Antitargets and Drug Safety
Series: Methods and principles in medicinal chemistry ; v. 66
Publisher: Wiley-VCH
Published: 2015
Place of publication: Weinheim, Germany
Language: eng
Format: E-book
ISBN-13: 9783527673643
Table of contents: title: General Concept for Target-based Safety Assessment.; title: Side Effects of Marketed Drugs: The Utility and Pitfalls of Pharmacovigilance / Steven Whitebread, Mateusz Maciejewski, Alexander Fekete, Eugen Lounkine, László Urbán; title: Prediction of Drug Side Effects / Michael J Keiser; title: Translational Value of Preclinical Safety Assessment: System Organ Class (SOC) Representation of Off-Targets / Mateusz Maciejewski, Eugen Lounkine, Andreas Hartmann, Steven Whitebread, László Urbán; title: Pathological Conditions Associated with the Disturbance of the 5-HT System / Daniel Hoyer; title: Hepatic Side Effects.; title: Drug-Induced Liver Injury: Clinical and Diagnostic Aspects / John R Senior; title: Mechanistic Safety Biomarkers for Drug-Induced Liver Injury / Daniel J Antoine; title: Models for the Prediction of Drug-Induced Liver Injury in Lead Discovery / Frederic Moulin, Oliver Flint; title: Transporters in the Liver / Bruno Stieger, Gerd A Kullak-Ublick; title: Mechanistic Modeling of Drug-Induced Liver Injury (DILI) / Kyunghee Yang, Jeffrey L Woodhead, Lisl K Shoda, Yuching Yang, Paul B Watkins, Kim LR Brouwer, Brett A Howell, Scott Q Siler; title: Cardiovascular Side Effects.; title: Functional Cardiac Safety Evaluation of Novel Therapeutics / Jean-Pierre Valentin, Brian Guth, Robert L Hamlin, Pierre Lainée, Dusty Sarazan, Matt Skinner; title: Safety Aspects of the Ca1.2 Channel / Berengere Dumotier, Martin Traebert; title: Cardiac Sodium Current (Na1.5) / Gary Gintant; title: Circulating Biomarkers for Drug-Induced Cardiotoxicity: Reverse Translation from Patients to Nonclinical Species / Gül Erdemli, Haisong Ju, Sarita Pereira; title: The Mechanistic Basis of hERG Blockade and the Proarrhythmic Effects Thereof / Robert A Pearlstein, K Andrew MacCannell, Qi-Ying Hu, Ramy Farid, José S Duca; title: Kinase Antitargets.; title: Introduction to Kinase Antitargets / Mark C Munson; title: Clinical and Nonclinical Adverse Effects of Kinase Inhibitors / Douglas A Keller, Richard J Brennan, Karen L Leach; title: Cardiac Side Effects Associated with Kinase Proteins and Their Signaling Pathways / Roy J Vaz, Vinod F Patel; title: Case Studies: Selective Inhibitors of Protein Kinases : Exploiting Demure Features / Ellen R Laird; title: Examples of Clinical Translation.; title: Torcetrapib and Dalcetrapib Safety: Relevance of Preclinical and Models / Eric J Niesor, Andrea Greiter-Wilke, Lutz Müller; title: Targets Associated with Drug-Related Suicidal Ideation and Behavior / Andreas Hartmann, Steven Whitebread, Jacques Hamon, Alexander Fekete, Christian Trendelenburg, Patrick Y Müller, László Urbán