Antazoline

**Antazoline** nyaéta ubar antihistamin generasi kahiji kalayan aktivitas antikolinergik.  Antazoline disebut ogé *Otrivine-Antistin*, mangrupa ubar jinis anti inflamasi nu bisa  ngungkulan gejala sarta alergi. Salaku *dekongestan*, antazoline biasa dipaké pikeun ngungkulan irung mangpet, sarta mun diformulasikeun dina bentuk tétés panon, bisa ngubaran konjungtivitis alergik. Konjungtivitis alergik nyaéta réaksi paradangan dina panon ku sabab ayana kontak jeung subtansi alérgén kayaning kebul, bulu sato, bubuk sari kembang atawa spora jamur, atawa komponen kimia nu aya dina sababaraha produk. Gejala nu biasa karandapan kayaning, panon beureum, caian, ateul, jeung karasa nyeri.

## Struktur fisik 
Antazoline nyaéta ubar anti histamin generasi kahiji kalayan aktivitas antikolinergik. Antazoline miboga struktur kimia C17-H19-N3 nu miboga beurat molekul 265.35 gram/mol. Dina ngaran kimia N-Benzyl-N-(2-imidazolin-2-ylmetyl)aniline (BAN) 2-N-benzylanilinometylimidazoline (WHO).

Antazoline mangrupa antagonis réséptor H1. Sacara selektif ngabeungkeut réséptor H1 ngan teu di aktifkeun nepi ka ngahalangan histamin endogen jeung mampu ngurangan gejala negatip nu aya ku sabab histamin nu dileupaskeun. Leupasna histamin ieu ku sabab sistem awak nu nahankeun diri tina subtansi asing nu miboga poténsi nimbulkeun éfék goréng keur kaséhatan.

### Hal-hal nu kudu diperhatikeun 
Saacan maké antazoline kudu dikonsultasikeun heula ka dokter ngeunaan yuswa, kaayaan kaséhatan, panyakit nu karandapan sarta ubar jeung vitamin lianna nu keur dikonsumsi, kayaning:

* Mun anjeun keur maké *softlens*
* Miboga riwayat atawa miboga kasakit jantung jeung ogé tekanan darah tinggi
* Keur karandapan panyakit glaukoma sudut sempit
* Miboga alérgi kana jinis ubar keclak panon antazoline
* Mun anjeun keur kakandungan atawa miboga rencana rék hamil.
* Budak leutik handapeun 12 taun, ku sabab antazoline bisa dipaké ku budak minimal 12 taun.

Salian ti sababaraha hal éta, anjeun kudu ngajelaskeun ka dokter ubar naon waé nu keur dipaké boh ubar herbal, ubar komplementer atawa ubar ti warung. Paké antazoline saluyu jeung prosedur pamakéan nu saluyu. Mun dina 72 jam acan kénéh aya parobahan, gera konsultasikeun deui ka dokter.

## Ngaran lian 
Ieu di handap aya sababaraha ngaran luar, ngaran generik sarta ngaran dagang ti ubar antazoline:

### Ngaran luar 
* Antazolinum (Latin)
* Antazolin (Jérman)
* Antazoline (Prancis)
* Antazolina (Spanyol)

### Ngaran generik 
**Antazolina* (OS: DCIT)
**Antazoline* (OS: BAN, DCF)
* 5512-M (IS)
* M 5512 (IS)
* PM 265 (IS)
**Antazoline Hydrochloride* (OS: BANM)
**Phenazoline hydrochloride* (IS)
**Antazoline* (chlorhydrate d') (PH: Ph. Eur. 9)
**Antazoline Hydrochloride* (PH: BP 2018, USP XV)
**Antazoline hydrochloride* (PH: Ph. Eur. 9)
**Antazolinhydrochlorid* (PH: Ph. Eur. 9)
**Antazolini hydrochloridum* (PH: Ph. Eur. 9, Ph. Int. 2)
**Antazoline Mesylate* (IS)
**Antazoline methanesulfonate* (IS)
**Antazoline Phosphate* (OS: BANM)
**Antazoline Phosphate* (PH: USP 41)
**Antazoline Sulfate* (OS: BANM)
**Antazolina solfato* (PH: F.U. XII)

