Elizabeth Nabel

**Elizabeth Nabel** likitan zuciya ce na Amurka kuma Mataimakiyar Shugaban Kasuwanci a ModeX Therapeutics da OPKO Health . Kafin wannan rawar, ta yi aiki a matsayin Shugabar Lafiya ta Brigham da Asibitin Mata na Brigham, Farfesa na Kiwon Lafiya a Makarantar Kiwon Lafiyar Harvard, da Darakta na Cibiyar Nazarin Zuciya, Lung, da Jinin ta NIH.

## Rayuwa ta farko da ilimi
An haifi Nabel Elizabeth Emilee Guenthner kuma ta girma a St. Paul, Minnesota . Nabel ya zama mai sha'awar ilimin kimiyyar halittu yayin binciken kimiyya a Kwalejin St. Olaf . Ta kammala karatun summa cum laude daga St. Olaf a 1974 kuma ta sami digiri na MD daga Kwalejin Kiwon Lafiya ta Weill Cornell a 1981.  A matsayinta na babban dalibi na likita, ta yi aiki na wata daya a fannin ilimin zuciya a asibitin Brigham da mata. 

Daga baya ta koma Brigham da Asibitin Mata don horar da ma'aikatan gidanta a cikin magani na ciki, tana sha'awar haɗa likitancin asibiti tare da bincike. Ta yi la'akari da ilimin zuciya mafi kyawun wasa a gare ta saboda ta yi la'awar mafi kyawun ƙwarewa don samun ci gaba a matsayin likita-masanin kimiyya.

## Ayyuka
A shekara ta 1987, bayan kammala karatunsu a Boston, Elizabeth Nabel da mijinta Gary Nabel sun koma Jami'ar Michigan, inda Elizabeth Nabel ta hau ta hanyar matsayi na ilimi zuwa Farfesa na Medicine da Physiology da Darakta na sabon Cibiyar Binciken Cardiovascular kuma ta zama Babban Sashen Cardiology. Nabel ya koma Cibiyar Lafiya ta Kasa (NIH) a cikin 1999 don zama Darakta na Kimiyya na Binciken Asibiti da Babban Sashen Biology na Vascular a cikin shirin intramural na Cibiyar Zuciya, Lung da Jini ta Kasa (NHLBI). A matsayinsa na darektan Cibiyar Nazarin Zuciya, Lung, da Jini ta NIH daga 2005 zuwa 2009, Nabel tana da tarihin bayar da shawarwari da fadada damar samun kulawa. Ta yi amfani da fayil ɗin bincike na dala biliyan 3 don kafa shirye-shiryen kimiyya na farko a cikin genomics, ƙwayoyin halitta, da bincike na fassara. A lokacin da take aiki, NHLBI ita ce cibiyar NIH ta farko da ta hanzarta bita don sabbin aikace-aikacen tallafin bincike na bincike. Ta kasance co-kafa kungiyar Global Alliance for Chronic Diseases . Ɗaya daga cikin ƙoƙarin sa hannu ita ce kamfen ɗin Red Dress Heart Truth, wanda aka tsara don wayar da kan jama'a game da zuciya tsakanin mata ta hanyar haɗin gwiwar masana'antu.

A shekara ta 2010, Nabel ta koma Brigham da Asibitin Mata a matsayin shugaban kasa da Farfesa na Kiwon Lafiya a Makarantar Kiwon Lafiyar Harvard. A Brigham Health, Nabel ya jagoranci canjin ƙungiya da aka mayar da hankali kan kirkire-kirkire da gina al'adun haɗin gwiwa don sake fasalin isar da kiwon lafiya, kulawa mai tausayi, binciken kimiyya, da horar da ƙarni na gaba na shugabannin likita da kimiyya. Ta mayar da hankali kan fadada duniya na Brigham Health, bincike kasuwanci da kuma taimakon jama'a, bayan da ta tara fiye da dala biliyan 1.75. A cikin 2021, Nabel ta shiga ModeX Therapeutics, kamfani da ta kafa tare da Dokta Gary Nabel da Elias Zerhouni wanda ya mai da hankali kan maganin rigakafi don cutar kansa da cututtukan cututtuka.

### Binciken kiwon lafiya
Ayyukan Nabel a kan kwayoyin halitta na cututtukan zuciya sun samar da takardun shaida 17 da fiye da wallafe-wallafen kimiyya 250. Gudummawar kimiyya ta Nabel a cikin canja wurin kwayar halitta ta zuciya sun haɓaka dabarun kwayoyin halitta da na salula,  ya bayyana ilimin lissafi na atherosclerosis,  kuma ya bayyana hanyoyin rarraba sel da ci gaban ƙwayoyin tsoka masu laushi a cikin jijiyoyin jini. 

Nazarin Nabel game da cutar Hutchinson-Gilford progeria ya nuna lalacewar ƙwayar ƙwayar ƙwaƙwalwar ƙwayar cuta da ke haifar da ciwon zuciya da bugun jini. Ta gudanar da nazarin asibiti don fahimtar gudummawar abubuwan kwayar halitta ga cututtukan da ke yaduwa da kumburi a cikin jijiyoyin jini, gami da cututtukani na yau da kullun kamar atherosclerosis da rare, tsufa da wuri a cikin Hutchinson Gilford progeria syndrome.  A watan Nuwamba 2020, Hukumar Abinci da Magunguna ta Amurka ta amince da lonafarnib, wanda ke taimakawa wajen hana gina progerin mara kyau da irin waɗannan sunadarai. Wani gwaji na asibiti a cikin 2018 ya nuna raguwar yawan mace-mace ~ magani tare da lonafarnib kadai idan aka kwatanta da babu magani (3.7% vs. 33.3%) ~ a matsakaicin lokacin bin bayan gwaji na shekaru 2.2.

