The role of protein kinase C-epsilon (PKCepsilon) in ischemic preconditioning cardioprotection induced by enhancement of cell volume regulation.
Published: 2006
Language: eng
Number of pages: 137
ISBN-13: 9780494212486
Description: Enhancement of cell volume regulation is a key mechanism of cardioprotection induced by ischemic preconditioning. The specific role of PKC&egr; in modulating IPC protection against necrosis via an enhanced volume regulatory mechanism was addressed using a combined molecular and pharmacological approach in primary culture of adult rabbit cardiomyocytes. It was found that (1) PKC&egr; protects against ischemic cell death in a pathway that includes Cl - channel activity downstream, (2) PKC&egr; limits the extent of ischemic cardiomyocyte swelling with Cl- channel activity downstream of PKC&egr;, (C) PKC&egr; is involved in normal cell volume regulation in oxygenated cardiomyocytes, and Cl- activity is downstream of PKC&egr; in this response. The findings of this study support the hypothesis that the mechanism of PKC&egr; - mediated cardioprotection includes the activation of potent cell volume regulatory mechanisms, which delay ischemic cell swelling and cell death and involve the activation of volume regulated Cl- channels.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1382.

Thesis (M.Sc.)--University of Toronto, 2006.

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