Differential effect of macronutrient ingestion on cognitive performance in individuals with type 2 diabetes mellitus.
Published: 2007
Language: eng
Number of pages: 112
ISBN-13: 9780494273784
Description: Ingestion of high glycemic-index carbohydrate foods results in cognitive deficits in individuals with type 2 diabetes mellitus (T2DM), yet the mechanisms remain unclear. This thesis distinguished between nutrient-induced increases in glucose, insulin, or cortisol as potential mediators of cognitive dysfunction using pure nutrient drinks differing in their impact on these parameters. On paragraph recall, mediated by the hippocampus, both glucose and protein ingestion resulted in poorer performance 20 to 100 minutes post ingestion in 30 adults with T2DM and these decrements associated with nutrient-induced increases in salivary cortisol. In contrast, protein ingestion enhanced performance on the executive components of Stroop and Trails, which associated with higher post-prandial insulin area under the curve. These results suggest that cognitive performance is not affected equally by nutrient-induced endocrine responses in adults with T2DM. Thus, acute hypercortisolemia may be detrimental to hippocampul-mediated tasks and executive function may be enhanced during periods of acute hyperinsulinemia.
Notes: Source: Masters Abstracts International, Volume: 45-06, page: 3136.

Thesis (M.Sc.)--University of Toronto, 2007.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.