Lok Sabha Question No. 1933 (UNSTARRED), answered on 2017-03-14
Subject: Fixed Drugs Combinations
Ministry: CHEMICALS AND FERTILIZERS
Asked by: B. SREERAMULU

## GOVERNMENT OF INDIA MINISTRY OF CHEMICALS AND FERTILIZERS DEPARTMENT OF PHARMACEUTICALS

## LOK SABHA

## UNSTARRED QUESTION No. 1933

## TO BE ANSWERED ON THE 14 th  March, 2017

## Fixed Dose Combinations

1933. SHRI B. SRIRAMULU:

Will the Minister of CHEMICALS AND FERTILIZERS be pleased to state:

- (a) whether the Government has constituted an expert committee under the chairmanship of Prof. C.K. Kokate to frame guidelines for the approval and use of Fixed Drugs Combinations (FDC) across the country;
- (b) if so, the details thereof;
- (c) whether the Government has banned FDC medicines on the basis of Prof. C.K. Kokate Committee Report and if so, the list of FDC medicines banned in the country; and
- (d)  the  steps  taken/being  taken  by  the  Government  so  far  to  ensure marketing of only the approved FDC medicines to the public?

## ANSWER

## MINISTER OF STATE IN THE MINISTRY OF ROAD TRANSPORT AND HIGHWAYS; MINISTRY OF SHIPPING AND MINISTRY OF CHEMICALS AND FERTILIZERS (SHRI MANSUKH L. MANDAVIYA)

- (a) & (b): An expert committee was constituted by Ministry of Health and Family Welfare under the Chairmanship of Prof. C. K. Kokate, Vice chancellor,  KLE  University,  Belgaum  vide  order  no.  12-01/12-DC    (Pt. 133)/DFQC dated 06.02.2013 to formulate  policy guidelines and procedures for approval of Fixed dose Combinations.
- (c): Ministry of Health and Family Welfare vide order no. X.11035/53/2014DFQC  dated  16.09.2014 constituted an Expert Committee  under the chairmanship  of  Prof.  C.  K.  Kokate  for  examination  of  FDCs  licensed  to manufacture  for  sale  in  the  country  without  due  approval  from  office  of DCG(I). On the basis of the recommendations of the said Expert Committee and  in  exercise  of  powers  conferred  by  section  26A  of  the  Drugs  and Cosmetics Act, 1940 (23 of 1940), the Central Government prohibited the manufacture for sale, sale and distribution for

human use of 344 drug fixed dose combination vide gazette notification no. S.O  705(E)  to  1048(E)  dated  10.03.2016.  (List  of  344  FDC  medicines banned  in  the  country  is  enclosed  as  Annexure  A).  However,  various stakeholders filed various writ petitions in different High  Courts across the country and the said notification was quashed by Hon'ble High Court of Delhi vide  its  order  dated  01.12.2016.  Further,  the  Union  of  India  had  already challenged the order of Delhi High Court before the Supreme Court by way of SLP. The same is yet to be listed.

(d): Directions under Section 33 (P) of Drugs & Cosmetics Act, 1940 were issued initially by the Central Government to Principal/ Health Secretaries of all  state/  UTs  on  20.07.2000  for  not  granting  licences  for  manufacture  for sale of drugs considered as New Drugs without prior approval of DCG(I). The last  such  statutory  direction  was  issued  by  the  Ministry  vide  letter  No. X11011/1/2011-DFQC dated 1st October, 2012.  The Drugs and Cosmetics Rules were also amended in 2002 to bring clarity that the applicant, while applying to State Licensing Authority for grant of manufacturing license for New drug shall submit approval from DCG(I) to manufacture the New drug.

xxxxxx

Statement referred to in reply to part (c) of Lok Sabha Unstarred Q. No. 1933 for 14.03.2017 raised by Shri B. Sriramulu regarding 'Fixed Dose Combination'

LIST  OF  344  FDCs  PROHIBITED  FOR  MANUFACTURE  AND  SALE THROUGH VIDE GAZETTE NOTIFICATION NO. S.O 705(E) TO 1048(E) DATED 10.03.2016. UNDER DRUGS AND COSMETICS ACT, 1940 BY THE MINISTRY OF HEALTH AND FAMILY WELFARE

