Title: Protein-metal interactions
Description: Metal ions and proteins are ubiquitous. Therefore, not surprisingly, new protein-metal interactions continue to be discovered, and their importance is increasingly recognized in both physical and life sciences. Because the subject matter is so broad and affects so many disciplines, in organizing this Symposium, I sought participation of speakers with the broadest possible range of interests. Twenty-two accepted my invitation. To supplement the verbal presentations, the Proceedings include five closely related invited contributions. The ideas expressed are those of the various authors and are not necessarily approved or rejected by any agency of the United States Government. No official recommendation concerning the subject matter or products discussed is implied in this book. This book encompasses many aspects of this multifaceted field.

Topics covered represent biochemical, immunochemical, bioorganic, biophysical, metabolic, nutritional, medical, physiological, toxicological, environmental, textile, and analytical interests. The discoveries and developments in any of these areas inevitably illumine others. I feel that a main objective of this Symposium, bringing together scientists with widely varied experiences yet with common interests in protein-metal interactions, so that new understanding and new ideas would result has been realized. I hope that the reader enjoys and benefits from reading about the fascinating interactions of metal ions and proteins as much as I did.

Although an adequate summary of the Symposium is not possible in a brief preface, I wish to express particular interest in the ideas reported by Professor Frieden: that the relative occurrence and participation of the various metals as essential elements in enzyme action and other life processes is an adaptive relationship to their relative abundance in the ocean. Undoubtedly, this adaptation is a continuing process. A more immediate practical concern voiced by D. K. Darrow and H. A. Schroeder that has received widespread publicity and debate is that children are highly susceptible to lead poisoning and that their exposure to lead nowadays comes mainly from automobile exhaust. Of the invited contributions supplementing the Symposium, the paper by J. T. MacGregor and T. W. Clarkson deserves special mention. Dr. MacGregor collaborated with Dr.

Clarkson, his former major professor, in this thorough review while the latter was out of the country dealing directly with an episode of mercury poisoning described in their paper. I believe their critical compilation of tissue distribution and toxicity of mercury compounds will greatly benefit the medical and other scientific communities in dealing with this useful but dangerous element. to lead poisoning and that their exposure to lead nowadays comes mainly from automobile exhaust. Of the invited contributions supplementing the Symposium, the paper by J. T. MacGregor and T. W. Clarkson deserves special mention. Dr. MacGregor collaborated with Dr. Clarkson, his former major professor, in this thorough review while the latter was out of the country dealing directly with an episode of mercury poisoning described in their paper.

I believe their critical compilation of tissue distribution and toxicity of mercury compounds will greatly benefit the medical and other scientific communities in dealing with this useful but dangerous element.
Subjects: Proteins, Metals, Physiological effect, Metals in the body, Congresses, Metabolism, Métaux dans l'organisme, Congrès, Métaux, Effets physiologiques, Protéines, Métabolisme, 1973-08-29