role of human subthalamic nucleus in saccade control.
Published: 2006
Language: eng
Number of pages: 217
ISBN-13: 9780494220269
Description: There is limited anatomical and physiological evidence to support a role for the subthalamic nucleus (STN) in saccade control. In this thesis, I investigated this role in greater detail at the single unit, population and motor performance levels by studying Parkinson's disease (PD) patients during and after deep brain stimulation (DBS) neurosurgery. Intraoperative microelectrode recordings from alert patients allowed testing of STN neurons for responses to saccades. Twenty percent of the STN neurons tested responded to saccades. Establishing that STN neurons receive saccade-related information was consistent with a role for STN in saccade control and provided the rationale for further investigations. Local field potentials (LFPs) reflect synchronous neuronal activity of populations of neurons or synchronous input to these neurons. A basal ganglia oscillatory model predicts that LFP oscillations in the beta range (11-30 Hz) should  decrease prior to limb movement onset. Changes in oscillatory power of both microelectrode and DBS-recorded STN LFPs near saccade onset were measured to determine if they were consistent with this model. However, increases in microelectrode LFP power in the beta range were more frequently observed than decreases. Decreases in STN LFP beta power occurred 1-2 s before saccade onset and increases in beta power occurred at saccade onset. The time course of these changes in STN DBS LFP oscillations are consistent with a role for STN in preparation, attention, motor or efferent copy functions. However, the high inter-patient variability in the oscillatory changes of DBS LFPs with saccades that was observed was not predicted by the oscillatory model. Finally, the effect of STN DBS on saccade performance was tested in PD patients. STN DBS improved saccade latency in externally-cued movements and saccade amplitude in internally-generated movements, suggesting that STN influences these parameters. In summary, these novel findings in human STN clearly implicate that STN is important in saccade control and have expanded our general knowledge of the motor function of STN.
Notes: Source: Dissertation Abstracts International, Volume: 68-01, Section: B, page: 0134.

Thesis (Ph.D.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.