1. Aceclofenac + Paracetamol + Rabeprazole
2. Nimesulide  + Diclofenac
3. Nimesulide  + Cetirizine  +Caffeine
4. Nimesulide +Tizanidine
5. Paracetamol + cetrizine + caffeine
6. Diclofenac   + Tramadol   + Chlorzoxazone
7. Dicyclomine  +Paracetamol +Domperidone
8. Nimesulide +Paracetamol  dispesible tablets
9. Paracetamol + Phenylephrine  + Caffeine
10. Diclofenac +Tramadol +Paracetamol
11. Diclofenac + paracetamol + chlorzoxazone + famotidine
12. Naproxen+Paracetamol
13. Nimesulide + serratiopeptidase
14. Paracetamol +Diclofenac  +Famotidine
15. Nimesulide + Pitofenone + Fenpiverinium  + benzyl alcohol
16. Omeprazole + Paracetamol + Diclofenac
17. Nimesulide  + Paracetamol injection
18. Tamsulosin  + diclofenac
19. Paracetamol +Phenylephirine +Chlorpheniramine +Dextromethorphan  +Caffeine
20. Diclofenac  +Zinc Carnosine
21. Diclofenac  + paracetamol+ chlorpheniramine maleate + magnesium trisillicate
22. Paracetamol + pseudoephdrine + cetrizine
23. Phenylbutazone+Sodium Salicylate
24. Lornoxicam+Paracetamol+Trypsin
25. Paracetamol +Mefenamic Acid +Ranitidine +Dicyclomine
26. Nimesulide  + Dicyclomine
27. Heparin  +Diclofenac
28. Glucosamine  +Methyl Sulfonyl Methane+Vitamin D3 + Manganese + Boron+ Copper +Zinc
29. Paracetamol +Tapentadol
30. Tranexamic Acid  + Proanthocyanidin
31. Benzoxonium Chloride+Lidocaine
32. Lornoxicam +Paracetamol +Tramadol
116.  Metformin Hydrochlopride +Gliclazide +Piogllitazone +Chromium Polynicotinate
117.  Metformin  +Gliclazide +Chromium Polynicotinate
118.  Glibenclamide + Metformin  (SR)+ Pioglitazone
119.  Metformin (sustainded release) 500mg+Pioglitazone 15 mg+Glimepride 3mg
120.  Metformin (SR) 500mg+Pioglitazone 5mg
121.  Chloramphenicol +Beclomethasone  +Clomitrimazole +Lignocaine
122.  Clotrimazole  +  Ofloxaxin  +  Lignocaine  +  glycerine  and  propylene glycol
123.  Chloramphennicol+Lignocain+Betamethasone+Clotrimazole+

