Lok Sabha Question No. 4091 (UNSTARRED), answered on 2023-03-24
Subject: Research in Ayurvedic Field
Ministry: AYURVEDA,YOGA & NATUROPATHY,UNANI,SIDDHA AND HOMEOPATHY (AYUSH)
Asked by: Sudarshan Bhagat

## GOVERNMENT OF INDIA MINISTRY OF AYUSH

## LOK SABHA UNSTARRED QUESTION NO. 4091 TO BE ANSWERED ON 24 TH  MARCH, 2023

## RESEARCH IN AYURVEDIC FIELD

## † 4091.  SHRI SUDARSHAN BHAGAT:

Will the Minister of AYUSH be pleased to state:

(a) whether a huge quantum of research is being done in the Ayurvedic field in the country during last five years;

- (b) if so, the details thereof; and;
- (c) if not, the reasons thereof?

## ANSWER THE MINISTER OF AYUSH (SHRI SARBANANDA SONOWAL)

- (a) & (b) Central Council for Research in Ayurvedic Sciences (CCRAS), an Autonomous Organization under Ministry of Ayush is undertaking, co-ordinating, formulating, developing and promoting research on scientific lines in Ayurvedic sciences. The activities are carried out through its 30 Institutes/Centres/Units located all over India and through collaborative studies with various Universities, Hospitals, and Institutes. The Council conducts research in the diverse areas comprising of Clinical Research, Medicinal Plant Research, Drug Standardization & Quality Control; Pharmacological  Research  and  Literary  &  Fundamental  Research  to  generate tangible  evidence.  The  Council  has  also  completed  68  clinical  research  projects during last 5 years as per Annex-I.

Institute of Teaching and Research in Ayurveda (ITRA), Jamnagar; National Institute of Ayurveda (NIA), Jaipur and All India Institute of Ayurveda, (AIIA) New Delhi offer postgraduate degree programs in different specialties of Ayurveda. These institutes  also  offer  research  degree  of  PhD.  National  Institute  of  Ayurveda  has completed 1328 research projects. 451 research projects are ongoing.

The  Ministry  of  Ayush  is  also  running/implementing  the  Central  Sector Scheme  namely  Ayurgyan  Scheme  having  two  components,  i.e.  (i)  Capacity Building  &  Continuing  Medical  Education  (CME)  in  Ayush  (ii)  Research  & Innovation  in  AYUSH  from  the  FY  2021-22.  The  main  aim  of  the  Ayurgyan Scheme is to support Research & Innovation in Ayush by Extra Mural Research and  Education  by  providing  academic  activities,  training,  Capacity  Building etc. The scheme is being implemented throughout the country. Under the Scheme, financial  assistance  is  provided  to  the  Organizations/  Institutions  for  research studies as per the provisions contained in the scheme guidelines, for promotion of Ayush research and to support research & Innovation in Ayush. 85 projects have been  sanctioned  under  the  scheme  from  the  FY.  2018-19  to  2022-23  (so  far). Details are at Annex-II.

The  Ministry  is  also  funding  the  projects  under  Centre  of  Excellence component  of  Ayurswasthya  Yojana  for  research  activities  on  Ayurveda.  13 projects have been sanctioned from the FY. year 2020-21 to FY. 2022-23 (so far). Details are at Annex -III

(c) Does not arise.

