Immunology of gene therapy
By: [edited by] Roland Herzog.
Contributors: Herzog, Roland, Ph. D.
Publisher: John Wiley & Sons
Published: 2008
Place of publication: Hoboken, N.J
Language: eng
Number of pages: 397
ISBN-13: 9780470134061
Subjects: Gene therapy; Immunology; Gene Therapy; Gene Transfer Techniques; Immune Tolerance; Immunity, Natural; Transplantation Immunology
Description: Summarizes and presents a broad review of the latest immunological advances in the field of genetic therapy. The book's unique organization, which approaches the topic from a vector and target organ point of view, rather than from a disease-specific perspective, reflects the ways in which gene therapies are being investigated today. This provides scientists and physicians attempting to develop gene therapies with a powerful tool for comparing vectors and target organs side by side, making the right investigative and clinical choices, anticipating potential problems, modifying protocols, and obtaining a broader view of the issues. Each chapter covers local and systemic responses; strengths and characteristics of innate responses; strengths and characteristics of adaptive (i.e., T helper, cytotoxic T lymphocyte, and B cell/antibody) responses to the vector and to transgene products; and preexisting immunity in humans.
Notes: Includes bibliographical references.
Table of contents: title: The immunology of gene transfer : an overview / David Lillicrap; title: Innate immune responses to nucleic acids / Ishii Akira; title: The anti-viral innate immune response / Daniel Muruve; title: Immune responses to adenoviral vectors / Dmitry M. Shayakhmetov; title: Immune responses to lentiviral vectors / Lung-Ji Chang; title: Immune responses to adeno-associated virus vectors / Hildegund Ertl; title: Immunology after in utero and neonatal gene transfer / Simon Waddington; title: Immunology of hepatic gene transfer / Roland Herzog; title: Immune responses to adenoviral, AAV, and lentiviral vector used for gene therapy of brain diseases / Pedro Lowenstein; title: Immunology of cutaneous gene transfer / Soosan Ghazizadeh; title: Immune responses to pulmonary gene therapy / Terence Flotte; title: Induction of immune tolerance through gene transfer to hematopoietic stem cells / John Iacomini; title: Reconstitution of the immune system by gene therapy / Adrian Thasher; title: Genetics of the immune response to proteins expressed after gene transfer / Jay Lozier; title: Immune modulation and transient suppression strategies / Valder Arruda; title: Gene therapy for autoimmune diseases / Nicholas Giannoukakis; title: Engineering of viral capsids to evade the host immune system / Hildegard Büning.