The Molecular Basis of Skeletogenesis
Series: Novartis Foundation Symposium 232; Novartis Foundation Symposium 232
Publisher: John Wiley & Sons
Published: 2001
Place of publication: Chichester
Language: eng
Format: [electronic resource]
Number of pages: 305
ISBN-13: 9780470853757
Description: This book brings together a cross-fertilization of ideas between human molecular genetics, developmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis. This broad perspective is essential in order to understand the aetiology of genetic diseases affecting skeletal development at all levels from genotype to phenotype, i.e. from mutation to syndrome.
Notes: Description based on print version record.
Table of contents: title: THE MOLECULAR BASIS OF SKELETOGENESIS Contents Introduction Genetic control of skeletal development Early steps in limb patterning and chondrogenesis General discussion I.; title: Developmental mechanisms of vertebrate limb evolution Regulation of chondrocyte growth and differentiation by fibroblast growth factor receptor 3.; title: Defects of human skeletogenesis; title: models and mechanisms.; title: Genetic control of the cell proliferation-differentiation balance in the developing skull vault: roles of fibroblast growth factor receptor signalling pathways.; title: Craniosynostosis and related limb anomalies The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plate Cartilage matrix resorption in skeletogenesis.