Effect of the mood stabilizer valproate on intracellular calcium homeostatis in bipolar I disorder.
Published: 2004
Language: eng
Number of pages: 144
Description: Elevated basal ([Ca2+]B) and lysophosphatidic acid (LPA) receptor-stimulated intracellular calcium (Ca2+) concentrations ([Ca2+]S) in B lymphoblast cell lines (BLCLs) from bipolar I disorder (BD) patients compared with healthy subjects, and the modulation of these parameters by chronic exposure to lithium  ex vivo, implicate abnormal intracellular Ca2+ dynamics in BD. The objective of this study was to discern whether chronic treatment with the mood stabilizer, valproic acid (VPA) exerts similar effects to a therapeutic concentration of lithium on store-operated Ca2+ entry (SOCE) and/or receptor-operated Ca2+ influx mechanisms. Chronic, but not acute, treatment of BLCLs, from BD and healthy patients, with a therapeutically relevant concentration of VPA, significantly attenuated thapsigargin-stimulated, but not LPA-induced, Ca2+ responses. These observations suggest that the mood stabilizer action of VPA may also involve modification of intracellular Ca2+ dynamics at the level of the SOCE, possibly by affecting the homeostatic control of ER Ca 2+.
Notes: Advisers:  Jerry J. Warsh; Peter P. Li.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0832.

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