Evaluation of drug candidates for preclinical development
Subtitle: pharmacokinetics, metabolism, pharmaceutics, and toxicology
By: [edited by] Chao Han, Charles B. Davis, Binghe Wang.
Contributors: Han, Chao.; Davis, Charles B.; Wang, Binghe, PhD.
Publisher: John Wiley & Sons
Published: 2010
Place of publication: Hoboken, N.J
Language: eng
ISBN-13: 9780470044919
Subjects: Drug development; Pharmacokinetics; Drugs -- Metabolism; Drug Evaluation, Preclinical; Drug Discovery; Drug Industry -- standards; Pharmaceutical Preparations -- metabolism; Pharmacology -- methods
Notes: Includes index.
Table of contents: title: Pharmacokinetics in preclinical drug development : an overview / Dion Brocks; title: The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You; title: Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke; title: The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan; title: Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani; title: Prediction of the pharmacokinetics in humans / Chao Han and Remash Bambal; title: Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki; title: Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, Bruce D. Car; title: Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown.