Folami Ideraabdullah

Folami Ideraabdullah ƙwararriyar masaniyar kwayoyin halitta ce ta Amurka kuma farfesa a fannin ilimin halittar jini da kuma sashen abinci mai gina jiki a Makarantar Gillings ta Lafiyar Jama'a ta Duniya a Jami'ar North Carolina da ke Chapel Hill . Ideraabdullah ta binciko yadda abinci mai gina jiki na uwa da kuma fallasa gubar muhalli ke shafar ci gaba ta hanyar binciko canje-canjen kwayoyin halitta ga DNA. Ta gano cewa rashin bitamin D na uwa na iya haifar da canje-canje a cikin kwayoyin halitta a cikin tsarin methylation wanda ke ci gaba har tsawon tsararraki da dama kuma yana shafar lafiyar 'ya'ya. Haɗin gwiwarta ta ƙasa da ƙasa da Jami'ar Witwatersrand ya kasance karo na farko da aka binciki matakan ƙarfe a cikin mahaifa dangane da sakamakon haihuwa a Afirka ta Kudu .

## Rayuwar farko da ilimi
Ideraabdullah tana son zama masanin kimiyya tun tana ƙarama.  A ajinta na ilimin halittu na makarantar sakandare ne ta fahimci cewa DNA shine tsarin ilimin halittu, kuma wannan ra'ayin ya burge ta.  Tana son fahimtar yadda wannan tsarin zai iya samar da kuma kiyaye lafiyayyen halitta, kuma ta sadaukar da kanta ga kimiyya tun daga lokacin.

A shekarar 1997, Ideraabdullah ta ci gaba da karatun digirinta na farko a Jami'ar Jihar Pennsylvania da ke Jami'ar Park, Pennsylvania .  Ta yi karatun digirinta na farko a fannin ilmin halittu tare da mai da hankali kan ilmin kwayoyin halitta kuma ta binciko damar yin bincike na digiri na farko a dakin gwaje-gwaje na Andrew Clark.  Ta gudanar da binciken kwayoyin halitta a *Drosophila*, wanda ya jagoranci ci gaba da aiki a fannin kwayoyin halitta.  Ideraabdullah ta kammala karatun digirinta na farko a Kimiyya a shekarar 2001. 

Bayan kammala karatun digirinta na farko, Ideraabdullah ta koma Chapel Hill, North Carolina don gudanar da binciken digirinta na biyu a Jami'ar North Carolina da ke Chapel Hill a shekarar 2002.  Ta yi aiki a ƙarƙashin jagorancin Fernando Pardo-Manuel de Villena a Sashen Ilimin Halitta.  Ta binciki bambancin kwayoyin halitta ta hanyar tsarin juyin halitta bayyananne.  Aikinta na farko a dakin gwaje-gwaje ya taimaka wajen fayyace bambancin jerin nau'ikan bera 20 da aka haifa bisa ga maye gurbinsu, saka su, da share su.  Ta gano cewa sharewa ya fi yawa fiye da saka su kuma bambancin jerin ya fi girma a tsakanin waɗannan nau'ikan fiye da na ɗan adam.  Ta gano cewa abubuwan da ke cikin uwa da uba na cutar DDK ba su da alaƙa da halayen kwayoyin halitta da ke bayyana abubuwan da ke haifar da uwa da uba.  Ta kuma bayyana abubuwan da ke canza kwayoyin halitta da ke haifar da yanayin ceto ga cutar DDK.  Ideraabdullah ta kammala karatun digirinta a shekarar 2007.

Bayan kammala karatun digirinta na biyu, Ideraabdullah ta yi aikin digiri na biyu a ƙarƙashin jagorancin Marisa Bartolomei a Makarantar Magunguna ta Perelman da ke Jami'ar Pennsylvania .  A nan, Ideraabdullah ta sami ƙwarewa a nazarin epigenetics. Ta yi nazarin hanyoyin kwayoyin halitta na bugun kwayoyin halitta, inda bayyanar kwayoyin halitta ya dogara ne akan ko an gaji kwayar halittar daga uwa ko uba.  Tunda ana tsammanin daidaita kwayoyin halitta da aka buga ana sarrafa su ta hanyar gyare-gyaren epigenetic zuwa yankin sarrafa bugu (ICR), Ideraabdullah ta bincika ko akwai yankuna a wajen ICR waɗanda ke da mahimmanci wajen daidaita kwayoyin halitta da aka buga.  Ta canza yankuna daban-daban a cikin ICR don H19/IGF2 kuma wannan ya haifar da asarar danne kwayar halittar da aka buga, duk da haka tsarin methylation a yankin ICR da mai haɓaka kwayar halitta da aka buga bai canza ba.  Bincikenta shine na farko da ya nuna cewa hanyoyin da ke wajen ICR suna da mahimmanci don shiga tsakani cikakken yanayin da aka danne kwayar halitta da aka buga.  Bayan wannan binciken, Ideraabdullah ta ƙirƙiri kuma ta siffanta samfurin Beckwith-Wiedemann Syndrome (BWS), wata cuta da ke faruwa sakamakon rashin daidaituwa a cikin bugun kwayoyin halitta.  Ta amfani da wannan kayan aikin, ta bincika yadda ƙananan gogewa a yankin sarrafa bugu don H19/IGF2 ke haifar da rashin daidaituwar alamun epigenetic da bayyanar kwayar halitta da aka buga.  Ta gano cewa gogewar bai shafi methylation na DNA ba, kodayake ya shafi danne kwayar halitta da kuma cewa tasirin gogewa akan aikin rufewa ya ta'allaka ne akan nama, saboda kyallen mesodermal ne kawai suka katse aikin rufewa.  Ideraabdullah ta kammala horon digiri na biyu a shekarar 2012.

