AGRIS - 

2024

Svetlana N., Potapova | Ilnur R., Kadikov | Ekaterina I., Kurshakova | Danil R., Sagdeev

Introduction. In the development of iron deficiency anemia, a certain role is assigned to the effects of cadmium, whose pollution has a significant impact on the environment and public health. Once in the human and animal bodies, free cadmium ions contribute to the formation of reactive oxygen species, damaging liver and kidney tissue. This disrupts the metabolism of vital elements, including iron, heme synthesis and erythropoietin production. Cadmium-induced iron deficiency leads to a decrease in its intake into the bone marrow, as a result of which the synthesis of hemoglobin and erythrocytes is disrupted, anemia develops. Materials and methods. The studies were conducted on 36 laboratory rats, which were divided into 3 groups of 12 individuals each. The first group was a biological control, the second received CdCl2 daily with feed at the rate of 0.12 mg/kg of body weight (bw), the third received CdCl2 at the same dose as the animals of the second group, as well as ZnCl2 at a dose of 25 mg/kg of bw, Mg(NO3)2 – 10 mg/kg of bw, Na2SeO3 – 150 mcg/l of drinking water, methionine – 10 mg/kg of bw and Alfasorb – 1 % of the diet. Results and discussion. A study of the levels of erythrocytes, their average volume and hemoglobin in the blood of rats exposed to cadmium revealed the gradual development of anemia. While in the rats of the third group, which additionally received zinc, magnesium, selenium salts, methionine and Alfasorb in the diet, signs of anemia developed less pronounced. At the same time, the level of malondialdehyde in the blood of animals decreased, and the number of sulfhydryl groups increased. Conclusion. Taken together, the data obtained indicates the protective role of the components used against the effects of cadmium, characterized by a decrease in metal intake, its accumulation in internal organs, as well as the prevention of anemia.

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Mari State University - Russian Federation

2023

Dzhumaev, R. | Musheer, Mohd | Dzhumaeva, N.

Research relevance: the relevance of the data presented in the article lies in the study of the possible negative consequences of an unbalanced vegetarian diet of foreign students from India on the territory of Kyrgyzstan. Research purpose: the study of a possible deficiency in the absence of animal food in the diet and the consequences of these deficits, as well as the study of statistical data on the nutrition of the population and the prevalence of diseases associated with the considered deficiencies in India and Kyrgyzstan. Research materials and methods: a literature review was made on the effect of a vegetarian diet on protein-energy and vitamin-mineral deficiencies in the body of students from India. Research results: in India, the prevalence of various types of anemia is about 40%. Iron deficiency anemia predominates at 28% in 2019. Despite the fact that the reported cases of vitamin A deficiency in India are about 0.4%, diseases associated with deterioration and loss of vision are very common (about 13%). Conclusion: an unbalanced vegetarian diet is a source of a high risk of developing serious diseases, which is fraught with gross metabolic disorders in the body. | Актуальность приведенных в статье данных заключается в изучении возможных негативных последствий несбалансированной вегетарианской диеты студентов-иностранцев из Индии на территории Кыргызстана. Цели исследования: изучение возможного дефицита при недостатке в рационе животной пищи и последствия данных дефицитов, а также изучение статистических данных о питании населения и распространенности заболеваний, связанных с рассмотренными дефицитами, в Индии и Кыргызстане. Материалы и методы исследования: произведен литературный обзор о влиянии вегетарианской диеты на белково-энергетическую и витаминно-минеральную недостаточность в организме студентов из Индии. Результаты исследования: в Индии распространенность различных видов анемий составляют около 40%. Железодефицитная анемия преобладает на 28% за 2019 год. Несмотря на то, что зарегистрированных случаев дефицита витамина A в Индии около 0,4%, сильно распространены болезни, связанные с ухудшением и потерей зрения (около 13%). Выводы: несбалансированная вегетарианская диета является источником большого риска развития тяжелых заболеваний, что чревато грубыми нарушениями метаболизма в организме.

