Skin graft vascularization with poly methacrylic acid-co-methyl methacrylate beads
Subtitle: an in vivo model of angiogenesis.
Published: 2004
Language: eng
Number of pages: 139
Description: The objective of this study was to investigate the effect of poly methacrylic acid-co-methyl methacrylate beads (MAA beads) on angiogenesis and wound healing. Autologous and artificial skin grafts were used to close rodent and porcine full thickness excisional wounds. Previous work revealed enhanced angiogenesis with MAA beads implanted into a rodent peritoneum. However, determining the functional significance of these blood vessels, particularly in the context of wound healing, has not been done. In this study, MAA beads were topically applied to the wound beds prior to graft placement. MAA beads enhanced skin graft vascularization when compared to grafts treated without beads or with negative control beads. Grafts treated with MAA beads had improved survival compared to controls; a demonstration of enhanced functional angiogenesis. These results support the strategy of using implanted biomaterials as therapeutic angiogenic agents. MAA beads may have a role in augmenting vascularization in wound healing.
Notes: Advisers:  Joel Fish; Michael Sefton.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0902.

MICR copy on microfiche (2 microfiches).