Allurar rigakafin globulin

Ana yin **allurar rigakafi ta globulin** ( **VIG** ) daga tarin jinin mutanen da aka yiwa allurar rigakafin cutar sankarau . *Kwayoyin rigakafin* waɗannan mutane da aka samar domin amsar maganin ƙwayar cuta ana cire su kuma ana tsarkake. Wannan yana haifar da VIG. Ana iya gudanar da shi ta cikin jini. Ana amfani da shi don kula da mutanen da suka sami ci gaba na rigakafi bayan rigakafin ƙwayar cuta.

An kuma yi amfani da shi tare da cidofovir don barkewar cutar sankarau ta Midwest ta shekarar 2003 a matsayin magani tare don rage mummunar illar rigakafin cutar sankarau.   Bugu da kari, CDC ta bayyana cewa ana iya la'akari da amfani da VIGIV don rigakafin kamuwa da cutar kyandar biri a cikin mutanen da aka fallasa waɗanda ba za su iya samun rigakafin cutar bayan bayyanar da maganin ƙanƙara ba saboda tsananin ƙarancin aikin T-cell. 

## Mummunan illar rigakafin cutar sankarau
Ga ƙaramin kaso na yawan jama'a, maganin ƙanƙara ko dai ba ya "ɗauka" ko kuma yana haifar da munanan al'amura . Waɗannan sun haɗa da cututtukan ƙwayoyin cuta na tsakiya na gaba, alurar riga kafi, eczema vaccintum, implantation na bazata, "gaɗaɗɗen alurar riga kafi", da rashes na erythematous ko urticarial na kowa.   

## Ci gaban rigakafi globulin
A ƙarshen 1940s, Henry Kempe ya ba da shawarar cewa maganin rikice-rikicen rigakafin ƙwayar cuta shine samar da ƙwayoyin rigakafi a cikin nau'in gamma globulin, magani na likita wanda aka sani da rigakafi mara kyau .   Kempe ya lura cewa ga wasu jarirai, maganin furucin ya kasa "ɗauka". Kempe ya yi imanin wannan gazawar na iya kasancewa saboda yawan matakan rigakafin rigakafi na uwa zuwa alurar riga kafi a cikin jinin jarirai. Ya bayyana ga Kempe cewa kasancewar ƙwayoyin rigakafi sun toshe kwafin kwayar cuta, sabili da haka zubar da ƙwayoyin rigakafi daga mutanen da ke da rigakafi saboda rigakafin zai taimaka wa waɗanda allurar rigakafin ta gaza. 

Magungunan ƙwayoyin cuta guda biyu na VIG (VIGIV Cangene da VIGIV Dynport) sun sami lasisi ta FDA don kula da marasa lafiya da ke da ci gaba da alurar riga kafi, eczema alurar riga kafi, ƙwayar cuta ta gabaɗaya, da kuma shigar da ƙasa mai yawa ko sanyawa na lokaci-lokaci bin inoculation ba da gangan ba.  

Cangene (wani reshe na Emergent BioSolutions) iri-suna VIGIV kuma ana san shi da wani madadin suna: C-VIG; CNJ 016; NP 016 - Cangene; VIG; VIGIV - Abubuwan Halittu na gaggawa.  An yi amfani da irin wannan nau'in magani da ake kira antiserum a cikin jiyya da yawa cikin nasara, kuma an kammala wasu bincike da gwaje-gwaje na asibiti don amfani da shi wajen magance cutar kyandar biri. 

An sabunta binciken farko na tallace-tallace a cikin 2021 don tabbatar da fa'idodin asibiti na VIGIV (CNJ-016, Vaccinia Immune Globulin Intravenous (Dan Adam), maganin bakararre) a cikin ƙudurin rikice-rikicen da ke haifar da alurar rigakafin Orthopoxvirus a cikin marasa lafiya da suka cancanta bi da VIGIV mai suna *Clinical Sakamako na VIGIV Maganin Maganin Cutar Kanjamau ko Kamuwar Alurar riga kafi* . 

## Alurar rigakafin Orthopoxvirus
Ana ba da shawarar allurar rigakafi na globulin (VIGIV) azaman layin farko na jiyya don magance mummunan halayen da ke haifar da ci gaba da kwafin ƙwayar cutar alurar riga kafi bayan yin allurar ta amfani da ACAM2000 ko APSV.     

Ba a samun VIGIV na kasuwanci amma ana iya samarwa ta hanyar Strategic National Stockpile (SNS) don magance rikice-rikicen rigakafin cutar sankarau a cikin marasa lafiya da alamun bayyanar asibiti.

Sauran jiyya sune

* Cidofovir
* Brincidofovir (TEMBEXA)
* Tecovirimat (ST-246 ko sunan sa Tpoxx)

Ana samun jagororin sarrafa maganin rigakafin Orthopoxvirus (Smallpox) daga Cibiyar Kula da Cututtuka da Cututtuka. 

Littattafan da *aka ci gaba da cutar sasanta: Caseply Case da magani-shiryayyar rigakafi tare da Alcta* idan basu da lafiya. 

Mutanen da ke da cutar HIV da AIDS suna cikin haɗarin haɓaka halayen halayensu da lahani yayin da suke da Orthopoxvirus. Littattafai irin su *Progressive Vaccinia An samu ta hanyar Zoonotic Transmission a cikin Mara lafiya mai HIV/AIDS* ya sake bayyana a cikin sharuddan asibiti dalilin da ya sa marasa lafiya da ke da ƙarancin rigakafi (daga kamuwa da cutar HIV, ko kuma daga duk wani yanayin kiwon lafiya da ke shafar tsarin rigakafi) suna cikin haɗari mai yawa.  Hakazalika, jarirai (da kuma ta tsawaita a lokacin daukar ciki), da kuma tsofaffi tare da yanayin kiwon lafiya da suka rigaya sun fi dacewa da halayen halayen.  Ga mutanen da ke shan maganin rigakafi don ƙarancin rigakafi, VIGIV yana da suna daban kuma yana ga takamaiman yanayin (idan sun sami necrosis daga maganin ƙanƙara) maimakon magani na gabaɗaya don rashin ƙarfi.  Wadannan ( IgG, IgA, IgM, IgD, da IgE ) a baya an yi bincike don amfani da kwayar cutar Vaccinia Ankara, fiye da VIGIV a matsayin maganin cutar sankarau.  

## Duba kuma

* Cangene
* Eczema alurar riga kafi
* Gamma globulin
* Immunoglobulin far - bayyani na wannan batu.
* Alurar riga kafi

## Hanyoyin haɗi na waje

* 
* CDC Smallpox Home
* Quick Guide to Preexposure Smallpox Vaccination
* U.S. Food and Drug Administration – Vaccinia Immune Globulin Intravenous (Human) Supporting Documents older than three years
* Vaccinia Immune Globulin Intravenous Product Information (this pamphlet is included with the medicine)

## Manazarta