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Publishing center Science and Practice - Russian Federation

2023

Vostroilova, G.A. | Parshin, P.A. | Zhukov, M.S. | Khokhlova, N.A. | Shabanov, D.I. | Korchagina, A.A.

The research purpose was to study the effect of gestational age on the state of the enzymatic link of antioxidant protection (AOP) and formation of lipid peroxidation products (LPO) in cows with anemia syndrome and chronic systemic inflammation. Three groups of cows were formed: group I (n=15) – healthy; group II (n=8) – with hypochromic microcytic anemia; group III (n=7) – with low intensity chronic systemic inflammation syndrome. On days 150-160, 210-220 and 260-265 of gestation, blood samples were taken to study the indicators of LPO, AOP and endogenous intoxication. There were obtained data on the peculiarities of the state of the LPO-AOP system in cows with various clinical states during gestation. It has been established that there is a noticeable strength inverse correlation between the period of gestation and catalase activity. A significant direct correlation of high strength with respect to the level of nitric oxide has also been revealed. In cows with anemia, less intense tendencies for an increase in nitric oxide have been noted, which may have an important role in the control of fetoplacental hemodynamics and saturation of the fetal blood with oxygen. In group I and II, the level of diene conjugates had a significant direct correlation of noticeable strength, but in group III, the binding strength increased and became high, which was reflected at the level of average molecular weight molecules, detectable at a wavelength of 254 nm. Thus, with an increase in the gestation duration, there is an increase in the LPO intensity, which is most pronounced in cows with a syndrome of chronic systemic inflammation of low intensity, as a result of which endogenous intoxication develops. At the same time, nitric oxide is less actively produced in cows with anemia that can lead to the development of fetoplacental insufficiency and hypoxic state of the fetus. | Целью исследования явилось изучение влияния сроков беременности на состояние ферментативного звена антиоксидантной защиты (АОЗ) и образование продуктов перекисного окисления липидов (ПОЛ) у коров с синдромом анемии и хронического системного воспаления. Были сформированы 3 группы коров: группа I (n=15) – здоровые; группа II (n=8) –с гипохромной микроцитарной анемией; группа III (n=7) – с синдромом хронического системного воспаления низкой степени интенсивности. На 150-160, 210-220 и 260-265 дни стельности производили отбор проб крови для исследования показателей ПОЛ, АОЗ и эндогенной интоксикации. Получены данные об особенностях состояния системы ПОЛ-АОЗ у коров с разным клиническим состоянием во время беременности. Установлено, что между сроком стельности и активностью каталазы имеется обратная корреляционную связь заметной силы. Также выявлена достоверная прямая корреляционная связь высокой силы в отношении уровня оксида азота. У коров с анемией отмечены менее интенсивные тенденции увеличения оксида азота, что может иметь важную роль в контроле фетоплацентарной гемодинамики и насыщении крови плода кислородом. В группе I и II уровень диеновых конъюгатов имел достоверную прямую корреляционную связь заметной силы, но в группе III сила связи возрастала и становилась высокой, что отражалось на уровне молекул среднемолекулярной массы, определимых на длине волны 254 нм. Таким образом, с увеличением срока стельности происходит усиление интенсивности ПОЛ, которое наиболее выражено у коров с синдромом хронического системного воспаления низкой степени интенсивности, в результате чего у них появляется эндогенная интоксикация. Вместе с этим у коров с анемией менее активно вырабатывается оксид азота, что может привести к развитию фетоплацентарной недостаточности и гипоксическому состоянию плода.

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Central Scientific Agricultural Library - Russian Federation

2022

Tarlavin, N.V. | Veretennikov, V.V. | Dzhavadov, Eh.D. | Kraskov, D.A.

