Title: Identification of microRNA Biogenesis Regulators and Activity Modulators
Description: MicroRNAs play a key role in post-transcriptional gene regulation. They regulate target gene expression with mRNA degradation or translation repression. Each miRNA is estimated to regulate dozens of genes in human, and dysregulation of miRNA leads to various diseases, such as cancer, heart disease and depression. Therefore, it is critical to understand the mechanism of miRNA biogenesis and targeting. This work integrated gene and miRNA expression profile from various cancer projects to screen for potential miRNA biogenesis regulators and activity modulators. In this analysis, we identified several genes that regulate miRNA pathway and found their association with tumor progression and clinical outcome.