An economic model of amniocentesis choice
By: Eduardo Fajnzylber, V. Joseph Hotz, Seth G. Sanders
Contributors: Hotz, V. Joseph; Sanders, Seth, 1962-; National Bureau of Economic Research
Series: NBER working paper series -- working paper 16306; Working paper series (National Bureau of Economic Research : Online) -- working paper no. 16306.
Publisher: National Bureau of Economic Research
Published: 2010
Place of publication: Cambridge, MA
Language: eng
Format: Electronic resource
Description: "Medical practitioners typically utilize the following protocol when advising pregnant women about testing for the possibility of genetic disorders: Pregnant women over the age of 35 should be tested for Down syndrome and other genetic disorders; for younger women, such tests are discouraged since they can cause a miscarriage.  The logic appears compelling.  The rate at which amniocentesis causes a miscarriage is constant while genetic disorders rise over a woman's reproductive years.  Hence the potential benefit from testing - being able to terminate a fetus with a genetic disorder - rises with maternal age.  We argue that this logic is incomplete.  While the benefits to testing rise with age, so do the costs.  While undergoing an amniocentesis always entails the risk of miscarriage of a healthy fetus, these costs are lower at early ages, because there is a higher probability of being able to replace a miscarried fetus with a healthy birth at a later age.  We develop and calibrate a dynamic model of amniocentesis choice to explore this tradeoff.  For parameters that characterize realistic age patterns of chromosomal abnormalities, fertility rates and miscarriages following amniocentesis, our model implies a falling, rather than rising, rate of amniocentesis as women approach menopause"--National Bureau of Economic Research web site.
Notes: Title from PDF file as viewed on 9/28/2010.

Includes bibliographical references.

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