****

## Completed Clinical projects from 2017-18 to 2021-22

1. Clinical  evaluation  of  Parthadyarishtha  (Arjunaristha)  and  Sarpagandha  Vati  in  the management of Essential Hypertension (Uccha Raktachaap)
2. Clinical  evaluation  of  Rudraksha  Churna  in  the  management  of Essential  Hypertension (Uccha Raktachaapa)
3. Clinical evaluation of Vyoshadi Guggulu and Panchasama Churna in Amavata (Rheumatoid Arthritis)
4. Clinical Evaluation of the Efficacy and Safety of Mamajjaka Ghanavati in Madhumeha (Type 2-Diabetes)
5. Clinical Evaluation of Shirodhara with Amalaki Kwath in the Patients of Anxiety Neurosis
6. Comparative  Observation  on  changes  in  Serum  Lipid  Profile  in  patients  undergoing Snehana with pure Ghee in one group and Mahatiktak ghrita in other group
7. Effect of Sankara Sweda with Kolakulatthadi Churna heated in Dhanyamla, Simhanada Guggulu with  Rasna Saptak Kashaya in Rheumatoid Arthritis wrt pain and stiffness
8. Evaluation  of  the  Effect  of    Upanaha  treatment  with  Vachadi  upanaha  churna  in Osteoarthritis (OA Knee) wrt pain and stiffness of joints (RFD)
9. Evaluation of the effect of Jambeera Pinda Sweda in Cervical Spondylosis w.r.t. Clinical Symptomatology
10. Evaluation of changes in serum electrolyte level (na, k etc.) after Virechan karma with Erandataila
11. Clinical evaluation of efficacy of Panchtiktaguggulu Ghrita and Brihanmarichadya Taila in the management of Psoriasis w. s. r. to Pathya-apathya
12. Clinical evaluation of Goksura churna and Sveta parpati in the Management of Mutrasmari (Urolithiasis)
13. Clinical evaluation of efficacy of Khadirarishta and  Kanchanara guggulu in the management of Uterine Fibroid - An exploratory study
14. Clinical evaluation of Punarnava Guggulu and Rasna Saptaka Kashaya in the management of Rheumatoid Arthritis (Amavata)
15. A Clinical evaluation of Triphala Guggulu and Kasisadi Taila in the management of Arsha (Haemorrhoids)
16. Therapeutic evaluation of Rasnadi Gutika and Chandrakala lepa in Janusandhigata vata (Osteoarthritis)
17. Clinical evaluation of Kaishore Guggulu and Madhusnuhi Rasayana  in the management of Gout (Vatarakta)
18. Clinical evaluation of Abhadya Churna and Muktashukti Bhasma in the management of Osteopenia / Osteoporosis (Asthikshaya)
19. Clinical evaluation of Laksha Guggulu and Muktashukti  Bhasma in the management of Osteopenia/Osteoporosis
20. Clinical Evaluation of Certain Ayurvedic Formulations In The Management of Sthoulya (Obesity)
21. Clinical  evaluation  of  Mandura  vataka    in  the  management  of  Pandu    (Iron  deficiency Anaemia)
22. Clinical evaluation of Sukumara Ghritam and Brahmi churnam in the   management of Menopausal syndrome
23. Clinical evaluation of Kalyanak Ghrita in the management of Cognitive Deficit        (Smriti Daurbalya)
24. Clinical evaluation of the efficacy of Trayodashanga Guggulu, Maharasnadi Kwatha and Prasarani Taila in the management of Gridhrasi (Sciatica)
25. Clinical  Evaluation  of  Rasnadi  Kvatha  churna  (Maha),  Trayodashanga  Guggulu  and Brihatsaindhavadya  Taila  in  the  Management  of  Osteoarthritis  of  Knee  (Janugata Sandhivata)
26. Assessment of therapeutic efficacy and safety of Sitopaladi Churna  with Madhu in the management of Kasa (Stable Chronic Bronchitis)
27. Clinical  efficacy  of  Talisadi  Churna  in  the  management  of  Kasa  (Stable  Chronic Bronchitis)
28. Clinical evaluation of Haridrakhand and Triphala Kwath in the management of chronic Allergic Conjunctivitis (Kaphaja Abhishyanda)
29. A Pilot Evaluation of Safety and Efficacy of an Ayurvedic Formulation (AYUSH-64) for accelerating the recovery in cases of Influenza like Illness.
30. Clinical evaluation of Panchamrit Lauha Guggulu  and Panchgunataila in the management of Cervical Spondylosis (Greevagraha)
