Mass spectrometry for drug discovery and drug development
By: edited by Walter A. Korfmacher
Publisher: Wiley
Published: 2013
Place of publication: Hoboken, N.J
Language: eng
Number of pages: 461
ISBN-13: 9780470942383
Subjects: Pharmaceutical Preparations; Peptides; Methods; Mass Spectrometry; Drug Discovery; Proteins; Analysis
Notes: Includes bibliographical references and index.
Table of contents: title: 1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner; title: 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang; title: 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia; title: 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou; title: 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash; title: 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky; title: 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak; title: 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion; title: 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik; title: 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli; title: 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer; title: 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury; title: 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan; title: 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily; title: 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens.