Investigation of the molecular alterations in synchronous breast cancer using array and chromosomal comparative genomic hybridization.
Published: 2005
Language: eng
Number of pages: 131
Description: Studying multiple tumors in the same patient provides a valuable opportunity to identify genetic markers specific to the tumors while controlling for patient specific genetic background changes. Using chromosomal and array comparative genomic hybridization, the genetic alterations of 23 synchronous breast cancers from 10 patients at both the gene and chromosomal level were examined. JAK1 was found to be amplified in 100% of our cases. MYC, MAP3K12, TIMP2 and TIMP3 were amplified respectively in 78%, 69.6%, 48% and 48% whereas ATM was deleted in 74% of the cases. The prominent chromosomal alterations were gain of 1q, 3p, 4q, 8q and loss of 11q, 12q, 16q and 17p. Our CGH data revealed that synchronous tumours in a given patient, despite their similar genomic alterations, had unique genomic profiles. This bears potential therapeutic implications in designing clinical treatment for patients with synchronous breast cancer.
Notes: Source: Masters Abstracts International, Volume: 44-01, page: 0323.

Thesis (M.Sc.)--University of Toronto, 2005.

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