31. Clinical Evaluation of Ayurvedic formulations in the management of Parikartika (Fissure in Ano)
32. Clinical  Evaluation  of  Kantakaryavaleha  and  Eladi  Gutika  in  the  Management  of  Mild Stable Bronchial Asthma (Tamaka Shwasa)
33. Clinical  evaluation  of  AYUSH-PE  eye  drops  in  the  management  of  Acute  Allergic Conjunctivitis.
34. Clinical evaluation of an Ayurvedic formulation in the management of Allergic Rhinitis-a pilot study
35. Clinical evaluation of Sapthasaram Kashayam & Saraswatharishtam in the management of Primary Dysmenorrheoa- An Exploratory study
36. Clinical Evaluation of  Efficacy of Indukanta Ghrita and Trayodashang Guggulu in the Management of Rheumatoid Arthritis vis -a-vis Amavata
37. Clinical Evaluation of Eladi Churna and Draksharishta in the management of Kasa (Stable Chronic Bronchitis)
38. Clinical  evaluation  of  the  efficacy  of  Pushyanug  Churna  in  the  management  of  Sweta Pradara w.r.t. Bacterial Vaginosis (Leucorrhoea)
39. Clinical Study on Efficacy and Safety of an Ayurvedic Formulation Kutajavleha in the management of Grahani Roga
40. Clinical  evaluation  of  Svadamshtradi  Kashaya  and  Hajarulayahuda  Bhasma  in  the Management of Mutrashmari (Urolithiasis)
41. Clinical evaluation of Drakshasava in the management of Pandu (Iron Deficiency Anaemia)
42. Clinical evaluation of Shadbindu Taila Nasya and Chitraka Haritaki in the management of Pinasa (Chronic Rhinosinusitis)
43. Clinical  evaluation  of  Pathyadi  Kwatha  and  Anu  Taila  Nasya  in  the  management  of Ardhavabhedaka (Migraine).
44. Clinical  evaluation  of  the  efficacy  of  Pushyanuga  Churna  and  Usheerasava  in  the management of Abnormal Uterine Bleeding.
45. Clinical  evaluation  of  Jatiphaladya  Churna  &  Chitrakadi  Gutika  in  the  management  of Grahani
46. Clinical evaluation of Panchatikta Ghrita and Gandhakadya Malahara in the management of Vicharchika (Eczema)
47. Clinical Evaluation of Chitraka Haritaki and Lavangadi Vati in the management of Kaphaj Kasa (Stable Chronic Bronchitis)
48. Clinical  evaluation  of  Agashtya  Haritaki  Rasayana  and  Apamarga  Kshara  in  the management of Mild Stable Bronchial Asthma (Tamaka Shwasa)
49. Clinical efficacy of Kaishore Guggulu and Balaguduchyadi Taila in the management of Gout (Vatarakta)
50. Clinical evaluation of the efficacy of Soubhaya Shunthi Paka and Dashmularishta in Sutika Paricharya (Post Natal Care)
51. Clinical  evaluation  of  Drakshavaleha  in  the  management  of  Pandu  (Iron  Deficiency Anaemia)
52. Clinical evaluation of Shatavari Guda and Ashokarishta in the management of Asrigdara (Abnormal Uterine Bleeding)
53. A Prospective open labelled observational study to document the potential safety issues and prescription trends in Selected Rasausadhi's in CCRAS -OPD'S across India.
54. Clinical Evaluation of Shirodhara with Amalaki Kwath in the Patients of Anxiety Neurosis
55. Comparative  Observation  on  changes  in  Serum  Lipid  Profile  in  patients  undergoing Snehana with pure Ghee in one group and Mahatiktak ghrita in other group
56. Effect of Sankara Sweda with Kolakulatthadi Churna heated in Dhanyamla, Simhanada Guggulu with  Rasna Saptak Kashaya in Rheumatoid Arthritis wrt pain and stiffness
57. Evaluation  of  the  Effect  of    Upanaha  treatment  with  Vachadi  upanaha  churna  in Osteoarthritis (OA Knee) wrt pain and stiffness of joints (RFD)
58. Evaluation of the effect of Jambeera Pinda Sweda in Cervical Spondylosis w.r.t. Clinical Symptomatology
59. Evaluation of changes in serum electrolyte level (na, k etc.) after Virechan karma with Erandataila
60. Observation on Fistula cutting Time with Ksharsutra used in routine patients of Anorectal Fistula (Bhagandara)

