Approaches to the conformational analysis of biopharmaceuticals
By: Roger L. Lundblad.
Series: Protein science; Protein science series
Publisher: CRC Press/Taylor & Francis
Published: 2010
Place of publication: Boca Raton
Language: eng
ISBN-13: 9781439807804
Subjects: Protein drugs -- Conformation; Pharmaceutical biotechnology; Biopharmaceutics -- methods; Protein Conformation; Proteins -- analysis
Notes: Includes bibliographical references and index.
Table of contents: title: Introduction to biopharmaceutical conformational analysis : issues and methods; title: Comparability of biotechnological/biologic products and biological generics; title: Application of native electrophoresis for the study of protein conformation; title: Affinity chromatography including hydrophobic interaction chromatography in the study of biopolymer conformation; title: Size-exclusion chromatography and bimolecular conformation; title: The use of analytical ultracentrifugation to study biomolecular conformation; title: Use of differential scanning calorimetry to measure conformational change in proteins and other biomacromolecules; title: Light scattering and biomacromolecular conformation; title: Use of luminescence to measure conformational change in biopharmaceuticals with emphasis on protein and protein drug products; title: Near-infrared (NIR) spectroscopy and macromolecular conformation; title: The use of mid-infrared and Fourier transform infrared (FTIR) spectroscopy to study biomacromolecule conformation; title: The use of Raman spectroscopy to evaluate biopharmaceutical conformation; title: The use of UV-VIS spectrophotometry for the characterization of biopharmaceutical products; title: The use of optical rotatory dispersion and circular dichroism to study therapeutic biomacromolecule conformation; title: The use of nuclear magnetic resonance for the characterization of biotherapeutic products; title: Use of chemical probes for the study of protein conformation; title: The use of hydrogen exchange in the study of biopharmaceutical conformation; title: Use of chemical modification for the conformational analysis of biopharmaceuticals; title: The use of immunology to characterize biopharmaceutical conformation; title: The use of limited proteolysis to study the conformation of proteins of biotechnology interest; title: Other technologies for the characterization of conformational change in biopharmaceuticals; title: Development of an experimental approach for the study of the conformation of a biological therapeutic product.