Current trends in monoclonal antibody development and manufacturing
By: edited by Steven J. Shire ... [et al.].
Contributors: American Association of Pharmaceutical Scientists
Series: Biotechnology: pharmaceutical aspects -- v. 11; Biotechnology: pharmaceutical aspects -- v. 11.
Publisher: Springer; AAPS Press
Published: 2010
Place of publication: New York
Language: eng
Number of pages: 351
ISBN-13: 9780387766423; 9780387766430
Subjects: Biosynthesis; Biotechnology; Pharmacokinetics; Methods; Monoclonal Antibodies; Monoclonal antibodies; Analysis
Notes: Includes bibliographical references and index.
Table of contents: title: 1. Introduction / Wayne R. Gombotz and Steven J. Shire; title: pt. I. Design of therapeutic MABS. 2. CDR repair: a novel approach to antibody humanization / Mark S. Dennis; title: 3. Nanobodies, single-domain antigen-binding fragments of camelid heavy-chain antibodies / Gholamreza Hassanzadeh Ghassabeh, Serge Muyldermans, and Dirk Saerens; title: pt. II. Expression and production of MABS. 4. GPEx® a flexible method for the rapid generation of stable, high expressing, antibody producing mammalian cells lines / Gregory T. Bleck; title: 5. Advancing our cell culture platform: incorporating lessons learned and new technologies / Carole Heath; title: pt. III. Recovery and purification. 6. Addressing changes associated with technology transfer: a case study / Michele M. Myers ... [et al.]; title: 7. Concepts for disposables in biopharmaceutical manufacture / Joachim K. Walter and Uwe Gottschalk; title: pt. IV. Formulation and delivery. 8. Formulation and delivery issues for monoclonal antibody therapeutics / Ann L. Daugherty and Randall J. Mrsny; title: 9. Challenges in the development of high protein concentration formulations / Steven J. Shire, Zahra Shahrock, and Jun Liu.; title: 10. Protein immobilization by crystallization and precipitation: an alternative to lyophilization / Karoline Bechtold-Peters; title: pt. V. Analytics and specification setting for MABS. 11. Characterizing high affinity antigen/antibody complexes by kinetic and equilibrium based methods / Andrew W. Drake, David G. Myszka, and Scott L. Klakamp; title: 12. Analytical characterization of monoclonal antibodies: linking structure to function / Reed J. Harris ... [et al.]; title: 13. Analysis of irreversible aggregation, reversible self-association and fragmentation of monoclonal antibodies by analytical ultracentrifugation / James D. Andya, Jun Liu, and Steven J. Shires; title: 14. Biophysical signatures of monoconal antibodies / N. Harn ... [et al.]; title: pt. VI. Pharmacokinetics and immunogenicity. 15. Impact of Fc glycosylation on monoclonal antibody effector functions and degradation by proteases / T. Shantha Raju; title: 16. Immunogenicity assessment of antibody therapeutics / P. stas, Y. Gansemans, and I. Lasters; title: pt. VII. Armed antibodies and new classes of antibodies. 17. Production of monoclonal antibodies in E. coli / Dorothea E. Reilly and Daniel G. Yansura; title: 18. Recent advances in the use of antibody drug conjugates for cancer theapy / Peter D. Senter; title: 19. Antibody radiolabeling / Corinne Bensimon and Russell Redshaw.