Introduction to Statistical Methods for Clinical Trials (Texts in Statistical Science)
Edition: 1 edition
Publisher: Chapman & Hall/CRC
Published: November 19, 2007
Language: eng
Format: Hardcover
Number of pages: 464
ISBN-13: 9781584880271
Subjects: Pharmacology; Medical; Mathematics; Science/Mathematics; Mathematics / Statistics; Probability & Statistics - General; Research
Description: This book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals.