Breast cancer chemosensitivity
By: edited by Dihua Yu, Mien-Chie Hung.
Contributors: Yu, Dihua.; Hung, Mien-chie.
Series: Advances in experimental medicine and biology -- v. 608
Publisher: Springer Science+Business Media; Landes Bioscience
Published: 2007
Place of publication: New York; Austin, Tex
Language: eng
Number of pages: 175
ISBN-13: 9780387740379
Subjects: Breast -- Cancer -- Chemotherapy; Drug resistance in cancer cells; Breast Neoplasms -- drug therapy; Antineoplastic Agents -- pharmacology; Drug Resistance, Neoplasm -- physiology
Description: A group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. An example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.
Notes: Includes bibliographical references and index.
Table of contents: title: Overview of resistance to systemic therapy in patients with breast cancer / Ana Maria Gonzalez-Angulo, Flavia Morales-Vasquez and Gabriel N. Hortobagyi; title: Roles of multidrug resistance genes in breast cancer chemoresistance / M. Tien Kuo; title: Therapy-induced apoptosis in primary tumors / David J. McConkey; title: Cell cycle deregulation in breast cancer: insurmountable chemoresistance or achilles' heel? / Laura Lambert and Khandan Keyomarsi; title: p53, BRCA1 and breast cancer chemoresistance / Kimberly A. Scata and Wafik S. El-Deiry; title: Integrin-mediated adhesion: tipping the balance between chemosensitivity and chemoresistance / Mary M. Zutter; title: Insulin-like growth factors and breast cancer therapy / Xianke Zeng and Douglas Yee; title: EGF receptor in breast cancer chemoresistance / Robert B. Dickson and T.B. Deb; title: Molecular mechanisms of ErbB2-mediated breast cancer chemoresistance / Ming Tan and Dihua Yu; title: Estrogen receptors in resistance to hormone therapy / Matthew H. Herynk and Suzanne A.W. Fuqua; title: Novel approaches for chemosensitization of breast cancer cells: the E1A story / Yong Liao, Dihua Yu and Mien-Chie Hung.