Type 1 diabetes, macrophages and the genetics of the BBDP rat.
Published: 2004
Language: eng
Number of pages: 172
Description: The diabetes-prone BioBreeding (BBDP) rat develops type 1 diabetes (T1 D) spontaneously and is a model of human TID. The two known diabetes susceptibility loci of the BBDP rat, lyp and RT1u, were introgressed into a diabetes-resistant strain, ACI. The resulting double congenic ACI.1u.lyp animals were both diabetes- and insulitis-free, demonstrating the involvement of other susceptibility genes. To facilitate the mapping and identification of these genes, we sought to identify pre-diabetes, disease-related traits that could BBDP from ACI.1u.lyp strains. Phenotypic differences in macrophages, a lineage know to be involved in the pathogenesis of TID, were identified. Genome-wide linkage analysis of an F2 (ACI.1u.lyp x BBDP) intercross identified quantitative trait loci controlling the macrophage phenotypes on chromosomes 2, 4, 6, 7 and 8. However, these loci could not be linked to diabetes or insulitis due to the low incidence of disease in the F2 progeny. Insulitis was linked to chromosome 17.
Notes: Adviser:  Philippe Poussier.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 42-06, page: 2101.

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