Handbook of anxiety and fear
By: edited by Robert J. Blanchard ... [et al.].
Contributors: ScienceDirect (Online service)
Series: Handbook of behavioral neuroscience -- v. 17
Publisher: Academic Press
Published: 2008
Place of publication: Amsterdam; Oxford
Language: eng
Format: [electronic resource] /
ISBN-13: 9780444530653
Subjects: Anxiety disorders; Anxiety; Animal models in research; Chemotherapy; Fear; Physiological aspects; Research
Description: This Handbook brings together and integrates comprehensively the core approaches to fear and anxiety. Its four sections: Animal models; neural systems; pharmacology; and clinical approaches, provide a range of perspectives that interact to produce new light on these important and sometimes dysfunctional emotions. Fear and anxiety are analyzed as patterns that have evolved on the basis of their adaptive functioning in response to threat. These patterns are stringently selected, providing a close fit with environmental situations and events; they are highly conservative across mammalian species, producing important similarities, along with some systematic differences, in their human expression in comparison to that of nonhuman mammals. These patterns are described, with attention to both adaptive and maladaptive components, and related to new understanding of neuroanatomic, neurotransmitter, and genetic mechanisms.^

Although chapters in the volume acknowledge important differences in views of fear and anxiety stemming from animal vs. human research, the emphasis of the volume is on a search for an integrated view that will facilitate the use of animal models of anxiety to predict drug response in people; on new technologies that will enable direct evaluation of biological mechanisms in anxiety disorders; and on strengthening the analysis of anxiety disorders as biological phenomena.^

Integrates animal and human research on fear and anxiety Presents emerging and developing fields of human anxiety research including imaging of anxiety disorders, the genetics of anxiety, the pharmacology of anxiolysis, recent developments in classification of anxiety disorders, linking these to animal work Covers basic research on innate and conditioned responses to threat Presents work from the major laboratories, on fear learning and extinction Reviews research on an array of neurotransmitter and neuromodulator systems related to fear and anxiety Compares models, and neural systems for learned versus unlearned responses to threat Relates the findings to the study, diagnostics, and treatment of anxiety disorders, the major source of mental illness in modern society (26 % of Americans are affected by anxiety disorders!).
Notes: Includes bibliographical references and index.

Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2008. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on May 14, 2008). Access may be restricted to users at subscribing institutions.
Table of contents: title: Section 1. Introduction; title: Introduction to the Handbook on Fear and Anxiety; title: Robert Blanchard, D. Caroline Blanchard, Guy Griebel and David Nutt; title: Section 2. Animal models of Anxiety, Fear and Defense; title: Theoretical approaches to the modeling of anxiety in animals; title: Neil McNaughton and Ȟlio Zangrossi Jr.,; title: The use of conditioning tasks to model fear and anxiety; title: Michael S. Fanselow and Ravikumar Ponnusamy; title: Extinction of fear: from animal studies to clinical interventions; title: Karyn M. Myers and Michael Davis; title: Defensive behaviors, fear and anxiety; title: D. Caroline Blanchard and Robert Blanchard; title: Unconditioned models of fear and anxiety; title: Yoav Litvin, Nathan S. Pentkowski, Roger L. Pobbe, D. Caroline Blanchard and Robert J. Blanchard; title: Section 3. Neural Systems for Anxiety, Fear, and Defense; title: Brain mechanisms of Pavlovian and instrumental aversive conditioning; title: Christopher K. Cain and Joseph E. LeDoux; title: ^; title: Neural systems activated in response to predators and partial predator stimuli; title: Newton Sabino Canteras; title: A behavioral and neural systems comparison of unconditioned and conditioned defensive behavior; title: Newton S. Canteras and D. Caroline Blanchard; title: Section 4. The Pharmacology of Anxiety, Fear, and Defense; title: Peptide receptor ligands to treat anxiety disorders; title: Thomas Steckler; title: Subtype-selective GABAA/benzodiazepine receptor ligands for the treatment of anxiety disorders; title: James K. Rowlett; title: Modulation of anxiety behaviors by 5-HT-interacting drugs; title: Francisco Silveira Guimar̂es, Antonio P̀dua Carobrez and Frederico Guilherme Graeff; title: The glutamatergic system as a potential therapeutic target for the treatment of anxiety disorders; title: John F. Cryan and Kumlesh K. Dev; title: The endocannabinoid system and anxiety responses; title: Marco Bortolato and Daniele Piomelli; title: ^; title: ^^; title: Genetic factors underlying anxiety-behaviour: a meta-analysis of rodent studies involving targeted mutations of neurotransmission genes; title: Catherine Belzung, Samuel Leman and Guy Griebel; title: The pharmacology of anxiolysis; title: Andrew Holmes; title: Section 5. Handbook of Fear and Anxiety:; title: Clinical and Experimental Considerations; title: Phenomenology of anxiety disorders; title: David J. Nutt, Berta Garcia de Miguel and Simon J.C. Davies; title: How effective are current drug treatments for anxiety disorders, and how could they be improved?; title: David S. Baldwin and Matthew J. Garner; title: Experimental models: panic and fear; title: Gabriel Esquivel, Koen Schruers and Eric Griez; title: Principles and findings from human imaging of anxiety disorders; title: Andrea L. Malizia and David Nutt; title: Stress hormones and anxiety disorders; title: Elizabeth A. Young, James L. Abelson and Israel Liberzon; title: The genetics of human anxiety disorders; title: Eduard Maron, John M. Hettema and Jakov Shlik.; title: ^^