Tropomyosin
By: edited by Peter Gunning.
Contributors: Gunning, Peter, 1950-
Series: Advances in experimental medicine and biology -- v. 644
Publisher: Springer Science+Business Media; Landes Bioscience
Published: 2008
Place of publication: New York, N.Y; Austin, Tex
Language: eng
ISBN-13: 9780387857657
Subjects: Tropomyosins; Tropomyosin
Description: A recent review of one of my grant applications commented on the 'rediscovery of tropomyosin'. I was tempted to write back in my rebuttal to the reviewer that I didn't realise it had been lost. Uncharacteristic maturity prevailed and I resisted the temptation, but I was struck by the underlying observation that research on the structure and function of tropomyosin has been somewhat invisible, particularly in terms of the cytoskeleton isoforms. So, how can it be that one of the two major components of the actin filament has been so thoroughly overlooked? I suspect that the answer is disappointingly pedestrian. Whereas the biochemistry of the 1980s revealed the potential of tropomyosin isoforms to diversify the function of actin filaments, the subsequent disenchantment with isoform biology in general in the 1990s inhibited growth of this field. With the development of more sophisticated experimental approaches we are now seeing a growing realisation of the importance of tropomy.
Notes: Includes bibliographical references and index.
Table of contents: title: Introduction and historical perspective / Peter Gunning; title: Structure and evolution of tropomyosin genes / Bernadette Vrhovski, Nadine Thézé, and Pierre Thiébaud; title: Tropomyosin exons as models for alternative splicing / Clare Gooding and Christopher W.J. Smith; title: Tropomyosin gene expression in vivo and in vitro / Galina Schevzov and Geraldine O'Neill; title: Tropomyosin : function follows structure / Sarah E. Hitchcock-DeGregori; title: Dimerization of tropomyosins / Mario Gimona; title: Cooperative binding of tropomyosin to actin / Larry S. Tobacman; title: Tropomyosin and the steric mechanism of muscle regulation / William Lehman and Roger Craig; title: Role of tropomyosin in the regulation of contraction in smooth muscle / Steve Marston and M. El-Mezgueldi; title: Tropomyosin as a regulator of cancer cell transformation / David M. Helfman ... [et al.]; title: The role of tropomyosin in heart disease / David F. Wieczorek, Ganapathy Jagatheesan, and Sudarsan Rajan; title: Tropomyosins in skeletal muscle diseases / Anthony J. Kee and Edna C. Hardeman; title: Tropomyosins in human diseases : ulcerative colitis / Kiron M. Das and Manisha Bajpai; title: Tropomyosin function in yeast / David Pruyne; title: Isoform sorting of tropomyosins / Claire Martin and Peter Gunning; title: Human tropomyosin isoforms in the regulation of cytoskeleton functions / Jim Jung ... [et al.]; title: Tropomyosins regulate the impact of actin binding proteins on actin filaments / Uno Lindberg ... [et al.]; title: Tropomyosin and ADF/cofilin as collaborators and competitors / Thomas B. Kuhn and James R. Bamburg; title: Caldesmon and the regulation of cytoskeletal functions / C.L. Albert Wang; title: Tropomyosins as discriminators of myosin function / E. Michael Ostap; title: Tropomodulin/tropomyosin interactions regulate actin pointed end dynamics / Alla S. Kostyukova; title: Emerging issues for tropomyosin structure, regulation, function, and pathology / Peter Gunning.