Lok Sabha Question No. 47 (STARRED), answered on 2020-02-05
Subject: Product Patent of Various Medicines
Ministry: COMMERCE AND INDUSTRY
Asked by: T.N. Prathapan

## GOVERNMENT OF INDIA MINISTRY OF COMMERCE & INDUSTRY DEPARTMENT FOR PROMOTION OF INDUSTRY AND INTERNAL TRADE

## LOK SABHA

## STARRED QUESTION NO. 47. TO BE ANSWERED ON WEDNESDAY, THE 05 TH  FEBRUARY, 2020.

## PRODUCT PATENT OF VARIOUS MEDICINES

## *47. SHRI T.N. PRATHAPAN:

Will the Minister of COMMERCE AND INDUSTRY be pleased to state:

वाणिज्य

## एवं उद्योग मंत्री

- (a) whether product patents are granted to medicines for the treatment of Human Immunodeficiency  Virus  (HIV),  Hepatitis  C  Virus  (HCV),  Tuberculosis  (TB), Cancer, Cardiovascular diseases and Diabetes; and
- (b) if  so,  the  details  of  the  patented  molecule  (International  Nonproprietary Names) along with the date of the patent application, date of the patent grant, patent application number, patent number, name of the patentee and expiry date of the patent in respect of medicines patented for the treatment of each of the above mentioned diseases?

## ANSWER वाणिज ् य एवं उद्योग मंत्री श्री पीयूष गोयल

## ( ) THE MINISTER OF COMMERCE & INDUSTRY (SHRI  PIYUSH GOYAL)

- (a) & (b): A Statement is laid on the Table of the House.

********

## STATEMENT REFERRD TO IN REPLY TO LOK SABHA STARRED QUESTION NO 47 FOR ANSWER ON 5 TH  FEBRUARY, 2020.

- (a): Yes, Sir.
- (b): Patent  Office  grants  patents  to  all  inventions  and  claims  made  therein. Details of patents granted since 01-01-2005 along with the date of filing of the patent application, date of the patent grant, patent application number, patent number and name of the patentee where the claims included reference to the above mentioned diseases are attached in Annexure-1 .

Patent term is uniformly 20 years from the date of filing as applicable, unless a patent is ceased because of non- renewal (non-payment of fee).

Further,  it  may  be  noted,  when  a  patent  is  applied  for,  International  Nonproprietary Name (INN) is generally not provided by the applicant; neither the same is required in the application as per rules. Therefore, it is not available.

It  may  also  be  noted  that  as  a  result  of  several  measures  taken  by  the Government of India, i) the time taken for examination of patent applications has been brought down from 72 months in 2014-15 to around 24-36 months at  present;  ii)  the  pendency  in  patent  examination  has  come  down  from 1,78,525 in FY 2014-15 to 81,271 in January 2020; and iii) the disposals have increased  from  14,316  in  FY  2014-15  to  48,751  in  FY 2019-20  till  January 2020.

*******

## ANNEXURE REFERRED TO IN REPLY TO PART (b) OF THE LOK SABHA STARRED QUESTION NO. 47 FOR ANSWER ON 5 TH FEBRUARY, 2020.

Patents Granted to various medicines for treatment of diseases (as mentioned)  from 1-1-2005 to 27-01-2020

|   S. No. | NAME OF DISEASE   | APPLICATION NUMBER    | DATE OF FILING   |   PATENT NUMBER | DATE OF GRANT   | PATENTEE NAME                                                      |
|----------|-------------------|-----------------------|------------------|-----------------|-----------------|--------------------------------------------------------------------|
|        1 | Cancer            | 453/CHENP/2003        | 01-04-2003       |          205180 | 22-03-2007      | F. HOFFMANN LA - ROCHE AG                                          |
|        2 | Cancer            | 2007/CHENP/2004       | 08-09-2004       |          205696 | 09-04-2007      | M/S. MERCK & CO . INC.                                             |
|        3 | Cancer            | 502/MUM/2003          | 19-05-2003       |          206652 | 04-05-2007      | SAHASRABUDHE DR. MADHAO BHALCHANDRA                                |
|        4 | Cancer            | 2798/CHENP/2004       | 10-12-2004       |          207639 | 19-06-2007      | M/S. MERCK & CO. INC                                          |
|        5 | Cancer            | 2645/MAS/1998         | 24-11-1998       |          209021 | 16-08-2007      | M/S. SCHERING CORPORATION                                          |
|        6 | Cancer            | 798/MAS/2001          | 25-09-2001       |          209079 | 20-08-2007      | DR. REDDY' S LABORATORIES LTD                                      |
|        7 | Cancer            | 282/CHE/2004          | 29-03-2004       |          209783 | 06-09-2007      | OMNIACTIVE HEALTH TECHNOLOGIES PVT LTD                             |
|        8 | Cancer            | 911/DEL/2002          | 05-09-2002       |          210537 | 05-10-2007      | NATIONAL INSTITUTE OF IMMUNOLOGY                                   |
|        9 | Cancer            | IN/PCT/2000/00777/MUM | 26-12-2000       |          210996 | 16-10-2007      | DAEWOONG PHARMACEUTICAL CO. LTD.                                   |
|       10 | Cancer            | 1022/DEL/2002         | 08-10-2002       |          211356 | 26-10-2007      | DABUR RESEARCH FOUNDATION                                          |
|       11 | Cancer            | 522/DEL/2000          | 19-05-2000       |          211476 | 01-11-2007      | DABUR RESEARCH FOUNDATION                                          |
|       12 | Cancer            | 147/DEL/2000          | 24-02-2000       |          211479 | 01-11-2007      | DABUR RESEARCH FOUNDATION                                          |
|       13 | Cancer            | 1/DEL/2001            | 01-01-2001       |          211483 | 01-11-2007      | DABUR RESEARCH FOUNDATION                                          |
|       14 | Cancer            | 943/KOLNP/2005        | 20-05-2005       |          212279 | 28-11-2007      | ELI LILLY AND COMPANY                                              |
|       15 | Cancer            | 2318/DELNP/2005       | 01-06-2005       |          215211 | 24-01-2008      | PHARMACIA ITALIA S.P.A.,                                           |
|       16 | Cancer            | 2880/CHENP/2004       | 17-12-2004       |          214370 | 11-02-2008      | N. V. ORGANON                                                      |
|       17 | Cancer            | IN/PCT/2002/01077/DEL | 30-10-2002       |          214740 | 15-02-2008      | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION. |
|       18 | Cancer            | 593/CAL/1999          | 30-06-1999       |          216362 | 12-03-2008      | DR. ALAKH MOHANMATHUR                                              |
|       19 | Cancer            | 108/CHE/2003          | 07-02-2003       |          216471 | 13-03-2008      | DR. REDDY`S LABORATORIES LTD.                                      |
|       20 | Cancer            | 379/KOLNP/2004        | 22-03-2004       |          217468 | 26-03-2008      | UNIVERSITY OF VICTORIA INNOVATION AND DEVELOPMENT CORPORATION      |
|       21 | Cancer            | 793/CHENP/2004        | 16-04-2004       |          218259 | 31-03-2008      | SCHERING CORPORATION                                               |
|       22 | Cancer            | IN/PCT/2002/00999/DEL | 07-10-2002       |          218620 | 03-04-2008      | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP                   |
|       23 | Cancer            | 57/CHENP/2005         | 24-01-2005       |          218816 | 16-04-2008      | PSIMEI PHARMACEUTICALS PLC                                         |
|       24 | Cancer            | 00514/DELNP/2003      | 04-04-2003       |          219396 | 05-05-2008      | BRISTOL-MYERS SQUIBB COMPANY                                       |
|       25 | Cancer            | 899/CHENP/2005        | 12-05-2005       |          220083 | 15-05-2008      | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION                        |

## ANNEXURE  1

|   26. | Cancer   | IN/PCT/2001/00899/DEL   | 03-10-2001   |   220809 | 05-06-2008   | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION   |
|-------|----------|-------------------------|--------------|----------|--------------|--------------------------------------------------------------------|
|    27 | Cancer   | IN/PCT/2000/130/KOL     | 12-07-2000   |   221017 | 11-06-2008   | GLAXO GROUP LIMITED                                                |
|    28 | Cancer   | 1798/DELNP/2004         | 24-06-2004   |   221048 | 12-06-2008   | SYNGENTA LIMITED                                                   |
|    29 | Cancer   | 1886/CHENP/2004         | 25-08-2004   |   221318 | 20-06-2008   | SCHERING CORPORATION                                               |
|    30 | Cancer   | 1093/DELNP/2005         | 21-03-2005   |   222436 | 08-08-2008   | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION   |
|    31 | Cancer   | 01757/DELNP/2003        | 28-10-2003   |   222458 | 12-08-2008   | KANSAI TECHNOLOGY LICENSING ORGANIZATION CO., LTD.                 |
|    32 | Cancer   | 369/CHENP/2005          | 11-03-2005   |   222661 | 20-08-2008   | REPLICOR INC                                                       |
|    33 | Cancer   | 3177/DELNP/2005         | 18-07-2005   |   222991 | 29-08-2008   | SURVAC ApS                                                         |
|    34 | Cancer   | 431/CAL/2000            | 28-07-2000   |   223396 | 10-09-2008   | ELI LILLY AND COMPANY                                              |
|    35 | Cancer   | IN/PCT/2002/01089/DEL   | 05-11-2002   |   223555 | 12-09-2008   | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION   |
|    36 | Cancer   | 929/CHE/2003            | 13-11-2003   |   223720 | 19-09-2008   | JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH           |
|    37 | Cancer   | IN/PCT/2001/1355/KOL    | 24-12-2001   |   223906 | 23-09-2008   | ZENTARIS GMBH                                                      |
|    38 | Cancer   | 1764/KOLNP/2004         | 22-11-2004   |   224749 | 22-10-2008   | CURE TECH LTD.                                                     |
|    39 | Cancer   | 1065/KOLNP/2005         | 03-06-2005   |   224977 | 29-10-2008   | AXYS PHARMACEUTICALS INC.                                          |
|    40 | Cancer   | 01354/KOLNP/2005        | 13-07-2005   |   225188 | 05-11-2008   | SHENZHEN CHIPSCREEN BIOCIENCES LTD.                                |
|    41 | Cancer   | 465/KOLNP/2003          | 16-04-2003   |   225209 | 05-11-2008   | ELI LILLY AND COMPANY                                              |
|    42 | Cancer   | 508/MAS/1998            | 12-03-1998   |   226319 | 17-12-2008   | ABBOTT GmbH & Co. KG                                               |
|    43 | Cancer   | 1355/MAS/1996           | 31-07-1996   |   227418 | 07-01-2009   | MITSUBISHI TANABE PHARMA CORPORATION                               |
|    44 | Cancer   | 1354/CHENP/2003         | 28-08-2003   |   227445 | 07-01-2009   | ICOS CORPORATION                                                   |
|    45 | Cancer   | 1428/CHENP/2003         | 11-09-2003   |   227446 | 07-01-2009   | AVENTIS PHARMA S.A                                                 |
|    46 | Cancer   | 1419/KOLNP/2005         | 21-07-2005   |   227630 | 14-01-2009   | ECOPIO BIOSCIENCES INC.                                            |
|    47 | Cancer   | 1605/MAS/1998           | 17-07-1998   |   227923 | 27-01-2009   | ABBOTT GmbH & Co. KG                                               |
|    48 | Cancer   | IN/PCT/2002/351/KOL     | 14-03-2002   |   228099 | 28-01-2009   | UNIVERSITY OF IOWA RESEARCH FOUNDATION                             |
|    49 | Cancer   | IN/PCT/2002/1927/CHE    | 22-11-2002   |   229250 | 16-02-2009   | ICOS CORPORATION                                                   |
|    50 | Cancer   | 445/KOLNP/2006          | 27-02-2006   |   229479 | 18-02-2009   | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND                  |
|    51 | Cancer   | IN/PCT/2001/359/CHE     | 15-03-2001   |   229651 | 19-02-2009   | IMMUNOBIOLOGY LIMITED                                              |
|    52 | Cancer   | 344/CHENP/2006          | 27-01-2006   |   229758 | 20-02-2009   | LABORATORIOS FARMACEUTICOS ROVI S.A                                |
|    53 | Cancer   | 1070/CHENP/2003         | 11-07-2003   |   230078 | 24-02-2009   | AMGEN INC                                                          |
|    54 | Cancer   | 2325/KOLNP/2005         | 21-11-2005   |   230182 | 25-02-2009   | ELILILLY AND COMPANY                                               |

|   55. | Cancer              | 2736/CHENP/2005       | 21-10-2005   |   230280 | 25-02-2009   | CENTRO DE IMMUNOLOGIA MOLECULAR                                            |
|-------|---------------------|-----------------------|--------------|----------|--------------|----------------------------------------------------------------------------|
|    56 | Cancer              | 84/CHENP/2006         | 06-01-2006   |   231165 | 03-03-2009   | MORINAGA MILK INDUSTRY CO., LTD                                            |
|    57 | Cancer              | 290/CHENP/2006        | 24-01-2006   |   231180 | 03-03-2009   | NOVARTIS AG                                                                |
|    58 | Cancer              | 2733/DEL/1997         | 24-09-1997   |   231489 | 05-03-2009   | ASTRAZENECA UK LIMITED                                                     |
|    59 | Cancer              | 2980/DELNP/2004       | 30-09-2004   |   231500 | 05-03-2009   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                |
|    60 | Cancer 663/DEL/2003 |                       | 02-05-2003   |   231606 | 06-03-2009   | DR. MANJU PATHAK                                                           |
|    61 | Cancer              | 1279/DEL/2003         | 16-10-2003   |   231705 | 09-03-2009   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                |
|    62 | Cancer              | 1149/DEL/2000         | 13-12-2000   |   232332 | 16-03-2009   | THE DIRCTOR, ALL INDIA INSTITUTE OF MEDICAL SCIENCES                       |
|    63 | Cancer              | IN/PCT/2001/01148/DEL | 11-12-2001   |   232353 | 16-03-2009   | AGOURON PHARAMACEUTICALS, INC.                                             |
|    64 | Cancer              | 456/DEL/2003          | 27-03-2003   |   232387 | 16-03-2009   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH                              |
|    65 | Cancer              | 792/DEL/2002          | 31-07-2002   |   232568 | 18-03-2009   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH                              |
|    66 | Cancer              | IN/PCT/2002/01079/DEL | 30-10-2002   |   232961 | 24-03-2009   | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION         |
|    67 | Cancer              | 3346/DELNP/2005       | 27-07-2005   |   233129 | 26-03-2009   | KABUSHIKI KAISHA YAKULT HONSHA                                             |
|    68 | Cancer              | IN/PCT/2002/01198/DEL | 05-12-2002   |   233148 | 27-03-2009   | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM  |
|    69 | Cancer              | IN/PCT/2002/01168/DEL | 28-11-2002   |   233235 | 27-03-2009   | BRISTOL-MYERS SQUIBB PHARMA COMPANY                                        |
|    70 | Cancer              | 384/DELNP/2006        | 20-01-2006   |   233339 | 28-03-2009   | JE IL PHARMACEUTICAL CO., LTD                                              |
|    71 | Cancer              | IN/PCT/2002/01197/DEL | 05-12-2002   |   233380 | 29-03-2009   | YISSUM RESEARCH DEVELPEMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM. |
|    72 | Cancer              | IN/PCT/2002/1998/CHE  | 04-12-2002   |   233717 | 02-04-2009   | THERACOS  INC                                                         |
|    73 | Cancer              | 01545/DELNP/2003      | 25-09-2003   |   234816 | 16-06-2009   | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION                              |
|    74 | Cancer              | IN/PCT/2001/00898/DEL | 03-10-2001   |   234904 | 19-06-2009   | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION          |
|    75 | Cancer              | 2680/DELNP/2005       | 17-06-2005   |   235365 | 01-07-2009   | DABUR PHARMA LIMITED                                                       |
|    76 | Cancer              | 3094/DELNP/2005       | 12-07-2005   |   235438 | 02-07-2009   | CANCER RESEARCH TECHNOLOGY LIMITED                                         |
|    77 | Cancer              | 2072/KOLNP/2005       | 21-10-2005   |   236057 | 17-09-2009   | JOULLIE MADELEINEM                                                         |
|    78 | Cancer              | 1507/DELNP/2003       | 19-09-2003   |   236268 | 14-10-2009   | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCTATION          |
|    79 | Cancer              | 204/DELNP/2004        | 29-01-2004   |   237446 | 22-12-2009   | LU, ZHIMIN                                                                 |
|    80 | Cancer              | 2718/KOLNP/2005       | 26-12-2005   |   237490 | 23-12-2009   | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.                           |
|    81 | Cancer              | 360/MAS/1999          | 30-03-1999   |   237614 | 29-12-2009   | TEMPLE UNIVERCITY                                                          |
|    82 | Cancer              | 5563/DELNP/2005       | 01-12-2005   |   238221 | 25-01-2010   | GEMIN X BIOTECHNOLOGIES INC.                                               |

