New Delhi | A Double blinded RCT Namely "A Double Blinded controlled RCT to evaluate the efficacy NilavembuKudineer and KabasuraKudineer in Symptomatic COVID-19 Patients" was planned as a collaborative study.                                         |
|        5 | Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu                 | Clinical validation of the 'Immune booster' potential of the Siddha medicine drug, KabasuraKudineer (KSK) in asymptomatic contacts of COVID-19 cases: a controlled clinical trial.                                                           |
|        6 | GMC&ESIH Coimbatore                                                                             | Retrospective Survival analysis to assess the length of stay of novel coronavirus (COVID-19) patients in GMC & ESIH Coimbatore who were under- Integrated Medicine - Zinc, Vitamin C &KabasuraKudineer (ZVcKK).                              |

|   7. | National Institute of Epidemiology (ICMR), Ayyapakkam, Chennai                    |  Status of labelling, drug information and branding in marketed anti-diabetic Siddha formulations; Cross- sectional study.  Multicentric open randomized parallel phase-I B clinical trial to compare the efficacy of Siddha poly herbal decoction(NVK) with that of standard treatment protocol for reducing virus load and fever in adult dengue fever patients, Tamil Nadu.                                                                                              |
|------|-----------------------------------------------------------------------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    8 | College of Pharmacy, Sri Ramachandra University, Chennai                          |  SwasthyaRakshya programme.  Toxicity and in-vivo efficacy studies of NilavembuKudineer.  Toxicity and in-vivo efficacy studies of nunakadaguthailam.  Clinical validation of the 'Immune booster' potential of the Siddha medicine drug, KabasuraKudineer (KSK) in asymptomatic contacts of COVID-19 cases: a controlled clinical trial.                                                                                                                                 |
|    9 | Accelerating Growth of New India's Innovations (AGNII) Invest India               |  Ministry of AYUSH, Govt. of India, with active cooperation with Accelerating Growth of New India Innovation (AGNIi) had taken initiatives for the commercialization of R&D technologies and products developed by Research Councils. The following products of CCRS have been taken to commercialize through AGNIi.  Management of Type II Diabetes and related disorders.  Pharmaceutical excipient / Binder /Disintegrant.                                              |
|   10 | International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi |  Pre- clinical studies to evaluate the anti - viral effect of MAM(a Siddha Health drink) for COVID -19.                                                                                                                                                                                                                                                                                                                                                                      |
|   11 | Regional Centre for Biotechnology(RCB), Faridabad                                 |  Anti - viral activity of KabasuraKudineer.  Anti - viral activity of NilavembuKudineer.                                                                                                                                                                                                                                                                                                                                                                                    |
|   12 | SVIMS , Tirupathi                                                                 |  SIMPLE - Siddha integrative treatment protocol guidelines - Treatment protocol guidelines for integrative approach of Siddha System of medicine and Western Medicine for metabolic syndrome, to standardize the integrative treatment and research have submitted by SCRU, Tirupati and it is in pipeline. This proposal aims to establish the Siddha integrative treatment protocol guidelines for hypertension, diabetes, obesity, and metabolic syndrome.  Clinical OPD |
|   13 | Vellore Institute of Technology, Vellore                                          |  In Silico computational screening of KabasuraKudineer - Official Siddha Formulation and JACOM against SARS-CoV-2 spike protein.                                                                                                                                                                                                                                                                                                                                             |
|   14 | Pondicherry University, Puducherry                                                | An out-patient unit (co-located) of CCRS - Siddha Medical Services Unitis functioning at the Health Centre in Pondicherry University campus, Puducherry.                                                                                                                                                                                                                                                                                                                      |

