Frontotemporal dementia

**Frontotemporal dementia** (**FTD**), dem sanso call **frontotemporal degeneration disease** anaa **frontotemporal neurocognitive disorder**, dey encompass several types of dementia wey dey involve de progressive degeneration of de brain ein frontal den temporal lobes. Men den women appear to be equally affected. FTD generally dey present as a behavioral anaa language disorder plus gradual onset. Signs den symptoms tend to appear insyd mid adulthood, typically between de ages of 45 den 65, although e fi affect people younger anaa older dan dis. As of 2017 der be no cure anaa approved symptomatic treatment give FTD, although na dem prescribe sam off-label drugs den behavioral methods.

Na dem first describe features of FTD by Arnold Pick between 1892 den 1906. Na dem coin de name *Pick's disease* insyd 1922, buh na dem reserve am for de behavioral variant of FTD, insyd wich characteristic Pick bodies den Pick cells be present. Na dem first describe dese by Alois Alzheimer insyd 1911. Common signs den symptoms dey include significant changes insyd social den personal behavior, disinhibition, apathy, blunting den dysregulation of emotions, den deficits insyd both expressive den receptive language.

Each FTD subtype relatively be rare. FTDs mostly be early onset syndromes dem link to frontotemporal lobar degeneration (FTLD), wich be characterized by progressive neuronal loss predominantly wey dey involve de frontal anaa temporal lobes, den a typical loss of more dan 70% of spindle neurons, while oda neuron types remain intact. De three main subtypes anaa variant syndromes be a behavioral variant (bvFTD) dem previously know as Pick's disease, den two variants of primary progressive aphasia (PPA): semantic (svPPA) den nonfluent (nfvPPA). Two rare distinct subtypes of FTD be neuronal intermediate filament inclusion disease (NIFID) den basophilic inclusion body disease (BIBD). Oda related disorders dey include corticobasal syndrome (CBS anaa CBD), den FTD plus amyotrophic lateral sclerosis (ALS).

## Notable cases
People wey na dem be diagnosed as having FTD (dem often refer to as *Pick's disease* in cases of de behavioral variant) dey include:

* John Berry (1963–2016), American hardcore punk musician den founding member of de Beastie Boys
* Clancy Blair (1960–2024), American developmental psychologist den professor
* Don Cardwell (1935–2008), Major League Baseball pitcher
* Charmian Carr (1942–2016), wey play Liesl, from de *Sound of Music*, dem born Charmian Anne Farnon

* Jerry Corbetta (1947–2016), frontman, organist den keyboardist of American psychedelic rock band Sugarloaf
* Ted Darling (1935–1996), Buffalo Sabres television announcer

* Robert W. Floyd (1936–2001), computer scientist
* Lee Holloway (born 1982), computer scientist, co-founder of Cloudflare
* Colleen Howe (1933–2009), sports agent den ice hockey team manager, dem know as "Mrs. Hockey"

* Kazi Nazrul Islam (1899–1976) national poet of Bangladesh
* Terry Jones (1942–2020), Welsh comedian (Monty Python) den director
* Ralph Klein (1942–2013), former premier of Alberta, Canada

* Kevin Moore (1958–2013), English footballer
* Ernie Moss (1949–2021), English footballer
* Nic Potter (1951–2013), British bassist for Van der Graaf Generator
* Christina Ramberg (1946–1995), American painter wey associate plus de Chicago Imagists

* David Rumelhart (1942–2011), American cognitive psychologist
* Sir Nicholas Wall (1945–2017), English judge
* Bruce Willis (born 1955), American actor
* Mark Wirtz (1943–2020), pop musician, composer den producer
* Curtis Hanson (1945–2016), American film director, screenwriter, den producer

## References


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## External links

* Patient group