Fragment-based drug discovery
Subtitle: a practical approach
By: [edited by] Edward Zartler and Michael Shapiro.
Contributors: Zartler, Edward.; Shapiro, Michael
Publisher: John Wiley & Sons
Published: 2008
Place of publication: Hoboken, N.J
Language: eng
ISBN-13: 9780470058138
Subjects: Drug development; Drugs -- Design; Ligands (Biochemistry); Drug Design; Ligands; Magnetic Resonance Spectroscopy -- methods
Notes: Includes bibliographical references and index.
Table of contents: title: Introduction to fragment based drug discovery / Tim Mitchell and Mike Cherry; title: Building the perfect beast : designing a fragment process to fit your needs / Edward Zartler and Michael Shapiro; title: Assembling a fragment library / Mark Brewer ... [et al.]; title: The practical aspects of using NMR in fragment based screening / Johan Schultz; title: Application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses / William J. Metzler ... [et al.]; title: Target immobilized NMR screening : validation and extension to membrane proteins / Virginie Früh, Robert J. Heetebrij and Gregg Siegal; title: In situ fragment-based medicinal chemistry : screening by mass spectrometry / Sally-Ann Poulsen and Gary H. Kruppa; title: Computational approaches to fragment and substructure discovery and evaluation / Eelke van der Horst and Adriaan P. IJzerman; title: In silico design chapter / Bradley Feuston ... [et al.]; title: Fragment-based lead discovery using covalent capture methods / Stig K. Hansen & Daniel A. Erlanson; title: Identification of high affinity beta-secretase inhibitors using fragment-based lead generation / Jeffrey S. Albert and Philip D. Edwards.