Protein tyrosine phosphatase control of metabolism
By: Kendra K. Bence, editor
Publisher: Springer
Published: 2013
Place of publication: New York
Language: eng
Number of pages: 273
ISBN-13: 9781461478546
Subjects: Protein-tyrosine phosphatase; Metabolism; Regulation; Protein Tyrosine Phosphatases; Metabolic Diseases; Enzymology; Physiology; Protein-Tyrosine Kinases
Description: Tyrosine phosphorylation is a rapid and reversible protein modification catalyzed by the yin and yang activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). A multitude of PTPs have been implicated in human disease, with a growing number of PTPs now known to play major roles in prevalent metabolic diseases including obesity and type 2 diabetes. Recent studies into PTP function in the context of metabolism highlight the importance of understanding the specific substrates and binding partners of these enzymes, the regulation of PTP activity, and the cell/tissue specificity of PTP functions. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism.--
Notes: Includes bibliographical reference and index.
Table of contents: title: Redox Regulation of PTPs in Metabolism: Focus on Assays  -- Yang Xu, Benjamin G. Neel; title: Quantitative Modeling Approaches for Understanding the Role of Phosphatases in Cell Signaling Regulation: Applications in Metabolism  -- Matthew J. Lazzara; title: Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism  -- Yannan Xi, Fawaz G. Haj; title: PTP1B and TCPTP in CNS Signaling and Energy Balance  -- Kendra K. Bence; title: PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress  -- Mirela Delibegovic, Nimesh Mody; title: Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling  -- Águeda González-Rodríguez; title: PTP1B in Obesity-Related Cardiovascular Function  -- Pimonrat Ketsawatsomkron; title: Role of the SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism  -- Maria I. Kontaridis; title: Metabolic Effects of Neural and Pancreatic Shp2  -- Zhao He, Sharon S. Zhang; title: Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism  -- Ari Elson; title: The Role of LMPTP in the Metabolic Syndrome  -- Stephanie M. Stanford; title: Mitogen-Activated Protein Kinase Phosphatases in Metabolism  -- Ahmed Lawan, Anton M. Bennett; title: Glycogen Metabolism and Lafora Disease -- Peter J. Roach.