Methods in psychobiology
Subtitle: Advanced laboratory techniques in neuropsychology and neurobiology
By: edited by R.D. Myers
Publisher: Academic Press
Published: 1977
Place of publication: London; New York
Language: eng
Number of pages: 339
ISBN-13: 9781483266978; 9780124610033
Subjects: Psychobiology; Technique; Neurophysiology; Psychophysiology; SOCIAL SCIENCE; Anthropology; Physical
Other titles: Advanced laboratory techniques in neuropsychology and neurobiology
Description: Methods in Psychobiology, Volume 3, Advanced Laboratory Techniques in Neuropsychology and Neurobiology is devoted in large measure to specialized techniques that are widely used in the fields of psychobiology and neurobiology. The experimental methods described form a companion to those presented in Volumes 1 and 2. Many of the procedures presented hinge directly on a mastery of the more rudimentary techniques dealt with in the earlier volumes. The emphasis in the content of this book is on one facet of neurobiology, the mammalian central nervous system. The central or peripheral processes tha.
Notes: Includes bibliographical references and indexes.
Table of contents: title: Front Cover; Methods in Psychobiology: Advanced Laboratory Techniques in Neuropsychology and Neurobiology; Copyright Page; Table of Contents; List of Contributors; Preface; Chapter 1. Anatomical Analysis of Neuronal Connectivity; I. INTRODUCTION; II. ANATOMICAL METHODS; REFERENCES; Chapter 2. Chemical Lesioning: Catecholamine Pathways; I. PERIPHERAL ADMINISTRATION OF 6-HYDROXYDOPAMINE; II. CENTRAL ADMINISTRATION OF 6-HYDROXYDOPAMINE; III. PREFERENTIAL REDUCTION OF BRAIN NOREPINEPHRINE; IV. PREFERENTIAL DESTRUCTION OF DOPAMINE PATHWAYS; V. ANIMAL CARE AFTER 6-HYDROXYDOPAMINE ADMINISTRATION.; title: VI. EVIDENCE FOR SPECIFICITY OF 6-HYDROXYDOPAMINEVll. EVIDENCE FOR ACTIVATION OF COMPENSATORY MECHANISMS FOLLOWING 6-HYDROXYDOPAMINE TREATMENTS; VIII. USE OF 6-HYDROXYDOPAMINE IN NEUROBIOLOGY AND NEUROPHARMACOLOGY; ACKNOWLEDGMENTS; REFERENCES; Chapter 3. Chemical Lesioning of Indoleamine Pathways; I. INTRODUCTION; II. HISTORICAL REVIEW; III. GENERAL COMMENTS ON THE DRUGS AND THEIR ADMINISTRATION; IV. EFFECTS OF INTRAVENTRICULAR ADMINISTRATION OF 5, 6; title: OR 5,7-DIHYDROXYTRYPTA MINE ON CNS MONOAMINE CONTENT IN THE ADULT RAT.; title: V. effects of intracisternal administration of 5, 6; title: or 5, 7; title: dht on cns monoamine contentin the adult ratvi. effects of intraventricular administration of 5, 6; title: or 5, 7; title: dht or 6-ohda on monoamine biosynthetic enzymes; vii. effects of intraventricular or intracisternal 5,6-or 5,7-dht on brain and spinal cord 5-hydroxyindoleacetic acid; viii. effects of intraventricular injections of 5,6-or 5,7-dht on the morphology of central monoamine neurons; ix. effects of intracerebral injections of 5,6-and 5,7-dht in the adult rat.; title: X. affinity to monoaminergic uptake sites as a determinant of selectivity of action of neurotoxic tryptaminesxi. uptake impairment as a determinant of the neurotoxic potency of tryptamine analogs; xii. reduction of [3h]amine uptake as a measure of terminal degeneration; xiii. distribution of [14c]5,6-dht in brain after intraventricular injection; xiv . effects of drugs on the toxic actions of 5,6-or 5,7-dht in the adult rat; xv. intracisternal, intraventricular, or peripheral administration of 5,6- or 5,7-dht in the developing rat.; title: XVI. STRUCTURE-ACTIVITY RELATIONSHIPS AND MOLECULARMECHANISM OF ACTION OF 5,6- AND 5,7 -DHTXVII. NONSPECIFIC ACTIONS OF 5,6- AND 5,7-DHT; XVIII. FUNCTIONAL CONSEQUENCES OF CENTRALLY ADMINISTERED DlHYDROXYTRYPTAMINES; XIX. CHEMICAL LESIONING OF CENTRAL INDOLEAMINE PATHWAYS BY SUBSTANCES OTHER THAN 5,6- OR 5,7-DHT; XX. CONCLUSIONS; REFERENCES; Chapter 4. Determining Sensory Deficits in Animals; I. INTRODUCTION; II. THE NEUROLOGICAL EXAMINATION; III. CONDITIONING IN THE EXAMINATION OF SENSORY DEFICITS; IV. CORTICAL-EVOKED POTENTIAL TESTING FOR SENSORY DEFICIT; V. CONCLUSION; REFERENCES.