The immune response to vaccination is formed through the activation of gene expression processes in cells and tissues of various immunocompetent organs. Morphology of fabricii bursa, thymus and expression of immunity genes IRF7, PTGS2, IL8L2 were studied in commercial laying hens on the background of vaccination with live vaccines against infectious bursal disease and infectious anemia of chickens. In each experiment, an experimental (vaccinated) and a control (intact) group of chickens of 30 individuals each were formed. An immunocomplex vaccine from the strain "VNIVIP" was used against bursal disease, against infectious anemia of chickens - Nobilis CAVP4 vaccine produced by MSDAnimalHealth. In chickens vaccinated against bursal disease, changes were noted on the part of the fabricii bursa: its shape is oval, with folds protruding through the peritoneal cover, the cover itself is flabby, and the mucous membrane is hyperemic, spot hemorrhages are on the surface. The IL8L2 gene increased its expression 21.6 times, the PTGS2 gene by 26.6 times, and the IRF7 gene practically did not increase its expression. The thymus was examined in chickens vaccinated against infectious anemia. Spot hemorrhages were noted on its surface, the structure of the cortical layer was changed (replacement of thymus cells with adipocytes, fibroblasts, and other lymphoid cells). The IL8L2 gene increased expression 8.75 times, the gene PTGS2 - 22.94 times, and the IRF7 gene did not exceed expression compared to the control level. According to the results of the research, it has been concluded that the IL8L2 and PTGS2 genes responsible for the synthesis of inflammatory components are actively expressed when exposed to the cells of viruses of chicken infectious anemia and infectious bursal disease. The level of expression of the IRF7 gene in the immune organs of the experimental groups of chickens practically did not differ from those in the target organs of control birds due to the immunosuppressive effect of viruses. | Иммунный ответ на вакцинацию формируется посредством активации процессов экспрессии генов в клетках и тканях различных иммунокомпетентных органов. Исследовали морфологию фабрициевой сумки, тимуса и экспрессию генов иммунитета IRF7, PTGS2, IL8L2 у промышленных кур-несушек на фоне вакцинации живыми вакцинами против инфекционной бурсальной болезни и инфекционной анемии цыплят. В каждом эксперименте формировали опытную (вакцинируемую) и контрольную (интактную) группу цыплят по 30 особей в каждой. Против бурсальной болезни применяли иммунокомплексную вакцину из штамма "ВНИВИП", против инфекционной анемии цыплят - вакцину Нобилис CAVP4 производства MSDAnimalHealth. У цыплят, вакцинированных от бурсальной болезни, отмечены изменения со стороны фабрициевой сумки: её форма овальная, с проступающими через перитонеальный покров складками, сам покров дряблый, слизистая оболочка гиперемирована, на поверхности точечные кровоизлияния. Ген IL8L2 увеличил свою экспрессию в 21,6 раз, ген PTGS2 - в 26,6 раз, ген IRF7 экспрессию практически не увеличил. У цыплят, вакцинированных от инфекционной анемии, исследовали тимус. На его поверхности отмечены точечные кровоизлияния, изменена структура коркового слоя (замена клеток тимуса на адипоциты, фибробласты и др. лимфоидные клетки). Ген IL8L2 увеличил экспрессию в 8,75 раз, ген PTGS2 - в 22,94 раза, а ген IRF7 не превысил экспрессию по сравнению с уровнем контроля. По результатам исследований были сделаны выводы, что гены IL8L2 и PTGS2, отвечающие за синтез воспалительных компонентов, активно экспрессируются при воздействии на клетки вирусов инфекционной анемии цыплят и инфекционной бурсальной болезни. Уровень экспрессии гена IRF7 в иммунных органах опытных групп цыплят практически не отличался от такового в органах-мишенях контрольных птиц по причине иммунодепрессивного действия вирусов.

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Central Scientific Agricultural Library - Russian Federation

2022

Balakirev, N.A. | Del'tsov, A.A. | Pozyabin, S.V. | Maksimov, V.I.