| 33.     | Lornoxicam +Paracetamol +Serratiopeptidase                                                                                |
|---------|---------------------------------------------------------------------------------------------------------------------------|
| 34.     | Diclofenac +Paracetamol +Magnesium trisilicate                                                                            |
| 35.     | Paracetamol +Domperidone +Caffeine                                                                                        |
| 36.     | Ammonium Chloride +Sodium Citrate +Chlorpheniramine Maleate +Menthol                                                      |
| 37.     | Paracetamol +Prochlorperazine Maleate                                                                                     |
| 38.     | Combikit of 3 tablets of Serratiopeptidase (enteric coated 20000 units) + Diclofenac Potassium & 2 tablets of Doxycycline |
| 39.     | Nimesulide +Paracetamol suspension                                                                                        |
| 40.     | Aceclofenac +Paracetamol +Famotidine                                                                                      |
| 41.     | Aceclofenac + Zinc Carnosine                                                                                              |
| 42.     | Paracetamol + disodium Hydrogen Citrate + Caffeine                                                                        |
| 43.     | Paracetamol + DL Methionine                                                                                               |
| 44.     | Disodium Hydrogen citrate +Paracetamol                                                                                    |
| 45.     | Paracetamol + Caffeine + Codeine Phosphate                                                                                |
| 46.     | Aceclofenac (SR) + Paracetamol                                                                                            |
| 47.     | Diclofenac + Paracetamol injection                                                                                        |
| 48.     | Azithromycin+Cefixime                                                                                                     |
| 49.     | Amoxicillin +Dicloxacillin                                                                                                |
| 50.     | Amoxicillin 250 mg+Potassium Clavulanate Diluted 62.5 mg                                                                  |
| 51.     | Azithromycin + Levofloxacin                                                                                               |
| 52.     | Cefixime +Linezolid                                                                                                       |
| 53.     | Amoxicillin +Cefixime +Potassium Clavulanic Acid                                                                          |
| 54.     | Ofloxacin +Nitazoxanide                                                                                                   |
| 55.     | Cefpodoxime Proxetil +Levofloxacin                                                                                        |
| 56.     | Combikit of Azithromycin dihydrate, secnidazole and fluconazole                                                           |
| 57.     | Levofloxacin +Ornidazole +Alpha Tocopherol Acetate                                                                        |
| 58.     | Nimorazole+Ofloxacin                                                                                                      |
| 59.     | Azithromycin + ofloxacin                                                                                                  |
| 60.     | amoxycillin + tinidazole                                                                                                  |
| 61.     | Doxycycline +Serratiopeptidase                                                                                            |
| 62.     | Cefixime +levofloxacin                                                                                                    |
| 63.     | Ofloxacin +Metronidazole +Zinc Acetate                                                                                    |
| 64.     | Diphenoxylate +Atropine +Furazolidone                                                                                     |
| 65.     | Combikit of Fluconazole Tablet, Azithromycin Tablet and Ornidazole                                                        |
| 66.     | Tablets Ciprofloxacin +Phenazopyridine                                                                                    |
| 67.     | +Dicloxacillin                                                                                                            |
|         | Amoxycillin +Serratiopeptidase                                                                                            |
| 68. 69. | Azithromycin +Cefpodoxime Lignocaine+Clotrimazole+Ofloxacin+Beclomethasone                                                |
| 70.     | Cafuroxime + Linezolid                                                                                                    |
| 71.     | Ofloxacin +Ornidazole +Zinc bisglycinate                                                                                  |
| 72.     | Metronidazole +Norfloxacin                                                                                                |
| 73.     | Amoxicillin+Bromhexine                                                                                                    |
| 74.     | +Fluticasone +Clotrimazole                                                                                                |
