Sequence alignment
Subtitle: methods, models, concepts, and strategies
By: edited by Michael S. Rosenberg.
Contributors: Rosenberg, Michael S., 1972-
Publisher: University of California Press
Published: 2009
Place of publication: Berkeley
Language: eng
Number of pages: 337
ISBN-13: 9780520256972
Subjects: Bioinformatics; Computational biology; Sequence Alignment -- methods
Description: "The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences - making sure that sequences from one source are properly compared to those from other sources - remains a complicated but underappreciated aspects of comparative molecular biology. This volume is about the practice of alignment, the procedures by which alignments are established, and, more importantly, how the outcomes of any alignment algorithm should be interpreted."--BOOK JACKET.
Notes: Includes bibliographical references and index.
Table of contents: title: Sequence alignment : concepts and history; title: Insertion and deletion events, their molecular mechanisms, and their impact on sequence alignments; title: Local versus global alignments; title: Computing multiple sequence alignment with template based methods; title: Sequence evolution models for simultaneous alignment and phylogeny reconstruction; title: Phylogenetic hypotheses and the utility of multiple sequence alignment; title: Structural and evolutionary considerations for multiple sequence alignment of RNA, and the challenges for algorithms that ignore them; title: Constructing alignment benchmarks; title: Simulation approaches to evaluating alignment error and methods for comparing alternate alignments; title: Robust inferences from ambiguous alignments; title: Strategies for efficient exploitation of the informational content of protein multiple alignments.