Drug repositioning
Subtitle: bringing new life to shelved assets and existing drugs
By: edited by Michael J. Barratt, Donald Frail
Publisher: John Wiley & Sons
Published: 2011
Place of publication: Hoboken
Language: eng
Number of pages: 477
ISBN-13: 9780470878279
Subjects: Pharmaceutical Preparations; Drug Industry; Methods; Computational Biology; Economics; Drug Repositioning
Notes: Includes bibliographical references and index.
Table of contents: title: Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison; title: Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald Frail and Michael Barratt; title: Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David Sequeira, and Maria Miller; title: Regulatory considerations and strategies for drug repositioning / Ken Phelps; title: Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb; title: Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.]; title: Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics and molecular modeling based approaches / Li Xie ... [et al.]; title: Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret Lee; title: Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael Saporito, Christopher Lipinski, and Andrew Reaume; title: Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam Morgan ... [et al.]; title: Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis Chong; title: Drug repositioning efforts by non-profit foundations; title: Business development strategies in the repositioning industry / Aris Persidis and Elizabeth Stark; title: A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.