# Tlr3 Publications

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Honda K, et al.  
Mouse over for full list | (2003) | Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. | Proc. Natl. Acad. Sci. U.S.A. 100(19):10872-7 | Virology  
Andoniou CE, et al.  
Mouse over for full list | (2005) | Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. | Nat. Immunol. 6(10):1011-9 | NK  
Meylan E, et al.  
Mouse over for full list | (2004) | RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. | Nat. Immunol. 5(5):503-7  
Heil F, et al.  
Mouse over for full list | (2004) | Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. | Science 303(5663):1526-9  
De Filippo K, et al.  
Mouse over for full list | (2008) | Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways. | J. Immunol. 180(6):4308-15  
Johnson AC, et al.  
Mouse over for full list | (2008) | MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase. | J. Biol. Chem. 283(7):3988-96  
Gasse P, et al.  
Mouse over for full list | (2007) | IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. | J. Clin. Invest. 117(12):3786-99 | Inflammation  
Togbe D, et al.  
Mouse over for full list | (2007) | Murine cerebral malaria development is independent of toll-like receptor signaling. | Am. J. Pathol. 170(5):1640-8  
Akazawa T, et al.  
Mouse over for full list | (2007) | Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells. | Proc. Natl. Acad. Sci. U.S.A. 104(1):252-7  
Takami M, et al.  
Mouse over for full list | (2002) | Stimulation by toll-like receptors inhibits osteoclast differentiation. | J. Immunol. 169(3):1516-23  
Flandin JF, et al.  
Mouse over for full list | (2006) | RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by interferon-gamma-primed macrophages. | Eur. J. Immunol. 36(2):411-20  
Beutler B  
Mouse over for full list | (2005) | The Toll-like receptors: analysis by forward genetic methods. | Immunogenetics 57(6):385-92  
Gitlin L, et al.  
Mouse over for full list | (2006) | Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. | Proc. Natl. Acad. Sci. U.S.A. 103(22):8459-64 | Immunology, Virology  
Jiang D, et al.  
Mouse over for full list | (2005) | Regulation of lung injury and repair by Toll-like receptors and hyaluronan. | Nat. Med. 11(11):1173-9  
Shim JH, et al.  
Mouse over for full list | (2005) | TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. | Genes Dev. 19(22):2668-81  
Wang T, et al.  
Mouse over for full list | (2004) | Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. | Nat. Med. 10(12):1366-73 | Virology  
Schulz O, et al.  
Mouse over for full list | (2005) | Toll-like receptor 3 promotes cross-priming to virus-infected cells. | Nature 433(7028):887-92 | Virology  
Punturieri A, et al.  
Mouse over for full list | (2004) | Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages. | J. Immunol. 173(2):1033-42  
Yamamoto M, et al.  
Mouse over for full list | (2003) | Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. | Science 301(5633):640-3  
Greidinger EL, et al.  
Mouse over for full list | (2006) | A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen. | Arthritis Rheum. 54(2):661-9  
Lafon M, et al.  
Mouse over for full list | (2008) | Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis. | J. Immunol. 180(11):7506-15 | Virology  
Tesar BM, et al.  
Mouse over for full list | (2006) | The role of hyaluronan degradation products as innate alloimmune agonists. | Am. J. Transplant. 6(11):2622-35  
Dogusan Z, et al.  
Mouse over for full list | (2008) | Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways. | Diabetes 57(5):1236-45  
Wang X, et al.  
Mouse over for full list | (2007) | Upregulation of macrophage endothelial lipase by toll-like receptors 4 and 3 modulates macrophage interleukin-10 and -12 production. | Circ. Res. 100(7):1008-15  
Kleinman ME, et al.  
Mouse over for full list | (2008) | Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. | Nature 452(7187):591-7  
Yount JS, et al.  
Mouse over for full list | (2008) | MDA5 participates in the detection of paramyxovirus infection and is essential for the early activation of dendritic cells in response to Sendai Virus defective interfering particles. | J. Immunol. 180(7):4910-8 | Virology  
Zhou S, et al.  
Mouse over for full list | (2008) | Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses. | J. Neuroimmunol. 194(1-2):70-82 | Virology  
Savarese E, et al.  
Mouse over for full list | (2006) | U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7. | Blood 107(8):3229-34  
Hutchens M, et al.  
Mouse over for full list | (2008) | TLR3 increases disease morbidity and mortality from vaccinia infection. | J. Immunol. 180(1):483-91 | Vaccine Research  
Town T, et al.  
Mouse over for full list | (2006) | Microglia recognize double-stranded RNA via TLR3. | J. Immunol. 176(6):3804-12  
Mallevaey T, et al.  
Mouse over for full list | (2006) | Activation of invariant NKT cells by the helminth parasite schistosoma mansoni. | J. Immunol. 176(4):2476-85  
Sugiyama T, et al.  
Mouse over for full list | (2008) | Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7. | Int. Immunol. 20(1):1-9  
Cameron JS, et al.  
Mouse over for full list | (2007) | Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. | J. Neurosci. 27(47):13033-41  
Rudd BD, et al.  
Mouse over for full list | (2006) | Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection. | J. Immunol. 176(3):1937-42  
Johansson C, et al.  
Mouse over for full list | (2007) | Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus. | J. Exp. Med. 204(6):1349-58  
Craxton A, et al.  
Mouse over for full list | (2007) | Bim regulates BCR-induced entry of B cells into the cell cycle. | Eur. J. Immunol. 37(10):2715-22  
Chen CJ, et al.  
Mouse over for full list | (2007) | Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. | Nat. Med. 13(7):851-6  
Marshall-Clarke S, et al.  
Mouse over for full list | (2007) | Polyinosinic acid is a ligand for toll-like receptor 3. | J. Biol. Chem. 282(34):24759-66  
Wallace A, et al.  
Mouse over for full list | (2007) | The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes. | Cancer Res. 67(14):7011-9  
Hardarson HS, et al.  
Mouse over for full list | (2007) | Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. | Am. J. Physiol. Heart Circ. Physiol. 292(1):H251-8  
Delale T, et al.  
Mouse over for full list | (2005) | MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo. | J. Immunol. 175(10):6723-32  
Hensley SE, et al.  
Mouse over for full list | (2005) | Dendritic cell maturation, but not CD8+ T cell induction, is dependent on type I IFN signaling during vaccination with adenovirus vectors. | J. Immunol. 175(9):6032-41  
Rothenfusser S, et al.  
Mouse over for full list | (2005) | The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. | J. Immunol. 175(8):5260-8  
Okabe Y, et al.  
Mouse over for full list | (2005) | Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. | J. Exp. Med. 202(10):1333-9  
Kanneganti TD, et al.  
Mouse over for full list | (2006) | Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. | J. Biol. Chem. 281(48):36560-8  
Yang X, et al.  
Mouse over for full list | (2006) | Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells. | Am. J. Physiol. Heart Circ. Physiol. 291(5):H2334-43  
Matsumoto M, et al.  
Mouse over for full list | (2002) | Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. | Biochem. Biophys. Res. Commun. 293(5):1364-9  
Howell MD, et al.  
Mouse over for full list | (2006) | Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. | Immunity 24(3):341-8  
Nishiya T, et al.  
Mouse over for full list | (2005) | TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. | J. Biol. Chem. 280(44):37107-17  
Christensen SR, et al.  
Mouse over for full list | (2005) | Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. | J. Exp. Med. 202(2):321-31  
Kamath AT, et al.  
Mouse over for full list | (2005) | Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma. | J. Immunol. 174(2):767-76  
Matsushima H, et al.  
Mouse over for full list | (2004) | TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells. | J. Immunol. 173(1):531-41  
Gelman AE, et al.  
Mouse over for full list | (2004) | Toll-like receptor ligands directly promote activated CD4+ T cell survival. | J. Immunol. 172(10):6065-73  
Zare F, et al.  
Mouse over for full list | (2004) | Arthritogenic properties of double-stranded (viral) RNA. | J. Immunol. 172(9):5656-63  
Edelmann KH, et al.  
Mouse over for full list | (2004) | Does Toll-like receptor 3 play a biological role in virus infections? | Virology 322(2):231-8  
Tabeta K, et al.  
Mouse over for full list | (2004) | Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. | Proc. Natl. Acad. Sci. U.S.A. 101(10):3516-21  
Hoebe K, et al.  
Mouse over for full list | (2003) | Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. | Nat. Immunol. 4(12):1223-9  
Applequist SE, et al.  
Mouse over for full list | (2002) | Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines. | Int. Immunol. 14(9):1065-74  
Alexopoulou L, et al.  
Mouse over for full list | (2001) | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. | Nature 413(6857):732-8  
Carninci P, et al.  
Mouse over for full list | (2005) | The transcriptional landscape of the mammalian genome. | Science 309(5740):1559-63  
Okazaki Y, et al.  
Mouse over for full list | (2002) | Analysis of the mouse transcriptome based on functional annotation of 60, 770 full-length cDNAs. | Nature 420(6915):563-73  
Chen CJ, et al.  
Mouse over for full list | (2006) | MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. | J. Clin. Invest. 116(8):2262-71