Bioinspired, dynamic, structured surfaces for biofilm prevention
Contributors: Aizenberg, Joanna; Spaepen, Frans; Weitz, David; Auguste, Debra
Published: 2012
Language: eng
Description: Bacteria primarily exist in robust, surface-associated communities known as biofilms, ubiquitous in both natural and anthropogenic environments. Mature biofilms resist a wide range of biocidal treatments and pose persistent pathogenic threats. Treatment of adherent biofilm is difficult, costly, and, in medical systems such as catheters, frequently impossible. Adding to the challenge, we have discovered that biofilm can be both impenetrable to vapors and extremely nonwetting, repelling even low surface tension commercial antimicrobials. Our study shows multiple contributing factors, including biochemical components and multiscale reentrant topography.
Notes: Keywords: Adhesion, Bacteria, Biofilm, Fabrication, Nanostructure, Surface engineering.

Thesis Ph.D. Harvard University 2012