Constitutive activity in receptors and other proteins
By: edited by P. Michael Conn
Contributors: ScienceDirect (Online service)
Series: Methods in enzymology -- 484, 485
Publisher: Elsevier/Academic
Published: 2010
Place of publication: Amsterdam; Boston, Mass
Language: eng
Format: [electronic resource] /
ISBN-13: 9780123812971; 9780123812995; 9780123812988; 9780123812964
Subjects: Biochemistry; SCIENCE; Life Sciences; Proteins; Cell receptors
Notes: Includes bibliographical references and indexes.

Description based on print version record.
Table of contents: title: v. 484. Constitutive activity at the cannabinoid CB(1) receptor and behavioral responses; title: Detecting constitutive activity and protean agonism at cannabinoid-2 receptor; title: Modulation of the constitutive activity of the ghrelin receptor by use of pharmacological tools and mutagenesis; title: Assessment of constitutive activity and internalization of GPR54 (KISS1-R); title: Assessment of constitutive activity in E-type prostanoid receptors; title: [Alpha](1D-adrenergic receptors constitutive activity and reduced expression at the plasma membrane; title: Constitutive activity of the histamine H(1) receptor; title: Constitutive activity of somatostatin receptor subtypes; title: Assessment of homologous internalization of constitutively active N111G mutant of AT(1) receptor; title: Methods to detect cell surface expression and constitutive activity of GPR6; title: [beta](3)-adrenoceptor agonists and (antagonists as) inverse agonists history, perspective, constitutive activity, and stereospecific binding; title: ^; title: Constitutive activity of the lutropin receptor and its allosteric modulation by receptor heterodimerization; title: Assessing constitutive activity of extracellular calcium-sensing receptors in vitro and in bone; title: Constitutive activity of neural melanocortin receptors; title: Measurement of constitutive activity of bmp type I receptors; title: Probing the constitutive activity among dopamine D1 and D5 receptors and their mutants; title: Identification of gain-of-function variants of the human prolactin receptor; title: Investigations of activated ACVR1/ALK2, a bone morphogenetic protein type i receptor, that causes fibrodysplasia ossificans progressiva; title: Identification and evaluation of constitutively active thyroid stimulating hormone receptor mutations; title: Assessment of constitutive activity of a G protein-coupled receptor, CPR2, in cryptococcus neoformans by heterologous and homologous methods; title: In vitro and in vivo assessment of mu opioid receptor constitutive activity; title: ^; title: ^^; title: Constitutively active [mu]-opioid receptors; title: Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: Strategies to identify CK2 substrates and manipulate its activity in mammalian cells; title: Assessment of CK2 constitutive activity in cancer cells; title: Structural basis of the constitutive activity of protein kinase CK2; title: Measuring the constitutive activation of C-jun N-terminal kinase isoforms; title: Measurement of constitutive mapk and PI3K/AKT signaling activity in human cancer cell lines; title: Constitutive activity of GPR40/FFA1 intrinsic or assay dependent?; title: Constitutive activity of trp channels methods for measuring the activity and its outcome; title: Measurement of orexin (hypocretin) and substance P effects on constitutively active inward rectifier K(+) channels in brain neurons; title: Characterization of G protein-coupled receptor kinase 4 and measuring its constitutive activity in vivo; title: ^; title: ^^; title: Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K, ACH) channels in the diseased heart; title: Assaying WAVE and WASH complex constitutive activities toward the Arp2/3 complex; title: Methods to assess the mechanism of protein function.; title: ^^; title: V.485. Identification and characterization of steroidogenic factor-1 inverse agonists; title: Assessment of inverse agonism for the angiotensin II type 1 receptor; title: Measurement of inverse agonism in [beta]-adrenoceptors; title: Techniques for studying inverse agonist activity of antidepressants at recombinant nonedited 5-HT(C-INI) receptor and native neuronal 5-HT(2C) receptors; title: Differential inverse agonism at the human muscarinic M3 receptor; title: Ghrelin receptor: High constitutive activity and methods for developing inverse agonists; title: Constitutive activity and inverse agonism at the [alpha](A) and [alpha](B) adrenergic receptor subtypes; title: Measurement of inverse agonism of the cannabinoid receptors; title: Constitutively active thyrotropin and thyrotropin-releasing hormone receptors and their inverse agonists; title: Inverse agonists and antagonists of retinoid receptors; title: [gamma]-aminobutyric acid type A (GABA(A)) receptor subtype inverse agonists as therapeutic agents in cognition; title: ^; title: Assays for inverse agonists in the visual system; title: Receptor-driven identification of novel human a adenosine receptor antagonists as potential therapeutic agents; title: Inverse agonist activity of steroidogenic factor SF-1; title: Methods to measure G-protein-coupled receptor activity for the identification of inverse agonists; title: Use of pharmacoperones to reveal GPCR structural changes associated with constitutive activation and trafficking; title: Application of large-scale transient transfection to cell-based functional assays for ion channels and GPCRs; title: Quantification of RNA editing of the serotonin 2C receptor (5-HT(C)R) ex vivo; title: Strategies for isolating constitutively active and dominant-negative pheromone receptor mutants in yeast; title: Development of a GPR23 cell-based [beta]-lactamase reporter assay; title: Computational modeling of constitutively active mutants of GPCRs C5A receptor; title: TSH receptor monoclonal antibodies with agonist, antagonist, and inverse agonist activities; title: ^; title: ^^; title: Current standards, variations, and pitfalls for the determination of constitutive TSHR activity in vitro; title: Toward the rational design of constitutively active KCA3.1 mutant channels; title: Fusion proteins as model systems for the analysis of constitutive GPCR activity; title: Screening for novel constitutively active CXCR2 mutants and their cellular effects; title: A method for parallel solid-phase synthesis of iodinated analogs of the cannabinoid receptor type I (CB) inverse agonist rimonabant; title: Coexpression systems as models for the analysis of constitutive GPCR activity; title: Modeling and simulation of inverse agonism dynamics; title: Design and use of constitutively active STAT5 constructs; title: In vitro and in vivo assays of protein kinase CK2 activity.; title: ^^