Sensing Inorganic Phosphate Starvation by the Phosphate-Responsive (PHO) Signaling Pathway of Saccharomyces cerevisiae
Contributors: O'Shea, Erin K.; Murray, Andrew; Denic, Vlad
Published: 2013
Language: eng
Description: Inorganic phosphate (Pi) is an essential nutrient whose intracellular levels are maintained by the PHO pathway in Saccharomyces cerevisiae. Pi limitation triggers upregulation of the PHO genes whose gene products primarily function to counterbalance the Pi deficiency. Despite a growing catalogue of genes that are involved in signaling of the PHO pathway, little is known about how cells actually sense Pi limitation.
Notes: Keywords: genetic screen, inorganic phosphate, metabolic profiling, metabolism.

Thesis Ph.D. Harvard University 2013