CNS cancer
Subtitle: models, markers, prognostic factors, targets, and therapeutic approaches
By: Erwin G. Van Meir, editor
Series: Cancer drug discovery and development; Cancer drug discovery and development
Publisher: Humana Press
Published: 2009
Place of publication: Central nervous system cancer; Dordrecht; New York
Language: eng
Number of pages: 1284
ISBN-13: 9781603275521; 9781603275538
Notes: Includes bibliographical references and index.
Table of contents: title: Part I. Animal Models for central nervous tumors; title: Modeling gliomas using PDGF-expressing retroviruses; title: Modeling brain tumors using avian retroviral gene transfer; title: Using neurofibromatosis type 1 mouse models to understand human pediatric low-grade gliomas; title: Transgenic mouse models of CNS tumors: using genetically engineered murine models to study the role of p21 Ras in glioblastoma multiforme; title: PTEN-deficient mouse models for high-grade astrocytomas; title: The Nfl-/+; Trp53-/+cis mouse model of anaplastic astrocytoma and secondary glioblastoma : dissecting genetic susceptibility to brain cancer; title: Modeling astrocytomas in a family of inducible genetically engineered mice : implications for preclinical cancer drug development; title: Human brain tumor cell and tumor tissue transplantation models; title: Transformed human brain cells in culture as a model for brain tumors; title: Rat glioma models for preclinical evaluation of novel therapeutic and diagnostic modalities; title: Neuro-oncogenesis induced by nitroso compounds in rodents and strain-specific genetic modifiers of predisposition; title: The murine GL261 glioma experimental model to assess novel brain tumor treatments; title: Spontaneous occurrence of brain tumors in animals: opportunities as preclinical model systems; title: Part II. Prognostic factors and biomarkers; title: p53 pathway alterations in brain tumors; title: The PTEN/P13 kinase pathway in human glioma; title: Value of 1p/19q and other LOH markers for brain tumor diagnosis, prognosis, and therapy; title: Discovery of genetic markers for brain tumors by comparative genomic hybridization; title: Genomic identification of significant targets in brain cancer; title: Oncomodulatory role of the human cytomegalovirus in glioblastoma; title: Aberrant EGFR signaling in glioma; title: Mechanisms of brain tumor angiogenesis; title: Vaso-occlusive mechanisms that intiate hypoxia and necrosis in glioblastoma: the role of thrombosis and tissue factor; title: Transcription profiling of brain tumors: tumor biology and treatment stratification; title: Proteomic profiling of human brain tumors; title: Proteomic discovery of biomarkers in the cerebrospinal fluid of brain tumor patients; title: Epigenetic profiling of gliomas; title: Micronase in the central nervous system and potential roles of RNA interference in brain tumors; title: Of Escherichia coli and man : understanding glioma resistance to temozolomide therapy; title: Brain tumor stem cell markers; title: Part III. Therapeutic targets and targeting approaches; title: Clinical agents for the targeting of brain tumor vasculature; title: Bone marrow-derived cells in GBM neovascularization; title: Vascular targeting of brain tumors; title: bridging the gap with phage display; title: Impact of the blood-brain barrier on brain tumor imaging and therapy; title: Targeting CXCR4 in brain tumors; title: Molecular targeting of IL-13R[alpha]2 and EphA2 receptor in GBM; title: Molecular targets for antibody-mediated immunotherapy of malignant glioma; title: Stat3 oncogenic signaling in glioblastoma multiforme; title: Inhibition of Ras signaling for brain tumor therapy; title: HGF/c-Met signaling and targeted therapeutics in brain tumors; title: Combinatorial therapeutic strategies for blocking kinase pathways in brain tumors; title: Targeting the TRAIL apoptotic pathways for glioblastoma therapies; title: The NF-[kappa]B signaling pathway in GBMs : implications for apoptotic and inflammatory responses and exploitation for therapy; title: Targeting endoplasmic reticulum stress for malignant glioma therapy; title: Brain cancer stem cells as targets of novel therapies; title: The use of retinoids as differentiation agents against medulloblastoma; title: Herpes simplex virus 1 (HSV-1) for glioblastoma multiforme therapy; title: The development of targeted cancer gene-therapy adenoviruses for high-grade glioma treatment; title: Harnessing T-cell immunity to target brain tumors; title: Glioma invasion : mechanisms and therapeutic challenges.