Discovering Novel Feedback and Crosstalk Mechanisms in Cellular Signaling Pathways
Contributors: Blenis, John; Toker, Alex; Brugge, Joan; Thomas, Sheila; Zang, Mengwei
Published: 2013
Language: eng
Description: Multiple signaling pathways control cellular response to environmental cues such as nutrients, growth factors and stress. Interpretation of these cues requires coordinated regulation of intracellular signaling pathways. Our attempt to understand how cells coordinate different signaling pathways led to the discovery of two crosstalk mechanisms between different signaling cascades.
Notes: Keywords: AKT, Crosstalk, Feedback, MAPK, Signaling.

Thesis Ph.D. Harvard University 2013