# Dan Rudolf Littman, M.D., Ph.D.

Helen L. and Martin S. Kimmel Professor of Molecular Immunology; Professor;    
Departments of Pathology (Skirball),  Microbiology (Microbiology ) and Molecular Pathogenesis    
  


## Contact Info

**Address**  
540 First Avenue  
Floor 2 Room 2 Lab-17  
Skirball Institute  
New York, NY 10016

Phone: 212-263-7579   
Fax: 212-263-5711  
Email: Dan.Littman@med.nyu.edu   


### Education

1980 — Washington University, St. Louis, Missouri, Graduate Education   


### Research Summary

Our laboratory investigates 1) the molecular events underlying T-lymphocyte differentiation and activation and 2) how the human immunodeficiency virus (HIV) enters target cells and causes systemic depletion of helper T cells. In both areas, we study the functions of T-cell surface molecules and their interactions with intracellular signal transducing components.

During development, CD4 and CD8 glycoproteins are co-expressed on immature thymocytes (double-positive cells), which are then selected according to their ability to interact productively with host major histocompatibility complex (MHC) molecules expressed on thymic epithelium. Cells with T-cell receptors specific for MHC class I shut off CD4 and commit to becoming cytotoxic cells, while cells with T-cell receptors for MHC class II shut off CD8 and become helper cells. We use gene targeting and transgenic technology in mice to study how the double-positive cells commit to either of the two major T-lymphocyte lineages.

In our studies with immunodeficiency viruses, we seek to understand how the interaction of viral envelope glycoproteins with CD4 and various chemokine receptors on the target cells results in membrane fusion and viral entry. We are also developing mouse model systems to determine how HIV infection causes loss of CD4+ helper T cells. In related studies, the functions of chemokine receptors in development and in inflammatory responses are being investigated. 

### Research Interests

T-lymphocyte Development and Retroviral Pathogenesis 

### Research Keywords

CD4, gene silencing, human immunodeficiency virus (HIV), signal transduction, T cells, chemokine receptors 

All data from NYU Health Sciences Library Faculty Bibliography — -

**Contact:**  
http://hsl.med.nyu.edu/faculty-bibliography-search  


**CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22**  
 _Longman, Randy S; Diehl, Gretchen E; Victorio, Daniel A; Huh, Jun R; Galan, Carolina; Miraldi, Emily R; Swaminath, Arun; Bonneau, Richard; Scherl, Ellen J; Littman, Dan R_  
2014 Jul;:229-234, Journal of experimental medicine  
— id: 1075092, year: 2014, vol: , page: 229, stat: Journal Article, 

**Microbiota: Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity**  
 _Longman, Randy S; Yang, Yi; Diehl, Gretchen E; Kim, Sangwon V; Littman, Dan R_  
2014 Jun;:193-201 E3, Cold Spring Harbor symposia on quantitative biology  
— id: 1065422, year: 2014, vol: , page: 193, stat: Journal Article, 

**Decreased bacterial diversity characterizes an altered gut microbiota in psoriatic arthritis and resembles dysbiosis of inflammatory bowel disease**  
 _Scher, Jose U; Ubeda, Carles; Artacho, Alejandro; Attur, Mukundan; Isaac, Sandrine; Reddy, Soumya M; Marmon, Shoshana; Neimann, Andrea; Brusca, Samuel; Patel, Tejas; Manasson, Julia; Pamer, Eric G; Littman, Dan R; Abramson, Steven B_  
2014 Oct;:179-192, Arthritis & rheumatology  
— id: 1310272, year: 2014, vol: , page: 179, stat: Journal Article, 

**Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity**  
 _van de Pavert, Serge A; Ferreira, Manuela; Domingues, Rita G; Ribeiro, Helder; Molenaar, Rosalie; Moreira-Santos, Lara; Almeida, Francisca F; Ibiza, Sales; Barbosa, Ines; Goverse, Gera; Labao-Almeida, Carlos; Godinho-Silva, Cristina; Konijn, Tanja; Schooneman, Dennis; O'Toole, Tom; Mizee, Mark R; Habani, Yasmin; Haak, Esther; Santori, Fabio R; Littman, Dan R; Schulte-Merker, Stefan; Dzierzak, Elaine; Simas, J Pedro; Mebius, Reina E; Veiga-Fernandes, Henrique_  
2014 Apr;508(7494):123-127, Nature  
— id: 867172, year: 2014, vol: 508, page: 123, stat: Journal Article, 

**Focused specificity of intestinal T17 cells towards commensal bacterial antigens**  
 _Yang, Yi; Torchinsky, Miriam B; Gobert, Michael; Xiong, Huizhong; Xu, Mo; Linehan, Jonathan L; Alonzo, Francis; Ng, Charles; Chen, Alessandra; Lin, Xiyao; Sczesnak, Andrew; Liao, Jia-Jun; Torres, Victor J; Jenkins, Marc K; Lafaille, Juan J; Littman, Dan R_  
2014 Apr;:152-156, Nature  
— id: 963022, year: 2014, vol: , page: 152, stat: Journal Article, 

**Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells**  
 _Diehl, Gretchen E; Longman, Randy S; Zhang, Jing-Xin; Breart, Beatrice; Galan, Carolina; Cuesta, Adolfo; Schwab, Susan R; Littman, Dan R_  
2013 Feb;494(7435):116-120, Nature  
— id: 218002, year: 2013, vol: 494, page: 116, stat: Journal Article, 

**Identification of Potent and Selective Diphenylpropanamide RORgamma Inhibitors**  
 _Huh, Jun R; Englund, Erika E; Wang, Hang; Huang, Ruili; Huang, Pengxiang; Rastinejad, Fraydoon; Inglese, James; Austin, Christopher P; Johnson, Ronald L; Huang, Wenwei; Littman, Dan R_  
2013 Jan;4(1):79-84, ACS medicinal chemistry letters  
— id: 531542, year: 2013, vol: 4, page: 79, stat: Journal Article, 

**GPR15-Mediated Homing Controls Immune Homeostasis in the Large Intestine Mucosa**  
 _Kim, Sangwon V; Xiang, Wenkai V; Kwak, Changsoo; Yang, Yi; Lin, Xiyao W; Ota, Mitsuhiko; Sarpel, Umut; Rifkin, Daniel B; Xu, Ruliang; Littman, Dan R_  
2013 May;:1456-1459, Science  
— id: 357322, year: 2013, vol: , page: 1456, stat: Journal Article, 

**Nonredundant function of soluble LTalpha3 produced by innate lymphoid cells in intestinal homeostasis**  
 _Kruglov, Andrey A; Grivennikov, Sergei I; Kuprash, Dmitry V; Winsauer, Caroline; Prepens, Sandra; Seleznik, Gitta Maria; Eberl, Gerard; Littman, Dan R; Heikenwalder, Mathias; Tumanov, Alexei V; Nedospasov, Sergei A_  
2013 Dec;342(6163):1243-1246, Science  
— id: 700602, year: 2013, vol: 342, page: 1243, stat: Journal Article, 

**Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor**  
 _Parkhurst, Christopher N; Yang, Guang; Ninan, Ipe; Savas, Jeffrey N; Yates, John R 3rd; Lafaille, Juan J; Hempstead, Barbara L; Littman, Dan R; Gan, Wen-Biao_  
2013 Dec;155(7):1596-1609, Cell  
— id: 746582, year: 2013, vol: 155, page: 1596, stat: Journal Article, 

**Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis**  
 _Scher, Jose U; Sczesnak, Andrew; Longman, Randy S; Segata, Nicola; Ubeda, Carles; Bielski, Craig; Rostron, Tim; Cerundolo, Vincenzo; Pamer, Eric G; Abramson, Steven B; Huttenhower, Curtis; Littman, Dan R_  
2013 ;2(0):476-483, eLife  
— id: 614432, year: 2013, vol: 2, page: 476, stat: Journal Article, 

**Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy**  
 _Seay, Kieran; Qi, Xiaohua; Zheng, Jian Hua; Zhang, Cong; Chen, Ken; Dutta, Monica; Deneroff, Kathryn; Ochsenbauer, Christina; Kappes, John C; Littman, Dan R; Goldstein, Harris_  
2013 ;8(5):e63537-e63537 e63537, PLoS one  
— id: 531522, year: 2013, vol: 8, page: e63537, stat: Journal Article, 

**Harnessing CD4(+) T cell responses in HIV vaccine development**  
 _Streeck, Hendrik; D'Souza, M Patricia; Littman, Dan R; Crotty, Shane_  
2013 Feb;19(2):143-149, Nature medicine  
— id: 531532, year: 2013, vol: 19, page: 143, stat: Journal Article, 

**A validated regulatory network for th17 cell specification**  
 _Ciofani, Maria; Madar, Aviv; Galan, Carolina; Sellars, Maclean; Mace, Kieran; Pauli, Florencia; Agarwal, Ashish; Huang, Wendy; Parkurst, Christopher N; Muratet, Michael; Newberry, Kim M; Meadows, Sarah; Greenfield, Alex; Yang, Yi; Jain, Preti; Kirigin, Francis K; Birchmeier, Carmen; Wagner, Erwin F; Murphy, Kenneth M; Myers, Richard M; Bonneau, Richard; Littman, Dan R_  
2012 Oct;151(2):289-303, Cell  
— id: 180088, year: 2012, vol: 151, page: 289, stat: Journal Article, 

**Attenuation of Acute Graft-versus-Host Disease in the Absence of the Transcription Factor RORgammat**  
 _Fulton, Leshara M; Carlson, Michael J; Coghill, James M; Ott, Laura E; West, Michelle L; Panoskaltsis-Mortari, Angela; Littman, Dan R; Blazar, Bruce R; Serody, Jonathan S_  
2012 Aug;189(4):1765-1772, Journal of immunology (1950)  
— id: 177111, year: 2012, vol: 189, page: 1765, stat: Journal Article, 

**The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression**  
 _Gialitakis, Manolis; Sellars, Maclean; Littman, Dan R_  
2012 ;356:165-188, Current topics in microbiology & immunology  
— id: 162023, year: 2012, vol: 356, page: 165, stat: Journal Article, 

**A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes**  
 _Glasmacher, Elke; Agrawal, Smita; Chang, Abraham B; Murphy, Theresa L; Zeng, Wenwen; Vander Lugt, Bryan; Khan, Aly A; Ciofani, Maria; Spooner, Chauncey J; Rutz, Sascha; Hackney, Jason; Nurieva, Roza; Escalante, Carlos R; Ouyang, Wenjun; Littman, Dan R; Murphy, Kenneth M; Singh, Harinder_  
2012 Nov;338(6109):975-980, Science  
— id: 185542, year: 2012, vol: 338, page: 975, stat: Journal Article, 

**The microbiome in infectious disease and inflammation**  
 _Honda, Kenya; Littman, Dan R_  
2012 ;30:759-795, Annual review of immunology  
— id: 169442, year: 2012, vol: 30, page: 759, stat: Journal Article, 

**Interactions between the microbiota and the immune system**  
 _Hooper, Lora V; Littman, Dan R; Macpherson, Andrew J_  
2012 Jun;336(6086):1268-1273, Science  
— id: 169557, year: 2012, vol: 336, page: 1268, stat: Journal Article, 

**Small molecule inhibitors of RORgammat: Targeting Th17 cells and other applications**  
 _Huh, Jun R; Littman, Dan R_  
2012 Sep;42(9):2232-2237, European journal of immunology  
— id: 177166, year: 2012, vol: 42, page: 2232, stat: Journal Article, 

**Interleukin 23 Production by Intestinal CD103(+)CD11b(+) Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense**  
 _Kinnebrew, Melissa A; Buffie, Charlie G; Diehl, Gretchen E; Zenewicz, Lauren A; Leiner, Ingrid; Hohl, Tobias M; Flavell, Richard A; Littman, Dan R; Pamer, Eric G_  
2012 Feb;36(2):276-287, Immunity  
— id: 159315, year: 2012, vol: 36, page: 276, stat: Journal Article, 

**Dynamic MicroRNA Gene Transcription and Processing during T Cell Development**  
 _Kirigin, Francis F; Lindstedt, Kenneth; Sellars, Maclean; Ciofani, Maria; Low, Siao Li; Jones, Lachlan; Bell, Fiona; Pauli, Florencia; Bonneau, Richard; Myers, Richard M; Littman, Dan R; Chong, Mark M W_  
2012 Apr;188(7):3257-3267, Journal of immunology (1950)  
— id: 162835, year: 2012, vol: 188, page: 3257, stat: Journal Article, 

**Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs**  
 _Knuckles, Philip; Vogt, Miriam A; Lugert, Sebastian; Milo, Marta; Chong, Mark M W; Hautbergue, Guillaume M; Wilson, Stuart A; Littman, Dan R; Taylor, Verdon_  
2012 ;15(7):962-969, Nature neuroscience  
— id: 171598, year: 2012, vol: 15, page: 962, stat: Journal Article, 

**A rare intestinal infection with systemic effects**  
 _Longman, Randy S; Moreira, Roger K; Littman, Dan R; Green, Peter H R; Sethi, Amrita_  
2012 Jan;8(1):60-63, Gastroenterology & hepatology  
— id: 158634, year: 2012, vol: 8, page: 60, stat: Journal Article, 

**Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis**  
 _Scher, Jose U; Ubeda, Carles; Equinda, Michele; Khanin, Raya; Buischi, Yvonne; Viale, Agnes; Lipuma, Lauren; Attur, Mukundan; Pillinger, Michael H; Weissmann, Gerald; Littman, Dan R; Pamer, Eric G; Bretz, Walter A; Abramson, Steven B_  
2012 May;:3083-3094, Arthritis & rheumatism  
— id: 178156, year: 2012, vol: , page: 3083, stat: Journal Article, 

**Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin**  
 _Teta, Monica; Choi, Yeon Sook; Okegbe, Tishina; Wong, Gabrielle; Tam, Oliver H; Chong, Mark M W; Seykora, John T; Nagy, Andras; Littman, Dan R; Andl, Thomas; Millar, Sarah E_  
2012 Apr;139(8):1405-1416, Development  
— id: 164268, year: 2012, vol: 139, page: 1405, stat: Journal Article, 

**Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells**  
 _Weiss, Jonathan M; Bilate, Angelina M; Gobert, Michael; Ding, Yi; Curotto de Lafaille, Maria A; Parkhurst, Christopher N; Xiong, Huizhong; Dolpady, Jayashree; Frey, Alan B; Ruocco, Maria Grazia; Yang, Yi; Floess, Stefan; Huehn, Jochen; Oh, Soyoung; Li, Ming O; Niec, Rachel E; Rudensky, Alexander Y; Dustin, Michael L; Littman, Dan R; Lafaille, Juan J_  
2012 Sep;209(10):2291-2299, Journal of experimental medicine  
— id: 178843, year: 2012, vol: 209, page: 2291, stat: Journal Article, 

**Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy**  
 _Xu, Cassie; Shen, Yuelei; Littman, Dan R; Dustin, Michael L; Velazquez, Peter_  
2012 Sep;92(3):413-419, Journal of leukocyte biology  
— id: 178144, year: 2012, vol: 92, page: 413, stat: Journal Article, 

**RUNX Transcription Factor-Mediated Association of Cd4 and Cd8 Enables Coordinate Gene Regulation**  
 _Collins, Amelie; Hewitt, Susannah L; Chaumeil, Julie; Sellars, Maclean; Micsinai, Mariann; Allinne, Jeanne; Parisi, Fabio; Nora, Elphege P; Bolland, Dan J; Corcoran, Anne E; Kluger, Yuval; Bosselut, Remy; Ellmeier, Wilfried; Chong, Mark M W; Littman, Dan R; Skok, Jane A_  
2011 Mar 25;34(3):303-314, Immunity  
— id: 129323, year: 2011, vol: 34, page: 303, stat: Journal Article, 

**CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity**  
 _Cruz-Orengo, Lillian; Holman, David W; Dorsey, Denise; Zhou, Liang; Zhang, Penglie; Wright, Melissa; McCandless, Erin E; Patel, Jigisha R; Luker, Gary D; Littman, Dan R; Russell, John H; Klein, Robyn S_  
2011 Feb 14;208(2):327-339, Journal of experimental medicine  
— id: 134177, year: 2011, vol: 208, page: 327, stat: Journal Article, 

**Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene**  
 _Egawa, Takeshi; Littman, Dan R_  
2011 Sep 6;108(36):14873-14878, Proceedings of the National Academy of Sciences of the United States of America  
— id: 137074, year: 2011, vol: 108, page: 14873, stat: Journal Article, 

**Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases**  
 _Hovhannisyan, Zaruhi; Treatman, Jacquelyn; Littman, Dan R; Mayer, Lloyd_  
2011 Mar;140(3):957-965, Gastroenterology  
— id: 134124, year: 2011, vol: 140, page: 957, stat: Journal Article, 

**Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity**  
 _Huh, Jun R; Leung, Monica W L; Huang, Pengxiang; Ryan, Daniel A; Krout, Michael R; Malapaka, Raghu R V; Chow, Jonathan; Manel, Nicolas; Ciofani, Maria; Kim, Sangwon V; Cuesta, Adolfo; Santori, Fabio R; Lafaille, Juan J; Xu, H Eric; Gin, David Y; Rastinejad, Fraydoon; Littman, Dan R_  
2011 Apr 28;472(7344):486-490, Nature  
— id: 131813, year: 2011, vol: 472, page: 486, stat: Journal Article, 

**Modulation of immune homeostasis by commensal bacteria**  
 _Ivanov, Ivaylo I; Littman, Dan R_  
2011 Feb;14(1):106-114, Current opinion in microbiology  
— id: 134125, year: 2011, vol: 14, page: 106, stat: Journal Article, 

**DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration**  
 _Kaneko, Hiroki; Dridi, Sami; Tarallo, Valeria; Gelfand, Bradley D; Fowler, Benjamin J; Cho, Won Gil; Kleinman, Mark E; Ponicsan, Steven L; Hauswirth, William W; Chiodo, Vince A; Kariko, Katalin; Yoo, Jae Wook; Lee, Dong-ki; Hadziahmetovic, Majda; Song, Ying; Misra, Smita; Chaudhuri, Gautam; Buaas, Frank W; Braun, Robert E; Hinton, David R; Zhang, Qing; Grossniklaus, Hans E; Provis, Jan M; Madigan, Michele C; Milam, Ann H; Justice, Nikki L; Albuquerque, Romulo J C; Blandford, Alexander D; Bogdanovich, Sasha; Hirano, Yoshio; Witta, Jassir; Fuchs, Elaine; Littman, Dan R; Ambati, Balamurali K; Rudin, Charles M; Chong, Mark M W; Provost, Patrick; Kugel, Jennifer F; Goodrich, James A; Dunaief, Joshua L; Baffi, Judit Z; Ambati, Jayakrishna_  
2011 Mar 17;471(7338):325-330, Nature  
— id: 134204, year: 2011, vol: 471, page: 325, stat: Journal Article, 

**Role of the commensal microbiota in normal and pathogenic host immune responses**  
 _Littman, Dan R; Pamer, Eric G_  
2011 Oct 4;10(4):311-323, Cell host & microbe  
— id: 139746, year: 2011, vol: 10, page: 311, stat: Journal Article, 

**Hiding in plain sight: how HIV evades innate immune responses**  
 _Manel, Nicolas; Littman, Dan R_  
2011 Oct;147(2):271-274, Cell  
— id: 531552, year: 2011, vol: 147, page: 271, stat: Journal Article, 

**The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment**  
 _Sczesnak, Andrew; Segata, Nicola; Qin, Xiang; Gevers, Dirk; Petrosino, Joseph F; Huttenhower, Curtis; Littman, Dan R; Ivanov, Ivaylo I_  
2011 Sep 15;10(3):260-272, Cell host & microbe  
— id: 137848, year: 2011, vol: 10, page: 260, stat: Journal Article, 

**Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells**  
 _Sujino, Tomohisa; Kanai, Takanori; Ono, Yuichi; Mikami, Yohei; Hayashi, Atsushi; Doi, Tomomitsu; Matsuoka, Katsuyoshi; Hisamatsu, Tadakazu; Takaishi, Hiromasa; Ogata, Haruhiko; Yoshimura, Akihiko; Littman, Dan R; Hibi, Toshifumi_  
2011 Sep;141(3):1014-1023, Gastroenterology  
— id: 137118, year: 2011, vol: 141, page: 1014, stat: Journal Article, 

**The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy**  
 _Zhdanova, Olga; Srivastava, Shekhar; Di, Lie; Li, Zhai; Tchelebi, Leila; Dworkin, Sara; Johnstone, Duncan B; Zavadil, Jiri; Chong, Mark M; Littman, Dan R; Holzman, Lawrence B; Barisoni, Laura; Skolnik, Edward Y_  
2011 Oct;80(7):719-730, Kidney international  
— id: 137467, year: 2011, vol: 80, page: 719, stat: Journal Article, 

**Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology**  
 _Buonocore, Sofia; Ahern, Philip P; Uhlig, Holm H; Ivanov, Ivaylo I; Littman, Dan R; Maloy, Kevin J; Powrie, Fiona_  
2010 Apr 29;464(7293):1371-1375, Nature  
— id: 137120, year: 2010, vol: 464, page: 1371, stat: Journal Article, 

**Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells**  
 _Chong, Mark M W; Simpson, Natalie; Ciofani, Maria; Chen, Grace; Collins, Amelie; Littman, Dan R_  
2010 Apr 1;24(7):659-669, Genes & development  
— id: 109058, year: 2010, vol: 24, page: 659, stat: Journal Article, 

**Canonical and alternate functions of the microRNA biogenesis machinery**  
 _Chong, Mark M W; Zhang, Guoan; Cheloufi, Sihem; Neubert, Thomas A; Hannon, Gregory J; Littman, Dan R_  
2010 Sep 1;24(17):1951-1960, Genes & development  
— id: 112041, year: 2010, vol: 24, page: 1951, stat: Journal Article, 

**Susceptibility of Human Th17 Cells to Human Immunodeficiency Virus and Their Perturbation during Infection**  
 _El Hed, Aimee; Khaitan, Alka; Kozhaya, Lina; Manel, Nicolas; Daskalakis, Demetre; Borkowsky, William; Valentine, Fred; Littman, Dan R; Unutmaz, Derya_  
2010 Mar 15;201(6):843-854, Journal of infectious diseases  
— id: 107380, year: 2010, vol: 201, page: 843, stat: Journal Article, 

**Segmented filamentous bacteria take the stage**  
 _Ivanov, I I; Littman, D R_  
2010 May;3(3):209-212, Mucosal immunology  
— id: 109204, year: 2010, vol: 3, page: 209, stat: Journal Article, 

**Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis**  
 _Jacob, Bindya; Osato, Motomi; Yamashita, Namiko; Wang, Chelsia Qiuxia; Taniuchi, Ichiro; Littman, Dan R; Asou, Norio; Ito, Yoshiaki_  
2010 Feb 25;115(8):1610-1620, Blood  
— id: 137121, year: 2010, vol: 115, page: 1610, stat: Journal Article, 

**Flexible use of nuclear import pathways by HIV-1**  
 _Lee, KyeongEun; Ambrose, Zandrea; Martin, Thomas D; Oztop, Ilker; Mulky, Alok; Julias, John G; Vandegraaff, Nick; Baumann, Joerg G; Wang, Rui; Yuen, Wendy; Takemura, Taichiro; Shelton, Kenneth; Taniuchi, Ichiro; Li, Yuan; Sodroski, Joseph; Littman, Dan R; Coffin, John M; Hughes, Stephen H; Unutmaz, Derya; Engelman, Alan; KewalRamani, Vineet N_  
2010 Mar 18;7(3):221-233, Cell host & microbe  
— id: 119325, year: 2010, vol: 7, page: 221, stat: Journal Article, 

**Th17 and regulatory T cells in mediating and restraining inflammation**  
 _Littman, Dan R; Rudensky, Alexander Y_  
2010 Mar 19;140(6):845-858, Cell  
— id: 108798, year: 2010, vol: 140, page: 845, stat: Journal Article, 

**A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells**  
 _Manel, Nicolas; Hogstad, Brandon; Wang, Yaming; Levy, David E; Unutmaz, Derya; Littman, Dan R_  
2010 Sep 9;467(7312):214-217, Nature  
— id: 112431, year: 2010, vol: 467, page: 214, stat: Journal Article, 

**CXCR4 acts as a costimulator during thymic beta-selection**  
 _Trampont, Paul C; Tosello-Trampont, Annie-Carole; Shen, Yuelei; Duley, Amanda K; Sutherland, Ann E; Bender, Timothy P; Littman, Dan R; Ravichandran, Kodi S_  
2010 Feb;11(2):162-170, Nature immunology  
— id: 134426, year: 2010, vol: 11, page: 162, stat: Journal Article, 

**Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells**  
 _Wu, Hsin-Jung; Ivanov, Ivaylo I; Darce, Jaime; Hattori, Kimie; Shima, Tatsuichiro; Umesaki, Yoshinori; Littman, Dan R; Benoist, Christophe; Mathis, Diane_  
2010 Jun 25;32(6):815-827, Immunity  
— id: 137119, year: 2010, vol: 32, page: 815, stat: Journal Article, 

**Myd88 is required for an antibody response to retroviral infection**  
 _Browne, Edward P; Littman, Dan R_  
2009 Feb;5(2):e1000298-e1000298, PLoS pathogens  
— id: 95887, year: 2009, vol: 5, page: e1000298, stat: Journal Article, 

**RUNX proteins in transcription factor networks that regulate T-cell lineage choice**  
 _Collins, Amelie; Littman, Dan R; Taniuchi, Ichiro_  
2009 Feb;9(2):106-115, Nature reviews. Immunology  
— id: 95888, year: 2009, vol: 9, page: 106, stat: Journal Article, 

**How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets**  
 _Feuerer, Markus; Shen, Yuelei; Littman, Dan R; Benoist, Christophe; Mathis, Diane_  
2009 Oct 16;31(4):654-664, Immunity  
— id: 133735, year: 2009, vol: 31, page: 654, stat: Journal Article, 

**Induction of intestinal Th17 cells by segmented filamentous bacteria**  
 _Ivanov, Ivaylo I; Atarashi, Koji; Manel, Nicolas; Brodie, Eoin L; Shima, Tatsuichiro; Karaoz, Ulas; Wei, Dongguang; Goldfarb, Katherine C; Santee, Clark A; Lynch, Susan V; Tanoue, Takeshi; Imaoka, Akemi; Itoh, Kikuji; Takeda, Kiyoshi; Umesaki, Yoshinori; Honda, Kenya; Littman, Dan R_  
2009 Oct 30;139(3):485-498, Cell  
— id: 105170, year: 2009, vol: 139, page: 485, stat: Journal Article, 

**Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking**  
 _Kim, Joong Kyu; Klinger, Mark; Benjamin, Jonathan; Xiao, Yuanyuan; Erle, David J; Littman, Dan R; Killeen, Nigel_  
2009 ;4(8):e6580-e6580, PLoS one  
— id: 102577, year: 2009, vol: 4, page: e6580, stat: Journal Article, 

**Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells**  
 _Klunker, Sven; Chong, Mark M W; Mantel, Pierre-Yves; Palomares, Oscar; Bassin, Claudio; Ziegler, Mario; Ruckert, Beate; Meiler, Flurina; Akdis, Mubeccel; Littman, Dan R; Akdis, Cezmi A_  
2009 Nov 23;206(12):2701-2715, Journal of experimental medicine  
— id: 137122, year: 2009, vol: 206, page: 2701, stat: Journal Article, 

**RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F**  
 _Leppkes, Moritz; Becker, Christoph; Ivanov, Ivaylo I; Hirth, Sebastian; Wirtz, Stefan; Neufert, Clemens; Pouly, Sandrine; Murphy, Andrew J; Valenzuela, David M; Yancopoulos, George D; Becher, Burkhard; Littman, Dan R; Neurath, Markus F_  
2009 Jan;136(1):257-267, Gastroenterology  
— id: 95893, year: 2009, vol: 136, page: 257, stat: Journal Article, 

**Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin**  
 _Luci, Carmelo; Reynders, Ana; Ivanov, Ivaylo I; Cognet, Celine; Chiche, Laurent; Chasson, Lionel; Hardwigsen, Jean; Anguiano, Esperanza; Banchereau, Jacques; Chaussabel, Damien; Dalod, Marc; Littman, Dan R; Vivier, Eric; Tomasello, Elena_  
2009 Jan;10(1):75-82, Nature immunology  
— id: 95892, year: 2009, vol: 10, page: 75, stat: Journal Article, 

**Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo**  
 _Michel, Nico; Goffinet, Christine; Ganter, Kerstin; Allespach, Ina; Kewalramani, Vineet N; Saifuddin, Mohammed; Littman, Dan R; Greene, Warner C; Goldsmith, Mark A; Keppler, Oliver T_  
2009 ;6:2-2, Retrovirology  
— id: 95889, year: 2009, vol: 6, page: 2, stat: Journal Article, 

**Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells**  
 _Rudra, Dipayan; Egawa, Takeshi; Chong, Mark M W; Treuting, Piper; Littman, Dan R; Rudensky, Alexander Y_  
2009 Nov;10(11):1170-1177, Nature immunology  
— id: 137123, year: 2009, vol: 10, page: 1170, stat: Journal Article, 

**Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22**  
 _Takatori, Hiroaki; Kanno, Yuka; Watford, Wendy T; Tato, Cristina M; Weiss, Greta; Ivanov, Ivaylo I; Littman, Dan R; O'Shea, John J_  
2009 Jan 16;206(1):35-41, Journal of experimental medicine  
— id: 95890, year: 2009, vol: 206, page: 35, stat: Journal Article, 

**Identification of IL-17-producing FOXP3+ regulatory T cells in humans**  
 _Voo, Kui Shin; Wang, Yui-Hsi; Santori, Fabio R; Boggiano, Cesar; Wang, Yi-Hong; Arima, Kazuhiko; Bover, Laura; Hanabuchi, Shino; Khalili, Jahan; Marinova, Ekaterina; Zheng, Biao; Littman, Dan R; Liu, Yong-Jun_  
2009 Mar 24;106(12):4793-4798, Proceedings of the National Academy of Sciences of the United States of America  
— id: 95886, year: 2009, vol: 106, page: 4793, stat: Journal Article, 

**Plasticity of CD4+ T cell lineage differentiation**  
 _Zhou, Liang; Chong, Mark M W; Littman, Dan R_  
2009 May;30(5):646-655, Immunity  
— id: 99221, year: 2009, vol: 30, page: 646, stat: Journal Article, 

**Transcriptional regulatory networks in Th17 cell differentiation**  
 _Zhou, Liang; Littman, Dan R_  
2009 Apr;21(2):146-152, Current opinion in immunology  
— id: 100594, year: 2009, vol: 21, page: 146, stat: Journal Article, 

**Species-specific restriction of apobec3-mediated hypermutation**  
 _Browne, Edward P; Littman, Dan R_  
2008 Feb;82(3):1305-1313, Journal of virology  
— id: 75770, year: 2008, vol: 82, page: 1305, stat: Journal Article, 

**The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease**  
 _Chong, Mark M W; Rasmussen, Jeffrey P; Rudensky, Alexander Y; Littman, Dan R_  
2008 Sep;205(9):2005-2017, Journal of experimental medicine  
— id: 159207, year: 2008, vol: 205, page: 2005, stat: Journal Article, 

**Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping**  
 _Egawa, Takeshi; Kreslavsky, Taras; Littman, Dan R; von Boehmer, Harald_  
2008 ;3(1):e1512-e1512, PLoS one  
— id: 78849, year: 2008, vol: 3, page: e1512, stat: Journal Article, 

**ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage**  
 _Egawa, Takeshi; Littman, Dan R_  
2008 Oct;9(10):1131-1139, Nature immunology  
— id: 93366, year: 2008, vol: 9, page: 1131, stat: Journal Article, 

**Multiple ITAM-coupled NK cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-{kappa}B and MAPK activation to selectively control cytokine production**  
 _Gross, Olaf; Grupp, Christina; Steinberg, Christian; Zimmermann, Stephanie; Strasser, Dominikus; Hannesschlager, Nicole; Reindl, Wolfgang; Jonsson, Helena; Huo, Hairong; Littman, Dan R; Peschel, Christian; Yokoyama, Wayne M; Krug, Anne; Ruland, Jurgen_  
2008 Sep 15;112(6):2421-2428, Blood  
— id: 78850, year: 2008, vol: 112, page: 2421, stat: Journal Article, 

**Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine**  
 _Ivanov, Ivaylo I; Frutos, Rosa de Llanos; Manel, Nicolas; Yoshinaga, Keiji; Rifkin, Daniel B; Sartor, R Balfour; Finlay, B Brett; Littman, Dan R_  
2008 Oct 16;4(4):337-349, Cell host & microbe  
— id: 93379, year: 2008, vol: 4, page: 337, stat: Journal Article, 

**Regulated movement of CD4 in and out of the immunological synapse**  
 _Kao, Henry; Lin, Joseph; Littman, Dan R; Shaw, Andrey S; Allen, Paul M_  
2008 Dec 15;181(12):8248-8257, Journal of immunology (1950)  
— id: 95891, year: 2008, vol: 181, page: 8248, stat: Journal Article, 

**The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat**  
 _Manel, Nicolas; Unutmaz, Derya; Littman, Dan R_  
2008 Jun;9(6):641-649, Nature immunology  
— id: 78844, year: 2008, vol: 9, page: 641, stat: Journal Article, 

**HIV immunology needs a new direction**  
 _Medzhitov, Ruslan; Littman, Dan_  
2008 Oct 2;455(7213):591-591, Nature  
— id: 137124, year: 2008, vol: 455, page: 591, stat: Journal Article, 

**Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma**  
 _Quezada, Sergio A; Peggs, Karl S; Simpson, Tyler R; Shen, Yuelei; Littman, Dan R; Allison, James P_  
2008 Sep 1;205(9):2125-2138, Journal of experimental medicine  
— id: 95895, year: 2008, vol: 205, page: 2125, stat: Journal Article, 

**Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone**  
 _Scandella, Elke; Bolinger, Beatrice; Lattmann, Evelyn; Miller, Simone; Favre, Stephanie; Littman, Dan R; Finke, Daniela; Luther, Sanjiv A; Junt, Tobias; Ludewig, Burkhard_  
2008 Jun;9(6):667-675, Nature immunology  
— id: 78846, year: 2008, vol: 9, page: 667, stat: Journal Article, 

**NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion**  
 _Tassi, Ilaria; Cella, Marina; Presti, Rachel; Colucci, Angela; Gilfillan, Susan; Littman, Dan R; Colonna, Marco_  
2008 Nov 15;112(10):4109-4116, Blood  
— id: 95894, year: 2008, vol: 112, page: 4109, stat: Journal Article, 

**Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut**  
 _Tsuji, Masayuki; Suzuki, Keiichiro; Kitamura, Hiroshi; Maruya, Mikako; Kinoshita, Kazuo; Ivanov, Ivaylo I; Itoh, Kikuji; Littman, Dan R; Fagarasan, Sidonia_  
2008 Aug;29(2):261-271, Immunity  
— id: 95896, year: 2008, vol: 29, page: 261, stat: Journal Article, 

**Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection**  
 _Valdez, Yanet; Diehl, Gretchen E; Vallance, Bruce A; Grassl, Guntram A; Guttman, Julian A; Brown, Nat F; Rosenberger, Carrie M; Littman, Dan R; Gros, Philippe; Finlay, B Brett_  
2008 Aug;10(8):1646-1661, Cellular microbiology  
— id: 78847, year: 2008, vol: 10, page: 1646, stat: Journal Article, 

**Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells**  
 _Zhang, Jing-xin; Diehl, Gretchen E; Littman, Dan R_  
2008 ;3(4):e2035-e2035, PLoS one  
— id: 78845, year: 2008, vol: 3, page: e2035, stat: Journal Article, 

**TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function**  
 _Zhou, Liang; Lopes, Jared E; Chong, Mark M W; Ivanov, Ivaylo I; Min, Roy; Victora, Gabriel D; Shen, Yuelei; Du, Jianguang; Rubtsov, Yuri P; Rudensky, Alexander Y; Ziegler, Steven F; Littman, Dan R_  
2008 May 8;453(7192):236-240, Nature  
— id: 78848, year: 2008, vol: 453, page: 236, stat: Journal Article, 

**HIV's vagina travelogue**  
 _Boggiano, Cesar; Littman, Dan R_  
2007 Feb;26(2):145-147, Immunity  
— id: 71929, year: 2007, vol: 26, page: 145, stat: Journal Article, 

**Dendritic cell-mediated trans-enhancement of HIV-1 infectivity is independent of DC-SIGN**  
 _Boggiano, Cesar; Manel, Nicolas; Littman, Dan R_  
2007 Mar;81(5):2519-2523, Journal of virology  
— id: 69501, year: 2007, vol: 81, page: 2519, stat: Journal Article, 

**The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells**  
 _Egawa, Takeshi; Tillman, Robert E; Naoe, Yoshinori; Taniuchi, Ichiro; Littman, Dan R_  
2007 Aug 6;204(8):1945-1957, Journal of experimental medicine  
— id: 73912, year: 2007, vol: 204, page: 1945, stat: Journal Article, 

**Transcriptional regulation of Th17 cell differentiation**  
 _Ivanov, Ivaylo I; Zhou, Liang; Littman, Dan R_  
2007 Dec;19(6):409-417, Seminars in immunology  
— id: 78851, year: 2007, vol: 19, page: 409, stat: Journal Article, 

**Immunology. Asymmetry and immune memory**  
 _Littman, Dan R; Singh, Harinder_  
2007 Mar 23;315(5819):1673-1674, Science  
— id: 71351, year: 2007, vol: 315, page: 1673, stat: Journal Article, 

**Asymmetry and immune memory**  
 _Littman, DR; Singh, H_  
2007 ;315(5819):1673-1674, Science  
— id: 644062, year: 2007, vol: 315, page: 1673, stat: Journal Article, 

**Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation**  
 _Misra, Ravi S; Russell, Jennifer Q; Koenig, Andreas; Hinshaw-Makepeace, Jennifer A; Wen, Renren; Wang, Demin; Huo, Hairong; Littman, Dan R; Ferch, Uta; Ruland, Jurgen; Thome, Margot; Budd, Ralph C_  
2007 Jul 6;282(27):19365-19374, Journal of biological chemistry  
— id: 78853, year: 2007, vol: 282, page: 19365, stat: Journal Article, 

**Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult**  
 _Motoda, Lena; Osato, Motomi; Yamashita, Namiko; Jacob, Bindya; Chen, Lynnette Q; Yanagida, Masatoshi; Ida, Hiroshi; Wee, Hee-Jun; Sun, Alfred X; Taniuchi, Ichiro; Littman, Dan; Ito, Yoshiaki_  
2007 Dec;25(12):2976-2986, Stem cells  
— id: 78852, year: 2007, vol: 25, page: 2976, stat: Journal Article, 

**Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer**  
 _Naoe, Yoshinori; Setoguchi, Ruka; Akiyama, Kaori; Muroi, Sawako; Kuroda, Masahiko; Hatam, Farah; Littman, Dan R; Taniuchi, Ichiro_  
2007 Aug 6;204(8):1749-1755, Journal of experimental medicine  
— id: 73914, year: 2007, vol: 204, page: 1749, stat: Journal Article, 

**Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse**  
 _Sims, Tasha N; Soos, Timothy J; Xenias, Harry S; Dubin-Thaler, Benjamin; Hofman, Jake M; Waite, Janelle C; Cameron, Thomas O; Thomas, V Kaye; Varma, Rajat; Wiggins, Chris H; Sheetz, Michael P; Littman, Dan R; Dustin, Michael L_  
2007 May 18;129(4):773-785, Cell  
— id: 73235, year: 2007, vol: 129, page: 773, stat: Journal Article, 

**Opposing Effects of PKC? and WASp on Symmetry Breaking and Relocation of the Immunological Synapse**  
 _Sims, TN; Soos, TJ; Xenias, HS; Dubin-Thaler, B; Hofman, JM; Waite, JC; Cameron, TO; Thomas, VK; Varma, R; Wiggins, CH; Sheetz, MP; Littman, DR; Dustin, ML_  
2007 ;129(4):773-785, Cell  
— id: 643772, year: 2007, vol: 129, page: 773, stat: Journal Article, 

**IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways**  
 _Zhou, Liang; Ivanov, Ivaylo I; Spolski, Rosanne; Min, Roy; Shenderov, Kevin; Egawa, Takeshi; Levy, David E; Leonard, Warren J; Littman, Dan R_  
2007 Sep;8(9):967-974, Nature immunology  
— id: 74681, year: 2007, vol: 8, page: 967, stat: Journal Article, 

**A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development**  
 _Burns, Jennifer M; Summers, Bretton C; Wang, Yu; Melikian, Anita; Berahovich, Rob; Miao, Zhenhua; Penfold, Mark E T; Sunshine, Mary Jean; Littman, Dan R; Kuo, Calvin J; Wei, Kevin; McMaster, Brian E; Wright, Kim; Howard, Maureen C; Schall, Thomas J_  
2006 Sep 4;203(9):2201-2213, Journal of experimental medicine  
— id: 69502, year: 2006, vol: 203, page: 2201, stat: Journal Article, 

**Control of microglial neurotoxicity by the fractalkine receptor**  
 _Cardona, Astrid E; Pioro, Erik P; Sasse, Margaret E; Kostenko, Volodymyr; Cardona, Sandra M; Dijkstra, Ineke M; Huang, Deren; Kidd, Grahame; Dombrowski, Stephen; Dutta, RanJan; Lee, Jar-Chi; Cook, Donald N; Jung, Steffen; Lira, Sergio A; Littman, Dan R; Ransohoff, Richard M_  
2006 Jul;9(7):917-924, Nature neuroscience  
— id: 69503, year: 2006, vol: 9, page: 917, stat: Journal Article, 

**A clonogenic bone marrow progenitor specific for macrophages and dendritic cells**  
 _Fogg, Darin K; Sibon, Claire; Miled, Chaouki; Jung, Steffen; Aucouturier, Pierre; Littman, Dan R; Cumano, Ana; Geissmann, Frederic_  
2006 Jan 6;311(5757):83-87, Science  
— id: 69506, year: 2006, vol: 311, page: 83, stat: Journal Article, 

**A clonogenic bone marrow progenitor specific for macrophages and dendritic cells (vol 311, pg 1908, 2005)**  
_Fogg, DK; Sibon, C; Miled, C; Jung, S; Aucouturier, P; Littman, DR; Cumano, A; Geissmann, F_  
2006 MAR 3 ;311(5765):1242-1242, Science  
— id: 62766, year: 2006, vol: 311, page: 1242, stat: Journal Article, 

**The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system**  
 _Huang, DeRen; Shi, Fu-Dong; Jung, Steffen; Pien, Gary C; Wang, Jintang; Salazar-Mather, Thais P; He, Toby T; Weaver, Jennifer T; Ljunggren, Hans-Gustaf; Biron, Christine A; Littman, Dan R; Ransohoff, Richard M_  
2006 May;20(7):896-905, FASEB journal  
— id: 69504, year: 2006, vol: 20, page: 896, stat: Journal Article, 

**Lymphoid tissue inducer cells in intestinal immunity**  
 _Ivanov, I I; Diehl, G E; Littman, D R_  
2006 ;308:59-82, Current topics in microbiology & immunology  
— id: 68779, year: 2006, vol: 308, page: 59, stat: Journal Article, 

**The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells**  
 _Ivanov, Ivaylo I; McKenzie, Brent S; Zhou, Liang; Tadokoro, Carlos E; Lepelley, Alice; Lafaille, Juan J; Cua, Daniel J; Littman, Dan R_  
2006 Sep 22;126(6):1121-1133, Cell  
— id: 69079, year: 2006, vol: 126, page: 1121, stat: Journal Article, 

**CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney**  
 _Soos, T J; Sims, T N; Barisoni, L; Lin, K; Littman, D R; Dustin, M L; Nelson, P J_  
2006 Aug;70(3):591-596, Kidney international  
— id: 66675, year: 2006, vol: 70, page: 591, stat: Journal Article, 

**CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate**  
 _Sun, Jinglin; Soos, Timothy; Kewalramani, Vineet N; Osiecki, Kristin; Zheng, Jian Hua; Falkin, Laurie; Santambrogio, Laura; Littman, Dan R; Goldstein, Harris_  
2006 Feb;80(4):1850-1862, Journal of virology  
— id: 69505, year: 2006, vol: 80, page: 1850, stat: Journal Article, 

**Virus-host interactions: new insights from the small RNA world**  
 _Browne, Edward P; Li, Junjie; Chong, Mark; Littman, Dan R_  
2005 ;6(11):238-238, Genome biology  
— id: 64454, year: 2005, vol: 6, page: 238, stat: Journal Article, 

**Selection and lineage specification in the thymus: commitment 4-stalled**  
 _Collins, Amelie; Littman, Dan R_  
2005 Jul;23(1):4-5, Immunity  
— id: 57847, year: 2005, vol: 23, page: 4, stat: Journal Article, 

**ATP mediates rapid microglial response to local brain injury in vivo**  
 _Davalos, Dimitrios; Grutzendler, Jaime; Yang, Guang; Kim, Jiyun V; Zuo, Yi; Jung, Steffen; Littman, Dan R; Dustin, Michael L; Gan, Wen-Biao_  
2005 Jun;8(6):752-758, Nature neuroscience  
— id: 56024, year: 2005, vol: 8, page: 752, stat: Journal Article, 

**Response to comment on "Thymic origin of intestinal up T cells revealed by fate mapping of ROR gamma t(+) cells"**  
_Eberl, G; Littman, DR_  
2005 JUN 10 ;308(5728):45-54, Science  
— id: 55929, year: 2005, vol: 308, page: 45, stat: Journal Article, 

**Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors**  
 _Egawa, Takeshi; Eberl, Gerard; Taniuchi, Ichiro; Benlagha, Kamel; Geissmann, Frederic; Hennighausen, Lothar; Bendelac, Albert; Littman, Dan R_  
2005 Jun;22(6):705-716, Immunity  
— id: 69511, year: 2005, vol: 22, page: 705, stat: Journal Article, 

**Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development**  
 _Feik, Nicholas; Bilic, Ivan; Tinhofer, Johanna; Unger, Bernd; Littman, Dan R; Ellmeier, Wilfried_  
2005 Feb 1;174(3):1513-1524, Journal of immunology (1950)  
— id: 69512, year: 2005, vol: 174, page: 1513, stat: Journal Article, 

**Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells**  
 _Grueter, Baerbel; Petter, Michaela; Egawa, Takeshi; Laule-Kilian, Kirsten; Aldrian, Christine J; Wuerch, Andreas; Ludwig, Yvonne; Fukuyama, Hidehiro; Wardemann, Hedda; Waldschuetz, Ralph; Moroy, Tarik; Taniuchi, Ichiro; Steimle, Viktor; Littman, Dan R; Ehlers, Marc_  
2005 Aug 1;175(3):1694-1705, Journal of immunology (1950)  
— id: 69510, year: 2005, vol: 175, page: 1694, stat: Journal Article, 

**CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance**  
 _Niess, Jan Hendrik; Brand, Stephan; Gu, Xiubin; Landsman, Limor; Jung, Steffen; McCormick, Beth A; Vyas, Jatin M; Boes, Marianne; Ploegh, Hidde L; Fox, James G; Littman, Dan R; Reinecker, Hans-Christian_  
2005 Jan 14;307(5707):254-258, Science  
— id: 69513, year: 2005, vol: 307, page: 254, stat: Journal Article, 

**Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis**  
 _Odemis, Veysel; Lamp, Elke; Pezeshki, Gita; Moepps, Barbara; Schilling, Karl; Gierschik, Peter; Littman, Dan R; Engele, Jurgen_  
2005 Dec;30(4):494-505, Molecular & cellular neurosciences  
— id: 69509, year: 2005, vol: 30, page: 494, stat: Journal Article, 

**Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver**  
 _Sato, Tohru; Thorlacius, Henrik; Johnston, Brent; Staton, Tracy L; Xiang, Wenkai; Littman, Dan R; Butcher, Eugene C_  
2005 Jan 1;174(1):277-283, Journal of immunology (1950)  
— id: 69514, year: 2005, vol: 174, page: 277, stat: Journal Article, 

**The SDF-1/CXCR4 pathway and the development of the cerebellar system**  
 _Vilz, Tim O; Moepps, Barbara; Engele, Jurgen; Molly, Sabine; Littman, Dan R; Schilling, Karl_  
2005 Oct;22(8):1831-1839, European journal of neuroscience  
— id: 69508, year: 2005, vol: 22, page: 1831, stat: Journal Article, 

**Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle**  
 _Wang, Xiaoxia; Blagden, Chris; Fan, Jihua; Nowak, Scott J; Taniuchi, Ichiro; Littman, Dan R; Burden, Steven J_  
2005 Jul 15;19(14):1715-1722, Genes & development  
— id: 57720, year: 2005, vol: 19, page: 1715, stat: Journal Article, 

**CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells**  
 _Zaft, Tami; Sapoznikov, Anita; Krauthgamer, Rita; Littman, Dan R; Jung, Steffen_  
2005 Nov 15;175(10):6428-6435, Journal of immunology (1950)  
— id: 69507, year: 2005, vol: 175, page: 6428, stat: Journal Article, 

**Murine T cells potently restrict human immunodeficiency virus infection**  
 _Baumann, Jorg G; Unutmaz, Derya; Miller, Michael D; Breun, Sabine K J; Grill, Stacy M; Mirro, Jane; Littman, Dan R; Rein, Alan; KewalRamani, Vineet N_  
2004 Nov;78(22):12537-12547, Journal of virology  
— id: 69516, year: 2004, vol: 78, page: 12537, stat: Journal Article, 

**PKC{theta} Signals Activation versus Tolerance In Vivo**  
 _Berg-Brown, Nancy N; Gronski, Matthew A; Jones, Russell G; Elford, Alisha R; Deenick, Elissa K; Odermatt, Bernhard; Littman, Dan R; Ohashi, Pamela S_  
2004 Mar 15;199(6):743-752, Journal of experimental medicine  
— id: 42239, year: 2004, vol: 199, page: 743, stat: Journal Article, 

**Role of fractalkine and fractalkine receptor in microglia neurotoxicity**  
 _Cardona, AE; Huang, D; Kidd, G; Sasse, ME; Lira, S; Cook, D; Jung, S; Littman, DR; Ransohoff, RM_  
2004 MAY ;63(5):525-525, Journal of neuropathology & experimental neurology  
— id: 46514, year: 2004, vol: 63, page: 525, stat: Journal Article, 

**Thymic origin of intestinal alphabeta T Cells Revealed by Fate Mapping of RORgammat+ Cells**  
 _Eberl, Gerard; Littman, Dan R_  
2004 Aug 9;305(5681):248-251, Science  
— id: 46159, year: 2004, vol: 305, page: 248, stat: Journal Article, 

**An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells**  
 _Eberl, Gerard; Marmon, Shana; Sunshine, Mary-Jean; Rennert, Paul D; Choi, Yongwon; Littman, Dan R_  
2004 Jan;5(1):64-73, Nature immunology  
— id: 42235, year: 2004, vol: 5, page: 64, stat: Journal Article, 

**Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells**  
 _Fonteneau, Jean-Francois; Larsson, Marie; Beignon, Anne-Sophie; McKenna, Kelli; Dasilva, Ida; Amara, Ali; Liu, Yong-Jun; Lifson, Jeffrey D; Littman, Dan R; Bhardwaj, Nina_  
2004 May;78(10):5223-5232, Journal of virology  
— id: 44440, year: 2004, vol: 78, page: 5223, stat: Journal Article, 

**Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion**  
 _Kawakami, Yuko; Nishimoto, Hajime; Kitaura, Jiro; Maeda-Yamamoto, Mari; Kato, Roberta M; Littman, Dan R; Leitges, Michael; Rawlings, David J; Kawakami, Toshiaki_  
2004 Nov 12;279(46):47720-47725, Journal of biological chemistry  
— id: 69519, year: 2004, vol: 279, page: 47720, stat: Journal Article, 

**PKC-theta knockout mice are protected from fat-induced insulin resistance**  
 _Kim, Jason K; Fillmore, Jonathan J; Sunshine, Mary Jean; Albrecht, Bjoern; Higashimori, Takamasa; Kim, Dong-Wook; Liu, Zhen-Xiang; Soos, Timothy J; Cline, Gary W; O'Brien, William R; Littman, Dan R; Shulman, Gerald I_  
2004 Sep;114(6):823-827, Journal of clinical investigation  
— id: 69517, year: 2004, vol: 114, page: 823, stat: Journal Article, 

**Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)**  
_Li, Yu; Soos, Timothy J; Li, Xinghai; Wu, Jiong; Degennaro, Matthew; Sun, Xiaojian; Littman, Dan R; Birnbaum, Morris J; Polakiewicz, Roberto D_  
2004 Oct 29;279(44):45304-45307, Journal of biological chemistry  
— id: 69518, year: 2004, vol: 279, page: 45304, stat: Journal Article, 

**CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors**  
 _Madakamutil, Loui T; Christen, Urs; Lena, Christopher J; Wang-Zhu, Yiran; Attinger, Antoine; Sundarrajan, Monisha; Ellmeier, Wilfried; von Herrath, Matthias G; Jensen, Peter; Littman, Dan R; Cheroutre, Hilde_  
2004 Apr 23;304(5670):590-593, Science  
— id: 69523, year: 2004, vol: 304, page: 590, stat: Journal Article, 

**Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses**  
 _Marsland, Benjamin J; Soos, Timothy J; Spath, Gerald; Littman, Dan R; Kopf, Manfred_  
2004 Jul 19;200(2):181-189, Journal of experimental medicine  
— id: 69520, year: 2004, vol: 200, page: 181, stat: Journal Article, 

**The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity**  
 _Nie, Yuchun; Waite, Janelle; Brewer, Faraha; Sunshine, Mary-Jean; Littman, Dan R; Zou, Yong-Rui_  
2004 Nov 1;200(9):1145-1156, Journal of experimental medicine  
— id: 69515, year: 2004, vol: 200, page: 1145, stat: Journal Article, 

**The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development**  
 _Taniuchi, Ichiro; Ellmeier, Wilfried; Littman, Dan R_  
2004 ;83:55-89, Advances in immunology  
— id: 69522, year: 2004, vol: 83, page: 55, stat: Journal Article, 

**Epigenetic gene silencing by Runx proteins**  
 _Taniuchi, Ichiro; Littman, Dan R_  
2004 May 24;23(24):4341-4345, Oncogene  
— id: 69521, year: 2004, vol: 23, page: 4341, stat: Journal Article, 

**After Hrs with HIV**  
 _Amara, Ali; Littman, Dan R_  
2003 Aug 4;162(3):371-375, Journal of cell biology  
— id: 39117, year: 2003, vol: 162, page: 371, stat: Journal Article, 

**The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells**  
 _Chalasani, Sreekanth H; Baribaud, Frederic; Coughlan, Christine M; Sunshine, Mary J; Lee, Virginia M Y; Doms, Robert W; Littman, Dan R; Raper, Jonathan A_  
2003 Jun 1;23(11):4601-4612, Journal of neuroscience  
— id: 42236, year: 2003, vol: 23, page: 4601, stat: Journal Article, 

**A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding**  
 _Chalasani, Sreekanth H; Sabelko, Kimberly A; Sunshine, Mary J; Littman, Dan R; Raper, Jonathan A_  
2003 Feb 15;23(4):1360-1371, Journal of neuroscience  
— id: 42237, year: 2003, vol: 23, page: 1360, stat: Journal Article, 

**The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches**  
 _Eberl, Gerard; Littman, Dan R_  
2003 Oct;195(19):81-90, Immunological reviews  
— id: 39077, year: 2003, vol: 195, page: 81, stat: Journal Article, 

**Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation**  
 _Egawa, Takeshi; Albrecht, Bjorn; Favier, Benoit; Sunshine, Mary-Jean; Mirchandani, Kanchan; O'Brien, William; Thome, Margot; Littman, Dan R_  
2003 Jul 15;13(14):1252-1258, Current biology. CB  
— id: 39138, year: 2003, vol: 13, page: 1252, stat: Journal Article, 

**Blood monocytes consist of two principal subsets with distinct migratory properties**  
 _Geissmann, Frederic; Jung, Steffen; Littman, Dan R_  
2003 Jul;19(1):71-82, Immunity  
— id: 39135, year: 2003, vol: 19, page: 71, stat: Journal Article, 

**Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E**  
 _Huo, Yuqing; Schober, Andreas; Forlow, S Bradley; Smith, David F; Hyman, Matthew Craig; Jung, Steffen; Littman, Dan R; Weber, Christian; Ley, Klaus_  
2003 Jan;9(1):61-67, Nature medicine  
— id: 42238, year: 2003, vol: 9, page: 61, stat: Journal Article, 

**The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival**  
 _Molyneaux, Kathleen A; Zinszner, Helene; Kunwar, Prabhat S; Schaible, Kyle; Stebler, Jurg; Sunshine, Mary Jean; O'Brien, William; Raz, Erez; Littman, Dan; Wylie, Chris; Lehmann, Ruth_  
2003 Sep;130(18):4279-4286, Development  
— id: 52649, year: 2003, vol: 130, page: 4279, stat: Journal Article, 

**Protein kinase C-theta;: signaling from the center of the T-cell synapse**  
 _Arendt, Christopher W; Albrecht, Bjorn; Soos, Timothy J; Littman, Dan R_  
2002 Jun;14(3):323-330, Current opinion in immunology  
— id: 32454, year: 2002, vol: 14, page: 323, stat: Journal Article, 

**The chemokine SDF1 regulates migration of dentate granule cells**  
 _Bagri, Anil; Gurney, Theresa; He, Xiaoping; Zou, Yong-Rui; Littman, Dan R; Tessier-Lavigne, Marc; Pleasure, Samuel J_  
2002 Sep;129(18):4249-4260, Development  
— id: 69525, year: 2002, vol: 129, page: 4249, stat: Journal Article, 

**Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes**  
 _Chi, Tian H; Wan, Mimi; Zhao, Keji; Taniuchi, Ichiro; Chen, Lei; Littman, Dan R; Crabtree, Gerald R_  
2002 Jul 11;418(6894):195-199, Nature  
— id: 69526, year: 2002, vol: 418, page: 195, stat: Journal Article, 

**Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression**  
 _Ellmeier, Wilfried; Sunshine, Mary Jean; Maschek, Romana; Littman, Dan R_  
2002 May;16(5):623-634, Immunity  
— id: 69528, year: 2002, vol: 16, page: 623, stat: Journal Article, 

**Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes**  
 _Guo, Jian; Hawwari, Abbas; Li, Hong; Sun, Zuoming; Mahanta, Sanjeev K; Littman, Dan R; Krangel, Michael S; He, You-Wen_  
2002 May;3(5):469-476, Nature immunology  
— id: 69530, year: 2002, vol: 3, page: 469, stat: Journal Article, 

**Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent**  
 _Harmsen, Allen; Kusser, Kimberley; Hartson, Louise; Tighe, Michael; Sunshine, Mary Jean; Sedgwick, Jonathon D; Choi, Yongwon; Littman, Dan R; Randall, Troy D_  
2002 Feb 1;168(3):986-990, Journal of immunology (1950)  
— id: 69532, year: 2002, vol: 168, page: 986, stat: Journal Article, 

**In Vivo Depletion of CD11c(+) Dendritic Cells Abrogates Priming of CD8(+) T Cells by Exogenous Cell-Associated Antigens**  
 _Jung, Steffen; Unutmaz, Derya; Wong, Phillip; Sano, Gen-Ichiro; De los Santos, Kenia; Sparwasser, Tim; Wu, Shengji; Vuthoori, Sri; Ko, Kyung; Zavala, Fidel; Pamer, Eric G; Littman, Dan R; Lang, Richard A_  
2002 Aug;17(2):211-220, Immunity  
— id: 32272, year: 2002, vol: 17, page: 211, stat: Journal Article, 

**Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1**  
 _Keppler, Oliver T; Welte, Frank J; Ngo, Tuan A; Chin, Peggy S; Patton, Kathryn S; Tsou, Chia-Lin; Abbey, Nancy W; Sharkey, Mark E; Grant, Robert M; You, Yun; Scarborough, John D; Ellmeier, Wilfried; Littman, Dan R; Stevenson, Mario; Charo, Israel F; Herndier, Brian G; Speck, Roberto F; Goldsmith, Mark A_  
2002 Mar 18;195(6):719-736, Journal of experimental medicine  
— id: 69531, year: 2002, vol: 195, page: 719, stat: Journal Article, 

**DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection**  
 _Kwon, Douglas S; Gregorio, Glenn; Bitton, Natacha; Hendrickson, Wayne A; Littman, Dan R_  
2002 Jan;16(1):135-144, Immunity  
— id: 39719, year: 2002, vol: 16, page: 135, stat: Journal Article, 

**Epigenetic Regulation in T Cell Development**  
 _Littman, Dan_  
[S.l.] : NIH, 2002,   
— id: 1424, year: 2002, vol: , page: , stat: , 

**Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice**  
 _Ohlrogge, Wiebke; Haag, Friedrich; Lohler, Jurgen; Seman, Michel; Littman, Dan R; Killeen, Nigel; Koch-Nolte, Friedrich_  
2002 Nov;22(21):7535-7542, Molecular & cellular biology  
— id: 69524, year: 2002, vol: 22, page: 7535, stat: Journal Article, 

**Chemokine requirements for B cell entry to lymph nodes and Peyer's patches**  
 _Okada, Takaharu; Ngo, Vu N; Ekland, Eric H; Forster, Reinhold; Lipp, Martin; Littman, Dan R; Cyster, Jason G_  
2002 Jul 1;196(1):65-75, Journal of experimental medicine  
— id: 69527, year: 2002, vol: 196, page: 65, stat: Journal Article, 

**Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development**  
 _Taniuchi, Ichiro; Osato, Motomi; Egawa, Takeshi; Sunshine, Mary Jean; Bae, Suk Chul; Komori, Toshihisa; Ito, Yoshiaki; Littman, Dan R_  
2002 Nov 27;111(5):621-633, Cell  
— id: 39359, year: 2002, vol: 111, page: 621, stat: Journal Article, 

**Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation**  
 _Taniuchi, Ichiro; Sunshine, Mary Jean; Festenstein, Richard; Littman, Dan R_  
2002 Nov;10(5):1083-1096, Molecular cell  
— id: 39365, year: 2002, vol: 10, page: 1083, stat: Journal Article, 

**Nuclear hormone receptors in T lymphocytes**  
 _Winoto, Astar; Littman, Dan R_  
2002 Apr;109 Suppl:S57-S66, Cell  
— id: 69529, year: 2002, vol: 109 Suppl, page: S57, stat: Journal Article, 

**HIV: master of the host cell**  
 _Arendt CW; Littman DR_  
2001 ;2(11):REVIEWS1030-REVIEWS1030, Genome biology  
— id: 26504, year: 2001, vol: 2, page: REVIEWS1030, stat: Journal Article, 

**Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN**  
 _Baribaud, F; Pohlmann, S; Sparwasser, T; Kimata, M T; Choi, Y K; Haggarty, B S; Ahmad, N; Macfarlan, T; Edwards, T G; Leslie, G J; Arnason, J; Reinhart, T A; Kimata, J T; Littman, D R; Hoxie, J A; Doms, R W_  
2001 Nov;75(21):10281-10289, Journal of virology  
— id: 531582, year: 2001, vol: 75, page: 10281, stat: Journal Article, 

**Human GLI-2 is a tat activation response element-independent Tat cofactor**  
 _Browning, C M; Smith, M J; Clark, N M; Lane, B R; Parada, C; Montano, M; KewalRamani, V N; Littman, D R; Essex, M; Roeder, R G; Markovitz, D M_  
2001 Mar;75(5):2314-2323, Journal of virology  
— id: 531602, year: 2001, vol: 75, page: 2314, stat: Journal Article, 

**A coordinated change in chemokine responsiveness guides plasma cell movements**  
 _Hargreaves, D C; Hyman, P L; Lu, T T; Ngo, V N; Bidgol, A; Suzuki, G; Zou, Y R; Littman, D R; Cyster, J G_  
2001 Jul;194(1):45-56, Journal of experimental medicine  
— id: 531592, year: 2001, vol: 194, page: 45, stat: Journal Article, 

**The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium**  
 _Huo, Y; Weber, C; Forlow, S B; Sperandio, M; Thatte, J; Mack, M; Jung, S; Littman, D R; Ley, K_  
2001 Nov;108(9):1307-1314, Journal of clinical investigation  
— id: 531572, year: 2001, vol: 108, page: 1307, stat: Journal Article, 

**Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues**  
 _Palframan, R T; Jung, S; Cheng, G; Weninger, W; Luo, Y; Dorf, M; Littman, D R; Rollins, B J; Zweerink, H; Rot, A; von Andrian, U H_  
2001 Nov;194(9):1361-1373, Journal of experimental medicine  
— id: 531562, year: 2001, vol: 194, page: 1361, stat: Journal Article, 

**Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1**  
 _Pierani, A; Moran-Rivard, L; Sunshine, M J; Littman, D R; Goulding, M; Jessell, T M_  
2001 Feb;29(2):367-384, Neuron  
— id: 104486, year: 2001, vol: 29, page: 367, stat: Journal Article, 

**Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development**  
 _Wolfer, A; Bakker, T; Wilson, A; Nicolas, M; Ioannidis, V; Littman, D R; Lee, P P; Wilson, C B; Held, W; MacDonald, H R; Radtke, F_  
2001 Mar;2(3):235-241, Nature immunology  
— id: 531612, year: 2001, vol: 2, page: 235, stat: Journal Article, 

**Inactivation of Notch I in immature thymocytes does not perturb CD4 or CD8T cell development**  
 _Wolfer, A; Bakker, T; Wilson, A; Nicolas, M; Ioannidis, V; Littman, DR; Wilson, CB; Held, W; MacDonald, HR; Radtke, F_  
2001 MAR ;2(3):235-241, Nature immunology  
— id: 55143, year: 2001, vol: 2, page: 235, stat: Journal Article, 

**Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage**  
 _Zou YR; Sunshine MJ; Taniuchi I; Hatam F; Killeen N; Littman DR_  
2001 Nov;29(3):332-336, Nature genetics  
— id: 26588, year: 2001, vol: 29, page: 332, stat: Journal Article, 

**Severe B cell deficiency in mice lacking the tec kinase family members tec and Btk [In Process Citation]**  
_Ellmeier W; Jung S; Sunshine MJ; Hatam F; Xu Y; Baltimore D; Mano H; Littman DR_  
2000 Dec 4;192(11):1611-1624, Journal of experimental medicine  
— id: 15113, year: 2000, vol: 192, page: 1611, stat: Journal Article, 

**Severe B cell-deficiency in mice lacking the Tec kinase family members Btk and Tec**  
 _Ellmeier, W; Sunshine, M J; Jung, S; Xu, Y; Baltimore, D; Mano, H; Littman, D R_  
2000 Sept 23-26;73(2-3):131-131, Immunology letters  
— id: 15800, year: 2000, vol: 73, page: 131, stat: Journal Article, 

**DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells [see comments]**  
_Geijtenbeek TB; Kwon DS; Torensma R; van Vliet SJ; van Duijnhoven GC; Middel J; Cornelissen IL; Nottet HS; KewalRamani VN; Littman DR; Figdor CG; van Kooyk Y_  
2000 Mar 3;100(5):587-597, Cell  
— id: 8528, year: 2000, vol: 100, page: 587, stat: Journal Article, 

**Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway**  
 _Gu C; Ma YC; Benjamin J; Littman D; Chao MV; Huang XY_  
2000 Jul 7;275(27):20726-20733, Journal of biological chemistry  
— id: 14641, year: 2000, vol: 275, page: 20726, stat: Journal Article, 

**Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion**  
 _Jung S; Aliberti J; Graemmel P; Sunshine MJ; Kreutzberg GW; Sher A; Littman DR_  
2000 Jun;20(11):4106-4114, Molecular & cellular biology  
— id: 11707, year: 2000, vol: 20, page: 4106, stat: Journal Article, 

**PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes**  
 _Sun Z; Arendt CW; Ellmeier W; Schaeffer EM; Sunshine MJ; Gandhi L; Annes J; Petrzilka D; Kupfer A; Schwartzberg PL; Littman DR_  
2000 Mar 23;404(6776):402-407, Nature  
— id: 11778, year: 2000, vol: 404, page: 402, stat: Journal Article, 

**Requirement for RORgamma in thymocyte survival and lymphoid organ development**  
 _Sun Z; Unutmaz D; Zou YR; Sunshine MJ; Pierani A; Brenner-Morton S; Mebius RE; Littman DR_  
2000 Jun 30;288(5475):2369-2373, Science  
— id: 11628, year: 2000, vol: 288, page: 2369, stat: Journal Article, 

**The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern Is conserved between human and mouse [In Process Citation]**  
_Unutmaz D; Xiang W; Sunshine MJ; Campbell J; Butcher E; Littman DR_  
2000 Sep 15;165(6):3284-3292, Journal of immunology (1950)  
— id: 11512, year: 2000, vol: 165, page: 3284, stat: Journal Article, 

**The regulation of CD4 and CD8 coreceptor gene expression during T cell development**  
 _Ellmeier W; Sawada S; Littman DR_  
1999 ;17:523-554, Annual review of immunology  
— id: 6131, year: 1999, vol: 17, page: 523, stat: Journal Article, 

**Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells**  
 _Fowell DJ; Shinkai K; Liao XC; Beebe AM; Coffman RL; Littman DR; Locksley RM_  
1999 Oct;11(4):399-409, Immunity  
— id: 15114, year: 1999, vol: 11, page: 399, stat: Journal Article, 

**Chemokine receptors in lymphoid organ homeostasis**  
 _Jung S; Littman DR_  
1999 Jun;11(3):319-325, Current opinion in immunology  
— id: 6143, year: 1999, vol: 11, page: 319, stat: Journal Article, 

**Coreceptor specificity of temporal variants of simian immunodeficiency virus Mne**  
 _Kimata JT; Gosink JJ; KewalRamani VN; Rudensey LM; Littman DR; Overbaugh J_  
1999 Feb;73(2):1655-1660, Journal of virology  
— id: 57042, year: 1999, vol: 73, page: 1655, stat: Journal Article, 

**Fusion-competent vaccines: broad neutralization of primary isolates of HIV**  
 _LaCasse RA; Follis KE; Trahey M; Scarborough JD; Littman DR; Nunberg JH_  
1999 Jan 15;283(5400):357-362, Science  
— id: 7380, year: 1999, vol: 283, page: 357, stat: Journal Article, 

**Role of the nuclear hormone receptor ROR gamma in transcriptional regulation, thymocyte survival, and lymphoid organogenesis**  
 _Littman DR; Sun Z; Unutmaz D; Sunshine MJ; Petrie HT; Zou YR_  
1999 ;64(3):373-381, Cold Spring Harbor symposia on quantitative biology  
— id: 39445, year: 1999, vol: 64, page: 373, stat: Journal Article, 

**Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage**  
 _Morner A; Bjorndal A; Albert J; Kewalramani VN; Littman DR; Inoue R; Thorstensson R; Fenyo EM; Bjorling E_  
1999 Mar;73(3):2343-2349, Journal of virology  
— id: 57056, year: 1999, vol: 73, page: 2343, stat: Journal Article, 

**Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity**  
 _Schaeffer EM; Debnath J; Yap G; McVicar D; Liao XC; Littman DR; Sher A; Varmus HE; Lenardo MJ; Schwartzberg PL_  
1999 Apr 23;284(5414):638-641, Science  
— id: 15116, year: 1999, vol: 284, page: 638, stat: Journal Article, 

**A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice**  
 _Shelbourne PF; Killeen N; Hevner RF; Johnston HM; Tecott L; Lewandoski M; Ennis M; Ramirez L; Li Z; Iannicola C; Littman DR; Myers RM_  
1999 May;8(5):763-774, Human molecular genetics  
— id: 15117, year: 1999, vol: 8, page: 763, stat: Journal Article, 

**Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes**  
 _Unutmaz D; KewalRamani VN; Marmon S; Littman DR_  
1999 Jun 7;189(11):1735-1746, Journal of experimental medicine  
— id: 6133, year: 1999, vol: 189, page: 1735, stat: Journal Article, 

**Differential requirements for CD4 in TCR-ligand interactions**  
 _Vidal K; Daniel C; Hill M; Littman DR; Allen PM_  
1999 Nov 1;163(9):4811-4818, Journal of immunology (1950)  
— id: 15115, year: 1999, vol: 163, page: 4811, stat: Journal Article, 

**A new classification for HIV-1**  
 _Berger EA; Doms RW; Fenyo EM; Korber BT; Littman DR; Moore JP; Sattentau QJ; Schuitemaker H; Sodroski J; Weiss RA_  
1998 Jan 15;391(6664):240-240, Nature  
— id: 57407, year: 1998, vol: 391, page: 240, stat: Journal Article, 

**Neutralization profiles of primary human immunodeficiency virus type 1 isolates in the context of coreceptor usage**  
 _Cecilia D; KewalRamani VN; O'Leary J; Volsky B; Nyambi P; Burda S; Xu S; Littman DR; Zolla-Pazner S_  
1998 Sep;72(9):6988-6996, Journal of virology  
— id: 7527, year: 1998, vol: 72, page: 6988, stat: Journal Article, 

**Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells**  
 _Ellmeier W; Sunshine MJ; Losos K; Littman DR_  
1998 Oct;9(4):485-496, Immunity  
— id: 57144, year: 1998, vol: 9, page: 485, stat: Journal Article, 

**The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein**  
 _Garber ME; Wei P; KewalRamani VN; Mayall TP; Herrmann CH; Rice AP; Littman DR; Jones KA_  
1998 Nov 15;12(22):3512-3527, Genes & development  
— id: 7572, year: 1998, vol: 12, page: 3512, stat: Journal Article, 

**The amino terminus of human CCR5 is required for its function as a receptor for diverse human and simian immunodeficiency virus envelope glycoproteins**  
 _Hill CM; Kwon D; Jones M; Davis CB; Marmon S; Daugherty BL; DeMartino JA; Springer MS; Unutmaz D; Littman DR_  
1998 Sep 1;248(2):357-371, Virology  
— id: 7599, year: 1998, vol: 248, page: 357, stat: Journal Article, 

**The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development**  
 _Irie HY; Mong MS; Itano A; Crooks ME; Littman DR; Burakoff SJ; Robey E_  
1998 Jul 1;161(1):183-191, Journal of immunology (1950)  
— id: 7614, year: 1998, vol: 161, page: 183, stat: Journal Article, 

**Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus**  
 _Langlois AJ; Desrosiers RC; Lewis MG; KewalRamani VN; Littman DR; Zhou JY; Manson K; Wyand MS; Bolognesi DP; Montefiori DC_  
1998 Aug;72(8):6950-6955, Journal of virology  
— id: 57190, year: 1998, vol: 72, page: 6950, stat: Journal Article, 

**Chemokine receptors: keys to AIDS pathogenesis?**  
_Littman DR_  
1998 May 29;93(5):677-680, Cell  
— id: 12106, year: 1998, vol: 93, page: 677, stat: Journal Article, 

**Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32**  
 _Michael NL; Nelson JA; KewalRamani VN; Chang G; O'Brien SJ; Mascola JR; Volsky B; Louder M; White GC 2nd; Littman DR; Swanstrom R; O'Brien TR_  
1998 Jul;72(7):6040-6047, Journal of virology  
— id: 57343, year: 1998, vol: 72, page: 6040, stat: Journal Article, 

**Regulation of IL-4 expression by activation of individual alleles**  
 _Riviere I; Sunshine MJ; Littman DR_  
1998 Aug;9(2):217-228, Immunity  
— id: 57232, year: 1998, vol: 9, page: 217, stat: Journal Article, 

**Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage**  
 _Trkola A; Ketas T; Kewalramani VN; Endorf F; Binley JM; Katinger H; Robinson J; Littman DR; Moore JP_  
1998 Mar;72(3):1876-1885, Journal of virology  
— id: 15118, year: 1998, vol: 72, page: 1876, stat: Journal Article, 

**Differences in chemokine coreceptor usage between genetic subtypes of HIV-1**  
 _Tscherning C; Alaeus A; Fredriksson R; Bjorndal A; Deng H; Littman DR; Fenyo EM; Albert J_  
1998 Feb 15;241(2):181-188, Virology  
— id: 7978, year: 1998, vol: 241, page: 181, stat: Journal Article, 

**G protein-coupled receptors in HIV and SIV entry: new perspectives on lentivirus-host interactions and on the utility of animal models**  
 _Unutmaz D; KewalRamani VN; Littman DR_  
1998 Jun;10(3):225-236, Seminars in immunology  
— id: 7833, year: 1998, vol: 10, page: 225, stat: Journal Article, 

**Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro**  
 _Zhang YJ; Dragic T; Cao Y; Kostrikis L; Kwon DS; Littman DR; KewalRamani VN; Moore JP_  
1998 Nov;72(11):9337-9344, Journal of virology  
— id: 57289, year: 1998, vol: 72, page: 9337, stat: Journal Article, 

**Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development**  
 _Zou YR; Kottmann AH; Kuroda M; Taniuchi I; Littman DR_  
1998 Jun 11;393(6685):595-599, Nature  
— id: 57298, year: 1998, vol: 393, page: 595, stat: Journal Article, 

