opendatalab/WebMainBench huggingface dataset:
# 2021年全球佳品牌100强榜单 Interbrand全球品牌排行榜

知名市场研究机构Interbrand发布了“2021年全球佳品牌排行榜”。榜单以全球各大企业品牌价值为依据进行排序，其中苹果公司以4082.51亿美元的品牌价值蝉联榜单榜首，亚马逊凭借2492.49亿美元品牌价值位居第二位，微软排在榜单第三位。 **排行** | **品牌名称** | **品牌价值（亿美元）** | **品牌价值变化**  
---|---|---|---  
1 | iPhone | 4082.51 | 26%  
2 | Amazon亚马逊 | 2492.49 | 24%  
3 | Microsoft微软 | 2101.91 | 27%  
4 | Google谷歌 | 1968.11 | 19%  
5 | SAMSUNG三星 | 746.35 | 20%  
6 | Coca-Cola可口可乐 | 574.88 | 1%  
7 | TOYOTA丰田 | 541.07 | 5%  
8 | Mercedes-Benz奔驰 | 508.66 | 3%  
9 | MCDONALD&#039;S麦当劳 | 458.65 | 7%  
10 | Disney迪士尼 | 441.83 | 8%  
11 | 耐克 | 425.38 | 24%  
12 | 宝马 | 416.31 | 5%  
13 | LV | 367.66 | 16%  
14 | 特斯拉 | 362.7 | 184%  
15 | 脸书 | 362.48 | 3%  
16 | 思科 | 362.28 | 6%  
17 | 英特尔 | 357.61 | -3%  
18 | IBM | 332.57 | -5%  
19 | Instagram | 320.07 | 23%  
20 | 思爱普 | 300.9 | 7%  
21 | Adobe | 248.32 | 36%  
22 | 香奈儿 | 221.09 | 4%  
23 | 爱马仕 | 216 | 20%  
24 | 摩根大通 | 214.01 | 6%  
25 | 本田 | 213.15 | -2%  
26 | youtube | 209.05 | 21%  
27 | 宜家家居 | 200.34 | 6%  
28 | 百事可乐 | 194.31 | 4%  
29 | ups | 193.77 | 1%  
30 | 美国运通 | 190.75 | -2%  
31 | GE（通用电气） | 184.2 | 3%  
32 | 埃森哲 | 177.58 | 7%  
33 | 古驰 | 166.56 | 6%  
34 | 安联保险集团 | 151.74 | 17%  
35 | 现代汽车 | 151.68 | 6%  
36 | 美国奈飞 | 150.36 | 19%  
37 | 百威啤酒 | 150.22 | -4%  
38 | salesforce | 147.7 | 37%  
39 | visa | 147.41 | 19%  
40 | 雀巢咖啡 | 144.66 | 4%  
41 | 索尼 | 144.46 | 20%  
42 | PayPal | 143.22 | 36%  
43 | HM | 141.33 | 1%  
44 | 帮宝适 | 139.12 | -8%  
45 | ZABA | 135.03 | -9%  
46 | 奥迪 | 134.74 | 8%  
47 | 大众 | 134.23 | 9%  
48 | 安盛集团 | 134.08 | 10%  
49 | 阿迪达斯 | 133.81 | 11%  
50 | 万事达卡 | 130.65 | 18%  
51 | 星巴克 | 130.1 | 16%  
52 | 福特 | 128.61 | 2%  
53 | 巴黎欧莱雅 | 125.01 | 0%  
54 | 花旗银行 | 125.01 | 5%  
55 | 高盛集团 | 124.91 | 3%  
56 | 易贝网 | 122.85 | 0%  
57 | 飞利浦 | 120.88 | 4%  
58 | 保时捷 | 117.39 | 4%  
59 | 尼桑汽车 | 111.31 | 5%  
60 | 西门子 | 110.47 | 5%  
61 | 吉列 | 106.57 | -8%  
62 | 雀巢公司 | 106.46 | 4%  
63 | 惠普 | 104.81 | 8%  
64 | 汇丰银行 | 103.17 | 2%  
65 | 达能集团 | 98.46 | -5%  
66 | spotify | 97.62 | 16%  
67 | 3M | 97.02 | 3%  
68 | 高露洁 | 96.29 | 3%  
69 | 摩根士丹利 | 93.8 | 6%  
70 | 任天堂 | 91.97 | 26%  
71 | 乐高 | 90.82 | 21%  
72 | 家乐氏 | 86.42 | -9%  
73 | 卡地亚 | 81.61 | 9%  
74 | 西班牙国际银行 | 81 | 8%  
75 | 联邦快递 | 75.48 | 2%  
76 | 法拉利 | 71.6 | 12%  
77 | 迪奥 | 70.24 | 17%  
78 | 科罗娜 | 69.52 | 6%  
79 | 佳能 | 68.97 | -14%  
80 | dhl | 67.47 | 7%  
81 | 杰克丹尼 | 65.37 | 4%  
82 | cat鞋 | 65.03 | 11%  
83 | 领英 | 63.68 | 22%  
84 | 惠普企业 | 63.13 | -5%  
85 | 华为 | 61.96 | -2%  
86 | 起亚 | 60.87 | 4%  
87 | 强生 | 59.37 | 3%  
88 | 松下 | 58.32 | 0%  
89 | 喜力啤酒 | 57.2 | 4%  
90 | 美国迪尔 | 56.16 | 5%  
91 | zoom | 55.36 | 24%  
92 | 蒂芙尼 | 54.84 | 10%  
93 | 肯德基 | 54.28 | 6%  
94 | 普拉达 | 54.16 | 20%  
95 | 轩尼诗 | 52.99 | 3%  
96 | MINI | 52.31 | 5%  
97 | 博柏利 | 51.95 | 8%  
98 | 路虎 | 50.88 | 0%  
99 | 优步 | 47.26 | -4%  
100 | 丝芙兰 | 46.28 | new  
  