|   83. | Cancer   | 761/KOLNP/2006       | 29-03-2006   |   238295 | 28-01-2010   | WYETH HOLDINGS CORPORATION                                                                         |
|-------|----------|----------------------|--------------|----------|--------------|----------------------------------------------------------------------------------------------------|
|    84 | Cancer   | 2379/KOLNP/2005      | 25-11-2005   |   238300 | 28-01-2010   | NIPPON KAYAKU KABUSHIKI KAISHA                                                                     |
|    85 | Cancer   | 19/CHENP/2005        | 18-01-2005   |   238907 | 25-02-2010   | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION                                                        |
|    86 | Cancer   | 3982/CHENP/2006      | 30-10-2006   |   239130 | 09-03-2010   | GALPHARMA CO. LTD                                                                                  |
|    87 | Cancer   | 2622/KOLNP/2005      | 19-12-2005   |   239843 | 06-04-2010   | ONKOMAX ACQUISITION CORP.                                                                          |
|    88 | Cancer   | 30/DELNP/2003        | 10-01-2003   |   240341 | 05-05-2010   | PHARMA MAR, S.A.                                                                                   |
|    89 | Cancer   | IN/PCT/2001/1011/CHE | 18-07-2001   |   241400 | 01-07-2010   | CORIXA CORPORATION                                                                                 |
|    90 | Cancer   | 1184/DEL/2004        | 25-06-2004   |   241416 | 02-07-2010   | The Secretary, Department of Biotechnology                                                         |
|    91 | Cancer   | 462/KOLNP/2005       | 18-03-2005   |   241844 | 28-07-2010   | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH                                                      |
|    92 | Cancer   | 747/DEL/2003         | 29-05-2003   |   242189 | 18-08-2010   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH                                                      |
|    93 | Cancer   | 1464/MUMNP/2006      | 30-11-2006   |   242762 | 09-09-2010   | UNIVERSITY OF VIRGINIA PATENT FOUNDATION                                                           |
|    94 | Cancer   | 2728/CHENP/2006      | 24-07-2006   |   243035 | 24-09-2010   | INFINITY DISCOVERY INC                                                                             |
|    95 | Cancer   | 6/CHENP/2007         | 02-01-2007   |   243781 | 04-11-2010   | VALTON TEKNILLINEN TUTKIMUSKESKUS                                                                  |
|    96 | Cancer   | 3668/DELNP/2005      | 18-08-2005   |   244474 | 08-12-2010   | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION                                 |
|    97 | Cancer   | 1441/CHENP/2006      | 27-04-2006   |   244504 | 08-12-2010   | BIOAXONE THERAPEUTIQUE INC.                                                                        |
|    98 | Cancer   | 232/CHENP/2007       | 19-01-2007   |   245115 | 03-01-2011   | M/S. SCHERING CORPORATION                                                                          |
|    99 | Cancer   | 984/CHENP/2005       | 20-05-2005   |   245117 | 03-01-2011   | M/S. THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS                                           |
|   100 | Cancer   | 4512/CHENP/2006      | 08-12-2006   |   245118 | 03-01-2011   | MACROGENICS, INC                                                                                   |
|   101 | Cancer   | 3436/KOLNP/2006      | 20-11-2006   |   245189 | 06-01-2011   | GLAXOSMITHKLINE BIOLOGICALS S.A.                                                                   |
|   102 | Cancer   | 1213/DELNP/2005      | 29-03-2005   |   245447 | 19-01-2011   | CANAG DIAGNOSTICS AB                                                                               |
|   103 | Cancer   | 1073/DELNP/2003      | 08-07-2003   |   245684 | 28-01-2011   | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMANSERVICES |
|   104 | Cancer   | 2417/DELNP/2006      | 01-05-2006   |   246211 | 21-02-2011   | BEIJING SUNBIO BIOTECH CO., LTD.                                                                   |
|   105 | Cancer   | 961/CHENP/2004       | 05-05-2004   |   246323 | 24-02-2011   | NOVARTIS AG                                                                                        |
|   106 | Cancer   | 1550/DELNP/2003      | 26-09-2003   |   246354 | 25-02-2011   | CENTRO DE IMMUNOLOGIA MOLECULAR                                                                    |
|   107 | Cancer   | 3849/CHENP/2007      | 04-09-2007   |   247131 | 29-03-2011   | SURVAC APS                                                                                         |
|   108 | Cancer   | 2333/KOLNP/2006      | 17-08-2006   |   248231 | 28-06-2011   | AVENTIS PHARMA S.A .                                                                               |
|   109 | Cancer   | 973/MUM/2006         | 21-06-2006   |   248435 | 14-07-2011   | RELIANCE LIFE SCIENCES PRIVATE LIMITED                                                             |
|   110 | Cancer   | 5666/DELNP/2006      | 28-09-2006   |   248545 | 25-07-2011   | DABUR PHARMA LTD                                                                                   |
|   111 | Cancer   | 7221/DELNP/2006      | 30-11-2006   |   248605 | 28-07-2011   | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY                                           |
|   112 | Cancer   | 3046/DELNP/2004      | 05-10-2004   |   248684 | 04-08-2011   | ARRAY BIOPHARMA INC                                                                                |

|   113. | Cancer   | 2261/CHENP/2006   | 22-06-2006   |   250163 | 13-12-2011   | KUBOYAMA BIOKEN CO., LTD.                                        |
|--------|----------|-------------------|--------------|----------|--------------|------------------------------------------------------------------|
|    114 | Cancer   | 84/MUMNP/2008     | 16-01-2008   |   250165 | 13-12-2011   | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS              |
|    115 | Cancer   | 930/KOLNP/2007    | 15-03-2007   |   250373 | 29-12-2011   | ENGENEIC MOLECULAR DELIVERY PTY LTD.                             |
|    116 | Cancer   | 699/MUM/2008      | 31-03-2008   |   250374 | 29-12-2011   | PIRAMAL LIFE SCIENCES LTD.                                       |
|    117 | Cancer   | 3183/DELNP/2006   | 02-06-2006   |   250807 | 30-01-2012   | ARRAY BIOPHARMA INC.                                             |
|    118 | Cancer   | 3158/DEL/2005     | 25-11-2005   |   251579 | 26-03-2012   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                      |
|    119 | Cancer   | 2978/DELNP/2008   | 10-04-2008   |   252491 | 18-05-2012   | KOWA CO. , LTD.                                                  |
|    120 | Cancer   | 963/MUMNP/2009    | 14-05-2009   |   252549 | 22-05-2012   | ELI LILLY AND COMPANY                                            |
|    121 | Cancer   | 3429/DELNP/2006   | 14-06-2006   |   252982 | 13-06-2012   | ASTEX THERAPEUTICS LIMITED                                       |
|    122 | Cancer   | 144/KOLNP/2007    | 11-01-2007   |   253477 | 25-07-2012   | NOVARTIS VACCINES AND DIAGNOSTICS, INC.                          |
|    123 | Cancer   | 1822/DEL/2006     | 14-08-2006   |   253782 | 24-08-2012   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                      |
|    124 | Cancer   | 1151/MUMNP/2009   | 16-06-2009   |   253922 | 03-09-2012   | ELI LILLY AND COMPANY                                            |
|    125 | Cancer   | 383/DEL/2006      | 13-02-2006   |   254250 | 09-10-2012   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH                    |
|    126 | Cancer   | 1424/CHENP/2008   | 24-03-2008   |   254730 | 12-12-2012   | EISAI R&D MANAGEMENT CO, LTD                                     |
|    127 | Cancer   | 1276/CHENP/2008   | 14-03-2008   |   255154 | 30-01-2013   | F. HOFFMANN-LA ROCHE AG                                          |
|    128 | Cancer   | 1423/DEL/2004     | 30-07-2004   |   255437 | 22-02-2013   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                      |
|    129 | Cancer   | 439/MUMNP/2008    | 07-03-2008   |   256105 | 02-05-2013   | NELSON, PETER, JON                                               |
|    130 | Cancer   | 2726/KOLNP/2007   | 24-07-2007   |   256132 | 07-05-2013   | CEPHALON, INC                                                    |
|    131 | Cancer   | 2096/MUMNP/2009   | 10-11-2009   |   256516 | 27-06-2013   | JANSSEN PHARMACEUTICA NV                                         |
|    132 | Cancer   | 3211/DELNP/2007   | 30-04-2007   |   257295 | 21-09-2013   | UNIVERSIDADE DE COIMBRA                                          |
|    133 | Cancer   | 688/KOLNP/2008    | 15-02-2008   |   258094 | 02-12-2013   | ARRAY BIOPHARMA INC.                                             |
|    134 | Cancer   | 257/KOLNP/2008    | 17-01-2008   |   258585 | 22-01-2014   | THRESHOLD PHARMACEUTICALS, INC.                                  |
|    135 | Cancer   | 5870/DELNP/2006   | 09-10-2006   |   258750 | 05-02-2014   | MERCK PATENT GMBH                                                |
|    136 | Cancer   | 2155/DELNP/2007   | 20-03-2007   |   258848 | 11-02-2014   | MARSHALL EDWARDS, INC.                                           |
|    137 | Cancer   | 743/DELNP/2007    | 29-01-2007   |   259583 | 19-03-2014   | PIERRE FABRE MEDICAMENT                                          |
|    138 | Cancer   | 642/KOLNP/2008    | 13-02-2008   |   259857 | 28-03-2014   | ARRAY BIOPHARMA, INC.                                            |
|    139 | Cancer   | 5625/DELNP/2006   | 26-09-2006   |   260127 | 31-03-2014   | HTL HIGH -TECH LIPIDS LTD                                        |
|    140 | Cancer   | 5372/DELNP/2006   | 18-09-2006   |   260374 | 28-04-2014   | ANTISENSE PHARMA GMBH                                            |
|    141 | Cancer   | 1823/DEL/2006     | 14-08-2006   |   260578 | 09-05-2014   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                      |
|    142 | Cancer   | 2277/CHENP/2007   | 25-05-2007   |   260682 | 16-05-2014   | CHUGAI SEIYAKU KABUSHIKI KAISHA                                  |
|    143 | Cancer   | 3561/KOLNP/2007   | 21-09-2007   |   260894 | 28-05-2014   | ICOS CORPORATION                                                 |
|    144 | Cancer   | 1508/DELNP/2006   | 21-03-2006   |   261112 | 04-06-2014   | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |

|   145. | Cancer   | 1327/CHE/2008   | 02-06-2008   |   261431 | 25-06-2014   | INDIAN INSTITUTE OF TECHNOLOGY                                            |
|--------|----------|-----------------|--------------|----------|--------------|---------------------------------------------------------------------------|
|    146 | Cancer   | 1936/DEL/2006   | 29-08-2006   |   261615 | 02-07-2014   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                               |
|    147 | Cancer   | 3184/DELNP/2007 | 27-04-2007   |   261711 | 09-07-2014   | TOPIGEN PHARMACEUTICALS INC.                                              |
|    148 | Cancer   | 215/KOLNP/2008  | 15-01-2008   |   262273 | 11-08-2014   | AVENTIS PHARMA S.A.                                                       |
|    149 | Cancer   | 6360/DELNP/2008 | 21-07-2008   |   262425 | 21-08-2014   | STATHOPOULOS, APOSTOLOS                                                   |
|    150 | Cancer   | 1626/DEL/2007   | 01-08-2007   |   262806 | 16-09-2014   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                               |
|    151 | Cancer   | 278/DEL/2007    | 13-02-2007   |   263345 | 21-10-2014   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                               |
|    152 | Cancer   | 3234/CHENP/2008 | 23-06-2008   |   263429 | 29-10-2014   | AMGEN INC.                                                                |
|    153 | Cancer   | 758/DELNP/2008  | 28-01-2008   |   264093 | 04-12-2014   | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM |
|    154 | Cancer   | 4082/KOLNP/2007 | 24-10-2007   |   264608 | 09-01-2015   | AUCKLAND UNISERVICES LIMITED                                              |
|    155 | Cancer   | 4630/DELNP/2008 | 29-05-2008   |   264822 | 23-01-2015   | IBC PHARMACEUTICALS, INC.                                                 |
|    156 | Cancer   | 733/DELNP/2008  | 25-01-2008   |   265497 | 25-02-2015   | NOVARTIS AG.,                                                             |
|    157 | Cancer   | 1952/DELNP/2008 | 05-03-2008   |   265561 | 27-02-2015   | TUK RAI JEONG                                                             |
|    158 | Cancer   | 288/DELNP/2008  | 10-01-2008   |   265586 | 27-02-2015   | IL-YANG PHARM CO., LTD.                                                   |
|    159 | Cancer   | 1131/CHENP/2006 | 03-04-2006   |   266465 | 07-05-2015   | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION                             |
|    160 | Cancer   | 2471/KOLNP/2007 | 04-07-2007   |   266863 | 10-06-2015   | GENE TECHNO SCIENCE CO., LTD.                                             |
|    161 | Cancer   | 7017/DELNP/2007 | 11-09-2007   |   267371 | 16-07-2015   | KABUSHIKI KAISHA YAKULT HONSHA                                            |
|    162 | Cancer   | 1259/KOLNP/2009 | 02-04-2009   |   267832 | 31-07-2015   | DAIICHI SANKYO COMPANY, LIMITED                                           |
|    163 | Cancer   | 277/DEL/2007    | 13-02-2007   |   268235 | 22-08-2015   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH                             |
|    164 | Cancer   | 2153/DELNP/2008 | 12-03-2008   |   268931 | 23-09-2015   | ASTEX PHARMACEUTICALS, INC.                                               |
|    165 | Cancer   | 7581/DELNP/2009 | 23-11-2009   |   268939 | 24-09-2015   | INSTITUTE OF PROBLEMS OF CHEMICAL PHYSICS RAS (IPCP RAS)                  |
|    166 | Cancer   | 1505/DELNP/2008 | 21-02-2008   |   269879 | 14-11-2015   | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION          |
|    167 | Cancer   | 5425/DELNP/2008 | 23-06-2008   |   270471 | 23-12-2015   | GENENTECH, INC.                                                           |
|    168 | Cancer   | 238/MUMNP/2010  | 05-02-2010   |   270844 | 22-01-2016   | DIATECH KOREA CO. LTD.                                                    |
|    169 | Cancer   | 5488/DELNP/2008 | 24-06-2008   |   271206 | 09-02-2016   | POSCO                                                                     |
|    170 | Cancer   | 3052/CHENP/2009 | 01-06-2009   |   271317 | 16-02-2016   | CHINA MEDICAL UNIVERSITY                                                  |
|    171 | Cancer   | 261/DELNP/2008  | 10-01-2008   |   271696 | 29-02-2016   | MERCK SHARP & DOHME CORP                                              |
|    172 | Cancer   | 1586/CHENP/2010 | 19-03-2010   |   272517 | 05-04-2016   | ONCOTHERAPY SCIENCE, INC                                                  |
|    173 | Cancer   | 266/MUM/2011    | 31-01-2011   |   272675 | 19-04-2016   | INDIAN INSTITUTE OF TECHNOLOGY,BOMBAY                                     |
|    174 | Cancer   | 3333/CHENP/2008 | 27-06-2008   |   273251 | 27-05-2016   | ASTELLAS PHARMA INC.                                                      |
|    175 | Cancer   | 7120/DELNP/2009 | 04-11-2009   |   273260 | 27-05-2016   | DONGWOO SYNTECH CO., LTD.                                                 |

|   176. | Cancer   | 10168/DELNP/2008   | 08-12-2008   |   273290 | 30-05-2016   | CUREVAC GMBH                                                                                       |
|--------|----------|--------------------|--------------|----------|--------------|----------------------------------------------------------------------------------------------------|
|    177 | Cancer   | 2541/CHENP/2008    | 22-05-2008   |   273334 | 31-05-2016   | GANYMED PHARMACEUTICALS AG, JOHANNES GUTENBERG- UNIVERSITAT MAINZ, VERTRETEN DURCH DEN PRASIDENTEN |
|    178 | Cancer   | 2646/DELNP/2009    | 22-04-2009   |   273868 | 30-06-2016   | BRISTOL-MYERS SQUIBB COMPANY                                                                       |
|    179 | Cancer   | 1266/CHENP/2010    | 05-03-2010   |   274868 | 11-08-2016   | REGENERON PHARMACEUTICALS, INC.                                                                    |
|    180 | Cancer   | 2912/CHENP/2008    | 11-06-2008   |   274966 | 16-08-2016   | MERCK SHARP & DHOME CORP.                                                                          |
|    181 | Cancer   | 2598/DEL/2008      | 19-11-2008   |   275269 | 30-08-2016   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                        |
|    182 | Cancer   | 3482/CHENP/2008    | 04-07-2008   |   276190 | 04-10-2016   | MEDAREX LLC                                                                                        |
|    183 | Cancer   | 1597/MUMNP/2010    | 24-07-2010   |   276300 | 13-10-2016   | TENSHINDO PHARMACEUTICAL CO., LTD.                                                                 |
|    184 | Cancer   | 6772/CHENP/2008    | 10-12-2008   |   276825 | 01-11-2016   | NIPPON CHEMICAL INDUSTRIAL CO., LTD                                                                |
|    185 | Cancer   | 4956/CHENP/2009    | 24-08-2009   |   276882 | 03-11-2016   | INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC                                                  |
|    186 | Cancer   | 10509/DELNP/2008   | 19-12-2008   |   277396 | 21-11-2016   | ONYX THERAPEUTICS, INC.                                                                            |
|    187 | Cancer   | 350/MUM/2009       | 18-02-2009   |   277986 | 07-12-2016   | UNICHEM LABORATORIES LTD.                                                                          |
|    188 | Cancer   | 7696/DELNP/2008    | 11-09-2008   |   278095 | 14-12-2016   | NOVOVACS HOLDING B.V.                                                                              |
|    189 | Cancer   | 5058/DELNP/2009    | 04-08-2009   |   278395 | 21-12-2016   | NOVARTIS AG                                                                                        |
|    190 | Cancer   | 2035/DELNP/2005    | 12-05-2005   |   278463 | 23-12-2016   | VAXum LLC                                                                                          |
|    191 | Cancer   | 3701/KOLNP/2009    | 23-10-2009   |   278734 | 29-12-2016   | HUTCHISON MEDIPHARMA ENTERPRISES LTD.                                                              |
|    192 | Cancer   | 4623/DELNP/2010    | 25-06-2010   |   278970 | 05-01-2017   | CUREVAC GMBH                                                                                       |
|    193 | Cancer   | 4182/KOLNP/2010    | 08-11-2010   |   279196 | 13-01-2017   | NATIONAL HEALTH RESEARCH INSTITUTES                                                                |
|    194 | Cancer   | 1854/CHENP/2008    | 15-04-2008   |   279563 | 25-01-2017   | ENDECE, LLC                                                                                        |
|    195 | Cancer   | 861/CHENP/2008     | 20-02-2008   |   280313 | 16-02-2017   | ARDEA BIOSCIENCES, INC                                                                             |
|    196 | Cancer   | 8481/DELNP/2009    | 24-12-2009   |   280322 | 16-02-2017   | HANMI SCIENCE CO., LTD.                                                                            |
|    197 | Cancer   | 2997/KOLNP/2009    | 24-08-2009   |   280471 | 21-02-2017   | MERCK & CIE                                                                                        |
|    198 | Cancer   | 787/DEL/2008       | 26-03-2008   |   280843 | 28-02-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                        |
|    199 | Cancer   | 1522/KOLNP/2010    | 30-04-2010   |   280909 | 28-02-2017   | MMVMEDICINES FOR MALARIA VENTURE                                                                   |
|    200 | Cancer   | 4157/CHENP/2009    | 15-07-2009   |   281246 | 10-03-2017   | NERVIANO MEDICAL SCIENCES S.R.L.                                                                   |
|    201 | Cancer   | 6279/CHENP/2008    | 18-11-2008   |   281617 | 22-03-2017   | ARDEA BIOSCIENCES, INC.                                                                            |
|    202 | Cancer   | 4097/DELNP/2010    | 08-06-2010   |   281735 | 24-03-2017   | PEREGRINE PHARMACEUTICALS, INC.                                                                    |
|    203 | Cancer   | 3543/KOLNP/2009    | 12-10-2009   |   282013 | 29-03-2017   | YM BIOSCIENCES AUSTRALIA PTY LTD                                                                   |
|    204 | Cancer   | 602/DEL/2008       | 11-03-2008   |   282164 | 31-03-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                        |
|    205 | Cancer   | 4329/DELNP/2008    | 21-05-2008   |   282487 | 12-04-2017   | SUTTER WEST BAY HOSPITALS                                                                          |