## Clinical Collaborative projects during last five year

1. Clinical study of 'AYUSH Rasayana A & B' in Elderly subjects with AIIMS, New Delhi & BHU, Varanasi;
2. Development of Bio-medical instrumentation for Ksharasutra chamber for preparation of standardized Ksharasutra with IIT, New Delhi
3. Validation of Prakriti Assessment Questionnaire/Scale with reputed organizations have been completed
4. A Randomized Placebo Controlled Prospective Phase II Clinical Study of an Ayurvedic Coded Drug 'AYUSH-D' on Glycemic control in Pre-Diabetic Subjects
5. A Randomized Placebo Controlled Phase II Clinical Study of an Ayurvedic Coded Drug 'AYUSH-D' in the management of Type 2 Diabetes Mellitus as add on Therapy to Metformin
6. Multi-centric Collaborative Double Blind study on clinical evaluation of AYUSH-SL in chronic Filarial Lymphoedema in patients receiving mass drug administration
7. Controlled Clinical Trial to assess the effectiveness of topical application of C1 herbal oil on superficial external wound and spilt thickness skin graft donor's site for surgical wound healing
8. Evaluation of Add on Efficacy & Safety of an Ayurvedic coded Formulation in the management of Dengue Fever & Prevention of  its  complications  -A  Double  Blind Clinical Study

Annex-II Ayurveda Research projects under erstwhile EMR scheme in Financial Year 2018-19

|   Sl. No. | Title of the project                                                                                                                                                                                                                                         |
|-----------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|         1 | 'Potential anti-oxidant effect of selected Ayurvedic herbs in Parkinson and Alzheimer disease'                                                                                                                                                               |
|         2 | 'Validation of safety, Efficacy and Quality and Preparation of Drug Master File of Classical Ayurvedic Formulation Vasaguduchyadi Kashayam and Katakakhadioradi kashyam'                                                                                     |
|         3 | 'Cytotoxic, antitumor and anti-angiogenesis evaluation of Cow Urine (Go-mutra) based medicinal plant extract against Ehrlich ascites cells bearing mouse'                                                                                                    |
|         4 | 'The neuroprotective effect of herbal extracts derived from Allium cepa in mouse of retinal ganglion cells (RGC) damage'                                                                                                                                     |
|         5 | 'An experimental approach towards Bone marrow and microenvironment in Leukemia by using Ashwagandha (withania somifera) and Bhringaraj (Eclipta alba): Two candidate inhibitors of Hedgehog and NF-kB pathways'                                              |
|         6 | 'A Randomized Controlled Trial to assess the efficacy of Gut Therapy (Koshta Chikitsa) for managing Dysbiosis in children with Autism'                                                                                                                       |
|         7 | 'Evaluation of Novel Pharmacological Agents in Arjuna and Tulsi in Experimental Pulmonary Artery Hypertension in Rats'                                                                                                                                       |
|         8 | 'Antimicrobial Efficacy and Mechanisms of Herbal Extracts Fractions (Traditional Herbal Tooth Powder Formula) on Biofilm Forming Cariogenic Microorganisms'                                                                                                  |
|         9 | 'Prospective parallel group open label study to assess the changes in clinic- pathological variables in patients of Diabetic Nephropathy stage III receiving Ayurvedic Treatment Regimen (ATR) versus those not receiving Ayurvedic Treatment Regimen (ATR)' |
|        10 | 'A Randomized Open Label Controlled Prospective Phase II Clinical Study of HaridraChurna on Glycemic control in Pre-diabetic subjects'                                                                                                                       |
|        11 | The neuroprotective effect of herbal extracts derived from Allium cepa in mouse of retinal ganglion cells (RGC) damage'                                                                                                                                      |
|        12 | 'Evaluation of Role of Withania somnifera and Celastras puniculatus in Animal Models of Alcohol Addiction'                                                                                                                                                   |
|        13 | 'Anti-migratory role of black seed extract (thymoquinone) nanoparticle in triple negative breast cancer cells: Evaluation of Molecular mechanisms via miRNA axis'                                                                                            |
|        14 | 'Preclinical studies on Triphala for its Possible effects in treatment of Microvascular complications of Diabetes'                                                                                                                                           |
|        15 | 'To study the antitumour potential of Pashaanbhela, Punarnava, Gokshura, and Badra on the human urothelial cell carcinoma (UCC) cell lines'                                                                                                                  |
|        16 | 'Effect of Classical Ayurvedic management in PCOS'                                                                                                                                                                                                           |
|        17 | 'Effect of Indian Almond and sweet almond in diabetes induced nephropathy and cataract in rats'                                                                                                                                                              |
|        18 | 'Evaluation of Antiviral Activity of Medicinal Plant Extracts Against Influenza A Virus'                                                                                                                                                                     |

