Semi-parametric models for cost-effectiveness analysis
Subtitle: improving the efficiency of estimation from censored data
Published: 2006
Language: eng
Number of pages: 112
ISBN-13: 9780494159149
Description: In a cost-effectiveness analysis of clinical trial data, interest centres on the differences in mean cost and mean effectiveness between two treatment groups. One way of estimating these differences is through semi-parametric models that express a patient's expected cost and expected effectiveness as linear functions of baseline covariates, including treatment groups. Clinical trial data are often subject to right censoring, and this must be accounted for appropriately in order to obtain consistent estimates of the regression coefficients. Although this can be achieved through inverse-probability weighting, the resulting estimators may not be efficient. This thesis uses existing results on semi-parametric efficiency to suggest new "improved" estimators for the regression coefficients. When cost histories are available, estimation of mean cost becomes a multivariate estimation problem, since costs are typically auto-correlated within a patient. By specifying the semi-parametric model as a multivariate regression, this auto-correlation can be used to further improve efficiency. Two further extensions to the model are considered. The first pools information across time intervals by allowing the regression coefficients for mean cost to be the same for each interval. A test for this assumption of equality is developed. The second extension allows time-dependent covariates to be included in the model. Both inverse-probability and improved estimators for these extended models are derived. The improved estimators are evaluated through two simulation studies to demonstrate that they do improve upon the efficiency of the inverse-probability estimators. The roles of the censoring fraction, the sample size, the multivariate approach and pooling on the relative efficiency of the estimators are explored, and the adequacy of the theoretical variance estimators is evaluated. The methods are then applied to three datasets. The first two datasets are clinical trials and are used to illustrate the benefits of the improved estimators in practice. Although both the models and the simulation studies use mean survival time as the measure of effectiveness, the second dataset shows how the results can be extended to mean quality-adjusted survival time. The third dataset contains longitudinal observational data on LDL-cholesterol levels and patient costs, and calls for a regression model with a time-dependent covariate.
Notes: Thesis (Ph.D.)--University of Toronto, 2006.

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