|   15. | Mother Therasa Post Graduate and Research Institute of Health Sciences, Puducherry   |  In-process standardization of VelvangaParpam (VP) - a classical Siddha drug and a pilot study to evaluate its safety and therapeutic efficacy in madhumegam (type II Diabetes mellitus).                                               |
|-------|--------------------------------------------------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    16 | National Institute of Nutrition                                                      | A Collaborative IMR project entitled 'Development of health flakes (SIDKAD), a Siddha Kayakarpam diet for diabetes and evaluating its anti-oxidant and anti- inflammatory activity' is in progress with National Institute of Nutrition. |
|    17 | All India Institute of Ayurveda                                                      | A Collaborative IMR project entitled 'Clinical trial to evaluate the safety and efficacy of Siddha medicine nandhimezhugu in stage 1 and 2 breast cancer patients' is in progress.                                                       |
|    18 | Presidency college, Chennai                                                          | A project entitled 'Study of Siddha Geo pharmaceuticals - Process validation and Structural Characterization' is in progress.                                                                                                            |

## 2. Central Council for Research in Unani Medicines (CCRUM):-

Ongoing collaborative projects:

|   S.No | TitleoftheResearchProject                                                                                                                                                        | Collaborating Institute/College                                                            |
|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------------------------------------------------------------------------------------------|
|      1 | Experimental studies on the hepatoprotective and immunomodulatory effects of Dawa-Ul-Kurkum, a polyherbal Unani preparation, and its cellular and molecular mechanisms, in rats. | Dept of Pharmacology, VPCI, University of Delhi                                            |
|      2 | Evaluation of the Anticancer Potential of an Unani Pharmacopoeial Formulation, 'Dawa-Ul-Kurkum'                                                                                  | Amity Institute of Pharmacy, Amity University, Noida                                       |
|      3 | Pharmacokinetics, stability and Quality Control Studies on Araqiyat of the Unani Pharmacopoeia of India using HPTLC and GC-MS                                                    | Faculty of Pharmacy, JamiaHamdard, New Delhi                                               |
|      4 | Evaluation of Aftimoon (CuscutaReflexaRoxb.) Plant and its Seeds on Different Human Cancer (Sartan) Cell Lines                                                                   | Department of Chemistry, JamiaMilliaIslamia, New Delhi                                     |
|      5 | Delineating the anti-cancer potential and the mechanism action of Unani medicinal formulation Itrifal-e-aftimoon Chronic MyelogenousLeukemia                                     | of in Departmentof Biochemistry, All India Institute Of Medical Science (AIIMS), New Delhi |
|      6 | 'Effect of Unani preparations on macrophage polarization and its role in Increased Browning of fat leading to amelioration of insulin resistance'                                | Department of Bio Chemistry, JAMIA HAMDARD, New Delhi                                      |

## 3. Central Council for Research in Homoeopathy Sciences (CCRH)

## Fundamental research

|   Sl. No. | Title of the study                                                                                                                                                                    | Name of the collaborating organizations   | Year of Initiation   | Current Status   |
|-----------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-------------------------------------------|----------------------|------------------|
|         1 | Physicochemical studies of homoeopathic drug formulations by using volumetric, acoustic, viscometric, optical and Conductometric measurements,                                        | Dyal Singh College, New Delhi.            | Oct 2017             | Ongoing          |
|         2 | Role of Silicea in cancer regression: A mechanistic study.                                                                                                                            | Bose Institute, Kolkata                   | June 2019            | Ongoing          |
|         3 | Efficacy of Homoeopathic medicines (30C) on Propylthiouracil (PTU) induced hypothyroid rat,                                                                                           | Utkal University, Bhubaneswar             | Feb 2019             | Ongoing          |
|         4 | Deciphering the osteogenic effect of Symphytumofficinale using human bone marrow derived mesenchymal stem cells in vitro and rodent model.                                            | AIIMS, New Delhi                          | September 2019       | Ongoing          |
|         5 | Pharmacological screening of Homoeopathic drugs used in rheumatoid arthritis.                                                                                                         | AIIMS, New Delhi                          | September 2019       | Ongoing          |
|         6 | To study the impact of homeopathic medicines on key genes and proteins controlling cell proliferation and cell death in Hormone Dependent and Independent Breast and Prostate Cancer. | Amity University, Noida                   | August 2019          | Ongoing          |
|         7 | Mechanism of anti-malarial and anti-leishmanial actions of the homoeopathic formulation of nanocurcumin in a susceptible host.                                                        | KIIT University, Bhubaneswar              | September 2020       | Ongoing          |

