Tasirin barasa akan tsufa

**Tasirin barasa akan tsufa** yana da yawa. Shaidu sun nuna cewa shaye-shaye ko shaye-shaye na iya haifar da saurin tsufa (ko wanda ba a kai ba) - wanda alamun tsufa ke bayyana a baya fiye da na al'ada - da ƙari mai yawa, wanda alamun ke bayyana a lokacin da ya dace amma a cikin nau'in ƙari.  Sakamakon rashin amfani da barasa akan tsarin tsufa ya haɗa da hawan jini, dysrhythmia na zuciya, ciwon daji, cututtuka na gastrointestinal, raunin neurocognitive, asarar kashi, da damuwa na zuciya musamman ma damuwa .  Bugu da ƙari, amfani da ethanol na yau da kullum zai iya taimakawa wajen tsufa da wuri ta hanyar ragewa NAD + salula, mahimmin coenzyme mai mahimmanci don gyaran DNA da kuma kula da lafiyar salula ta hanyar sunadarai kamar sirtuins .    

## Tasirin metabolism da lalacewar salula
Ana ƙara fahimtar amfani da ethanol na yau da kullun don ba da gudummawa ga haɓakar tsufa ta hanyoyi daban-daban, musamman ta hanyar raguwa da canjin ma'auni na nicotinamide adenine dinucleotide (NAD +) .  Metabolism na ethanol, da farko a cikin hanta ta hanyar enzymes irin su barasa dehydrogenase da aldehyde dehydrogenase, yana buƙatar NAD + a matsayin mai haɗin gwiwa, yana canza shi zuwa nau'in da aka rage, NADH. Wannan tsari yana haɓaka ƙimar NADH/NAD+ sosai, yana haifar da ƙarancin ƙarancin NAD+ a cikin sel.   NAD + shine mahimmancin coenzyme don sirtuins, nau'in sunadaran sunadaran da ke da mahimmanci don kula da lafiyar salula, inganta gyaran DNA, daidaita tsarin metabolism, inganta aikin mitochondrial, da inganta juriya na damuwa -duk hanyoyin da ke magance tsufa.  Rage samun NAD + saboda yawan shan barasa na iya lalata ayyukan sirtuin, yana rage waɗannan ayyukan salon salula masu kariya. Bugu da ƙari, barasa da ƙwayar metabolite mai guba acetaldehyde na iya haifar da lalacewar DNA, wanda ke haifar da kunnawa na Poly (ADP-ribose) polymerases (PARPs), enzymes waɗanda ke cinye NAD + sosai a lokacin aikin gyaran DNA, yana kara tsanantawa NAD +.  Ganin cewa matakan NAD + a dabi'a suna raguwa tare da shekaru, wannan barasa ya haifar da rushewar NAD + homeostasis da kuma lalacewar hanyoyin da suka dogara da NAD + na gaba kamar waɗanda sirtuins da PARPs suka shiga tsakani na iya ba da gudummawa ga fasalulluka na haɓaka tsufa da haɓaka haɓakar cututtukan da suka shafi shekaru.  

Barasa ne mai karfi neurotoxin .  Cibiyar Nazarin Alcohol da Alcoholism ta gano, "Shaye-shaye na iya hanzarta tsufa na al'ada ko kuma ya haifar da tsufa na kwakwalwa."  Wani rahoton da wannan hukumar ta samu, "Shan barasa na yau da kullun, da kuma bayyanar glucocorticoid na yau da kullun, na iya haifar da tsufa da / ko ƙari." Musamman, barasa yana kunna axis na HPA, yana haifar da ɓoyewar glucocorticoid kuma ta haka yana haɓaka matakan hormones na damuwa a cikin jiki. Bayyanar cututtuka na yau da kullum ga waɗannan kwayoyin halitta yana haifar da haɓakar tsarin tsufa, wanda ke da alaƙa da "a hankali, amma sau da yawa mai ban mamaki, canje-canje a kan lokaci a kusan kowane tsarin ilimin lissafi a cikin jikin mutum. Haɗe, waɗannan canje-canjen suna haifar da raguwar tasiri da farfadowa na aikin physiological." Damuwa na yau da kullun da amfani da barasa na yau da kullun yana haifar da irin wannan tasirin tsufa wanda bai kai ba, gami da lalata ƙwayoyin jijiya a cikin hippocampus . 

## Manazarta