Multiple Myeloma (State of the Art)
Contributors: Paul Richardson (Editor); Ken Anderson (Editor)
Publisher: Remedica Publishing
Published: August 30, 2004
Language: eng
Format: Paperback
Number of pages: 198
ISBN-13: 9781901346480
Subjects: Haematology; Medical / Nursing; Medical; Hematology; Oncology
First sentence: Multiple myeloma (MM) is a malignant plasma cell tumor that is distributed at multiple sites within the bone marrow (BM) compartment.
Description: Multiple myeloma is the second most common hematologic malignancy, affecting 15,000 patients per year in the United States. Despite the advent of high-dose chemotherapy with stem cell transplantation, multiple myeloma remains incurable, with approximately 12,000 deaths per annum recorded in the US from the disease. Over the last 10 years, there has been a dramatic increase in our understanding of the biology of multiple myeloma, which has provided insights into mechanisms of cytotoxic resistance, both as inherent characteristics of the myeloma cell and the protective interaction between the tumor and its bone marrow microenvironment. Moreover, advances in our understanding of multiple myeloma pathogenesis have helped further define the intricacies of this complex disease. This book provides a concise overview of the state-of-the-art in multiple myeloma and should be of primary interest to clinicians as well as scientists and related caregivers alike in this rapidly changing f.