|   8. | Investigation of the anti- neuropathic efficacy of Homeopathic Dilutions of ToxicodendronPubescens using preclinical models.        | DPSRU, Delhi                              | January 2021   | Ongoing   |
|------|-------------------------------------------------------------------------------------------------------------------------------------|-------------------------------------------|----------------|-----------|
|    9 | Effect of homoeopathic medicines on chikungunya virus (CHIKV) induced pathogenicity in suckling mice.                               | DACRRI(H), Kolkata                        | September 2019 | Ongoing   |
|   10 | Development of Japanese Encephalitis virus Nosode and to study its Efficacy in Animal Model.                                        | DACRRI(H), Kolkata                        | July 2019      | Ongoing   |
|   11 | Role of crotalushorridus and phosphorus on antibody dependent enhancement (ADE) of Dengue virus infection leading to complications. | DACRRI(H), Kolkata                        | September 2019 | Ongoing   |
|   12 | Safety Studies of Homoeopathic Drugs,                                                                                               | AIIMS, New Delhi                          | March 2022     | Ongoing   |
|   13 | Clinical Evaluation of some Homoeopathic Medicine Against Mites induced Dermatitis in Dog                                           | DUVASU, Mathura                           | January 2021   | Ongoing   |
|   14 | Identification of Homoeopathic formulations with Anti- Cervical Cancer and Anti- HPV Activity: Phase-1 in vitro Study               | University of Delhi (North Campus), Delhi | January 2021   | Ongoing   |
|   15 | Testing and measurement of Homeopathic medicine Potency using their Colligative properties.                                         | CIIRC, Bengaluru                          | March 2021     | Ongoing   |
|   16 | Potential of Homoeopathic Drugs against Neonatal Calf Diarrhoea,                                                                    | IVRI, Izatnagar, Bareilly, U.P.           | January 2021   | Ongoing   |
|   17 | Agro-Homeopathy: Potential of Homeopathic as a tool to manage stem rot pathogen complex for a sustainable agriculture.              | ANGRAU, Hyderabad, Telangana              | January 2019   | Ongoing   |

## Clinical Research

|   Sl. No. | Title of the study                                                                                                                                                                                                  | Name of the collaborating organizations                                           |   Year of Initiation | Current Status   |
|-----------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-----------------------------------------------------------------------------------|----------------------|------------------|
|         1 | Usefulness of individualized Homoeopathy versus standard allopathic treatment in acute uncomplicated Urinary Tract Infection (UTI): A randomized comparative trial.                                                 | Intramural                                                                        |                 2018 | Ongoing          |
|         2 | Effectiveness of homoeopathy in children with Intellectual Disability                                                                                                                                               | National institute for empowerment of persons with multiple disabilities, Chennai |                 2020 | ongoing          |
|         3 | Effectiveness of Homoeopathy with standard care vs Standard care alone in patients with chronic kidney disease on haemodialysis: an open label, pragmatic randomized, controlled, feasibility trial (A pilot study) | Agartala medical college and hospital Agartala, Tripura                           |                 2021 | ongoing          |
|         4 | Management of trigeminal neuralgia with homoeopathic intervention as an add-on to the standard treatment - A double blind randomized controlled trial.                                                              | Janakpuri super speciality hospital, New Delhi                                    |                 2021 | ongoing          |
|         5 | Phase II study to assess safety and efficacy of using potentized (tautopathy) form of chemotherapy at Apollo Hospital, Chennai                                                                                      | Apollo Hospital Chennai                                                           |                 2021 | ongoing          |
|         6 | An Open Label, Interventional, Prospective, Pilot Study To Evaluate Response To Individualized Homoeopathic Treatment In Case Of Oral Lichen Planus                                                                 | Cantonment General Hospital, Delhi Cantonment, New Delhi                          |                 2020 | Ongoing          |

