RNA interference
Subtitle: challenges and therapeutic opportunities
By: edited by Mouldy Sioud
Series: Methods in Molecular Biology -- 1218; Springer protocols; Methods in molecular biology (Clifton, N.J.) -- v. 1218.; Springer protocols (Series)
Publisher: Humana Press
Published: 2015
Place of publication: New York
Language: eng
Number of pages: 495
ISBN-13: 9781493915378; 9781493915385
Subjects: Interférence par ARN; Thérapie; Tumeurs; Small Interfering RNA; Petit ARN d'interférence; Mécanismes génétiques; Therapeutic use; Physiologie; RNA Interference; Thérapie génétique; Usage thérapeutique; RNA editing; Extinction de l'expression des gènes; Small interfering RNA; Laboratory manuals; Gene silencing
Notes: Includes bibliographical references and index.
Table of contents: title: RNA interference : mechanisms, technical challenges, and therapeutic opportunities  -- Mouldy Sioud; title: Nanostructured RNAs for RNA interference  -- Yuko Nakashima [and others]; title: One long oligonucleotide or two short oligonucleotides based shRNA construction and expression  -- Xue-jun Wang and Sheng-qi Wang; title: PLGA microspheres encapsulating siRNA  -- Giuseppe De Rosa and Giuseppina Salzano; title: Magnetic nanoparticle and magnetic field assisted siRNA delivery in vitro  -- Olga Mykhaylyk [and others]; title: Cytoplasmic delivery of siRNAs to monocytes and dendritic cells via electroporation  -- Mouldy Sioud; title: Delivery of siRNAs to cancer cells via bacteria  -- Omar Ahmed, Andrea Krühn, and Hermann Lage; title: Microwell array-mediated delivery of lipoplexes containing nucleic acids for enhanced therapeutic efficacy  -- Yun Wu, Daniel Gallego-Perez, and L. James Lee; title: Modulating the tumor microenvironment with RNA interference as a cancer treatment strategy  -- Karin Zins [and others]; title: Targeted in vivo delivery of siRNA and an endosome- releasing agent to hepatocytes  -- Magdolna G. Sebestyén [and others]; title: Cell-internalization SELEX : method for identifying cell- internalizing RNA aptamers for delivering siRNAs to target cells  -- William H. Thiel [and others]; title: Strategies for siRNA navigation to desired cells  -- Mouldy Sioud; title: Use of guanidinopropyl-modified siRNAs to silence gene expression  -- Maximilian C.R. Buff [and others]; title: Therapy of respiratory viral infections with intranasal siRNAs  -- Sailen Barik and Patrick Lu; title: Engineering therapeutic cancer vaccines that activate antitumor immunity  -- Per Ole Iversen and Mouldy Sioud; title: Immunosuppressive factor blockade in dendritic cells via siRNAs results in objective clinical responses  -- Mouldy Sioud, Anne Mobergslien, and Stein Sæbøe-Larssen; title: Targeting bcr-abl transcripts with siRNAs in an imatinib- resistant chronic myeloid leukemia patient : challenges and future directions  -- Michael Koldehoff; title: Facile method for interfering with off-target silencing mediated by the sense strand  -- Anne Mobergslien and Mouldy Sioud; title: Overcoming the challenges of siRNA activation of innate immunity : design better therapeutic siRNAs  -- Mouldy Sioud; title: Gene silencing in vitro and in vivo using intronic microRNAs  -- Jia Han Deng [and others]; title: In silico identification of novel endo-siRNAs  -- Andrew Schuster [and others]; title: Computer-assisted annotation of small RNA transcriptomes  -- Nicole Ortogero [and others]; title: miR-CATCH : microRNA capture affinity technology  -- Sebastian Vencken [and others]; title: Roles of MicroRNAs in cancers and development  -- Shigeru Takasaki; title: Targeting microRNAs to withstand cancer metastasis  -- Valentina Profumo [and others]; title: Urinary microRNAs as a new class of noninvasive biomarkers in oncology, nephrology, and cardiology  -- Hana Mlcochova [and others]; title: Magnetic bead-based isolation of exosomes  -- Morten P. Oksvold, Axl Neurauter, and Ketil W. Pedersen; title: Modified 2'-ribose small RNAs function as toll-like receptor-7/8 antagonists -- Mouldy Sioud.