TRANK1

**Protein 1 sa tetratrikopeptidnim i ankirinskim ponavljanjem** jest protein koji je kod ljudi kodiran genom **TRANK1** sa hromosoma 3.

## Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 2.925 aminokiselina, а molekulska težina  Da. 336 221

1020304050
MWDPRAARVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVK
GYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMS
SDSIVLQSFLPCFDHIFTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKD
RLPRNIHVPELSLKSLFEKYVFIGLYEKMEQVPKLVQWLISIGASVETIG
PYPLHALMRLCIQARENHLFRWLMDHKPEWKGRINQKDGDGCTVLHVVAA
HSPGYLVKRQTEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKI
NSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVLEQLVKYMNSGNRLLHK
NFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLLEKQRWPEV
LLLLTRKVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCL
IDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDT
PLHAALHIFLEIKADIGFSFLSHLLDLFWSNPTEFDYLNPNVQDSNGNTL
MHILFQKGMLKRVKKLLDLLVKFDINFNLKNKEGKDARHRIKKNDSLLLA
WNKALMENRRRSRQDSAAHLGKLSKSTAPGHTSQLKSQGSFKSVPCGATA
RTLPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLIQQVE
VDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVG
LGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLK
KLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLD
KGARMLWELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDI
VLDHCKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPR
CYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFSTNMAFNILNDT
TATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKF
HVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDS
IEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIF
VTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFV
TSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEE
AEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPA
LIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSL
FSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQ
AELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTID
KQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDS
GLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKE
KIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPTS
TDSREENRPLVEVPLDKPGSSQGRSLMVNPEMYKLLNGELKQLYTAITRA
RVNLWIFDENREKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPA
EWIAQGDYYAKHQCWKVAAKCYQKGGAFEKEKLALAHDTALSMKSKKVSP
KEKQLEYLELAKTYLECKEPTLSLKCLSYAKEFQLSAQLCERLGKIRDAA
YFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEELFEEAAIAVEKYEEMLK
TKTLPISKLSYSASQFYLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLK
SRKRLAEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLG
AARLNVARDSDIEHTKDILREALDICYQTGQLSGIAEAHFLQGVILRDFQ
KLRDAFFKFDTLNHSAGVVEALYEAASQCEAEPEKILGLAPGGLEILLSL
VRALKRVTNNAEKEMVKSCFEFFGISQVDAKYCQIAQNDPGPILRIIFDL
DLNLREKKTKDHFLIMTDQVKLALNKHLLGRLCQITRSLLGKTYRGVCMR
FIVGLKCEDENCEHFHRPLRRCEAKCLVQSKMNLVAINGLLLEAKKVFPK
ILAEELKEIDYILSTDMYGLCKSILDVLFPKHFHQRVLSENPMACKEILK
PNYKSFRFYRFALKEYIHFLFENESARNRRESTDLWLSAMQAFLLSSNYP
EEFEKLLHQEEDNYNRELKALESEKDERGRGRGSRIKGIEGKFGMLAPNR
DDENMDKTHLCFIRLLENCIDQFYVYRNPEDYKRLFFRFMNVLIKRCKEP
LIPSIGNTVALLEFQFIHCGVVLARLWKNVILCLPKSYIALLHYWEFLFS
KKDKELGDVFSIIQEYKPKDVTRAIQDFRFHLSYLAKVLCGYENVNFNVL
LDAFSEIDYVVSGEAERTLVLCLVMLVNAEEILQPYCKPLLYRHFREIES
RLQLMSMDCPGQVPERLLKVVKRVLVAVNVKSVAEALQDLLFERDEEYLM
DCDWRWDPVHTKGSIVRGLYYEEVRLNRLLCLDPVDYFAEPECEFGQDEM
DELALEDRDHVLATILSQKQRKASIQRKLRRACLVVSLCISWRRRVGTQM
ERVREEAREPRAGNFKKADVDRTQCDLCGVKFTRGPENYFSPSKAFEGAA
SEVAVLSRAELEREECQERNSESYEQHIHLEHHQRQQVAYQKYSEFFHEK
VDPAIDEGKLVVQDIEQSVWIHSHVGSKEHSHMLQKVQEHIKRVSDMVED
LYRRKAWAGAEEAMTRLVNILILSVRDARDWLMKTETRLKKEGIVQEDDY
ENEVEDFGELRPRRRSRKCGKQRKY

## Klinički značaj
Studijom asocijacije koja obuhvata čitav genom, TRANK1 je povezan sa bipolarnim poremećajem.

## Reference 
## Dopunska literatura
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Kategorija:Geni na hromosomu 3
Kategorija:Ljudski proteini
Kategorija:Proteomika