Pharmaceutical Aspects of Oligonucleotides (Taylor & Francis Series in Pharmaceutical Sciences)
Contributors: Patrick Couvreur (Editor); Claude Malvy (Editor)
Publisher: CRC
Published: December 16, 1999
Language: eng
Format: Hardcover
Number of pages: 321
ISBN-13: 9780748408412
Subjects: Molecular biology; Drugs - Adverse Effects; Pharmaceutical Chemistry; Medical; Medical / Nursing; Pharmacology; Pharmacy; Medical / Pharmacology; Oligonucleotides; Therapeutic use; adverse effects
First sentence: As well as inhibiting gene expression through steric blockade of pre-mRNA splicing or initiation of translation, or through ribonuclease H-mediated ablation of mRNA, antisense oligonucleotides have been found to induce a variety of biological effects by mechanisms other than, or in addition to, those which might result from hybridization to the targeted mRNA.