Advances in Amino Acid Mimetics and Peptidomimetics
Publisher: Elsevier
Published: 1999
Place of publication: Burlington
Language: eng
Format: [electronic resource]
Number of pages: 315
ISBN-13: 9780080552637
Description: Peptidomimetics have found wide application as bioavailable, and often potent mimetics of natural peptides. They form the basis of important classes of enzyme inhibitors, they act as receptor agonists and antagonists, and they have even been used to mimic DNA structure. Recent advances in the use of solid-phase organic synthesis have paved the way for the preparation of libraries of these structures to allow the rapid optimization of theri biological properties and hence therapeutic potential. We are also beginning to gain a greater understanding of the structural features of this class of com.
Notes: Description based on print version record.
Table of contents: title: Front Cover; ADVANCES IN AMINO ACID MIMETICS AND PEPTIDOMIMETICS; Copyright Page; CONTENTS; LIST OF CONTRIBUTORS; PREFACE; CHAPTER 1. COMBINATORIAL SYNTHESIS OF PEPTIDOMIMETICS; CHAPTER 2. THE DEVELOPMENT OF NOVEL NONCOVALENT THROMBIN INHIBITORS; CHAPTER 3. PEPTIDOMIMETICS DESIGNED FOR ORAL ABSORPTION; CHAPTER 4. RARE PROTEIN TURNS:?-TURN, HELIX-TURN-HELIX, AND cis-PROLINE MIMICS; CHAPTER 5. DESIGN OF NON-PEPTIDE AGONISTS AND ANTAGONISTS FOR NEUROPEPTIDE RECEPTORS; CHAPTER 6. AMINO ACID MIMETICS AND DESIGN OF PEPTIDOMIMETICS FOR OPIOID AND MELANOCORTIN RECEPTORS: GENERAL PERSPECTIVES.