Conserved genetic modules controlling lateral organ development
Subtitle: Polycomb Repressive Complex 2 and ASYMMETRIC LEAVES1 homologs in the lower eudicot Aquilegia
Contributors: Kramer, Elena M.; Schier, Alex; Bomblies, Kirsten; Extavour, Cassandra
Published: 2013
Language: eng
Description: Development in multicellular organisms relies on establishing and maintaining gene expression profiles that give cells identity. Transcription factors establish gene expression profiles by integrating positional, temporal, and environmental cues to regulate genes essential for a cell's identity. These signals are often short lived while the differentiated state may persist for a long time. Epigenetic factors maintain these gene expression profiles by making heritable chemical alterations to target gene chromatin to stabilize transcriptional patterns. Here we explore the evolution and function of an epigenetic regulator, the Polycomb Repressive Complex 2 (PRC2), and a transcription factor, ASYMMETRIC LEAVES 1 (AS1) , in the lower eudicot Aquilegia.
Notes: Keywords: Aquilegia, ASYMMETRIC LEAVES 1, Complex Leaves, Evolution, Lateral Organ Development, Polycomb Repressive Complex 2.

Thesis Ph.D. Harvard University 2013