MDN1

**Midazinski homolog MDN1** (kvasac) jest protein koji je kod ljudi kodiran genom **MDN**. Midazin je član porodice AAAATPaza.

## Aminokiselinska sekvenca
Dužina polipeptidnog lanca je  5.596 aminokiselina, а molekulska težina  632.820 Da.

1020304050
MEHFLLEVAAAPLRLIAAKNEKSRSELGRFLAKQVWTPQDRQCVLSTLAQ
LLLDKDCTVLVGRQLRPLLLDLLERNAEAIKAGGQINHDLHERLCVSMSK
LIGNHPDVLPFALRYFKDTSPVFQRLFLESSDANPVRYGRRRMKLRDLME
AAFKFLQQEQSVFRELWDWSVCVPLLRSHDTLVRWYTANCLALVTCMNEE
HKLSFLKKIFNSDELIHFRLRLLEEAQLQDLEKALVLANPEVSLWRKQKE
LQYLQGHLVSSDLSPRVTAVCGVVLPGQLPAPGELGGNRSSSREQELALR
SYVLVESVCKSLQTLAMAVASQNAVLLEGPIGCGKTSLVEYLAAVTGRTK
PPQLLKVQLGDQTDSKMLLGMYRCTDVPGEFVWQPGTLTQAATMGHWILL
EDIDYAPLDVVSVLIPLLENGELLIPGRGDCLKVAPGFQFFATRRLLSCG
GNWYRPLNSHATLLDKYWTKIHLDNLDKRELNEVLQSRYPSLLAVVDHLL
DIYIQLTGEKHHSWSDSSVGCEQAPEEVSEARRENKRPTLEGRELSLRDL
LNWCNRIAHSFDSSSLSASLNIFQEALDCFTAMLSEHTSKLKMAEVIGSK
LNISRKKAEFFCQLYKPEIVINELDLQVGRVRLLRKQSEAVHLQREKFTF
AATRPSSVLIEQLAVCVSKGEPVLLVGETGTGKTSTIQYLAHITGHRLRV
VNMNQQSDTADLLGGYKPVDHKLIWLPLREAFEELFAQTFSKKQNFTFLG
HIQTCYRQKRWHDLLRLMQHVHKSAVNKDGKDSETGLLIKEKWEAFGLRL
NHAQQQMKMTENTLLFAFVEGTLAQAVKKGEWILLDEINLAAPEILECLS
GLLEGSSGSLVLLDRGDTEPLVRHPDFRLFACMNPATDVGKRNLPPGIRN
RFTELYVEELESKEDLQVLIVDYLKGLSVNKNTVQGIINFYTALRKESGT
KLVDGTGHRPHYSLRTLCRALRFAASNPCGNIQRSLYEGFCLGFLTQLDR
ASHPIVQKLICQHIVPGNVKSLLKQPIPEPKGGRLIQVEGYWIAVGDKEP
TIDETYILTSSVKLNLRDIVRVVSAGTYPVLIQGETSVGKTSLIQWLAAA
TGNHCVRINNHEHTDIQEYIGCYTSDSSGKLVFKEGVLIDAMRKGYWIIL
DELNLAPTDVLEALNRLLDDNRELLVTETQEVVKAHPRFMLFATQNPPGL
YGGRKVLSRAFRNRFVELHFDELPSSELETILHKRCSLPPSYCSKLVKVM
LDLQSYRRSSSVFAGKQGFITLRDLFRWAERYRLAEPTEKEYDWLQHLAN
DGYMLLAGRVRKQEEIDVIQEVLEKHFKKKLCPQSLFSKENVLKLLGKLS
TQISTLECNFGHIVWTEGMRRLAMLVGRALEFGEPVLLVGDTGCGKTTIC
QVFAALANQKLYSVSCHLHMETSDFLGGLRPVRQKPNDKEEIDTSRLFEW
HDGPLVQAMKEDGFFLLDEISLADDSVLERLNSVLEVEKSLVLAEKGSPE
DKDSEIELLTAGKKFRILATMNPGGDFGKKELSPALRNRFTEIWCPQSTS
REDLIQIISHNLRPGLCLGRIDPKGSDIPEVMLDFIDWLTHQEFGRKCVV
SIRDILSWVNFMNKMGEEAALKRPEIISTVTSFVHAACLVYIDGIGSGVT
SSGFGTALLARKECLKFLIKRLAKIVRLTEYQKNELKIYDRMKAKEFTGI
DNLWGIHPFFIPRGPVLHRNNIADYALSAGTTAMNAQRLLRATKLKKPIL
LEGSPGVGKTSLVGALAKASGNTLVRINLSEQTDITDLFGADLPVEGGKG
GEFAWRDGPLLAALKAGHWVVLDELNLASQSVLEGLNACFDHRGEIYVPE
LGMSFQVQHEKTKIFGCQNPFRQGGGRKGLPRSFLNRFTQVFVDPLTVID
MEFIASTLFPAIEKNIVKKMVAFNNQIDHEVTVEKKWGQKGGPWEFNLRD
LFRWCQLMLVDQSPGCYDPGQHVFLVYGERMRTEEDKKKVIAVFKDVFGS
NSNPYMGTRLFRITPYDVQLGYSVLSRGSCVPHPSRHPLLLLHQSFQPLE
SIMKCVQMSWMVILVGPASVGKTSLVQLLAHLTGHTLKIMAMNSAMDTTE
LLGGFEQVDLIRPWRRLLEKVEGTVRALLRDSLLISADDAEVVLRAWSHF
LLTYKPKCLGEGGKAITMEIVNKLEAVLLLMQRLNNKINSYCKAEFAKLV
EEFRSFGVKLTQLASGHSHGTFEWVDSMLVQALKSGDWLLMDNVNFCNPS
VLDRLNALLEPGGVLTISERGMIDGSTPTITPNPNFRLFLSMDPVHGDIS
RAMRNRGLEIYISGEGDASTPDNLDLKVLLHSLGLVGNSVCDILLALHTE
TRSTVVGSPTSSVSTLIQTAILIVQYLQRGLSLDRAFSEACWEVYVCSQH
SPANRKLVQALLEKHVSSLRAHETWGDSILGMGLWPDSVPSALFATEDSH
LSTVRRDGQILVYCLNRMSMKTSSWTRSQPFTLQDLEKIMQSPSPENLKF
NAVEVNTYWIDEPDVLVMAVKLLIERATNQDWMLRVKWLYHLAKNIPQGL
ESIQIHLEASAASLRNFYSHSLSGAVSNVFKILQPNTTDEFVIPLDPRWN
MQALDMIRNLMDFDPQTDQPDQLFALLESAANKTIIYLDREKRVFTEANL
VSVGSKKLRESVLRMSFEFHQDPESYHTLPHEIVVNLAAFFELCDALVLL
WVQSSQGMVSDASANEILGSLRWRDRFWTVADTVKVDAPGLALLALHWHW
VLKHLVHQIPRLLMNYEDKYYKEVQTVSEHIQNCLGSQTGGFAGIKKLQK
FLGRPFPFKDKLVVECFSQLKVLNKVLAIREQMSALGESGWQEDINRLQV
VASQWTLKKSLLQAWGLILRANILEDVSLDELKNFVHAQCLELKAKGLSL
GFLEKKHDEASSLSHPDLTSVIHLTRSVQLWPAMEYLAMLWRYKVTADFM
AQACLRRCSKNQQPQINEEISHLISFCLYHTPVTPQELRDLWSLLHHQKV
SPEEITSLWSELFNSMFMSFWSSTVTTNPEYWLMWNPLPGMQQREAPKSV
LDSTLKGPGNLNRPIFSKCCFEVLTSSWRASPWDVSGLPILSSSHVTLGE
WVERTQQLQDISSMLWTNMAISSVAEFRRTDSQLQGQVLFRHLAGLAELL
PESRRQEYMQNCEQLLLGSSQAFQHVGQTLGDMAGQEVLPKELLCQLLTS
LHHFVGEGESKRSLPEPAQRGSLWVSLGLLQIQTWLPQARFDPAVKREYK
LNYVKEELHQLQCEWKTRNLSSQLQTGRDLEDEVVVSYSHPHVRLLRQRM
DRLDNLTCHLLKKQAFRPQLPAYESLVQEIHHYVTSIAKAPAVQDLLTRL
LQALHIDGPRSAQVAQSLLKEEASWQQSHHQFRKRLSEEYTFYPDAVSPL
QASILQLQHGMRLVASELHTSLHSSMVGADRLGTLATALLAFPSVGPTFP
TYYAHADTLCSVKSEEVLRGLGKLILKRSGGKELEGKGQKACPTREQLLM
NALLYLRSHVLCKGELDQRALQLFRHVCQEIISEWDEQERIAQEKAEQES
GLYRYRSRNSRTALSEEEEEEREFRKQFPLHEKDFADILVQPTLEENKGT
SDGQEEEAGTNPALLSQNSMQAVMLIHQQLCLNFARSLWYQQTLPPHEAK
HYLSLFLSCYQTGASLVTHFYPLMGVELNDRLLGSQLLACTLSHNTLFGE
APSDLMVKPDGPYDFYQHPNVPEARQCQPVLQGFSEAVSHLLQDWPEHPA
LEQLLVVMDRIRSFPLSSPISKFLNGLEILLAKAQDWEENASRALSLRKH
LDLISQMIIRWRKLELNCWSMSLDNTMKRHTEKSTKHWFSIYQMLEKHMQ
EQTEEQEDDKQMTLMLLVSTLQAFIEGSSLGEFHVRLQMLLVFHCHVLLM
PQVEGKDSLCSVLWNLYHYYKQFFDRVQAKIVELRSPLEKELKEFVKISK
WNDVSFWSIKQSVEKTHRTLFKFMKKFEAVLSEPCRSSLVESDKEEQPDF
LPRPTDGAASELSSIQNLNRALRETLLAQPAAGQATIPEWCQGAAPSGLE
