Maria Manuel Dias da Mota

**Maria Manuel Dias da Mota**  ye una científica portuguesa.

En 1992, na Universidá de Porto, llogró una llicenciatura en bioloxía, realizando la so maestría en inmunoloxía en 1994, y el doctoráu en parasitoloxía molecular en 1998, defendiendo la so tesis *Parasitoloxía Molecular* pola University College de Londres, Reinu Xuníu. Realiza actividaes académiques nel Institutu de Medicina Molecular, (IMM), como investigadora principal na Unidá de Malaria. Y dende 2005, ye profesora convidada na Facultá de Medicina de la Universidá de Lisboa.

## Delles publicaciones
* . 2012. *A novel Carbon Monoxide-Releasing Molecule (CO-RM) fully protects mice from Severe Malaria*. Antimicrob Agents Chemother. 56 (3): 1281-90

* . 2012. *Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug*. J Infect Dis. 205(8): 1278-86

* . 2011. *Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Anti-Malarial Strategy*. Antimicrob Agents Chemother

* . 2011. *Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio*. PLoS Pathog 7(5):e1002046

* . 2011. *Host-mediated control of Malaria Superinfection*. Nature Medicine 17 (6): 732-7

* . 2011. *Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing*. Malar J. 10:74

* . 2011. Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host*. Malar J. 10(1):71

* . 2011. *Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle*. Antimicrob Agents Chemother 55(6): 2824-30

* . 2011. *The relevance of non-human primate and rodent malaria models for humans*. Malar J. 10(1): 23

* . 2011. *Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure-Antimalarial Activity Relationships and Mechanistic Studies*. J Med Chem. 54(3): 734

* . 2010. *Accumulation of Plasmodium-infected red blood cells in the brain is crucial for the development of cerebral malaria in mice*. Infect Immun. 78(9): 4033-9

* . 2010. *Crystal Structure of Arginase from Plasmodium falciparum and Implications for l-Arginine Depletion in Malarial Infection*. Biochemistry 49(26): 5600-8

* . 2010. *VEGF promotes malaria-associated acute lung injury in mice*. [[PLOS Pathogens|PLoS Pathog]] 6(5): e1000916

* . 2010. *Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility*. Cell Microbiol. 2(4): 506

* . 2009. *Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging*. PLoS One 4(11): e7881

* . 2008. *Interactions of the malaria parasite and its mammalian host*. Curr Opin Microbiol. 11 (4): 352-9

* . 2008. *New pieces for the malaria liver stage puzzle: where will they fit?* Cell Host Microbe 14;3 (2): 63-5

* ------------. 2006. *Be in motion*. Mol Microbiol. 60 (6): 1327-8

* ------------, . 2004. *Targeting Plasmodium host cells: survival within hepatocytes*. Trends Mol Med. 10: 487-92

* ------------, . 2004. *Migration through host cells: the first steps of Plasmodium sporozoites in the mammalian host''. Cell Microbiol 6: 1113-8

## Patentes
* Métodu pa la prevención de la infeición de la malaria n'humanos por antagonistes del factor de crecedera de hepatocitos. Sudáfrica: patente Non. 2005/ 08178. Sobre la base de la International PCT Publication Nᵘ WO2004/080420, African Reg. Ind. Prop. Org. – Application Nᵘ AP/P/2005/003411, Brasil – Aplicación Nᵘ PI040826 8-0, China – publicación Nᵘ CN1809382A, Europa – publicación Nᵘ 601378, Hong Kong – publicación Nᵘ 1093903A, Xapón – aplicación Nᵘ 2006-507105, EE. XX.- publicación Nᵘ US 2004-0185050 A1

* Usu de inhibidores de proteínes scavenger receptores pal tratamientu d'enfermedaes infeicioses (WO/2007/101710), aplicación internacional Nᵘ PCT/EP2007/002110, fases nacionales inicializadas en EE. XX., XE, Canadá, China n'ochobre de 2008

* Usu de inhibidores de quinasas de receptores pal tratamientu d'enfermedaes infeicioses, aplicación provisional de EE. XX. Nᵘ 61/110,217, archiváu 31 d'ochobre de 2008

## Honores
* Presidenta de l'Associação Viver a Ciência.
* Beca año 2012 del FCT

## Ver tamién
* Malaria

## Fuentes

## Referencies

## Enllaces esternos

* Curriculum vitae
* Unidá de Malaria del IMM