Antibodies in Vaccine Protection against SIV and HIV-1 Infection
Contributors: Evans, David T.; Farzan, Michael; Alter, Galit; Luzuriaga, Katherine; Gabuzda, Dana
Published: 2012
Language: eng
Description: The properties of human immunodeficiency virus type 1 (HIV-1) and its simian counterpart SIV that enable persistent replication in the face of robust cellular, antibody, and innate immune responses have complicated efforts to develop a safe and effective vaccine. Vaccine protection against HIV-1 infection may require a combination of immune mechanisms. However, the types of immune responses that can be induced by vaccination to prevent HIV-1 infection remain unclear.
Notes: Keywords: ADCC, antibody, assay, Live-attenuated, neutralizing, RV144.

Thesis Ph.D. Harvard University 2012