Maria Manuel Mota

**Maria Manuel Dias da Mota** (Vila Nova de Gaia, Portugal, 1971ko apirilaren 27a) portugaldar zientzialaria da.

1992an, Oportoko Unibertsitatean, biologiako lizentziatura eskuratu zuen, immunologiako maisutasuna eginez 1994an, eta parasitologia molekularreko doktoretza 1998an, Parasitologia Molekularra tesia defendatuz Londresko University College-n (RU). Jarduera akademikoak egiten ditu Medikuntza Molekularreko Institutuan (IMM), Malaria Unitateko ikertzaile nagusi gisa. Eta 2005az geroztik, irakasle gonbidatua da Lisboako Unibertsitateko Medikuntza Fakultatean.

## Zenbait argitalpen 
* Malaria . 2012. *Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug*. J Infect Dis. 205(8): 1278-86

* . 2011. *Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Anti-Malarial Strategy*. Antimicrob Agents Chemother

* . 2011. *Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio*. PLoS Pathog 7(5):e1002046

* . 2011. *Host-mediated control of Malaria Superinfection*. Nature Medicine 17 (6): 732-7

* . 2011. *Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing*. Malar J. 10:74

* . 2011. Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host*. Malar J. 10(1):71*

* . 2011. ''Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle*. Antimicrob Agents Chemother 55(6): 2824-30

* . 2011. *The relevance of non-human primate and rodent malaria models for humans*. Malar J. 10(1): 23

* . 2011. *Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure-Antimalarial Activity Relationships and Mechanistic Studies*. J Med Chem. 54(3): 734

* . 2010. *Accumulation of Plasmodium-infected red blood cells in the brain is crucial for the development of cerebral malaria in mice*. Infect Immun. 78(9): 4033-9

* . 2010. *Crystal Structure of Arginase from Plasmodium falciparum and Implications for l-Arginine Depletion in Malarial Infection*. Biochemistry 49(26): 5600-8

* . 2010. *VEGF promotes malaria-associated acute lung injury in mice*. PLoS Pathog 6(5): e1000916

* . 2010. *Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility*. Cell Microbiol. 2(4): 506

* . 2009. *Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging*. PLoS One 4(11): e7881

## Patenteak 
* Hepatozitoen hazkuntza-faktorearen antagonistek gizakietan malariaren infekzioa prebenitzeko metodoa. Hegoafrika: patentea. 2005/ 08178. International PCT Publication N oinarri hartuta.º. WO2004/080420, African Reg. Adierazlea Prop. Erak. – Application Zk. AP/P/2005/003411, Brasil – Aplikazio zk.: PI040826 8-0, Txina – argitalpen zk. CN1809382A, Europa – argitalpen zk. 601378, Hong Kong – argitalpen zk. 1093903A, Japonia – N.º aplikazioa. 2006-507105, AEB AEB.- argitalpen zk. US 2004-0185050 A1

* Gaixotasun infekziosoak tratatzeko scavenger proteina hartzaileen inhibitzaileak erabiltzea (WO/2007/101710), nazioarteko aplikazioa.º. PCT/EP2007/002110, AEBetan hasitako estatu mailako faseak. AEB., EB, Kanada, Txina 2008ko urrian

* Hartzaileen kinasaren inhibitzaileak erabiltzea gaixotasun infekziosoak tratatzeko, AEBen behin-behineko aplikazioa. AEB. E.º. 61/110,217, 2008ko urriaren 31n artxibatua

## Ohoreak 
* Associação Viver a Ciência elkarteko lehendakaria.
* Lantokiko Prestakuntzaren 2012ko beka

## Ikus, gainera 
* . 2012. *A novel Carbon Monoxide-Releasing Molecule (CO-RM) fully protects mice from Severe Malaria''. Antimicrob Agents Chemother. 56 (3): 1281-90

## Erreferentziak 
## Kanpo estekak