The Biochemistry and Physiology of Peptidases
Contributors: Saghatelian, Alan; Kahne, Daniel; Gray, Nathanael
Published: 2013
Language: eng
Description: Peptidases regulate important physiological processes by controlling levels of bioactive peptides and occasionally through noncatalytic processes. This thesis presents a study of prolyl endopeptidase-like (PREPL), which is a peptidase involved in several human deletion syndromes, including hypotonia-cystinuria syndrome (HCS). Phenotypes tentatively attributed to PREPL deletion include hypotonia and decreased growth hormone (GH) levels. However, little is known about the mechanisms by which PREPL deletion causes these phenotypes.
Notes: Keywords: Calcitonin Gene Related Peptide, Hypotonia-Cystinuria Syndrome, Mass spectrometry, Peptidases, Peptide Profiling, Prolyl endopeptidase-like.

Thesis Ph.D. Harvard University 2013