The effects of insulin-like growth factor binding protein-1 on pre- and postnatal cardiac morphology and function.
Published: 2007
Language: eng
Number of pages: 153
ISBN-13: 9780494273951
Description: Insulin-like growth factors (IGFs) are essential regulators of fetal growth. Their effects are modulated by the IGF binding proteins (IGFBPs). Circulating IGFBP-1 levels are elevated in growth-restricted human fetuses, and fetal growth restriction increases the risk of cardiovascular diseases in adulthood. Transgenic mice with elevated levels of circulating IGFBP-1 in late gestation were shown to be growth restricted, and have improved overall left and right ventricular function, eccentric left ventricular hypertrophy, cardiomyocyte hypertrophy, and decreased cardiomyocyte proliferation at E17.5. Postnatally, transgenic mice did not exhibit catch-up growth and showed left ventricular overall, diastolic, and systolic functional impairments, and wall thinning in adulthood (&ge;8 week). We conclude that growth restriction caused by elevated IGFBP-1 alters pre- and postnatal cardiac structure and function and this may increase the risk of cardiovascular disease in adulthood.
Notes: Source: Masters Abstracts International, Volume: 45-06, page: 3029.

Thesis (M.Sc.)--University of Toronto, 2007.

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