Chemical and cellular defenses against foreign pathogens
Contributors: Walz, Thomas; Walsh, Christopher T.; Saghatelian, Alan
Published: 2012
Language: eng
Description: Bacterial and viral infections affect billions of people each year. While bacterial infections are treated by the use of antibiotics, viral infections are eradicated by the immune system. This thesis comprises two parts. Part I presents the reconstitution of enzymes required for the synthesis of the minimal pharmacophore of moenomycin A (MmA), a molecule with antibacterial activity.
Notes: Keywords: Antibiotics, Electron, MDA5, Microscopy, Moenomycin, RIG-I.

Thesis Ph.D. Harvard University 2012