Stefan Offermanns

** Stefan Offermanns** () — 1964-cü ildə Almaniyanın Berlin şəhərində anadan olmuşdur. S. Offermans Berlin və Londonda tibb təhsili başa vurduqdan sonra Azad Berlin Universitetində doktorluq dərəcəsi almışdır (1991). 1994–1997-ci illərdə Kaliforniya Texnologiya İnstitutunda doktoranturadan sonrakı təqaüd proqramını bitirdikdən sonra Azad Berlin Universitetində Heyzenberq təqaüdçüsü olmuşdur (1998).

2000–2009-cu illərdə Heydelberq Universitetinin Farmakologiya İnstitutunun professoru və direktoru vəzifəsini icra edən alim, 2008-ci ildən etibarən Maks Plank Ürək və Ağciyər Tədqiqatları İnstitutunun direktoru və tədqiqatçısıdır. S. Offermans 2009-cu ildən Frankfurt Höte Universitetinin Farmakologiya bölməsinin professorudur.

## Elmi əsərləri
* Al Hamwi G, Alnouri MW, Verdonck S, Leonczak P, Chaki S, Frischbutter S, Kolkhir P, Matthey M, Kopp C, Bednarski M, Riedel YK, Marx D, Clemens S, Namasivayam V, Gattner S, Thimm D, Sylvester K, Wolf K, Kremer AE, De Jonghe S, Wenzel D, Kotańska M, Ali H, Herdewijn P, Müller CE. (2025) Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models. Signal Transduct Target Ther. 10, 128.
* Chen X, Shao J, Brandenburger I, Qian W, Hahnefeld L, Bonnavion R, Cho H, Wang S, Hidalgo J, Wettschureck N, Geisslinger G, Gurke R, Wang Z, Offermanns S. (2025) FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes. Nat Commun. 16, 3422.
* Cho H, Lai CC, Bonnavion R, Alnouri MW, Wang S, Roquid KA, Kawase H, Campos D, Chen M, Weinstein LS, Martínez A, Looso M, Sanda M, Offermanns S. (2025) Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Science. 387, 674–682.
* Dutzmann J, Daniel JM, Korte L, Kloss FJ, Knöpp K, Kalies K, Croce KJ, Herbst TJ, Huibregtse B, Vogt FJ, Offermanns S, Bauersachs J, Sedding DG. (2025) Adventitial Fibroblasts Release Interleukin 6 After Vascular Injury and Induce Smooth Muscle Cell Proliferation and Neointima Formation. J. Am. Heart Assoc. 14, e040143.
* Alnouri MW, Roquid KA, Bonnavion R, Cho H, Heering J, Kwon J, Jäger Y, Wang S, Günther S, Wettschureck N, Geisslinger G, Gurke R, Müller CE, Proschak E, Offermanns S. (2024) SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. Proc Natl Acad Sci U S A. 121, e2407130121.
* Dörner PJ, Anandakumar H, Röwekamp I, Fiocca Vernengo F, Millet Pascual-Leone B, Krzanowski M, Sellmaier J, Brüning U, Fritsche-Guenther R, Pfannkuch L, Kurth F, Milek M, Igbokwe V, Löber U, Gutbier B, Holstein M, Heinz GA, Mashreghi MF, Schulte LN, Klatt AB, Caesar S, Wienhold SM, Offermanns S, Mack M, Witzenrath M, Jordan S, Beule D, Kirwan JA, Forslund SK, Wilck N, Bartolomaeus H, Heimesaat MM, Opitz B. (2024) Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung. Nat Commun. 15, 2788.
* Hernandez-Olmos V, Heering J, Marinescu B, Schermeng T, Ivanov VV, Moroz YS, Nevermann S, Mathes M, Ehrler JHM, Alnouri MW, Wolf M, Haydo AS, Schmachtel T, Zaliani A, Höfner G, Kaiser A, Schubert-Zsilavecz M, Beck-Sickinger AG, Offermanns S, Gribbon P, Rieger MA, Merk D, Sisignano M, Steinhilber D, Proschak E. (2024) Development of a Potent and Selective G2A (GPR132) Agonist. J Med Chem. 67, 10567–10588.
* Hunt JE, Christiansen CB, Yassin M, Hartmann B, Offermanns S, Dragsted LO, Holst JJ, Kissow H. (2024) The Severity of DSS-Induced Colitis Is Independent of the SCFA-FFAR2/3-GLP-1 Pathway Despite SCFAs Inducing GLP-1 Secretion via FFAR2/3. Metabolites 14, 395.
* Keshavarz M, Ruppert AL, Meiners M, Poharkar K, Liu S, Mahmoud W, Winterberg S, Hartmann P, Mermer P, Perniss A, Offermanns S, Kummer W, Schütz B. (2024) Bitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors. Sci. Rep. 14, 18447.
* Alexander SPH, and collaborators. (2023) The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 180 Suppl 2, S23-S144.
* Alexander SPH, and collaborators. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. Br J Pharmacol. 180 Suppl 2, S145-S222.
* Balla H, Borsodi K, Őrsy P, Horváth B, Molnár PJ, Lénárt Á, Kosztelnik M, Ruisanchez É, Wess J, Offermanns S, Nyirády P, Benyó Z. (2023) Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions. Am J Physiol Renal Physiol. 325, F618-F628.
* Bonnavion R, Liu S, Kawase H, Roquid KA, Offermanns S. (2023) Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5). Front Pharmacol. 14, 1297596.
* Cowan R, Trokter M, Oleksy A, Fedorova M, Sawmynaden K, Worzfeld T, Offermanns S, Matthews D, Carr MD, Hall G. (2023) Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling. J Biol Chem. 299, 104740.
* Bolik J, Krause F, Stevanovic M, Gandraß M, Thomsen I, Schacht SS, Rieser E, Müller M, Schumacher N, Fritsch J, Wichert R, Galun E, Bergmann J, Röder C, Schafmayer C, Egberts JH, Becker-Pauly C, Saftig P, Lucius R, Schneider-Brachert W, Barikbin R, Adam D, Voss M, Hitzl W, Krüger A, Strilic B, Sagi I, Walczak H, Rose-John S, Schmidt-Arras D. (2022) Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis. J Exp Med. 219, e20201039.
* Borsodi K, Balla H, Molnár PJ, Lénárt Á, Kenessey I, Horváth A, Keszthelyi A, Romics M, Majoros A, Nyirády P, Offermanns S, Benyó Z. (2022) Signaling Pathways Mediating Bradykinin-Induced Contraction in Murine and Human Detrusor Muscle. Front Med. (Lausanne) 8, 745638.
* Briquet M, Rocher AB, Alessandri M, Rosenberg N, de Castro Abrantes H, Wellbourne-Wood J, Schmuziger C, Ginet V, Puyal J, Pralong E, Daniel RT, Offermanns S, Chatton JY. (2022) Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue. J Cereb Blood Flow Metab., 42, 1650–1665.
* Gogiraju R, Gachkar S, Velmeden D, Bochenek ML, Zifkos K, Hubert A, Münzel T, Offermanns S, Schäfer K. (2022) Protein Tyrosine Phosphatase 1B Deficiency in Vascular Smooth Muscle Cells Promotes Perivascular Fibrosis following Arterial Injury. Thromb Haemost. 122, 1814–1826.
* Gupta R, Wang M, Ma Y, Offermanns S, Whim MD. (2022) The β-Hydroxybutyrate-GPR109A Receptor Regulates Fasting-induced Plasticity in the Mouse Adrenal Medulla. Endocrinology 163, bqac077.

## İstinadlar