implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly.
Published: 2006
Language: eng
Number of pages: 97
ISBN-13: 9780494213094
Description: Persistently elevated GH and IGF-I levels are associated with increased mortality in patients with acromegaly. Their response to somatostatin analogs (SSA), however, is variable. This study sought to examine the significance of somatotroph adenoma type on response to SSA. Forty patients treated postoperatively with the SSA octreotide were evaluated and assessed for normalization of IGF-I levels and GH responses. Multivariate analysis confirmed that a densely granulated adenoma was the strongest predictor of complete response [adjusted odds ratio (OR), 58.41, 95% confidence interval (CI), 1.24--1000.00; P = 0.04] compared with other covariates, including older age at time of diagnosis (OR, 1.15/yr; 95% CI, 1.01--1.31; P = 0.03), and tumor stage of 3 or less (OR, 29.77; 95% CI, 1.01--885.45, P &lt; 0.05). In conclusion, somatotroph tumor type represents a strong clinical predictor of response to SSA treatment and will help to identify patients who warrant more vigilant management of their disease.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1493.

Thesis (M.Sc.)--University of Toronto, 2006.

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