町田武生

**町田 武生**（まちだ たけお、1943年 - ）は、日本の生命科学の研究者。埼玉大学名誉教授。

## 専門分野
*神経科学：間脳視交叉上核、扁桃核、海馬歯状回
*実験老年学：集団の老化、社会的優劣の加齢・老化
*動物生命科学：成長遅延モデル、情動、行動内分泌

## 学歴
東京都出身。千代田区立練成中学校、東京都立日比谷高等学校を経て、1967年、東京大学理学部生物学科卒業。1969年3月、東京大学大学院理学系研究科動物学専攻修士課程修了。

1972年3月、東京大学大学院理学系研究科動物学専攻博士課程修了。理学博士（東京大学）。

## 職歴
1972年4月、東京都立老人総合研究所（現・東京都健康長寿医療センター）生物学部研究員（-1978年9月）。

1978年、鹿児島大学理学部生物学科助教授（-1982年3月）。1982年、 広島大学理学部生物学科助教授（-1988年9月）。

1988年、埼玉大学理学部生体制御学科助教授（-1990年4月）。1990年、埼玉大学理学部生体制御学科教授（-2006年3月）。

2006年4月、埼玉大学理学部長（-2008年3月）。2006年4月、埼玉大学大学院理工学研究科生体制御学専攻教授（-2009年3月）。2008年4月、埼玉大学副学長（-2009年3月）。

2009年4月、埼玉大学学長特別補佐（-2010年3月）。2009年4月、埼玉大学大学院理工学研究科名誉教授。

## 論文
*Delayed Postnatal Growth and Anterior Pituitary Development in Growth-retarded (grt) Female Mice.  K. Kobayashi, K.Yamamoto, S.Kikuyama, Y.Tanaami, T.Machida, T.Kobayashi , Zoological Science 38 238-246 2021.6.1
*Possible involvement of thyrotropin-releasing hormone receptor 3 in the release of prolactin in the metamorphosing bullfrog larvae.Masaki Nakano, Itaru Hasunuma, Atsuko Minagawa, Shawichi Iwamuro, Kazutoshi Yamamoto, Sakae Kikuyama, Takeo Machida, Tetsuya Kobayashi , General and comparative endocrinology , 267 36-44 2018.10.1
*Contribution of Nucleus Accumbens Core (AcbC) to Behavior Control during a Learned Resting Period: Introduction of a Novel Task and Lesion Experiments. Chika Sato, Masato Hoshino, Naori Ikumi, Kentarou Oba, Akiko Koike, Osamu Shouno, Tatsuhiko Sekiguchi, Tetsuya Kobayashi, Takeo Machida, Gen Matsumoto, Hiroyuki Furudate, Tetsuya Kimura , PLOS ONE 9(4) 1-13 2014.4
*Phosphatidylglucoside: a novel marker for adult neural stem cells. Jun Kaneko, Masami O Kinoshita, Takeo Machida, Yoko Shinoda, Yasuko Nagatsuka, Yoshio Hirabayashi , Journal of neurochemistry 116(5) 840-4 2011.3
* Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain. Jung Hoon Yang, Akira Wada, Kazuyuki Yoshida, Yurika Miyoshi, Tomoko Sayano, Kayoko Esaki, Masami O Kinoshita, Shozo Tomonaga, Norihiro Azuma, Masahiko Watanabe, Kenji Hamase, Kiyoshi Zaitsu, Takeo Machida, Albee Messing, Shigeyoshi Itohara, Yoshio Hirabayashi, Shigeki Furuya , The Journal of biological chemistry 285(53) 41380-90 2010.12.31
*D2 Dopamine receptor subtype mediates the inhibitory effect of dopamine on TRH-induced prolactin release from the bullfrog pituitary. Masaki Nakano, Atsuko Minagawa, Itaru Hasunuma, Reiko Okada, Marie-Christine Tonon, Hubert Vaudry, Kazutoshi Yamamoto, Sakae Kikuyama, Takeo Machida, Tetsuya Kobayashi , GENERAL AND COMPARATIVE ENDOCRINOLOGY 168(2) 287-292 2010.9
*Relationship between growth retardation and impaired glucose tolerance in hypothyroidal growth-retarded (grt) mice. Yoshie Tasaki, Yusuke Taguchi, Takeo Machida, Tetsuya Kobayashi , CONGENITAL ANOMALIES 50(3) 186-192 2010.9
* Molecular cloning of bullfrog D2 dopamine receptor cDNA: Tissue distribution of three isoforms of D2 dopamine receptor mRNA. Masaki Nakano, Itaru Hasunuma, Reiko Okada, Kazutoshi Yamamoto, Sakae Kikuyama, Takeo Machida, Tetsuya Kobayashi , GENERAL AND COMPARATIVE ENDOCRINOLOGY 168(1) 143-148 2010.8
* Impaired insulin secretion from the pancreatic islets of hypothyroidal growth-retarded mice. Yusuke Taguchi, Yoshie Tasaki, Kiyoshi Terakado, Kenichi Kobayashi, Takeo Machida, Tetsuya Kobayashi , JOURNAL OF ENDOCRINOLOGY 206(2) 195-204 2010.8
*Lipid rafts enriched in phosphatidylglucoside direct astroglial differentiation by regulating tyrosine kinase activity of epidermal growth factor receptors. Masami O. Kinoshita, Shigeki Furuya, Shinya Ito, Yoko Shinoda, Yasuhiro Yamazaki, Peter Greimel, Yukishige Ito, Tsutomu Hashikawa, Takeo Machida, Yasuko Nagatsuka, Yoshio Hirabayashi , BIOCHEMICAL JOURNAL 419(3) 565-575 2009.5
*Sympathetic neural regulation of olfactory bulb blood flow in adult and aged rats. Kanako Shiba, Takeo Machida, Sae Uchida, Harumi Hotta , AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL 147(1-2) 75-79 2009.5
*Selective upregulation of 3-phosphoglycerate dehydrogenase (Phgdh) expression in adult subventricular zone neurogenic niche. Masami O. Kinoshita, Yoko Shinoda, Kazuhisa Sakai, Tsutomu Hashikawa, Masahiko Watanabe, Takeo Machida, Yoshio Hirabayashi, Shigeki Furuya , NEUROSCIENCE LETTERS 453(1) 21-26 2009.3
*Effect of Corticosterone on Developing Hippocampus: Short-Term and Long-Term Outcomes. Wen-Bin He, Ming Zhao, Takeo Machida, Nai-Hong Chen , HIPPOCAMPUS 19(4) 338-349 2009
