Characterization of lung tumor-propagating cells reveals a role for CD24 and Yap/Taz in lung cancer progression and metastasis
Contributors: Kim, Carla; Hock, Hanno; McAllister, Sandra; Hahn, William; Varelas, Bob (Xaralabos)
Published: 2014
Language: eng
Description: Lung cancer is the leading cause of cancer deaths worldwide. A large part of this high mortality rate is due to the onset of metastatic disease prior to diagnosis. Advances in treatment for metastatic disease may be achieved by understanding more about the identity of metastatic tumor cells and the mechanisms those cells employ to spread throughout the body. This thesis examined the relationship between cells capable of tumor propagation upon serial transplantation (tumor-propagating cells, or TPCs) and those with metastatic potential.
Notes: Keywords: CD24, lung cancer, metastasis, Taz, tumor propagating cells, Yap.

Thesis Ph.D. Harvard University 2014