Title: Genetic and Epigenetic Foundations, Molecular Basis, and Mechanistic Pathways of Chronic Inflammation-Driven Tumorigenesis
Subtitle: Targeting NF-κB and STAT3 Signaling
Description: A comprehensive overview of the molecular and cellular mechanisms that link chronic inflammation to cancer. It examines how chronic inflammation promotes tumor development by driving genetic mutations, epigenetic changes, and the disruption of critical cellular pathways. Key signaling networks are explored in detail, revealing their central roles in cancer progression, immune suppression, and therapy resistance.
 
Focusing on the interplay between inflammation and the tumor microenvironment, this text discusses how reactive oxygen species, DNA damage, and epigenetic reprogramming work together to create a permissive environment for malignancy. Insights into the involvement of immune modulation and the microbiome further underscore the complexity of inflammation-driven cancers.​
Subjects: Inflammation, Oncology, Immunology, Molecular biology, Genetics, Genomics, Genetics & Genomics, Human genetics, Tumors, Biological Tumor Markers