Regulatory Interaction of the Class III PI3 Kinase Complex and p53
Contributors: Yuan, Junying; Thomas, Sheila M.; Frank, David A.; Wei, Wenyi; Baehrecke, Eric H.
Published: 2012
Language: eng
Description: Autophagy is a catabolic pathway utilized by cells to maintain homeostasis. Dysregulation of this pathway often leads to various diseases, such as cancers and neurodegeneration. Therefore, autophagy must be tightly regulated by the extracellular environment or signaling pathways. The class III PI3 kinase complex, a lipid kinase complex functioning in converting phosphatidylinositol to phosphatidylinositol-3-phosphate, is a key regulator of autophagy that functions as a signaling hub where multiple regulatory signals converge.
Notes: Keywords: Autophagy, Beclin 1, p53, Vps34.

Thesis Ph.D. Harvard University 2012