opendatalab/WebMainBench huggingface dataset:
# Uveal melanoma: a promising avenue for treating metastatic forms

Up to 50% of patients suffering from uveal melanoma, a rare cancer of the eye, die from metastasis from the disease. Thus we urgently need to find new therapeutic approaches.

Uveal melanoma is the most common form of eye cancer in adults, with 500 to 600 new cases diagnosed in France every year. As long as the tumour is localised, the treatments currently available - including surgery, protontherapy and curietherapy - limit the risk of local recurrence in ten years to 5%. However, as soon as the disease has spread through metastasis, usually to the liver, which happens to one patient in three, the prognosis is compromised. “**So far no treatment has proven truly effective in terms of survival to treat metastatic forms of the disease** ,” explains Dr Sophie Piperno-Neumann, clinical oncologist at Institut Curie and a specialist in this pathology. Although therapeutic options targeting PKC have generated some optimism, this is not enough.” The doctors and researchers at Institut Curie therefore had the idea to combine therapies targeted on other pathways, often disrupted in this type of cancer, with a PKC inhibitor (AEB071).

**“The result was beyond all of our hopes, since these combinations were effective in the 5 preclinical models representative of the different types of uveal melanoma at our disposal.** Two combinations - PKC inhibitor associated with either a p53-MDM2 inhibitor or a mTORC1 inhibitor - seem to be especially promising”, explains Dr Didier Decaudin, clinical oncologist, manager of the preclinical investigation laboratory. These two combinations have proven their effectiveness in cultured cell lines.

**“The dual inhibition of PKC and p53-MDM2 or mTORC1 is the most effective of the therapeutic combinations tested on our preclinical models and represents hope for the treatment of metastatic forms of uveal cancer”,** adds Dr Sophie Piperno-Neumann. “We now have sufficient evidence to support these combinations to begin clinical trials in patients.”

### **Find out more**

"Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma"  
Guillaume Carita, Estelle Frisch-Dit-Leitz, Ahmed Dahmani, Chloé Raymondie, Nathalie Cassoux, Sophie Piperno-Neumann, Fariba Némati, Cécile Laurent, Leanne De Koning, Ensar Halilovic, Sebastien Jeay, Andrew Wylie, Caroline Emery, Sergio Roman-Roman, Marie Schoumacher, Didier Decaudin  
 _Oncotarget_

En savoir plus

Uveal melanoma

Uveal melanoma is the most common form of eye cancer in adults, with 500 to 600 new cases diagnosed each year in France…
# The 'DACA kids' aren't kids anymore. For many, that's a mixed blessing.

As the Supreme Court decides whether to toss out the Obama-era program, one DACA recipient shares her struggle with the uncertainty. 

PHOENIX — They're often called "DACA kids." But in most cases, they're not kids anymore, even though they were brought to the United States as children. 

And Deferred Action for Childhood Arrivals, the Obama-era program shielding these undocumented immigrants from deportation, has been a mixed blessing.

"You can make a life after DACA only for two years," said 32-year-old Susana Nava, who qualified for the deferred action program when she was 25.

The $500 DACA work permit lasts two years before it has to be renewed. But there are no guarantees.

"I can't really expect to go into a relationship and have a family because I don't know what's going to happen two years from now."

As the U.S. Supreme Court considers whether to uphold President Donald Trump's order tossing out DACA, stories like Nava's provide a window on the unsettled lives of recipients, many of them in their 20s and 30s.

Nava gave up on her dream of becoming a school teacher after graduating from high school in the pre-DACA era. 

"I looked out and I didn't really have where to go to," she said.

Now working as a loan officer, Nava's biggest dreams are for her 17-year-old sister, who was born in the U.S.

Nava is saving to send her to the college that she couldn't attend after high school.

"That's my hope: that what my parents sought out for me, that I'm able to provide that for my little sister," she said. 

The U.S. Supreme Court's decision on the fate of DACA is expected sometime in spring 2020.
**Glen Rice commits to Georgia Tech**  
| **ORLANDO** \- An already impressive 2009 recruiting class for the [tm]Georgia Tech[/tm] Yellow Jackets just got a little bit better on Thursday when Glen Rice issued his commitment. Rice becomes the fourth commitment for Coach Paul Hewitt's squad.  
Rice was solid in the Georgia Stars opening game win over the St. Louis Eagles, and after the game he made an anticipated announcement. "I am committing to Georgia Tech," Rice explained.  
  
For Rice the reasons for committing to the Yellow Jackets were numerous. "It is close to home, I really like the environment, and I really like the coaches. Also they have (Kammeon Holsey) going there.  
  
Earlier this week four-star point guard Mfon Udofia committed to the Yellow Jackets joining Holsey and _Rivals.com_ top 150 prospect Brian Oliver. Rice, the No. 46 rated player in the country, feels that the recruiting class that Hewitt and company are bringing in could be special.  
  
"It is a really big class, it is really good," said Rice about the impressive four man class that now boasts four of the top 125 players in the country.  
  
With his college decision out of the way Rice will now try to help his team to a Super Showcase title in Orlando.  
  
---
#  Can You Win Big Against The House With Blindfold Video Poker for iOS?

In this podcast, AnonyMouse gives us a walk-through and demonstration of Blindfold Video Poker for iOS.

Created by the authors of Blindfold Racer, Blindfold Blackjack and Blindfold Solitaire, this game is designed for rapid audio play, and is fully accessible without need of VoiceOver.

Blindfold Video Poker is a free download from the iTunes App Store
# ATTN PARALLELS DEVS: IMPLEMENTED: NixOS support via Parallels Tools 16 under Linux kernel 5.9

  1. > Parallels developers, please add the following support to Parallels 16 via the following patch was created by Weijia Wang (wegank). Ticket:   
> https://github.com/NixOS/nixpkgs/issues/31882#issuecomment-753131827  
>   
>  Patch: https://github.com/wegank/nixos-config/tree/main/hardware/parallels-unfree

  2. > In addition, I suggest removing all hard-coded paths in binaries and shared objects bundled in Parallels Tools. Since NixOS is not FHS-compliant and all packages, including system executables, are stored in /nix/store/, hard-coded paths like /usr/bin/* will never work.   
>   
>  As a disclaimer, the Nix package uses GalaxyMaster's patch for kernel versions greater than 5.8.
# USCAA Div 1 Championship Game

UNIONTOWN, PA – For the fifth time in school history the Rochester College Warriors have won the USCAA Men’s Division I basketball National Championships. Rochester College defeated the Daemen College Wildcats 70-67. Led by the dominant inside duo of Dramel Hogan and Drew Maynard, a Rochester team that hasn’t lost since December 8th captured their first basketball National Championship since 2004-2005. Read More: http://uscaabasketball.prestosports.com/2013_Championships/Rochester_College_Win

  *   *   *   *   *   *   *   *   *   *   *   *   *   *   *   *   *   *   *   *
# Keep Moving with Goal Zero Rechargers

**Tahoe Mountain Sports is proud to carry solar panels and solar-powered gadgets byGoal Zero. Charge your laptop, phone, audio device, batteries and other electronics while in the field with your own portable power device.**

Since Goal Zero became a company in June of 2009 their mission has been to empower people by putting reliable power in the hands of every human being. As they’ve grown over the years their mission has stayed the same and they’ve been lucky enough to connect with people around the world. They’ve been amazed by the steady flow of stories we receive about the good that our friends around the world are doing. In order to help share these stories they’ve created Solar Life.

Solar Life is about the feeling you get waking up to a frost-encrusted tent before dawn. It’s hiking a high mountain ridge to watch the sun rise. It’s bringing light into the lives of those in need, but most of all it’s having the freedom to get out and stay out doing the things that you love without compromising. Solar Life exists to capture and share the stories of those seeking adventure and empowering others. These stories come from their ambassadors, employees and, most importantly, you.

Whether you’re at base camp for months, camping in your backyard, or serving your community, these stories are for you. Goal Zero hope they inspire, empower, and help you live a Solar Life of your own.
> Scotsman (Sport): A perfect ten for Capital clubs as they target Scottish Cup glory

View Full Version : Scotsman (Sport): A perfect ten for Capital clubs as they target Scottish Cup glory

  


30-11-2011, 10:25 AM

Whitson STAR became the tenth Capital club to reach the fourth round of the Scottish Amateur Cup for Saturday clubs when beating Cowie Thistle 2-0.
**Edinburgh Suburban and Southside Junction Railway** This line is open to freight.  
---  
---  
  
**Local area**

This line runs through the south of Edinburgh.

**Chronology**

The line was opened by the North British Railway as a suburban passenger route and freight bypass for central Edinburgh and useful second link from the west of the city to the east. It is still in use for diversions and freight but the stations along the route have closed.

**Description of route**

From Haymarket to Duddingston.

Haymarket West Junction  
(Edinburgh and Glasgow Railway

Haymarket Central Junction  
(Edinburgh and Glasgow Railway

**Gorgie Junction**

  
Gorgie junction complete with signalbox.  
---  
  
This south facing junction is the south junction of the triangular junction at Haymarket. Lines from Haymarket East Junction and Haymarket West Junction meet here.

Gorgie

Slateford Junction (New)  
(This connects to the Caledonian Railway. The connection was put in by British Railways

Craiglockhart Junction  
(This is the start of the connection to the Caledonian Railway. The connection was put in by British Railways.) 

**Craiglockhart**

  
Craiglockhart looking south.  
---  
  
This closed station had two platforms.

**Morningside Road**

  
8598 and 8528 pass Morningside on 20/07/1971. |    
1975 with a westbound freight on 20 July 1971\.   
---|---  
  
This closed station had two platforms.

Blackford Hill

**Newington**

  
The former Newington station.  
---  
  
This closed station had an island platform.

Duddingston

Duddingston Junction  
Edinburgh and Dalkeith Railway
##  › Teens

##  Mentoring high performing, low income students 

Minds Matter is recruiting our next class of college access mentors to help high-performing, low-income high school students build the skills, tools, and experience they need to earn college acceptance and scholarships. Minds Matter is on a mission to ensure that ability, not access, determines post-secondary academic success for Denver high school students. Our program connects high-performing students from low-income families with the relationships and resources they need to achieve their academic potential. For compassionate, engaged, community-oriented adults who are…

##  Write & Talk for Teens with Lighthouse Writers Workshop 

4:00pm – 6:00pm Are you interested in exploring the world of creative writing? Join local author Whitney Gaines to try a new genre or topic each month. Registration Required!
##  "Rapid Rig: Advanced" - Auto Rig for Maya 2.1.3 (maya script) 

This is a tool that will set up a customizable rig for a bipedal character

  *   *   *   *   *   *   *   * 


#### License Type:

Commercial

#### Price:

$40.00 (USD)   
---  
  
#### File ID:

15468 | 

#### File Size:

131.8 KB  
  
#### Platforms:

linux, mac, windows  
  
#### Maya:

2008, 2009, 9.x, 2010, 2011, 2012, 2013  
  
The single hierarchy is completely driven by the rest of the rig using constraints. This was the best method that I could come up with that would make exporting to an engine the easiest, and still maintaining almost the same level of control that the original joint hierarchy has.

What I recommend is once you are ready to export your rig, select all the single hierarchy joints, then bake animation. This will add keys to all your joints. Then, delete all the constraints on the joints. At this point, the single hierarchy rig should have zero dependencies to the rest of the rig.

If this doesn't seem sufficient, let me know and I can maybe add some additional functionality to the UI that will streamline exporting.

Thanks for the prompt response. The overhead in the engine caused by this rig is not really enough to worry about overall, the game engine bakes in the animation into the mesh upon import, I was just thinking if it was a simple addition or fix then great if not then it is not the end of the world either. It would just help maintain a cleaner workspace in the engine. 

Are you exporting the entire rig to the engine, or just the single hierarchy? Or is it baking the animation to each vertex of the mesh?

The engine reads the raw maya file and treats it like an FBX, baking in the animation into the mesh when this option is enabled. When the maya file is altered it will re-import. However in the files hierarchy in the engine it shows all of the nodes and rig group data. Stripping that out will decrease overhead. However baking in animation does minimize the overhead anyway, so in the end it is not a HUGE deal to remove the underlying rig. I was just wondering if it was something feasible.

However with a little more playing around I am sure I will get the setup to work as I want it to. Loving it so far.

That's interesting, sounds like it has a great tie-in with Maya for workflow. I can understand why you would want something more stripped down in that case. Originally when I wrote this script, it wasn't designed with games in mind, but I received a lot of requests for it, so it was kind of an afterthought.

Game engines are a huge can of worms, because there are so many out there that require a unique workflow. So doing something that works really great for one game engine, may not counter intuitive for another.

It's definitely something I will keep in mind though, for future updates :)
椰油醇/巴巴苏油醇/安迪拉巴醇硫酸酯钠

**用途及示例配方**

**（一）****典型用途**

作为去污剂应用。

作为发泡剂应用。

**（二）****个人护理用品**

作为去污剂等应用。

**（三）、家用洗涤剂**

作为去污剂、发泡剂等应用。

**（四）、工业清洗剂**

作为去污剂等应用。

**（五）、乳液聚合**

作为乳化剂、粒度控制剂等应用。

**（六）、宠物**

作为去污剂、发泡剂主成分或辅助成分，应用于宠物香波等产品中。
|  |  **The Ajna Offensive** has set a January 22 international release date for **HEAD OF THE DEMON** 's self-titled debut album.   
  
A mysterious Swedish entity comprising nameless members from known bands, **HEAD OF THE DEMON** 's first CD is a sepulchral, doom-laden slab of occult black/death metal that's Lovecraftian in intent and aims for the abyss.   
  
A press release states: "**H.P. Lovecraft** is an inexhaustible source of inspiration for those who play metal, and tributes to the great visionary of Providence have been countless. **HEAD OF THE DEMON** are ones who have seen the faces of the Great Old Ones, yet all but eschew the usual clichés based upon tentacles and unspeakable horrors. Their occult black/death metal is hypnotic and honed, played mainly on the rawness of riffs and chants that are repeated cyclically. Psychedelic vertigo is assured, and with it the stimulation of perceptions that open windows to mysterious parallel dimensions. The voice sounds like that of **Tom Warrior** mentally dissociated under acid, while the guitars constantly seek ways of expressive, original, yet oblique metal without foresaking metal altogether. The long ramblings of **'Phantasmagoria'** and **'They Lie In Wait - Riding The Waste'** creep ominously between proto-doom **BLACK SABBATH** -ian realms and the atmosphere of Mortuary Drape's cenotaph, never fully enjoying one or the other. The key, however, is the ancient and mysterious sound of an organ, which gives additional character to such ritualistic music, making the result extremely gruesome. **HEAD OF THE DEMON** realize that in order to see the true horror and the unfathomable depths narrated by Lovecraft, you do not need to travel to the edge of the cosmos: just look in our own head...in the demon's head.  
  
**"Head Of The Demon"** track listing:  
  
01\. **By Titan Hand** (6:30)   
02\. **The Lie In Wait - Riding The Waste** (9:22)  
03\. **Phantasmagoria** (5:48)   
04\. **The Man From Foreign Land** (6:51)  
05\. **The Key** (6:22)  
06\. **Fifth House Of The Mausoleum** (8:18)  
07\. **Wraith From The Unknown** (7:54)  
  
  
---
# Regrets about sex may depend on your gender - KTVN Channel 2 - Reno Tahoe News Weather, Video - 

TUESDAY, Nov. 26, 2013 (HealthDay News) -- If remorse over sex strikes a man or a women, he'll likely regret a lost opportunity while she'll fret over a one-night stand, a new study shows.

The researchers say the findings make evolutionary sense.

"For men throughout evolutionary history, every missed opportunity to have sex with a new partner is potentially a missed [reproductive] opportunity -- a costly loss from an evolutionary perspective," study leader Martie Haselton explained in a University of Texas at Austin news release.

"But for women, reproduction required much more investment in each offspring, including nine months of pregnancy and potentially two additional years of breast-feeding," said Haselton, who is a social psychology professor at the University of California, Los Angeles. "The consequences of casual sex were so much higher for women than for men, and this is likely to have shaped emotional reactions to sexual liaisons even today."

In the study, Haselton's team surveyed nearly 25,000 heterosexual, bisexual, gay and lesbian Americans, and found that the top three most common sexual regrets for men were: being too shy to make a move on a prospective sexual partner (27 percent); not being more sexually adventurous when young (23 percent); and not being more sexually adventurous during their single days (19 percent).

For women, the top three regrets were: losing their virginity to the wrong partner (24 percent); cheating on a present or past partner (23 percent); and moving too fast sexually (20 percent).

More women than men (17 percent vs. 10 percent) listed having sex with a "physically unattractive partner" as a top regret, according to the study published in the 

Rates of engaging in casual sex were similar overall among participants (56 percent), but women in all groups (heterosexual, bisexual and lesbian) had more frequent and intense regrets about it.

Haselton said that differences in men's and women's reaction to sex seem to endure over millennia, even though the context in which people have sex may have changed.

"For example, we have reliable methods of contraception," she said. "But that doesn't seem to have erased the sex differences in women's and men's responses, which might have a deep evolutionary history."
# NCHSAA sets changes for football, soccer

The North Carolina High School Athletic Association made several changes regarding football and soccer at a meeting earlier in the week.

Those changes will go into effect for the 2020 season.

In football, the total amount of scrimmage time will drop from 7 to 5 hours and there a 48-hour gap between scrimmages is required. But that gap would not apply to teams participating in a multi-session jamboree.

Also, during the first official week of practice, live contact between players will be limited. During that period, live contact is limited to 15 minutes per day per position group. That limitation becomes 15 per week once the regular season begins.

“I’m fine with it,” said North Davidson coach Brian Flynn. “At the end of the day, when it comes full circle, it’s about player safety and things like that.”

It probably won’t change the overall approach of teams as they prepare for the season.

“We just have to adjust to what they tell us we can do,” said West Davidson coach Bryan Lingerfelt.

Tweaking how practices are run is an ongoing process for coaches anyway.

“When we manage practice we figure how much what we call ’bang’ time that we have,” Flynn said. “...How much is enough? You don’t want anyone to get hurt. That’s the last thing you want to do.”

Beginning in 2021, the NCHSAA will also limit contact drills known as “bumps” during spring practice. That kind of contact will be allowed for a total of 60 minutes between April 15 until the last 10 days of school. Such activity is not permitted at any other time in the spring or at all during the summer.

Bumps are physical activity that don’t result in players being tackled or otherwise knocked to the ground.

The big change in soccer is the elimination of shoot-outs to break ties in regular season games. It’s a ruling which could prove popular, at least among coaches.

“Personally, I’m glad we’re not going to go to shootouts in regular season games anymore,” said Central Davidson coach Chad Hench. “Shootouts are something that should be used for tournament progression where you have to have a winner. I know most people don’t like soccer to end in a tie. But it has been an aspect of soccer since the game’s inception.”

Hench feels a shootout can skew the result of a game.

“You can have the better team and the lesser team can win the shootout and manage to sneak out a win,” he said.

If the teams are tied after two 10-minute overtime periods, the contest ends in a draw.

The NCHSAA also changed the playoff calendar, with early-round soccer games on Monday and Thursday.