Dose finding by the continual reassessment method
By: Ying Kuen Cheung
Series: Chapman & Hall/CRC biostatistics series; Chapman & Hall/CRC biostatistics series -- 41.
Publisher: Taylor & Francis
Published: 2011
Place of publication: Boca Raton
Language: eng
ISBN-13: 9781420091519
Subjects: Clinical trials; Biostatistics; Dose-response relationship; Drugs; Methods; Phase I as Topic Clinical Trials; Dose-Response Relationship, Drug; Maximum Tolerated Dose
Notes: Includes bibliographical references and index.
Table of contents: title: Dose finding in clinical trials; title: The continual reassessment method; title: One-parameter dose toxicity models; title: Theoretical properties; title: Empirical properties; title: Specifications of a CRM design; title: Initial guesses of toxicity probabilities; title: Least informative normal prior; title: Initial design; title: The time-to-event CRM; title: CRM with multiparameter models; title: When the CRM fails; title: Stochastic approximation.