Title: Protein Quality Control in Neurodegenerative Diseases
            
                Research and Perspectives in Alzheimers Disease
Description: The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
Subjects: Nervous system, Degeneration, Neurodegenerative Diseases, Etiology, Pathology, Protein Conformation, Proteome, Metabolism, Proteostasis Deficiencies, Nervous system, degeneration and regeneration, Proteins, Medicine, Neurosciences, Neurochemistry