Epigenetic regulation of hematopoiesis in zebrafish
Contributors: Zon, Leonard; Cantor, Alan; Camargo, Fernando; Churchman, Stirling; Speck, Nancy
Published: 2012
Language: eng
Description: The initiation of the hematopoietic program is orchestrated by key transcription factors that recruit chromatin regulators in order to activate or inhibit blood target gene expression. To generate a complete compendium of chromatin factors that establish the genetic code during developmental hematopoiesis, we conducted a large-scale reverse genetic screen targeting 425 chromatin factors in zebrafish and identified over 30 novel chromatin regulators that function at distinct steps of embryonic hematopoiesis.
Notes: Keywords: chd7, chromatin factor, hematopoiesis, jmjd2b, unk, zebrafish.

Thesis Ph.D. Harvard University 2012