VPS13D

**Protein 13D pridružen vakuolskom sortiranju**
jest protein koji je kod ljudi kodiran genom **VPS13D**  sa hromosoma 1.

## Aminokiselinska sekvenca
Dužina polipeptidnog lanca je  4.388 aminokiselina, a molekulska težina  491.916 Da.

1020304050
MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKEL
ELPFEVKAGFIGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDE
KEKLLERERKKALLQALEEKWKNDRQQKGESYWYSVTASVVTRIVENIEL
KIQDVHLRFEDGVTNPSHPFAFGICIKNVSMQNAVNEPVQKLMRKKQLDV
AEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLEPVFASALLKR
NCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQV
KFRRWKPKVAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAV
SYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQE
ELAESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPGWGGWYGQQTPE
GNVVEGLSAEQQEQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLN
LQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESLPRRNSSLLSV
RLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYP
AADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFFY
KGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDF
IEESKRWTVRLDISAPQVIFPDDFKFKNPVLVVVDLGRMLLTNTQDNSRR
KSRDGSASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFS
EEQLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVE
KFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFAL
LTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHTREVLV
ESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTV
HGLLLVDTMQTYGADFDLLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVA
HLTDGATLNDRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMNLDSTL
QVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQPLMTDFERSF
REQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGG
TKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYENIISD
IGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFL
KELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTR
EPFILEENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVG
HLGQIFIQNFVAGDDESRSDRLQVEIKDIKLYSLNCTQLAGREAVGSEGS
RMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQFKLEKI
PIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLD
NLVYSEDLNKYPASATSSPCPDSPLPPLSTCGESSVERKENGLFSHSSLS
NTSQKSLSVKEVKSFTQIQATFCISELQVQLSGDLTLGAQGLVSLKFQDF
EVEFSKDHPQTLSIQIALHSLLMEDLLEKNPDSKYKNLMVSRGAPKPSSL
AQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQRPTSASRKKQ
KEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEFS
SSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHAMRLPPEG
ILHNVKLEPHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSK
LVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGEEALIFQTF
KYGRPDPLLRREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVL
GRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLG
KLKVKNKFLFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGT
HSQGQFTMPLAGMSLGSLKSEFVPSTSTKQQGPQPTLSVGQESSSPEDHV
CLLDCVVVDLQDMDIFAAERHPREYSKAPEDSSGDLIFPSYFVRQTGGSL
LTEPCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGL
LENNLGEPIEEFMRPYDLQDPRIHTVLSGEVYTCMCFLIDMVNVSLELKD
PKRKEGAGSLARFDFKKCKLLYESFSNQTKSINLVSHSMMAFDTRYAGQK
TSPGMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRV
FLIFDWLLLVHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKSGVV
TKRSSLPVSNERHLEVKVNVTGTEFVVIEDVSCFDTNAIILKGTTVLTYK
PRFVDRPFSGSLFGIEVFSCRLGNEHDTALSIVDPVQIQMELVGNSSYQN
SSGLMDAFNSEDFPPVLEIQLQALDIRLSYNDVQLFLAIAKSIPEQANAA
VPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLELQLARLQELGF
SMDDCRKALLACQGQLKKAASWLFKNAEPLKSLSLASTSRDSPGAVAAPL
ISGVEIKAESVCICFIDDCMDCDVPLAELTFSRLNFLQRVRTSPEGYAHF
TLSGDYYNRALSGWEPFIEPWPCSVSWQQQAASRLHPPRLKLEAKAKPRL
DINITSVLIDQYVSTKESWMADYCKDDKDIESAKSEDWMGSSVDPPCFGQ
SLPLVYLRTRSTASLTNLEHQIYARAEVKTPKRRQPFVPFALRNHTGCTL
WFATLTTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEWREVLTGEEIP
FEFEARGKLRHRHTHDLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPD
KNSSSSTIGSPSSRTNIIHPQVYFSSLPPVRVVFAVTMEGSARKVITVRS
ALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSWRLQA
RPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRFCVAIK
KENYPDYMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKG
MPINGTLKPGKEAALHTADTSQNIELGVSLENFPLCKELLIPPGTQNYMV
RMRLYDVNRRQLNLTIRIVCRAEGSLKIFISAPYWLINKTGLPLIFRQDN
AKTDAAGQFEEHELARSLSPLLFCYADKEQPNLCTMRIGRGIHPEGMPGW
CQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIFA
PRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDY
DQLLCVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRG
ATYRISFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLRTEVKPMTSLD
YAWDEPTLPPFITLTVKGAGSSEINCNMNDFQDNRQLYYENFIYIAATYT
FSGLQEGTGRPVASNKAITCAELVLDVSPKTQRVILKKKEPGKRSQLWRM
TGTGMLAHEGSSVPHNPNKPSAARSTEGSAILDIAGLAAVTDNRYEPLML
RKPDRRRSTTQTWSFREGKLTCGLHGLVVQAKGGLSGLFDGAEVVLGPDT
SMELLGPVPPEQQFINQKMRPGSGMLSIRVIPDGPTRALQITDFCHRKSS
RSYEVDELPVTEQELQKLKNPDTEQELEVLVRLEGGIGLSLINKVPEELV
FASLTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLYVTPLSNE
NEVIETGPAVQVNAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLL
SFFGYDQAESEVEKYDENLHEKTAEQGGTPIRYYFENLKISIPQIKLSVF
TSNKLPLDLKALKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDIL
KHFQEELLSQAARILGSVDFLGNPMGLLNDVSEGVTGLIKYGNVGGLIRN
VTHGVSNSAAKFAGTLSDGLGKTMDNRHQSEREYIRYHAATSGEHLVAGI
HGLAHGIIGGLTSVITSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGA
LDFASETAQAVRDTATLSGPRTQAQRVRKPRCCTGPQGLLPRYSESQAEG
QEQLFKLTDNIQDEFFIAVENIDSYCVLISSKAVYFLKSGDYVDREAIFL
EVKYDDLYHCLVSKDHGKVYVQVTKKAVSTSSGVSIPGPSHQKPMVHVKS
EVLAVKLSQEINYAKSLYYEQQLMLRLSENREQLELDS

## Funkcija
Ovaj gen kodira protein koji pripada porodici gena vakuolskih-sortirajućih proteina-13. U kvascima, vakuolno-protein-sortirajući-13 proteini uključeni su u promet membranskih proteina između trans-Golgi jeve mreže i prevakuolskog odjeljka.

Iako za ovaj gen može postojati nekoliko varijanti transkripta, do danas su opisane pune prirode samo dvije. Ova dva predstavljaju glavne varijante ovog gena i kodiraju različite izoforme.

## Reference
## Dopunska literatura
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Kategorija:Geni na hromosomu 1
Kategorija:Ljudski proteini
Kategorija:Proteomika