Oral drug absorption
Subtitle: prediction and assessment
By: edited by Jennifer B. Dressman, Hans Lennernäs.
Contributors: Dressman, J. B.; Lennernäs, Hans.
Series: Drugs and the pharmaceutical sciences -- 106.
Publisher: Marcel Dekker
Published: 2000
Place of publication: New York
Language: eng
Number of pages: 330
Subjects: Bioavailability.; Drugs -- Administration.; Drug metabolism.; Pharmacology.; Pharmaceutical Preparations -- metabolism.; Administration, Oral.; Biological Availability.; Solubility.
Notes: Includes bibliographical references and index.
Table of contents: title: I. Gastrointestinal variables; title: Gastrointestinal transit and drug absorption; title: Permeability in the gastrointestinal tract; title: Gastrointestinal disease and dosage form performance; title: II. Membrane permeability; title: Intestinal permeability: prediction from theory; title: In vitro methods for the assessment of permeability; title: Animal perfusion studies; title: Human perfusion studies; title: The role of permeability studies in preclinical evaluation; title: III. Solubility and drug dissolution; title: Solubility as a limiting factor to drug absorption; title: Dissolution testing of immediate-release products; title: Dissolution testing in the development or oral drug products; title: Analysis of drug dissolution data; title: IV. In vivo-in vitro correlations; title: Convolution and deconvolution methods; title: The correlation of in vitro and in vivo drug dissolution; title: IVIVC: a perspective from the workbench.