Christine Holt

**Christine Elizabeth Holt** (an haife ta a ranar 28 ga watan Agustan shekara ta 1954) masanin kimiyyar kwakwalwa ce ta Burtaniya.

Ta kasance Farfesa a fannin Neuroscience, Jami'ar Cambridge,  tun daga shekara ta 2003 kuma Fellow na Gonville da Caius College, Jami'an Cambridge,  tun daga shekara.

Holt an fi saninta da aikinta na fahimtar "tushen hanyoyin da ke jagorantar yadda kwakwalwar vertebrate ke shiga cikin takamaiman hanyar da ta dace. "  A shekara ta 2009, ta kasance wani ɓangare na ƙungiyar ƙasa da ƙasa da ta sami tallafin Shirin Kimiyya na Human Frontiers don haɓaka binciken kwayoyin da zai taimaka wa masu bincike su fahimci tsarin "GPS na sel" wanda ke jagoranta neurons don ƙirƙirar tsarin juyayi mai kyau. " Binciken ta yana ba da jagora don maganin gaba don lalacewar jijiyoyi da cututtukan neurodevelopmental.

## Ayyukan kimiyya

A shekara ta 1977, Holt ta sami digiri na farko na Kimiyya (Honors) a kimiyyar halittu daga Jami'ar Sussex . Ta yi aikin digirin digirin ta a karkashin jagorancin John Scholes a Kwalejin King ta London, inda ta sami Ph.D. a fannin ilimin dabbobi a shekarar 1982. 

Daga 1982 zuwa 1986, ta kasance abokiyar postdoctoral a Sashen Physiology a Jami'ar Oxford da Sashen Biology na Jami'ar California San Diego (UCSD) a karkashin jagorancin W.A. Harris da Colin Blakemore .  A shekara ta 1986, ta zama mataimakiyar masanin kimiyyar halittu da kuma malami a UCSD, inda ta ci gaba da nazarin tsarin gani na kwaya a farkon lokacin da ta fara. Ta sami lambar yabo ta McKnight Scholar Award  don wannan aikin a 1986 da kuma lambar yabo ta Alexander von Humboldt a 1987. 

Ta shiga bangaren koyarwa a UCSD a shekarar 1989. A wannan lokacin, ta yi nazarin tsarin da sel daga retina ke girma zuwa kuma suna yin haɗin kai tare da takamaiman sel na kwakwalwa, suna yin gwaje-gwaje don fahimtar rawar da ƙwayoyin mannewa ke takawa a cikin jagorancin axon. Musamman, ta tantance asarar N-cadherin da integrins, biyu daga cikin nau'ikan kwayoyin mannewa guda uku, a kan kwakwalwar embryonic.[1] A shekara ta 1991, an ba ta suna Pew Scholar .

A shekara ta 1997, ta koma Kwalejin Gonville &amp;amp; Caius a Jami'ar Cambridge .  A shekara ta 2003, ta zama Farfesa a fannin Neuroscience a Sashen Physiology, Development da Neuroscience, matsayin da take riƙewa a yau. An zabe ta a matsayin memba na Kungiyar Kwayoyin Kwayoyin Kwayar Turai a shekara ta 2005, abokiyar Kwalejin Kimiyya ta Kiwon Lafiya a shekara ta 2007, kuma abokiyar Royal Society a shekara ta 2009. A shekara ta 2011, an ba ta lambar yabo ta Remedios Caro Almela don Bincike a cikin Neurobiology na Ci Gaban. A shekara ta 2016, ta kasance daga cikin ƙungiyar da aka ba da kyautar António Champalimaud Vision Award,  tare da John Flanagan na Makarantar Kiwon Lafiya ta Harvard, Carol A. Mason na Jami'ar Columbia, Carla Shatz na Jami'an Stanford. A cikin 2017, Farfesa Holt ta sami lambar yabo ta Ferrier da Lacca ta Royal Society "don fahimtar mahimman hanyoyin kwayoyin da ke cikin ci gaban jijiyoyi, jagora da niyya wanda ya sauya iliminmu game da haɓaka axon. "  A cikin 2022 ta sami lambar Rosenstiel,  kuma a cikin 2023 Kyautar Brain. 

An zabi Christine Holt a matsayin memba na Kwalejin Kimiyya ta Kasa a watan Afrilun 2020. 

## Manazarta