|         | Ciprofloxacin +Neomycin                                                                                                   |

| 75.       | Metronidazole +Tetracycline                                                                                             |
|-----------|-------------------------------------------------------------------------------------------------------------------------|
| 76.       | Cephalexin + Neomycin +Prednisolone                                                                                     |
| 77.       | Azithromycin + Ambroxol                                                                                                 |
| 78.       | cilnidipine + metroprolol succinate + metroprolol tartrate                                                              |
| 79.       | L-Arginine +Sildenafil                                                                                                  |
| 80.       | atorvastatin + vitamin D3 + folic acid + vitamin B12 + pyridoxine                                                       |
| 81.       | Metformin+Atorvastatin                                                                                                  |
| 82.       | Clindamycin+Telmisartan                                                                                                 |
| 83.       | Olmesartan+Hydrochlorothiazide +Chlorthalidone                                                                          |
| 84.       | L-5-Methylterahydrofolate calcium + Escitalopram                                                                        |
| 85.       | pholcodine +Promethazine                                                                                                |
| 86.       | Paracetamol +Promethazine                                                                                               |
| 87.       | Betahistine +Ginkgo Biloba Extract+Vinpocetine+Piracetam                                                                |
| 88.       | Cetirizine Dihydrochloride +Diethyl Carbamazine                                                                         |
| 89.       | Doxylamine +Pyridoxine +Mefenamic Acid+Paracetamol                                                                      |
| 90.       | Drotaverine + Clidinium + Chlordiazepoxide                                                                              |
| 91.       | Imipramine + Diazepam                                                                                                   |
| 92.       | Flupentixol +Escitalopram                                                                                               |
| 93.       | Paracetamol + Prochloperazine                                                                                           |
| 94.       | Gabapentin +Mecobalamin +Pyridoxine +Thiamine                                                                           |
| 95.       | Imipramine +Chlordiazepoxide +Trifluoperazine +Trihexyphenidyl                                                          |
| 96. 97.   | Chlorpromazine +Trihexyphenidyl                                                                                         |
| 98.       | Ursodeoxycholic Acid + Silymarine Metformin 1000/1000/500/500mg +Pioglitazone 7.5/7.5/7.5/7.5mg + Glimepiride 1/2/1/2mg |
| 99.       | 80 mg + metformin                                                                                                       |
|           | Gliclazide 325 mg                                                                                                       |
| 100.      | Voglibose+ Metformin + Chromium Picolinate                                                                              |
| 101. 102. | Pioglitazone 7.5/7.5mg+Metformin 500/1000mg Glimepiride 1mg/2mg/3mg+Pioglitazone                                        |
| 103.      | 15mg/15mg/15mg+Metformin 1000mg/1000mg/1000mg glimepiride 1mg/2mg+ pioglitazone 15mg/15mg + metformin                   |
| 104.      | 850mg/850mg Metformin 850mg+Pioglitazone 7.5 mg+Glimepiride 2mg                                                         |
| 105.      | Metformin 850mg+Pioglitazone 7.5 mg+Glimepiride 1mg                                                                     |
| 106.      | Metformin 500mg/500mg+Gliclazide SR 30mg/60mg+Pioglitazone 7.5mg/7.5mg                                                  |
| 107.      | Voglibose+Pioglitazone+Metformin                                                                                        |
| 108.      | Metformin +bromocriptine                                                                                                |
| 109.      | Metformin +Glimepiride +Methylcobalamin                                                                                 |
| 110.      | Pioglitazone 30 mg+Metformin 500mg                                                                                      |
| 111.      | Glimepiride +Pioglitazone +Metformin                                                                                    |
| 112.      | Glipizide 2.5mg+Metformin 400mg                                                                                         |
| 113.      | Pioglitazone 15mg+Metformin 850 mg                                                                                      |
| 114.      | Metformin ER+Gliclazide MR+Voglibose                                                                                    |
| 115.      | Chromium Polynicotinate+Metformin Hydrochloride                                                                         |

