Regulation of the proteolytic processing and function of Amyloid Precursor Protein by candidate ligands
Contributors: Selkoe, Dennis J.; Young-Pearse, Tracy L.; Wolfe, Michael; Stevens, Beth; Feany, Mel; Wolozin, Benjamin; Flanagan, John; Segal, Rosalind
Published: 2013
Language: eng
Description: Despite intense interest in the proteolysis of Amyloid Precursor Protein (APP) in Alzheimer's disease (AD), how the normal processing and function of this type I receptor-like glycoprotein is regulated remains ill-defined. APP is reported to function in neurodevelopment, including migration of neuronal precursor cells into the cortical plate. In recent years, several candidate ligands for APP, including F-spondin, Reelin, â1 Integrin, Contactins, and Lingo-1 have been reported. However, a cognate ligand for APP that regulates its function or processing has yet to be widely confirmed in multiple laboratories.
Notes: Keywords: Alzheimer's Disease, Amyloid Precursor Protein, cell migration, LINGO-1, Pancortin, Reelin.

Thesis Ph.D. Harvard University 2013