|   Sl. No. | Title of the study                                                                                                                             | Name of the collaborating organizations                       |   Year of Initiation | Current Status   |
|-----------|------------------------------------------------------------------------------------------------------------------------------------------------|---------------------------------------------------------------|----------------------|------------------|
|         7 | Homoeopathy as adjuvant therapy to standard medical management in persons with Haemophilia (PWH)- An exploratory comparative study             | MotiwalaHomoeopathic Medical College, Nashik                  |                 2019 | Ongoing          |
|         8 | A Clinical and Molecular study to explore the effect of Homeopathy in Psoriasis                                                                | AIIMS, Bhopal, and Govt. Homoeopathic Medical College, Bhopal |                 2021 | Ongoing          |
|         9 | Knowledge and Attitude towards Ayush systems of Medicine in Chronic Kidney Disease: A cross sectional study                                    | Agartala medical college and hospital Agartala, Tripura       |                 2021 | Ongoing          |
|        10 | Managment of polycystic ovarian syndrome with homoeopathic intervention vs standard conventional treatment: A non randomized comparative study | Intramural                                                    |                 2020 | ongoing          |

## Epidemic Research

|   S.No. | Title of the Project                                                                                                     | Study Centre/ Collaborating organization   |   Year of Initiatio n | Year of Completion   | Status   |
|---------|--------------------------------------------------------------------------------------------------------------------------|--------------------------------------------|-----------------------|----------------------|----------|
|       1 | Study on the effect of homoeopathic medicines in modulating the interaction between haemoglobin and SARS- CoV-2 antigens | DACRRI(H), Kolkata                         |                  2020 |                      | Ongoing  |
|       2 | A study on the efficacy of homeopathic medicines on cytokine storm induced by SARS-CoV-2 virus proteins in cell line     | DACRRI(H), Kolkata                         |                  2020 |                      | Ongoing  |

| S.No.   | Title of the Project   | Study Centre/ Collaborating organization   | Year of Initiatio n   | Year of Completion   | Status   |
|---------|------------------------|--------------------------------------------|-----------------------|----------------------|----------|
|         | and in mice            |                                            |                       |                      |          |

## 4. Central Council for Research in Yoga and Naturopathy (CCRYN)

| TitleoftheResearchProject                                                                                                                                                                         | Collaborating Institute/College                                                                                             |
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-----------------------------------------------------------------------------------------------------------------------------|
| 1. EvaluationofeffectofsomeHathaYogicexercis esonprimaryandsecondaryhypertensionwithsp ecialreferencesto BodyImmunity                                                                             | Institute of MedicalSciences, BanarasHinduUniversity,Varanasi                                                               |
| 2. To evaluate the efficacy ofDhoutiKriya(Gastro-intestinal Dialysis) incomparison to otheryogic/traditionalmethodsofdialysis/ purification withspecial reference to cellularand humoral immunity | Deptt. of Nephrology,Institute of MedicalSciences,BanarasHinduUnive rsity, Varanasi                                         |
| 3. Role of Vipassana Meditationon attention, memory span andlearningabilitiesamongthestudentpopulati on                                                                                           | CentreofPsychosomaticandBiofeedbackMedicine, Faculty ofAyurveda,Instt. of MedicalSciences,Banaras Hindu University,Varanasi |
| 4. CoronaryAtherosclerosisreversal potential of Yoga LifeStyle Intervention                                                                                                                       | All India Institute ofMedicalSciences,NewDelhi                                                                              |
| 5. AnintegratedapproachofYoga therapy for stress relatedailments                                                                                                                                  | Vivekananda Kendra Yoga ResearchFoundation,Bangalore                                                                        |
| 6. Understanding ofNeurodynamicalcomplexitiesof meditative process from theEEGsignals                                                                                                             | NationalInstituteofMentalHealth&NeuroSciences, Bangalore                                                                    |
| A7. comparative study on Yoga,PerfectHealthandFertilitybehavioramon gYogic&Non-Yogiccouples                                                                                                       | Jeevan Rekha Parishad,Bhubaneshwar, Orissa                                                                                  |
| 8. Yoga for memory developmentamongschoolchildren                                                                                                                                                 | Atma Darshan SadhnaKendra, NewDelhi                                                                                         |
| 9. Coronaryarterydiseaseregressionthroughlifest ylechanges-                                                                                                                                       | J.WatumullGlobalHospitalandResearchCentre,Mo untAbu,DefenseInstituteofPhysiology&AlliedScie                                 |

