Predictive approaches in drug discovery and development
Subtitle: biomarkers and in vitro/in vivo correlations
By: edited by J. Andrew Williams ... [et al.].
Series: Wiley series on technologies for the pharmaceutical industry; Wiley series on technologies for the pharmaceutical industry
Publisher: Wiley
Published: 2011
Place of publication: Hoboken, N.J
Language: eng
Number of pages: 387
ISBN-13: 9780470170830
Subjects: Drug Discovery; Pharmacological Biomarkers; Pharmaceutical Technology; Preclinical Drug Evaluation
Notes: Includes bibliographical references and index.
Table of contents: title: The importance of biomarkers in translational medicine / Joseph Fleishaker; title: Fit for purpose validation of biochemical assays : challenges and solutions / Gabriella Szekely-Klepser and Scott Fountain; title: Transcriptional profiling in biomarker discovery / Michael E. Burczynski ... [et al.]; title: Proteomic biomarker approaches in drug discovery and development / Ruth A. Vanbogelen, Jeffrey D. Thomas, and Diane Alessi; title: Application of metabolomics to pharmaceutical research and development / Qiuwei Xu and William H. Schaefer; title: Vascular biomarkers and imaging studies / Karin Potthoff, Ulrike Fiedler, and Joachim Drevs; title: Cardiovascular biomarkers as examples of success and failure in predicting safety in humans / Simon Authier ... [et al.]; title: Use of molecular imaging for receptor occupancy decision making in drug development / R. Paul Maguire; title: Biosensors for clinical biomarkers / Sara Tombelli and Marco Mascini; title: US regulatory perspective on biomarker development / Rajnikath Madabushi, Lawrence Lesko, and Janet Woodcock; title: EU regulatory perspective on biomarkers / Ian Hudson; title: Use of biomarkers in drug development : Japanese perspectives / Yoshiaki Uyama ... [et al.]; title: In vitro-in vivo correlations of hepatic drug clearance / R. Scott Obach; title: The potential of in silico and in vitro approaches to predict in vivo drug-drug interactions and ADMET/TOX properties / Kenneth Bachmann and Sean Ekins; title: In vitro-in vivo correlations in drug discovery and development : concepts and applications in toxicology / Rex Denton, Kimberly Brannen, and Buce D. Car; title: Assessing the potential for induction of cytochrome P450 enzymes and predicting the in vivo response / Jiunn H. Lin.