The effects of incision size on craniofacial nociceptive neuronal excitability.
Published: 2006
Language: eng
Number of pages: 120
ISBN-13: 9780494210949
Description: The aim of this study was to determine if incision size influences craniofacial nociceptive neuronal activation (magnitude [BAR] and duration [BAR-dur]) and the development of neuroplastic changes (mechanical activation threshold [MAT], mechanoreceptive field [RF], and spontaneous activity [SA]). Neuronal activity was recorded from trigeminal subnucleus caudalis (Vc)/C1 neurons in 32 halothane-anaesthetized rats. The effects a 30-, 22-, or 14-gauge incision or lidocaine infiltration prior to a 14-gauge incision were evaluated. Incision size significantly influenced BAR-dur (2-way ANOVA, Tukey test, P&lt;0.05) but not BAR (P>0.05) nor the development of neuroplastic changes (Chi-squared tests, P>0.05). Lidocaine pretreatment significantly reduced BAR (2-way ANOVA, Tukey test, P&lt;0.05) and BAR-dur (2-way ANOVA, Tukey test, P&lt;0.05), but did not consistently prevent neuroplastic changes (Fisher Exact tests, P>0.05). These findings suggest that a reduced incision size or the use of local anaesthesia may reduce pain experienced during needle insertion or conservative surgical incision within the craniofacial region.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1440.

Thesis (M.Sc.)--University of Toronto, 2006.

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