|   206. | Cancer   | 5660/DELNP/2006   | 28-09-2006   |   282579 | 18-04-2017   | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION   |
|--------|----------|-------------------|--------------|----------|--------------|--------------------------------------------------------------------|
|    207 | Cancer   | 2008/CHENP/2007   | 10-05-2007   |   282764 | 25-04-2017   | MACROGENICS, INC                                                   |
|    208 | Cancer   | 1743/KOLNP/2008   | 30-04-2008   |   283351 | 17-05-2017   | WYETH                                                              |
|    209 | Cancer   | 517/DEL/2008      | 05-03-2008   |   283471 | 23-05-2017   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH                      |
|    210 | Cancer   | 1488/CHENP/2009   | 16-03-2009   |   283858 | 31-05-2017   | SAMYANG BIOPHARMACEUTICALS CORPORATION                             |
|    211 | Cancer   | 5152/CHENP/2009   | 02-09-2009   |   284064 | 08-06-2017   | INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC                  |
|    212 | Cancer   | 603/DEL/2008      | 11-03-2008   |   284153 | 12-06-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                        |
|    213 | Cancer   | 785/DEL/2008      | 26-03-2008   |   284169 | 13-06-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                        |
|    214 | Cancer   | 205/CHE/2010      | 27-01-2010   |   284811 | 30-06-2017   | KULATHU IYER SATHIYANARAYANAN                                      |
|    215 | Cancer   | 4254/KOLNP/2010   | 12-11-2010   |   284850 | 30-06-2017   | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED                           |
|    216 | Cancer   | 9190/DELNP/2007   | 28-11-2007   |   284901 | 04-07-2017   | WNTRESEARCH AB                                                     |
|    217 | Cancer   | 2540/DEL/2008     | 07-11-2008   |   285045 | 11-07-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                        |
|    218 | Cancer   | 528/DEL/2008      | 05-03-2008   |   285048 | 11-07-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                        |
|    219 | Cancer   | 2121/DEL/2009     | 13-10-2009   |   285355 | 18-07-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                        |
|    220 | Cancer   | 594/DEL/2007      | 19-03-2007   |   285450 | 20-07-2017   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH                      |
|    221 | Cancer   | 5299/KOLNP/2008   | 30-12-2008   |   285456 | 20-07-2017   | SUNESIS PHARMACEUTICALS                                            |
|    222 | Cancer   | 1633/KOLNP/2010   | 07-05-2010   |   285535 | 24-07-2017   | CHOONGWAE PHARMA CORPORATION                                       |
|    223 | Cancer   | 7014/CHENP/2009   | 27-11-2009   |   285585 | 25-07-2017   | GANYMED PHARMACEUTICALS AG                                         |
|    224 | Cancer   | 484/DELNP/2008    | 17-01-2008   |   285648 | 26-07-2017   | INSTITUT PASTEUR                                                   |
|    225 | Cancer   | 1962/KOLNP/2009   | 25-05-2009   |   286624 | 24-08-2017   | INCYTE HOLDINGS CORPORATION                                        |
|    226 | Cancer   | 1317/CHENP/2009   | 09-03-2009   |   286682 | 28-08-2017   | CHUGAI SEIYAKU KABUSHIKI KAISHA                                    |
|    227 | Cancer   | 252/DEL/2007      | 07-02-2007   |   286707 | 28-08-2017   | NATIONAL INSTITUTE OF IMMUNOLOGY                                   |
|    228 | Cancer   | 2778/CHENP/2010   | 11-05-2010   |   286924 | 31-08-2017   | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY                 |
|    229 | Cancer   | 618/DEL/2008      | 11-03-2008   |   287045 | 04-09-2017   | SUJOY KUMAR GUHA                                                   |
|    230 | Cancer   | 1611/KOLNP/2010   | 06-05-2010   |   287051 | 04-09-2017   | CHOONGWAE PHARMA CORPORATION                                       |
|    231 | Cancer   | 4018/DELNP/2005   | 07-09-2005   |   287343 | 13-09-2017   | BOEHRINGER INGELHEIM INTERNATIONAL GMBH                            |
|    232 | Cancer   | 6202/DELNP/2010   | 01-09-2010   |   287752 | 25-09-2017   | OTSUKA PHARMACEUTICAL CO., LTD.                                    |
|    233 | Cancer   | 2557/MUMNP/2010   | 02-12-2010   |   288386 | 13-10-2017   | RAMOT AT TEL AVIV UNIVERSITY LTD.                                  |
|    234 | Cancer   | 4514/KOLNP/2008   | 07-11-2008   |   288573 | 23-10-2017   | BIOALLIANCE C.V.                                                   |
|    235 | Cancer   | 2739/CHENP/2012   | 26-03-2012   |   288629 | 24-10-2017   | F. HOFFMANN-LA ROCHE AG                                            |
|    236 | Cancer   | 1249/DELNP/2012   | 10-02-2012   |   289292 | 07-11-2017   | CHUGAI SEIYAKU KABUSHIKI KAISHA                                    |

|   237. | Cancer   | 1929/CHENP/2006   | 01-06-2006   |   289667 | 16-11-2017   | CHUGAI SEIYAKU KABUSHIKI KAISHA                                                |
|--------|----------|-------------------|--------------|----------|--------------|--------------------------------------------------------------------------------|
|    238 | Cancer   | 127/DEL/2010      | 22-01-2010   |   290351 | 06-12-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                    |
|    239 | Cancer   | 2886/DEL/2010     | 06-12-2010   |   290366 | 07-12-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                    |
|    240 | Cancer   | 392/DEL/2011      | 15-02-2011   |   290369 | 07-12-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                    |
|    241 | Cancer   | 1977/KOLNP/2008   | 16-05-2008   |   290388 | 07-12-2017   | TAKEDA PHARMACEUTICAL COMPANY LIMITED                                          |
|    242 | Cancer   | 7876/DELNP/2006   | 26-12-2006   |   290535 | 13-12-2017   | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION               |
|    243 | Cancer   | 2651/DELNP/2004   | 09-09-2004   |   290561 | 13-12-2017   | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION               |
|    244 | Cancer   | 7783/DELNP/2007   | 10-10-2007   |   290802 | 19-12-2017   | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED                                 |
|    245 | Cancer   | 2754/CHENP/2009   | 15-05-2009   |   291087 | 27-12-2017   | Momotaro-Gene Inc.                                                             |
|    246 | Cancer   | 68/DEL/2010       | 12-01-2010   |   291423 | 05-01-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                    |
|    247 | Cancer   | 953/DEL/2007      | 03-05-2007   |   291453 | 05-01-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                    |
|    248 | Cancer   | 5903/DELNP/2006   | 10-10-2006   |   291644 | 11-01-2018   | APREA AB                                                                       |
|    249 | Cancer   | 2769/DEL/2011     | 22-09-2011   |   291668 | 12-01-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                    |
|    250 | Cancer   | 2846/DELNP/2010   | 23-04-2010   |   291707 | 15-01-2018   | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. |
|    251 | Cancer   | 1312/KOLNP/2010   | 13-04-2010   |   291818 | 17-01-2018   | EISAI INC.                                                                     |
|    252 | Cancer   | 858/KOL/2007      | 07-06-2007   |   291906 | 19-01-2018   | DR. SUBHASIS ROY                                                               |
|    253 | Cancer   | 149/DELNP/2009    | 09-01-2009   |   292047 | 23-01-2018   | SCHERING CORPORATION                                                           |
|    254 | Cancer   | 6335/DELNP/2012   | 18-07-2012   |   292442 | 31-01-2018   | POXEL                                                                          |
|    255 | Cancer   | 7502/CHENP/2009   | 22-12-2009   |   292772 | 09-02-2018   | CENTRO DE INMUNOLOGIA MOLECULAR                                                |
|    256 | Cancer   | 2843/DELNP/2011   | 18-04-2011   |   292779 | 12-02-2018   | GENENTECH, INC.                                                                |
|    257 | Cancer   | 7410/DELNP/2009   | 16-11-2009   |   292987 | 16-02-2018   | HELPERBY THERAPEUTICS LIMITED                                                  |
|    258 | Cancer   | 2697/DEL/2010     | 11-11-2010   |   293591 | 28-02-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                    |
|    259 | Cancer   | 3561/DELNP/2010   | 20-05-2010   |   293727 | 01-03-2018   | BAYER INTELLECTUAL PROPERTY GMBH                                               |
|    260 | Cancer   | 2039/MUM/2010     | 16-07-2010   |   293782 | 05-03-2018   | DR. RUCHIKA KAUL-GHANEKAR                                                      |
|    261 | Cancer   | 3538/MUM/2010     | 24-12-2010   |   294015 | 09-03-2018   | AVANCE PHYTOTHERAPIES PVT. LTD.                                                |
|    262 | Cancer   | 4862/KOLNP/2007   | 13-12-2007   |   294295 | 14-03-2018   | E. R. Squibb & Sons, LLC                                                       |
|    263 | Cancer   | 152/CHENP/2012    | 04-01-2012   |   294424 | 16-03-2018   | CHUGAI SEIYAKU KABUSHIKI KAISHA                                                |
|    264 | Cancer   | 647/DELNP/2012    | 23-01-2012   |   294493 | 19-03-2018   | CHEN, DAGANG                                                                   |
|    265 | Cancer   | 2595/DELNP/2009   | 21-04-2009   |   294701 | 21-03-2018   | CARMON LIOR                                                                    |
|    266 | Cancer   | 307/CHENP/2011    | 14-01-2011   |   294790 | 23-03-2018   | ONCOTHERAPY SCIENCE, INC.                                                      |
|    267 | Cancer   | 4839/DELNP/2010   | 05-07-2010   |   294813 | 23-03-2018   | AMGEN INC.                                                                     |

|   268. | Cancer   | 1219/DELNP/2011   | 18-02-2011   |   295098 | 28-03-2018   | IBC PHARMACEUTICALS, INC.                              |
|--------|----------|-------------------|--------------|----------|--------------|--------------------------------------------------------|
|    269 | Cancer   | 597/CHE/2010      | 08-03-2010   |   295248 | 28-03-2018   | NATCO PHARMA LIMITED                                   |
|    270 | Cancer   | 22/CHENP/2011     | 04-01-2011   |   295395 | 02-04-2018   | PRISM BioLab Corporation                               |
|    271 | Cancer   | 1945/DEL/2004     | 07-10-2004   |   295616 | 09-04-2018   | NATIONAL INSTITUTE OF IMMUNOLOGY                       |
|    272 | Cancer   | 1843/DEL/2010     | 05-08-2010   |   295689 | 11-04-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH            |
|    273 | Cancer   | 2973/DEL/2010     | 13-12-2010   |   296365 | 01-05-2018   | THE REGISTRAR, BIRLA INSTITUTE OF TECHNOLOGY & SCIENCE |
|    274 | Cancer   | 2653/MUMNP/2012   | 29-11-2012   |   296393 | 01-05-2018   | TaiRx Inc.                                             |
|    275 | Cancer   | 2890/DEL/2010     | 06-12-2010   |   296587 | 07-05-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH            |
|    276 | Cancer   | 345/MUM/2013      | 06-02-2013   |   297486 | 07-06-2018   | DR AJIT HIRACHAND MANIKSHETE                           |
|    277 | Cancer   | 158/MUMNP/2012    | 19-01-2012   |   297616 | 13-06-2018   | TRANSLATIONAL DRUG DEVELOPMENT, LLC                    |
|    278 | Cancer   | 3694/DELNP/2009   | 05-06-2009   |   297681 | 15-06-2018   | TOLERO PHARMACEUTICALS, INC.                           |
|    279 | Cancer   | 368/DEL/2011      | 14-02-2011   |   298164 | 27-06-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH            |
|    280 | Cancer   | 2736/KOLNP/2009   | 27-07-2009   |   298270 | 29-06-2018   | SYMPHOGEN A.S                                          |
|    281 | Cancer   | 3085/DELNP/2012   | 10-04-2012   |   298938 | 18-07-2018   | MERCK SHARP & DOHME CORP                               |
|    282 | Cancer   | 5968/CHENP/2012   | 06-07-2012   |   299539 | 31-07-2018   | SUZHOU NEUPHARMA CO. LTD.                              |
|    283 | Cancer   | 1813/KOLNP/2010   | 19-05-2010   |   299564 | 31-07-2018   | INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC.     |
|    284 | Cancer   | 1759/CHENP/2011   | 14-03-2011   |   299612 | 01-08-2018   | F. HOFFMANN-LA ROCHE AG                                |
|    285 | Cancer   | 391/DEL/2011      | 15-02-2011   |   300011 | 16-08-2018   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH          |
|    286 | Cancer   | 2602/DEL/2008     | 19-11-2008   |   300026 | 16-08-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH            |
|    287 | Cancer   | 6564/DELNP/2008   | 28-07-2008   |   300041 | 17-08-2018   | YISHENG BIOPHARMA (SINGAPORE) PTE LTD.                 |
|    288 | Cancer   | 1606/CHENP/2011   | 07-03-2011   |   300086 | 20-08-2018   | AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH (A*STAR)    |
|    289 | Cancer   | 1760/CHENP/2012   | 27-02-2012   |   300098 | 20-08-2018   | BRISTOL-MYERS SQUIBB COMPANY                           |
|    290 | Cancer   | 2600/DEL/2008     | 19-11-2008   |   300470 | 29-08-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH            |
|    291 | Cancer   | 924/DEL/2006      | 31-03-2006   |   300638 | 31-08-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH            |
|    292 | Cancer   | 6810/CHENP/2012   | 02-08-2012   |   300841 | 07-09-2018   | F. HOFFMANN LA ROCHE AG                                |
|    293 | Cancer   | 8953/CHENP/2011   | 02-12-2011   |   300930 | 11-09-2018   | PRISM BioLab Co., Ltd                                  |
|    294 | Cancer   | 1192/MUMNP/2013   | 19-06-2013   |   301856 | 04-10-2018   | MEDPACTO INC.                                          |
|    295 | Cancer   | 6974/CHENP/2013   | 29-08-2013   |   301950 | 08-10-2018   | NATCO PHARMA LIMITED                                   |
|    296 | Cancer   | 338/MUMNP/2012    | 09-02-2012   |   302003 | 09-10-2018   | Ensol Biosciences lnc.                                 |
|    297 | Cancer   | 10411/CHENP/2012  | 13-12-2012   |   302155 | 12-10-2018   | APOSENSE LTD.                                          |
|    298 | Cancer   | 10636/DELNP/2008  | 24-12-2008   |   302163 | 12-10-2018   | BRISTOL-MYERS SQUIBB COMPANY                           |

|   299. | Cancer   | 2352/CHENP/2014   | 27-03-2014   |   302181 | 12-10-2018   | DONGGUK UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION                                                                                    |
|--------|----------|-------------------|--------------|----------|--------------|------------------------------------------------------------------------------------------------------------------------------------------------|
|    300 | Cancer   | 537/DEL/2008      | 05-03-2008   |   302219 | 15-10-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                                                                    |
|    301 | Cancer   | 3127/DELNP/2012   | 11-04-2012   |   302233 | 16-10-2018   | WUZHANGGUI                                                                                                                                     |
|    302 | Cancer   | 8504/DELNP/2010   | 30-11-2010   |   302292 | 18-10-2018   | GENENTECH, INC.                                                                                                                                |
|    303 | Cancer   | 1044/DELNP/2011   | 11-02-2011   |   302381 | 24-10-2018   | ACADEMIA SINICA                                                                                                                                |
|    304 | Cancer   | 3636/CHENP/2013   | 08-05-2013   |   302486 | 26-10-2018   | CENTRO DE INMUNOLOGIA MOLECULAR                                                                                                                |
|    305 | Cancer   | 1523/KOLNP/2013   | 16-05-2013   |   302828 | 01-11-2018   | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH                                                                                        |
|    306 | Cancer   | 3554/DELNP/2011   | 12-05-2011   |   302870 | 02-11-2018   | IPSEN BIOINNOVATION LIMITED                                                                                                                    |
|    307 | Cancer   | 678/DEL/2010      | 22-03-2010   |   303279 | 20-11-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                                                                    |
|    308 | Cancer   | 263/KOLNP/2011    | 17-01-2011   |   303441 | 26-11-2018   | TORAY INDUSTRIES, INC.                                                                                                                         |
|    309 | Cancer   | 848/KOLNP/2012    | 09-04-2012   |   304033 | 05-12-2018   | ORION CORPORATION                                                                                                                              |
|    310 | Cancer   | 3448/KOLNP/2012   | 08-11-2012   |   304203 | 07-12-2018   | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OFNEW YORK                                                                                     |
|    311 | Cancer   | 4538/CHENP/2013   | 13-06-2013   |   304238 | 10-12-2018   | GENENTECH, INC.,                                                                                                                               |
|    312 | Cancer   | 3348/DELNP/2012   | 18-04-2012   |   304312 | 11-12-2018   | LES LABORATOIRES SERVIER,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE(INSERM),CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
|    313 | Cancer   | 4558/DELNP/2011   | 15-06-2011   |   304364 | 12-12-2018   | ONCOS THERAPEUTICS OY                                                                                                                          |
|    314 | Cancer   | 2887/DEL/2010     | 06-12-2010   |   304893 | 24-12-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                                                                    |
|    315 | Cancer   | 324/CHE/2015      | 22-01-2015   |   305304 | 03-01-2019   | UNIVERSITY OF MYSORE                                                                                                                           |
|    316 | Cancer   | 10507/CHENP/2012  | 17-12-2012   |   305498 | 09-01-2019   | CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA                                                                                                  |
|    317 | Cancer   | 1865/DELNP/2011   | 11-03-2011   |   305511 | 09-01-2019   | GANYMED PHARMACEUTICALS AG                                                                                                                     |
|    318 | Cancer   | 4901/DELNP/2010   | 06-07-2010   |   305571 | 10-01-2019   | BIOALLIANCE C.V.                                                                                                                               |
|    319 | Cancer   | 390/DEL/2011      | 15-02-2011   |   305759 | 16-01-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                                                                    |
|    320 | Cancer   | 4878/DELNP/2013   | 31-05-2013   |   305947 | 21-01-2019   | CENTAURUS BIOPHARMA CO. LTD.                                                                                                                   |
|    321 | Cancer   | 6111/CHE/2013     | 26-12-2013   |   306301 | 25-01-2019   | Indian Institute of Science                                                                                                                    |
|    322 | Cancer   | 10233/CHENP/2012  | 06-12-2012   |   306307 | 25-01-2019   | NOVOMEDIX LLC                                                                                                                                  |
|    323 | Cancer   | 3157/DELNP/2013   | 10-04-2013   |   306952 | 07-02-2019   | ADVENCHEN LABORATORIES LLC                                                                                                                     |
|    324 | Cancer   | 1383/DEL/2011     | 11-05-2011   |   307338 | 13-02-2019   | TAIPEI MEDICAL UNIVERSITY                                                                                                                      |
|    325 | Cancer   | 3246/DEL/2011     | 15-11-2011   |   307621 | 19-02-2019   | NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH (NIPER)                                                                            |
|    326 | Cancer   | 2595/KOLNP/2013   | 23-08-2013   |   307781 | 21-02-2019   | GLAXO GROUP LIMITED                                                                                                                            |

