A role for the nuclear receptor PPARγ in cancer
By: a thesis presented by Pasha Sarraf
Published: 2000
Language: eng
Subjects: Metabolism; Regulations; Nuclear receptors (Biochemistry); Receptor-ligand complexes; Breast; Cancer; Colon (Anatomy)
Notes: Thesis (Ph. D., Division of Medical Sciences (Cell and Developmental Biology))--Harvard University, 2002.

Includes bibliographical references.

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Table of contents: title: Includes eight offprints (1-4):; title: Terminal differentiation of human breast cancer through PPARγ -- (Molecular cell, v.1, February 1998, pp. 465-470); title: Differentiation and reversal of malignant changes in colon cancer through PPARγ -- (Nature medicine, v.4:9, September 1998, pp. 1046-1052); title: Loss-of-function mutations in PPARγ associated with human colon cancer -- (Molecular cell, v.3, June 1999, pp. 799-804); title: Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated γ and the retinoid X receptor-- (Proceedings of the National Academy of Sciences, v.94, January 1997, pp. 237-241); title: Includes eight offprints (5-8):; title: Inhibition of apidogenesis through MAP kinase-mediated phosphorylation of PPARγ -- (Science, v.274, December 20, 1996, pp. 2100-2103); title: Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 -- (Journal of clinical investigation, v.101:1, January 1998, pp. 1-9); title: Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma -- (Proceedings of the National Academy of Sciences, v.96, March 1999, pp. 3951-3956); title: PPARγ is required for the differentiation of adipose tissue in vivo and in vitro-- (Molecular Cell, v.4, October 1999, pp. 611-617)