randomized controlled trial of liposomal lidocaine versus placebo for intravenous cannulation of children in the emergency department.
Published: 2005
Language: eng
Number of pages: 108
Description: Objectives. To compare the effectiveness, success rate of cannulation and rate of adverse events for liposomal lidocaine versus placebo during IV cannulation.Introduction. This study investigated the analgesic efficacy of liposomal lidocaine 4% cream versus placebo for IV cannulation of children 1 month to 17 years old presenting to the Emergency Department.Methods. 142 children receiving an IV were randomized to liposomal lidocaine cream or placebo. The graduate student, parent, and child (5 to 17 years old) rated pain before and immediately following the first IV insertion attempt using the Faces Pain Scale - Revised (FPS-R).Conclusion. Liposomal lidocaine reduced pain, improved cannulation success rate, and was not associated with clinically significant adverse events.Results. Patients who received liposomal lidocaine had lower pain scores (p = 0.01 for child FPS-R, p &lt; 0.001 for parent/graduate student FPS-R) and a higher cannulation success rate at first attempt (p = 0.018). Both groups had similar rates of skin reactions.
Notes: Thesis (M.Sc.)--University of Toronto, 2005.

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Source: Masters Abstracts International, Volume: 44-01, page: 0327.

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