GELLRRLPKLRKRMRKMCLTFMKESPLPRLVEGLDQFTGEVISSVSELQS
LKVEPSAEKEKQRSEAKHILMQKQRALSDLFKHLAKIGLSYRKGLAWARS
KNPQEMLHLHPLDLQSALSIVSSTQEADSRLLTEISSSWDGCQKYFYRSL
ARHARLNAALATPAKEMGMGNVERCRGFSAHLMKMLVRQRRSLTTLSEQW
IILRNLLSCVQEIHSRLMGPQAYPVAFPPQDGVQQWTERLQHLAMQCQIL
LEQLSWLLQCCPSVGPAPGHGNVQVLGQPPGPCLEGPELSKGQLCGVVLD
LIPSNLSYPSPIPGSQLPSGCRMRKQDHLWQQSTTRLTEMLKTIKTVKAD
VDKIRQQSCETLFHSWKDFEVCSSALSCLSQVSVHLQGLESLFILPGMEV
EQRDSQMALVESLEYVRGEISKAMADFTTWKTHLLTSDSQGGNQMLDEGF
VEDFSEQMEIAIRAILCAIQNLEERKNEKAEENTDQASPQEDYAGFERLQ
SGHLTKLLEDDFWADVSTLHVQKIISAISELLERLKSYGEDGTAAKHLFF
SQSCSLLVRLVPVLSSYSDLVLFFLTMSLATHRSTAKLLSVLAQVFTELA
QKGFCLPKEFMEDSAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVE
DTFQKGQEKDKEDPDSKSDIKGEDNAIEMSEDFDGKMHDGELEEQEEDDE
KSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETGP
GMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKIN
EQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDN
EEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDK
AEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPA
DQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELA
GAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRK
PGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEH
IKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFK
AADVEQLKPEEIKSGTTAPLGFDEMEVEIQTVKTEEDQDPRTDKAHKETE
NEKPERSRESTIHTAHQFLMDTIFQPFLKDVNELRQELERQLEMWQPRES
GNPEEEKVAAEMWQSYLILTAPLSQRLCEELRLILEPTQAAKLKGDYRTG
KRLNIRKVIPYIASQFRKDKIWLRRTKPSKRQYQICLAIDDSSSMVDNHT
KQLAFESLAVIGNALTLLEVGQIAVCSFGESVKLLHPFHEQFSDYSGSQI
LRLCKFQQKKTKIAQFLESVANMFAAAQQLSQNISSETAQLLLVVSDGRG
LFLEGKERVLAAVQAARNANIFVIFVVLDNPSSRDSILDIKVPIFKGPGE
MPEIRSYMEEFPFPYYIILRDVNALPETLSDALRQWFELVTASDHP

## Modelni organizmi
Urađena su 24 testa na mutantnim miševima i primijećene su tri značajne abnormalnosti. Nijedan homozigotni mutantni embrion nije identificiran tokom gestacije, pa nijedan nije preživio do odvikavanja. Preostali testovi su provedeni na heterozigotnim mutantnim odraslim miševima; ženke su imale povećanu osjetljivost na bakterijsku infekciju.

## Reference
## Dopunska literatura 
Kategorija:Mišji mutirani geni
Kategorija:Geni na hromosomu 6
Kategorija:Ljudski proteini
Kategorija:Proteomika