Железо - эссенциальный микроэлемент, необходимый для осуществления многих процессов в организме (регуляция обмена веществ, синтез ДНК и АТФ, перенос кислорода, тканевое дыхание, эритропоэз, иммунный ответ). У пушных зверей клеточного содержания железодефицитная анемия приводит к значительным экономическим потерям вследствие снижения жизнеспособности и плодовитости, ухудшения качества получаемой пушнины. Цель исследования - экспериментальное моделирование железодефицитной анемии у лабораторных крыс, чтобы в будущем экстраполировать полученные на этой модели результаты на пушных зверей. Из 4-месячных белых беспородных нелинейных лабораторных крыс массой 200 г сформировали две группы по 10 особей. Контрольные животные получали общепринятый сбалансированный рацион, соответствующий нормам потребления для лабораторных крыс (белки - 4 г, жиры - 2 г, углеводы - 25 г, клетчатка - 0,5-1,0 г); в опытной группе специально разработанный рацион 4-кратно ограничивал поступление железа в организм, но соответствовал нормам кормления по содержанию питательных веществ, витаминов и минералов (исключая железо). После 45 сут у особей в опытной группе развивалась железодефицитная анемия: по сравнению с контролем (особи, получавшие бездефицитную по железу диета) в крови достоверно уменьшалось содержание гемоглобина, гематокрита, числа эритроцитов, концентрации сывороточного железа, среднего объема эритроцита, среднего содержания гемоглобина в эритроците, в эритроцитарной массе, регистрировалась гипохромия и микроцитоз. С 17-х сут эксперимента у животных отмечали одышку и учащение сердцебиения, с 24-х сут регистрировали понижение температуры. До 14-х сут цвет кожных покровов и слизистых оболочек, а также общее состояние животных в обеих группах соответствовали норме, после 14-х сут у крыс, получавших экспериментальный рацион с ограниченным содержанием железа, наблюдали анемичность кожного покрова и слизистых оболочек ротовой полости, а также вялость и угнетение общего состояния. | Iron is an essential trace element necessary for the implementation of many processes in the body. In caged fur animals, iron deficiency anemia leads to significant economic losses due to a decrease in viability and fertility, and deterioration in the fur quality. The aim of the study was experimental modeling of iron deficiency anemia in laboratory rats in order to extrapolate the results obtained on this model to fur animals in the future. From 4-month-old white outbred laboratory rats weighing 200 g, two groups of 10 individuals were formed. Control animals received a generally accepted balanced diet which corresponded to the consumption norms for laboratory rats and was 4 g proteins, 2 g fats, 25 g carbohydrates, and 0.5-1.0 g fiber. In the experimental group a specially developed diet was applied which was 4 times less in the iron content, but corresponded to the feeding norms in terms of the nutrients, vitamins and minerals (excluding iron). After 45 days, the rats in the experimental group developed iron deficiency anemia. As compared to the control rats, receiving a diet not deficient in iron, there was a significant decrease in hemoglobin, hematocrit, the number of erythrocytes, the concentration of serum iron, the average volume of erythrocyte, the average content of hemoglobin per erythrocyte, and per total erythrocyte matter. The anemia of the animals was hypochromi and macrocytic. From day 17 of the experiment, shortness of breath and increased heart rate occurred, from day 24, the body temperature decreased. Up to day 14, the color of the skin and mucous membranes, as well as the general condition of the rats in both groups corresponded to the norm. After day 14, anemic skin and mucous membranes of the oral cavity were observed in rats receiving an experimental iron-deficient diet. In addition, lethargy and general depression occurred.

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Central Scientific Agricultural Library - Russian Federation

2022

Savrasov, D.A. | Parshin, P.А.