**2021世界品牌100强排行榜解读**

2021全球品牌百强排行榜显示，上榜100个品牌总价值达26675.24亿美元，同比上年增加了3410.33亿美元，年增长率达15%；百强入围门槛为46.28亿美元，同比上年提高了1.47亿美元。

从品牌价值规模来看，全球品牌100强名单中有4个品牌价值突破1000亿美元，有4个品牌价值在500-1000亿美元之间，有56个品牌价值在100-500亿美元之间，榜单其余36个品牌价值在40-100亿美元之间。

行业方面，科技是全球品牌价值100强榜单中增长快的行业，平均品牌价值同比变化23%。同时，科技行业也是榜单中有价值的行业，其次是饮料和运动用品行业。
## Shenzhen Vanwin Tracking Co.,Ltd

**认证**

**客户评价**

Vanwin 是非常可靠的供应商。我们已经工作了 3 年多。上次我已经从其他公司帮忙安装了 2 个有线 MDVR 系统，但我必须说它们的质量不如你的系统。

我们合作已经三年了。我们喜欢高清监视器和定制的摄像机系统，它们非常清晰和稳定。

您的视频 People Counter 非常好，准确率超过 98%。自上次以来，我们将订购更多 100 套运行良好。

对样品非常满意，达到了所有的期望！几天后购买更多。

人流量统计系统非常好，我会将您的系统整合到我的国家。很高兴能和你这样亲切的人一起工作。

与您合作 3 年非常愉快。我们已经从您那里订购了 600 多套，它们运行良好，我们是合作伙伴，并且会变得更大。

SD 卡 MDVR 系统非常好。很高兴和你一起工作，中餐非常美味。

很好，很好，3G 视频人流量统计系统运行良好。我将使用公共汽车中的 people Counter 系统进行更多测试。我们有 100 多辆公交车

事实证明，Vanwin 是非常好的供应商。有史以来最好的供应商！

  * 产品
  * ##  3G / 4G Real-Time Monitoring Camera recorder with Bus People Counter GPS Tracking OSD

  * ##  Automatic Bus People Counter All In One Real Time Video GPS Tracking for coaster mini bus

  * ##  3G live video streaming CMS based linux bus mobile digital video recorder MDVR with people counter

  * ##  3G WIFI GPS Binocular camera Real-timly Bus People Counter for city service bus

  * ##  GPRS bus passenger counting system with RS232 / RS485 port , Protocol Supported
# 恒大健康发布盈利预警 因造车研发预亏20亿-im电竞体育

本文摘要：**8月9日，香港上市公司恒大健康公布盈利预警，由于新能源汽车业务研发等涉及费用及利息支出大幅度减少，预计上半年袭港大约20亿亏损，而公司的身体健康管理业务仍保持稳定发展。**  


8月9日，香港上市公司恒大健康公布盈利预警，由于新能源汽车业务研发等涉及费用及利息支出大幅度减少，预计上半年袭港大约20亿亏损，而公司的身体健康管理业务仍保持稳定发展。分析人士认为，新能源汽车归属于资金密集型产业，特别是在在技术研发的巨额投放，造成许多车企在前期都面对着亏损问题。

以行业巨头特斯拉为事例，上市以来已倒数亏损9年，今年上半年净亏损超强11亿美元，其中研发开支高达9.8亿美元。即便如此，特斯拉仍获得资本市场寄予厚望，上市以来股价上涨了13倍，市值一度打破福特和菲亚特等美国老牌车企。自今年初以来，恒大健康已建构了覆盖面积整车研发生产、动力电池、电机电控的全产业链，享有世界最先进设备的新能源汽车技术，巨额的研发投放将更进一步稳固恒大健康的技术优势。

未来，随着新车型相继构建量产上市，新能源汽车业务将推展恒大健康业绩强大快速增长。此外，恒大健康的母公司中国恒大同期公布的业绩预告片表明其上半年业绩较好，这也将为恒大健康扩展新能源汽车布局获取基础。今年前7月，恒大构建销售额3223亿元，全年未来将会构建6000亿元销售。

根据此前恒大发布的造车目标，其规划在3至5年沦为世界规模仅次于、实力最弱的新能源汽车集团。
# ​2022年度中国外文局国际传播能力建设研究协调机制课题  


  


为贯彻落实习近平总书记关于加强和改进我国国际传播能力建设的重要讲话精神，拓展研究领域范畴，广泛汇聚各方力量，“中国外文局对外话语体系研究协调机制”自本年度起更名为“中国外文局国际传播能力建设研究协调机制”。目前，该机制2022年度课题招标工作已结束，中国外文局委托当代中国与世界研究院完成全部评审工作，现将中标结果公示如下，公示期为2022年4月29日至5月6日。  


**一、重点课题（10个）**

**编号**| **课题名称**| **申报者**| **申报单位**  
---|---|---|---  
1| 新时代中国治国理政方略的经验启示和世界意义研究| 陶文昭| 中国人民大学  
2| 新时代中国国际传播成就、经验与实践案例研究| 姜飞| 北京外国语大学  
3| 百年变局下中国共产党国际形象调查研究| 高晓林| 复旦大学  
4| 金砖国家在全球治理中的角色和作用研究| 徐秀军| 中国社会科学院  
5| 现代国际传播秩序的运行机制、变迁动力与中国方案研究| 戴元初| 山东大学  
6| 全球发展倡议的中国贡献和国际传播创新案例研究| 王宏新| 北京师范大学  
7| 中国核心政治话语对外传播效果评估与提升策略研究| 袁岳| 北京零点有数数据科技股份有限公司  
8| 新时代中文与中国文化国际传播风险评估与对策研究| 孟源| 教育部中外语言交流合作中心  
9| 中国哲学社会科学期刊国际影响力研究| 张书卿| 中国新闻出版研究院  
10| 数字文化走出去对文化贸易的影响与案例研究| 秦淑娟| 上海对外经贸大学  
  
**二、一般课题（20个）**

**编号**| **课题名称**| **中标者**| **申报单位**  
---|---|---|---  
1| 新时代中国核心政治话语海外学术传播情况调查研究| 王帆| 复旦大学  
2| 中国双碳目标的国际传播研究| 范士明| 北京大学  
3| 红色文化对外话语创新与国际传播研究| 吴贇| 同济大学  
4| 推动世界文明交流互鉴的议题设置研究| 陈薇| 华中科技大学  
5| 北京冬奥会国家形象建设与国际传播经验案例研究| 孙维佳| 北京第二外国语学院  
6| 新形势下中国对欧话语建构与国际传播经验案例研究| 冯仲平| 中国社会科学院  
7| 全人类共同价值的话语与叙事体系建构研究| 孙亮| 华东师范大学  
8| 游戏电竞、在线影视剧及网络文学、动漫、音乐、短视频（直播）等数字文化走出去观察研究| 洪宇| 浙江大学  
9| 基于境外智库的新时代中国核心政治话语传播现状研究| 邱凌| 山东大学  
10| 国际传播赋能我国海外利益发展与安全的叙事体系研究| 戴永红| 深圳大学  
11| 共同富裕视域下新时代中国经济话语国际传播策略探析| 董煜| 清华大学  
12| 央企对外话语体系建设的新突破新进展研究| 于米| 中国大连高级经理学院  
13| 新时代中国国际传播风险防控机制研究| 周敏| 北京师范大学  
14| 融通中外视域下中国特色核心政治话语对外翻译策略研究| 张颖| 北京第二外国语学院  
15| 中国特色话语对外翻译标准管理与应用研究| 曹馨宇| 中国标准化研究院  
16| 算法时代的国家翻译话语对外传播能力构建研究| 任东升| 中国海洋大学  
17| 新时代中国重要概念英译的国际理解度研究| 魏梅| 天津外国语大学  
18| 移动互联网下“Z 世代”群体国际社交话语体系特点与传播规律研究| 戴鑫| 华中科技大学  
19| 元宇宙对国际传播带来的挑战与机遇及应用前景研究| 李庆林| 广西大学  
20| 多边主义危机、国际体系转型与中国方案研究| 陈东晓| 上海国际问题研究院  
  
联系人：朱文博

联系方式：010-6899 5954

中国外文出版发行事业局

当代中国与世界研究院

2022年4月29日
医养结合，让健康守护“团圆幸福” ——乐百家手机版客户端赴启航老年公寓开展爱心义诊活动

送走了春节的欢愉，又迎来了元宵节的喜庆。2019年2月19日是传统节日中的元宵节，也是和家人团聚的日子。为弘扬中华传统美德，尊老、敬老、爱老、孝老，乐百家手机版客户端医养办、党群工作部、医务部、中医科、康复科等12名医务人员来到启航老年公寓开展爱心义诊活动，与公寓的老人们共度元宵佳节，用健康守护老人们的“团圆幸福”。

康复医学科的护士们，为老人们带来了简单易学的手指操和颈椎操：靳岚护士认真的讲解了手指操、颈椎操的具体功效和动作要领，王笑忆护士长、景珊珊护士耐心的为老人们进行现场示范和引导，老人们认真地跟着学、做、练，医护人员不厌其烦为老人们纠正动作，公寓内洋溢出一片欢声笑语，节日氛围浓厚而又温馨。

随后，中医科刘文洲主任带领李苗苗、王玉龙、潘登医师仔细询问了公寓的30多位老人身体健康状况，认真聆听他们的心声，详细解答了老人们的健康咨询；细心、耐心地帮助他们讲解引发身体不适的原因，化解和消除老人的顾虑和担忧，并引导老人科学用药、合理膳食、适当康复运动,直到老人们放心、满意地露出轻松的笑容。

“善医者先医其心，而后医其身，其次则医其未病”，问诊过程中一位年过七旬的老人激动哭了起来，她抽泣着向刘主任叙述着自己被病痛折磨痛苦经历和年轻时不易的奋斗历程，刘主任耐心的倾听、劝慰并为她做出了专业细致的健康引导，半小时过去了，老太太的脸上终于露出了安心和宽慰的笑容，临走时紧握着刘主任手对他和他的团队表示了深深地感谢。

与此同时，义诊现场的另一边热闹非凡，医护人员俯身为老人量血压、测血糖。老人们兴致很高，认真的排着队，测完血糖就接着去量血压，随后医生们逐一对他们进行了健康引导。

这次义诊,让公寓的老人们感受到了乐百家手机版客户端亲人般的关怀和温暖。活动的开展不仅调动了医护人员做好医养结合工作的热情和信心，也进一步了解了老年人的实际需求，以便更好地帮助和关爱老人，为打造老人们的幸福晚年尽到医务人员的社会责任。
# Electronic Code of Federal Regulations

## OMB Control Numbers Assigned Pursuant to the Paperwork Reduction Act

## §1250.501 OMB control numbers assigned pursuant to the Paperwork Reduction Act.

(a) Purpose. This section collects and displays the control numbers assigned to information collection requirements by the Office of Management and Budget contained in 7 CFR part 1250 pursuant to the Paperwork Reduction Act of 1980, Pub. L. 96-511.

(b) Display.

7 CFR section where identified and described| Current OMB control number  
---|---  
Sec.:  
1250.523| 0581-0098  
1250.528| 0581-0098  
1250.529| 0581-0098  
1250.530| 0581-0098  
1250.535| 0581-0098  
  
(Agricultural Marketing Act of 1946, as amended (7 U.S.C. 1621-1627) and Egg Research and Consumer Information Act, as amended (7 U.S.C. 2701-2718))

[48 FR 56566, Dec. 22, 1983]
# MARYLAND LONGITUDINAL DATA SYSTEM CENTER

  * _Board Minutes_

Ross K. Goldstein, _Executive Director_

550 West Baltimore St., Baltimore, MD 21201  
(410) 706-2085  
e-mail: mlds.center@maryland.gov  
web: https://mldscenter.maryland.gov

### Budget

| 

### Organizational Structure

| 

### Origin & Functions

| 

### Reports  
  
---|---|---|---  
  
  
_550 West Baltimore St., Baltimore, Maryland, July 2003. Photo by Diane F. Evartt._   


## ORGANIZATIONAL STRUCTURE

## MARYLAND LONGITUDINAL DATA SYSTEM CENTER

### GOVERNING BOARD

Vacancy, _Chair (chosen by Governor)_

_Appointed by Governor with Senate advice & consent to 3-year terms:_ Rudy D. Anthony; Hussainatu Tengu Blake; Laurie M. Kendall-Ellis; Arian Lendzondzo; Susan M. Sterett, Ph.D. _Terms expire 2025._

_Representative of local superintendent of schools appointed by Governor with Senate advice & consent:_ Jason Dykstra 

_Ex officio:_ Carey M. Wright, Ed.D., State Superintendent of Schools; Rafael J. Lopez, Secretary of Human Services; Vincent N. Schiraldi, Secretary of Juvenile Services; Portia Y. Wu, Esq., Secretary of Labor; Sanjay K. Rai, Ph.D., Secretary of Higher Education; Jay A. Perman, M.D., Chancellor, University System of Maryland; David K. Wilson, Ed.D., President, Morgan State University; Brad Phillips, Ed.D., Executive Director, Maryland Association of Community Colleges; Matthew Power, President, Maryland Independent College & University Association. 

### EXECUTIVE DIRECTOR

Ross K. Goldstein, _Executive Director_ (410) 706-2085  
e-mail: ross.goldstein@maryland.gov

COUNSEL  
Jeaneen J. Johnson, _Counsel_ (410) 576-6462  
e-mail: jjjohnson@oag.state.md.us

DATA MANAGEMENT  
Molly B. Abend, _Coordinator & State Department of Education Liaison_ (410) 767-0037  
e-mail: mollyb.abend@maryland.gov

REPORTING SERVICES  
Ann T. Kellogg, _Director & Maryland Higher Education Commission Liaison_ (410) 767-0425  
e-mail: ann.kellogg@maryland.gov

RESEARCH  
Angela K. Henneberger, Ph.D., _Director_ (410) 706-6341  
e-mail: angela.henneberger@maryland.gov

SYSTEMS MANAGEMENT  
Tejal Cherry, _Director & Chief Information Officer_ (410) 767-7089  
e-mail: tejal.cherry@maryland.gov

WORKFORCE DATA ANALYSIS  
Roy Enehiroana, _Analyst & Maryland Department of Labor Liaison_ (410) 706-2085  
e-mail: roy.enehiroana@maryland.gov
# Love Is the Killer App: How to Win Business and Influence Friends

Are you wondering what the next killer app will be? Do you want to know how you can maintain and add to your value during these rapidly changing times? Are you wondering how the word love can even be used in the context of business?  
  
Instead of wondering, read this book and find out how to become a lovecat—a nice, smart person who succeeds in business and in life.  
  
How do you become a lovecat? By sharing your intangibles. By that I mean:   
**Your knowledge** : everything that comes from all the books that I’ll encourage you to devour.  
**Your network** : the collection of friends and contacts you now have, which I’ll teach you how to grow and nurture.  
**Your compassion** : that human warmth you already possess—in these pages I’ll convince you that you can show it freely at the office.  
  
What happens when you do all this?  
* You become a rich source of information to all around you.  
* You are seen as a person with valuable insight.  
* You are perceived as generous to a fault, producing surprise and delight.  
* You double your business intelligence in one year.  
* You triple your network of personal relationships in two years.  
* You quadruple the number of colleagues in your life who love you like family.  
  
In short, you become one of those amazing, outstanding people to whom everyone turns, who leads rather than follows, who never runs out of ideas, contacts, or friendship.  
  
Here’s the real scoop: Nice guys don’t finish last. They rule!  
---  
  
#### Review: Love Is the Killer App: How to Win Business and Influence Friends

Great book on why we should not have agendas - share what you know, who you know and show love! Sounds out there but really works - this guy worked for Mark Cuban - great insight!

The "big idea" of the book itself is: be genuine and love, and you will succeed and fulfill in business.  
You may think what's to write about for this seemingly abstract and common sense topic. But this book impressed me: it is fun to read, concise, full of practical examples, instructions, and spirits. It's not trying to put the big idea in you. Instead, it's like a nice chat with a friend and getting warmed up by his hearty stories.  
I love this book also because it promotes reading. Too many think they're too busy to read nowadays, especially with internet and Tivo around. Books are still the bread of knowledge and set up a "my reading place" routine for them!  
After almost 10 years, nothing seems obsolete from this book. Kudos!
##  Bodies of mother and infant found inside a well 

Wednesday, 12 September 2012 11:39  The bodies of a one-and-a-half- year old infant and his 38-year-old mother were found dead inside a well in Vihara Junction at Dambulla this morning.  
  
The Police are yet to ascertain the cause of death and are conducting further investigations into the tragedy.  
DM is this news worthy anymore?? we hear this type of stories every day.   
  
tell us how monks and Mervin saved some Goats and Cows Tragedy Ven. Inamaluwe Sumangala Thero over to you sure what is the evident? There were no goats human lives have no value in sri lanka. there are many who would fight against cow and goats being kileed. but human being ???? Mervyn the doktor threatened to commit suicide and now every mother and child is following him. Oh my god,Innocent child,Iam really getting hurt.  
---
# Kroger makes Naloxone more available

The Kroger Co. Logo (PRNewsFoto/The Kroger Co.)

  


On the heels of an announcement that 68 Scioto County residents were saved by the opioid overdose reversal medicine Naloxone, comes an announcement that the Kroger Company Columbus division, will make Naloxone available without a prescription at its 112 pharmacies in Ohio beginning Wednesday, Feb. 17. By that date, Naloxone will also be available in the 84 pharmacies in Kroger’s Cincinnati/Dayton division, one pharmacy in its Central division and three pharmacies in its Mid-Atlantic division – for a total of 200 Kroger pharmacies across Ohio.

Last week, the national chain, CVS made a similar announcement, prompting reaction from Lisa Roberts RN, of the Portsmouth City Health Department.

“There is a national effort to get Naloxone to be more available to anybody that may need it,” Roberts said. “The reason of course for that is that the entire country is in the midst of this terrible opioid epidemic that was ushered in by pain medication.”

Kroger officials are responding to a definite need in communities around the state.

“Unfortunately, Ohio and Kentucky rank in the top five when it comes to the highest overdose death rate according to the Centers for Disease Control. Kroger wants to help reverse this horrible statistic,” Jeff Talbot, vice president of Merchandising for Kroger, Cincinnati/Dayton division, said. “We want families dealing with addiction to know that they can count on having this drug available in the event that they need it.”

Kroger has been working with University of Cincinnati Assistant Professor of Emergency Medicine Dr. Shawn Ryan in developing a protocol and processes for dispensing Naloxone without a prescription in Ohio.

“Pharmacists must follow regulations and procedures to dispense Naloxone,” Ryan said. “It’s critical that pharmacists be able to educate families and friends of loved ones suffering from addiction on how to handle and administer Naloxone if needed. I highly commend Kroger for taking this step to help with the opiate addiction crisis.”

Ohio Attorney General Mike DeWine, said while many first responders carry Naloxone, having it available on a wider basis will no doubt help save lives.

“By increasing access to the life-saving drug Naloxone, we can help bring more people back from the grips of overdoses,” U.S. Senator Rob Portman said. “This marks an important step in our fight to combat addiction and we all need to continue to work for a bottom-up, comprehensive approach to the heroin epidemic.”

The Kroger Co. Logo (PRNewsFoto/The Kroger Co.)
# Emily Tan

Emily Tan is a freelance writer and photographer based in Jersey City, N.J. She been covering all things women, pop culture, music and tech since 2008. Emily has been published in the Seattle Times, AOL Music, Lemondop, CMJ, Spinner, PopEater. Currently, Emily contributes to a various places in the U.S. and U.K. including The Line of Best Fit, Idolator, Village Voice, Diffuser.fm and TheBoombox.com. contributes to various sites and publications in the U.S. and U.K. including TheBoomBox.com, Diffuser.fm, The Line of Best Fit, The 405 and Village Voice. Emily is usually on the hunt for the perfect cup of coffee, at a gig, or cycling around the city.
# Alliance Regional Seminar

# When

6/15/18 to 6/15/18

# Contact

http://www.agfuture.org

Location: Colle McVoy

Minneapolis, MN

United States

Contact: Jenna Baldwin

# Event Description

We live and work in an industry that is being disrupted by technology daily. It’s important for everyone throughout an organization to be able to better understand how technology can create an opportunity to better serve and connect with customers. Equally as important is marketing such innovations to create meaningful brands in agriculture. The day will include discussion on the impact of meaningful brands, a skill building workshop on emerging technologies and exposure to agencies that connect the two. Participants will discover ways to bring innovation and technology to what they do every day.
# Fountain of Saturn, Rome, Italy

## Description

The fountain is probably located in the Temple of Saturn, an ancient Roman temple to the god Saturn. The ruins stand at the foot of the Capitoline Hill in Rome. The original dedication of the temple is traditionally dated to 497 BC. The temple was completely reconstructed by Munatius Plancus in 42 BC. The present ruins represent the third phase of the Temple of Saturn, which was built after a fire in 360 AD. 

## Attributes

Attribute Name| Values  
---|---  
Creator | 

  * G. Massiot & cie

  
Subject | 

  * Fountains
  * Ruins
  * Architecture

  
Date Created | 

  * 1910-01-01

  
Date Digitized | 

  * 2007-01-01

  
Cultural Context | 

  * 4th century

  
Place of Creation | 

  * Rome, Lazio, Italy
  * +41.89193+12.51133
  * Rome

  
Departments and Units | 

  * University of Notre DameHesburgh LibrariesGeneral

  
Member of | 

  * Architectural Lantern Slides of Italy

  
Temporal Coverage | 

  * before or circa 1910

  
Record Visibility |  Public  
Content License | 

  * Creative Commons BY-NC-ND 4.0

  
  
## Files

Thumbnail | File Name | Description | Size | Type | File Access  
---|---|---|---|---|---  
| Italy-Rome-fountain-Saturn.tif | 312 MB | image/tiff |  Public  
| Italy-Rome-fountain-Saturn.jpg | 4.84 MB | image/jpeg |  Public
Hey guys i am new here, looking forward to meeting loads of you!!

Hello Mary, welcome aboard!

Welcome to the TMF, Mary, and congratulations on making your first post.   
This is a wonderful place. Have fun here.

Greetings & welcome.

Greetings and salutations!

Welcome!

Hello Mary, welcome and congrats for being .. tickly !!
# Richmond pulls away from William & Mary 86-78, OT

Richmond pulls away from William & Mary 86-78, OT 

RICHMOND, Va. (AP) Darien Brothers led five players in double-figures with 20 points to help Richmond pull away from William & Mary 86-78 in overtime Wednesday night in the 198th meeting between the programs.

Derrick Williams added 17, Kendall Anthony 15, Greg Robbins 14, and Cedrick Lindsay 12. Williams also grabbed 11 rebounds for the Spiders (5-2) while Lindsay, who missed the previous two games with a concussion, dished out a team high six assists.

Richmond led 76-72 in overtime before Marcus Thornton hit a 3-pointer to draw the Tribe (4-2) within 76-75 with 2:07 left. But the Spiders outscored William & Mary 8-3 over the final 2 minutes to put the game away.

Richmond outshot William & Mary 50 percent (28 of 56) to 48.3 percent (29 of 60) and made a season-high 90 percent (19 of 21) of its free throws.

Thornton led the Tribe with 22 points.
Viewing profile :: Kay Das  
---  
**Avatar** | **All about Kay Das**  
  
| | Joined:  | **28 Mar 2005**  
---|---  
Total posts:  | **1504**  
[0.05% of total / 0.29 posts per day]   
Find all posts by Kay Das  
From:  | **Los Angeles CA**  
Website:  | **http://www.kaydas.me**  
Occupation:  | **engineer, musician**  
Interests: |  **Lap Steel, Pedal Steel, Any instrument that has at least six strings....**  
**Contact Kay Das**  
| E-mail address:  
---  
Private Message: | ****  
Yahoo Messenger:  
ICQ Number:
# TWEAK/Fn14通过激活NF-κB/STAT3信号通路诱导肝星状细胞分泌促炎症因子

**【摘要】：** 研究背景和目的肝纤维化(Liver fibrosis)以肝脏损伤后细胞外基质(extracellular matrix,ECM)大量沉积为特征,是大多数慢性肝脏损伤的最终结果。肝星状细胞(Hepatic stellate cells,HSCs)是产生ECM的主要细胞,是肝纤维化的发生发展的关键细胞。既往研究表明,减少活化HSCs的数量是使肝纤维化逆转的主要因素。最近研究显示肿瘤坏死因子样弱凋亡因子(Tumor necrosis factor-like weak inducer of apoptosis,TWEAK)及其受体成纤维细胞生长因子诱导因子14(Fibroblast growth factor-inducible 14,Fnl4)在肝纤维化的调节过程中起重要的作用,但是目前关于TWEAK/Fnl4信号通路在HSCs中的作用及机制研究较少。因此,这篇研究我们主要揭示HSCs和TWEAK的关系,并探讨其中可能的机制。方法为了研究TWEAK/Fnl4在HSCs中的作用,我们用TWEAK或者小干扰RNA(Small interfering RNA,siRNA)处理 LX-2 细胞,用酶联免疫吸附测定(Enzyme linked immunosorbent assay,ELISA)和实时荧光定量 PCR(Real-time PCR,RT-PCR)法检测相关的促炎症因子的蛋白和mRNA表达水平;并用免疫印迹法(Western Blotting)或 RT-PCR 检测 Fnl4、核转录因子 kappaB(NuclearfactorkappaB,NF-κB)和信号转导子和转录激活子 3(Signal transducers and activators of transcription 3,STAT3)的表达,用western blot检测了细胞质和细胞核中总的和磷酸化NF-κB、STAT3的表达;然后用CCK-8检测LX-2细胞的存活率及Annexin V-FITC/PI凋亡检测试剂盒检测细胞凋亡率;另外我们还研究了微小RNA-19b(microRNA-19b,miR-19b)在TWEAK/Fn14信号通路中的作用。用TWEAK处理细胞后,用RT-PCR检测miR-19b的表达。用miR-19b模拟物(mimic)和抑制物(inbibitor)上/下调miR-19b的表达后,用western blot和RT-PCR检测Fnl4的表达;在LX-2细胞中共转染miR-19b mimic和构建的包含人Fnl4 3'非编码区(Untranslated region,UTR)结合的野生型和突变型质粒,用萤光素酶活性检测试剂盒检测荧光素酶活性。结果我们的研究发现,在LX-2细胞中Fnl4的上调对TWEAK具有时间及剂量的依赖性。TWEAK通过抑制miR-19b的表达而上调Fnl4的表达。TWEAK上调Fnl4后促进HSCs细胞因子的分泌,包括白细胞介素-8(interleukin-8,IL-8),白细胞介素-6(interleukin-6,IL-6),调节活化正常T细胞表达与分泌的趋化因子(regulated upon activation normal T cell expressed and secreted,RANTES)和单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1),这些促炎症因子的表达与 IκB/NF-κB(p65)和JAK2/STAT3信号通路活化密切相关,并且我们还发现了活化的p65和STAT3信号通路可以相互作用,共同促进炎症因子的分泌。结论总之,我们的研究表明在LX-2细胞中,我们发现miR-19b是Fnl4转录后的负调控因子,TWEAK通过下调miR-19b表达从而上调Fn14表达。TWEAK通过Fn14的表达激活NF-κB和STAT3信号通路,并且激活的p65和STAT3这两个信号通路之间可以相互作用,进而增加促炎性因子的分泌。本研究主要揭示了 TWEAK促进HSCs分泌促炎症因子的机制,这项研究可能为肝纤维化的预防和治疗提供新思路。
# 遥奈步性吧春暖花开

中文名 遥奈歩 （はるなあゆみ / Haruna Ayumi） 生年月日 1985年08月 03日 （現在 28歳）狮子座 身高/三围 T164 / B84 (D罩杯) / W58 / H86 / S 血液型 O型 出身地 東京都 所属事務所 趣味・特技 料理・ダンス 

レッドホットフェティッシュ Vol.16 : 遥奈歩

遥奈歩
# 德川家光有着哪些为政举措？有着怎样的成就

政治

宽永十二年(1635年)德川家光修订的《武家诸法度》中，要求所有大名在江户及藩地均建造居所，在江户参拜将军，居住一年以后，才能回到藩内，藩内居住一年又要回江户。当大名回藩时，其亲属则要留在江户。《宽文令》把参觐交代的规定置于第二条：“大名小名在江户交替勤务，每年四月参觐。最近随从人数甚多，增国郡之费、领民之劳，今后应适当减少人数。但上京之节，应随教令，公役者当按分限行事。”顺序的提前，表明幕府对参觐交代前所未有的重视。这一法令的意义在于，此前自发的“参觐”变成了大名必须履行的强制性义务;规定了大名在本藩与江户各一 年执行政务，在本藩称“在国”，在江户称“在府”，原来单纯的“参觐”将军变成了大名定期到江户执行公务;规定了“交代”的时间为每年4月，将“参觐”制度化;要求参觐之际减少人数，按大名身份行事，所谓“分限”，即与家格相应的规范。《宽文令》颁布后，幕府立即向已经在江户的大名发出指令，令萨摩藩主为首的55位大名继续在江户执行勤务，以加贺藩主为首的26位大名则返回本藩。参觐交代制度本身是为了抑制大名势力，提高幕府的权威。在整个江户时代，这种制度被发挥到极致，对于大名的影响是巨大而深刻的。

宗教

元和十年(1624年)，德川家光便下令与西班牙断交，英国看到失去了商机也退出与日本的贸易，因此锁国体制的进程又向前推进了许多。锁国体制逐渐建立，对于基督教来说绝对是一个坏消息，这意味着基督教在德川幕府看来已经几乎失去了在经济方面可以利用的价值，并且在思想文化方面成为遏制儒教学说这一官学的地位的主要威胁。因此，被严厉地打压成为基督教徒在德川家光时期无法逃脱的命运。在家光继承职位之后的十年间里，镇压天主教的行为愈发激烈，神父自不必说，地位比较高的信徒也几乎绝迹。期间，在宽永七年(1630年)，以发布禁止引入中国耶稣会教士的著作的禁止令为开端，全国性的颁布宗教调查寺请制度，以及以长崎为中心的九州地区的踏绘制度，1634年以来的以5人为一组的连坐制度等被实行开来。另外，为了奖励起诉人而制定的褒奖制度，以及天主教血统5代以内的类族改制等诸多方案被采用，下到全国的各个细枝末节，都实行了严格的监管制度。

外交

宽永十年(1633年)2月，德川家光发布了日本历史上的第一次锁国令。禁止奉书船以外船只渡航，此外，禁止滞留外国5年以上的日本人回国。而后，又在宽永十六年(1639年)禁止了葡萄牙船只的渡航。另外，对于包括荷兰人在内的所有外国人适用生丝进口特权，并且在长崎建筑出岛(荷兰人居住地)监禁荷兰人，作为对荷兰人的恩惠，特别允许了荷兰可以同日本进行贸易。此时，可以说，日本同荷兰的海外贸易已经完全掌握在幕府的统治之下，当初幕府的目的终于得到了达成。因此，从这个意义上讲，锁国是在宽永十六年(1639年)得到完成的。