Title: Regulation of the proteolytic processing and function of Amyloid Precursor Protein by candidate ligands
Description: Despite intense interest in the proteolysis of Amyloid Precursor Protein (APP) in Alzheimer's disease (AD), how the normal processing and function of this type I receptor-like glycoprotein is regulated remains ill-defined. APP is reported to function in neurodevelopment, including migration of neuronal precursor cells into the cortical plate. In recent years, several candidate ligands for APP, including F-spondin, Reelin, â1 Integrin, Contactins, and Lingo-1 have been reported. However, a cognate ligand for APP that regulates its function or processing has yet to be widely confirmed in multiple laboratories.