*Demonstration of the Proopiomelanocortin Signaling System in the Primary Immune Organ of the Quail. Tetsuya Kobayashi, Aya Takaso, Shigeyasu Tanaka, Masafumi Amano, Akiyoshi Takahashi, Shawichi Iwamuro, Takeo Machida , TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY 1163 441-443 2009
*Impaired Development of Somatotropes, Lactotropes and Thyrotropes in Growth-Retarded (grt) Mice. Kenichi Kobayashi, Kazutoshi Yamamoto, Sakae Kikuyama, Takeo Machida, Tetsuya Kobayashi , JOURNAL OF TOXICOLOGIC PATHOLOGY 22(3) 187-194 2009
*Effects of glucocorticoids on age-related impairments of hippocampal structure and function in mice. Wen-Bin He, Jun-Long Zhang, Jin-Feng Hu, Yun Zhang, Takeo Machida, Nai-Hong Chen , Cellular and molecular neurobiology 28(2) 277-91 2008.2
*Thyroid hormone and adult neurogenesis. Katsuya Uchida, Tetsuya Kobayashi and Takeo Machida , Neurogenesis Research Advances ed. by M.P.Klausen 127-140 2008
*Effects of nicotine on regional blood flow in the olfactory bulb in rats. Kanako Shiba, Takeo Machida, Sae Uchida, Harumi Hotta , European journal of pharmacology 546(1-3) 148-51 2006.9.28
*Topographic analysis of cell proliferation in the hippocampus of the adult mouse. Katsuya Uchida, Souichiro Nakamura, Tetsuya Kobayashi, Takeo Machida , Neuroreport 16(18) 2033-6 2005.12.19
*Thyroid-stimulating hormone receptor levels and binding affinity in the thyroid gland of growth-retarded mice. Kenichi Kobayashi, Mirei Sato, Takeo Machida, Tetsuya Kobayashi , Congenital anomalies 45(3) 89-92 2005.9
*Citrullination preferentially proceeds in glomerular Bowman's capsule and increases in obstructive nephropathy. Dongyun Feng, Toshiyuki Imasawa, Tadasuke Nagano, Masaru Kikkawa, Kaori Takayanagi, Takako Ohsawa, Kyoichi Akiyama, Akihito Ishigami, Tosifusa Toda, Tetsuya Mitarai, Takeo Machida, Naoki Maruyama , Kidney international 68(1) 84-95 2005.7
*Impaired neurogenesis in the growth-retarded mouse is reversed by T3 treatment. Katsuya Uchida, Masako Yonezawa, Souichiro Nakamura, Tetsuya Kobayashi, Takeo Machida , Neuroreport 16(2) 103-6 2005.2.8
*Synthesis and Release of Steroids in Intestines form Cynomolgus Monkeys (Macaca fascicularis). Miyamoto Sachiko, Chen Yang, Nakamura Shin'ichiro, SANKAI Tadashi, MACHIDA Takeo, YOSHIDA Takashi , Zoological science 21(6) 639-648 2004.6.25
*Senescence marker protein-30 as a novel antiaging molecule. Dongyun Feng, Yoshitaka Kondo, Akihito Ishigami, Masashi Kuramoto, Takeo Machida, Naoki Maruyama , Annals of the New York Academy of Sciences 1019 360-4 2004.6
*Association between bone loss and promoter polymorphism in the IL-6 gene in elderly Japanese women with hip fracture. Dongyun Feng, Hideaki Ishibashi, Seizo Yamamoto, Takayuki Hosoi, Hajime Orimo, Takeo Machida, Yasuko Koshihara , Journal of bone and mineral metabolism 21(4) 225-8 2003
*Stimulatory effects of prostaglandin E2 on neurogenesis in the dentate gyrus of the adult rat. Katsuya Uchida, Kentarou Kumihashi, Satoshi Kurosawa, Tetsuya Kobayashi, Keiichi Itoi, Takeo Machida , Zoological science 19(11) 1211-6 2002.11
*Monitoring the Reproductive Status of Female Gorillas (Gorilla gorilla gorilla) by Measuring the Steroid Hormones in Fecal Samples.Miyamoto Sachiko, Chen Yang, Kurotori Hidetoshi, SANKAI TADASHI, YOSHIDA TAKASHI, MACHIDA TAKEO , Primates : journal of primatology 42(4) 291-299 2001.10.1
*Responses of the Thyroid Gland to TSH and Other Thyroid Stimulators in the Growth-Retarded (grt) Mouse. Kobayashi Kenichi, Yamamoto Hideaki, Kobayashi Tetsuya, MACHIDA Takeo , Zoological science 18(7) 955-691 2001.9.20
*Neural recognition molecule NB-2 of the contactin/F3 subgroup in rat: Specificity in neurite outgrowth-promoting activity and restricted expression in the brain regions. Junko Ogawa, Suni Lee, Kouichi Itoh, Saburo Nagata, Takeo Machida, Yasuo Takeda, Kazutada Watanabe , Journal of Neuroscience Research 65(2) 100-110 2001.7.15
*Thyroid function of growth-retarded mice. K.Kobayashi, M.Sato, T.Kobayashi and T.Machida , Perspective in Comparative Endocrinology: Unity and Diversity ed. by H.J.Th.Goos et al. 385-390 2001.5
*Acetylsalicylic acid reduces ischemia-induced proliferation of dentate cells in gerbils. K Kumihashi, K Uchida, H Miyazaki, U Kobayashi, T Tsushima, T Machida , NEUROREPORT 12(5) 915-917 2001.4
*Melatonin synthesis in the quail bursa of Fabricius. T Kobayashi, M Tada, MT Itoh, Y Sumi, T Machida , PERSPECTIVE IN COMPARATIVE ENDOCRINOLOGY: UNITY AND DIVERSITY 377-382 2001
*A cystatin-related gene, testatin/cresp, shows male-specific expression in germ and somatic cells from the initial stage of murine gonadal sex-differentiation. Y Kanno, M Tamura, S Chuma, T Sakurai, T Machida, N Nakatsuji , INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 43(8) 777-784 1999.11
*Hypophysio-thyroidal axis in growth-retarded mice. K Kobayashi, T Kobayashi, K Yamamoto, S Kikuyama, T Yoshida, T Machida , ADVANCES IN COMPARATIVE ENDOCRINOLOGY, TOMES 1 AND 2 1101-1105 1997
*Effects of Unilateral and Bilateral Orchidectomy on Laterality of Neurons of the Preoptic Area and Plasma Levels of Gonadotropins and Testosterone in Male Mice. Nakazawa Toshiyuki S., Machida Takeo, Kawashima Seiichiro , Zoological Science 9(2) p357-363 1992.4
*Age-related changes in distribution of cytochrome P-450 in the hepatic lobule of the rat. Takeo Machida, Masaya Miyatake, C. F A van Bezooijen , Archives of Gerontology and Geriatrics 11(1) 43-52 1990
*Long-lasting effects of orchiectomy and its preceding procedures on open field behavior in male mice. Machida Takeo, Iso Shiho, Nomura Tetsuo , Zoological Science 4(1) p151-158 1987.2
*Influence of environmental salinity on the development of chloride cells of freshwater and brackish-water medaka,Oryzias latipes.Miyamoto Taisuke, Machida Takeo, Kawashima Seiichiro , Zoological Science 3(5) p859-865 1986.10
*Effects of Food Deprivation, Restaint and Cold Exposure on Gastric Ulcer Formation in the Mouse. Takeo Machida and Shiro Shigeyama,Journal of Science of the Hiroshima University Ser.B Div.1 32 15-23 1985.12
*Accumulation of ceroid and lipofuscin with age in the adrenal gland of normal and chronically stressed male mice. MACHIDA T.  J Sci Hiroshima Univ Ser B Div 1 32 129-141 1985.12
*Effects of Different Sizes of Postweaning Grouping on Open Field Behavior in Male Mice. Takeo Machida, Satoru Kobayashi and Tetsuo Noumura , Journal of Sciemce of the Hiroshima University Ser.B Div.1 31 155-162 1983.12
*Age-associated changes in plasma testosterone levels in male mice and their relation to social dominance or subordinance. Takeo Machida, Yumiko Yonezawa, Tetsuo Noumura , Hormones and Behavior 15(3) 238-245 1981.9
*Effects of Amygdaloid Lesions upon Luteinization of Ovaries in Rats Showing Spontaneous Vaginal Estrus. Takeo Machida , Reports of the Faculty of Science Kagoshima University (Earth Sci. & Biol) 13 121-126 1980.12
*Luteinization of ovaries under stressful conditions in persistent-estrous rats bearing hypothalamic lesions. Takeo Machida, Endocrinologia Japonica 18(5) 427-431 1971
*Luteinization of ovarian transplants in gonadectomized male and female rats under stressful conditions and its relation to sexual differentiation of the hypothalamus. Takeo Machida, Endocrinologia Japonica 17(3)189-193 1970

## 著書
### 共著
*『新老年学』折茂肇（編集）（分担執筆）、東京大学出版会、1992年
*『生物の実験 基礎と応用』竹内正幸・石原勝敏（編集）（分担執筆）、裳華房、1992年
*『動物解剖図』日本動物学会（分担執筆）、丸善、1990年
*『新医科学大系4B発生と老化』江口吾朗・大澤仲昭（編）（分担執筆）、中山書店、1985年
*『平凡社大百科事典』（分担執筆）、平凡社、1984年
*『臨床老年医学大系 1 基礎老年医学総論』村上元孝他（編）（分担執筆）、情報開発研究所、1983年
*『動植物の解剖』宇津木和夫他（編）（分担執筆）、培風館、1982年
*『老化制御』吉川正己他（編）（分担執筆）、朝倉書店、1977年

## 受章
*2022年4月　春の叙勲で瑞宝中綬章受章

## 脚注