## Ofloxacin+Antipyrine

124.  Ofloxacin +Clotrimazole +Betamethasone  +Lignocaine
125.  Gentamicin Sulphate +Clotrimazole +Betamethasone  +Lignocaine
126.  Clotrimazole +Beclomethasone  +Ofloxacin +Lignocaine
127.  Becloemthasone +Clotrimazole+Chloramphenicol+Gentamycin +Lignocaine  Ear drops
128.  Flunarizine  + Paracetamole+ Domperidone
129.  Rabeprazole  +Zinc carnosine
130.  magaldrate + famotidine + simethicone
131.  cyproheptadine + thiamine
132.  Magaldrate +Ranitidine +Pancreatin +Domperidone
133.  Ranitidine  +Magaldrate +simethicone
134.  magaldrate + papain+ fungul diastase + simethicone
135.  Rabeprazole + zinc  + domperidone
136.  Famotidine + oxytacaine + Magaldrate
137.  Ranitidine+Domperidone+Semithicone
138.  Alginic Acid+Sodium Bicarbonate+Dried Aluminium Hydroxide+Magnesium Hydroxide
139.  Clidinium  +Paracetamol +Dicyclomine  +Activated Dimethicone
140.  Furazolidone +Metronidazole +Loperamide
141.  Rabeprazole  +Diclofenac  +Paracetamol
142.  Ranitidine  +Magaldrate
143.  Norfloxacin+ Metronidazole  + zinc Acetate
144.  Zinc Carnosine+Oxetacaine
145.  Oxetacaine +Magaldrate +Famotidine
146.  Pantoprazole  (as  Enteric  Coated  Tablet)+Zinc  Carnosine  (as  Film Coated Tablets)
147.  Zinc  Carnosine+MagnesiumHydroxide  +Dried  Aluminium  Hydroxide +Simethicone
148.  Zinc Carnosine+Sucralfate
149.  Mebeverine  Hydrochloride    &  Inner  HPMC  capsule  (Streptococcus Faecalis  +Clostridium  butyricum  +Bacillus  mesentricus+Lactic  Acid Bacillus)
150.  Clindamycin +Clotrimazole +Lactic Acid Bacillus
151.  Sildenafil +Estradiol Valerate
152.  Clomifene Citrate +Ubidecarenone +Zinc +Folic Acid +Methylcobalamin +Pyridoxine  +Lycopene +Selenium+Levocarnitine Tartrate+L-Arginine
153.  Thyroxine + Pyridoxine + Folic Acid
154.  Gentamycin+Dexamethasone+Chloramphenicol+Tobramycin+ Ofloxacin
155.  Dextromethorphan + Levocetirizine  +Phenylephrine  +Zinc
156.  Nimesulide +Loratadine +Phenylephrine  +Ambroxol
157.  Bromhexine  +Phenylephrine  +Chlorepheniramine Maleate
158.  Dextromethorphan + bromhexine +Guaiphenesin
159.  Paracetamol + Loratadine + phenylephrine  + Dextromethorphan  + caffeine
160.  Nimesulide + Phenylephrine  + Ceffeine+ levocetirizine
161.  Azithromycin  + acebrophyline
162.  Diphenhydramine  +Terpine  +Ammonium Chloride +Sodium Chloride +Menthol
163.  Nimesulide+Paracetamol+Cetrizine +Phenylephrine
164.  paracetamol+ loratadine + dextromethophan + pseudoepheridine  + caffeine
165.  chlorpheniramine  maleate+  dextromethophan+  dextromethophan    + guaiphenesin + ammonium chloride + menthol
166.  Chlorpheniramine Maleate+Ammonium Chloride+Sodium Citrate
167.  Cetirizine  +Phenylephrine  +Paracetamol +Zinc Gluconate
168.  Ambroxol    +Guaiphenesin  +Ammonium  Chloride  +Phenylephrine +Chlorpheniramine Maleate +Menthol
169.  dextromethophen    +  bromhexine    +  chlorpheniramine  maleate  + guaiphenesin
170.  levocetirizine + ambroxol  + phenylephrine   +guaiphenesin
171.  dextromethorphan + chlorpheniramine + chlorpheniramine maleate
172.  cetirizine + ambroxol + Guaiphenesin + ammonium  chloride+ phenylephrine+ menthol
173.  chlorpheniramine  + phenylephrine + caffiene
174.  dextromethorphan + triprolidine + phenylephrine
175.  Terpinhydrate+ dextromethorphan + menthol
176.  dextromethorphan + phenylephrine + zinc gluconate+ menthol
177.  chlorpheniramine + codeine  + sodium citarte + menthol syrup
178.  Enrofloxacin + bromhexin
179.  Bromhexine  +Dextromethorphan  +Phenylephrine  +Menthol
180.  Levofloxacin  +Bromhexine
181.  Levocetirizine  +Ranitidine
182.  Levocetirizine +Phenylephrine +Ambroxol +Guaiphenesin +Paracetamol
183.  cetirizine  +  dextromethorphan  +  phenylephrine    +  zinc  gluconate  + paracetamol+ menthol
223.  Ambroxol  + Guaifenesin + Phenylephrine  + Chlorpheniramine
224.  Paracetamol +Phenylephrine  +Chlorpheniramine  +Zinc Gluconate
225.  Dextromethorphan +Phenylephrine +Cetirizine +Paracetamol +Caffeine
226.  Dextromethophan    +Chlorpheniramine    +Guaifenesin  +Ammonium Chloride
227.  Levocetirizine  +Dextromethorphan +Zinc
228.  Paracetamol +Phenylephrine  +Levocetirizine +Caffeine
229.  Chlorpheniramine  +Ammonium Chloride +Sodium Chloride
230.  Paracetamol  +Dextromethorphan    +Bromhexine    +Phenylephrine +Diphenhydramine
231.  Salbutamol +Bromhexine  +Guaiphenesin +Menthol
232.  Chlorpheniramine +Ammonium Chloride +Noscapine +Sodium Citrate
233.  Cetirizine +Dextromethorphan  +Bromhexine  +Guaifenesin
234.  Diethyl Carbamazine  +Chlorpheniramine  +Guaifenesin
235.  Ketotifen  +Cetirizine
236.  Terbutaline  +Bromhexine  +Etofylline
237.  Ketotifen  +Theophylline
238.  Ambroxol  +Salbutamol  +Theophylline
239.  Cetirizine  +Nimesulide +Phenylephrine
240.  Chlorpheniramine +Phenylephrine+Paracetamol+Zinc Gluconate
241.  Acetaminophen+Guaifenesin+Dextromethorphan +Chlorpheniramine
242.  Cetirizine +Dextromethorphan +Phenylephrine +Tulsi
243.  Cetirizine +Phenylephrine +Paracetamol+Ambroxol +Caffeine
244.  Guaifenesin+Dextromethorphan
245.  Levocetirizine +Paracetamol +Phenylephirine  +Caffeine
246.  Caffeine +Paracetamol +Phenylephrine  + Chlorpheniramine
247.  Ketotifen  +Levocetrizine
248.  Paracetamol +Levocetirizine  +Phenylephirine  +Zinc Gluconate
249.  Paracetamol +Phenylephrine  +Triprolidine  +Caffeine
250.  Caffeine +Paracetamol +Phenylephrine  +Cetirizine
251.  Dextromethorphan  +Phenylephirine  +Guaifenesin

| 184.           | paracetamol+ pseudoephedrine + dextromethorphan + cetirizine                                                                                                           |
|----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 185.           | diphenhydamine + guaiphenesin + ammonium chloride + bromhexine                                                                                                         |
| 186.           | Chlorpheniramine +Dextromethorphan +Phenylephrine +Paracetamol                                                                                                         |
| 187.           | Dextromethorphen +Promethazine                                                                                                                                         |
| 188.           | Diethylcabamazine +Cetrizine +Guaiphenesin                                                                                                                             |
| 189.           | Pseudoephedrine+Dextromethorphan +Cetirizine                                                                                                                           |
| 190.           | Chlorpheniramine +Phenylephrine +Dextromethophan +Menthol                                                                                                              |
| 191.           | Ambroxol + Terbutaline + Dextromethorphan                                                                                                                              |
| 192.           | Dextromethorphan +Chlorpheniramine +Guaiphenesin                                                                                                                       |
| 193.           | Terbutaline +Bromhexine +Guaiphenesin+Dextromethorphan                                                                                                                 |
| 194.           | Dextromethorphan +Tripolidine +Phenylephirine                                                                                                                          |
| 195.           | Paracetamol +Dextromethorphan +Chlorpheniramine                                                                                                                        |
| 196.           | Pholcodine+Phenylephrine +Promethazine                                                                                                                                 |
| 197.           | codeine + levocetirizine + menthol                                                                                                                                     |
| 198.           | dextromethorphan + ambroxol + guaifenesin + phenylephrine + chlorpheniramine                                                                                           |
| 199.           | Cetirizine +Phenylephrine + Dextromethorphan + Menthol                                                                                                                 |
| 200.           | Roxithromycin + Serratiopeptidase                                                                                                                                      |
| 201.           | Paracetamol +Phenylephrine +Triprolidine                                                                                                                               |
| 202.           | Acetaminophen+Loratadine+ambroxol +Phenylephrine                                                                                                                       |
| 203.           | Cetirizine +Acetaminophen+Dextromethorphan +Phenyephrine +Zinc gluconate                                                                                               |
| 204.           | Diphenhydramine +Guaifenesin +Bromhexine +Ammonium Chloride +Menthol                                                                                                   |
| 205.           | Chlopheniramine Maleate +Codeine syrup                                                                                                                                 |
| 206. 207. 208. | Cetirizine +Dextromethorphan +Zinc Gluconate +Menthol Paracetamol +Phenylephrine +Desloratadine+Zinc Gluconate +Ambroxol levocetirizine + montelukast + acebrophylline |
| 209.           |                                                                                                                                                                        |
| 210.           | dextromethorphan + phenylephrine + ammonium chloride + menthol Dextromethorphan +bromhexine +Guaiphenesin+menthol                                                      |
| 211.           | Acrivastine+ Paracetamol + Caffeine + Phenylephrine                                                                                                                    |
| 212.           | Naphazoline +carboxy Methyl cellulose +Menthol +Camphor +Phenylephrine                                                                                                 |
| 213.           | Dextromethorphan +Cetirizine                                                                                                                                           |
| 214.           | nimesulide + paracetamol + levocetirizine + phenylephrine + caffeine                                                                                                   |
| 215.           | Terbutaline +Ambroxol +Guaiphenesin+Zinc+Menthol                                                                                                                       |
| 216.           | Codeine +Chlorpheniramine +Alcohol syrup                                                                                                                               |
| 217.           | Dextromethorphan +Phenylephrine +Guaifenesin+Triprolidine                                                                                                              |
| 218.           | Ammomium Chloride+Bromhexine +Dextromethorphan Diethylcarbamazine +Cetirizine +Ambroxol                                                                                |
| 219.           | Ethylmorphine + Noscapine + Chlorpheniramine Maleate                                                                                                                   |
| 220. 221.      | Cetirizine +Dextromethorphan +Ambroxol                                                                                                                                 |
|                | +Menthol                                                                                                                                                               |
| 222.           | Bromhexine +Dextromethorphan +Ammonium Chloride                                                                                                                        |

