Ọrịa a na-amaghị ihe kpatara ya

Villitis nke anamaghi nke enwere Ike ikpo chronic villitis, but mmeru ahu nke placenta. VUE bu onodu inflammation nke gunyere chronic villi(placenta villi). 

VUE bu onodu na puta kari ihe nke but Intrauterine growth restriction (IUGR). IUGR gunyere mgbe NWA e bu na afo anaghi eto ohuma, NWA inwu na afo, NWA ipu na afo na imu NWA mgbe oge n'erubeghi.

VUE bụ mmerụ ahụ a na-ahụkarị nke a na-akọwa site na ọzịza na placental chorionic villi. A na-egosikwa VUE site na mbufe nke lymphocytes nne gafee Placenta.

A na-achọpụta VUE na placentas 7-10% na ime ime. Ihe dị ka 80% nke ndị na-arịa ọrịa VUE nọ na placentas (ihe karịrị izu 37 nke ime). A ga-enyocha onye na-arịa ọrịa VUE n'ime placenta na-erughị izu 32 maka ọrịa villitis na-efe efe.

## Mmalite nke ọrịa
Mkpụrụ ndụ na-afụ ụfụ nke sitere n'aka nne nwere ike ịnweta stoma villous foetal n'ọtụtụ ụzọ:

Enwere ike imebi ihe mgbochi trophoblast. N'ime ọnwa atọ nke atọ, eriri syncytial (ìgwè nucleated nke e guzobere na syncytiotrophoblast) na-agbaji  ma na-agbapụ site na placental villi. Ihe na-agbapụta nwere ike iwepụ stroma villous. Ihe mgbochi ahụ nwere ike imebi ma ọ bụ site na thrombosis foetal ma ọ bụ mmebi ischemic site na ọrịa obi nne. Necrosis nke syncytiotrophoblasts efere ike ibilite n'ihi ịrụ ọrụ nke ihe ndị na-eme ka ọbara kpụkọọ, usoro mgbakwunye ma ọ bụ platelets site na antibodies ma ọ bụ antiphospholipids.

Enwere ike ime syncytiotrophoblasts iji gosipụta mkpụrụ ndụ na-arapara n'ahụ (intracellular adhesion molecule 1, E-selectin) na VUE, ọ bụ ezie na n'ọnọdụ nkịtị anaghị egosipụta mkpụrụ ndụ na'arapara n"ahụ.

Mkpụrụ ndụ lymphocytes nke nne nwere ike ịbanye na stroma nwa ọhụrụ site na ịgafe ihe mgbochi trophoblastic villous site na villi na-ejikọta. Villi na-ejikọta ya na-efunahụ okpokoro epithelial syncytiotrophoblast na-aga n'ihu ka villi na-etolite n'ime trophoblasts na-awakpo site na usoro mmepe nke placenta. Ihe na-egbu egbu, IL-15, maka CD8+ memory T-cell na-egosipụta site na decidual stromal cells. Ahịa nke lymphocytes nne na-emeghachi omume na antigen na deciduitis na-adịghị ala ala nwere ike ịmalite ma banye site na decidua.

VUE is a T-cell mediated, CD8+ dominating inflammatory reaction. VUE develops in the foetal fibrovasculature stroma of the placenta villi usually towards the end of pregnancy (term placentas).
The lymphocytes in VUE are of maternal origin. VUE is a host-derived inflammatory response happening within a donor allograft tissue. The non-T-cell component of the inflammatory infiltrate originates both from the maternal and placental side. Majority of the antigen-presenting cells were Hofbauer cells (macrophages) were of foetal origin. Perivillous monocyte-macrophages and histiocytic giant cells were of maternal origin.
Foetal macrophages in VUE proliferate and are activated as a result of the up-regulation of MHC class 2 antigen expression.
Examination of a male placenta with VUE demonstrated that 11.2% of the intravillous CD3+ lymphocytes were foetal, and 88.8% were maternal. Macrophages, intervillous lymphocytes, multinucleated giant cells were maternal; 10.5% of intravillous CD68+ cells and 96.4% of perivillous CD68+ cells were maternal. Lymphocytes were predominantly maternal T-cells. Maternal cells can enter the placental villi and the foetus as well.

