Physiologically based pharmacokinetic (PBPK) modeling and simulations
Subtitle: principles, methods, and applications in the pharmaceutical industry
By: Sheila Annie Peters
Publisher: Wiley
Published: 2011
Place of publication: Hoboken, N.J
Language: eng
Number of pages: 450
ISBN-13: 9780470484067
Subjects: Design; Pharmacokinetics; Drugs; Mathematical models; Biological Models; Drug Design
Description: The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceuticascience physiologicallyly-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void.
Notes: Includes bibliographical references and index.
Table of contents: title: Modelling in the pharmaceutical industry; title: Physiologically-based modelling; title: A review of pharmacokinetic principles; title: Physiological model for absorption; title: Physiological model for distribution; title: Physiological models for drug metabolism and excretion; title: Generic whole-body physiologically-based pharmacokinetic modelling; title: Variability, uncertainty and sensitivity analysis; title: Evaluation of drug-drug interaction risk with pbpk models; title: PBPK of biotherapeutics; title: Data integration and sensitivity analysis; title: Hypothesis generation and pharmacokinetic predictions; title: Integration of PBPK and pharmacodynamics; title: PBPK modelling of populations; title: PBPK models along the drug discovery and development value chain.