Adaptive design methods in clinical trials
By: authors, Shein-Chung Chow, Mark Chang
Contributors: Chang, Mark
Edition: 2nd ed.
Series: Chapman & Hall/CRC biostatistics series; Chapman & Hall/CRC biostatistics series (Unnumbered)
Publisher: Taylor & Francis
Published: 2012
Place of publication: Boca Raton
Language: eng
Number of pages: 358
ISBN-13: 9781439839874
Subjects: Research Design; Statistical Models; Methods; Clinical Trials as Topic; Biometry
Notes: Includes bibliographical references and index.
Table of contents: title: Protocol amendment; title: Adaptive randomization; title: Adaptive hypotheses; title: Adaptive dose-escalation trials; title: Adaptive group sequential design; title: Statistical tests for adaptive seamless designs; title: Adaptive sample size adjustment; title: Two-stage adaptive design; title: Adaptive treatment switching; title: Bayesian approach; title: Biomarker adaptive trials; title: Target clinical trials; title: Sample size and power estimation; title: Clinical trial simulation; title: Regulatory perspectives : a review of FDA draft guidance.