Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors
Subtitle: Her3 and KRas
Contributors: Gray, Nathanael S.; Janne, Pasi A.; Saghatelian, Alan
Published: 2014
Language: eng
Description: With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted with small molecule inhibitors. During the past five years, I have been working on figuring out the path to inhibit two elusive cancer targets: Her3 and KRas.
Notes: Keywords: Her3, KRas.

Thesis Ph.D. Harvard University 2014