Gene-drug interactions and the evolution of antibiotic resistance
Contributors: Kishony, Roy; Mitchison, Timothy J.; Springer, Michael; Gore, Jeff; Hung, Deborah T.
Published: 2013
Language: eng
Description: The evolution of antibiotic resistance is shaped by interactions between genes, the chemical environment, and an antibiotic's mechanism of action. This thesis explores these interactions with experiments, theory, and analysis, seeking a mechanistic understanding of how different interactions between genes and drugs can enhance or constrain the evolution of antibiotic resistance.
Notes: Keywords: antibiotics, drug resistance, evolution, gene regulation, genetic interactions, mutations.

Thesis Ph.D. Harvard University 2013