Applications of transition metal catalysis in drug discovery and development
Subtitle: an industrial perspective
By: edited by Matthew L. Crawley, Barry M. Trost
Publisher: John Wiley & Sons
Published: 2012
Place of publication: Hoboken, N.J
Language: eng
ISBN-13: 9780470631324
Subjects: Pharmaceutical Preparations; Drug Discovery; Chemistry; Catalysis; Transition Elements
Description: "This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development."--Provided by publisher.
Notes: Includes bibliographical references and index.
Table of contents: title: Transition metal catalysis in the pharmaceutical industry / Carl A. Busacca ... [et al.]; title: Selected applications of transition metal-catalyzed carbon-carbon cross-coupling reactions in the pharmaceutical industry / Hong C. Shen; title: Selected applications of Pd and Cu-catalyzed carbon-heteroatom cross-coupling reactions in the pharmaceutical industry / Jingjun Yin; title: Asymmetric cross-coupling reactions / William A. Szabo and Vince Yeh; title: Metathesis / Oliver Thiel; title: Transition metal-catalyzed synthesis of five and six membered heterocycles / Cheol K. Chung and Matthew L. Crawley; title: Oxidative catalysis / Lamont Terrell; title: Industrial asymmetric hydrogenation / Hans-Ulrich Blaser.