Aggregation of therapeutic proteins
By: edited by Wei Wang, Christopher J. Roberts.
Contributors: Wang, Wei, 1957 Mar. 10-; Roberts, Christopher John, 1972-
Publisher: Wiley
Published: 2010
Place of publication: Hoboken, N.J
Language: eng
ISBN-13: 9780470411964
Subjects: Protein drugs; Aggregation (Chemistry); Recombinant Proteins -- therapeutic use; Cell Aggregation; Protein Conformation; Protein Folding; Recombinant Proteins -- metabolism
Description: "While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Aggregation of Therapeutic Proteins provides an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. This book also covers an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins. The knowledge in this book will help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area"--Provided by publisher.
Notes: Includes bibliographical references.
Table of contents: title: (Publisher-supplied data) Chapter 1. Fundamental Structures and Behaviors of Proteins /   Jennifer S. Laurence and C. Russell Middaugh; title: Chapter 2. Protein Aggregation Pathways, Kinetics, and Thermodynamics / Yi Li and Christopher J. Roberts; title: Chapter 3. Identification and Impact of aggregation Prone Regions in Proteins and Therapeutic Monoclonal Antibodies; title: Chapter 4. External Factors Affecting Protein Aggregation / Wei Wang, Ning Li, Stan Speaker; title: Chapter 5. Experimental Detection and Characterization of Protein Aggregates / Vikas K. Sharma and Devendra S. Kalonia; title: Chapter 6. Approaches to Control Protein Aggregation during Bulk Production / Linda O. Narhi, Yijia Jiang, Rohini Deshpande, Sohye Kang, and Joseph Shultz; title: Chapter 7. Protein Aggregation and Particle Formation: Effects of Formulation, Interfaces and Drug Product Manufacturing Operations / Hanns-Christian Mahler, Stefan Fischer, Theodore W. Randolph, and John F. Carpenter; title: Chapter 8. Approaches to Managing Protein Aggregation in Product Development / Wei Wang and Nicholas W. Warne; title: Chapter 9. Case Studies Involving Protein Aggregation / Rahul S. Rajan, Tiansheng Li, and Tsutomu Arakawa; title: Chapter 10. Aggregation and Immunogenicity of Therapeutic Proteins / Vasco Filipe, Andrea Hawe, Huub Schellekens, and Wim Jiskoot; title: Chapter 11. Regulatory Perspective on Aggregates as Product Quality Attribute / Wendy C. Weinberg, Linan Ha, Susan L. Kirshner, Daniela I. Verthelyi.