Drug efficacy, safety, and biologics discovery
Subtitle: emerging technologies and tools
By: [edited by] Sean Ekins, Jinghai J. Xu.
Contributors: Ekins, Sean.; Xu, Jinghai J.
Publisher: John Wiley & Sons
Published: 2009
Place of publication: Hoboken, N.J
Language: eng
Number of pages: 408
ISBN-13: 9780470225554
Subjects: Drug development -- Technological innovations; Pharmaceutical technology; Biological products; Drug Evaluation -- trends; Biological Products; Drug Design; Drug Toxicity; Technology, Pharmaceutical -- trends
Description: "This book offers readers an array of new emerging technologies. These technologies arm pharmaceutical scientists with more systematic and effective approaches for deciphering the complex interactions among chemstry, biology, and medicine, helping to ensure that more research efforts focus on drugs that can be successfully translated from the laboratory to the clinic and onto the market."--Jacket.
Notes: Includes bibliographical references and index.
Table of contents: title: Focus on fundamentals : towards better therapeutic index prediction / Jinghai J. Xu and Li J. Yu; title: High throughput protein-based technologies and computational models for drug development, efficacy, and toxicity / Leonidas G. Alexopoulos, Julio Saez Rodriguez, and Christopher W. Espelin; title: Cellular systems biology applied to pre-clinical safety testing : a case study of cellciphr cytotoxicity profiling / Lawrence Vernetti ... [et al.]; title: Systems pharmacology, biomarkers, and biomolecular networks / Aram Adourian ... [et al.]; title: Zebrafish models for human diseases and drug discovery / Hanbing Zhong, Ning-ai Liu, and Shuo Lin; title: Toxicity pathways and models : mining for potential side effects / Sean Ekins and Josef Scheiber; title: Computational systems biology modeling of dosimetry and cellular response pathways / Qiang Zhang ... [et al.]; title: Stem cell technology for embryotoxicity, cardiotoxicity, and hepatotoxicity evaluation / Julio C. Davila ... [et al.]; title: Telemetry technology for preclinical drug discovery and development / Yi Yang; title: Nanotechnology to improve drug delivery / Mayank D. Bhavsar, Shardool Jain, and Mansoor M. Amiji; title: Functional glycomics and the future of glycomic drugs / Ram Sasisekharan; title: Modeling efficacy and safety of engineered biologics / Jeff Chabot and Bruce Gomes; title: Regulation of gene expression by small, non-coding RNAS : practical applications / Roman Herrara and Eric Tien; title: Future perspectives of biological engineering in pharmaceutical research : the paradigm of modeling, mining, manipulation, and measurements / Jinghai J. Xu ... [et al.].