252.  Ambroxol    +  Levocetirizine    +  Phenylephrine    +  Guaiphenesin  +

Menthol

253.  Pseudoephedrine  +Cetirizine
254.  Dextromethorphan +Chlorpheniramine +Ammonium Chloride +Menthol
255.  Paracetamol +Caffeine  +Phenylephrine  +Chlorpheniramine
256.  Salbutamol +Aminophylline +Guaifenesin
257.  Salbutamol +Thoephylline  +Bromhexine
258.  Chlorpheniramine +Dextromethorphan +Guaifenesin +Phenylephrine
259.  Caffeine + Paracetamol+ Chlorpheniramine
260.  Ammonium Chloride+Dextromethophan+Cetirizine +Menthol
261.  Dextromethorphan +Paracetamol+Cetirizine +Phenylephrine
262.  Chlorpheniramine +Terpin +Antimony Potassium Tartrate+Ammonium chloride+Sodium Citrate+Menthol
263.  Terbutaline Sulphate+Etofylline+Ambroxol
264.  Paracetamol +Codeine  +Chlorpheniramine
265.  Paracetamol +Pseudoephedrine  +Cetirizine  +Caffeine
266.  Chlorpheniramine  +Ammonium Chloride +Menthol
267.  N-Acetyl Cysteine + Ambroxol  + Phenylephrine  + Levocetirizine
268.  Dextromethorphan  +Phenylephrine +Tripolidine +Menthol
269.  Salbutamol +Cetirizine  +Ambroxol
270.  Dextromethorphan    +Phenylephrine    +Bromhexine    +Guaifenesin+ Chlorpheniramine
271.  Nimesulide +Cetirizine  +Phenylephrine
272.  Naphazoline +Chlorpheniramine +Zinc Sulphate +Boric Acid Ip+Sodium chloride +chlorobutol
273.  Paracetamol+Bromhexine +Phenylephrine +Chlorpheniramine +Guaifenesin
274.  Salbutamoll+Bromhexine
275.  Dextromethorphan +Phenylephrine +Guaifenesin +Cetirizine +Acetaminophen
276.  Guaifenesin+ Bromhexine + Chlorpheniramine + Paracetamol
277.  Chlorpheniramine  +Ammonium Chloride +Chloroform +Menthol
278.  Salbutamol  +Choline Theophylinate +Ambroxol
279.  Chlorpheniramine  +Codeine phosphate +Menthol  syrup
280.  Pseudoephedrine  +Bromhexine
281.  Cetirizine  +Phenylephrine  +Paracetamol +Caffeine +Nimesulide
282.  Dextromethorphan  +Cetirizine  +Guaifenesin +Ammonium Chloride
283.  Ambroxol  + Salbutamol  + Choline Theophyllinate + Menthol
284.  Paracetamol +Chlorpheniramine +Ambroxol +Guaifenesin +Phenylephrine
285.  Chlorpheniramine    +Vasaka    +Tolubalsm  +Ammonium  Chloride +Sodium Citrate +Menthol
286.  Bromhexine  +Cetrizine  +Phenylephrine  +Guaifenesin +Menthol
287.  Dextromethorphan +Ambroxol +Ammonium Chloride +Chlorpheniramine  +Menthol
288.  Dextromethorphan  +Phenylephrine +Cetirizine  +Zinc +Menthol
289.  Terbutaline  + N-Acetyl L-Cysteine + Guaifenesin
290.  Calcium Gluconate +Levocetirizine
291.  Paracetamol +Levocetirizine+Pseudoephedrine
292.  Salbutamol  +Choline Theophylinate +Carbocisteine
293.  Chlorpheniramine +Vitamin C
294.  Calcium Gluconate +Chlorpheniramine  +Vitamin C
295.  Chlorpheniramine+Paracetamol +Pseudoephedrine  +Caffeine
328.  Albuterol + Etofylline + Bromhexine  + Menthol
329.  Albuterol + Bromhexine  + Theophylline
330.  Salbutamol + Hydroxyethyltheophylline  (Etofylline)+ Bromhexine
331.  Paracetamol +Phenylephrine  +Levocetirizine  +Sodium  Citrate
332.  Paracetamol +Propyphenazone +Caffeine
333.  Guaifenesin +Diphenhydramine  +Bromhexine  +Phenylephrine
334.  Dried Alumnium Hydroxide Gel +Propantheline Bromide +Diazepam
335.  Bromhexine  +Phenylephrine +Chlorpheniramine  +Paracetamol
336.  Beclomethasone +Clotrimazole+Gentamicin+IodoChlorhydroxyquinoline
337.  Telmisartan + Metformin
338.  Ammonium Citrate+Vitamin B 12+Folic Acid+Zinc Sulphate
339.  levothyroxine  pyridoxine+ nicotinamide
340.  benfotiamine+ metformin
341.  Thyroid +Thiamine + Riboflavin + Pyridoxine + Calcium Pantothenate + Tocopheryl Acetate +Nicotinamide
342.  Ascorbic  Acid    +  Manadione  Sodium  Bisulphate+  Rutin  +  Dibasic Calcium Phosphate  + Adrenochrome Mono Semicarbazone
343.  Phenylephrine +Chlorpheniramine +Paracetamol +Bromhexine +Caffeine
344.  Clotrimazole  +Beclomethasone    +Lignocaine    +Ofloxacin  +Acetic Acid + Sodium Methyl Paraben +Propyl Paraben

