Nuclear Organization in Development and Disease
Subtitle: Novartis Foundation Symposium (Novartis Foundation Symposia)
Edition: 1 edition
Publisher: Wiley
Published: March 11, 2005
Language: eng
Format: Hardcover
Number of pages: 300
ISBN-13: 9780470093733
Subjects: Cellular biology; Plant pathology & diseases; Science; Science/Mathematics; Life Sciences - Cytology; Science / Biochemistry; Life Sciences - Biochemistry; Abnormalities; Cell nuclei; Congresses; Developmental cytology
Description: This book draws together contributions from scientists who are studying, from different perspectives, the nine human diseases that have been linked to mutations in genes encoding components of the nuclear envelope: cell and developmental biologists, structural biologists, geneticists and clinical scientists. Topics include how nuclear structure and location within a nucleus affect gene expression, chromatin organization and cell differentiation; the nature of the interactions between the nuclear envelope and the cytoskeleton; and the extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression, and whether disruption of such communication might underlie the disease processes.