Therapeutic targets of the TNF superfamily
By: edited by Iqbal S. Grewal.
Contributors: Grewal, Iqbal S.
Series: Advances in experimental medicine and biology -- v. 647
Publisher: Springer Science+Business Media; Landes Bioscience
Published: 2009
Place of publication: New York; Austin, Tex
Language: eng
ISBN-13: 9780387895192
Subjects: Tumor necrosis factor; Tumor necrosis factor -- Agonists -- Therapeutic use; Tumor Necrosis Factors -- therapeutic use; Autoimmune Diseases -- drug therapy; Inflammation -- drug therapy; Neoplasms -- drug therapy; Receptors, Tumor Necrosis Factor -- therapeutic use
Description: This volume presents the state-of-the art account on the role of TNF superfamily members in the pathogenesis and their use in current intervention of cancers and autoimmune disease. This text will be highly valuable for investigators to understand the disease processes regulated by TNF superfamily members and to develop effective therapeutics. A view into the future, inspired by the comprehensive work presented in this volume, predicts that researchers studying TNF superfamily members will continue to make rapid progress in identifying relevant components to the disease process and new therapeutic strategies to target many human diseases including cancers, autoimmune disease and others.
Notes: Includes bibliographical references and index.
Table of contents: title: Overview of TNF superfamily : a chest full of potential therapeutic targets / Iqbal S. Grewal; title: Therapeutic interventions targeting CD40l (CD154) and CD40 : the opportunities and challenges / Che-Leung Law and Iqbal S. Grewal; title: Targeting TNF for treatment of cancer and autoimmunity / Gautam Sethi ... [et al.]; title: Targeting of BAFF and APRIL for autoimmunity and oncology / Maureen C. Ryan and Iqbal S. Grewal; title: The role of FASL and FAS in health and disease / Martin Ehrenschwender and Harald Wajant; title: OX40 (CD134) and OX401 / Michael J. Gough and Andrew D. Weinberg; title: Targeting CD70 for human therapeutic use / Tamar Boursalian ... [et al.]; title: 4-1BB as a therapeutic target for human disease / Seung-Woo Lee and Michael Croft; title: Rank(l) as a key target for controlling bone loss / Andreas Leibbrandt and Josef M. Penninger; title: Targeting the light-HVEM pathway / Carl F. Ware; title: GITR : a modulator of immune response and inflammation / Giuseppe Nocentini and Carlo Riccardi; title: Targeting CD30/CD30l in oncology and autoimmune and inflammatory diseases / Ezogelin Oflazoglu, Iqbal S. Grewal, and Hans Peter Gerber; title: Tumor necrosis factor receptor superfamily member 21 : TNFR-related death receptor-6, DR6 / Robert Benschop, Tao Wei, and Songqing Na; title: TRAIL and other TRAIL receptor agonists as novel cancer therapeutics / Christina Falschlehner ... [et al.]; title: Therapeutic potential of VEGI/TL1A; title: In autoimmunity and cancer / Gautam Sethi, Bokyung Sung, and Bharat B. Aggarwal.