Genomics of pattern recognition receptors
Subtitle: applications in oncology and cardiovascular diseases
By: Anton G. Kutikhin, Arsenij E. Yuzhalin
Contributors: Yuzhalin, Arseniy E., author
Publisher: Springer
Published: 2013
Place of publication: Basel
Language: eng
Number of pages: 185
ISBN-13: 9783034806879; 9783034806886
Subjects: Cell receptors; Genetics; Genomic Structural Variation; Pattern Recognition Receptors; Cardiovascular Diseases; Neoplasms; Genetik; Kardiovaskuläre Krankheit; Genomik; Humangenetik; Onkologie
Description: This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.--
Notes: Includes bibliographical references and index.
Table of contents: title: The Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation; title: Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword; title: Structural Genomic Variation in Toll-Like Receptor 4 and Cancer; title: Structural Genomic Variation in Other Toll-like Receptors and Cancer; title: Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer; title: Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer; title: Structural Genomic Variation in NOD-Like Receptors and Cancer; title: Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases; title: Hot Spots In the Field: Where Should We Go.