There are presented the results of studying the therapeutic efficacy of a complex biogenic drug aminoseleferon-B representing a tissue biostimulant based on recombinant interferons. Holstein calves with comorbid pathology (hypotrophy, anemia, and immunodeficiency) were observed in the neonatal period. According to the principle of analogous pairs, 4 groups of 6 individuals in each group the 5-th group (6 heads) including clinically healthy animals (normotrophic calves) were formed, to compare aminoseleferon-B with other biostimulants. The calves of the 1-st experimental group received the tissue biostmulant aminoseleton, the 2-nd group - biferon-B, the 3-d group - the drug aminoseleferon-B. The drugs were administered subcutaneously, thrice on days 1, 3 and 30 at a dose of 1 ml per 10 kg of animal weight. The studied drugs were not administered to hypotrophic calves of the 4-th group and healthy calves of the 5-th group (positive control). In the calves of the 3-d group, stabilization of the morphological and immunological composition of the blood was noted earlier, on the 7-th day, whereas in the other groups the studied indicators were optimized only on the 30-th day. From the 7-th to the 30th days the level of erythrocytes increased by 9.3 and 6.4% in comparison with those in calves of the 4-th group. A similar pattern was noted in terms of total hemoglobin amount: on day 7 of the experiment the indicator increased by 13.7% and by the 30-th day by 7.7%. Humoral and cellular links of nonspecific immune protection were restored in the calves of the 3-d experimental group, due to normalization of serum compliment, lysozyme and bacterial activity of blood serum, phagocytic index and number. Of the tested drugs, aminoseleferon-B has shown the greatest activity; it has multimodal properties, has a pathogenetically mediated mechanism of action in the treatment of calves with hypotrophy, exhibits a pronounced anti-anemic and immunomodulatory effect, which together facilitates the condition of the calves' body during early neonatal adaptation. | Представлены результаты исследования терапевтической эффективности комплексного биогенного препарата аминоселеферон-Б, представляющего собой тканевый биостимулятор на основе рекомбинантных интерферонов. Наблюдали телят голштинской породы с коморбидной патологией (гипотрофия, анемия, иммунодефицит) в неонатальный период. Для сравнения аминоселеферона-Б с др. биостимуляторами по принципу пар-аналогов были скомплектованы 4 гр. по 6 гол. телят в каждой и 5-я гр. (6 гол.), в которую вошли клинически здоровые животные (нормотрофики). Телятам 1-й гр. применяли тканевый биостимулятор аминоселетон, 2-й гр. - иммуномодулятор биферон-Б, 3-й гр. - аминоселеферон-Б. Препараты вводились подкожно, трехкратно в первые, 3-и и 30-е сутки в дозе 1 мл/10 кг массы животного. Телятам-гипотрофикам 4-й гр. (отрицательный контроль) и здоровым телятам 5-й гр. (положительный контроль) изучаемые препараты не применялись. У телят 3-й гр. отмечали более раннюю стабилизацию морфологического и иммунологического состава крови, на 7-е сут. исследований, тогда как в остальных группах изучаемые показатели оптимизировались только на 30-е сут.; с 7-го по 30-й дн. повысился уровень содержания эритроцитов на 9,3 и 6,4% в сравнении с таковыми у телят 4-й гр. Аналогичная картина была отмечена и по количеству общего гемоглобина – на 7-е сут. показатель увеличился на 13,7% и к 30-му дн. опыта на 7,7%; восстанавливались гуморальные и клеточные звенья неспецифической защиты, за счет нормализации активности комплимента, лизоцима и бактериальной активности сыворотки крови, фагоцитарного индекса и числа. Из испытанных препаратов наибольшую активность проявил аминоселеферон-Б; он обладает мультимодальными свойствами, при лечении телят с гипотрофией имеет патогенетически-опосредованный механизм действия, проявляет выраженный противоанемический и иммуномодулирующий эффект, что в совокупности облегчает состояние организма телят в период ранней неонатальной адаптации.

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Central Scientific Agricultural Library - Russian Federation

2022

Savojskaya, S.L. | Sanin, A.V. | Ogorodnikova, I.V. | Kozhevnikova, T.N. | Narovlyanskij, A.N. | Pronin, A.V.

