Improved mono-synaptic tracing tools for mapping, monitoring
By: Thomas Robert Reardon
Publisher: [publisher not identified]
Published: 2016
Place of publication: [New York, N.Y.?]
Language: eng
Description: This work concerns the use of engineered genetic tools to build maps of the mammalian nervous system. Within the practice of circuit neuroscience, one of the most effective tools to emerge in recent years are the neurotropic viruses. Among these are modified strains of rabies virus which are made safe for laboratory use. We introduce here a novel form of engineered rabies virus with substantially improved utility for exploring the structure and function of neural circuits. Additionally, using this new tool, an investigation of an important motor circuit, the cortico-striatal circuit, is presented.
Notes: Department: Neurobiology and Behavior.

Thesis advisor: Thomas M. Jessell.

Thesis (Ph.D.)--Columbia University, 2016.