Lok Sabha Question No. 2505 (UNSTARRED), answered on 2018-12-26
Subject: Production of Radio Isotope
Ministry: ATOMIC ENERGY
Asked by: NARANBHAI KACHHADIA, BIDYUT BARAN MAHATO, SUMEDHANAND SARASWATI, CHANDRA PRAKASH JOSHI

## GOVERNMENT OF INDIA DEPARTMENT OF ATOMIC ENERGY

## LOK SABHA UNSTARRED QUESTION NO. 2505

TO BE ANSWERED ON 26.12.2018

## PRODUCTION OF RADIO ISOTOPE

## 2505. SHRI NARANBHAI KACHHADIYA:

SHRI BIDYUT BARAN MAHATO: SHRI SUMEDHANAND SARSWATI: SHRI CHANDRA PRAKASH JOSHI:

Will the PRIME MINISTER be pleased to state:

- (a) whether Cyclotron is used for production of radio isotope used for diagnostic and  medical  use  in  cancer  and  if  so,  the  types  of  cancer  in  these  radio isotopes are used;
- (b) whether  cyclotron-30,  the  largest  cyclotron  for  medical  use  in  the  country became operational this year; and
- (c) if so, the cost of its research and manufacturing?

## ANSWER

THE  MINISTER  OF  STATE  FOR  PERSONNEL,  PUBLIC  GRIEVANCES  & PENSIONS AND PRIME MINISTER'S OFFICE (Dr. JITENDRA SINGH):

- (a) Yes,  Sir.  The  radio-isotopes  such  as  FDG  ( 18 F),  Gallium  ( 67 Ga),  Thallium ( 201 Tl),  Palladium  ( 103 Pd),  Iodine  ( 123 I)  are  used  for  preparation  of  various radiopharmaceuticals,  which  are  used for  diagnostics  and  cancer  therapy, as detailed below:-
- i) 18 F  tracers for various diagnostic purposes

| Radiopharmaceuticals         | Usages                                     |
|------------------------------|--------------------------------------------|
| [ 18 F]Fluro-2-deoxygluclose | Oncology, Neuro                            |
| [ 18 F]Fluoride (Na 18 F)    | Bone Metastasis                            |
| [ 18 F]Fluorothymidine       | Brain tumor, Osteosarcoma                  |
| 2-[ 18 F]Fluorotyrosine      | Cellualar aminoacid transport tumor        |
| [ 18 F]Fluorocholine         | Prostate carcinoma, soft tissue metastases |
| [ 18 F]FMIZO/[ 18 F] FAZA    | Hypoxia, therapy planning                  |
| [ 18 F]Fluoroestradiol       | Hormone receptor status in breast cancer   |
| [ 18 F] FD OPA               | NETs and pancreatic b cell hyperplasia     |

## ii) Other important radioisotopes for diagnostic and therapeutic uses

| Gallium-67   | Gallium-67 scintigraphy may include regional, whole-body, planar, and single photon emission computed tomography (SPECT) scintigrams, or any combination performed after intravenous injection of 67 Ga-citrate for Soft tissue tumor imaging.   |
|--------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Thallium-201 | Thallium-201 Chloride is a radiopharmaceutical used in myocardial perfusion imaging (MPI) using either planar or single photon emission computed tomography (SPECT) techniques for the diagnosis and localization of myocardial infarction.      |
| Paladium-103 | Prostate cancer therapy                                                                                                                                                                                                                          |
| Iodine-123   | Single photon emission computed tomography (SPECT) for thyroid cancer imaging and detection of primary or metastatic pheochromocytoma                                                                                                            |

(b)&(c)  Yes, Sir. The total cost of complete cyclotron systems is Rs.156.22 crore.

********