Epigenetics
Subtitle: mechanisms, functions and human effects
By: Balázs Pintér and Zsolt Mészáros, editors
Series: Genetics--research and issues series
Publisher: Nova Science Publishers
Published: 2010
Place of publication: New York
Language: eng
Number of pages: 303
ISBN-13: 9781607414544
Description: "Epigenetics refers to DNA and chromatin modifications that persist from one cell division to the next despite a lack of change in the underlying DNA sequence. It is an emergent field since its implication in physiological and disease processes is now widely accepted. The effects of epigenetics play an important role in development but can also arise stochastically with aging. Since their discovery in 1983, cancer-associated epigenetic changes have become accepted as playing a pivotal role in carcinogenesis, in conjunction with classical genomic mutations. Thus it is now well established that an epigenetic mechanism underlies the pathogenesis of cancer and there is evidence implicating epigenetic factors in the pathogenesis of idiopathic mental disorders such as schizophrenia, bipolar disorder and even autism. This new book gathers the latest research from around the globe in this field of study and related topics."--Publisher's description.
Notes: Includes bibliographical references and index.
Table of contents: title: Techniques in cancer epigenetics / Michele Cummings and Laura Smith; title: Melatonin : epigenetic mechanisms in cancer inhibition / Ahmet Korkmaz and Russel J. Reiter; title: The epigenetic (re)programming of phenotypic differences in behavior / Patrick O. McGowan, Michael J. Meaney and Moshe Szyf; title: Role of H3 phosphorylation in different biological processes in normal and disease states / Geneviève P. Delcuve, Paula S. Espino and James R. Davie; title: The role of DNA methylation in colorectal cancer / Ivana Fridrichova; title: Epigenetic clues to arthritic diseases / Helmtrud I. Roach and Emma L. Williams; title: Evolution of the Fpg/Nei family of DNA glycosylases / Dorothy E. Pumo ... [et al.]; title: The clinical and etiological relevance of MLH1 promoter hypermethylation in ovarian tumors / Tuya Pal and O. Thomas Mueller; title: Epigenetic role in longevity echoes conserved stress survival strategies / Joan Smith Sonneborn; title: Epigenetics and neurodegeneration : a connection overlooked / Sueli C.F. Marques, Clâaudia M.F. Pereira and Tiago F. Outeiro; title: DNA methylation changed by 5-azacytidine can affect normal fetal and placental development / Ljiljana Serman ... [et al.]; title: Epigenetic analysis in breast cancer progression / Frank A. Orlando, Lisa M. Dyer and Kevin D. Brown; title: Cancer epigenetics / Frank A. Orlando, Berna Demircan and Kevin D. Brown.