Natural history of hyperlipidemia in pediatric systemic lupus erythematosus (SLE).
Published: 2004
Language: eng
Number of pages: 230
Description: Purpose. To determine the etiology of hyperlipidemia in an inception cohort of 139 pediatric patients with SLE.Methods. The longitudinal lipid profile at diagnosis and 3 year follow-up, and 4 disease states (active, inactive, active by prednisone, active by SLEDAI) were determined. Patients on low dose (&le;12.5mg/day) and weaning dose (60-30-10mg/day) of prednisone were compared for association of corticosteroid dose and lipids. Lipid levels at various disease states were compared to distinguish the effects of disease activity from corticosteroids. The effects of individual disease manifestations on lipids were determined.Conclusion. Dyslipoproteinemia was common in pediatric SLE. Both disease and treatment related factors may contribute to this state.Results. Lipid abnormalities of high cholesterol (CHO), triglycerides (TRI), LDL-C, and low HDL-C were of the greatest magnitude and seen in the most number of patients at disease diagnosis. The magnitude of the lipid abnormality tended to decrease over time, but persisted throughout the follow-up period. When patients were on high doses of corticosteroids, elevated CHO and LDL-C persisted, but the HDL-C was in the normal range. TRI levels were higher in patients with active disease and were lower in those with inactive disease in the presence of high dose corticosteroids. However, CHO and TRI levels decreased correspondingly to prednisone dose. Overall disease activity had the predominant effect of increasing TRI while corticosteroids were associated with increased CHO and LDL-C. HDL-C levels were associated with both disease activity and corticosteroid use. Renal disease, and in particular proteinuria, was the disease manifestation which most significantly predicted lipids. Anti-malarial therapy was associated with lowering serum lipids only in the presence of active disease.
Notes: Adviser:  Earl Silverman.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0816.

MICR copy on microfiche (3 microfiches).