## Nnyocha
VUE nwere ike ịbụ ụdị abụọ, obere villitis na-adịghị ala ma ọ bụ villitis na'elu.Obere ogo villitis na-adịghị ala na-agụnye ihe na-erughị 10 villi nwere lymphocytes. Obere ogo villitis na-adịghị ala nwere ike ịbụ ma ọ bụ focal ma ọ bụ multifocal. Focal etinyela villi na naanị otu slide iko, ebe multifocal etinyela villii na ọ dịkarịa ala slides abụọ. Ọrịa villitis na-adịghị ala ala nwere ihe karịrị 10 na-afụ ụfụ kwa anya. A na-ekewa villitis na-adịghị ala ala dị elu n'ime diffuse na patchy. A na-eji okwu patchy eme ihe ma ọ bụrụ na ihe na-erughị 30% nke villi distal metụtara. A na-eji okwu diffuse eme ihe ma ọ bụrụ na ihe karịrị 30% nke villi distal metụtara.   &#x5B;**'&#x5D;</sup>

VUE nwere usoro abụọ dị iche iche. Ihe dị ka 50% nke ikpe ndị ahụ na-emetụta naanị villi dịpụrụ adịpụ (villi dị n'etiti na nke ikpeazụ) ma ọ naghị agụnye villi dị nso, villi na-ejikọta na plati basal, na plati chorionic. Usoro nke abụọ a na-ahụkarị (ihe dị ka 30% nke ikpe VUE) na-agụnye proximal stem villi (na ikekwe chorionic plate) na distal villi na-abụkarị. Ụdị VUE a nwere njikọ na mmerụ ahụ obtrusive vascular obtrusive (Obliterative Foetal Vasculopathy).

VUE enweghị ihe ịrịba ama na mgbaàmà ndị a kapịrị ọnụ na-atụ aro nchọpụta; mana nyocha nke filtrate inflammatory nwere ike inye aka na nchọpụta.Ihe mejupụtara inflammatory infiltrate na VUE na ọkwa mkpụrụ ndụ bụ macrophages na lymphocytes. Ọnụ ọgụgụ nke mkpụrụ ndụ dịgasị iche site na ikpe. lymphocytes ndị dị na VUE bụ CD8+ T-cell mgbe ahụ CD4. A na-enwekarị oke nke 0.1 na 0.5 maka CD4/CD8. Macrophages ndị dị ebe ahụ bụ Mac387-, CD68 na HAM56+ sochiri. Class 2 isi histocompatibility complex (MHC) antigens na macrophages na-achịkwa na saịtị VUE. Neutrophils ekwesịghị ịnọ na saịtị VUE. VUE bụ ọnọdụ na-emetụta ọzịza ọ bụghị ibute ọrịa. Ọnụ ọgụgụ dị elu nke neutrophils dị na villitis na-efe efe ọ bụghị VUE.[1]

=== Ọrịa Ọrịa Na-egbu Ọrịa ===
N'ụzọ Histomorphologically, a na-akọwa VUE site na infiltrate lymphocytic nke chorionic villi na-enweghị ihe ngosi. Plasma cells kwesịrị ịghara ịdị; ọnụnọ nke plasma cells na-egosi na ọ na-ebute ọrịa, dịka CMV.   <sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">&#x5B;**'&#x5D;
Usòrò:Villitis_of_unknown_etiology_-_intermed_mag.jpg|alt=Intermed. mag.|N'etiti. mag.
Usòrò:Villitis_of_unknown_etiology_-_high_mag.jpg|alt=High mag.|Nnukwu ihe.


### Nnyocha dị iche iche
A na-ejikarị VUE eme ihe na villitis na-efe efe. Enwere ike ịmata ha site na njirimara ndị a: Enweghị ihe ịrịba ama nke ibute ọrịa na nne ma ọ bụ nwa ọhụrụ nwere VUE. Villi na-efe efe nwere ma ọrịa nne na nwa e bu n'afọ. VUE bụ ihe a na-ahụkarị karịa ọrịa villitis na-efe efe; ọrịa villitis nwere ọrịa dị na ihe dịka 1-4 ọmụmụ kwa 1000 ọmụmụ. VUE dị na ihe dịka ọmụmụ 76-136 kwa ọmụmụ 1000. VUE na-eme na okwu placenta, na ngwụcha ọnwa atọ nke atọ ime. Ọrịa na-efe efe na-eme na mbido nke atọ ruo nke abụọ nke afọ ime. Mmetụta na-efe efe na-agụnye akụkụ ka ukwuu nke placenta (ụdọ umbilical, plate chorionic, membrane) ma e jiri ya tụnyere VUE (terminal na stem villi). N'ihe gbasara akụkọ ihe mere eme, a na-akọwa VUE na lymphocytes karịa villitis na-efe efe. Nlaghachi nke ọrịa villitis na-efe efe bụ ihe a na-adịghị ahụkebe. VUE nwere 10% ruo 15% ugboro ugboro.

## Mgbochi
*Amata beghi mgbochi Oria nke VUE, mana ana ekwu n'obu Oria malitere na Treponema pallidum, Toxoplasma gondi, and cytomegalovirus* .

## Ọrịa na-efe efe
Na New Zealand VUE putara ihe na Caucasians Karia na Maori nakwa Asian. Obu umunwaanyi buru ibu na enweta Oria VUE;  nke enwere Ike i malite Maka placenta di ukwu, ya bu nwanyi e nwe villous macrophages nke ukwu  ga eme ka antigen putara nu di ukwu nkea bia Mee ka onye ahu new Oria VUE .
Òtù:Pages with unreviewed translations