| vegetarianism,moderateexercise,stressmanag ement through Rajyogameditation                                                           | nces(DIPAS),Delhi                                                                   |
|--------------------------------------------------------------------------------------------------------------------------------------|-------------------------------------------------------------------------------------|
| 10. EffectofYogicpracticesonthephysiological&a nti-oxidantsystems in man                                                             | DefenseInstituteofPhysiology&AlliedSciences(DI PAS), Delhi                          |
| 11. ToevaluatetheefficacyofYogatreatmentwithor withoutBio feedbackprocedures in the managementofthreedisorders                       | KaivalyaDhama,Lonavla,Pune                                                          |
| 12. Randomized Comparative trialtodeterminetheefficacyoftheYogatherapy onthepatientsofobesityascompared to the conventionaltreatment | KaivalyaDhama,Lonavla,Pune                                                          |
| 13. Yoga &Biofeedback for thetreatmentofIrritableBowelSyndrome                                                                       | All India Institute ofMedicalSciences,NewDelhi                                      |
| 14. To study the effect of YogicpracticesonsymptomatologyandPhysiol ogicalParametersinBronchial Asthma                               | Department ofRespiratoryCriticalCareand Sleep Medicine,SafdarjungHospital, NewDelhi |
| 15. Integrated Approach of YogaTherapy in the Management ofCancer                                                                    | Swami Vivekananda Yoga ResearchFoundation,Bangalore                                 |
| 16. Uni-nostril Yoga breathing &Obesity : A study of efficacyandmechanisms                                                           | Swami Vivekananda Yoga ResearchFoundation,Bangalore                                 |
| 17. To Study the efficacy of Yoga&Naturopathyinthemanagement of withdrawal ofdrugdependence                                          | Navjyoti- Delhi PoliceFoundation, Sarai Rohilla,Delhi                               |
| 18. Influence of Yoga in immunemodulation&outcomeofRheumatoid Arthritis                                                              | M.S.RamaiahMedicalTeaching Hospital,Bangalore                                       |
| 19. TheeffectofAsanasandPranayamasonNeurolo gical,Neuromuscular&Cardio- respiratoryfunctionsinHealthyHumanVolunte ers                | Jawaharlal InstituteofPost Graduate MedicalEducation &Research,Pondicherry          |
| 20. Yoga for computer relatedhealthproblems                                                                                          | Swami Vivekananda Yoga ResearchFoundation,Bangalore                                 |
| 21. Effect of breathing techniques&meditationonnormalindividuals& thosewithcancerin remission                                        | Instt. Rotary CancerHospital, AIIMS,NewDelhi                                        |
| 22. EffectofYogabasedtherapyin insomnia                                                                                              | JawaharlalInstituteofPostGraduateMedicalEducatio n&Research,Pondicherry             |
| A23. randomized controlled trialon the efficacy of Yoga in theManagementofBronchialAsthma                                            | All India Institute ofMedicalSciences, NewDelhi                                     |
| 24. Autonomicfunctiontestsinepilepsy- EffectofHathaYoga                                                                              | NIMHANS,Bangalore                                                                   |
| A25. study ofefficacy ofYogic&NaturopathicmeasuresinPsoriasisan d Eczema                                                             | ALN RaoMemorialAyurvedicMedical College, KOPPA,Karnataka                            |
| 26. The therapeutic effect of Yogaonpatientswithgeneralizedepilepticseizu res                                                        | KrishnamacharyaYogaMandiram, No. 16, Fourth CrossStreet, Ramakrishna Nagar,Chennai  |