The purpose of the research is to study the effectiveness of Phosprenyl (PP), an mmunomodulator with antiviral activity (active ingredient - sodium polyprenyl phosphate), in the treatment of chronic coronavirus infection of cats, partially complicated by toxoplasmosis. A total of 117 cats were under observation, 10 of which also had toxoplasmosis. The diagnosis was confirmed by the determination of antibodies by the immunochromatographic assay (Lateral flow test) and enzyme-linked immunosorbent assay (ELISA), as well as by ultrasound investigation (U/S) of the abdominal organs. Prescribed treatment: PP per os, 1 ml twice a day, treatment course 2-4 months; Gamavit daily, s/c, course - 10 days, with a repeated course after 3 weeks; 3-4 times. As symptomatic therapy, drugs were used to improve the condition of the bowel movement, at toxoplasmosis - Fansidar. At the end of treatment symptoms of gastrointestinal tract damage disappeared in all the patients. If before the onset of therapy, the majority of patients demonstrated changes characteristic of anemia, then after 2-4 months, the indices of red blood shoot completely normalized. In patients with coronavirus infection complicated by toxoplasmosis, anemia was detected by CBC test, as well as an increase in the number of neutrophils. In the biochemical profile of these patients: increased activity of the enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT) was found as well as hyperbilirubinemia, which indicates greater liver damage and a decrease in its detoxification function during the course of the disease caused simultaneously by coronavirus and toxoplasmas. At the end of therapy, these indices also returned to normal. Thus, the use of PP for 2-4 months reduces the duration of the disease of coronavirus infection in cats (including cases complicated by toxoplasmosis), prevents its exacerbation and possible fatal outcome. Long-term use of PP in cats with a chronic form of coronavirus infection is recommended. | Цель исследования: изучить эффективность Фоспренила (ФП) - иммуномодулятора с противовирусной активностью (действующее вещество - полипренилфосфат натрия), при терапии хронической коронавирусной инфекции кошек, частично осложненной токсоплазмозом. Всего под наблюдением находилось 117 кошек, у 10 из которых был также выявлен токсоплазмоз. Диагноз подтверждали определением антител (использовали иммунохроматографический анализ - ИХА) и имммуноферментный анализ - ИФА), при посредстве ультразвукового исследования (УЗИ) органов брюшной полости. Назначенное лечение: ФП per os по 1 мл 2 раза в день, курс 2…4 месяца; гамавит 1 раз в день, подкожно, курс 10 дней, с повторением через 3 недели - 3…4 раза. В качестве симптоматической терапии использовали препараты для улучшения состояния стула, при токсоплазмозе - фансидар. По окончании лечения у всех пациентов наблюдали исчезновение симптомов поражения желудочно-кишечного тракта. Если до начала терапии у большинства пациентов отмечали изменения, характерные для анемии, то через 2…4 месяца показатели красного ростка гемопоэза полностью нормализовались. У пациентов с коронавирусной инфекцией, осложненной токсоплазмозом, при общем анализе крови выявляли анемию, а также увеличение количества нейтрофилов. В биохимическом профиле этих пациентов: повышение активности ферментов аспартатаминотрансферазы (АсАТ) и аланинаминотрансферазы (АлАТ) на фоне гипербилирубинемии, что свидетельствует о большем поражении печени и снижении ее детоксикационной функции при течении заболевания, вызванном одновременно коронавирусом и токсоплазмами. По окончании терапии данные показатели полностью нормализовались. Таким образом, применение ФП в течение 2…4 месяцев позволяет сократить длительность заболевания коронавирусной инфекцией у кошек (в том числе осложненной токсоплазмозом), предупреждает ее обострение и летальный исход. Рекомендовано длительное использование ФП у кошек с хронической формой коронавирусной инфекции.

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Central Scientific Agricultural Library - Russian Federation

2022

Khanyukov O. O. | Zaiats I. O.

. Coronary artery disease (CHD) is the most common cardiovascular disease in the world, the incidence of which increases with age. The prevalence of anemia also increases with age and is associated with a more severe condition in patients with CAD. This category of patients also has an increased risk of complications, including sudden cardiac death (RCD). Purpose: to evaluate the clinical and functional parameters of ischemia, the presence of pathological cardiac arrhythmias and the clinical efficacy of treatment with nitric oxide donors in patients with coronary artery disease and anemia. 95 patients with IHD were examined. The main group consisted of 53 IHD patients with iron deficiency anemia, which were divided into two subgroups. 24 patients of the first subgroup were recommended standard therapy for coronary artery disease and anemia. 29 patients of the second subgroup additionally took L-arginine. The control group consisted of 42 patients with coronary artery disease without anemia who received standard therapy. At the beginning of the study, the severity of ischemic changes and heart failure in patients of the main group was greater than in the control group. The median circadian heart rate index was less than normal in both groups, but in the main group this indicator was significantly lower. A greater average number of extraistols (both supraventricular and ventricular) was registered in the main group. The total number of patients with atrial fibrillation was also higher in the main group. During therapy, the indicator of «total ischemia burden» decreased in both groups and was comparable in the second subgroup (with L-arginine) and the control group (pk-2>0,05), but remained higher than the first subgroup (pk-1<0, 01; p1-2<0,05). The dynamics of the circadian index was similar: in all groups there was a decrease in CI HCC, but in the first subgroup the effect was lower than the control group and the second subgroup (pk-2>0,05; pk-1<0,01; p1-2<0,001). The number of extrasystoles decreased in both groups. The percentage of changes in the indicator of the number of extrasystoles in dynamics in the second subgroup was significantly higher than in the first, and then comparable with the indicator of the control group (pk-1<0,001; pk-2>0,05, pk-1<0,001).

