Donita Brady

**Donita C. Brady** ƙwararriyar masaniyar ilimin halittar cutar kansa ce kuma Farfesa a fannin ilimin halittar cutar kansa ta shugaban ƙasa a Makarantar Magunguna ta Perelman da ke Jami'ar Pennsylvania .  name=":1">   Bincikenta ya binciki yadda ƙwayoyin halitta ke sadarwa ta hanyar kinases da kuma gina jiki, musamman ma, babban aikin jan ƙarfe da sauran ƙarfe a cikin waɗannan hulɗar.

## Rayuwar farko da ilimi
Brady ta girma kusa da Virginia Beach kuma ta sami kwarin gwiwa wajen samun gurbin karatu a fannin Chemistry sakamakon malamarta ta AP Chemistry .  Brady ta yi karatun sinadarai a Jami'ar Radford inda ta kammala karatun magna cum laude .   

## Sana'a
Brady ta kammala karatun digirin digirgir a fannin harhada magunguna a shekarar 2008 a Jami'ar North Carolina, Chapel Hill a dakin gwaje-gwaje na Adrienne D. Cox.    A matsayinta na dalibar digirin digirgir, Brady ta yi nazarin yadda ƙwayoyin cutar kansa ke amfani da ayyukan ƙwayoyin halitta na yau da kullun don canza siffarsu.  Bayan kammala karatun, Brady ta zama ɗalibi na uku (2008 - 2013) kuma babbar abokiyar bincike (2013 - 2015) a dakin gwaje-gwaje na Christopher Counter a Makarantar Magunguna ta Jami'ar Duke .   A shekarar 2015, ta shiga Sashen Ilimin Halittar Ciwon daji a Makarantar Magunguna ta Perelman a Jami'ar Pennsylvania a matsayin mataimakiyar farfesa.  A shekarar 2016, an amince da Brady a matsayin ɗaya daga cikin ƙwararrun Pew Scholars in Biomedical Sciences ta The Pew Charitable Trusts.  A shekarar 2019, an ba Brady tallafin kuɗi ta Asusun Binciken Ciwon daji na Stuart Scott Memorial don ci gaba da aikinta a binciken PDAC ( pancreatic ductal adenocarcinoma ). 

### Abubuwan bincike masu sha'awa
Binciken Brady ya mayar da hankali kan yadda ƙwayoyin halitta ke sadarwa ta hanyar kinases da kuma gina jiki,  da kuma babban rawar da ƙarfe kamar jan ƙarfe ke takawa a cikin lafiyar ƙwayoyin halitta da kuma ciwon daji.    Ta gano cewa kinases suna buƙatar jan ƙarfe don ikonsu na aiki.  Brady ta kuma nuna cewa ta hanyar hana wani furotin da ake kira CTR1, wanda ke da alhakin shigo da jan ƙarfe cikin ƙwayoyin halitta, ana iya rage girman ciwon a cikin samfurin linzamin kwamfuta. 

### Lambobin yabo da girmamawa
Brady ta sami kyaututtuka da kyaututtuka da dama saboda bincikenta, ciki har da:

* Kyautar James Lewis Howe don Nasara Mai Kyau a Kimiyyar Sinadarai - Ƙungiyar Sinadarai ta Amurka (2003) 
* Kyautar Binciken Ciwon daji ta AACR ta Shekara-shekara 
* Masanin CRCHD CURE (2014) 
* Pew Scholar a fannin kimiyyar halittu (2016) 
* Kyautar JBC/Gerb Tabor Young Investigator Award (2016) 
* Masanin Gidauniyar Bincike ta William Guy Forbeck (2017) 
* Kyautar Linda Pechenik Montague Mai Bincike (2018)

### Littattafai da aka zaɓa

* Brady, Donita C., da sauransu. "Ana buƙatar jan ƙarfe don siginar BRAF mai haifar da kansa da kuma ciwace-ciwacen daji." *Nature* 509.7501 (2014): 492–496.
* Brady, Donita C., da sauransu. "Celation na jan ƙarfe yana hana BRAFV600E-driven melanoma kuma yana ƙin juriya ga masu hana BRAFV600E da MEK1/2." *Binciken Ciwon daji* 77.22 (2017): 6240–6252.
* Sadeghi, Rochelle Shirin. "Fosphorylation na Wnt5a Signaling Induced yana Ƙara Ayyukan Acyl Protein Thioesterase Kuma Yana Haɓaka Halin Metastatic na Melanoma." (2018).
* Kim, Ye-Jin, da sauransu. "Ana buƙatar ATOX1 mai kula da jan ƙarfe don siginar MAPK da girma a cikin melanoma mai kama da maye gurbi na BRAF." *Metallomics* 11.8 (2019): 1430–1440.
* Kim, Ye-Jin, da sauransu. "Hana membobin iyali na BCL2 yana ƙara ingancin chelation na jan ƙarfe a cikin melanoma da BRAFV600E ke tuƙi." *Binciken Ciwon daji* 80.7 (2020): 1387–1400.
* Tsang, Tiffany, da sauransu. "Copper muhimmin abu ne na daidaita autophagic kinases ULK1/2 don haifar da adenocarcinoma na huhu." *Nature Cell Biology* 22.4 (2020): 412–424.

## Rayuwa ta sirri
A Jami'ar Radford, Brady ya buga ƙwallon ƙafa ta Division I. 

## Hanyoyin haɗi na waje

* Brady Lab a Makarantar Likitanci ta Perelman
* Shafin malamai na Donita Brady a Jami'ar Pennsylvania

## Manazarta