Cutaneous wound healing with methacrylic acid-co-methyl methacrylate beads.
Published: 2006
Language: eng
Number of pages: 116
ISBN-13: 9780494213209
Description: Methacrylic acid-co-methyl methacrylate (MAA) beads have been shown to induce angiogenesis. The mechanism underlying this response remains unclear. The purpose of this thesis was to develop a wound healing model for evaluation of the mechanism(s) whereby MAA beads induce angiogenesis and to evaluate the impact of MAA beads on the wound healing response. Mice were utilized to test two different models, artificial skin grafting and diabetic wound healing. In the first model, MAA beads seeded into the collagen matrix of artificial skin did not improve graft vascularization. In the second model, topical application of MAA beads to wounds created in diabetic mice stimulated angiogenesis and promoted wound closure. MAA beads did not affect the number of macrophages within the wound however the angiogenic effect may involve a change in phenotype. Wound tissue was further analyzed by flow cytometry to quantify individual sub-populations of cells and permit subsequent analyses using gene microarrays.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1453.

Thesis (M.Sc.)--University of Toronto, 2006.

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