Genomic approaches to dissect innate immune pathways
Contributors: Hacohen, Nir; Haining, Nicholas; Notarangelo, Luigi D.; Pillai, Shiv; Kim, Dennis H.
Published: 2013
Language: eng
Description: The innate immune system is of central importance to the early containment of infection. When receptors of innate immunity recognize molecular patterns on pathogens, they initiate an immediate immune response by inducing the expression of cytokines and other host defense genes. Altered expression or function of the receptors, the molecules that mediate the signal transduction cascade, or the cytokines themselves can predispose individuals to infectious or autoimmune diseases. Here we used genomic approaches to uncover novel components underlying the innate immune response to cytosolic DNA and to characterize variation in the innate immune responses of human dendritic cells to bacterial and viral ligands.
Notes: Keywords: DNA sensing, eQTL, Innate immunity, Proteomics, RNAi screening, TLR.

Thesis Ph.D. Harvard University 2013