|   327. | Cancer   | 3358/CHENP/2011   | 16-05-2011   |   308012 | 25-02-2019   | OncoTherapy Science, Inc.                                           |
|--------|----------|-------------------|--------------|----------|--------------|---------------------------------------------------------------------|
|    328 | Cancer   | 270/DEL/2011      | 04-02-2011   |   308121 | 26-02-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                         |
|    329 | Cancer   | 8036/CHENP/2014   | 31-10-2014   |   308148 | 26-02-2019   | NERVIANO MEDICAL SCIENCES S.R.L.                                    |
|    330 | Cancer   | 2439/CHE/2009     | 08-10-2009   |   308182 | 27-02-2019   | INCOZEN THERAPEUTICS PVT. LTD.                                      |
|    331 | Cancer   | 8004/DELNP/2009   | 08-12-2009   |   308650 | 06-03-2019   | DOGWOOD PHARMACEUTICALS, INC.                                       |
|    332 | Cancer   | 6350/DELNP/2014   | 28-07-2014   |   309086 | 12-03-2019   | ABBVIE INC.                                                         |
|    333 | Cancer   | 6358/DELNP/2011   | 19-08-2011   |   309306 | 15-03-2019   | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD                            |
|    334 | Cancer   | 1383/KOLNP/2012   | 06-06-2012   |   309769 | 25-03-2019   | TISSUE THERAPIES LIMITED                                            |
|    335 | Cancer   | 6789/CHENP/2015   | 30-10-2015   |   310088 | 27-03-2019   | ALMAC DISCOVERY LIMITED                                             |
|    336 | Cancer   | 6649/CHENP/2012   | 27-07-2012   |   310190 | 28-03-2019   | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY      |
|    337 | Cancer   | 10374/CHENP/2013  | 31-12-2013   |   310673 | 01-04-2019   | ARBOR THERAPEUTICS LLC                                              |
|    338 | Cancer   | 5701/CHENP/2012   | 29-06-2012   |   310913 | 05-04-2019   | BIOSCEPTRE (AUST)PTY LTD.                                           |
|    339 | Cancer   | 2279/MUMNP/2012   | 26-09-2012   |   311598 | 25-04-2019   | TAIPEI MEDICAL UNIVERSITY                                           |
|    340 | Cancer   | 2568/DEL/2013     | 30-08-2013   |   311859 | 29-04-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                         |
|    341 | Cancer   | 3123/CHENP/2012   | 04-04-2012   |   312060 | 30-04-2019   | PANACELA LABS, LLC                                                  |
|    342 | Cancer   | 2428/CHENP/2013   | 28-03-2013   |   313304 | 28-05-2019   | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH                  |
|    343 | Cancer   | 3309/MUM/2010     | 06-12-2010   |   313740 | 04-06-2019   | MANGE RAM YADAV                                                     |
|    344 | Cancer   | 3558/DEL/2013     | 09-12-2013   |   313805 | 06-06-2019   | NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH (NIPER) |
|    345 | Cancer   | 207/DEL/2011      | 31-01-2011   |   314002 | 11-06-2019   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH                       |
|    346 | Cancer   | 8445/CHENP/2012   | 03-10-2012   |   314747 | 26-06-2019   | ONCOTHERAPY SCIENCE INC.                                            |
|    347 | Cancer   | 5005/KOLNP/2010   | 28-12-2010   |   314985 | 27-06-2019   | Academia Sinica                                                     |
|    348 | Cancer   | 9009/DELNP/2013   | 17-10-2013   |   315126 | 28-06-2019   | MERCK PATENT GMBH                                                   |
|    349 | Cancer   | 695/MUMNP/2012    | 19-03-2012   |   315490 | 03-07-2019   | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA                         |
|    350 | Cancer   | 1413/DELNP/2011   | 25-02-2011   |   315927 | 12-07-2019   | THE JOHNS HOPKINS UNIVERSITY                                        |
|    351 | Cancer   | 7144/DELNP/2009   | 05-11-2009   |   316169 | 16-07-2019   | ZHE JIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY        |
|    352 | Cancer   | 3233/CHE/2012     | 07-08-2012   |   316287 | 17-07-2019   | MARY ANNE PREETHA. K                                                |
|    353 | Cancer   | 464/DELNP/2013    | 15-01-2013   |   316498 | 19-07-2019   | LEAD DISCOVERY CENTER GMBH                                          |
|    354 | Cancer   | 7246/CHENP/2012   | 21-08-2012   |   317217 | 31-07-2019   | ONCOTHERAPY SCIENCE INC.                                            |
|    355 | Cancer   | 2971/CHENP/2011   | 02-05-2011   |   317319 | 31-07-2019   | MOLECULAR PARTNERS AG                                               |
|    356 | Cancer   | 5307/CHENP/2014   | 10-07-2014   |   317533 | 02-08-2019   | BIONEER CORPORATION                                                 |
|    357 | Cancer   | 201817045551      | 03-12-2018   |   317959 | 08-08-2019   | CELLIX BIO PRIVATE LIMITED                                          |

|   358. | Cancer   | 3347/KOLNP/2015   | 12-10-2015   |   318078 | 13-08-2019   | CELON PHARMA S.A.                                                             |
|--------|----------|-------------------|--------------|----------|--------------|-------------------------------------------------------------------------------|
|    359 | Cancer   | 1705/MUMNP/2011   | 17-08-2011   |   318088 | 13-08-2019   | JANSSEN PHARMACEUTICA NV                                                      |
|    360 | Cancer   | 916/DEL/2011      | 31-03-2011   |   318680 | 22-08-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                   |
|    361 | Cancer   | 3619/DEL/2013     | 12-12-2013   |   318742 | 22-08-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                   |
|    362 | Cancer   | 10593/DELNP/2012  | 05-12-2012   |   319024 | 26-08-2019   | FACTOR THERAPEUTICS LIMITED                                                   |
|    363 | Cancer   | 6634/CHENP/2011   | 15-09-2011   |   319340 | 29-08-2019   | ONCOTHERAPY SCIENCE, INC.                                                     |
|    364 | Cancer   | 685/CHENP/2010    | 04-02-2010   |   319633 | 31-08-2019   | OHIO UNIVERSITY                                                               |
|    365 | Cancer   | 6170/DELNP/2012   | 11-07-2012   |   319697 | 03-09-2019   | CANCER RESEARCH TECHNOLOGY LIMITED                                            |
|    366 | Cancer   | 2443/DEL/2013     | 19-08-2013   |   319784 | 04-09-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                   |
|    367 | Cancer   | 854/KOLNP/2013    | 25-03-2013   |   320534 | 16-09-2019   | MERCK PATENT GMBH                                                             |
|    368 | Cancer   | 5817/DELNP/2012   | 29-06-2012   |   322086 | 30-09-2019   | Fundación Centro Nacional De Investigaciones Oncológicas Carlos III           |
|    369 | Cancer   | 1229/MUMNP/2013   | 22-06-2013   |   322269 | 03-10-2019   | FARBER Boris Slavinovich                                                      |
|    370 | Cancer   | 1142/DEL/2013     | 17-04-2013   |   322330 | 04-10-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                   |
|    371 | Cancer   | 7713/DELNP/2015   | 27-08-2015   |   322435 | 09-10-2019   | EPITHERAPEUTICS APS                                                           |
|    372 | Cancer   | 2958/DEL/2013     | 04-10-2013   |   322488 | 10-10-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                   |
|    373 | Cancer   | 3054/DELNP/2014   | 17-04-2014   |   322892 | 16-10-2019   | UNIVERSITY OF CAPE TOWN                                                       |
|    374 | Cancer   | 1850/KOLNP/2012   | 23-07-2012   |   323381 | 22-10-2019   | ARQULE. INC.                                                                  |
|    375 | Cancer   | 4615/CHENP/2012   | 25-05-2012   |   323803 | 28-10-2019   | CENTRO DE IMMUNOLOGIA MOLECULAR                                               |
|    376 | Cancer   | 201647019432      | 06-06-2016   |   323906 | 29-10-2019   | ALMAC DISCOVERY LIMITED                                                       |
|    377 | Cancer   | 693/DELNP/2014    | 29-01-2014   |   324551 | 06-11-2019   | ALFASIGMA S.P.A.                                                              |
|    378 | Cancer   | 3038/KOLNP/2011   | 18-07-2011   |   324667 | 07-11-2019   | MED-LIFE DISCOVERIES LP                                                       |
|    379 | Cancer   | 978/KOL/2015      | 14-09-2015   |   324974 | 13-11-2019   | GUPTA, Parna                                                                  |
|    380 | Cancer   | 2220/DEL/2010     | 17-09-2010   |   325490 | 21-11-2019   | LOVELY PROFESSIONAL UNIVERSITY                                                |
|    381 | Cancer   | 683/DEL/2010      | 22-03-2010   |   325499 | 21-11-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                   |
|    382 | Cancer   | 8354/DELNP/2011   | 28-10-2011   |   325574 | 22-11-2019   | BAYER PHARMA AKTIENGESELLSCHAFT                                               |
|    383 | Cancer   | 7054/DELNP/2009   | 03-11-2009   |   325618 | 22-11-2019   | GE HEALTHCARE AS                                                              |
|    384 | Cancer   | 201647039641      | 21-11-2016   |   325746 | 25-11-2019   | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD |
|    385 | Cancer   | 1627/MUMNP/2015   | 22-06-2015   |   326021 | 27-11-2019   | RUPRECHT- KARLS- UNIVERSITÄT HEIDELBERG                                       |
|    386 | Cancer   | 10575/DELNP/2013  | 09-12-2013   |   326173 | 28-11-2019   | THE REGENTS OF THE UNIVERSITY OF MICHIGAN                                     |
|    387 | Cancer   | 6905/DELNP/2012   | 07-08-2012   |   326214 | 28-11-2019   | IMMUNOGEN INC.                                                                |
|    388 | Cancer   | 9059/CHENP/2013   | 12-11-2013   |   326530 | 02-12-2019   | THE REGENTS OF THE UNIVERSITY OF MICHIGAN                                     |
|    389 | Cancer   | 3136/KOLNP/2013   | 24-10-2013   |   326801 | 04-12-2019   | NEWLINK GENETICS CORPORATION                                                  |
|    390 | Cancer   | 4088/DELNP/2013   | 07-05-2013   |   327502 | 16-12-2019   | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA                                |

|   391. | Cancer                                  | 4127/DELNP/2013       | 08-05-2013   |   327749 | 19-12-2019   | JINAN UNIVERSITY                                                        |
|--------|-----------------------------------------|-----------------------|--------------|----------|--------------|-------------------------------------------------------------------------|
|    392 | Cancer                                  | 4310/CHENP/2014       | 11-06-2014   |   327756 | 19-12-2019   | BAYER PHARMA AKTIENGESELLSCHAFT                                         |
|    393 | Cancer                                  | 408/MUMNP/2015        | 25-02-2015   |   328158 | 26-12-2019   | Izumi Technology, LLC                                                   |
|    394 | Cancer                                  | 24/CHE/2012           | 02-01-2012   |   328222 | 26-12-2019   | AMRITA VISHWA VIDYAPEETHAM                                              |
|    395 | Cancer                                  | 3238/DELNP/2013       | 11-04-2013   |   328337 | 27-12-2019   | GRUPO EMPRESARIAL DE PRODUCCIONES BIOFARMACEUTICAS Y QUIMICAS           |
|    396 | Cancer                                  | 3764/CHE/2010         | 09-12-2010   |   328417 | 30-12-2019   | KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LIMITED                     |
|    397 | Cancer                                  | 1321/DEL/2007         | 19-06-2007   |   328622 | 31-12-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                             |
|    398 | Cancer                                  | 1525/KOLNP/2013       | 16-05-2013   |   329180 | 09-01-2020   | ADAMED SP. Z O.O.                                                       |
|    399 | Cancer                                  | 1524/KOLNP/2013       | 16-05-2013   |   329182 | 09-01-2020   | Adamed sp. z o.o.                                                       |
|    400 | Cancer                                  | 3795/KOLNP/2012       | 04-12-2012   |   329724 | 20-01-2020   | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
|    401 | Cancer                                  | 201611029526          | 30-08-2016   |   329756 | 21-01-2020   | JAMIA HAMDARD UNIVERSITY                                                |
|    402 | Cancer                                  | 1536/KOLNP/2012       | 22-06-2012   |   330032 | 23-01-2020   | ALETHIA BIOTHERAPEUTICS INC.                                            |
|    403 | Cancer,Cardiovascular diseases          | 2291/CHENP/2004       | 11-10-2004   |   218783 | 16-04-2008   | SCHERING CORPORATION                                                    |
|    404 | Cancer,Cardiovascular diseases          | 1893/KOLNP/2004       | 09-12-2004   |   229473 | 18-02-2009   | BANYU PHARMACEUTICAL CO. LTD.                                           |
|    405 | Cancer,Cardiovascular diseases          | IN/PCT/2002/00331/MUM | 19-03-2002   |   236620 | 12-11-2009   | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT                                |
|    406 | Cancer,Cardiovascular diseases          | 1416/CHENP/2007       | 05-04-2007   |   242334 | 24-08-2010   | SCHERING CORPORATION                                                    |
|    407 | Cancer,Cardiovascular diseases          | 4674/DELNP/2009       | 17-07-2009   |   270342 | 14-12-2015   | MSD ITALIA S.R.L                                                        |
|    408 | Cancer,Cardiovascular diseases          | 9948/DELNP/2007       | 20-12-2007   |   278662 | 28-12-2016   | ARCADIA BIOSCIENCES, INC.                                               |
|    409 | Cancer,Cardiovascular diseases          | 8150/DELNP/2008       | 29-09-2008   |   288260 | 11-10-2017   | MSD ITALIA S.R.L                                                        |
|    410 | Cancer,Cardiovascular diseases,Diabetes | 246/DEL/2004          | 20-02-2004   |   237915 | 12-01-2010   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH                           |
|    411 | Cancer,Cardiovascular diseases,Diabetes | 658/DELNP/2008        | 24-01-2008   |   271005 | 29-01-2016   | F.HOFFMANN-LA ROCHE AG                                                  |
|    412 | Cancer,Cardiovascular diseases,Diabetes | 2344/DEL/2009         | 13-11-2009   |   272087 | 16-03-2016   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                             |
|    413 | Cancer,Cardiovascular diseases,Diabetes | 9794/DELNP/2008       | 25-11-2008   |   279391 | 19-01-2017   | MSD ITALIA S.R.L                                                        |
|    414 | Cardiovascular diseases                 | 1615/DELNP/2005       | 20-04-2005   |   216510 | 13-03-2008   | PFIZER PRODUCTS, INC.,                                                  |

|   415. | Cardiovascular diseases   | 1057/DELNP/2004       | 20-04-2004   |   217951 | 31-03-2008   | BORYUNG PHARMACEUTICAL CO., LTD.             |
|--------|---------------------------|-----------------------|--------------|----------|--------------|----------------------------------------------|
|    416 | Cardiovascular diseases   | IN/PCT/2001/29/CHE    | 08-01-2001   |   223136 | 04-09-2008   | SANOFI-AVENTIS DEUTSCHLAND GMBH              |
|    417 | Cardiovascular diseases   | IN/PCT/2002/634/CHE   | 30-04-2002   |   223626 | 19-09-2008   | SANOFI-AVENTIS DEUTSCHLAND GmbH              |
|    418 | Cardiovascular diseases   | IN/PCT/2002/125/KOL   | 25-01-2002   |   225461 | 12-11-2008   | BANYU PHARMACEUTICAL CO. LTD                 |
|    419 | Cardiovascular diseases   | 1102/CHENP/2004       | 18-05-2004   |   226359 | 17-12-2008   | SANOFI-AVENTIS DEUTSCHLAND GmbH              |
|    420 | Cardiovascular diseases   | 3047/CHENP/2005       | 18-11-2005   |   229118 | 13-02-2009   | SANOFI-AVENTIS DEUTSCHLAND GmbH              |
|    421 | Cardiovascular diseases   | IN/PCT/2001/00822/DEL | 14-09-2001   |   231777 | 09-03-2009   | THE PROCTER & GAMBLE COMPANY                 |
|    422 | Cardiovascular diseases   | 1217/DEL/1999         | 10-09-1999   |   232497 | 17-03-2009   | PFIZER PRODUCTS, INC.                        |
|    423 | Cardiovascular diseases   | 1213/DEL/1999         | 10-09-1999   |   232982 | 24-03-2009   | PFIZER PRODUCTS INC.                         |
|    424 | Cardiovascular diseases   | 3058/CHENP/2005       | 18-11-2005   |   234767 | 15-06-2009   | SANOFI-AVENTIS DEUTSCHLAND GMBH              |
|    425 | Cardiovascular diseases   | 5861/DELNP/2005       | 15-12-2005   |   237432 | 22-12-2009   | GALDERMA RESEARCH & DEVELOPMENT, S.N.C.      |
|    426 | Cardiovascular diseases   | 45/CHE/2007           | 08-01-2007   |   241484 | 07-07-2010   | SUVEN LIFE SCIENCES LIMITED                  |
|    427 | Cardiovascular diseases   | 44/CHE/2007           | 08-01-2007   |   241819 | 27-07-2010   | SUVEN LIFE SCIENCES LIMITED                  |
|    428 | Cardiovascular diseases   | 864/MUM/2005          | 21-07-2005   |   244584 | 13-12-2010   | RELIANCE LIFE SCIENCES PRIVATE LIMITED       |
|    429 | Cardiovascular diseases   | 1221/MUMNP/2008       | 16-06-2008   |   251527 | 21-03-2012   | MOSAMEDIX B.V.                               |
|    430 | Cardiovascular diseases   | 1724/CHENP/2006       | 17-05-2006   |   252367 | 10-05-2012   | NOVARTIS AG                                  |
|    431 | Cardiovascular diseases   | 7175/DELNP/2008       | 22-08-2008   |   257608 | 19-10-2013   | PFIZER PRODUCTS INC                          |
|    432 | Cardiovascular diseases   | 7460/DELNP/2006       | 11-12-2006   |   257611 | 21-10-2013   | LABORATOIRES SERONO S.A.                     |
|    433 | Cardiovascular diseases   | 3622/DELNP/2007       | 15-05-2007   |   263465 | 30-10-2014   | PIRAMED LIMITED                              |
|    434 | Cardiovascular diseases   | 9720/DELNP/2008       | 21-11-2008   |   264770 | 20-01-2015   | F. HOFFMANN-LA ROCHE AG                      |
|    435 | Cardiovascular diseases   | 465/MUMNP/2008        | 12-03-2008   |   268278 | 25-08-2015   | RADIORX, INC; C/O INTERWEST VENTURE PARTNERS |
|    436 | Cardiovascular diseases   | 1844/KOLNP/2008       | 07-05-2008   |   272457 | 01-04-2016   | PORTOLA PHARMACEUTICALS, INC.                |
|    437 | Cardiovascular diseases   | 3272/CHENP/2008       | 26-06-2008   |   275013 | 18-08-2016   | GTX, INC.                                    |

