Data management of protein interaction networks
By: Mario Cannataro, Pietro Hiram Guzzi
Contributors: Guzzi, Pietro Hiram, 1980-
Series: Wiley series in bioinformatics -- 17
Publisher: Wiley
Published: 2012
Place of publication: Hoboken, NY
Language: eng
ISBN-13: 9780470770405
Subjects: Protein-protein interaction; Information resources; Information resources management; COMPUTERS / Computer Engineering
Description: "Current PPI databases do not offer sophisticated querying interfaces and especially do not integrate existing information about proteins. Current algorithms for PIN analysis use only topological information, while emerging approaches attempt to exploit the biological knowledge related to proteins and kinds of interaction, e.g. protein function, localization, structure, described in Gene Ontology or PDB.  The book discusses technologies, standards and databases for, respectively, generating, representing and storing PPI data. It also describes main algorithms and tools for the analysis, comparison and knowledge extraction from PINs. Moreover, some case studies and applications of PINs are also discussed"--