The process of new drug discovery and development
By: edited by Charles G. Smith, James T. O'Donnell.
Contributors: Smith, Charles G.; O'Donnell, James, Pharm. D.
Edition: 2nd ed.
Publisher: Informa Healthcare; CRC Press
Published: 2006
Place of publication: New York
Language: eng
Number of pages: 668
Subjects: Drugs -- Research -- History.; Drugs -- Design -- History.; Drug Design.; Drug Evaluation, Preclinical.; Drug Evaluation.; Médicaments -- Recherche -- Histoire.; Médicaments -- Conception -- Histoire.
Notes: Rev. ed. of: The process of new drug discovery and development / Charles G. Smith. c1992.

Includes bibliographical references and index.
Table of contents: title: Overview of the current process of new drug discovery and development / Charles G. Smith and James T. O'Donnell; title: Integrated drug product development: from lead candidate selection to life-cycle management / Madhu Pudipeddi, Abu T.M. Serajuddin, and Daniel Mufson; title: The impact of combinatorial chemistry on drug discovery / Michael H. Rabinowitz and Nigel Shankley; title: High-throughput screening: enabling and influencing the process of drug discovery / Carol Ann Homon and Richard M. Nelson; title: Pharmacological and pharmaceutical profiling: new trends / Joanne Bowes ... [et al.]; title: Cell-based analysis of drug response using moving optical gradient fields / Jeff M. Hall ... [et al.].; title: Patient-derived primary cells in high-throughput differential antitumor screens: let the patients be the guide / Irwin A. Braude; title: The evolving role of the caco-2 cell model to estimate intestinal absorption potential and elucidate transport mechanisms / Jibin Li and Ismael J. Hidalgo; title: The promise of metabonomics in drug discovery / Harold J. Kwalwasser and Pauline Gee; title: Pharmacogenetics and pharmacogenomics in drug development and regulatory decision-making: report of the first FDA-PWG-PhRMA-druSafe workshop / Lawrence J. Lesko ... [et al.]; title: Drugs from molecular targets for CNS and neurodegenerative diseases / William T. Comer and Gönül Veliçelebi; title: Safety pharmacology / Jean-Pierre Valentin and Tim G. Hammond; title: Nonclinical drug safety assessment / Frederick E. Reno; title: Preclinical genotoxicity testing: past, present and future / Richard H.C. San; title: The need for animals in biomedical research / Charles G. Smith; title: Defining the actual research approach to the new drug substance / Charles G. Smith; title: Pharmacokinetics: pharmacodynamics in new drug development / Sarfaraz K. Niazi; title: Pharmaceutics and compounding issues in new drug development and marketing / Loyd V. Allen; title: Late stage and process development activities / Charles G. Smith; title: Contract research organizations: role and function in new drug development / F. Richard Nichol; title: The front lines of clinical research: the industry / Lori Nesbitt; title: Horizons for cancer chemotherapy (and nonchemotherapy) / Daniel D. Von Hoff; title: Human immunodeficiency virus/acquired immune deficiency syndrome: clinical testing challenges / Vincent Idemyor; title: Common technical document: the changing face of the new drug application / Justina A. Molzon; title: Electronic publishing / Heather L. Wallace; title: The important role of pharmacists in a complex risk-management system: managing the risks from medical product use by focusing on patient education, monitoring, and adverse event reporting / Justina A. Molzon; title: Liability, litigation, and lessons in new drug development / James T. O'Donnell; title: Problems in the nondrug marketplace / Stephen Barrett; title: Patents and new product development in the pharmaceutical and biotechnology industries / Henry Grabowski; title: The pharmaceutical revolution: drug discovery and development / John C. Somberg; title: The discovery of Rituxan / Mitchell E. Reff; title: Funding the birth of a drug: lessons from the sell side / Howard E. Greene; title: Innovations for the drug development pathway: what is needed now / Janet Woodcock; title: Managing R & D uncertainty and maximizing the commercial potential of pharmaceutical compounds using the dynamic modeling framework / Mark Paich ... [et al.].