Myasthenia Gravis and Related Disorders
Edition: 1 edition
Publisher: Humana Press
Published: October 3, 2002
Language: eng
Format: Hardcover
Number of pages: 408
ISBN-13: 9781588290588
Subjects: Neurology & clinical neurophysiology; Neuromuscular diseases; Musculoskeletal Diseases; Medical / Nursing; physiopathology; Medical; Rheumatology; Neuroscience; Neurology - General; Medical / Neurology; Orthopedics; Myasthenia Gravis; Myoneural junction
First sentence: The aim of this chapter is to increase the reader's understanding of five factors: 1) the structure of the neuromuscular junction; 2) the mechanism triggering release of vesicles of acetylcholine from the nerve terminal; 3) the two ion channels on the postsynaptic membrane (Na+ channels and acetylcholine receptors) that are critical for converting the chemical signal from the nerve terminal into a propagated action potential on the muscle fiber; 4) the safety factor for neuromuscular transmission and characteristics of the neuromuscular junction that contribute to the safety factor; and 5) the mechanism by which disease compromises the safety factor, leading to neuromuscular transmission failure.
Notes: Current Clinical Neurology