CIRCADIAN RHYTHM OF BLOOD PRESSURE IN SCHOOL-AGE CHILDREN OF NORMOTENSIVE AND HYPERTENSIVE PARENTS.
Contributors: University of Pennsylvania.
Published: 1989
Number of pages: 141
Subjects: Health Sciences, Nursing.; Biology, Animal Physiology.; Health Sciences, Medicine and Surgery.
Description: The purpose of this study was to describe the characteristics of the blood pressure rhythm in school-age children and to delineate the effect of parental history of hypertension on the circadian mesor and amplitude of blood pressure.

The sample consisted of 40 clinically healthy children aged 8 to 10 years. Twenty subjects had a parental history of hypertension and twenty did not. The children and their parents were recruited through nurses and other employees in two hospitals, parent-teacher associations in public and private schools, primary care physicians and cardiologists in the Greater Miami area.

Blood pressure was measured in the child's home every 2 hours during the day and every 90 minutes during the night for one 24-hour cycle using a Dinamap monitor (Model 1846 SX-P, Critikon) equipped with an automatic printer. Activity diaries were also used to record the child's physical activities and the times of sleeping, waking, and meals during the period of data collection.

Systolic and diastolic pressures were found to exhibit a circadian variation in some children, with maximum values during the day and minimum values during the night. Cosinor analyses of the data revealed statistically significant circadian rhythms for systolic pressure in 12 out of 40 subjects and for diastolic pressure in 12 out of 40 subjects. The acrophases for systolic and diastolic pressure occurred between 1200-1600 hours among children of normotensive parents and between 1200 to 1800 hours among children of hypertensive parents. The mean systolic mesor was 108.50 while the mean diastolic mesor was 61.41 for the entire sample. The mean amplitudes were 8.85 for systolic pressure and 7.44 for diastolic pressure.

T-test analyses demonstrated no statistically significant differences in the mean circadian mesors and amplitudes of blood pressure between children of normotensive parents and children of hypertensive parents. Significant positive correlations of moderate magnitude were found between diastolic mesor and age (r = 0.451, p = 0.003), between systolic mesor and height (r = 0.312, p = 0.050), between systolic mesor and weight (r = 0.551, p = 0.0002), and between diastolic mesor and weight (r = 0.384, p = 0.0143). A significant but negative correlation was also found between diastolic amplitude and age (r = $-$0.365, p = 0.021).

These findings have important implications for blood pressure measurement in children for purposes of screening, diagnosis, treatment, and research.
Notes: Source: Dissertation Abstracts International, Volume: 51-01, Section: B, page: 0144.

Thesis (PH.D.)--UNIVERSITY OF PENNSYLVANIA, 1989.

School code: 0175.