Do depressive symptoms affect adherence to study medication by postmenopausal women in an osteoporosis prevention trial?
Published: 2006
Language: eng
Number of pages: 112
ISBN-13: 9780494214497
Description: Objective. To determine if depressive symptoms were associated with nonadherence to study drug and to construct a prediction model in an osteoporosis preventive trial (ECKO).Method. We used data collected from 301 of 441 participants in the ECKO trial. Adherence was measured by pill counts. The Mental Health Inventory (MHI) score (Increasing scores indicated poorer mental health) measured depressive symptoms.Conclusion. Increasing depressive symptoms were associated with nonadherence.Results. At one year 25.8% were nonadherent. While controlling for 9 covariates, the odds of nonadherence increased by 1.111 for every one-point increase in the MHI score (p = 0.0 100). In the prediction model, MHI score (OR = 1.105; p = 0.0121), being married (OR = 0.523; p = 0.0241), use of over the counter medications (OR = 0.352; p = 0.0064), and the late return of study bottles (OR = 2.206; p = 0.0485) were significantly associated with nonadherence.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1476.

Thesis (M.Sc.)--University of Toronto, 2006.

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