| 27. Yogicrelaxationinthemanagementofulcerative colitis                                                                                                                                                                                          | AIIMS,NewDelhi                                                                                                  |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-----------------------------------------------------------------------------------------------------------------|
| 28. Effect of integrated approachof Yoga therapy for metastaticbreastcancerpatientsandstudyofDN Arepairmechanismsrelevanttocancer                                                                                                               | Vivekananda YogaAnusandhanSansthan,GavipuramCircle, KGNagar,Bangalore                                           |
| 29. RandomizedControltrail(RCT) of reflexology therapyand usual drug treatment in themanagementofintractableepilepsy                                                                                                                            | All India Institute ofMedicalSciences, NewDelhi -110029                                                         |
| 30. Anexploratoryanalysisofgeneticcorrelatesand effectsof Yoga on circadian rhythms,cognitive functions and socialburdeninmajormentaldisorders: schizophrenia,bipolardisorderanddepressiona ndtheircomparison with a cardiacgroup               | Dr.R.M.L.Hospital,NewDelhi                                                                                      |
| A31. Study to assess acute mentalstressinducedchangesinEEG, Cognitive behavior andNeuro- steroidsacrossthemenstrual cycle and effect ofmeditationonstressinducedchanges                                                                         | AIIMS,NewDelhi.                                                                                                 |
| 32. ARandomizedControlledTrail of Yoga to manage theadversestressreactionsatworkinhealthprofe ssionals                                                                                                                                          | SirGangaRamHospital,NewDelhi                                                                                    |
| 33. RandomizedControlTrialtoevaluatetheeffecti venessofcold and hot immersion bathson impaired glucose toleranceinpre-diabetes'                                                                                                                 | Nature Cure, Yoga,Acupuncture &Physiotherapy Hospital,NisargaTrust (R), NadigGalli,Sirsi-581401(N.K.),Karnataka |
| 34. EffectofYogicPracticesonSerum Lipid Profile &InsulinResistanceinHealthyObesesubjects                                                                                                                                                        | King George MedicalUniversity, Lucknow(U.P.)                                                                    |
| 35. EffectofYogaonSerumInterleukinlevelsinAdo lescentswith Depression                                                                                                                                                                           | All India Institute ofMedicalSciences, NewDelhi                                                                 |
| 36. NaturopathyandYogaInterventionforpost- strokeRehabilitation&QualityofLife Improvement-a controlledstudy                                                                                                                                     | YogaandNatureCureHome, KhundrakpamAwangLeikai, Imphal East, ImphalSaikulRoad, P.O. Pangei-795114,Manipur        |
| 37. EffectofYoga&Hydriaticapplicationonmigrai ne- AClinical,ElectrophysiologicalandImmunolo gicalstudy                                                                                                                                          | National Institute of Mental Health &Neurosciences(NIMHANS), Hosur Road,Bangalore-560029                        |
| 38. Comparison of cardiovascularautonomicfunctionsintwogroup sofmyocardialinfarction patients (age 30- 55years):Arandomizedtrialinvolving2groupso fpatients (1) onpharmacotherapyalone (2) onYoga&lifestyleinterventiontherapy& pharmacotherapy | VardhmanMahavirMedical College andSafdarjungHospital, NewDelhi                                                  |
| 39. EfficacyofNaturopathy&Yoga therapy as an adjuvant inthemanagementofNon-Hodgkin's Lymphoma[NHL]                                                                                                                                              | IndoAmericanCancerInstitute&ResearchCentre, Hyderabad                                                           |

## 5. Central Council for Research in Ayurvedic Sciences (CCRAS):-

The Council has undertaken various collaborative research projects with reputed institutions across the  country  such  as  AIIMS,  New  Delhi,  NIMHANS, Bangalore,  BHU,  Varanasi, Tata Memorial centre Mumbai, ILBS, Delhi, KGMU, Lucknow etc. adopting interdisciplinary approach.

Further the Council has undertaken studies to explore the feasibility of integration of Ayurveda with modern system of medicine through various research projects.

## Ongoing Collaborative Clinical Research project undertaken by CCRAS:

1.

2.

3.

4.

5.

6.

7.

8.

9.

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11.

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15.

| S. No.   | Details of the Project                                                                                                                                                                                                 |
|----------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|          | Clinical evaluation of the efficacy of 'AYUSH SS GRANULES' in exclusively breast feeding mothers with Insufficient Lactation (Stanyalpata)-A Randomized double blind placebo control Trial'                            |
|          | A comparative Clinical study of AYUSH-LND a coded ayurvedic Formulation in the Management of Asrigdara (Abnormal Utrerine Bleeding)                                                                                    |
|          | A phase II trial to study efficacy, toxicity and immunomodulatory effect of Carctol-S in high grade serous epithelial ovarian cancer at first serological relapse.                                                     |
|          | A randomized controlled trial to evaluate the efficacy of Marma Therapy in Lumbar Disc Herniation with Radiculopathy.                                                                                                  |
|          | A study of Ashwagandha administration in participants vaccinated against COVID-19 on safety, immunogenicity, and protection: A randomized, double blind, placebo controlled, multi-centric clinical trial              |
|          | Double Blind Randomized Placebo Controlled Multicentric Clinical Trial of Ayush M-3 in the management of Migraine.                                                                                                     |
|          | Multi-centric Collaborative Double Blind Study on Clinical Evaluation of AYUSH-SL in Chronic Filarial Lymphoedema in Patients Receiving Mass Drug Administration                                                       |
|          | Systems Biology approach to delineate molecular signatures of Prakriti in healthy humans                                                                                                                               |
|          | Assessment of Prakriti (Ayurvedic Body Constitution) of Patients with Cervical &Ovarian Cancers                                                                                                                        |
|          | Randomized control study to evaluate the efficacy of Ayush CCT and Rajyoga Meditation versus conventional treatment on clinical recovery and post operative outcomes following elective adult cardiothoracic surgeries |
|          | Randomized double blind placebo controlled clinical study of Ayurvedic coded drug 'AYUSH-A' in the management of Bronchial Asthma (TamakaShwasa)- A Collaborative Study                                                |
|          | Evaluation of Hepatoprotective activity of PTK as an add on therapy in the patients of Tuberculosis on ATT - A Double Blind Randomized controlled clinical study                                                       |
|          | Study the physiological basis and gut bacterial modulations induced by Virechana (Purgation therapy) in Healthy adults: A prospective longitudinal study                                                               |
|          | Prospective Double Blind randomized controlled clinical study on Ayurvedic intervention (SarpgandhaMishran) vs Amlodipine for the management of stage -I Primary Hypertension                                          |
|          | Evaluation of Ayush-GMH in the subjects of mild to moderate Nonalcoholic fatty liver disease (NAFLD)-A double blind randomized control clinical study                                                                  |

16.

17.

18.

19.

20.

21.

| Ayurveda therapeutic regimen as on Add-on to optimized conventional management of Parkinson's disease: an RCT for assessment of clinical, Cortical excitability, neuroimmune and Autonomic function parameters                       |
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| A Double-blind, Double Dummy, Randomised Controlled Study to Evaluate the Efficacy of Classical Ayurveda Management versus Methotrexate in Rheumatoid Arthritis (AMRA STUDY)                                                         |
| Evaluating the efficacy of Ayurvedic intervention as add-on to Conventional treatment and explore the interaction of Epigenetics, Neuro/gut biomarkers and Neuroimaging in pediatric ADHD (Attention Deficit Hyperactivity Disorder) |
| A pilot study to assess the effect of intranasal oil instillation (PratimarshaNasya) on nasal barrier function among healthy individuals                                                                                             |
| A Randomized controlled trial to evaluate the efficacy of multimodal Ayurveda interventions in JaanuSandhigatavata (Primary Knee Osteoarthritis)                                                                                     |
| The impact of Chyawanprash on immunogenicity when administered after COVID-19 vaccination in the health care personnel - An open-label, prospective, randomized, controlled study                                                    |

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