Coronavirus Replication and Reverse Genetics (Current Topics in Microbiology and Immunology)
Edition: 1 edition
Publisher: Springer
Published: November 23, 2004
Language: eng
Format: Hardcover
Number of pages: 257
ISBN-13: 9783540214946
Subjects: Virology; Microbiology; Science; Medical; Infectious Diseases; Life Sciences - Biology - Microbiology; Medical / Infectious Diseases
First sentence: Despite its unique property as the largest of the known plus-strand RNA genomes, the coronavirus genome shares with those of other plus-strand RNA viruses (excepting retroviruses) the properties of (1) infectiousness [and not using a packaged RNA-dependent RNA polymerase (RdRp)] (Brian et al. 1980; Schochetman et al. 1977) and (2) replication in the cytoplasm in close association with cellular membranes (Denison et al. 1999; Dennis and Brian 1982; Gosert et al. 2002; Sethna and Brian 1997; Shi et al. 1999; van der Meer et al. 1999).
Description: "This volume contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make reverse genetic studies possible, in order to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classic and recombinant vaccines to control coronavirus infections."--BOOK JACKET.