**Antiviral immune responses in Itk-deficient mice**  
 _Bachmann MF; Littman DR; Liao XC_  
1997 Oct;71(10):7253-7257, Journal of virology  
— id: 15121, year: 1997, vol: 71, page: 7253, stat: Journal Article, 

**Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype**  
 _Bjorndal A; Deng H; Jansson M; Fiore JR; Colognesi C; Karlsson A; Albert J; Scarlatti G; Littman DR; Fenyo EM_  
1997 Oct;71(10):7478-7487, Journal of virology  
— id: 15120, year: 1997, vol: 71, page: 7478, stat: Journal Article, 

**Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5**  
 _Davis CB; Dikic I; Unutmaz D; Hill CM; Arthos J; Siani MA; Thompson DA; Schlessinger J; Littman DR_  
1997 Nov 17;186(10):1793-1798, Journal of experimental medicine  
— id: 12196, year: 1997, vol: 186, page: 1793, stat: Journal Article, 

**Expression cloning of new receptors used by simian and human immunodeficiency viruses**  
 _Deng HK; Unutmaz D; KewalRamani VN; Littman DR_  
1997 Jul 17;388(6639):296-300, Nature  
— id: 56936, year: 1997, vol: 388, page: 296, stat: Journal Article, 

**An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells**  
 _Ellmeier W; Sunshine MJ; Losos K; Hatam F; Littman DR_  
1997 Oct;7(4):537-547, Immunity  
— id: 12237, year: 1997, vol: 7, page: 537, stat: Journal Article, 

**Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor**  
 _Hill CM; Deng H; Unutmaz D; Kewalramani VN; Bastiani L; Gorny MK; Zolla-Pazner S; Littman DR_  
1997 Sep;71(9):6296-6304, Journal of virology  
— id: 57413, year: 1997, vol: 71, page: 6296, stat: Journal Article, 

**Itk negatively regulates induction of T cell proliferation by CD28 costimulation**  
 _Liao XC; Fournier S; Killeen N; Weiss A; Allison JP; Littman DR_  
1997 Jul 21;186(2):221-228, Journal of experimental medicine  
— id: 15123, year: 1997, vol: 186, page: 221, stat: Journal Article, 

**Itk and Fyn make independent contributions to T cell activation**  
 _Liao XC; Littman DR; Weiss A_  
1997 Dec 15;186(12):2069-2073, Journal of experimental medicine  
— id: 7658, year: 1997, vol: 186, page: 2069, stat: Journal Article, 

**Cell and viral regulatory elements enhance the expression and function of a human immunodeficiency virus inhibitory gene**  
 _Ranga U; Woffendin C; Yang ZY; Xu L; Verma S; Littman DR; Nabel GJ_  
1997 Sep;71(9):7020-7029, Journal of virology  
— id: 15122, year: 1997, vol: 71, page: 7020, stat: Journal Article, 

**In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression**  
 _Scarlatti G; Tresoldi E; Bjorndal A; Fredriksson R; Colognesi C; Deng HK; Malnati MS; Plebani A; Siccardi AG; Littman DR; Fenyo EM; Lusso P_  
1997 Nov;3(11):1259-1265, Nature medicine  
— id: 15119, year: 1997, vol: 3, page: 1259, stat: Journal Article, 

**CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells**  
 _Teh SJ; Killeen N; Tarakhovsky A; Littman DR; Teh HS_  
1997 Feb 15;89(4):1308-1318, Blood  
— id: 15124, year: 1997, vol: 89, page: 1308, stat: Journal Article, 

**Expression pattern of HIV-1 coreceptors on T cells: implications for viral transmission and lymphocyte homing**  
 _Unutmaz D; Littman DR_  
1997 Mar 4;94(5):1615-1618, Proceedings of the National Academy of Sciences of the United States of America  
— id: 12356, year: 1997, vol: 94, page: 1615, stat: Journal Article, 

**Identification of a major co-receptor for primary isolates of HIV-1**  
 _Deng H; Liu R; Ellmeier W; Choe S; Unutmaz D; Burkhart M; Di Marzio P; Marmon S; Sutton RE; Hill CM; Davis CB; Peiper SC; Schall TJ; Littman DR; Landau NR_  
1996 Jun 20;381(6584):661-666, Nature  
— id: 57390, year: 1996, vol: 381, page: 661, stat: Journal Article, 

**Natural resistance to HIV?**  
_Hill CM; Littman DR_  
1996 Aug 22;382(6593):668-669, Nature  
— id: 57364, year: 1996, vol: 382, page: 668, stat: Journal Article, 

**The regulation and function of the CD4 coreceptor during T lymphocyte development**  
 _Killeen N; Littman DR_  
1996 ;205:89-106, Current topics in microbiology & immunology  
— id: 15128, year: 1996, vol: 205, page: 89, stat: Journal Article, 

**The CD4 molecule. Roles in T lymphocytes and in HIV disease. Introduction**  
 _Littman DR_  
1996 ;205:v-x, Current topics in microbiology & immunology  
— id: 15129, year: 1996, vol: 205, page: v, stat: Journal Article, 

**Broad host range of human T-cell leukemia virus type 1 demonstrated with an improved pseudotyping system**  
 _Sutton RE; Littman DR_  
1996 Oct;70(10):7322-7326, Journal of virology  
— id: 15125, year: 1996, vol: 70, page: 7322, stat: Journal Article, 

**Studies of HIV-1 envelope glycoprotein-mediated fusion using a simple fluorescence assay**  
 _Weiss CD; Barnett SW; Cacalano N; Killeen N; Littman DR; White JM_  
1996 Mar;10(3):241-246, AIDS  
— id: 15126, year: 1996, vol: 10, page: 241, stat: Journal Article, 

**Inhibition of thymocyte negative selection by T cell receptor antagonist peptides**  
 _Williams O; Tanaka Y; Bix M; Murdjeva M; Littman DR; Kioussis D_  
1996 Mar;26(3):532-538, European journal of immunology  
— id: 15127, year: 1996, vol: 26, page: 532, stat: Journal Article, 

**The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4**  
 _Benkirane M; Schmid-Antomarchi H; Littman DR; Hirn M; Rossi B; Devaux C_  
1995 Nov;69(11):6904-6910, Journal of virology  
— id: 15132, year: 1995, vol: 69, page: 6904, stat: Journal Article, 

**CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation**  
 _Crooks ME; Littman DR; Carter RH; Fearon DT; Weiss A; Stein PH_  
1995 Dec;15(12):6820-6828, Molecular & cellular biology  
— id: 15131, year: 1995, vol: 15, page: 6820, stat: Journal Article, 

**Disrupted development of thymocytes expressing a transgenic TCR upon CD4 overexpression**  
 _Davis CB; Littman DR_  
1995 Dec;7(12):1977-1986, International immunology  
— id: 12705, year: 1995, vol: 7, page: 1977, stat: Journal Article, 

**Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules**  
 _Golding H; Dimitrov DS; Manischewitz J; Broder CC; Robinson J; Fabian S; Littman DR; Lapham CK_  
1995 Oct;69(10):6140-6148, Journal of virology  
— id: 15133, year: 1995, vol: 69, page: 6140, stat: Journal Article, 

**The function of the CD4 coreceptor in the development of T cells**  
 _Killeen N; Littman DR_  
1995 ;13(1):15-27, International reviews of immunology  
— id: 15134, year: 1995, vol: 13, page: 15, stat: Journal Article, 

**Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk**  
 _Liao XC; Littman DR_  
1995 Dec;3(6):757-769, Immunity  
— id: 15130, year: 1995, vol: 3, page: 757, stat: Journal Article, 

**The kinase-dependent function of Lck in T-cell activation requires an intact site for tyrosine autophosphorylation**  
 _Xu H; Littman DR_  
1995 Sep 7;766:99-116, Annals of the New York Academy of Sciences  
— id: 57371, year: 1995, vol: 766, page: 99, stat: Journal Article, 

**A subset of CD4+ thymocytes selected by MHC class I molecules**  
 _Bendelac A; Killeen N; Littman DR; Schwartz RH_  
1994 Mar 25;263(5154):1774-1778, Science  
— id: 15141, year: 1994, vol: 263, page: 1774, stat: Journal Article, 

**Requirement for kinase activity of CD4-associated p56lck in antibody-triggered T cell signal transduction**  
 _Chu K; Littman DR_  
1994 Sep 30;269(39):24095-24101, Journal of biological chemistry  
— id: 15135, year: 1994, vol: 269, page: 24095, stat: Journal Article, 

**Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain**  
 _Crooks ME; Littman DR_  
1994 Jul;1(4):277-285, Immunity  
— id: 15137, year: 1994, vol: 1, page: 277, stat: Journal Article, 

**Thymocyte lineage commitment: is it instructed or stochastic?**  
_Davis CB; Littman DR_  
1994 Apr;6(2):266-272, Current opinion in immunology  
— id: 15139, year: 1994, vol: 6, page: 266, stat: Journal Article, 

**Lymphocyte development in genetically manipulated mice**  
 _Killeen N; Littman DR_  
1994 Apr;1(2):123-133, Therapeutic immunology  
— id: 15140, year: 1994, vol: 1, page: 123, stat: Journal Article, 

**Immunodeficiency viruses. Not enough sans Nef**  
 _Littman DR_  
1994 Jul 1;4(7):618-620, Current biology. CB  
— id: 15136, year: 1994, vol: 4, page: 618, stat: Journal Article, 

**Signal transduction during T cell development**  
 _Littman DR; Davis CB; Killeen N; Xu H_  
1994 ;365:63-71, Advances in experimental medicine & biology  
— id: 15143, year: 1994, vol: 365, page: 63, stat: Journal Article, 

**CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi**  
 _Rajan TV; Nelson FK; Killeen N; Shultz LD; Yates JA; Bailis JM; Littman DR; Greiner DL_  
1994 Jun;78(4):352-360, Experimental parasitology  
— id: 15138, year: 1994, vol: 78, page: 352, stat: Journal Article, 

**A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development**  
 _Sawada S; Scarborough JD; Killeen N; Littman DR_  
1994 Jun 17;77(6):917-929, Cell  
— id: 57506, year: 1994, vol: 77, page: 917, stat: Journal Article, 

**Signal transduction by lymphocyte antigen receptors**  
 _Weiss A; Littman DR_  
1994 Jan 28;76(2):263-274, Cell  
— id: 15142, year: 1994, vol: 76, page: 263, stat: Journal Article, 

**Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes [see comments]**  
_Davis CB; Killeen N; Crooks ME; Raulet D; Littman DR_  
1993 Apr 23;73(2):237-247, Cell  
— id: 15151, year: 1993, vol: 73, page: 237, stat: Journal Article, 

**Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glycoprotein does occur after a long lag time**  
 _Golding H; Blumenthal R; Manischewitz J; Littman DR; Dimitrov DS_  
1993 Nov;67(11):6469-6475, Journal of virology  
— id: 15144, year: 1993, vol: 67, page: 6469, stat: Journal Article, 

**CD4 function in thymocyte differentiation and T cell activation**  
 _Killeen N; Davis CB; Chu K; Crooks ME; Sawada S; Scarborough JD; Boyd KA; Stuart SG; Xu H; Littman DR_  
1993 Oct 29;342(1299):25-34, Philosophical transactions of the Royal Society of London. Series B. Biological sciences  
— id: 15145, year: 1993, vol: 342, page: 25, stat: Journal Article, 

**Helper T-cell development in the absence of CD4-p56lck association**  
 _Killeen N; Littman DR_  
1993 Aug 19;364(6439):729-732, Nature  
— id: 15149, year: 1993, vol: 364, page: 729, stat: Journal Article, 

**Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4**  
 _Killeen N; Sawada S; Littman DR_  
1993 Apr;12(4):1547-1553, EMBO journal  
— id: 15152, year: 1993, vol: 12, page: 1547, stat: Journal Article, 

**Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice**  
 _Locksley RM; Reiner SL; Hatam F; Littman DR; Killeen N_  
1993 Sep 10;261(5127):1448-1451, Science  
— id: 15146, year: 1993, vol: 261, page: 1448, stat: Journal Article, 

**A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines**  
 _Sawada S; Littman DR_  
1993 Sep;13(9):5620-5628, Molecular & cellular biology  
— id: 15147, year: 1993, vol: 13, page: 5620, stat: Journal Article, 

**A kinase-independent function of Lck in potentiating antigen-specific T cell activation**  
 _Xu H; Littman DR_  
1993 Aug 27;74(4):633-643, Cell  
— id: 15148, year: 1993, vol: 74, page: 633, stat: Journal Article, 

**Truncation of the cytoplasmic domain of the simian immunodeficiency virus envelope glycoprotein increases env incorporation into particles and fusogenicity and infectivity**  
 _Zingler K; Littman DR_  
1993 May;67(5):2824-2831, Journal of virology  
— id: 15150, year: 1993, vol: 67, page: 2824, stat: Journal Article, 

**Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells**  
 _Killeen N; Moriarty A; Teh HS; Littman DR_  
1992 Jul 1;176(1):89-97, Journal of experimental medicine  
— id: 15155, year: 1992, vol: 176, page: 89, stat: Journal Article, 

**Development and function of T cells in mice with a disrupted CD2 gene**  
 _Killeen N; Stuart SG; Littman DR_  
1992 Dec;11(12):4329-4336, EMBO journal  
— id: 15153, year: 1992, vol: 11, page: 4329, stat: Journal Article, 

**Packaging system for rapid production of murine leukemia virus vectors with variable tropism**  
 _Landau NR; Littman DR_  
1992 Aug;66(8):5110-5113, Journal of virology  
— id: 15154, year: 1992, vol: 66, page: 5110, stat: Journal Article, 

**Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity**  
 _Page KA; Stearns SM; Littman DR_  
1992 Jan;66(1):524-533, Journal of virology  
— id: 15158, year: 1992, vol: 66, page: 524, stat: Journal Article, 

**The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits**  
 _Pelchen-Matthews A; Boulet I; Littman DR; Fagard R; Marsh M_  
1992 Apr;117(2):279-290, Journal of cell biology  
— id: 15156, year: 1992, vol: 117, page: 279, stat: Journal Article, 

**Differential involvement of protein tyrosine kinases p56lck and p59fyn in T cell development**  
 _van Oers NS; Garvin AM; Cooke MP; Davis CB; Littman DR; Perlmutter RM; Teh HS_  
1992 ;323:89-99, Advances in experimental medicine & biology  
— id: 15159, year: 1992, vol: 323, page: 89, stat: Journal Article, 

**Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck**  
 _Van Oers NS; Garvin AM; Davis CB; Forbush KA; Carlow DA; Littman DR; Perlmutter RM; Teh HS_  
1992 Mar;22(3):735-743, European journal of immunology  
— id: 15157, year: 1992, vol: 22, page: 735, stat: Journal Article, 

**Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells**  
 _Glaichenhaus N; Shastri N; Littman DR; Turner JM_  
1991 Feb 8;64(3):511-520, Cell  
— id: 15164, year: 1991, vol: 64, page: 511, stat: Journal Article, 

**Glycosylphosphatidylinositol-anchored CD4/Thy-1 chimeric molecules serve as human immunodeficiency virus receptors in human, but not mouse, cells and are modulated by gangliosides**  
 _Jasin M; Page KA; Littman DR_  
1991 Jan;65(1):440-444, Journal of virology  
— id: 15167, year: 1991, vol: 65, page: 440, stat: Journal Article, 

**Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range**  
 _Landau NR; Page KA; Littman DR_  
1991 Jan;65(1):162-169, Journal of virology  
— id: 15166, year: 1991, vol: 65, page: 162, stat: Journal Article, 

**BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias**  
 _Muller AJ; Young JC; Pendergast AM; Pondel M; Landau NR; Littman DR; Witte ON_  
1991 Apr;11(4):1785-1792, Molecular & cellular biology  
— id: 15163, year: 1991, vol: 11, page: 1785, stat: Journal Article, 

**Several CD4 domains can play a role in human immunodeficiency virus infection in cells**  
 _Poulin L; Evans LA; Tang SB; Barboza A; Legg H; Littman DR; Levy JA_  
1991 Sep;65(9):4893-4901, Journal of virology  
— id: 15162, year: 1991, vol: 65, page: 4893, stat: Journal Article, 

**Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene**  
 _Sawada S; Littman DR_  
1991 Nov;11(11):5506-5515, Molecular & cellular biology  
— id: 15160, year: 1991, vol: 11, page: 5506, stat: Journal Article, 

**Participation of CD4 coreceptor molecules in T-cell repertoire selection**  
 _Teh HS; Garvin AM; Forbush KA; Carlow DA; Davis CB; Littman DR; Perlmutter RM_  
1991 Jan 17;349(6306):241-243, Nature  
— id: 15165, year: 1991, vol: 349, page: 241, stat: Journal Article, 

**The thymus leukemia antigen binds human and mouse CD8**  
 _Teitell M; Mescher MF; Olson CA; Littman DR; Kronenberg M_  
1991 Nov 1;174(5):1131-1138, Journal of experimental medicine  
— id: 15161, year: 1991, vol: 174, page: 1131, stat: Journal Article, 

**Analysis of the site in CD4 that binds to the HIV envelope glycoprotein**  
 _Brodsky MH; Warton M; Myers RM; Littman DR_  
1990 Apr 15;144(8):3078-3086, Journal of immunology (1950)  
— id: 15170, year: 1990, vol: 144, page: 3078, stat: Journal Article, 

**Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity**  
 _Page KA; Landau NR; Littman DR_  
1990 Nov;64(11):5270-5276, Journal of virology  
— id: 15168, year: 1990, vol: 64, page: 5270, stat: Journal Article, 

**A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2**  
 _Salter RD; Benjamin RJ; Wesley PK; Buxton SE; Garrett TP; Clayberger C; Krensky AM; Norment AM; Littman DR; Parham P_  
1990 May 3;345(6270):41-46, Nature  
— id: 15169, year: 1990, vol: 345, page: 41, stat: Journal Article, 

**Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs**  
 _Turner JM; Brodsky MH; Irving BA; Levin SD; Perlmutter RM; Littman DR_  
1990 Mar 9;60(5):755-765, Cell  
— id: 15171, year: 1990, vol: 60, page: 755, stat: Journal Article, 

**Role of cell-to-cell interactions in T lymphocyte development and activation**  
 _Littman DR_  
1989 Oct;1(5):920-928, Current opinion in cell biology  
— id: 15172, year: 1989, vol: 1, page: 920, stat: Journal Article, 

**Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene**  
 _Norment AM; Lonberg N; Lacy E; Littman DR_  
1989 May 1;142(9):3312-3319, Journal of immunology (1950)  
— id: 15173, year: 1989, vol: 142, page: 3312, stat: Journal Article, 

**Diversity of class I HLA molecules: functional and evolutionary interactions with T cells**  
 _Parham P; Benjamin RJ; Chen BP; Clayberger C; Ennis PD; Krensky AM; Lawlor DA; Littman DR; Norment AM; Orr HT; et al_  
1989 ;54 Pt 1:529-543, Cold Spring Harbor symposia on quantitative biology  
— id: 15176, year: 1989, vol: 54 Pt 1, page: 529, stat: Journal Article, 

**Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8**  
 _Salter RD; Norment AM; Chen BP; Clayberger C; Krensky AM; Littman DR; Parham P_  
1989 Mar 23;338(6213):345-347, Nature  
— id: 15174, year: 1989, vol: 338, page: 345, stat: Journal Article, 

**Viral receptors of the immunoglobulin superfamily**  
 _White JM; Littman DR_  
1989 Mar 10;56(5):725-728, Cell  
— id: 15175, year: 1989, vol: 56, page: 725, stat: Journal Article, 

**Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4**  
 _Bedinger P; Moriarty A; von Borstel RC 2d; Donovan NJ; Steimer KS; Littman DR_  
1988 Jul 14;334(6178):162-165, Nature  
— id: 15181, year: 1988, vol: 334, page: 162, stat: Journal Article, 

**Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression**  
 _Kaldjian E; McCarthy SA; Sharrow SO; Littman DR; Klausner RD; Singer A_  
1988 Sep;2(12):2801-2806, FASEB journal  
— id: 15180, year: 1988, vol: 2, page: 2801, stat: Journal Article, 

**The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4**  
 _Landau NR; Warton M; Littman DR_  
1988 Jul 14;334(6178):159-162, Nature  
— id: 57528, year: 1988, vol: 334, page: 159, stat: Journal Article, 

**Corrected CD4 sequence**  
 _Littman DR; Maddon PJ; Axel R_  
1988 Nov 18;55(4):541-541, Cell  
— id: 15177, year: 1988, vol: 55, page: 541, stat: Journal Article, 

**Mouse brain CD4 transcripts encode only the COOH-terminal half of the protein**  
 _Lonberg N; Gettner SN; Lacy E; Littman DR_  
1988 May;8(5):2224-2228, Molecular & cellular biology  
— id: 15182, year: 1988, vol: 8, page: 2224, stat: Journal Article, 

**Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes**  
 _Newgard CB; Littman DR; van Genderen C; Smith M; Fletterick RJ_  
1988 Mar 15;263(8):3850-3857, Journal of biological chemistry  
— id: 15183, year: 1988, vol: 263, page: 3850, stat: Journal Article, 

**A second subunit of CD8 is expressed in human T cells**  
 _Norment AM; Littman DR_  
1988 Nov;7(11):3433-3439, EMBO journal  
— id: 15179, year: 1988, vol: 7, page: 3433, stat: Journal Article, 

**Cell-cell adhesion mediated by CD8 and MHC class I molecules**  
 _Norment AM; Salter RD; Parham P; Engelhard VH; Littman DR_  
1988 Nov 3;336(6194):79-81, Nature  
— id: 15178, year: 1988, vol: 336, page: 79, stat: Journal Article, 

**Patterns of T cell receptor gamma gene rearrangement and expression in B and T lymphoid malignancies**  
 _Subar M; Giuseppe Pelicci P; Neri A; Allavena P; Littman DR; Knowles DM 2d; Dalla-Favera R_  
1988 Jan;2(1):19-26, Leukemia  
— id: 11261, year: 1988, vol: 2, page: 19, stat: Journal Article, 

**The structure of the CD4 and CD8 genes**  
 _Littman DR_  
1987 ;5:561-584, Annual review of immunology  
— id: 15188, year: 1987, vol: 5, page: 561, stat: Journal Article, 

**Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene**  
 _Littman DR; Gettner SN_  
1987 Jan 29-Feb 4;325(6103):453-455, Nature  
— id: 15187, year: 1987, vol: 325, page: 453, stat: Journal Article, 

**Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism**  
 _Littman DR; Newton M; Crommie D; Ang SL; Seidman JG; Gettner SN; Weiss A_  
1987 Mar 5-11;326(6108):85-88, Nature  
— id: 15186, year: 1987, vol: 326, page: 85, stat: Journal Article, 

**Identification and sequence of a fourth human T cell antigen receptor chain**  
 _Loh EY; Lanier LL; Turck CW; Littman DR; Davis MM; Chien YH; Weiss A_  
1987 Dec 10-16;330(6148):569-572, Nature  
— id: 15184, year: 1987, vol: 330, page: 569, stat: Journal Article, 

**Arrangements and rearrangements of the human T-cell receptor gamma gene**  
 _Pelicci PG; Neri A; Knowles DM 2d; Littman DR; Dalla-Favera R; Subar M_  
1987 ;511:232-245, Annals of the New York Academy of Sciences  
— id: 11425, year: 1987, vol: 511, page: 232, stat: Journal Article, 

**Molecular diversity of the human T-gamma constant region genes**  
 _Pelicci PG; Subar M; Weiss A; Dalla-Favera R; Littman DR_  
1987 Aug 28;237(4818):1051-1055, Science  
— id: 15185, year: 1987, vol: 237, page: 1051, stat: Journal Article, 

**The gene encoding the T-cell surface protein T4 is located on human chromosome 12**  
 _Isobe M; Huebner K; Maddon PJ; Littman DR; Axel R; Croce CM_  
1986 Jun;83(12):4399-4402, Proceedings of the National Academy of Sciences of the United States of America  
— id: 15189, year: 1986, vol: 83, page: 4399, stat: Journal Article, 

**The T4 glycoprotein is a cell-surface receptor for the AIDS virus**  
 _McDougal JS; Maddon PJ; Dalgleish AG; Clapham PR; Littman DR; Godfrey M; Maddon DE; Chess L; Weiss RA; Axel R_  
1986 ;51 Pt 2:703-711, Cold Spring Harbor symposia on quantitative biology  
— id: 15190, year: 1986, vol: 51 Pt 2, page: 703, stat: Journal Article, 

**The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes**  
 _Littman DR; Thomas Y; Maddon PJ; Chess L; Axel R_  
1985 Feb;40(2):237-246, Cell  
— id: 15192, year: 1985, vol: 40, page: 237, stat: Journal Article, 

**The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family**  
 _Maddon PJ; Littman DR; Godfrey M; Maddon DE; Chess L; Axel R_  
1985 Aug;42(1):93-104, Cell  
— id: 15191, year: 1985, vol: 42, page: 93, stat: Journal Article, 

**Structural comparison of murine Ia antigens determined by the I-A and I-E subregions**  
 _Cullen SE; Kindle CS; Littman DR_  
1979 Mar;122(3):855-859, Journal of immunology (1950)  
— id: 15193, year: 1979, vol: 122, page: 855, stat: Journal Article, 

**Insertion of Ia and H-2 alloantigens into model membranes**  
 _Littman DR; Cullen SE; Schwartz BD_  
1979 Feb;76(2):902-906, Proceedings of the National Academy of Sciences of the United States of America  
— id: 15194, year: 1979, vol: 76, page: 902, stat: Journal Article, 

**Properties of the depolymerization products of microtubules from mammalian brain**  
 _Weingarten MD; Suter MM; Littman DR; Kirschner MW_  
1974 Dec 31;13(27):5529-5537, Biochemistry  
— id: 15195, year: 1974, vol: 13, page: 5529, stat: Journal Article,