## Aiki da bincike
A shekarar 2013, Ideraabdullah ta shiga Sashen Nazarin Halittar Halitta a Jami'ar North Carolina da ke Chapel Hill a matsayin mataimakiyar farfesa.  Ta yi aiki tare a matsayin farfesa a Sashen Nazarin Abinci Mai Gina Jiki a Makarantar Gillings ta Lafiyar Jama'a ta Duniya kuma ita ce memba mai alaƙa da Cibiyar Binciken Abinci Mai Gina Jiki da ke Kannapolis, North Carolina .  Tun daga shekarar 2016, Ideraabdullah ta zama Mai Bincike Mai Girmamawa a Jami'ar Witwatersrand da ke Johannesburg, Afirka ta Kudu a cikin Sashen Binciken Lafiya na MRC/Wits.  Ideraabdullah kuma memba ce a Ƙungiyar Nazarin Halittar Halitta ta Amurka . 

Ideraabdullah ita ce babban mai bincike a dakin gwaje-gwajen Ideraabdullah wanda ke nazarin hanyoyin da muhalli ke gyara epigenome yayin ci gaba.  dakin gwaje-gwajenta yana mai da hankali kan binciken tasirin epigenetic na rashin bitamin D, fallasa magungunan kashe kwari, da kuma hauhawar jini a lokacin daukar ciki. 

### Tasirin abinci mai gina jiki akan yanayin halittar epigenetic
Ɗaya daga cikin nau'ikan gyaran epigenetic shine methylation, don haka abubuwan gina jiki na masu ba da methyl suna taka muhimmiyar rawa a cikin gyare-gyaren epigenetic.  Ideraabdullah tana da sha'awar bincika yadda shan masu ba da methyl a cikin uwa ke shafar ci gaban 'ya'ya.  Ta gano cewa tasirin ƙari na rage cin abinci na methyl tare da maganin rigakafi ya haifar da canjin nauyin jikin ɗan kwikwiyo, girman ɗan kwikwiyo da nasarar zubar da ciki. 

Vitamin D wata muhimmiyar sinadari ce ga methylation, kuma rashin bitamin D matsala ce ta duniya wacce ba a san ta ba ga lafiyar uwa da jariri.  Ideraabdullah ta binciko yadda karancin bitamin D na uwa ke canza methylation da kuma inda aka buga shi.  Ta gano cewa karancin bitamin D a cikin uwaye ya haifar da canjin nauyin jiki da kuma asarar methylation na DNA a cikin tsararraki biyu na 'ya'ya a cikin kyallen somatic da germline.  Don bin wannan binciken, ƙungiyar Ideraabdullah ta binciko tsarin methylation na kwayoyin halitta a cikin maniyyin beraye a cikin sarrafawa idan aka kwatanta da dabbobi masu ƙarancin bitamin D.  Sun gano cewa raguwar ci gaban bitamin D ya haifar da asarar methylation epimutations a yankuna da aka wadatar don kwayoyin halittar ci gaba da rayuwa.  Gabaɗaya, Ideraabdullah ta tabbatar da cewa rashin bitamin D yana da tasiri mai yawa akan canje-canjen epigenetic ga babban germ na maza wanda ya ɗauki tsawon tsararraki da yawa. 

### Tawagar farko ta kwanaki 1000 ta Soweto
Ideraabdullah ta yi aiki tare da Jami'ar Witwatersrand da ke Johannesburg, Afirka ta Kudu don tantance yadda yawan shan ƙarfe ke shafar sakamakon haihuwa.  Bincikensu na farko a shekarar 2019 ya binciki ko matakan ƙarfe a cikin mahaifar wannan ƙungiyar suna da alaƙa da sakamakon haihuwa.  Sun tabbatar da cewa ƙungiyar tana da matakan cadmium mafi girma fiye da ma'aunin ƙungiyoyin duniya, da ƙananan abubuwa masu mahimmanci kamar nickel da chromium.  Sun gano cewa cadmium, selenium, da nickel duk suna da alaƙa da sakamakon mahaifa da haihuwa kuma a halin yanzu suna binciken hanyoyin da wannan alaƙar ke bayyana. 

## Lambobin yabo da girmamawa

* An Sanya Sunan Shekarar 2020 a Manyan Masana Kimiyya Baƙaƙe 100 Masu Wahayi a Amurka ta Cell Press 
* Wanda ya karɓi Bitar Vitamin D ta Matasa Masu Bincike ta 2019 
* Kyautar Majalisar Bincike ta Jami'a ta 2015 - Jami'ar North Carolina 
* Kyautar Ci gaban Malamai ta Ƙaramin IBM ta 2014 - UNC 
* Kyautar Tafiya ta FASEB-MARC ta 2011 - Taron Halittar Jini na GSA 
* Kyautar Canjin Masanin Kimiyya Mai Jagorori na 2010-2011 
* Kyautar Ruth L. Kirschstein ta Ƙasa a Ayyukan Bincike 
* Ƙungiyar 'Yan tsiraru ta Carl Storm ta 2009 
* 2006 Sarah Graham Kenan / Edwards-Hobgood Dissertation Fellowship 

## Zaɓi wallafe-wallafe

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## Manazarta