Novel technologies for high-throughput and high-content studies on zebrafish larvae
Contributors: Yanik, Mehmet F.; Howe, Robert D.; Zon, Leonard I.; Smith, Maurice A.
Published: 2013
Language: eng
Description: The zebrafish larva is an ideal candidate for in vivo high-throughput screening: it is a small vertebrate, it is optically transparent, possesses complex organs, and is easy to culture. In addition, genetic mutants and models of human diseases are widely available. Despite these attractive features there are no tools capable of screening at sufficient throughput and resolution to fully exploit the zebrafish. Here, I present a collection of technologies that enable high-throughput studies on zebrafish larvae at cellular resolution.
Notes: Keywords: high-content, high-throughput, phenotyping, screening, tomography, zebrafish.

Thesis Ph.D. Harvard University 2013