Enhancing Statistician Power
Subtitle: Flexible Covariate-adjusted Semiparametric Inference for Randomized Studies with Multivariate Outcomes
Contributors: De Gruttola, Victor; Tchetgen Tchetgen, Eric J.; Lin, Xihong
Published: 2012
Language: eng
Description: It is well known that incorporating auxiliary covariates in the analysis of randomized clinical trials (RCTs) can increase efficiency. Questions still remain regarding how to flexibly incorporate baseline covariates while maintaining valid inference. Recent methodological advances that use semiparametric theory to develop covariate-adjusted inference for RCTs have focused on independent outcomes. In biomedical research, however, cluster randomized trials and longitudinal studies, characterized by correlated responses, are commonly used. We develop methods that flexibly incorporate baseline covariates for efficiency improvement in randomized studies with correlated outcomes.
Notes: Keywords: Clinical Trials, Cluster randomized trials, Covariate adjustment, Longitudinal, Semiparametric Efficiency.

Thesis Ph.D. Harvard University 2012