|   438. | Cardiovascular diseases          | 1451/DELNP/2008   | 20-02-2008   |   276310 | 14-10-2016   | INVENTIVA                            |
|--------|----------------------------------|-------------------|--------------|----------|--------------|--------------------------------------|
|    439 | Cardiovascular diseases          | 2433/CHE/2007     | 26-10-2007   |   283443 | 22-05-2017   | SUVEN LIFE SCIENCES LIMITED          |
|    440 | Cardiovascular diseases          | 3892/CHENP/2010   | 22-06-2010   |   284208 | 14-06-2017   | ACTELION PHARMACEUTICALS LTD.        |
|    441 | Cardiovascular diseases          | 940/CHE/2007      | 03-05-2007   |   285812 | 28-07-2017   | SUVEN LIFE SCIENCES LIMITED          |
|    442 | Cardiovascular diseases          | 5207/KOLNP/2011   | 27-12-2011   |   286908 | 31-08-2017   | GILEAD SCIENCES, INC.                |
|    443 | Cardiovascular diseases          | 6652/DELNP/2010   | 21-09-2010   |   290037 | 28-11-2017   | NEXGENIX PHARMACEUTICALS             |
|    444 | Cardiovascular diseases          | 7/CHENP/2012      | 02-01-2012   |   298025 | 25-06-2018   | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. |
|    445 | Cardiovascular diseases          | 9355/CHENP/2011   | 14-12-2011   |   298854 | 16-07-2018   | NERVIANO MEDICAL SCIENCES S.RL       |
|    446 | Cardiovascular diseases          | 5473/CHENP/2012   | 22-06-2012   |   301989 | 09-10-2018   | F. HOFFMANN-LA ROCHE AG              |
|    447 | Cardiovascular diseases          | 3977/CHENP/2013   | 21-05-2013   |   303402 | 26-11-2018   | LG CHEM, LTD.                        |
|    448 | Cardiovascular diseases          | 2642/DELNP/2009   | 22-04-2009   |   305007 | 27-12-2018   | BAYER INTELLECTUAL PROPERTYGMBH      |
|    449 | Cardiovascular diseases          | 4021/KOLNP/2012   | 18-12-2012   |   307592 | 19-02-2019   | GILEAD SCIENCES, INC.                |
|    450 | Cardiovascular diseases          | 9136/CHENP/2014   | 18-12-2014   |   308114 | 26-02-2019   | MERCK SHARP & DOHME CORP.            |
|    451 | Cardiovascular diseases          | 1837/KOLNP/2012   | 20-07-2012   |   309894 | 25-03-2019   | ARRAY BIOPHARMA INC.                 |
|    452 | Cardiovascular diseases          | 7885/DELNP/2014   | 22-09-2014   |   313804 | 06-06-2019   | ASD THERAPEUTICS PARTNERS LLC        |
|    453 | Cardiovascular diseases          | 33/DELNP/2011     | 03-01-2011   |   317748 | 06-08-2019   | SIRTRIS PHARMACEUTICALS, INC.        |
|    454 | Cardiovascular diseases          | 8599/DELNP/2011   | 04-11-2011   |   322388 | 07-10-2019   | Schering Corporation                 |
|    455 | Cardiovascular diseases          | 6490/CHENP/2012   | 23-07-2012   |   324083 | 31-10-2019   | REGENERON PHARMACEUTICALS, INC.      |
|    456 | Cardiovascular diseases,Diabetes | 4531/DELNP/2006   | 04-08-2006   |   256706 | 19-07-2013   | ASTRAZENECA PHARMACEUTICALS LP       |
|    457 | Cardiovascular diseases,Diabetes | 6776/DELNP/2007   | 31-08-2007   |   258367 | 02-01-2014   | AMYLIN PHARMACEUTICALS LLC.          |
|    458 | Cardiovascular diseases,Diabetes | 6162/DELNP/2009   | 25-09-2009   |   273280 | 30-05-2016   | PFIZER INC                           |
|    459 | Cardiovascular diseases,Diabetes | 5111/DELNP/2009   | 07-08-2009   |   274006 | 05-07-2016   | PFIZER INC                           |

|   460. | Cardiovascular diseases,Diabetes   | 8949/DELNP/2010       | 14-12-2010   |   294191 | 13-03-2018   | XIGEN INFLAMMATION LTD.                        |
|--------|------------------------------------|-----------------------|--------------|----------|--------------|------------------------------------------------|
|    461 | Cardiovascular diseases,Diabetes   | 2671/CHE/2010         | 13-09-2010   |   299037 | 20-07-2018   | IMPETIS BIOSCIENCES LIMITED.                   |
|    462 | Cardiovascular diseases,Diabetes   | 6502/DELNP/2014       | 01-08-2014   |   327378 | 13-12-2019   | NOVARTIS AG                                    |
|    463 | Diabetes                           | 1150/MAS/1996         | 01-07-1996   |   202816 | 30-10-2006   | DR. REDDY'S LABORATORIES LTD                   |
|    464 | Diabetes                           | IN/PCT/2002/00433/MUM | 09-04-2002   |   205147 | 15-03-2007   | BRISTOL-MYERS SQUIBB CO.                       |
|    465 | Diabetes                           | 1150/CHENP/2003       | 24-07-2003   |   207007 | 16-05-2007   | M/S. SCHERING CORPORATION                      |
|    466 | Diabetes                           | 843/CAL/1999          | 12-10-1999   |   208773 | 09-08-2007   | TORRENT PHARAMACEUTICALS LTD                   |
|    467 | Diabetes                           | 1416/CHENP/2004       | 23-06-2004   |   209390 | 28-08-2007   | F. HOFFMANN-LA ROCHE AG                        |
|    468 | Diabetes                           | 2502/MAS/1997         | 03-11-1997   |   209534 | 04-09-2007   | NOVARTIS AG                                    |
|    469 | Diabetes                           | 26/CHENP/2004         | 06-01-2004   |   209816 | 06-09-2007   | MERCK & CO. INC                                |
|    470 | Diabetes                           | 2004/CHENP/2004       | 08-09-2004   |   211872 | 13-11-2007   | TAISHO PHARMACEUTICAL CO., LTD                 |
|    471 | Diabetes                           | 11/CAL/2000           | 10-01-2000   |   212114 | 20-11-2007   | SAJAN KUMAR SINGHANIA                          |
|    472 | Diabetes                           | 0561/DEL/1999         | 13-04-1999   |   213215 | 24-12-2007   | Dr. PUSHPA KHANNA                              |
|    473 | Diabetes                           | 874/KOLNP/2003        | 08-07-2003   |   214242 | 07-02-2008   | GLAXO GROUP LIMITED                            |
|    474 | Diabetes                           | 604/CAL/2001          | 19-10-2001   |   214276 | 07-02-2008   | TORRENT PHARMACEUTICALS LTD                    |
|    475 | Diabetes                           | 170/CHE/2004          | 01-03-2004   |   214342 | 11-02-2008   | THE MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES |
|    476 | Diabetes                           | 615/KOLNP/2004        | 12-05-2004   |   214989 | 20-02-2008   | ASTELLAS PHARMA INC                            |
|    477 | Diabetes                           | 1775/KOLNP/2004       | 23-11-2004   |   215535 | 27-02-2008   | ASTELLAS PHARMA INC                            |
|    478 | Diabetes                           | 475/DEL/2000          | 01-05-2000   |   216784 | 19-03-2008   | INDIAN COUNCIL OF MEDICAL RESEARCH             |
|    479 | Diabetes                           | 863/CHENP/2004        | 23-04-2004   |   218264 | 31-03-2008   | F. HOFFMANN-LA ROCHE AG                        |
|    480 | Diabetes                           | 1011/CHENP/2005       | 24-05-2005   |   218522 | 02-04-2008   | F. HOFFMANN-LA ROCHE AG                        |
|    481 | Diabetes                           | 795/KOLNP/2003        | 19-06-2003   |   219078 | 23-04-2008   | VERTEX PHARMACEUTICALS INCORPORATED            |
|    482 | Diabetes                           | 553/CHENP/2005        | 05-04-2005   |   219135 | 25-04-2008   | F. HOFFMANN-LA ROCHE AG                        |
|    483 | Diabetes                           | 963/CHENP/2005        | 18-05-2005   |   219148 | 25-04-2008   | MERCK & CO. INC                                |
|    484 | Diabetes                           | 54/CHENP/2005         | 24-01-2005   |   221266 | 20-06-2008   | OHIO UNIVERSITY                                |
|    485 | Diabetes                           | 792/KOLNP/2005        | 03-05-2005   |   221582 | 25-06-2008   | SHENZHEN CHIPSCREEN BIOSCIENCES LTD.           |
|    486 | Diabetes                           | 1150/KOLNP/2005       | 15-06-2005   |   222137 | 23-07-2008   | ARENA PHARMACEUTICALS INC.                     |
|    487 | Diabetes                           | 00774/DELNP/2004      | 25-03-2004   |   222813 | 25-08-2008   | BAYER PHARMACEUTICALS CORPORATION              |
|    488 | Diabetes                           | 1346/MAS/1998         | 19-06-1998   |   223529 | 12-09-2008   | SANOFI-AVENTIS DEUTSCHLAND GMBH                |
|    489 | Diabetes                           | 2392/DELNP/2005       | 06-06-2005   |   224706 | 22-10-2008   | MERCK & CO., INC.                              |
|    490 | Diabetes                           | IN/PCT/2002/604/CHE   | 23-04-2002   |   224856 | 23-10-2008   | SANOFI-AVENTIS DEUTSCHLAND GMBH                |

|   491. | Diabetes   | 546/KOLNP/2003        | 30-04-2003   |   225218 | 05-11-2008   | ELI LILLY AND COMPANY                                           |
|--------|------------|-----------------------|--------------|----------|--------------|-----------------------------------------------------------------|
|    492 | Diabetes   | 794/KOLNP/2003        | 19-06-2003   |   225992 | 03-12-2008   | VERTEX PHARMACEUTICALS INCORPORATED                             |
|    493 | Diabetes   | 1808/DELNP/2004       | 24-06-2004   |   226041 | 05-12-2008   | OSI PHARMACEUTICALS, INC                                        |
|    494 | Diabetes   | 525/CHENP/2005        | 01-04-2005   |   226650 | 23-12-2008   | NOVARTIS AG                                                     |
|    495 | Diabetes   | 1773/CHENP/2003       | 11-11-2003   |   227050 | 31-12-2008   | BIOVITRUM AB (PUBL)                                             |
|    496 | Diabetes   | 566/DELNP/2005        | 14-02-2005   |   227717 | 19-01-2009   | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG.                      |
|    497 | Diabetes   | 285/KOLNP/2003        | 07-03-2003   |   228090 | 28-01-2009   | AVONTEC GMBH                                                    |
|    498 | Diabetes   | 796/KOLNP/2003        | 19-06-2003   |   228789 | 11-02-2009   | VERTEX PHARMACEUTICALS INCORPORATED                             |
|    499 | Diabetes   | 2787/CHENP/2004       | 09-12-2004   |   229003 | 13-02-2009   | MERCK & CO., INC.                                               |
|    500 | Diabetes   | 1162/CHENP/2004       | 27-05-2004   |   229217 | 13-02-2009   | THERACOS  INC                                              |
|    501 | Diabetes   | 2530/DELNP/2004       | 31-08-2004   |   230517 | 27-02-2009   | WARNER-LAMBERT COMPANY                                          |
|    502 | Diabetes   | 650/CHENP/2004        | 29-03-2004   |   230522 | 27-02-2009   | AUSTRALIAN BIOMEDICAL COMPANY PTY LTD                           |
|    503 | Diabetes   | 878/DEL/1999          | 15-06-1999   |   230589 | 27-02-2009   | PFIZER PRODUCTS, INC.                                           |
|    504 | Diabetes   | 838/DEL/2003          | 25-06-2003   |   230753 | 27-02-2009   | INDIAN COUNCIL OF MEDICAL RESEARCH                              |
|    505 | Diabetes   | 876/DEL/1999          | 15-06-1999   |   230955 | 28-02-2009   | PFIZER PRODUCTS, INC.                                           |
|    506 | Diabetes   | IN/PCT/2000/457/KOL   | 31-10-2000   |   231439 | 04-03-2009   | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC.               |
|    507 | Diabetes   | IN/PCT/2002/00773/MUM | 12-06-2002   |   232300 | 16-03-2009   | METABASIS THERAPEUTICS, INC.                                    |
|    508 | Diabetes   | 2560/CHENP/2005       | 06-10-2005   |   234300 | 19-05-2009   | NOVARTIS AG                                                     |
|    509 | Diabetes   | 4659/DELNP/2005       | 13-10-2005   |   235086 | 24-06-2009   | ASTELLAS PHARMA INC.,                                           |
|    510 | Diabetes   | 293/KOLNP/2003        | 10-03-2003   |   235831 | 02-09-2009   | VERTEX PHARMACEUTICALS INCORPORATED                             |
|    511 | Diabetes   | 1370/KOLNP/2005       | 15-07-2005   |   235914 | 03-09-2009   | ARENA PHARMACEUTICALS, INC.                                     |
|    512 | Diabetes   | 60/KOLNP/2003         | 16-01-2003   |   235972 | 10-09-2009   | ARRAY BIOPHARMA, INC.                                           |
|    513 | Diabetes   | 1710/DELNP/2005       | 27-04-2005   |   236232 | 12-10-2009   | MERCK & CO., INC.                                               |
|    514 | Diabetes   | 5539/DELNP/2005       | 30-11-2005   |   237436 | 22-12-2009   | F. HOFFMANN-LA ROCHE AG                                         |
|    515 | Diabetes   | 2384/DELNP/2005       | 03-06-2005   |   237983 | 15-01-2010   | INSTITUTE OF MATERIA MEDICA,CHINESE ACADEMY OF MEDICAL SCIENCES |
|    516 | Diabetes   | 5915/DELNP/2005       | 19-12-2005   |   238463 | 05-02-2010   | F. HOFFMANN-LA ROCHE AG                                         |
|    517 | Diabetes   | 1966/KOLNP/2005       | 05-10-2005   |   238998 | 03-03-2010   | ASTELLAS PHARMA INC.                                            |
|    518 | Diabetes   | 122/CHE/2004          | 18-02-2004   |   239060 | 04-03-2010   | LANSON BIO TECH PRIVATE LIMITED                                 |
|    519 | Diabetes   | 1537/DELNP/2006       | 22-03-2006   |   239481 | 23-03-2010   | SOLVAY PHARMACEUTICALS GMBH                                     |
|    520 | Diabetes   | 869/KOLNP/2003        | 04-07-2003   |   239551 | 24-03-2010   | VERTEX PHARMACEUTICALS INCORPORATED                             |
|    521 | Diabetes   | 352/CHE/2004          | 19-04-2004   |   239944 | 13-04-2010   | BIOCON LIMITED.                                                 |
|    522 | Diabetes   | 3866/DELNP/2005       | 30-08-2005   |   240889 | 08-06-2010   | BANYU PHARMACEUTICAL CO., LTD.                                  |

|   523. | Diabetes   | 797/DELNP/2006        | 16-02-2006   |   241200 | 23-06-2010   | AYURVEDIC-LIFE INTERNATIONAL, LLC.             |
|--------|------------|-----------------------|--------------|----------|--------------|------------------------------------------------|
|    524 | Diabetes   | 960/CHE/2007          | 07-05-2007   |   241327 | 29-06-2010   | AVESTHAGEN LIMITED                             |
|    525 | Diabetes   | IN/PCT/2002/00588/DEL | 10-06-2002   |   241773 | 24-07-2010   | PFIZER PRODUCTS INC.                           |
|    526 | Diabetes   | 2090/DEL/1998         | 20-07-1998   |   241782 | 24-07-2010   | SMITHKLINE BEECHAM P.L.C                       |
|    527 | Diabetes   | 797/KOLNP/2003        | 19-06-2003   |   241851 | 28-07-2010   | VERTEX PHARMACEUTICALS INCORPORATED            |
|    528 | Diabetes   | 6078/DELNP/2005       | 26-12-2005   |   242032 | 06-08-2010   | F. HOFFMANN-LA ROCHE AG                        |
|    529 | Diabetes   | 2785/KOLNP/2006       | 25-09-2006   |   242537 | 31-08-2010   | TAKEDA PHARMACEUTICAL COMPANY LIMITED          |
|    530 | Diabetes   | 405/MUM/2004          | 01-04-2004   |   245326 | 13-01-2011   | NATIONAL CENTRE FOR CELL SCIENCE               |
|    531 | Diabetes   | 108/DELNP/2005        | 12-01-2005   |   245350 | 14-01-2011   | ASTELLAS PHARMA INC.                           |
|    532 | Diabetes   | 4869/DELNP/2005       | 24-10-2005   |   246313 | 24-02-2011   | MERCK SHARP& DOHME CORP.                       |
|    533 | Diabetes   | 836/MUM/2003          | 21-08-2003   |   247484 | 12-04-2011   | RPG LIFE SCIENCES LIMITED                      |
|    534 | Diabetes   | 2482/CHENP/2006       | 06-07-2006   |   247551 | 19-04-2011   | ACCESS BIOSCIENCE CJSC                         |
|    535 | Diabetes   | 155/MUM/2008          | 23-01-2008   |   247558 | 20-04-2011   | RAMCHANDRA SADASHIV DAMLE                      |
|    536 | Diabetes   | 2026/DEL/2004         | 15-10-2004   |   247797 | 20-05-2011   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH    |
|    537 | Diabetes   | 1643/DELNP/2005       | 21-04-2005   |   248867 | 02-09-2011   | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG.     |
|    538 | Diabetes   | 828/CAL/1999          | 06-10-1999   |   250728 | 23-01-2012   | TORRENT PHARMACEUTICALS LTD.                   |
|    539 | Diabetes   | 901/MUM/2004          | 20-08-2004   |   250735 | 23-01-2012   | CADILA HEALTHCARE LIMITED                      |
|    540 | Diabetes   | 5055/DELNP/2006       | 01-09-2006   |   250758 | 24-01-2012   | F. HOFFMANN-LA ROCHE AG                        |
|    541 | Diabetes   | 7590/DELNP/2006       | 15-12-2006   |   252518 | 21-05-2012   | MERCK SHARP & DOHME CORP.                      |
|    542 | Diabetes   | 2081/MUMNP/2007       | 07-12-2007   |   252532 | 21-05-2012   | CUREDM GROUP HOLDINGS, LLC                     |
|    543 | Diabetes   | 2409/KOLNP/2007       | 29-06-2007   |   253794 | 24-08-2012   | DOMANTIS LIMITED                               |
|    544 | Diabetes   | 2157/CHENP/2004       | 28-09-2004   |   254167 | 25-09-2012   | NOVARTIS AG                                    |
|    545 | Diabetes   | 372/MUMNP/2008        | 27-02-2008   |   254746 | 14-12-2012   | AETERNA ZENTARIS GMBH                          |
|    546 | Diabetes   | 611/DEL/2006          | 08-03-2006   |   258216 | 18-12-2013   | Council of Scientific and Industrial Research. |
|    547 | Diabetes   | 609/MUMNP/2009        | 27-03-2009   |   258913 | 14-02-2014   | LEXICON PHARMACEUTICALS INC.                   |
|    548 | Diabetes   | 786/MUMNP/2009        | 22-04-2009   |   259851 | 28-03-2014   | JANSSEN PHARMACEUTICA NV                       |
|    549 | Diabetes   | 7775/DELNP/2007       | 10-10-2007   |   260345 | 24-04-2014   | F.HOFFMANN-LA ROCHE AG                         |
|    550 | Diabetes   | 2025/DELNP/2008       | 10-03-2008   |   260707 | 18-05-2014   | F.HOFFMAN-LA ROCHE AG                          |
|    551 | Diabetes   | 71/KOLNP/2006         | 09-01-2006   |   261954 | 24-07-2014   | ARENA PHARMACEUTICALS INC.                     |
|    552 | Diabetes   | 3409/KOLNP/2008       | 21-08-2008   |   263867 | 25-11-2014   | ELAN PHARMACEUTICALS, INC.                     |
|    553 | Diabetes   | 2876/DELNP/2008       | 07-04-2008   |   264919 | 29-01-2015   | OTSUKA PHARMACEUTICAL CO.,LTD                  |
|    554 | Diabetes   | 4694/CHENP/2008       | 05-09-2008   |   265228 | 13-02-2015   | SCHERING CORPORATION                           |
|    555 | Diabetes   | 45/KOLNP/2009         | 05-01-2009   |   267824 | 31-07-2015   | TAKEDA PHARMACEUTICAL COMPANY LIMITED          |

|   556. | Diabetes   | 8561/DELNP/2008   | 13-10-2008   |   269610 | 29-10-2015   | ASTRAZENECA AB                                |
|--------|------------|-------------------|--------------|----------|--------------|-----------------------------------------------|
|    557 | Diabetes   | 2273/DELNP/2003   | 26-12-2003   |   272385 | 31-03-2016   | WELLSTAT THERAPEUTICS CORPORATION             |
|    558 | Diabetes   | 2271/KOLNP/2009   | 18-06-2009   |   272993 | 09-05-2016   | CYMABAY THERAPEUTICS,INC.                     |
|    559 | Diabetes   | 784/MUMNP/2009    | 22-04-2009   |   273408 | 03-06-2016   | JANSSEN PHARMACEUTICA NV                      |
|    560 | Diabetes   | 3156/DELNP/2008   | 17-04-2008   |   275190 | 26-08-2016   | MERCK SHARP & DOHME CORPORATION           |
|    561 | Diabetes   | 2060/DELNP/2010   | 23-03-2010   |   276203 | 04-10-2016   | ARRAY BIOPHARMA INC.                          |
|    562 | Diabetes   | 10/DEL/2009       | 05-01-2009   |   277832 | 01-12-2016   | KAKATIYA UNIVERSITY                           |
|    563 | Diabetes   | 6517/DELNP/2010   | 16-09-2010   |   277836 | 01-12-2016   | F. HOFFMANN-LA ROCHE AG                       |
|    564 | Diabetes   | 4453/KOLNP/2010   | 25-11-2010   |   278436 | 22-12-2016   | MERCK PATENT GMBH                             |
|    565 | Diabetes   | 1572/CHENP/2009   | 20-03-2009   |   278472 | 23-12-2016   | MERCK SHARP & DOHME CORP.,                    |
|    566 | Diabetes   | 4959/CHENP/2007   | 05-11-2007   |   278877 | 02-01-2017   | PRONOVA BIOPHARMA NORGE AS                    |
|    567 | Diabetes   | 313/DEL/2006      | 03-02-2006   |   279549 | 25-01-2017   | COUNCIL OF SCIENTIFIC & INDISTRIAL RESEARCH   |
|    568 | Diabetes   | 1654/DELNP/2007   | 01-03-2007   |   280713 | 27-02-2017   | EMISPHERE TECHNOLOGIES, INC.                  |
|    569 | Diabetes   | 1651/CHE/2007     | 30-07-2007   |   281259 | 10-03-2017   | SAVARIMUTHU IGNACIMUTHU                       |
|    570 | Diabetes   | 7979/DELNP/2008   | 23-09-2008   |   281262 | 10-03-2017   | F.HOFFMANN-LA ROCHE AG                        |
|    571 | Diabetes   | 3681/KOLNP/2010   | 04-10-2010   |   282677 | 21-04-2017   | MERCK PATENT GMBH                             |
|    572 | Diabetes   | 3683/KOLNP/2010   | 04-10-2010   |   283208 | 09-05-2017   | MERCK PATENT GMBH                             |
|    573 | Diabetes   | 3600/CHENP/2009   | 22-06-2009   |   283306 | 15-05-2017   | NOVOZYMES A/S                                 |
|    574 | Diabetes   | 2146/MUMNP/2009   | 17-11-2009   |   284333 | 19-06-2017   | DONG-A ST CO; LTD;                            |
|    575 | Diabetes   | 3940/KOLNP/2010   | 21-10-2010   |   289112 | 02-11-2017   | CYMABAY THERAPEUTICS,INC                      |
|    576 | Diabetes   | 458/DEL/2009      | 09-03-2009   |   289774 | 21-11-2017   | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH |
|    577 | Diabetes   | 762/DELNP/2006    | 15-02-2006   |   290778 | 19-12-2017   | ASKAT INC                                     |
|    578 | Diabetes   | 1411/DELNP/2012   | 15-02-2012   |   293600 | 28-02-2018   | IPSEN PHARMA S.A.S.                           |
|    579 | Diabetes   | 6096/DELNP/2011   | 10-08-2011   |   295733 | 12-04-2018   | TAKEDA PHARMACEUTICAL COMPANY LIMITED         |
|    580 | Diabetes   | 1268/MUMNP/2012   | 22-05-2012   |   296856 | 17-05-2018   | ELI LILLY AND COMPANY                         |
|    581 | Diabetes   | 6966/DELNP/2012   | 08-08-2012   |   296934 | 21-05-2018   | RINAT NEUROSCIENCE CORP.                      |
|    582 | Diabetes   | 2614/MUMNP/2011   | 05-12-2011   |   297769 | 19-06-2018   | ELI LILLY AND COMPANY                         |
|    583 | Diabetes   | 6636/DELNP/2011   | 30-08-2011   |   298245 | 28-06-2018   | VTV THERAPEUTICS LLC                          |
|    584 | Diabetes   | 1825/DELNP/2009   | 19-03-2009   |   300611 | 31-08-2018   | NOVO NORDISK A/S                              |
|    585 | Diabetes   | 726/MUMNP/2013    | 12-04-2013   |   301659 | 28-09-2018   | DAIICHI SANKYO COMPANY LIMITED                |
|    586 | Diabetes   | 4150/KOLNP/2009   | 01-12-2009   |   301942 | 08-10-2018   | ELI LILLY AND COMPANY                         |
|    587 | Diabetes   | 2542/KOLNP/2012   | 06-09-2012   |   302586 | 30-10-2018   | BEIJING DONGFANG BIOTECH CO. LTD.             |
|    588 | Diabetes   | 5628/CHENP/2014   | 21-07-2014   |   305017 | 27-12-2018   | CONNEXIOS LIFE SCIENCES PVT. LTD.             |

|   589. | Diabetes                | 59/MUMNP/2012        | 06-01-2012   |   307742 | 21-02-2019   | Jiangsu Hansoh Pharmaceutical Group Co. Ltd.   |
|--------|-------------------------|----------------------|--------------|----------|--------------|------------------------------------------------|
|    590 | Diabetes                | 10426/CHENP/2012     | 14-12-2012   |   307830 | 22-02-2019   | BETTA PHARMACEUTICALS CO., LTD                 |
|    591 | Diabetes                | 5197/CHENP/2012      | 14-06-2012   |   308218 | 27-02-2019   | Novo Nordisk A/S                               |
|    592 | Diabetes                | 491/KOLNP/2012       | 02-03-2012   |   309945 | 26-03-2019   | BIOENERGENIX                                   |
|    593 | Diabetes                | 201647028442         | 22-08-2016   |   310564 | 29-03-2019   | F. HOFFMANN LA ROCHE AG                        |
|    594 | Diabetes                | 6261/DELNP/2011      | 17-08-2011   |   310982 | 08-04-2019   | TAISHO PHARMACEUTICAL CO., LTD.                |
|    595 | Diabetes                | 4686/DELNP/2011      | 17-06-2011   |   311475 | 23-04-2019   | GH CARE INC. D/B/A ALTUCELL INC.               |
|    596 | Diabetes                | 3783/MUM/2014        | 27-11-2014   |   312245 | 03-05-2019   | NORTH MAHARASHTRA UNIVERSITY                   |
|    597 | Diabetes                | 5993/DELNP/2014      | 17-07-2014   |   315707 | 09-07-2019   | JIANGSU HENGRUI MEDICINE CO. LTD.              |
|    598 | Diabetes                | 8357/DELNP/2012      | 25-09-2012   |   315713 | 09-07-2019   | GLAXOSMITHKLINE LLC                            |
|    599 | Diabetes                | 9759/DELNP/2012      | 09-11-2012   |   319586 | 30-08-2019   | THE UNIVERSITY OF EDINBURGH                    |
|    600 | Diabetes                | 2590/DELNP/2012      | 23-03-2012   |   319776 | 04-09-2019   | THE UNIVERSITY OF EDINBURGH                    |
|    601 | Diabetes                | 5402/DELNP/2014      | 01-07-2014   |   320136 | 09-09-2019   | CISEN PHARMACEUTICAL CO., LTD.                 |
|    602 | Diabetes                | 5627/CHENP/2014      | 21-07-2014   |   320177 | 10-09-2019   | CONNEXIOS LIFE SCIENCES PVT. LTD.              |
|    603 | Diabetes                | 3753/KOLNP/2010      | 07-10-2010   |   320686 | 17-09-2019   | THE UNIVERSITY OF EDINBURGH                    |
|    604 | Diabetes                | 571/CHE/2009         | 13-03-2009   |   321143 | 23-09-2019   | IMPETIS BIOSCIENCES LIMITED.                   |
|    605 | Diabetes                | 6284/DELNP/2013      | 15-07-2013   |   321234 | 24-09-2019   | BIOENERGENIX                                   |
|    606 | Diabetes                | 201647009694         | 21-03-2016   |   322418 | 09-10-2019   | F. HOFFMANN LA ROCHE AG                        |
|    607 | Diabetes                | 3199/DELNP/2013      | 10-04-2013   |   327758 | 19-12-2019   | Aegerion Pharmaceuticals, Inc.                 |
|    608 | Diabetes                | 4654/CHE/2012        | 06-11-2012   |   328742 | 31-12-2019   | KARNATAKA COLLEGE OF PHARMACY                  |
|    609 | Hepatitis C Virus (HCV) | IN/PCT/2002/1553/KOL | 19-12-2002   |   206623 | 03-05-2007   | GLAXOSMITHKLINE BIOLOGICALS S.A.,              |
|    610 | Hepatitis C Virus (HCV) | 856/CAL/1995         | 25-07-1995   |   207398 | 08-06-2007   | CHIRON CORPORATION                             |
|    611 | Hepatitis C Virus (HCV) | 1471/CHENP/2003      | 17-09-2003   |   209780 | 06-09-2007   | M/S. SMITHKLINE BEECHAM BIOLOGICALS S.A        |
|    612 | Hepatitis C Virus (HCV) | 175/KOLNP/2003       | 13-02-2003   |   210092 | 18-09-2007   | GLAXOSMITHKLINE BIOLOGICALS S.A.               |
|    613 | Hepatitis C Virus (HCV) | 724/KOLNP/2005       | 25-04-2005   |   216043 | 06-03-2008   | GLAXO GROUP LIMITED                            |
|    614 | Hepatitis C Virus (HCV) | 719/KOLNP/2005       | 25-04-2005   |   221897 | 09-07-2008   | GLAXO GROUP LIMITED                            |
|    615 | Hepatitis C Virus (HCV) | 1193/DEL/2002        | 27-11-2002   |   223209 | 05-09-2008   | OHARI, VIJAY KUMAR                             |
|    616 | Hepatitis C Virus (HCV) | 1375/DEL/1996        | 21-06-1996   |   223753 | 22-09-2008   | SMITHKLINE BEECHAM BIOLOGICALS S.A.            |
|    617 | Hepatitis C Virus (HCV) | 224/CHE/2004         | 12-03-2004   |   224903 | 24-10-2008   | INDIAN INSTITUTE OF SCIENCE                    |

|   618. | Hepatitis C Virus (HCV)   | 363/KOLNP/2006   | 17-02-2006   |   226766 | 24-12-2008   | RHEIN BIOTECH GESELLSCHAFT FUR NEUE BIOTECHNOLOGISCHE PROZESSE UND PRODUKTE MBH   |
|--------|---------------------------|------------------|--------------|----------|--------------|-----------------------------------------------------------------------------------|
|    619 | Hepatitis C Virus (HCV)   | 2245/DEL/1998    | 31-07-1998   |   231861 | 12-03-2009   | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG.                                        |
|    620 | Hepatitis C Virus (HCV)   | 1658/DEL/1998    | 16-06-1998   |   232446 | 17-03-2009   | HAKIM ABDUL HAMEED, INDIAN                                                        |
|    621 | Hepatitis C Virus (HCV)   | 1756/KOLNP/2005  | 05-09-2005   |   237893 | 12-01-2010   | CAPITALBIO CORPOTION                                                              |
|    622 | Hepatitis C Virus (HCV)   | 2113/MUM/2006    | 22-12-2006   |   240617 | 19-05-2010   | DR. RAJESH SHAH                                                                   |
|    623 | Hepatitis C Virus (HCV)   | 1564/DELNP/2005  | 19-04-2005   |   240734 | 26-05-2010   | INSTITUTE OF IMMUNOLOGY, PLA                                                      |
|    624 | Hepatitis C Virus (HCV)   | 1922/CHENP/2007  | 07-05-2007   |   241755 | 23-07-2010   | SUDERSHAN BIOTECH LTD                                                             |
|    625 | Hepatitis C Virus (HCV)   | 576/DELNP/2005   | 15-02-2005   |   243283 | 01-10-2010   | JAPAN SCIENCES AND TECHNOLOGY AGENCY                                              |
|    626 | Hepatitis C Virus (HCV)   | 4239/DELNP/2005  | 20-09-2005   |   245923 | 07-02-2011   | LORANTIS, LTD                                                                     |
|    627 | Hepatitis C Virus (HCV)   | 6137/DELNP/2006  | 19-10-2006   |   246663 | 09-03-2011   | CELLDEX THERAPEUTICS LIMITED,FORMERLY KNOWNAS LORANTIS,LIMITED                    |
|    628 | Hepatitis C Virus (HCV)   | 858/DEL/2004     | 11-05-2004   |   247615 | 27-04-2011   | OHARI, VIJAY KUMAR                                                                |
|    629 | Hepatitis C Virus (HCV)   | 51/DELNP/2007    | 02-01-2007   |   248207 | 28-06-2011   | CHENGDU INSTITUTE OF BIOLOGICAL PRODUCTS                                          |
|    630 | Hepatitis C Virus (HCV)   | 3149/DELNP/2007  | 26-04-2007   |   254551 | 17-11-2012   | IDENIX PHARMACEUTICALS, INC.                                                      |
|    631 | Hepatitis C Virus (HCV)   | 2437/DEL/2008    | 24-10-2008   |   272351 | 30-03-2016   | PANACEA BIOTEC LIMITED                                                            |
|    632 | Hepatitis C Virus (HCV)   | 2438/DEL/2008    | 24-10-2008   |   272364 | 30-03-2016   | PANACEA BIOTEC LIMITED                                                            |
|    633 | Hepatitis C Virus (HCV)   | 3739/CHENP/2009  | 26-06-2009   |   276267 | 07-10-2016   | DOBEEL CO. LTD.                                                                   |
|    634 | Hepatitis C Virus (HCV)   | 1449/MUMNP/2010  | 05-07-2010   |   276854 | 02-11-2016   | RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG                                             |
|    635 | Hepatitis C Virus (HCV)   | 889/MUMNP/2010   | 29-04-2010   |   284222 | 14-06-2017   | SABELL CORPORATION                                                                |
|    636 | Hepatitis C Virus (HCV)   | 503/DELNP/2010   | 22-01-2010   |   286717 | 28-08-2017   | Arrowhead Pharmaceuticals, Inc.                                                   |
|    637 | Hepatitis C Virus (HCV)   | 6674/DELNP/2007  | 29-08-2007   |   287874 | 28-09-2017   | BOEHRINGER INGELHEIM INTERNATIONAL GMBH.                                          |
|    638 | Hepatitis C Virus (HCV)   | 131/KOLNP/2009   | 12-01-2009   |   288805 | 27-10-2017   | GLAXOSMITHKLINE BIOLOGICALS S.A.                                                  |
|    639 | Hepatitis C Virus (HCV)   | 190/DEL/2008     | 23-01-2008   |   290618 | 14-12-2017   | DEPARTMENT OF BIOTECHNOLOGY                                                       |

|   640. | Hepatitis C Virus (HCV)   | 8039/DELNP/2010       | 15-11-2010   |   296177 | 26-04-2018   | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMANSERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION   |
|--------|---------------------------|-----------------------|--------------|----------|--------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    641 | Hepatitis C Virus (HCV)   | 6860/DELNP/2011       | 08-09-2011   |   298233 | 28-06-2018   | ROMARK LABORATORIES L.C.                                                                                                                                                   |
|    642 | Hepatitis C Virus (HCV)   | 781/KOLNP/2010        | 02-03-2010   |   299529 | 31-07-2018   | PHARMAESSENTIA CORP.                                                                                                                                                       |
|    643 | Hepatitis C Virus (HCV)   | 718/KOL/2010          | 01-07-2010   |   300372 | 28-08-2018   | MAHAJAN; LALIT                                                                                                                                                             |
|    644 | Hepatitis C Virus (HCV)   | 117/MUMNP/2012        | 16-01-2012   |   305216 | 01-01-2019   | INDUSTRY ACADEMIC COOPERATION FOUNDATION, HALLYM UNIVERSITY                                                                                                                |
|    645 | Hepatitis C Virus (HCV)   | 2511/KOLNP/2014       | 07-11-2014   |   312614 | 10-05-2019   | JE IL PHARMACEUTICAL CO., LTD.                                                                                                                                             |
|    646 | Hepatitis C Virus (HCV)   | 443/DELNP/2014        | 20-01-2014   |   325970 | 27-11-2019   | GREEN CROSS CORPORATION.                                                                                                                                                   |
|    647 | Hepatitis C Virus (HCV)   | 894/CHENP/2014        | 04-02-2014   |   327764 | 19-12-2019   | SOUTHERN RESEARCH INSTITUTE                                                                                                                                                |
|    648 | Hepatitis C Virus (HCV)   | IN/PCT/2001/00128/MUM | 07-02-2001   |   212256 | 26-11-2007   | BOEHRINGER INGELHEIM (CANADA) LTD.                                                                                                                                         |
|    649 | Hepatitis C Virus (HCV)   | 387/KOLNP/2005        | 10-03-2005   |   213425 | 02-01-2008   | GENELABS TECHNOLOGIES INC.                                                                                                                                                 |
|    650 | Hepatitis C Virus (HCV)   | IN/PCT/2001/00467/DEL | 01-06-2001   |   214915 | 18-02-2008   | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,                                                                                                                              |
|    651 | Hepatitis C Virus (HCV)   | 2291/DELNP/2005       | 30-05-2005   |   219490 | 07-05-2008   | VIROPHARMA INCORPORATED.                                                                                                                                                   |
|    652 | Hepatitis C Virus (HCV)   | 1504/KOLNP/2004       | 08-10-2004   |   219924 | 14-05-2008   | VERTEX PHARMACEUTICAL INCORPORATED                                                                                                                                         |
|    653 | Hepatitis C Virus (HCV)   | 2197/DELNP/2004       | 28-07-2004   |   220357 | 26-05-2008   | BOEHRINGER INGELHEIM INTERNATIONAL GMBH                                                                                                                                    |
|    654 | Hepatitis C Virus (HCV)   | 938/CHENP/2005        | 16-05-2005   |   225039 | 30-10-2008   | F. HOFFMANN-LA ROCHE AG                                                                                                                                                    |
|    655 | Hepatitis C Virus (HCV)   | 2624/KOLNP/2005       | 19-12-2005   |   233649 | 01-04-2009   | BOEHRINGER INGELHEIM INTERNATIONAL GMBH                                                                                                                                    |
|    656 | Hepatitis C Virus (HCV)   | 1082/DELNP/2003       | 10-07-2003   |   234337 | 25-05-2009   | LG LIFE SCIENCES LTD.                                                                                                                                                      |
|    657 | Hepatitis C Virus (HCV)   | IN/PCT/2001/00580/DEL | 03-07-2001   |   235059 | 24-06-2009   | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE                                                                                                                               |
|    658 | Hepatitis C Virus (HCV)   | 359/KOLNP/2006        | 17-02-2006   |   236081 | 23-09-2009   | VERTEX PHARMACEUTICALS INCORPORATED                                                                                                                                        |
|    659 | Hepatitis C Virus (HCV)   | 391/DELNP/2003        | 13-03-2003   |   236723 | 17-11-2009   | CELLDEX THERAPEUTICS LIMITED                                                                                                                                               |
|    660 | Hepatitis C Virus (HCV)   | 1291/CHENP/2003       | 18-08-2003   |   237390 | 18-12-2009   | 1. ISIS PHARMACEUTICALS  INC                                                                                                                                          |

