opendatalab/WebMainBench huggingface dataset:
# House of Marley のヘッドフォン「POSITIVE VIBRATION XL ANC」が新登場

素材と環境に配慮した製品を作り展開するHouseofMarleyのPOSITIVEVIBRATIONシリーズから、ハイブリッドアクティブノイズキャンセレーションを採用した**「POSITIVEVIBRATIONXLANC」** が9月17日(金)に発売します。

従来モデル同様、FSC©認定木材や、リサイクル加工によって作られたアルミニウム、REWINDTMファブリックなどサステナブルな素材を使用。40mmのハイデフィニションドライバーを内蔵し、パワフルでバランスの取れたサウンドを再生します。1回の充電で最大26時間の連続再生(ANCオン)、クイックチャージ機能により約10分の充電で約2時間の音楽再生が可能です。また、メモリーフォーム・イヤークッションやヘッドバッドにより長時間リラックスして音楽を聴くことが出来ます。

**主な特徴**  
●アクティブノイズキャンセリング  
ハイブリッドノイズキャンセレーションを採用。静寂の中で好きな音楽やポッドキャストを楽しむことが可能です。  
●デザイン&スタイル  
FSC©認定木材や、リサイクル加工によって作られたアルミニウム、REWINDTMファブリックなどサステナブルな素材を使用。  
●充電  
1回の充電で最長26時間の連続再生が可能(アクティブノイズキャンセリング利用時)。また、クイックチャージ機能により約10分の充電で約2時間の再生が可能。  
●サウンド  
40mmのハイデフィニションドライバーを内蔵し、パワフルでバランスの取れたサウンドを再生。  
●快適性  
長時間リラックスして音楽を聴いていられるよう、メモリーフォーム・イヤークッション・ヘッドバッドを採用。  
●コントロール  
オンボードのマイクを搭載。ハンズフリー通話、音量調節、曲送り、SiriやGoogleアシスタントが可能。

■発売日:9月17日■定価:オープン■保証期間:1年  
■連続再生時間:約26時間(ANCオン)約32時間(ANCオフ)  
■重量:約312g■通信方式:Bluetooth®5.0■対応コーデック:SBC  
■ドライバーサイズ:40mm■フル充電時間:約2時間  
■ワイヤレスレンジ:約10m■再生周波数帯域:20~20,000hz■インピーダンス:32Ω  
■付属品:3.5mmステレオミニケーブル(約1.2m)、USBType-C充電ケーブル(約1m)、ヘッドホンポーチ

**ABOUT HouseofMarley**  
HouseofMarley(ハウス・オブ・マーリー)はボブ・マーリーの普遍的な愛や音楽、そして自然や生  
命に対するリスペクトをマーリーファミリーが具象化し、素材と環境に配慮した製品を作ることを実  
現させるために誕生しました。

  *   *   *   *   *   *   *   *   *   *
# Fenwick & West 2012 Pro Bono Annual Report

Our pro bono services have always been integral to the work we do at Fenwick. Our pro bono efforts focus on partnering with like-minded organizations that share our commitment to giving back to the community.
# National Biological Lands Warning for Improper Nonconformance Procedures, Complaint Handling

The FDA warned National Biological Corp. for failure to thoroughly investigate complaints and improper handling of out-of-spec products.

Following an inspection of the company’s Beachwood, Ohio, facility, the agency issued a warning letter noting the company did not validate numerous pieces of equipment used to manufacture its phototherapy devices. The facility failed to validate its crimping machines, including the machine used to produce the devices.

Moreover, according to investigators, the facility had not validated the gluing/curing process it used to manufacture the devices. 

The agency also took issue with the company’s procedures for nonconforming materials. The procedures for such materials did not require evaluations, including determining the need for an evaluation, for all nonconformances, as required by 21 CFR 820.90.

The inspection further found that 500 nonconformances listed as scrap, return to vendor or “use as is” were not evaluated to determine if an investigation was needed, and 14 nonconformances in the facility log were not assigned an initial or final disposition. 

The agency also took the company to task for its handling of complaints. Company procedures for complaints did not address whether an investigation was needed, and complaints were assigned a failure code rather than being evaluated and investigated. Furthermore, the facility’s purchasing and vendor requirements did not list consultants and contractors or off-the-shelf components it uses.

The FDA also hit National Biological for violating risk analysis requirements. The company failed to incorporate several potential hazards from postmarket data into its risk analysis documents, such as complaints indicating potential risks from sharp edges and incorrect timer readings. 

Investigators found the company did not properly calibrate the heat gun used for solder sleeve assembly for its phototherapy device, and the records listed no calibrations by personnel.

Lastly, the company maintained incomplete device history records that failed to properly document rework and reevaluation activities. Three of the six nonconformance reports documenting rework could not be tied to a device history record.
## Tuffclassified

  


**Location:**  
Ahmedabad, Gujarat - India  
  
**Published:**  
2012-03-14 11:17:08  
  
**Contact Info: **  
Kausar  


  


**Description:**

Dharani Academy, the No.1 SAP ABAP training institute located in Vijayawada, INDIA is providing online training on SAP ABAP Module. The institute have excellent and real time SAP ABAP faculties. Training duration would be 50 to 60 hours of training with real time concepts We are charging a very affordable and economical price for teaching SAP ABAP Module We have a customized curriculum and there is a forthcoming batches every week on SAP ABAP Module. We also provide online training on other SAP Modules such as SAP FICO, SD, MM, HR, BASIS etc. Other online training courses include Cognos, SAS 9.2, Informatica, Data Warehousing, Sharepoint etc. To know more details about the course content, course duration, fees, batch timings or any other essential information, Please do contact us at the earliest or drop an email to kausar.dharaniacademy@gmail.com Regards Kausar Business Development Executive Dharani Academy Vijayawada, AndhraPradesh, INDIA
|  |   
---  
**Aside from Doctor Who, pick another favourite British sci-fi series:**  
---  
  
Pick just one? Impossible...way too many wonderful shows...can't be   
done...head will explode...no silcone heaven???   
  
Ok, picked one but not happy to have to choose   


What about The Omega Factor?  
  
Taras

Hitchhikers' Guide to the Galaxy

"If you have to take me apart to get me there, then I don't want to go."  
  
I like Red Dwarf a good deal, but my all-time fav has to be HHGG. More than Doctor Who? I dunno, I kind of think of them as filling different niches. I have, I _think_ seen, heard, or read HHGG in all forms except live performances. So far, even including the new movie that came out, and acknowledging that HHGG's original form was a radio series, my favorite form of HHGG has got to be the books. Possib. CDs of the audio books read by the author. Come to think of that, I'm going to take those with me for the four hour drive I have ahead of me. Good times.   


Blake's 7 is my pick. The show really grows on you. The Tripods get an honorable mention. It slips to #2 because the BBC couldn't see fit to fininsh the series with the final book. Typical short sighted Beeb.  
Blake's 7 changes from season to season. That keeps it fresh.
# 

ON THIS DAY: Rodgers' first Swans victory 

## This week's #ThrowbackThursday recalls Brendan Rodgers' first victory as Swansea City boss.

Seven years ago today, Rodgers prepared his side for a League Cup tie against Barnet, having tasted defeat in his opening Championship match at Hull City.

The season would end in glory for Rodgers and the Swans, with promotion being sealed via a memorable play-off final victory over Reading at Wembley.

#### Swansea City 3 Barnet 0

**League Cup first round**

_Tuesday, August 10, 2010_

Brendan Rodgers tasted his first victory as Swansea City boss after his side cruised past Barnet in the League Cup.

The Swans had spurned an opportunity to take the lead when Shefki Kuqi failed to score from the penalty spot, but Dutchman Cedric van der Gun did make the breakthrough when he headed home Albert Serran’s cross before the half-hour mark.

It wasn’t until the 72nd minute until the Swans doubled their lead as sub Darren Pratley capped off a fine solo move with a neat finish.

Kuqi then made up for his earlier miss when he added a third late on to cap off a successful night for Rodgers and co.

**Swans:** Dorus de Vries, Alan Tate, Garry Monk (capt), Albert Serran, Joe Walsh, Scott Donnelly (Darren Pratley, 63), Andrea Orlandi (Mark Gower, 62), Cedric van der Gun, Kerry Morgan (Nathan Dyer, 74), Shefki Kuqi.

**Subs not used:** Jordi Lopez, Stephen Dobbie, Casey Thomas, Jamie Grimes.

**Attendance:** 6,644.
# Konfusion - Ketama

Ref: 50112UN104

10'35 € VAT not included

12'55 $ 

**Description:**

Flamenco is a very rich and very demanding art, and it is almost impossible to capture its vital flavor without years of training and experience. Ketama, fortunately, has what it takes to deliver excellent New Flamenco. Released in June, 1998, Konfusion has a nice blend of smooth Pop-Jazz-Flamenco sound that promises to please new listeners. Also, the lyrical content of 'Konfusion', is far more thoughtful, interesting, and, even, intellectual than anything found in some of Ketama's earlier 'party' albums. 'De Aki a Ketama' is an absolutely indispensible album and 'Konfusion', while more introspective, will not disappoint any of those who have come to expect the highest caliber of music from this Madrid-based band.   


Flamenco is a very rich and very demanding art, and it is almost impossible to capture its vital flavor without years of training and experience. Ketama, fortunately, has what it takes to deliver excellent New Flamenco. Released in June, 1998, Konfusion has a nice blend of smooth Pop-Jazz-Flamenco sound that promises to please new listeners. Also, the lyrical content of 'Konfusion', is far more thoughtful, interesting, and, even, intellectual than anything found in some of Ketama's earlier 'party' albums. 'De Aki a Ketama' is an absolutely indispensible album and 'Konfusion', while more introspective, will not disappoint any of those who have come to expect the highest caliber of music from this Madrid-based band.   


Songs

Disco 1

1\. Konfusión 

2\. Estatua de sal

3\. Huella de una diosa

4\. Pokito a poko 

5\. Karta kanción 

6\. Para vivir 

7\. Espíritu kañí 

8\. Machukita 

9\. Labios de koral 

10\. El oasis de los dioses 

11\. Suave 

12\. Pasará 

13\. Mi manantial 

14\. Kautivo de la noche 

15\. Ya se marchó 

Artists

Ketama

Juan Carmona

Jose Miguel Carmona

Antonio Carmona

Palos

Flamenco-Pop
# Communication Media - Free Google Slides theme and PowerPoint template

ID: 04028

  * 3 Slides 
  * 4:3 
  * 800x600 
  * 72 DPI 



###  Standard PoweredTemplate License 

Free for personal and commercial use with attribution required.

Created 

November 7, 2008


Download Type 

ZIP 

File Type 

PPT, PPTX 

Slides 

3 Slides 

Light & Dark Version 

No 

Data-Driven 

No 

Ratio 

4:3 

Editable Shapes 

Yes 

Dimensions 

800x600 

DPI 

72 DPI 

Font Included 

No 

Images Included 

Yes 

  * 20 Slides 
  * 4:3 
  * 800x600 
  * 72 DPI 



Created 

November 7, 2008


Download Type 

ZIP 

File Type 

PPT, PPTX 

Slides 

20 Slides 

Light & Dark Version 

No 

Data-Driven 

No 

Ratio 

4:3 

Editable Shapes 

Yes 

Dimensions 

800x600 

DPI 

72 DPI 

Font Included 

No 

Images Included 

Yes 

File| Resolution| Size| Information  
---|---|---|---  
PowerPoint|  \- | 20 Slides  
Word|  \- | 3 Pages  
Brochure|  \- |  The photos are not included  The fonts are not included   
Business Card|  \- |  The photos are not included  The fonts are not included   
Letterhead|  \- |  The photos are not included  The fonts are not included   
Postcard|  \- |  The photos are not included  The fonts are not included   
Newsletter|  \- |  The photos are not included  The fonts are not included   
Flyer|  \- |  The photos are not included  The fonts are not included   
Poster|  \- |  The photos are not included  The fonts are not included   
Ad|  \- |  The photos are not included  The fonts are not included   
  
This presentation template 8840 is complete compatible with Google Slides. Just download PPTX and open the theme in Google Slides. This PowerPoint template will be a great choice for presentations on communication media, communication technology, information sphere, news, TV channels, television, etc.
The Denpa Men 2: Beyond The Waves

**Genres** : RPG

**US release date** : May 30th, 2013 | **EU release date** : May 30th, 2013

**Prices** : $11.99 (US) | £8.99 (UK) | €9.99 (EUR) 

# The Denpa Men 2: Beyond The Waves

At any and all times, mysterious little creatures float around. They're called "Denpa" Men. You can't see them normally, but you can find them and catch them with your Nintendo 3DS.

This is a role-playing game in which you collect Denpa Men to form a party, and use this party to explore dungeons. Each radio wave territory has its own completely unique Denpa Men, and no two of them are ever the same!

Their faces, bodies, and personalities are all different, and some of them even have special skills and strong points. There's a practically infinite number of variations! Sometimes, you'll even find Denpa Men who are exceptionally strong.

Try searching in lots of different places to form your own team of these wonderful tiny critters, and take them on an adventure to rescue a certain special someone from the clutches of the King of Evil!
# Half Board Hotels In Dubai

We have many fantastic deals on cheap hotels in Dubai. Whether it's self catering, half board, bed and breakfast or all inclusive, you'll be sure to find the Dubai accommodation you're after with our extensive hotel database. We have many quality hotels in Dubai to choose from, so use the links below to help you find information on the one that suits you.
# 

三大社快评：西班牙结束44年等待 战胜强大德国

北京时间6月30日凌晨，2008年欧洲杯决赛在维也纳上演。凭借托雷斯在上半场的一粒宝贵进球，西班牙队1-0战胜德国队，最终捧起德劳内杯。而他们上一次获此殊荣，还要追溯到1964年。赛后，欧美几大媒体均对本场比赛给出了独到的点评。  
  
法新社：西班牙结束44年的等待 在2008年欧洲杯上击败德国  
  
在2008年欧洲杯决赛的战场上，西班牙队1-0战胜了德国队，结束了他们长达44年的对冠军的等待。  
  
费尔南多-托雷斯在上半场攻入了唯一进球，帮助大赛中的“后进生”西班牙成功夺魁，这一幕将被永远的载入历史。  
  
自从1964年本土欧洲杯夺冠以来，西班牙队终于又一次夺的了这一荣耀。而他们上一次进入决赛，还要追溯到1984年。  
  
路透社：属于欧洲的托雷斯 用1粒进球完成西班牙的努力  
  
西班牙终于结束了他们长达44年的等待，托雷斯在上半场精彩的1球，帮助西班牙队在一场节奏紧凑的比赛中1-0战胜德国队，取得了欧洲杯决赛的胜利。  
  
西班牙队最后一次出现在欧洲杯的决赛战场上还要追溯到1984年，而自从1964年在本土捧杯后，他们始终在孜孜不倦的追求着属于自己的第二座奖杯。而他们做到了，西班牙的队员们用干脆的传递、完美的技术和防守时严密的纪律性成功的限制住了德国的发挥，并最终捧起了德劳内杯。  
  
托雷斯在比赛第33分钟的进球完美的诠释了一切，包括速度，决心，临门一脚的技术，以及整个团队之间的精彩配合。  
  
德国队向以往一样展现出永不放弃的决心，但他们缺乏有效的组织和传递，现在他们必须等待下一个机会，来第四次捧起欧洲杯了。  
  
美联社：44年后西班牙再夺冠军  
  
在维也纳举行的2008年欧洲杯决赛上，西班牙队1-0战胜德国队，44年后终于又一次赢得了这一荣誉。  
  
托雷斯在33分钟取得进球，难能可贵的是在面对这样一个强大的对手时，西班牙人从没有丝毫让步。自从1964年在本土欧洲杯上夺冠后，时隔44年他们终于又一次达到了冠军的高度。  
  
德国队进入大赛决赛似乎已经成为了一种习惯，而在战胜了这样一个强大的对手后，西班牙队终于可以摆脱他们大赛战绩不佳的骂名。而拥有这样一批才华横溢的球员，使得他们在40多年后终于再次满足了人民的期望。
| Georgian Oval Pattern Double Pocket Privacy (Lock) Style Door Set (Polished Chrome Finish)  
  
---  
|    
| |   
---|---  
  
Features
* 4 1/4 Inch Georgian Pattern Privacy (Lock) Pocket Double Door Set
* Shown in a Polished Chrome Finish
* Measures Measures 1 2/5 Wide by 4 Inch Tall 
* Projection of 1/4 Inch (Approximate) 
* Requires Door Thickness of 1 3/4 Inch
* Flush Pulls May Be Routed for Flush Finish 
* Lock Box Measures 2 1/8 Inch by 5 1/8 Inch (Approximate)
* Set Includes: Four Flush Pulls, Two Skeleton Keys, Mortise Latch and Mounting Hardware
* Finishes Available: Polished Chrome (shown), Polished Brass, Antique Brass, Oil Rubbed Bronze
* Other Designer Finishes Available Upon Request
| Details  
---  
Usually Ships In| 1 to 2 Business Days  
Hardware Included| Yes  
Sold As| Set  
Architectural Style| Georgian  
Warranty| 5 Year Limited Warranty  
Manufacturer| Copper Mountain Hardware  
Item Code: | PIDGOUS26  
**$319.99**  
  
  


Description:   


Georgian Oval Pattern Double Pocket Privacy (Lock) Style Door Set (Polished Chrome) - this set is a designed for a locking pocket door (such as a closet door). The flush pulls are installed on either side of the door and the mortise latch/edge pull pull is installed into the side of the door to pull the doors shut easily and can lock into the each other. Locking systems require doors at least 1 3/4 inch thick. The backset on this style of pocket door hardware is 2 1/2 inch. Dummy and passage style pocket door hardware is also available. Works with a standard skeleton key and comes complete with an ornate set of skeleton keys. Available in Polished Chrome (shown), Polished Brass, Antique Brass, and Oil Rubbed Bronze. Solid Brass construction for decades of service. Made to be routed into the door - and comes complete with the mounting hardware. Note: The passage and privacy pocket door sets do not come with installation instructions. These sets need to be routed into the door by a professional. The pieces of the set are used as the template for routing the door.  
  
---  
  


  


Tips & Tricks:   


Pocket doors are becoming more popular in the United States as a space saving option, with the door sliding into the wall rather than into the room. This set is designed for a double door however single door locking style sets are available.
# Safe sex workshop informs LGBT teens

Teens stay at the library on April 27 after the Safe Sex Workshop to discuss what they learned.

Approximately 20 million new cases of STDs are found in the United States every year. Around half of these are found in young people between the ages of 15 and 24.

On Wednesday, April 27, the Belmont Library and the San Mateo County Pride Center hosted a Safe Sex Workshop for LGBT teens, which was taught by Planned Parenthood.

During the session, teens were informed about possible safety measures they could take, as well as what resources are available to them. 

“This [workshop] is different from the Teen Talk at school because the needs in class are not always met,” said Caitlin Gallardo-Sebti, a health educator at Planned Parenthood. “This is beneficial to high school students because it provides a comfortable environment to ask questions.” 

This workshop was designed to inform specifically LGBT teens about safer sex and as provide a safe environment to ask questions.

“I liked how they supplied everything and answered all the question we had,” said Cameron Garcia Brown, a junior and one of the teens that attended the workshop.

“Even though we have Teen Talk during our freshman year, people tend to forget the important things, and vaguely remember some of the less helpful topics,” said Aspen Woodward, a senior who attended the workshop.

According to Shea Rouland, a senior who attended the session, LGBT teens don’t get enough representation and are often treated as “others,” which is why an LGBT targeted workshop was beneficial to them.

“There is a lack of education for LGBT needs [in school sex-ed classes],” Woodward said. “If some things are mentioned, they don’t always get into it or apply it.”

There were additional aspects of the workshop that made it uniquely helpful.

“This class wasn’t super serious like a classroom environment at school,” Rouland said. “This felt like a more positive environment to ask questions.”

The workshop made its debut this year, and all the participants agreed to host and attend another one of these. 

“This was the first time we’ve had one of these, but we would like to have more,” said Gallardo-Sebti. “In the future, we could also discuss and cover more topics that we could not cover this time.”
**Create Bootable Disk: Specified partition not found. **  
---  
EasyUEFI V2.4 installed under Windows 8.1 on an ASUS M11AD with Secure Boot disabled.   
  
Shortly after selecting "Create Bootable Disk" from the Tools Menu, "Build WinPE Image" aborts with the following Error Message:  
  
Specified partition not found.(0x0006003601C30000)  
  
Disk1: Windows 8.1 [C: & D:]  
Disk2: CentOS 7  
Disk3: Currently an Empty NTFS Drive [E:] on an eSATA Drive  
  
Although I already have a EasyUEFI 1.9 Boot Disk, I wanted to create a "Newer" EasyUEFI 2.4 Boot Disk!  
  
NOTE: Checking for Updates reports  
  
Unable to access version data.  
  
Please make sure the internet is connected, and try again. 

> EasyUEFI V2.4 installed under Windows 8.1 on an ASUS M11AD with Secure Boot disabled.  
>   
>  Shortly after selecting "Create Bootable Disk" from the Tools Menu, "Build WinPE Image" aborts with the following Error Message:  
>   
>  Specified partition not found.(0x0006003601C30000)

  
After installing the 90 Day Windows 10 Enterprise Demo on the eSATA Drive, I succeeded in creating an EasyUEFI 2.4 Boot Disk!!!  Thanks for reporting this problem and we will resolve it as soon as possible.
# Carbon Emissions

## Remove the smokescreen

Language 

Suites: 

Environmental Justice

Subtitle: 

India's environmental problems should not be ignored for the sake of industrial investment

Type: 

Article

Authors: 

Praful Bidwai

Teaser: 

The Indian Prime Minister's call to "go easy" on environmental regulation for fear of scaring off investors follows the flawed ideology that industrial development is the answer to poverty, when actually India's acute environmental deterioration should be the much greater concern.

Body: 

The disclosure by the Centre for Science and Environment that 11 of the 12 leading brands of honey sold in India contain high levels of harmful antibiotics should make us acknowledge our failure to evolve and enforce environmental and health standards. Similar disclosures were made about pesticides in soft drinks and coliform bacteria in 'safe' bottled water. More distressing is the... 

Tags: 

Carbon Emissions

Climate Change

Environmental Degradation

Pollution

Development

Food & Agriculture

Regions: 

Asia

South Asia

India
# You're about to be redirected

The blog that used to be here is now at http://www.traceysculinaryadventures.com/2009/08/msc-chocolate-salted-caramel-cupcakes.html?showComment=1250401635774.

Do you wish to be redirected?
# 辉瑞携创新抗菌药亮相进博，专家共议抗耐药 “四大堵点” 与政策落地

2024年11月7日，为深入贯彻落实《“健康中国2030”规划纲要》和《遏制微生物耐药国家行动计划（2022-2025年）》，以“三医协同，生命速航”三医协同抗耐药，释放创新大价值主题研讨会于11月7日在第七届进博会辉瑞展台举办。来自医疗机构，医保领域等国内知名专家、学者，以及辉瑞中国高层管理人员代表等出席了此次活动，聚焦抗菌药物价值、国谈抗菌药配备、创新药支持政策落地以及优化耐药菌治疗的支付等话题，促进医疗、医保、医药“三医”联动，以应对日益严峻的微生物耐药挑战，助力“健康中国2030”！

辉瑞中国区医院急症及血液与罕见病事业部总经理李进晖表示,“生物制药创新是高质量发展的关键组成部分。辉瑞对于研发新型抗菌药物有着使命般的执着，以应对细菌、真菌、病毒等多种微生物感染的挑战，并不断提升患者对突破性创新药品的可及性与可负担性，造福患者。此次进博会，我们也带来了首个针对金属β-内酰胺酶（MBLs）的β-内酰胺类/β-内酰胺酶抑制剂组合--注射用氨曲南阿维巴坦钠，有望为国内临床医生提供新的治疗选择。同时，我们也将继续与政府有关单位、医疗机构等合作，助力支持我国政府完善抗菌药物管理体系，促进抗菌药物合理使用，遏制耐药菌感染，更好地保障人民健康。”

**打通“四大堵点”，发挥创新型抗菌药物价值**

抗菌药物耐药问题已成为全球公共卫生领域的重大挑战。在全球范围内，耐药菌每年导致100多万人死亡，每年额外支出高达4120亿美元。

浙江省人民医院俞云松教授指出:“在我国，由于抗菌药物使用不合理的问题还比较突出，导致临床重要耐药菌检出率总体上仍呈上升趋势，而目前在研新药非常有限，已上市的创新型抗菌药物可及性有限的情况下，耐药菌感染及治疗失败的风险越来越高,。据相关研究报道，在国谈品各类品种的配备中，抗感染药物配置率相对较低，仅为20%。究其原因，可能是抗菌药物品种品规数量限制、超品种备案规则执行不一致、抗菌药物分级目录更新不及时和医疗费用的严格管控这‘四大堵点’是导致这一问题的主要原因。”

已有研究表明，创新型抗菌药物的恰当配置和合理使用，可降低现有抗菌药物耐药菌的出现风险。创新型抗菌药物在有效应对耐药菌，减少现有抗菌药物耐药率，降低耐药菌感染患者的病死率等方面发挥着重要作用；同时也是驱动创新药产业良性发展重要举措。有效应对耐药，充分发挥创新型抗菌药物的价值是重要举措之一。

针对如何改善创新型抗菌药物临床可及性的问题，俞云松教授建议，打通上述四个堵点是基础，通过适当放宽创新型抗菌药物品种品规数限制；明确创新型抗菌药物超品种品规备案细则和备案流程；定期更新抗菌药物分级目录，科学管理创新型抗菌药物；适当增加重要耐药菌感染患者的救治医疗费用支出等措施来优化和改善国谈创新型抗菌药物的可及性。

**借全链条东风，创新药支持政策落地跑出“上海速度”**

近年来，我国对创新药发展的重视程度不断提高，继今年3月“创新药”首次被写入政府工作报告之后，7月，国务院审议通过了《全链条支持创新药发展实施方案》，这一系列举措标志着我国创新药发展进入新的历史阶段。

上海在全链条创新药支持政策落地方面走在全国前列，早在2021年就已经出台相关政策，支持创新药研发和应用。上海市老年医学中心常务副院长、党委副书记孙湛教授介绍，近年来，上海通过发布国谈落地相关政策、优化医保结算和考核机制、打造三医协同交流平台等多种方式，积极推进国谈创新药合理使用和高效落地。尤其是在政策协助创新药进院方面，“目录发布后1个月内召开药事会”、“新增国谈药应配尽配”、“目录保持每年更新”、“超品种备案让药等患者”等举措跑出了“上海速度”。

在各项政策的推动下，目前上海三级医院国谈药品配备率处于全国领先水平，同时抗菌药物使用强度逐渐降低，抗菌药物使用强度（AUD）降幅大于全国平均水平。上海市老年医学中心积极响应政策开展了一系列卓有成效的工作。该院常务副院长党委副书记孙湛教授表示：“创新药物应用是全链条支持创新药发展的关键环节之一。我院在积极响应政策同时，下一步将在提升医患接受度、数据驱动推广度、‘双通道’助力可及度和药品使用监测机制建立方面做更多的探索与创新。”

**DRG支付下，如何为****CRO分组****“松绑”？**

从2021年至今，国家相关部门围绕深化医改重点任务、支持创新药发展、集采重点工作、加强医保基金监管、优化药品审评审批、推进药品价格治理等方面，相继出台《关于印发DRG/DIP支付方式改革三年行动计划的通知》等多项政策，以政策合力促进“三医”协同发展。

其中，疾病诊断相关分组（DRG）支付方式是基于临床过程同质、复杂程度相似、资源消耗相近原则进行病例分组，并根据近3年病组历史费用制订的病组支付标准进行支付的一种医保付费方式。北京大学公共卫生学院崔斌博士表示，因感染疾病多样且复杂，涉及不同部位，不同菌种，且不同患者基础疾病、既往病史和耐药发生均存在较大差异，DRG支付下抗感染治疗可能存在住院费用变异大，DRG支付标准难以覆盖真实医疗服务成本的风险和问题。

2023年，北大公共卫生学院开展的《DRG付费方式下感染性疾病费用与支付的研究项目》结果表明，耐药组次均住院费用远高于非耐药组，平均高出145.5%。耐药组中，耐碳青霉烯类细菌（CRO）感染病例占耐药病例总数的23.4%，平均住院日25.4天，次均住院费用79759.8元，显著高于其他耐药菌感染；从住院费用支付来看，耐药组DRG支付标准偏低，仅约覆盖次均费用的40-60%左右，而非耐药组DRG支付标准则可覆盖到次均费用的93-99%。

基于此，崔斌博士建议，要根据国家医保局于7月23日发布的《关于印发按病组和病种分值付费2.0版分组方案并深入推进相关工作的通知》精神，进一步完善DRG支付政策。地方可在充分考量当地耐药菌感染对相关DRG病组住院费用和患者负担影响的基础上，进一步完善本地DRG细分组方案；结合耐药菌感染相关疾病的临床特征和资源消耗特点，合理制订和调整相关DRG病组支付标准；并针对耐药菌感染制订针对性支付措施或纳入特例单议，以确保临床能按需应用创新抗菌药物和技术积极救治耐药感染患者，使患者获益。

华中科技大学同济医学院药品政策与管理研究中心陈昊教授主持了此次研讨会，陈昊教授提出，要以合理用药为终极目标，合理用药的内涵包括使用合理、临床合理、经济合理、支付合理,最终诸多环节协调发展，服务于临床患者。此外，此次研讨会还同步举行了圆桌访谈环节，辉瑞中国区副总裁、市场准入及商务部总经理钱云，辉瑞中国区首席医学事务官曹峻洋博士，围绕新政策助力行业提速话题展开分享，发挥医药企业一份力量，不断为中国生物医药产业的高质量发展做出贡献。