Functional interactions of tumor suppressors Brca1 and Mus81.
Published: 2007
Language: eng
Number of pages: 87
ISBN-13: 9780494273548
Description: Genomic instability is a prominent feature of malignantly transformed cancer cells. Tumor suppressor genes play an important role in maintaining the genomic integrity of the cell. BRCA1 is a known tumor suppressor and individuals with mutations in this gene have a heightened risk of breast cancer. This work investigates the functional interactions between Brca1 and tumor suppressor gene Mus81, hypothesized to cooperate in the repair of stalled replication forks. Preliminary findings presented in this study suggest a physical interaction exists between Mus81 and Brca1. To investigate the in vivo functional interplay between Brca1 and Mus81, a T cell conditional mouse model was created.  Mus81 deletion did not exacerbate the T cell development defect seen in Brca1 deficient T cell conditional mice. This study is important as it attempts to contribute to current concepts of DNA damage repair pathways functioning within mammalian cells and provides valuable results to guide future research.
Notes: Source: Masters Abstracts International, Volume: 45-06, page: 3140.

Thesis (M.Sc.)--University of Toronto, 2007.

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