BACE
Subtitle: lead target for orchestrated therapy of Alzheimer's disease
By: [edited by] Varghese John.
Contributors: John, Varghese, 1958-
Publisher: John Wiley & Sons
Published: 2010
Place of publication: Hoboken, N.J
Language: eng
ISBN-13: 9780470293423
Subjects: Alzheimer's disease -- Chemotherapy; Aspartic proteinases -- Inhibitors -- Therapeutic use; Amyloid beta-protein precursor; Alzheimer Disease -- drug therapy; Amyloid Precursor Protein Secretases -- pharmacology; Amyloid Precursor Protein Secretases -- therapeutic use
Notes: Includes bibliographical references and index.
Table of contents: title: BACE : APP processing, and signal transduction in Alzheimer's disease (AD) / Dale E. Bredesen and Edward H. Koo; title: Identification of BACE as an AD target / Robert L. Heinrikson and Sukanto Sinha; title: BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski; title: Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott; title: Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig; title: Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veer Shanmugasundaram, and Alfredo G. Tomasselli; title: Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head; title: Adsorption, distribution, metabolism, excretion (ADME), efficacy & toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont; title: Clinical trials for disease modifying drugs such as BACE inhibitors / Henry Hsu; title: Future strategies for development of novel BACE inhibitors : anti-APP e-site antibody & APP binding small molecule approaches for Alzheimer's disease / Beka Solomon ... [et al.].