Dissecting Protein-protein Interactions that Regulate the Spindle Checkpoint in Budding Yeast
Contributors: Murray, Andrew W.; Losick, Richard; Schier, Alexander; Denic, Vlad
Published: 2012
Language: eng
Description: Errors in segregation of genetic materials are detrimental to all organisms. The budding yeast ensures accurate chromosome segregation by employing a system called the spindle checkpoint. The spindle checkpoint, which consists of proteins such as Mad1, Mad2, Mad3, Bub1, and Bub3, monitors the attachment of microtubules to the chromosomes and prevents cell cycle progression until all chromosomes are properly attached.
Notes: Keywords: Budding Yeast, Spindle Checkpoint.

Thesis Ph.D. Harvard University 2012