|   661. | Hepatitis C Virus (HCV)   | 270/KOLNP/2004        | 01-03-2004   |   239315 | 16-03-2010   | AVONTEC GMBH                                                      |
|--------|---------------------------|-----------------------|--------------|----------|--------------|-------------------------------------------------------------------|
|    662 | Hepatitis C Virus (HCV)   | 772/KOLNP/2006        | 30-03-2006   |   239543 | 24-03-2010   | VERTEX PHARMACEUTICALS INCORPORATED                               |
|    663 | Hepatitis C Virus (HCV)   | 1918/KOLNP/2005       | 26-09-2005   |   239748 | 31-03-2010   | AXYS PHARMACEUTICALS INC.                                         |
|    664 | Hepatitis C Virus (HCV)   | 597/KOLNP/2004        | 06-05-2004   |   241063 | 17-06-2010   | BEIJING WANTAI BIOLOGICAL PHARMACY ENTERPRISE CO. LTD.            |
|    665 | Hepatitis C Virus (HCV)   | 2245/DELNP/2006       | 24-04-2006   |   241460 | 06-07-2010   | INTERMUNE INC.                                                    |
|    666 | Hepatitis C Virus (HCV)   | 761/CHENP/2007        | 22-02-2007   |   241889 | 29-07-2010   | F. HOFFMANN-LA ROCHE AG                                           |
|    667 | Hepatitis C Virus (HCV)   | 760/CHENP/2008        | 14-02-2008   |   245185 | 06-01-2011   | F. HOFFMANN-LA ROCHE AG                                           |
|    668 | Hepatitis C Virus (HCV)   | 344/DELNP/2005        | 28-01-2005   |   245337 | 13-01-2011   | IDENIX (CAYMAN) LIMITED                                           |
|    669 | Hepatitis C Virus (HCV)   | IN/PCT/2002/01240/DEL | 13-12-2002   |   245685 | 28-01-2011   | IDENIX (CAYMAN) LIMITED                                           |
|    670 | Hepatitis C Virus (HCV)   | 1272/MUMNP/2008       | 20-06-2008   |   251171 | 28-02-2012   | F. HOFFMANN-LA ROCHE AG                                           |
|    671 | Hepatitis C Virus (HCV)   | 2704/DEL/2006         | 18-12-2006   |   251904 | 16-04-2012   | DEPARTMENT OF BIOTECHNOLOGY (DBT)                                 |
|    672 | Hepatitis C Virus (HCV)   | 3854/DELNP/2006       | 05-07-2006   |   252483 | 17-05-2012   | MEDIVIR AB                                                        |
|    673 | Hepatitis C Virus (HCV)   | 7158/DELNP/2007       | 17-09-2007   |   253900 | 31-08-2012   | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES |
|    674 | Hepatitis C Virus (HCV)   | 520/CHE/2005          | 02-05-2005   |   254638 | 29-11-2012   | INDIAN INSTITUTE OF SCIENCE                                       |
|    675 | Hepatitis C Virus (HCV)   | 5661/DELNP/2007       | 23-07-2007   |   255745 | 20-03-2013   | BRISTOL-MYERS SQUIBB COMPANY                                      |
|    676 | Hepatitis C Virus (HCV)   | 3860/DELNP/2006       | 05-07-2006   |   256631 | 10-07-2013   | MEDIVIR AB.                                                       |
|    677 | Hepatitis C Virus (HCV)   | 63/DEL/2004           | 16-01-2004   |   256702 | 18-07-2013   | SETH PRADEEP                                                      |
|    678 | Hepatitis C Virus (HCV)   | 6570/DELNP/2006       | 06-11-2006   |   257614 | 21-10-2013   | BIOGEN IDEC MAINC                                                 |
|    679 | Hepatitis C Virus (HCV)   | 4295/KOLNP/2007       | 07-11-2007   |   261785 | 15-07-2014   | VIROCHEM PHARMA INC                                               |
|    680 | Hepatitis C Virus (HCV)   | 4882/KOLNP/2007       | 14-12-2007   |   266545 | 14-05-2015   | VIROBAY, INC.                                                     |
|    681 | Hepatitis C Virus (HCV)   | 1416/CHENP/2008       | 24-03-2008   |   269603 | 29-10-2015   | ASTELLAS PHARMA INC                                               |
|    682 | Hepatitis C Virus (HCV)   | 391/MUMNP/2010        | 02-03-2010   |   270701 | 11-01-2016   | BIOSTEED GENE EXPRESSION TECH. CO.LTD.                            |
|    683 | Hepatitis C Virus         | 9964/DELNP/2008       | 01-12-2008   |   271605 | 27-02-2016   | MSD ITALIA S.R.L                                                  |

|     | (HCV)                   |                 |            |        |            |                                                        |
|-----|-------------------------|-----------------|------------|--------|------------|--------------------------------------------------------|
| 684 | Hepatitis C Virus (HCV) | 9336/DELNP/2008 | 07-11-2008 | 271822 | 07-03-2016 | BRISTOL - MYERS SQUIBB HOLDINGS IRELAND |
| 685 | Hepatitis C Virus (HCV) | 3648/CHENP/2010 | 15-06-2010 | 272551 | 07-04-2016 | MEDICAL RESEARCH COUNCIL TECHNOLOGY                    |
| 686 | Hepatitis C Virus (HCV) | 4129/CHENP/2008 | 06-08-2008 | 272906 | 02-05-2016 | BIO MERIEUX                                            |
| 687 | Hepatitis C Virus (HCV) | 7068/DELNP/2010 | 06-10-2010 | 275967 | 27-09-2016 | GILEAD SCIENCES, INC.                                  |
| 688 | Hepatitis C Virus (HCV) | 9721/DELNP/2007 | 14-12-2007 | 277792 | 30-11-2016 | BEIJING DIANFAN TECHNOLOGY LTD.                        |
| 689 | Hepatitis C Virus (HCV) | 5758/DELNP/2010 | 13-08-2010 | 279457 | 23-01-2017 | BRISTOL-MYERS SQUIBB COMPANY                           |
| 690 | Hepatitis C Virus (HCV) | 858/DELNP/2009  | 05-02-2009 | 284343 | 19-06-2017 | BRISTOL-MYERS SQUIBB COMPANY                           |
| 691 | Hepatitis C Virus (HCV) | 3615/KOLNP/2010 | 29-09-2010 | 284752 | 29-06-2017 | TAIGEN BIOTECHNOLOGY CO., LTD.                         |
| 692 | Hepatitis C Virus (HCV) | 3869/DELNP/2010 | 01-06-2010 | 285245 | 17-07-2017 | F. HOFFMANN-LA ROCHE LTD.                              |
| 693 | Hepatitis C Virus (HCV) | 5723/DELNP/2010 | 12-08-2010 | 286629 | 24-08-2017 | BRISTOL-MYERS SQUIBB COMPANY                           |
| 694 | Hepatitis C Virus (HCV) | 753/DELNP/2009  | 02-02-2009 | 288320 | 12-10-2017 | BRISTOL-MYERS SQUIBB COMPANY                           |
| 695 | Hepatitis C Virus (HCV) | 7404/DELNP/2010 | 20-10-2010 | 289041 | 31-10-2017 | GILEAD SCIENCES, INC.                                  |
| 696 | Hepatitis C Virus (HCV) | 263/DELNP/2009  | 13-01-2009 | 291705 | 15-01-2018 | MSD ITALIA S.R.L                                       |
| 697 | Hepatitis C Virus (HCV) | 2315/DELNP/2011 | 29-03-2011 | 292343 | 30-01-2018 | GEORGETOWN UNIVERSITY                                  |
| 698 | Hepatitis C Virus (HCV) | 6557/CHENP/2012 | 25-07-2012 | 293832 | 06-03-2018 | RIBOSCIENCE LLC                                        |
| 699 | Hepatitis C Virus (HCV) | 1369/MUMNP/2011 | 30-06-2011 | 296290 | 27-04-2018 | PRESIDIO PHARMACEUTICALS INC.                          |
| 700 | Hepatitis C Virus (HCV) | 6398/DELNP/2012 | 19-07-2012 | 296929 | 21-05-2018 | GREEN CROSS CORPORATION                                |
| 701 | Hepatitis C Virus (HCV) | 323/MUMNP/2010  | 18-02-2010 | 299275 | 26-07-2018 | ROMARK LABORATORIES L.C.                               |
| 702 | Hepatitis C Virus (HCV) | 6855/DELNP/2012 | 06-08-2012 | 301584 | 28-09-2018 | AB PHARMA LTD.                                         |
| 703 | Hepatitis C Virus (HCV) | 662/MUMNP/2012  | 15-03-2012 | 305870 | 18-01-2019 | TaiGen Biotechnology Co., Ltd.                         |
| 704 | Hepatitis C Virus (HCV) | 158/CHENP/2015  | 08-01-2015 | 314118 | 13-06-2019 | GREEN CROSS CORPORATION                                |

|   705. | Hepatitis C Virus (HCV)          | 984/KOLNP/2007        | 20-03-2007   |   314158 | 13-06-2019   | BEIJING WANTAI BIOLOGICAL PHARMACY ENTERPRISE CO. LTD.             |
|--------|----------------------------------|-----------------------|--------------|----------|--------------|--------------------------------------------------------------------|
|    706 | Hepatitis C Virus (HCV)          | 1826/DELNP/2006       | 03-04-2006   |   316095 | 16-07-2019   | MERCK SHARP & DOHME CORP.                                          |
|    707 | Hepatitis C Virus (HCV)          | 6114/DELNP/2012       | 10-07-2012   |   317300 | 31-07-2019   | GILEAD SCIENCES INC.                                               |
|    708 | Hepatitis C Virus (HCV)          | 1788/DEL/2012         | 11-06-2012   |   317516 | 02-08-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                        |
|    709 | Hepatitis C Virus (HCV)          | 9080/DELNP/2010       | 20-12-2010   |   318063 | 10-08-2019   | UNIVERSITE FRANCOIS RABELAIS DE TOURS                              |
|    710 | Hepatitis C Virus (HCV)          | 10964/DELNP/2013      | 19-12-2013   |   324724 | 08-11-2019   | INSERM (Institut National de la Santé et de la Recherche Médicale) |
|    711 | Hepatitis C Virus (HCV)          | 3446/CHENP/2012       | 17-04-2012   |   325514 | 21-11-2019   | GILEAD SCIENCES INC                                                |
|    712 | Hepatitis C Virus (HCV)          | 3925/DELNP/2015       | 08-05-2015   |   326444 | 29-11-2019   | CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA                      |
|    713 | Hepatitis C Virus (HCV)          | 2657/MUMNP/2014       | 30-12-2014   |   327414 | 16-12-2019   | GILEAD SCIENCES INC.                                               |
|    714 | Hepatitis C Virus (HCV), Cancer  | 5640/DELNP/2010       | 09-08-2010   |   277126 | 11-11-2016   | GENE TECHNO SCIENCE CO., LTD.                                      |
|    715 | Hepatitis C Virus (HCV), Cancer  | 5303/CHENP/2008       | 03-10-2008   |   280006 | 07-02-2017   | ASTELLAS PHARMA INC.                                               |
|    716 | Hepatitis C Virus (HCV), Cancer  | 7446/CHENP/2010       | 19-11-2010   |   302631 | 30-10-2018   | GENE TECHNO SCIENCE CO., LTD.                                      |
|    717 | Hepatitis C Virus (HCV), Diabets | 4113/CHENP/2006       | 08-11-2006   |   245141 | 04-01-2011   | ASTELLAS PHARMA INC                                                |
|    718 | HIV                              | IN/PCT/2002/01622/MUM | 15-11-2002   |   203969 | 03-11-2006   | BOEHRINGER INGELHEIM [CANADA] LTD.                                 |
|    719 | HIV                              | IN/PCT/2000/00145/DEL | 18-08-2000   |   199514 | 12-01-2007   | OY FINNISH IMMUNOECHNOLOGY LTD.                                    |
|    720 | HIV                              | 487/MAS/2001          | 18-06-2001   |   204225 | 12-02-2007   | DR. POTHURAJU SURYA VENKATA SATYANARAYANA                          |
|    721 | HIV                              | IN/PCT/2000/131/KOL   | 13-07-2000   |   201387 | 16-02-2007   | VERTEX PHARMACEUTICALS INCORPORATED                                |
|    722 | HIV                              | 486/MAS/2001          | 18-06-2001   |   204994 | 13-03-2007   | Dr. POTURAJU SURYA VENKATA SATYANARAYANA                           |
|    723 | HIV                              | 1074/DELNP/2003       | 08-07-2003   |   209104 | 20-08-2007   | CENTRO DE INGENIERIA GENETICA Y BIOTECHNOLOGIA                     |
|    724 | HIV                              | 492/CHENP/2003        | 07-04-2003   |   209213 | 22-08-2007   | M/S. F. HOFFMANN-LA ROCHE AG                                       |
|    725 | HIV                              | IN/PCT/2002/930/KOL   | 17-07-2002   |   209777 | 06-09-2007   | SMITHKLINE BEECHAM BIOLOGICALS S.A.                                |
|    726 | HIV                              | 3127/CHENP/2004       | 31-12-2004   |   209815 | 06-09-2007   | F. HOFFMANN-LA ROCHE AG                                            |
|    727 | HIV                              | 194/DEL/2004          | 12-02-2004   |   209857 | 07-09-2007   | YOGENDRA SINGH                                                     |
|    728 | HIV                              | 868/CHENP/2004        | 23-04-2004   |   212400 | 03-12-2007   | M/S. ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI, SPA |
|    729 | HIV                              | IN/PCT/2001/1520/CHE  | 02-11-2001   |   213133 | 20-12-2007   | SCHERING CORPORATION                                               |

|   730. | HIV   | IN/PCT/2000/430/KOL   | 23-10-2000   |   213437 | 02-01-2008   | INFECTIO RECHERCHE INC.                                                                                                                                                |
|--------|-------|-----------------------|--------------|----------|--------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    731 | HIV   | IN/PCT/2001/00123/DEL | 08-02-2001   |   213748 | 11-01-2008   | UNIVERSITY OF WESTERN ONTARIO                                                                                                                                          |
|    732 | HIV   | 00296/DELNP/2003      | 04-03-2003   |   215827 | 04-03-2008   | BIONOR IMMUNO AS,                                                                                                                                                      |
|    733 | HIV   | 528/KOLNP/2005        | 30-03-2005   |   216350 | 12-03-2008   | CHIRON CORPORATION                                                                                                                                                     |
|    734 | HIV   | 3779/DELNP/2004       | 30-11-2004   |   216703 | 18-03-2008   | JANSSEN SCIENCES IRELAND UC                                                                                                                                            |
|    735 | HIV   | 470/CHENP/2005        | 23-03-2005   |   218425 | 01-04-2008   | TRIMERIS, INC.                                                                                                                                                         |
|    736 | HIV   | 455/CHENP/2005        | 22-03-2005   |   218855 | 16-04-2008   | ARDEA BIOSCIENCES  INC                                                                                                                                            |
|    737 | HIV   | 00369/KOLNP/2004      | 19-03-2004   |   219313 | 30-04-2008   | GLAXO GROUP LIMITED                                                                                                                                                    |
|    738 | HIV   | IN/PCT/2001/01023/MUM | 30-08-2001   |   220237 | 21-05-2008   | BIONOR IMMUNO AS                                                                                                                                                       |
|    739 | HIV   | 82/KOLNP/2004         | 22-01-2004   |   222865 | 27-08-2008   | CHIRON CORPORATION                                                                                                                                                     |
|    740 | HIV   | 00265/DELNP/2004      | 06-02-2004   |   222987 | 29-08-2008   | JANSSEN PHARMACEUTICA N.V.                                                                                                                                             |
|    741 | HIV   | 1207/CHENP/2004       | 01-06-2004   |   223681 | 19-09-2008   | GENPHAR, INC                                                                                                                                                           |
|    742 | HIV   | 1675/MAS/1996         | 23-09-1996   |   224670 | 21-10-2008   | JAPAN TOBACCO INC.                                                                                                                                                     |
|    743 | HIV   | IN/PCT/2001/774/KOL   | 27-07-2001   |   225662 | 19-11-2008   | CHIRON CORPORATION                                                                                                                                                     |
|    744 | HIV   | 1361/KOLNP/2005       | 14-07-2005   |   225952 | 03-12-2008   | PROCYON BIOPHARMA INC                                                                                                                                                  |
|    745 | HIV   | 1073/CHENP/2004       | 14-05-2004   |   227967 | 27-01-2009   | THE GOVERNMENT OF THE USA REPRESENTED BY THE SECRETARY OF THE OF DEPARTMENT OF HEALTH AND HUMANSERVICES OF NATIONAL INSTITUTES OF HEALTH OFFICE OF TECHNOLOGY TRANSFER |
|    746 | HIV   | 1535/CHENP/2004       | 09-07-2004   |   229359 | 17-02-2009   | THE GOVERNMENT OF THE USA REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES                                                                  |
|    747 | HIV   | 3045/DELNP/2004       | 05-10-2004   |   233812 | 09-04-2009   | GILEAD SCIENCES, INC.                                                                                                                                                  |
|    748 | HIV   | 3412/DELNP/2005       | 01-08-2005   |   233845 | 16-04-2009   | NOVELIX PHARMACEUTICALS, INC.                                                                                                                                          |
|    749 | HIV   | 443/CAL/1999          | 12-05-1999   |   233888 | 16-04-2009   | GENECURE LLC                                                                                                                                                           |
|    750 | HIV   | 1509/DELNP/2003       | 19-09-2003   |   234835 | 17-06-2009   | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMANSERVICES                                                 |
|    751 | HIV   | IN/PCT/2002/00718/MUM | 03-06-2002   |   234913 | 19-06-2009   | MEDICAL RESEARCH COUNCIL                                                                                                                                               |
|    752 | HIV   | 1947/CHENP/2005       | 17-08-2005   |   235323 | 30-06-2009   | F. HOFFMANN-LA ROCHE AG                                                                                                                                                |
|    753 | HIV   | 3110/DELNP/2005       | 13-07-2005   |   235425 | 02-07-2009   | JANSSEN SCIENCES IRELAND UC                                                                                                                                            |
|    754 | HIV   | 2358/CHENP/2005       | 22-09-2005   |   237027 | 01-12-2009   | F. HOFFMANN-LA ROCHE AG                                                                                                                                                |
|    755 | HIV   | 975/DELNP/2006        | 24-02-2006   |   239717 | 30-03-2010   | TIBOTEC PHARMACEUTICALS LTD.                                                                                                                                           |
|    756 | HIV   | 1330/DEL/2004         | 19-07-2004   |   240422 | 10-05-2010   | PANDEY , SANTOSH KUMAR                                                                                                                                                 |
|    757 | HIV   | 2210/CAL/1998         | 23-12-1998   |   240930 | 10-06-2010   | VERTEX PHARMACEUTICALS INCORPORATED                                                                                                                                    |