Ayurveda Research projects under erstwhile EMR scheme in Financial Year 2019-20

|   Sl. No. | Title of the project                                                                                                                                                                                            |
|-----------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|         1 | 'Evaluation of the effect of Triphala and Trimad for their effect on adipocyte biology and lipid metabolism'                                                                                                    |
|         2 | 'Evaluation of radio protective potential of medicinally important Indian bamboo plants in cancer'                                                                                                              |
|         3 | 'Evaluation of Ashtangahridayokta Brihatyadigana for their efficacy in preclinical model of Acute Renal Failure in Rats''                                                                                       |
|         4 | 'Toxicity evaluation of Ayurvedic herbo-metallic preparations'                                                                                                                                                  |
|         5 | 'An experimental approach towards Bone marrow and microenvironment in Leukemia by using Ashwagandha (Withania somifera) and Bhringaraj (Eclipta alba): Two candidate inhibitors of Hedgehog and NF-kB pathways' |
|         6 | 'Search for novel Anti-cataract agents: phytochemical and pharmacological investigation of unexplored medicinal plants of Chhattisgarh state'                                                                   |
|         7 | 'Effect of Ayurveda Nootropics on Cognitive Function in breast cancer patients on adjuvant chemotherapy: A randomized controlled trial'                                                                         |
|         8 | 'Evaluation of the heavy metals content in market samples of plant raw drugs used in Ayurveda'                                                                                                                  |
|         9 | 'Safety Evaluation of two Important Herbo-Mineral Formualtions (Gandhaka Rasayana and MahavatVidhwansan Rasa) used in Ayurvedic practice'                                                                       |
|        10 | 'Effect of oral administration of Kalyankaghritamin pediatric spastic cerebral palsy'                                                                                                                           |
|        11 | Experimental and Clinical Studies on Nagapheny (Opuntia elatior mill) an anukta dravya (extra pharmocopial drug with special reference to its haematinic activity                                               |
|        12 | Evaluation of 'Trifala' as an anti-diabetic drug in human type II diabetes mellitus and diabetic complications                                                                                                  |
|        13 | Cytotoxic, antitumor and anti-angiogenesis evaluation of Cow urine (Go-mutra) based medicinal plant extract against Ehrlich ascites cells bearing mouse                                                         |
|        14 | Evaluation of Antiviral Activity of Medicinal Plant Extracts Against Influenza A Virus                                                                                                                          |
|        15 | An Experimental & Clinical studies to evaluate the Anti-osteoporotic effect of Panchtikta Ghrita                                                                                                                |

## Ayurveda Research projects under erstwhile EMR scheme in Financial Year 2020-21

|   Sl. No. | Title of the project                                                                                                                                                                                                                                       |
|-----------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|         1 | Evaluation of radio protective potential of medicinally important Indian bamboo plants in cancer                                                                                                                                                           |
|         2 | Anti-migratory role of black seed extract (thymoquinone) nanoparticle in triple negative breast cancer (TNBC) cells: Evaluation of Molecular mechanism via miRNA axis                                                                                      |
|         3 | Prospective parallel group open label study to assess the changes in clinic- pathological variables in patients of Diabetic Nephropathy stage III receiving Ayurvedic Treatment Regimen (ATR) versus those not receiving Ayurvedic Treatment Regimen (ATR) |
|         4 | A Randomized Open Label Controlled Prospective Phase II Clinical Study of HaridraChurna on Glycemic control in Pre-diabetic subjects                                                                                                                       |

