UBR4

**E3 ubikvitin-protein ligaza UBR4** jest enzim koji je kod ljudi kodiran genom **UBR4** sa hromosoma 1.

## Aminokiselinska sekvenca
Dužina polipeptidnog lanca je  5.183 aminokiselina, a molekulska težina  573.841 Da.

1020304050
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELP
QLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSV
AAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIIT
FTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSV
FNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQEL
GGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFH
SLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAIL
HVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGG
EHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSR
TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGW
ETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQR
QRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETIS
PSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGL
ASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKG
SSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIH
PQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGVVP
SETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRF
VPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNS
RRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDS
VACDVLFSKLVKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQ
YYFLILWRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSY
VNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVEIVEEYFARQISS
FCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHK
SSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAA
VLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNA
FANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIV
WSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARV
YEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEF
FSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLC
GSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIV
RENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQG
AGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIM
SYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAE
DSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHK
DHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPR
ISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQ
NQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEK
AVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPV
PFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGN
FIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVT
FLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLK
DSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPIN
IKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQ
EIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTS
YWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTD
VEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMT
GMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKK
LNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICP
SNLNQSNGTGDSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKER
NKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSK
AVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQME
TEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGL
THIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQA
LIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGG
HIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGF
PPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSS
SSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGS
AVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGD
GSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYM
QVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNE
VHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLH
VLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAA
DVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMI
QQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIF
LRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSV
LYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSA
PVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLN
KFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDL
MWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQ
NHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSI
KVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQ
AIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYEN
YQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLC
NACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVY
HQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLA
QEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPT
FTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHIL
VSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGK
VSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMA
VNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCN
EIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEK
YVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVE
ALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYL
AARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVE
VESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTT
GTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFF
VTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALL
EDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGD
ATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQ
GRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQES
KDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQ
INSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDED
HSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIP
SAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHK
LEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMR
QKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPT
KVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARG
REEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQR
EPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYV
LNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQ
WRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALV
DLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFM
PVETFSEFLDVAGLLSEITDPESFLKDLLNSVP

## Reference
## Dopunska literatura
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## Vanjski linkovi
Kategorija:Geni na hromosomu 1
Kategorija:Enzimi
Kategorija:Ljudski proteini
Kategorija:Proteomika