Cardiac restoration with a biodegradable cardiac patch.
Published: 2007
Language: eng
Number of pages: 190
ISBN-13: 9780494273746
Description: Conclusions. An acellular cardiac patch can integrate with the heart by cell engraftment, collagen deposition and angiogenesis. BMC infusion may increase angiogenesis in the patch.Objective. We evaluated the feasibility of using an acellular patch to repair the left ventricular (LV) apex.Methods. Rats underwent LV apical resection and replacement with gelatin mesh. At 2 days, 1, 2, 4, 8 and 16 weeks, LV function, cell infiltration, neovascularization, matrix formation and biomaterial degradation were evaluated. Enhancement of patch remodeling was also investigated by intravenous bone marrow cell infusion.Results. The acellular patch repaired the LV apex. Biomaterial resorbed over time and was replaced by infiltrated cells and collagen. Blood vessels were observed in the newly formed tissue, which was enhanced by cell infusion.
Notes: Source: Masters Abstracts International, Volume: 45-06, page: 3124.

Thesis (M.Sc.)--University of Toronto, 2007.

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