A dakin gwaje-gwaje na NHLBI, Nabel ta bayyana hanyoyin da zagaye na tantanin halitta da sunadarai na ci gaba ke sarrafa yaduwar Kwayoyin jijiyoyi a cikin jijiyoyin jini, tsari mai mahimmanci don ci gaban atherosclerosis da Restenosis. Gidan gwaje-gwaje na ilmin halitta na jijiyoyin jini ya nuna rawar da masu hana sake zagayowar sel ke takawa a kan yaduwar jijiyoyi da kumburi, kuma wannan binciken ya buɗe sabbin hanyoyin don manufofi na warkewa a cikin jijiyoyin jini. Nabel ya ba da gudummawa ga manufofi da bincike na asali game da kwayoyin halitta.

### Kungiyar Kwallon Kafa ta Kasa
Gina kan jajircewarta na rayuwa don inganta kiwon lafiya ta hanyar kimiyya, a cikin 2015 an nada Nabel a matsayin babban mai ba da shawara kan kiwon lafiya da kiwon lafiya ga Kungiyar Kwallon Kafa ta Kasa. A cikin wannan sabon rawar mai ba da shawara, Nabel ya ba da dabarun dabarun ga kokarin kiwon lafiya, kiwon lafiya da kimiyya na NFL; ya shiga a matsayin memba na ex-officio a kowane kwamiti mai ba da shawarwari na kiwon lafiya na NFL; kuma ya gano wuraren da NFL ta inganta lafiyar mai kunnawa, kulawa da magani. Nabel ta sauka daga wannan rawar a shekarar 2017 bayan ta jagoranci NFL don hayar Babban Jami'in Kiwon Lafiya na farko.

## Kwamitin
Nabel tana aiki a kan allon Medtronic,  Moderna,  Lyell,  Accolade,  Lasker Foundation,  da Kudancin Florida PBS.

Nabel ya yi aiki a kan allon edita na mujallu goma sha takwas, gami da New England Journal of Medicine, Science, Journal of Clinical Investigation, Science Translational Medicine, da Circulation.

Nabel ya yi aiki a Kwamitin Ba da Shawara na Kimiyya na Moderna a lokacin da aka kafa shi a cikin 2010 kuma daga baya ya shiga Kwamitin Daraktoci a cikin 2015. Ta taimaka wajen jagorantar kamfanin ta hanyar matakan da aka tsara kuma ta sauƙaƙe ci gaban fasaharta, gami da ƙarni na Moderna na allurar rigakafin COVID. A watan Agustan 2020, ta sauka na ɗan lokaci daga Kwamitin Moderna "daga yawan taka tsantsan don kauce wa duk wani yiwuwar rikice-rikicen sha'awa a bangarenta ko bangaren Moderna" saboda Brigham da Asibitin Mata suna shiga a matsayin ɗaya daga cikin wuraren gwaji 89 na rigakafin Moderna COVID. The Boston Globe's Spotlight ya nuna damuwa game da shugabannin asibitin Boston, gami da Nabel, suna aiki a kan allon jama'a,  amma waɗannan damuwa ba su taɓa zama da muhimmanci ba kuma Brigham da Asibitin Mata "sun kare kasancewar Nabel a cikin allon, suna cewa ba su taka rawar gani ba wajen zabar Brigham a matsayin wurin gwaji. "

A watan Maris na 2021, lokacin da Nabel ta sauka daga Brigham da Asibitin Mata  ta shiga Dokta Gary Nabel da Elias Zerhouni a kamfanin biotechnology da suka kafa, ModeX Therapeutics.  

Ta koma Kwamitin Daraktocin Moderna a watan Maris na shekara ta 2021.

### Kyaututtuka
Nabel an kira shi daya daga cikin manyan shugabannin kasar a fannin kiwon lafiya ta Modern Healthcare  da Becker's Hospital Review,  kuma daya daga cikin mutane 50 mafi iko a Boston ta Boston Magazine.  Darajarta ta haɗa da Kyautar Bostonian mai daraja daga Babban Kamfanin Kasuwanci na Boston,  lambar yabo ta Kober daga Ƙungiyar Likitocin Amurka,  Kyautar Champion a Kula da Lafiya daga Boston Business Journal,  da Kyautar Rambam daga Rambam Health Care Campus a Isra'ila. Ita memba ce ta Kwalejin Fasaha da Kimiyya ta Amurka, Kwalejin Kiwon Lafiya ta Kasa, Ƙungiyar Likitocin Amurka, Ƙungiyar Amurka don Binciken Asibiti, kuma ita memba ce ta Ƙungiyar Amurka ta Ci gaban Kimiyya.

### Lafiya da kiwon lafiya na duniya
Nabel ta shiga hadin gwiwa wajen karfafa tsarin isar da kiwon lafiya a Rwanda, Haiti da China. Taimakawa [Abokan hulɗa a Lafiya], Nabel ya taimaka wajen kirkirar da buɗe Asibitin Butaro a Arewacin Rwanda a cikin 2011.  Ayyukan kiwon lafiya daga Brigham da Asibitin Mata sun ba da likita, jinya, cututtuka da kula da ciwon daji. A cikin 2013, an buɗe Makarantar Kiwon Lafiya da Asibitin Mirebalais a tsakiyar Haiti, suna ba da horo na makarantar likita ga likitocin Haiti da kula da kiwon lafiya. Tare da hadin gwiwar [Dana-Farber Cancer institute], an bude asibitin ciwon daji a Boao China a cikin 2018. 

## Manazarta