Characterization of impaired CD8+ T cell responses to Chlamydia trachomatis
Contributors: Starnbach, Michael N.; Lichtman, Andrew; Ingalls, Robin; Haining, Nicholas; Moody, Branch
Published: 2013
Language: eng
Description: Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. Irregular screening to identify infected individuals and a lack of sterilizing immunity to C. trachomatis has led to a dramatic increase in the number of reported C. trachomatis infections over the last twenty years. Repeated infections with C. trachomatis lead to serious sequelae such as pelvic inflammatory disease and ectopic pregnancy, which can result in infertility.
Notes: Keywords: CD8+ T cells, Chlamydia, Immunoinhibitory, PD-1, PD-L1.

Thesis Ph.D. Harvard University 2013