|   758. | HIV   | 382/DELNP/2005   | 02-02-2005   |   242939 | 21-09-2010   | BRISTOL-MYERS SQUIBB COMPANY                                                                                                 |
|--------|-------|------------------|--------------|----------|--------------|------------------------------------------------------------------------------------------------------------------------------|
|    759 | HIV   | 1316/CHENP/2004  | 14-06-2004   |   245833 | 03-02-2011   | JAPAN TOBACCO INC                                                                                                            |
|    760 | HIV   | 1392/MUMNP/2007  | 11-09-2007   |   246999 | 24-03-2011   | BIONOR IMMUNO AS                                                                                                             |
|    761 | HIV   | 2118/MUMNP/2009  | 13-11-2009   |   248172 | 24-06-2011   | ELI LILLY AND COMPANY                                                                                                        |
|    762 | HIV   | 2623/DELNP/2004  | 08-09-2004   |   248360 | 07-07-2011   | EMORY UNIVERSITY                                                                                                             |
|    763 | HIV   | 2948/DELNP/2004  | 29-09-2004   |   248573 | 26-07-2011   | BAVARIAN NORDIC A/S                                                                                                          |
|    764 | HIV   | 2729/DEL/2005    | 10-10-2005   |   250151 | 12-12-2011   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                                                  |
|    765 | HIV   | 2183/MUMNP/2007  | 24-12-2007   |   250447 | 04-01-2012   | RAPID PHARMACEUTICALS AG                                                                                                     |
|    766 | HIV   | 1393/MUMNP/2007  | 11-09-2007   |   250449 | 04-01-2012   | BIONOR IMMUNO AS                                                                                                             |
|    767 | HIV   | 3593/KOLNP/2006  | 30-11-2006   |   252264 | 03-05-2012   | NOVARTIS VACCINES AND DIAGNOSTICS, INC.                                                                                      |
|    768 | HIV   | 3594/KOLNP/2006  | 30-11-2006   |   252338 | 09-05-2012   | NOVARTIS VACCINES AND DIAGNOSTICS, INC.                                                                                      |
|    769 | HIV   | 1391/MUMNP/2007  | 11-09-2007   |   253156 | 28-06-2012   | BIONOR IMMUNO AS                                                                                                             |
|    770 | HIV   | 621/KOLNP/2007   | 20-02-2007   |   253465 | 24-07-2012   | GLAXOSMITHKLINE BIOLOGICALS S.A.                                                                                             |
|    771 | HIV   | 2719/KOLNP/2007  | 23-07-2007   |   254080 | 18-09-2012   | UNIVERSITY OF WOLLONGONG                                                                                                     |
|    772 | HIV   | 336/CHENP/2007   | 25-01-2007   |   257217 | 13-09-2013   | F. HOFFMANN-LA ROCHE AG                                                                                                      |
|    773 | HIV   | 2361/CHENP/2005  | 22-09-2005   |   259497 | 14-03-2014   | F. HOFFMANN-LA ROCHE AG                                                                                                      |
|    774 | HIV   | 586/DELNP/2007   | 22-01-2007   |   259640 | 21-03-2014   | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMANSERVICES |
|    775 | HIV   | 1593/DELNP/2007  | 28-02-2007   |   260172 | 03-04-2014   | JANSSEN SCIENCES IRELAND UC                                                                                                  |
|    776 | HIV   | 1084/CHENP/2007  | 15-03-2007   |   261289 | 18-06-2014   | Shionogi& Co.,Ltd                                                                                                            |
|    777 | HIV   | 1232/CHENP/2007  | 23-03-2007   |   262812 | 16-09-2014   | ARDEA BIOSCIENCES, INC.,                                                                                                     |
|    778 | HIV   | 3889/CHENP/2006  | 23-10-2006   |   263380 | 24-10-2014   | F. HOFFMANN-LA ROCHE AG                                                                                                      |
|    779 | HIV   | 1315/DELNP/2008  | 14-02-2008   |   264593 | 07-01-2015   | TAKARA BIO INC.                                                                                                              |
|    780 | HIV   | 3402/KOLNP/2009  | 29-09-2009   |   271732 | 02-03-2016   | GLAXOSMITHKLINE BIOLOGICALS S.A.                                                                                             |
|    781 | HIV   | 7972/DELNP/2007  | 16-10-2007   |   272432 | 31-03-2016   | TIBOTEC PHARMACEUTICALS LTD.                                                                                                 |
|    782 | HIV   | 9071/DELNP/2010  | 20-12-2010   |   278257 | 19-12-2016   | BRISTOL-MYERS SQUIBB COMPANY                                                                                                 |
|    783 | HIV   | 4831/DELNP/2007  | 22-06-2007   |   278930 | 04-01-2017   | JANSSEN SCIENCES IRELAND UC                                                                                                  |
|    784 | HIV   | 3897/KOLNP/2008  | 25-09-2008   |   279268 | 17-01-2017   | MYMETICS CORPORATION                                                                                                         |
|    785 | HIV   | 3337/CHENP/2006  | 14-09-2006   |   281609 | 22-03-2017   | NEKTAR THERAPEUTICS                                                                                                          |
|    786 | HIV   | 4882/DELNP/2006  | 24-08-2006   |   284354 | 19-06-2017   | K.U. LEUVEN RESEARCH & DEVELOPMENT                                                                                           |
|    787 | HIV   | 3673/DELNP/2004  | 22-11-2004   |   288493 | 17-10-2017   | BRISTOL-MYERS SQUIBB COMPANY                                                                                                 |
|    788 | HIV   | 7388/DELNP/2008  | 29-08-2008   |   288574 | 23-10-2017   | JANSSEN R&D IRELAND                                                                                                          |
|    789 | HIV   | 7330/DELNP/2008  | 28-08-2008   |   289764 | 21-11-2017   | JANSSEN SCIENCES IRELAND UC                                                                                                  |

|   790. | HIV                            | 6367/DELNP/2006   | 30-10-2006   |   289772 | 21-11-2017   | Schering Corporation                                                           |
|--------|--------------------------------|-------------------|--------------|----------|--------------|--------------------------------------------------------------------------------|
|    791 | HIV                            | 584/MUM/2007      | 29-05-2007   |   291708 | 15-01-2018   | SAURASHTRA UNIVERSITY                                                          |
|    792 | HIV                            | 196/KOLNP/2011    | 13-01-2011   |   291942 | 22-01-2018   | VIIV HEALTHCARE COMPANY                                                        |
|    793 | HIV                            | 3328/DELNP/2011   | 04-05-2011   |   295729 | 12-04-2018   | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. |
|    794 | HIV                            | 01124/DELNP/2003  | 17-07-2003   |   297089 | 25-05-2018   | VIIV HEALTHCARE UK (NO. 4) LIMITED                                             |
|    795 | HIV                            | 257/MUM/2011      | 31-01-2011   |   299505 | 31-07-2018   | CADILA HEALTHCARE LIMITED                                                      |
|    796 | HIV                            | 2302/CHENP/2009   | 24-04-2009   |   299641 | 02-08-2018   | MEDAREX LLC                                                                    |
|    797 | HIV                            | 1196/DELNP/2010   | 22-02-2010   |   301284 | 24-09-2018   | INSTITUT PASTEUR                                                               |
|    798 | HIV                            | 1556/DEL/2009     | 28-07-2009   |   304819 | 21-12-2018   | NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH                    |
|    799 | HIV                            | 7836/CHENP/2014   | 24-10-2014   |   305662 | 14-01-2019   | VIIV HEALTHCARE UK (NO.5) LIMITED                                              |
|    800 | HIV                            | 1685/DEL/2009     | 12-02-2010   |   310696 | 01-04-2019   | INDIAN COUNCIL OF MEDICAL RESEARCH                                             |
|    801 | HIV                            | 8211/CHENP/2012   | 24-09-2012   |   311693 | 26-04-2019   | MERCK CANADA INC.                                                              |
|    802 | HIV                            | 1451/CHENP/2013   | 22-02-2013   |   326576 | 02-12-2019   | LIFE TECHNOLOGIES CORPORATION                                                  |
|    803 | HIV                            | 2132/MUMNP/2011   | 11-10-2011   |   327493 | 16-12-2019   | JANSSEN SCIENCES IRELAND UC                                                    |
|    804 | HIV                            | 2411/CHE/2014     | 15-05-2014   |   327537 | 17-12-2019   | Dr. MANOHAR.P.SHINHASAN                                                        |
|    805 | HIV,Cancer                     | 1136/MUMNP/2003   | 15-12-2003   |   241094 | 17-06-2010   | THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY                                    |
|    806 | HIV,Cancer                     | 1011/MUM/2008     | 13-05-2008   |   256633 | 10-07-2013   | SHELAR ASHOK RANGANATH                                                         |
|    807 | HIV,Cancer                     | 2101/KOLNP/2005   | 24-10-2005   |   261319 | 19-06-2014   | POLYPHOR AG                                                                    |
|    808 | HIV,Cancer                     | 9440/CHENP/2013   | 25-11-2013   |   327647 | 18-12-2019   | POLYPHOR AG                                                                    |
|    809 | HIV,Cardiovascular diseases    | 2106/CHENP/2006   | 15-06-2006   |   235117 | 25-06-2009   | SCHERING CORPORATION                                                           |
|    810 | HIV,Cardiovascular diseases    | 2535/CHENP/2007   | 13-06-2007   |   240012 | 22-04-2010   | SCHERING CORPORATION                                                           |
|    811 | HIV,Cardiovascular diseases    | 4921/CHENP/2009   | 21-08-2009   |   271295 | 15-02-2016   | MERCK SHARP & DHOME CORP                                                   |
|    812 | HIV,HCV                        | 298/DEL/2001      | 16-03-2001   |   219874 | 13-05-2008   | SAGE R & D                                                                     |
|    813 | HIV,HCV                        | 1928/DEL/1997     | 10-07-1997   |   243564 | 26-10-2010   | SAGE R&D                                                                       |
|    814 | HIV,HCV                        | 2626/MUMNP/2008   | 10-12-2008   |   251679 | 28-03-2012   | SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES               |
|    815 | HIV,HCV                        | 1814/DELNP/2007   | 08-03-2007   |   260243 | 15-04-2014   | EMORY UNIERSITY                                                                |
|    816 | HIV,HCV,Cancer, Cardiovascular | 1054/CHENP/2007   | 13-03-2007   |   259511 | 14-03-2014   | ONO PHARMACEUTICAL CO., LTD.                                                   |
|    817 | HIV,Tuberculosis               | 1136/MUMNP/2010   | 29-05-2010   |   268729 | 15-09-2015   | INSTITUTE OF MATARIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES                |

|   818. | Tuberculosis   | IN/PCT/2001/523/KOL   | 16-05-2001   |   210110 | 18-09-2007   | KONSTANTINOVA ROUMIANA GUEORGUIEVA                                                        |
|--------|----------------|-----------------------|--------------|----------|--------------|-------------------------------------------------------------------------------------------|
|    819 | Tuberculosis   | 199/KOLNP/2004        | 13-02-2004   |   225634 | 19-11-2008   | NEW YORK UNIVERSITY                                                                       |
|    820 | Tuberculosis   | 816/KOLNP/2004        | 14-06-2004   |   227294 | 06-01-2009   | NEED PHARMACEUTICALS S. R. L.                                                             |
|    821 | Tuberculosis   | 1062/DEL/2003         | 28-08-2003   |   227532 | 13-01-2009   | Council of Scientific and Industrial Research                                             |
|    822 | Tuberculosis   | 969/MAS/1998          | 05-05-1998   |   228460 | 05-02-2009   | ASTRA AB                                                                                  |
|    823 | Tuberculosis   | 293/MAS/1995          | 13-03-1995   |   229252 | 16-02-2009   | ASTRA RESEARCH CENTRE INDIA                                                               |
|    824 | Tuberculosis   | 457/CHE/2004          | 14-05-2004   |   234756 | 15-06-2009   | INDIAN INSTITUTE OF SCIENCE,                                                              |
|    825 | Tuberculosis   | 527/MUM/2004          | 07-05-2004   |   235145 | 26-06-2009   | SAPTE VINAY RAMAKANT                                                                      |
|    826 | Tuberculosis   | 2167/CHENP/2006       | 16-06-2006   |   236862 | 25-11-2009   | DONG-A PHARM.CO. LTD.                                                                     |
|    827 | Tuberculosis   | 584/MUM/2004          | 21-05-2004   |   239160 | 09-03-2010   | ADVANCE ENZYME TECHNOLOGIES LIMITED                                                       |
|    828 | Tuberculosis   | 1522/MUMNP/2006       | 13-12-2006   |   239270 | 15-03-2010   | LUPIN LIMITED                                                                             |
|    829 | Tuberculosis   | 1063/MUM/2006         | 06-07-2006   |   240582 | 19-05-2010   | DR. RAJESH SHAH                                                                           |
|    830 | Tuberculosis   | 1760/DEL/2004         | 17-09-2004   |   244289 | 29-11-2010   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                               |
|    831 | Tuberculosis   | 1599/DEL/2003         | 23-12-2003   |   248630 | 28-07-2011   | ALL INDIA INSTITUTE OF MEDICAL SCIENCE                                                    |
|    832 | Tuberculosis   | 600/KOLNP/2005        | 08-04-2005   |   250365 | 29-12-2011   | OTSUKA PHARMACEUTICAL CO., LTD.                                                           |
|    833 | Tuberculosis   | 534/MUM/2008          | 18-03-2008   |   252551 | 22-05-2012   | SHELAR ASHOK RANGANATH                                                                    |
|    834 | Tuberculosis   | 3391/CHENP/2006       | 18-09-2006   |   255197 | 01-02-2013   | INSTITUTO FINLAY. CENTRO DE INVESTIGACION-PRODUCCION DE                                   |
|    835 | Tuberculosis   | 2107/CHENP/2007       | 16-05-2007   |   258128 | 06-12-2013   | CRUCELL HOLLAND B.V.                                                                      |
|    836 | Tuberculosis   | 882/DEL/2003          | 09-07-2003   |   259594 | 19-03-2014   | INDIAN COUNCIL OF MEDICAL RESEARCH                                                        |
|    837 | Tuberculosis   | 2272/DELNP/2007       | 23-03-2007   |   263207 | 14-10-2014   | JANSSEN PHARMACEUTICA N.V.,                                                               |
|    838 | Tuberculosis   | 668/DELNP/2008        | 24-01-2008   |   265953 | 25-03-2015   | JANSSEN PHARMACEUTICA N.V                                                                 |
|    839 | Tuberculosis   | 8123/DELNP/2008       | 26-09-2008   |   268173 | 19-08-2015   | UNIVERSIDAD DE ZARAGOZA                                                                   |
|    840 | Tuberculosis   | 1024/DEL/2006         | 20-04-2006   |   268314 | 25-08-2015   | NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH                               |
|    841 | Tuberculosis   | 2623/DEL/2008         | 20-11-2008   |   269311 | 15-10-2015   | PANACEA BIOTEC LIMITED                                                                    |
|    842 | Tuberculosis   | 3305/CHE/2008         | 29-12-2008   |   275061 | 22-08-2016   | SABITHA PALEMPALLI                                                                        |
|    843 | Tuberculosis   | 261/KOLNP/2010        | 21-01-2010   |   278976 | 05-01-2017   | LEIBNIZ-INSTITUT FOR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E.V. HANS-KNOLL-INSTITUT |
|    844 | Tuberculosis   | 1025/DEL/2006         | 20-04-2006   |   279395 | 19-01-2017   | NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH                               |
|    845 | Tuberculosis   | 6565/DELNP/2009       | 14-10-2009   |   283276 | 11-05-2017   | INFECTIOUS DISEASE-RESEARCH INSTITUTE                                                     |

********

|   846. | Tuberculosis         | 5080/KOLNP/2008   | 15-12-2008   |   283854 | 31-05-2017   | LEIBNIZ INSTITUTE FOR NATURAL PRODUCT RESEARH AND INFECTION BIOLOGY E. V.-HANS-KNOELL-INSTITUT (HKI)   |
|--------|----------------------|-------------------|--------------|----------|--------------|--------------------------------------------------------------------------------------------------------|
|    847 | Tuberculosis         | 4383/CHENP/2009   | 23-07-2009   |   284750 | 29-06-2017   | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)                                                |
|    848 | Tuberculosis         | 628/DEL/2002      | 11-06-2002   |   285387 | 19-07-2017   | NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH (NIPER)                                    |
|    849 | Tuberculosis         | 1069/DEL/2010     | 06-05-2010   |   285763 | 28-07-2017   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                            |
|    850 | Tuberculosis         | 6354/DELNP/2010   | 08-09-2010   |   286005 | 02-08-2017   | TENNOR THERAPEUTICS LIMITED                                                                            |
|    851 | Tuberculosis         | 1751/DEL/2008     | 25-07-2008   |   291005 | 22-12-2017   | DEPARTMENT OF BIOTECHNOLOGY (DBT),                                                                     |
|    852 | Tuberculosis         | 182/DEL/2010      | 29-01-2010   |   294354 | 15-03-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                            |
|    853 | Tuberculosis         | 1580/DEL/2011     | 03-06-2011   |   294724 | 21-03-2018   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                            |
|    854 | Tuberculosis         | 3579/DELNP/2012   | 24-04-2012   |   296234 | 27-04-2018   | ABELA PHARMACEUTICALS, INC.                                                                            |
|    855 | Tuberculosis         | 4585/KOLNP/2007   | 27-11-2007   |   296468 | 02-05-2018   | GLAXOSMITHKLINE BIOLOGICALS S.A.                                                                       |
|    856 | Tuberculosis         | 811/DELNP/2009    | 03-02-2009   |   298096 | 26-06-2018   | INSTITUT PASTEUR DE LILLE                                                                              |
|    857 | Tuberculosis         | 119/KOLNP/2011    | 10-01-2011   |   302948 | 07-11-2018   | GLAXOSMITHKLINE BIOLOGICALS S.A.                                                                       |
|    858 | Tuberculosis         | 2759/KOLNP/2012   | 21-09-2012   |   303197 | 16-11-2018   | STELLENBOSCH UNIVERSITY                                                                                |
|    859 | Tuberculosis         | 329/MUMNP/2013    | 19-02-2013   |   303747 | 29-11-2018   | FOUNDATION FOR NEGLECTED DISEASE RESEARCH                                                              |
|    860 | Tuberculosis         | 3594/CHE/2012     | 30-08-2012   |   304256 | 10-12-2018   | MAILAVARAM RAGHU PRASAD                                                                                |
|    861 | Tuberculosis         | 4543/DELNP/2010   | 23-06-2010   |   305681 | 15-01-2019   | AERAS GLOBAL TB VACCINE FOUNDATION                                                                     |
|    862 | Tuberculosis         | 2222/MUMNP/2012   | 20-09-2012   |   309007 | 11-03-2019   | JOINT STOCK COMPANY "PHARMASYNTEZ"                                                                     |
|    863 | Tuberculosis         | 4774/DELNP/2013   | 29-05-2013   |   311965 | 30-04-2019   | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)                                                        |
|    864 | Tuberculosis         | 1903/MUM/2013     | 30-05-2013   |   318652 | 21-08-2019   | INSTITUTE OF PHARMACY, NIRMA UNIVERSITY                                                                |
|    865 | Tuberculosis         | 201621002153      | 20-01-2016   |   321600 | 26-09-2019   | Dr. Hitesh D. Patel                                                                                    |
|    866 | Tuberculosis         | 1444/MUMNP/2013   | 25-07-2013   |   322497 | 10-10-2019   | ARCHIVEL FARMA SL                                                                                      |
|    867 | Tuberculosis         | 1311/DEL/2010     | 04-06-2010   |   323383 | 22-10-2019   | NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH (NIPER)                                    |
|    868 | Tuberculosis         | 4452/CHENP/2013   | 11-06-2013   |   327665 | 18-12-2019   | Scientific Center of Antiinfectious Drugs, Joint-Stock Company                                         |
|    869 | Tuberculosis, Cancer | 2172/DEL/2010     | 14-09-2010   |   318504 | 20-08-2019   | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH                                                            |