Dissecting and Targeting the PUMA and OLIG2 Control Points of Tumors of Neuroectodermal Origin with Stapled Peptides
Contributors: Walensky, Loren D.; DeCaprio, James; Danial, Nika; Shoulders, Matthew
Published: 2013
Language: eng
Description: Tumors of neuroectodermal origin are among the most aggressive and treatment-refractory forms of human cancer. While such tumors arise from a variety of defects, two key targets are the transcription factors p53 and OLIG2. We have developed stabilized peptides to study and target deregulated p53 and OLIG2 pathways in neuroectodermal cancers.
Notes: Keywords: Apoptosis, OLIG2, PUMA, Stapled peptides.

Thesis Ph.D. Harvard University 2013