Hot-melt extrusion
Subtitle: pharmaceutical applications
By: edited by Dionysios Douroumis
Publisher: Wiley
Published: 2012
Place of publication: Hoboken
Language: eng
ISBN-13: 9780470711187
Subjects: Drug delivery systems; SCIENCE / Chemistry / Organic; Extrusion; Molding (Chemical technology); Drugs; Pharmaceutical chemistry
Description: "Hot-melt extrusion (HME)  - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets.Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include:  principles and die design of single screw extrusion  twin screw extrusion techniques and practices in the laboratory and on production scale  HME developments for the pharmaceutical industry  solubility parameters for prediction of drug/polymer miscibility in HME formulations  the influence of plasticizers in HME  applications of polymethacrylate polymers in HME  HME of ethylcellulose, hypromellose, and polyethylene oxide  bioadhesion properties of polymeric films produced by HME  taste masking using HME  clinical studies, bioavailability and pharmacokinetics of HME products  injection moulding and HME processing for pharmaceutical materials  laminar dispersive & distributive mixing with dissolution and applications to HME  technological considerations related to scale-up of HME processes  devices and implant systems by HME  an FDA perspective on HME product and process understanding  improved process understanding and control of an HME process with near-infrared spectroscopy  Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science"--

"First book related to the use of hot melt extrusion for pharmaceutical applications"--
Notes: Includes bibliographical references and index.