Adverse drug reactions
By: Jack Uetrecht, editor
Series: Handbook of experimental pharmacology -- 196; Handbook of experimental pharmacology -- v. 196.
Publisher: Springer
Published: 2010
Place of publication: Heidelberg; London; New York
Language: eng
Number of pages: 556
ISBN-13: 9783642006623; 9783642006630
Subjects: Pharmaceutical Preparations; Drug Toxicity; Side effects; Drugs; Adverse effects; Arzneimittelnebenwirkung
Notes: Includes bibliographical references and index.
Table of contents: title: Pt. 1. Target organ toxicity.; title: Drug-induced liver injury / Michael Holt, Cynthia Ju.; title: Drug herpersensitivity reactions involving skin / Oliver Hausmann, Benno Schnyder, Werner J. Pichler.; title: Adverse drug reactions affecting blood cells / Richard H. Aster.; title: Molecular mechanisms of adverse drug reactions in cardiac tissue / Reza Tabrizchi.; title: Mechanisms of drug-induced nephrotoxicity / Thomas D. Nolin, Jonathan Himmelfarb.; title: Receptor- and reactive intermediate-mediated mechanisms of teratogenesis / Peter G. Wells, Crystal J.J. Lee, Gordon P. McCallum, Julia Perstin, Patricia A. Harper.; title: Pt. II. Mediators/Biochemical pathways.; title: Role of reactive metabolites in drug-induced hepatotoxicity / A.M. Srivastava, J. L. Maggs, D. J. Antoine, D. P. Williams, D. A. Smith, B. K. Park.; title: Role of cytokines in the mechanism of adverse drug reactions / Mary Jane Masson, Lindsay A. Collins, Lance R. Poh.; title: Keap1-Nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity / Ian M. Copple, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park.; title: Signal transduction pathways involved in drug-induced liver injury / Derick Han, Mie Shinohara, Maria D. Ybanez, Behnam Saberi, Neil Kaplowitz.; title: Mictrochondrial involvement in drug-induced liver injury / Dominique Pessayre, Abdellah Mansouri, Alain Berson, Bernard Fromenty.; title: Pt. III. Examples/Models.; title: Mechanisms of acetaminophen-induced liver necrosis / Jack A. Hinson, Dean W. Roberts, Laura P. James.; title: Drug-induced liver injury in humans: the case of Ximelagtran / M. Keisu, T.B. Andersson.; title: Troglitazone / Tsuyoshi Yokoi.; title: Neviropine hypersensitivity / M. Popovic, J.M. Shenton, J. Chen, A. Baban, T. Tharmanathan, B. Mannargudi, D. Abdulla, J.P. Uetrecht.; title: Mechanisms of adverse drug reactions to biologics / Janet B. Clarke.; title: Pt. IV. Risk factors/Screening drug candidates.; title: Pharmacogenetics of idiosyncratic adverse drug reactions / Munir Pirmohamed.; title: Danger hypothesis applied to idiosyncratic drug reactions / Jinze Li, Jack P. Uetrecht.; title: Approaches for minimizing metabolic activation of new drug candidates in drug discovery / Sanjeev Kumar, Kaushik Mitra, Kelem Kassahun, Thomas A. Baillie.