Tumor dormancy, quiescence, and senescence
Subtitle: Aging, cancer, and noncancer pathologies
By: edited by M.A. Hayat
Series: Tumor dormancy and cellular quiescence and senescence -- volume 2; Tumor dormancy and cellular quiescence and senescence -- v. 2.
Publisher: Springer
Published: 2014
Place of publication: Dordrecht
Language: eng
Number of pages: 320
ISBN-13: 9789400777262; 9789400777255
Copyright date: 2014
Subjects: Clinical Medicine; Internal Medicine; HEALTH & FITNESS; Cellular Senescence; Physiopathology; Tumors; Neoplasms; Disease Progression; General; Physiology; Neoplasm Metastasis; Evidence-Based Medicine; MEDICAL; Diseases
Other titles: Aging, cancer, and noncancer pathologies
Description: "In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases suchas breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M.A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor"--Publisher's description.
Notes: Includes bibliographical references and index.
Table of contents: title: Molecular Mechanisms --; title: Asymmetric Dimethylarginine Accelerates Cellular Senescence  -- Fotunato Scalera and Stefanie M. Bode-Böger; title: Membrane-Derived Extracellular Vesicles from Endothelial Progenitor Cells Activate Angiogenesis  -- Vincenzo Cantaluppi, Federico Figliolini, Maria Chiara Deregibus and Giovanni Camussi; title: Induction of P21-Dependent Senescence: Role of NAE Inhibitor MLN4924  -- Yongfu Pan, Yi Sun and Lijun Jia; title: Regulation of the Novel Senescence Pathway by SKP2 E3 Ligase  -- Guocan Wang, Yuan Gao, Li Chen, Ying-Jan Wang and Hui-Kuan Lin; title: Oncogene-Induced Senescence: Role of Mitochondrial Dysfunction  -- Olga Moiseeva and Gerardo Ferbeyre; title: Interleukin-6 Induces Premature Senescence Involving Signal Transducer and Activator of Transcription 3 and Insulin-Like Growth Factor-Binding Protein 5  -- Hirotada Kojima, Hiroyuki Kunimoto, Toshiaki Inoue and Koichi Nakajima; title: A Role for the Nuclear Lamina Shape in Cell Senescence and Aging  -- Christiaan H. Righolt and Vered Raz; title: Upregulation of Alpha-2-Macroglobulin in Replicative Senescence  -- Li Wei Ma, Guo Dong Li and Tan Jun Tong; title: Elevation of Ceramide in Senescence: Role of Sphingolipid Metabolism  -- Mark E. Venable; title: Molecular Signals Underlying Hair Follicle Morphogenesis and Cutaneous Regeneration  -- Xusheng Wang and Yaojiong Wu; title: Role of Chromatin-Remodeling Factor Jun Dimerization Protein 2 (JDP2) in Cellular Senescence  -- Kazunari K. Yokoyama and Kung-Kai Kuo; title: Induction of Cellular Senescence: Role of Mitogen-Activated Protein Kinase-Interacting Kinase 1  -- Samira Ziaei and Naoko Shimada; title: Mechanisms of Premature Cell Senescence  -- Julien Maizel, Jun Chen and Michael S. Goligorsky; title: Tumor and Cancer --; title: Nuclear Protein Pirin Negates the Cellular Senescence Barrier Against Cancer Development  -- Silvia Licciulli and Myriam Alcalay; title: Defects in Chromatin Structure and Diseases  -- Umberto Galderisi and Gianfranco Peluso; title: The Role of Fibrosis in Tumor Progression and the Dormant to Proliferative Switch  -- Lara H. El Touny, Dalit Barkan and Jeffrey E. Green; title: Diagnosis of Branchial Cyst Carcinoma: Role of Stem Cells and Dormancy  -- Athanassios Kyrgidis; title: Function of the ING Proteins in Cancer and Senescence  -- Uyen M. Tran, Uma Rajarajacholan and Karl Riabowol; title: Premalignancy and Cellular Senescence  -- Hussein A. Abbas and Raya Saab; title: Loss of Cdh1 Triggers Premature Senescence in Part via Activation of Both the RB/E2F1 and the CLASPIN/CHK1/P53 Tumor Suppressor Pathways  -- Shavali Shaik, Pengda Liu, Zhiwei Wang and Wenyi Wei; title: Suppression of Premature Senescence and Promotion of Metastatic Transformation: Role of Reduced TGF-Beta Signaling in Human Cancer Progression  -- Shu Lin and Lu-Zhe Sun; title: Senescence Escape in Melanoma: Role of Spleen Tyrosine Kinase SYK  -- Marcel Deckert and Sophie Tartare-Deckert; title: Micrometastatic Cancer Cells: Role of Tumor Dormancy in Non-small Cell Lung Cancer (NSCLC)  -- Stefan Werner, Michaela Wrage and Harriet Wikman; title: Quiescent CD4 + T Cells Inhibit Multiple Stages of HIV Infection  -- Jerome A. Zack and Dimitrios N. Vatakis; title: Stem Cells and Cancer Stem Cells --; title: Senescent-Derived Pluripotent Stem Cells Are Able to Redifferentiate into Fully Rejuvenated Cells  -- Ollivier Milhavet and Jean-Marc Lemaitre; title: The Transcription Factor GATA2 Regulates Quiescence in Haematopoietic Stem and Progenitor Cells  -- Neil P. Rodrigues and Alex J. Tipping; title: Dormancy and Recurrence of Cancer Stem Cells in Bone: Role of Bone Morphogenetic Proteins  -- Sambad Sharma, Fei Xing and Kounosuke Watabe; title: Role of Microenvironment in Regulating Stem Cell and Tumor Initiating Cancer Cell Behavior and Its Potential Therapeutic Implications -- Ana Krtolica.