Mitochondria and their role in cardiovascular disease
By: by José Marín-García, Director, The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA,  ; with contributions by Alexander Akhmedov, Senior Research Scientist, The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA, and Vitalyi Rybin, Gordon W. Moe, Professor, Department of Medicine, University of Toronto, St. Michael Hospital, Toronto, Canada
Contributors: Akhmedov, Alexander, author; Rybin, Vitalyi, author; Moe, Gordon W., author
Publisher: Springer
Published: 2013
Place of publication: New York
Language: eng
Number of pages: 500
ISBN-13: 9781461445982; 9781461445999
Subjects: Cardiovascular system; Diseases; Mitochondrial pathology; Cardiovascular Diseases; Etiology; Physiopathology; Heart Mitochondria; Metabolism; Myocardium
Description: "Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology."--
Notes: Includes bibliographical references and index.
Table of contents: title: Section I: General Principles of Mitochondria and the Heart. Introduction to Mitochondria in the Heart ; Methods to Study Mitochondrial Structure and Function ; Mitochondrial Structure, Composition, and Dynamics ; Mitochondrial Biogenesis ; Mechanisms of Bioenergy Production in Mitochondria ; Bioenergetics Interplay Between Cardiac Mitochondria and Other Subcellular Compartments.; title: Section II: Heart Mitochondria Signal Transduction: Stem Cells. Endothelial Mitochondria: Contribution to Cardiovascular Function and Disease ; Heart Mitochondria: Receivers and Transmitters of Signals ; Stem Cells and Mitochondria.; title: Section III: Stress and Cell Death. Heart Mitochondrial ROS and Oxidative Stress ; Cell-Death Pathways and Mitochondria.; title: Section IV: Mitochondria in Pediatric Cardiology. Mitochondria in Pediatric Cardiovascular Diseases.; title: Section V: The Aging Heart and Mitochondria. Mitochondria in the Aging Heart.; title: Section VI: Mitochondria in Atherosclerosis, Hypertension and Ischemia. The Role of Mitochondria in Atherosclerosis ; The Role of Mitochondria in Hypertension ; Role of Mitochondria in Ischemia and Cardioprotection.; title: Section VII: Mitochondria in Heart Failure and Dysrhythmias. Mitochondrial Dynamics in Health and Disease ; Mitochondria Play an Essential Role in Heart Failure ; Mitochondria and Cardiac Dysrhythmias.; title: Section VIII: Mitochondria in Heart Metabolism. Diabetes and Cardiac Mitochondria ; The Role of Mitochondria in the Metabolic Syndrome and Insulin Resistance ; Thyroid Hormone and Myocardial Mitochondria.; title: Section IX: Mitochondrial Therapy. Targeting the Mitochondria in Cardiovascular Diseases.; title: Section X: Looking to the Future of Mitochondria and the Heart. Current Progress and Future Perspectives: Toward Mitochondrial Medicine.