### Ngaran mérk dagang disababaraha nagara 
**Antistin Privina [+ Naphazoline]* Novartis Farma, Italia
**Antistin-Privin [+ Antazoline]* Novartis, Libanon
**Miracryl-A [+ Naphazoline] Roster*, Péru
**Oftalirio [+ Naphazoline]* Saval,Ékuador; Saval, Peru; Servimedic, Uruguay
**Optizolin [+ Tetryzoline*] Jamjom, Égypt
**Red Off Plus* [+ Naphazoline] Labolatorium Chili, Cilé
**Spersallerg [+ Tetryzoline] Excel Vision*, Libanon
**Zincfrin A [+ Zinc, + Naphazoline]* Alcon, Méksiko
**Zocare [+ Tetryzoline]* *Healthcare*, Bangladés
**Ankemin [+ Tetryzoline]* Union, Taiwan
**Antazallerge [+ Tetryzoline]* Siam Bheasach, Thailand
**Antistine CIBA*, Kuwait
**Apillerg [+ Tetryzoline] Amman Pharmaceutical*, Oman
**Curall-a [+ Naphazoline]* Schazoo, Pakistan
**Gemini [+ Tetryzoline]* Al Pharm, Afrika Kidul
**Oculerge [+ Tetryzoline] Pharmacare*, Afrika Kidul
**Opsil-A [+ Tetryzoline] Allergan*, Thailand
**Spersallerg [+ Tetryzoline]* Grup Actavis, Malta; Al Pharm, Afrika Kidul; Laboratorium. Thea, Rumania; The Laboratoires Thea, Polandia; Laboratoires Thea, Slovakia; Laboratorium Thea, Republik Céko; Novartis, Ekuador; Novartis, Hong Kong; Novartis, Taiwan; Novartis Pharma, Bulgaria; Novartis Pharmaceuticals, Kuwait; THEA, Suis; THEA, Norwégia
**Spersallerg 0.5 mg/ml+0.4 mg/ml* [+ Tetryzoline] THEA, Hungaria
**Analergin [+ Naphazoline]* Ivax, Lituania
**Phenazolinum Polfa Warszawa*, Polandia
**Sanorin Combi [+ Naphazoline] Xantis*, Slovakia
**Albalon A [+ Naphazoline] Allergan*, Kénya; Allergan, Selandia Anyar; *Allergan*, Tanzania
**Albalon-A [+ Naphazoline] Allergan*, Australia; Allergan, Kuwait
**Albasol-A [+ Naphazoline] Allergan*, Ekuador
**Alergiftalmina [+ Naphazoline]* Davi, Portugal
**Alergoftal [+ Naphazoline] Alcon*, Kuwait; M4, Spanyol
**Allergoconjunct [+ Tetryzoline] Infectopharm*, Jérman
**Allergopos N [+ Tetryzoline] Ursapharm*, Malta
**Citol A + T [+ Tetryzoline] Oftalmica*, Paraguay
**Midazol Ofteno [+ Naphazoline]* Sophia, Méksiko
**Oftalirio [+ Naphazoline]* Saval, Paraguay
**Refresh Eye Allergy Relief [+ Naphazoline] Allergan*, Kanada
**Rinobanedif [+ Bacitracin, + Neomycin, + Xylometazoline]* Laboratorio Bago, Cilé
**Zincfrin-A [+ Naphazoline, + Zinc Sulfate] Alcon*, Kuwait
**Allertec Ukaszenia [+ Naphazoline] Polfa Warszawa*, Polandia
**Antistina-Privin [+ Naphazoline] Thea Nordic*, Dénmark
**Antistine-Privine [+ Naphazoline] Novartis Pharmaceuticals,* Kuwait
**Murine Allergy [+ Xylometazoline]* Abbott, Kuwait
**Noscam [+ Naphazoline]* Riyadh Pharma, Oman
**Ocured [+ Naphazoline]* Riyadh Pharma, Oman
**Oftalirio [+ Naphazoline] Nicolich*, Chili
**Oftophenazol [+ Naphazoline]* Polfa Warszawa, Polandia
**Ophtazolin [+ Naphazoline]* Dar Al Dawa, Oman
**Otrivine-Antistin [+ Xylometazoline]* Thea Pharmaceuticals, Inggris
**Rhinophenazol [+ Naphazolin]* Polfa Warszawa, Polandia

## Éfék samping 
Éfék samping mangrupa hiji éfék nu teu dipikahayang tina pamakéan hiji ubar. Éfék samping bisa béda unggal jalma, gumantung kana kaayaan panyakit, yuswa, beurat awak, jinis kelamin, étnis, atawa kaayaan kaséhatan hiji jalma. Ieu di handap sababaraha éfék samping bisa kaalaman sanggeus pamakéan antazoline diantarana:

* Réaksi hipersensitif
* Iritasi, rarasaan kaduruk atawa kaseureud (bisa leungit sababaraha menit sanggeus pamakéan ubar keclak panon) 
* Sensitifitas kana kulit
* Ulah dipaké kana kulit nu rusak atawa kaayaan kulit éksim
* Hipertensi (Salila pamakéan sakurang-kurangna 14 poé)

## Rujukan