Question: What artist painted the sets of watercolors that she made exploring a monochromatic palette with designs that were non-representational of specific objects, and was best known for her paintings of enlarged flowers? 
Facts:
Georgia Totto O'Keefe has sets of watercolors with monochromatic palettes and designs that were non-representational of specific objects
Georgia Totto O'Keeffe is known for paintings of enlarged flowers
Answer: Georgia Totto O'Keeffe