| 296.      | Guaifenesin +Bromhexine +Chlorpheniramine +Phenylephrine +Paracetamol +Serratiopeptidase (as enteric coated granules)10000 SP Units   |
|-----------|---------------------------------------------------------------------------------------------------------------------------------------|
| 297.      | Paracetamol +Pheniramine                                                                                                              |
| 298.      | Betamethasone +Fusidic Acid+Gentamycin +Tolnaftate+Iodochlorhydroxyquinoline(ICHQ)                                                    |
| 299.      | Clobetasol +Ofloxacin+Miconazole +Zinc Sulphate                                                                                       |
| 300.      | Clobetasole +Gentamicin +Miconazole +Zinc Sulphate                                                                                    |
| 301.      | levocetirizine + ambroxol + phenylephrine + paracetamol                                                                               |
| 302.      | Permethrin + Cetrimide + Menthol                                                                                                      |
| 303.      | beclomethasone + clotimazole + neomycin + iodochlorohydroxyquinone                                                                    |
| 304.      | Neomycin + Doxycycline                                                                                                                |
| 305.      | Ciprofloxacin + Fluocinolone + Clotrimazole + Neomycin + Chlorocresol                                                                 |
| 306. 307. | Clobetasol + Ofloxacin + Ketoconazole + Zinc Sulphate Betamethasone +Gentamicin +Tolnaftate +Iodochlorhydroxyquinoline                |
| 308.      | Clobetasol +Gentamicin +Tolnaftate +Idochlorhydroxyquinone +Ketoconazole                                                              |
| 309. 310. | Allantoin+Dimethieone+Urea+Propylene+Glycerin+Liquid paraffin Acriflavine +Thymol+Cetrimide                                           |
| 311. 312. | Betamethasone +Neomycin +Tolnaftate +Iodo Chloro Hydroxy Quinoline +Cholorocresol clobetasol +Neomycin +Miconazole +Clotrimazole      |
| 313.      | Ketoconazole+Tea Tree oil+Allantion+zinc Oxide+Aloe Vera+Jojoba oil+Lavander oil+Soap noodles                                         |
| 314. 315. | Clobetasol +Ofloxacin +Ornidazole +Terbinafine Clobetasol +Neomycin +Miconazole +Zinc Sulphate Beclomethasone+Neomycin +Tolnaftate    |
| 316.      | +Iodochlorhydroxyquinoline +Chlorocresol                                                                                              |
| 317.      | Betamethasone +Gentamycin +Zinc Sulphate +Clotrimazole +Chlorocresol                                                                  |
| 318.      | "Borax +Boric acid +Naphazoline +Menthol +Camphor + methyl hydroxy benzoate                                                           |
| 319.      | Bromhexine +Dextromethorphan Dextromethophan +Chlopheniramine +Bromhexine "Menthol +Anesthetic Ether                                  |
| 320.      |                                                                                                                                       |
| 321.      |                                                                                                                                       |
| 322.      | Dextrometharphan +Chlopheniramine +Ammonium Chloride +Sodium Citrate +Menthol                                                         |
| 323.      | Ergotamine Tartrate +Belladona dry extract +Caffeine +Paracetamol                                                                     |
|           | Phenytoin +Phenobarbitone sodium                                                                                                      |
|           | Paracetamol + Ambroxol + Phenylephrine +Chlorpheniramine                                                                              |
| 327.      | + Ornidazole suspension                                                                                                               |
|           | Ofloxacin                                                                                                                             |
| 326.      |                                                                                                                                       |
| 325.      | Gliclazide 40mg+Metformin 400mg                                                                                                       |
| 324.      |                                                                                                                                       |