Modern Nucleophilic Aromatic Substitution
Publisher: Wiley-VCH Verlag GmbH
Published: 2013
Language: eng
Number of pages: 472
ISBN-13: 9783527318612
Description: This book provides a comprehensive overview of nucleophilic aromatic substitutions, focusing on the mechanistic and synthetic features that govern these reactions. The first chapter presents a detailed mechanistic analysis of the factors determining the feasibility of SNAr substitutions, providing decisive information to predict regioselectivity of many reactions and to define the conditions for concerted SNAr processes. Reflecting the key role played by these species as intermediates in most SNAr reactions, chapter 2 then discusses the chemistry of anionic sigma-complexes.