Lysergic acid diethylamide

**Lysergic acid diethylamide**, dem commonly know as **LSD** (from German ) den by de slang names **acid** den **lucy**, be a semisynthetic hallucinogenic drug dem derive from ergot, dem know for ein powerful psychological effects den serotonergic activity. Na dem historically use am insyd psychiatry den 1960s counterculture; e be currently legally restricted buh dey experience renewed scientific interest den increasing use.

When dem take orally, LSD get an onset of action within 0.4 to 1.0 hours (range: 0.1–1.8 hours) den a duration of effect wey dey last 7 to 12 hours (range: 4–22 hours). Dem commonly dey administer am via tabs of blotter paper. LSD be extremely potent, plus noticeable effects at doses as low as 20 micrograms wey dem sam times dey take am insyd much smaller amounts for microdosing. Despite widespread use, dem no document fatal human overdoses. Dem mainly dey use LSD recreationally anaa for spiritual purposes. LSD fi cause mystical experiences. LSD dey exert ein effects primarily thru high-affinity wey dey bind to chaw serotonin receptors, especially 5-HT2A, den to a lesser extent dopaminergic den adrenergic receptors. LSD dey reduce oscillatory power insyd de brain ein default mode network den dey flatten brain hierarchy. At higher doses, e fi induce visual den auditory hallucinations, ego dissolution, den anxiety. LSD use fi cause adverse psychological effects such as paranoia den delusions den fi lead to persistent visual disturbances dem know as hallucinogen persisting perception disorder (HPPD).

Na Swiss chemist Albert Hofmann first synthesize LSD insyd 1938 wey na he discover ein powerful psychedelic effects insyd 1943 after accidental ingestion. Na e cam be widely studied insyd de 1950s den 1960s. Na dem initially explore am for psychiatric use secof ein structural similarity to serotonin den safety profile. Na dem use am experimentally insyd psychiatry for treating alcoholism den schizophrenia. By de mid-1960s, na LSD cam be central to de youth counterculture insyd places like San Francisco den London, dey influence art, music, den social movements thru events like Acid Tests den figures such as Owsley Stanley den Michael Hollingshead. Na ein psychedelic effects inspire distinct visual art styles, music innovations, wey na e cause a lasting cultural impact. However, na ein association plus de counterculture movement of de 1960s lead to ein classification as a Schedule I drug insyd de U.S. insyd 1970. Na dem sanso list am as a Schedule I controlled substance by de United Nations insyd 1971 wey remain widout approved medical uses.

Despite ein legal restrictions, LSD remain influential insyd scientific den cultural contexts. Na research on LSD decline secof cultural controversies by de 1960s, buh na e resurge since 2009. Insyd 2024, na de U.S. Food and Drug Administration designate a form of LSD (MM120) a breakthrough therapy for generalized anxiety disorder. As of 2017, na about 10% of people insyd de U.S. use LSD at sam point, na 0.7% use am insyd de past year. Na usage rates rise, plus a 56.4% increase insyd adult use insyd de U.S. from 2015 to 2018.

## References


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## External links

* LSD - Isomer Design
* LSD - PsychonautWiki
* LSD - Erowid
* LSD - TiHKAL - Erowid
* LSD - TiHKAL - Isomer Design
* Lysergide (LSD) drug profile - EUDA (European Union Drugs Agency)

### Documentaries
* ''Hofmann's Potion''  a documentary on the origins of LSD, 2002
* ''Inside LSD'' National Geographic Channel, 2009
* *[https://www.netflix.com/de-en/title/80229847 How to Change Your Mind] * Netflix docuseries, 2022