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Directory of Open Access Journals - Sweden

2021

I. M. Derkach

Prevention of iron deficiency anemia in piglets is an important preventive measure to ensure the health of pigs, as mortality from this pathology is quite high, and animals that recover from treatment do not realize their own potential productivity. The aim of our study was to evaluate the effectiveness of the use of iron (IV) clatrochelate in combination with cyanocobalamin for the prevention of iron deficiency anemia in piglets compared to the traditional scheme of prevention of this disease. To achieve this goal, 2 groups of newborn piglets-analogues were formed during their retention with suckling sows – control and experimental, 15 animals in each. The experiment lasted 30 days. Piglets in the experimental group were selected from sows given 10 ml of 10 % iron (IV) clatrochelate solution and cyanocobalamin solution twice intramuscularly during pregnancy. Piglets of the control group according to the traditional scheme of prevention of iron deficiency anemia on the second day of life were administered iron dextran drug (at the rate of 200 mg of iron (III) per injection). The results of the study show that the body weight of piglets from 1 to 9 days of their life who are born from sows which used iron (IV) clatrochelate and cyanocobalamin during pregnancy was less (P < 0.001) than the body weight of piglets which used iron dextran on the 2nd day after birth; did not differ on the 12 day of life, but on the 30 day was higher than the body weight of piglets in the control group 1.15 times (P < 0.001). The level of protein in the serum of piglets of the experimental group from birth to 30 day of life  was probably higher compared to the control, which indicates that iron (IV) clatrochelate stimulates protein synthesis in the body. Therefore, double injection of 10 % solution of iron (IV) clatrochelate in a dose of 10 ml in combination with injections of cyanocobalamin at a dose of 500 mcg of active substance to pregnant sows pregnant sows 14 and 7 days before the expected farrowing provides a preventive effect of iron deficiency anemia in piglets born to them.

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Directory of Open Access Journals - Sweden

2021

Chhaya Gupta | Sushma Tiwari

Clinical research involves investigating proposed medical treatments, assessing the relative benefits of competing therapies, and establishing optimal treatment combinations. It is the most fruitful line of approach for methods of diagnosis and treatment as described in Ayurvedic literature. Anaemia is the most common indicator used to screen for iron deficiency, the terms anaemia, iron deficiency, and iron deficiency anaemia are sometimes used interchangeably. Iron deficiency anaemia would be considered a public health problem only when the prevalence of haemoglobin concentration exceeds 5.0% of the population. The prevalence of iron deficiency anaemia in a population is therefore a statistical rather than a physiological concept, although it reflects that proportion of the population that has iron-deficient erythropoiesis. As iron deficiency has been recognized as commonest nutritional deficiency disorder and a risk to the nation among top ten selected health risks, although this deficiency disorder has been described by the name Panduroga thousands of years ago in the Ayurvedic classics. Punarnava Mandura is an Ayurvedic iron preparation has been used for the management of this disease since that time. In the present study a clinical trial of Punarnava Mandura has been carried out for evaluating the better efficacy on Panduroga i.e., Iron deficiency anaemia. Study Drug Punarnava Mandura following the reference of Bhaishsjya Ratnavali was selected and its comparison was done with ferrous sulphate taken as a control.

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Directory of Open Access Journals - Sweden