Molecular chronobiology of myocardial hypertrophy and the chronotherapeutic effects of captopril.
Published: 2006
Language: eng
Number of pages: 115
ISBN-13: 9780494213827
Description: Molecular and physiologic processes follow a diurnal pattern to meet the differing demands of the organism. We have shown that >10% of cardiovascular (CV) genes express diurnal rhythmicity and in compensated heart disease there is conservation of rhythms; this may have important implications for CV function. We hypothesized the efficacy of drug therapy in CV disease may also exhibit a diurnal rhythm. We investigated the diurnal efficacy of captopril (ACEi) in cardiac remodelling, by using the transverse aorta constriction (TAC) murine model of pressure overload induced hypertrophy, and administered captopril(15mg/kg)/placebo I.P. to TAC and sham mice for 8wks starting 1 wk post-surgery:1h after lights-on (AM) or 1h before lights-off (PM) (12L:12Dcycle). The effect of time of treatment on cardiac gene expression, structure and function was investigated. We showed captopril given when the mice normally slept (AM) significantly improved CV function, reversed adverse remodelling and effectively targeted the underlying molecular processes.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1402.

Thesis (M.Sc.)--University of Toronto, 2006.

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