|   5 | Potential anti-oxidant effect of selected Ayurvedic herbs in Parkinson and Alzheimer disease                                                                                                                   |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   6 | An Experimental &Clinical studies to evaluate the Anti-osteoporotic effect of Panchtikta Ghrita                                                                                                                |
|   7 | The mechanism of Action of Certain Ayurvedic Medicinal Plants on Alzheimer's by Dipeptidyl Peptidase-4 Inhibition Using Herbs                                                                                  |
|   8 | Evaluation of the effect of Patrapottali sveda and Thailadhara externally and Panchatiktaka Ksheera and ghruta internally in the management of Sandhivata (Osteo arthritis-knee)'                              |
|   9 | Preclinical Studies on Triphala for its Possible Effects in Treatment of Microvascular Complications of Diabetes                                                                                               |
|  10 | Immuno-modulatory effects, protease inhibitory activity and spectroscopic characterization of select ayurvedic prophylactics and formulations: In vitro studies for novel SARS CoV infections                  |
|  11 | To study the antitumour potential of Pashaanbhela, Punarnava, Gokshura, and Badra on the human urothelial cell carcinoma (UCC) cell lines                                                                      |
|  12 | Toxicity evaluation of Ayurvedic herbo-metallic preparations                                                                                                                                                   |
|  13 | Evaluation of the heavy metals content in market samples of plant raw drugs used in Ayurveda                                                                                                                   |
|  14 | Development and validation of fermentation based immune-modulatory AYUSH kwath formulation                                                                                                                     |
|  15 | Evaluation of the heavy metals content in market samples of plant raw drugs used in Ayurveda                                                                                                                   |
|  16 | Experimental and clinical studies on Nagapheni (Opuntiaelatior Mill.) an anuktadravya (extra-pharmacological drug), with special reference to its Haematinic activity                                          |
|  17 | A retrospective review of COVID-19 related clinical outcomes following the introduction of the National Clinical Management Protocol (NCMP) on Ayurveda and Yoga and other Ayurveda interventions for COVID-19 |

## Ayurveda Research projects under erstwhile EMR scheme in Financial Year 2020-21 (Covid projects)

|   S.No. | Title of the project                                                                                                                                                           |
|---------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|       1 | Evaluation of Immuno-Modulatory Potential of Selected Ayurvedic Formulations in High Risk Quarantined Subjects and Frontline Healthcare Workers in Covid-19 Care Centre        |
|       2 | An Open-labelled black box clinical study to investigate efficacy of add on personalized Ayurveda intervention in comparison to stand alone treatment based on ICMR guidelines |
|       3 | To evaluate the efficacy of Mahasudarshan Ghan Vati and Vyaghradi Kwath in the management of patients with Covid-19 A pilot study                                              |
|       4 | Pre-Clinical efficacy (Immune modulatory) and Safety (Regulatory Toxicology) evaluation of AYUSH formulation 'AyushKwath'                                                      |

|   5 | Clinical trial to evaluate prophylactic action of Twakadi Herbal Tea in Police professionals working in Covid-19 pandemic                                                                                                     |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   6 | Effect of Malla Chandrodaya &Ashtadashangghan vati in Patients with mild to moderate Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections: A Propective Observational Study                                       |
|   7 | Randomized comparative clinical trial to assess the efficacy of Pippali Rasayana and Nagaradi Kashaya Ghana Vati combination as an adjuvant tratment with ICMR directed therapy in Covid-19 positive mildly symptomatic cases |
|   8 | An Open-labelled black box clinical study to investigate efficacy of add on personalized Ayurveda intervention in comparison to stand alone treatment based n ICMR guidelines                                                 |
|   9 | Pre-Exposure, Ayurveda Prophylaxis for SARS-Coronavirus-2 in Healthcare Workers: A Pragmatic, Risk Stratified, Randomized Clinical Trial                                                                                      |
|  10 | Study of Swarna Amalaki as an Immunomodulatory in COVID 19 patients                                                                                                                                                           |
|  11 | "An interventional, single arm study to observe and assess the effectiveness of 'Vyaghradi Kashaya Tab' in preventing the progression of severity in asymptomatic, mild to moderate COVID-19 cases                            |
|  12 | A Trial of Shirashadi Kasai in Adults Hospitalized with Moderate to Severe Covid-19                                                                                                                                           |
|  13 | A Clinical Evaluation of Efficacy of Ayurvedic treatment regimen as an Add-on therapy with Modern Medicine in COVID-19 A Randomized, Multi-centre, single Blind, Prospective Clinical Study                                   |
|  14 | A single arm prospective study to evaluate the efficacy and safety of Shatyadi Kashaya and Vasavaleha combination to combat the progression of asymptomatic and mild to moderate cases of Covid-19 in to severe category      |

## Ayurveda Research projects under erstwhile EMR scheme in Financial Year 2021-22

|   Sl. No. | Title of the project                                                                                                                                                                                            |
|-----------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|         1 | Evaluation of AshtangahridayoktaBrihatyadigana for their efficacy in preclinical model of Acute Renal Failure in Rats'                                                                                          |
|         2 | Clinical effect of Ayurvedic Formulation (Withania somnifera, Tinospora cordifolia, Moringa oleifera, Adhatoda vasica, Piper longum, Glycyrrhiza glabra, Ocimum sanctum and Curcuma longa) in COVID-19 patients |
|         3 | Antimicrobial Efficacy and Mechanisms of Herbal Extracts Fractions (Traditional Herbal Tooth Powder Formula) on Biofilm Forming Cariogenic Microorganisms                                                       |
|         4 | Repurposing of Classical Ayurvedic Formulations For Their Anti-Viral Effects on SARS Cov-2 Protease: A Pre-clinical In Vitro Screening Approach                                                                 |
|         5 | Effect of Ayurveda Nootropics on Cognitive Function in breast cancer patients on adjuvant chemotherapy: A randomized controlled trial                                                                           |

- 6 An open label controlled clinical study to evaluate the efficacyof - Sudarshana churna, Yastimadhu  churna  and  Amritharista  as  add  on  therapy  to  standard  care  in  Mild symptomatic positive COVID-19 patients.

## Ayurveda Research projects under Research and Innovation in AYUSH component in Financial Year 2021-22

|   Sl. No. | Title of the project                                                                                                                                                                                                                                      |
|-----------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|         1 | Pre-Clinical efficacy (immune modulatory) and salary (Regulatory Toxicology) evaluation of Ayush formulation 'AyushKwath                                                                                                                                  |
|         2 | Prospective parallel group open label study to assess the changes in clinic-pathological variables in patients of Diabetic Nephropathy stage III receiving Ayurvedic Treatment Regimen (ATR) versus those not receiving Ayurvedic Treatment Regimen (ATR) |
|         3 | A Randomized Open Label Controlled Prospective Phase II Clinical Study of HaridraChurna on Glycemic control in Pre-diabetic subjects                                                                                                                      |
|         4 | A Randomized Controlled Trial to assess the efficacy of Gut Therapy (Koshta Chikitsa) for managing Dysbiosis in children with Autism                                                                                                                      |
|         5 | Clinical Evaluation of Ayurveda based Integrative Management of Diabetic Retinopathy                                                                                                                                                                      |
|         6 | An experimental approach towards Bone marrow and microenvironment in Leukemia by using Ashwagandha (Withania somifera) and Bhringaraj (Eclipta alba): Two candidate inhibitors of Hedgehog and NF-kB pathways                                             |
|         7 | Evaluation of Role of Withania somnifera and Celastras paniculatus in Animal Models of Alcohol Addiction                                                                                                                                                  |
|         8 | Evaluation of the effect of Triphala and Trimad for their effect on adipocyte biology and lipid metabolism                                                                                                                                                |
|         9 | Preclinical Studies on Triphala for its Possible Effects in Treatment of Microvascular Complications of Diabetes                                                                                                                                          |

