DNA replication and human disease
By: edited by Melvin L. DePamphilis.
Contributors: DePamphilis, Melvin L.
Series: Cold Spring Harbor monograph series -- 46
Publisher: Cold Spring Harbor Laboratory Press
Published: 2006
Place of publication: Cold Spring Harbor, N.Y
Language: eng
Number of pages: 814
ISBN-13: 9780879697662
Subjects: DNA -- Synthesis; Medical genetics
Description: At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed.
Notes: Includes bibliographical references and index.