Cancer genome and tumor microenvironment
By: Andrei Thomas-Tikhonenko, editor
Publisher: Springer
Published: 2010
Place of publication: New York
Language: eng
Number of pages: 497
ISBN-13: 9781441907103; 9781441907110
Subjects: Genomics; Immunology; Cancer; Tumors; Neoplasms; Etiology; Genetic aspects; Genetics
Description: Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late .80s-early .90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are "soft-wired", i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.
Notes: Includes bibliographical references and index.