Prognostic significance of cardiac-specific troponins in patients hospitalized for congestive heart failure.
Published: 2005
Language: eng
Number of pages: 98
Description: Background. The prognostic significance of cardiac-specific troponins in acute heart failure is uncertain.Methods. This retrospective cohort study examined the association between cardiac troponin I and mortality in 2,025 patients newly hospitalized for heart failure in the province of Ontario, Canada.Conclusions. In patients hospitalized for heart failure, increased cardiac troponin I is a powerful and independent predictor of 30-day and 1-year mortality, and can permit early identification of patients with an increased risk of death.Results. Cardiac troponin I greater than 0.5 mug/ml occurred in 699 (34.5%) patients and was associated with higher mortality at 30 days (15.7% versus 6.9%; adjusted odds ratio 1.97; 95% confidence interval, 1.42-2.74; P &lt; 0.001) and 1 year (40.2% versus 26.1%; adjusted odds ratio 1.68; 95% confidence interval, 1.34-2.10; P &lt; 0.001). Increasing levels of cardiac troponin I were associated with progressive increases in 30-day and 1-year mortality (P &lt; 0.001 for trend).
Notes: Source: Masters Abstracts International, Volume: 44-02, page: 0815.

Thesis (M.Sc.)--University of Toronto, 2005.

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