Functional Genomics Approaches to Identify and Characterize Oncogenic Signaling
Contributors: Hahn, William C.; Weinberg, Robert A.; Janne, Pasi A.; Bass, Adam; Sabatini, David; Haigis, Kevin M.; Park, Peter J.
Published: 2013
Language: eng
Description: Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and survival. Suppression of the driving oncogene is highly effective for promoting tumor regression, a phenomenon termed "oncogenic addiction." By using unbiased genetic tools to functionally probe oncogenic addiction, we can identify cancer dependencies and characterize aspects of oncogenic signaling.
Notes: Keywords: ATARiS, HNF1B, RAS, RNAi, YAP.

Thesis Ph.D. Harvard University 2013