## Ayurveda Research projects under Research and Innovation in AYUSH component in Financial Year 2022-23

|   Sl. No. | Title of the project                                                                                                                                                  |
|-----------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|         1 | Effect of Classical Ayurvedic management in PCOS                                                                                                                      |
|         2 | Experimental and clinical studies on Nagapheni (Opuntiaelatior Mill.) an anuktadravya (extra-pharmacological drug), with special reference to its Haematinic activity |
|         3 | Toxicity evaluation of Ayurvedicherbo-metallic preparations                                                                                                           |
|         4 | Randomized Controlled Trial on effect of Indigenous Cows Ghrita and Jatyadi Ghrita on wound healing                                                                   |
|         5 | Effect of oral administration of Kalyankaghritam in pediatric spastic cerebral palsy                                                                                  |
|         6 | Effect of ghee from indigenous cow milk on cognition and neuro-protection against Alzheimer's disease                                                                 |

## List of projects under CoE component of Ayurswasthya Yojana for research activities on Ayurveda

| S.No.          | Name of the organisation                                                                                                            | Name of the project                                                                                                                                                                                                               |
|----------------|-------------------------------------------------------------------------------------------------------------------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| FY - 2020-2021 | FY - 2020-2021                                                                                                                      | FY - 2020-2021                                                                                                                                                                                                                    |
| 1.             | Institute of Teaching and Research in Ayurveda (ITRA), Jamnagar (previous name Gujarat Ayurved University)                          | Center of Excellence in Gastrointestinal disorders                                                                                                                                                                                |
| 2.             | Interdisciplinary School of Health Sciences, Pune                                                                                   | Pre-clinical study on development of therapeutic adjuvants based on Ayurveda                                                                                                                                                      |
| 3.             | CIMR, AIIMS, New Delhi                                                                                                              | Centre of Excellence for Yoga &Ayurveda                                                                                                                                                                                           |
| 4.             | Central Ayurveda Research Institute, Bengaluru (Formerly Regional Research Institute for Metabolic Disorders), Jayanagar, Bengaluru | Centre of excellence in Research and Clinical services for Madhumeha (Diabetes mellitus)                                                                                                                                          |
| 5.             | CSIR- Institute of Genomics & Integrative Biology (IGIB)                                                                            | Centre of excellence for Applied Development of Ayurveda Prakriti and Genomics                                                                                                                                                    |
| FY 2021-22     | FY 2021-22                                                                                                                          | FY 2021-22                                                                                                                                                                                                                        |
| 1.             | Indian Institute of Technology, Jodhpur                                                                                             | Centre of Excellence in AYURTech for Integrative Precision Health and Medicine.                                                                                                                                                   |
| 2.             | Institute of Liver and Biliary Sciences (ILBS), New Delhi                                                                           | Effects of Indian Foods and Ayurvedic drugs on healthy and diseased Liver.                                                                                                                                                        |
| 3.             | Arya Vaidya Sala (AVS), Kottakkal, Malappuram, Kerala                                                                               | Setting up CoE in Cancer Research - Arya Vaidya Sala, Kottakkal.                                                                                                                                                                  |
| 4.             | Banaras Hindu University                                                                                                            | For establishing National Resource Centre on Ksharsutra Therapy, Department of Shalya Tantra, Institute of Medical Sciences / National Referral Centre for Teaching, Research, Training and referral patients care on Ksharsutra. |
| FY 2022-23     | FY 2022-23                                                                                                                          | FY 2022-23                                                                                                                                                                                                                        |
| 1.             | CIMR, AIIMS, New Delhi                                                                                                              | Centre of Excellence for Yoga &Ayurveda                                                                                                                                                                                           |
| 2.             | National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore                                                          | Centre of Excellence in AYUSH Research under Ayurswasthya Yojana.                                                                                                                                                                 |

|   3. | Central Ayurveda Research Institute, Bengaluru (Formerly Regional Research Institute for Metabolic Disorders), Jayanagar, Bengaluru   | Centre of excellence in Research and Clinical services for Madhumeha (Diabetes mellitus)   |
|------|---------------------------------------------------------------------------------------------------------------------------------------|--------------------------------------------------------------------------------------------|
|    4 | Institute of Liver and Biliary Sciences (ILBS), New Delhi                                                                             | Effects of Indian Foods and Ayurvedic drugs on healthy and diseased Liver.                 |

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