傅嫈惠

**傅嫈惠**（）是臺灣臺中豐原出身的美国華裔生物学家和人类遗传学家，國立中興大學食品科學、俄亥俄州立大學畢業，目前是加州大学旧金山分校的神经学教授，美国国家科学院院士。

## 生平
1980年取得国立中兴大学食品科学学位，1986年取得俄亥俄州立大学生物化学以及细胞生物学学位。之后，在俄亥俄州立大学和贝勒医学院从事了博士后研究，主要研究内容为人类基因组。她在业界工作过四年后，返回学术界担任犹他大学研究助理教授。2002年，在加州大学旧金山分校与合作者Louis Ptacek共同组建了实验室。

2018年，当选为美国国家科学院院士與中華民國中央研究院生命科學組院士。

## 部分出版物
# Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptáček LJ, Fu Y-H. An h''Per2'' phosphorylation site mutation in familial advanced sleep-phase syndrome. Science. 2001;291:1040-3.
# Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptáček LJ, Fu Y-H. Functional consequences of a ''CKIδ'' mutation causing familial advanced sleep phase syndrome. Nature. 2005;434:640-4.
# Padiath QS, Saigoh K, Schiffman R, Asahara H, Koeppen A, Hogan K, Ptáček LJ, Fu Y-H. *[https://www.ncbi.nlm.nih.gov/pubmed/?term=Padiath+QS%2C+Saigoh+K%2C+Schiffman+R%2C+Asahara+H%2C+Koeppen+A%2C+Hogan+K%2C+Pt%C3%A1%C4%8Dek+LJ%2C+Fu+Y-H.%C2%A0Lamin+B1%C2%A0duplications+cause+autosomal+dominant+leukodystrophy.%C2%A0Nat+Genet.+2006+Oct%C2%A0%3B+38(10)1114-23.+Epub+2006+Sep+3. Lamin B1]*[duplications cause autosomal dominant leukodystrophy](https://www.ncbi.nlm.nih.gov/pubmed/?term=Padiath+QS%2C+Saigoh+K%2C+Schiffman+R%2C+Asahara+H%2C+Koeppen+A%2C+Hogan+K%2C+Pt%C3%A1%C4%8Dek+LJ%2C+Fu+Y-H.%C2%A0Lamin+B1%C2%A0duplications+cause+autosomal+dominant+leukodystrophy.%C2%A0Nat+Genet.+2006+Oct%C2%A0%3B+38(10)1114-23.+Epub+2006+Sep+3.). Nat Genet. 2006 Oct ; 38(10)1114-23. Epub 2006 Sep 3.
# He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder J, Nishino S, and Fu Y-H. Transcriptional suppressor DEC2 is a Regulator for Human Sleep Homeostasis. Science. 2009 325:866.
# Fu, YH and Marzluf, GA. cys-3, the positive-acting sulfur regulatory gene of ''Neurospora crassa'', encodes a sequence-specific DNA-binding protein. *J Biol Chem*, 1990, **265**, 11942-11947.
# Fu, Y.H., Kuhl, D.P., Pizzuti, *et al.*  Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. *Cell*, 1991, **67**, 1047-1058.    
# Fu, Y.H., Pizzuti, A., Fenwick, R.G., Jr., *et al.*  An unstable triplet repeat in a gene related to myotonic muscular dystrophy. *Science*, 1992, **255**, 1256-1258.
# Yu, C.E., Oshima, J., Fu, Y.H., *et al.*  Positional cloning of the Werner's syndrome gene . *Science*, 1996, **272**, 258-262.
# Levy‑Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu C, Jondro PD, Schmidt SD, Wang K, Crowley AC, Fu Y-H, Guenette SY, Galas D, Nemens E, Wejsman EM, Bird TD, Schellenberg GD, Tanzi RE. Candidate gene for the chromosome 1 familial Alzheimer's disease locus.  *Science*, 1995 **269**, 973-977.
# Xu Y, Toh KL, Jones CR, Shin JY, Fu Y-H*, Ptáček LJ. Modeling of a human circadian mutation yields insights into clock regulation by PER2 . *Cell*. 2007 Jan 12:128(1):59-70.
# Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptáček LJ, Fu Y-H*. Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock.*Cell Metab*. 2013 Feb 5;17(2):291-302.
# Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptacek LJ. Casein kinase iδ Mutations in Familial Migraine and Advanced Sleep Phase .*Science Transitional Mag.* 2013 May 1; 183(5):183ra56.
# He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder J, Nishino S, and Fu Y-H. Transcriptional suppressor DEC2 is a Regulator for Human Sleep Homeostasis. Science. 2009 325:866.
# Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptácek LJ, **Fu YH**. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013 Feb 5; 17(2):291-302. ; .

## 参见
* 睡眠的神经科学

## 参考文献

## 外部链接
* Official profile at University of California 
* Official lab profile in collaboration with Louis Ptacek's lab at UCSF
* Fu's personal website